CRISABOROLE

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC D11AH06
UNII Q2R47HGR7P
EPA CompTox DTXSID10238231

Structure

InChI Key USZAGAREISWJDP-UHFFFAOYSA-N
Smiles N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1
InChI
InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H10BNO3
Molecular Weight 251.05

Pharmacology

Mechanism of Action Action Reference
Phosphodiesterase 4 inhibitor INHIBITOR PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 670 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4A
- 55-490 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B
- 55-490 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4C
- 55-490 - - -
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D
- 55-490 - - -
Enzyme Phosphodiesterase Phosphodiesterase 7 Phosphodiesterase 7A
- 730 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 55-830 - - -
Klebsiella pneumoniae
- 670 - - -
Mus musculus
- - - - 43.55-78

Target Conservation

Protein: Phosphodiesterase 4
Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Organism : Homo sapiens
P27815 ENSG00000065989
Protein: Phosphodiesterase 4
Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Organism : Homo sapiens
Q07343 ENSG00000184588
Protein: Phosphodiesterase 4
Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Organism : Homo sapiens
Q08493 ENSG00000105650
Protein: Phosphodiesterase 4
Description: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Organism : Homo sapiens
Q08499 ENSG00000113448

Cross References

Resources Reference
ChEBI 134677
ChEMBL CHEMBL484785
DrugBank DB05219
DrugCentral 5201
FDA SRS Q2R47HGR7P
Guide to Pharmacology 9151
PubChem 44591583
SureChEMBL SCHEMBL595261
ZINC ZINC000169748244
CONTENTS