CLARITHROMYCIN


Trade Names	BIAXIN BIAXIN XL CLARITHROMYCIN
Synonyms	6-o-methylerythromycin A-56268 ABBOTT-56268 Biaxin Biaxin Xl Pac Biaxin xl Clarie xl Clarithromycin Clarithromycin Extended Release Clarithromycin identity Clarosip Cyllind Erythromycin, 6-o-methyl- Febzin xl Klacid
Status
Molecule Category	Free-form
ATC	J01FA09
UNII	H1250JIK0A
EPA CompTox	DTXSID3022829


InChI Key	AGOYDEPGAOXOCK-KCBOHYOISA-N
Smiles	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(OC)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI	InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

Property Name	Value
Molecular Formula	C38H69NO13
Molecular Weight	747.96
AlogP	2.44
Hydrogen Bond Acceptor	14.0
Hydrogen Bond Donor	4.0
Number of Rotational Bond	8.0
Polar Surface Area	182.91
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	52.0

Mechanism of Action	Action	Reference
Bacterial 70S ribosome inhibitor	INHIBITOR	PubMed PubMed DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor	-	-	0.64	-	18-45
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	5.1-80.47

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	56.72-80.47
Helicobacter pylori	-	-	-	-	81.9
Homo sapiens	-	-	-	-	5.1-73.1
Mycobacterium avium	-	-	-	-	95-95
Rattus norvegicus	-	-	0.64	-	-
Streptococcus pneumoniae	-	90	-	-	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Countries
Croatia
Czech Republic
Germany
Hungary
India
Romania
Serbia
Slovakia
Slovenia
South Africa
Sweden
Vietnam

Resources	Reference
ChEBI	3732
ChEMBL	CHEMBL1741
DrugBank	DB01211
DrugCentral	668
FDA SRS	H1250JIK0A
Human Metabolome Database	HMDB0015342
Guide to Pharmacology	10903
KEGG	C06912
PDB	CTY
PharmGKB	PA449028
PubChem	84029
SureChEMBL	SCHEMBL38125
ZINC	ZINC000085534098

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

CLARITHROMYCIN

Structure

Physicochemical Descriptors

Metabolites Network

Pharmacology

Related Entries

Environmental Exposure

Cross References