CIDOFOVIR

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Trade Names
Synonyms
Status
Molecule Category Free-form
ATC J05AB12
UNII 768M1V522C
EPA CompTox DTXSID3043734

Structure

InChI Key VWFCHDSQECPREK-LURJTMIESA-N
Smiles Nc1ccn(C[C@@H](CO)OCP(=O)(O)O)c(=O)n1
InChI
InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C8H14N3O6P
Molecular Weight 279.19
AlogP -1.66
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 6.0
Polar Surface Area 147.9
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 18.0

Pharmacology

Mechanism of Action Action Reference
Human herpesvirus 1 DNA polymerase inhibitor INHIBITOR PubMed
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cytomegalovirus
430-940 - - - -
Homo sapiens
160-600 500 - - -
Human adenovirus 5
- - - - 3.51
Human betaherpesvirus 5
340-980 - - - -
Human herpesvirus 1
570-930 - - - -
Human herpesvirus 1 strain KOS
400-900 - - - -
Human herpesvirus 2 strain G
700-900 - - - -
Human herpesvirus 3
44-500 - - - -
Human herpesvirus 3 strain Oka vaccine
290-290 - - - -
Human herpesvirus 4
480 - - - -
Human herpesvirus 5
69-940 60-900 - - -
Human herpesvirus 5 strain AD169
45-920 980 - - -
Human herpesvirus 5 strain Towne
- 110-280 - - -
Human herpesvirus 8
64 - - - -
Murid herpesvirus 1
40 - - - -
Vaccinia virus WR
- - - - 94.6

Related Entries

Cross References

Resources Reference
ChEBI 3696
ChEMBL CHEMBL152
DrugBank DB00369
DrugCentral 639
FDA SRS 768M1V522C
Human Metabolome Database HMDB0014513
PDB L8P
PharmGKB PA448997
PubChem 60933
SureChEMBL SCHEMBL3948
ZINC ZINC000001530600
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