CHLORAMPHENICOL


Trade Names	CHLORAMPHENICOL CHLOROFAIR CHLOROMYCETIN CHLOROPTIC CHLOROPTIC S.O.P. ECONOCHLOR MYCHEL OPHTHOCHLOR OPTOMYCIN
Synonyms	9-hydroxy-9-phenylxanthene 9-phenyl-9h-xanthen-9-ol Amphicol Brochlor Brolene antibiotic Chloramex Chloramphenicol Chlorbiotic Chlorofair Chloromycetin Chloroptic Chloroptic s.o.p. Econochlor Golden eye antibiotic Kemicetine
Status
Molecule Category	Free-form
ATC	D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08
UNII	66974FR9Q1
EPA CompTox	DTXSID7020265


InChI Key	WIIZWVCIJKGZOK-RKDXNWHRSA-N
Smiles	O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
InChI	InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

Property Name	Value
Molecular Formula	C11H12Cl2N2O5
Molecular Weight	323.13
AlogP	0.91
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	112.7
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	20.0

Mechanism of Action	Action	Reference
Bacterial 70S ribosome inhibitor	INHIBITOR	PubMed PubMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Other cytosolic protein	-	430	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	84.74-90.58
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	1.4
Unclassified protein	-	430	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	84.74-90.58
Escherichia coli	-	-	-	700	50-50
Escherichia coli K-12	-	-	-	880	-
Homo sapiens	-	-	-	-	1.4
Staphylococcus aureus	-	430-430	-	-	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Countries
Romania

Resources	Reference
ChEBI	17698
ChEMBL	CHEMBL130
DrugBank	DB00446
DrugCentral	589
FDA SRS	66974FR9Q1
Human Metabolome Database	HMDB0014589
Guide to Pharmacology	10901
KEGG	C00918
PDB	CLM
PubChem	5959
SureChEMBL	SCHEMBL16111
ZINC	ZINC000000113382

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

CHLORAMPHENICOL

Structure

Physicochemical Descriptors

Pharmacology

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