DABRAFENIB MESYLATE

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Search structure


Trade Names	TAFINLAR
Synonyms	Dabrafenib mesilate Dabrafenib mesylate GSK-2118436 METHANESULFONATE SALT GSK-2118436B GSK-2118436B MESYLATE GSK-2118436B METHANESULFONATE SALT GSK2118436B GSK2118436B, METHANE SULFONATE SALT METHANE SULFONATE SALT Tafinlar
Status
Molecule Category	Salt-form
UNII	B6DC89I63E
EPA CompTox	DTXSID70152500
Parent Compound:	DABRAFENIB

Structure


InChI Key	YKGMKSIHIVVYKY-UHFFFAOYSA-N
Smiles	CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1.CS(=O)(=O)O
InChI	InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H24F3N5O5S3
Molecular Weight	615.68
AlogP	5.36
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	110.86
Molecular species	NEUTRAL
Aromatic Rings	4.0
Heavy Atoms	35.0

Pharmacology

Mechanism of Action	Action	Reference
Serine/threonine-protein kinase B-raf inhibitor	INHIBITOR	DailyMed

Target Conservation


Protein: Serine/threonine-protein kinase B-raf Description: Serine/threonine-protein kinase B-raf Organism : Homo sapiens P15056 ENSG00000157764

Cross References

Resources	Reference
ChEBI	75048
ChEMBL	CHEMBL2105729
FDA SRS	B6DC89I63E
KEGG	D10064
PubChem	44516822
SureChEMBL	SCHEMBL1127269
ZINC	ZINC68153186

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025