CINACALCET HYDROCHLORIDE

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Search structure


Trade Names	CINACALCET HYDROCHLORIDE SENSIPAR
Synonyms	AMG-073 AMG-073 HCL AMG073 HCL AMG073 HYDROCHLORIDE Cinacalcet hcl Cinacalcet hydrochloride Mimpara Sensipar
Status
Molecule Category	Salt-form
UNII	1K860WSG25
EPA CompTox	DTXSID3046792
Parent Compound:	CINACALCET

Structure


InChI Key	QANQWUQOEJZMLL-PKLMIRHRSA-N
Smiles	C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12.Cl
InChI	InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H23ClF3N
Molecular Weight	393.88
AlogP	6.14
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	6.0
Polar Surface Area	12.03
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	26.0

Pharmacology

Mechanism of Action	Action	Reference
Calcium sensing receptor positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family C G protein-coupled receptor Ion receptor (family C GPCR) Calcium sensing receptor Calcium sensing receptor	19.95-180	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	180	-	-	-	-

Target Conservation


Protein: Calcium sensing receptor Description: Extracellular calcium-sensing receptor Organism : Homo sapiens P41180 ENSG00000036828

Cross References

Resources	Reference
ChEBI	48391
ChEMBL	CHEMBL1200776
FDA SRS	1K860WSG25
KEGG	D03504
PubChem	156418
SureChEMBL	SCHEMBL133710
ZINC	ZINC01550499

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025