CHLORPHENIRAMINE MALEATE


Trade Names	ANTAGONATE CHLOR-TRIMETON CHLORPHENIRAMINE MALEATE EFIDAC 24 CHLORPHENIRAMINE MALEATE KLOROMIN PHENETRON PYRIDAMAL 100 TELDRIN
Synonyms	(+)-Chlorpheniramine Maleate Allercalm allergy relief Allerief Alunex Antagonate Calimal Chlor-trimeton Chlorphenamine Chlorphenamine hydrogen maleate Chlorphenamine maleate Chlorphenamini hydrogenomaleas Chlorpheniramine Maleate Chlorpheniramine maleate Chlorprophenpyridamine maleate Efidac Efidac 24 chlorpheniramine maleate Hayleve Histaspan Kloromin NSC-756684 Neorestamin Phenetron Piriject Piriton Piriton allergy Pyridamal Pyridamal 100 Rhino-syrup allergy Rimarin Synistamin Teldrin
Status
Molecule Category	Mixture
UNII	V1Q0O9OJ9Z
EPA CompTox	DTXSID4020321


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	DBAKFASWICGISY-BTJKTKAUSA-N
Smiles	CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
InChI	InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	PubMed PubMed


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	3645
ChEMBL	CHEMBL1659
FDA SRS	V1Q0O9OJ9Z
KEGG	C07780
PubChem	5281068
SureChEMBL	SCHEMBL33357

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects from the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects from the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).