CHLORAMPHENICOL


Trade Names	CHLORAMPHENICOL CHLOROFAIR CHLOROMYCETIN CHLOROPTIC CHLOROPTIC S.O.P. ECONOCHLOR MYCHEL OPHTHOCHLOR OPTOMYCIN
Synonyms	9-hydroxy-9-phenylxanthene 9-phenyl-9h-xanthen-9-ol Amphicol Brochlor Brolene antibiotic Chloramex Chloramphenicol Chlorbiotic Chlorofair Chloromycetin Chloroptic Chloroptic s.o.p. Econochlor Golden eye antibiotic Kemicetine Kernispray Klorafect Mychel Mychel-S NSC-16331 NSC-3069 Ophthochlor Optomycin Sno phenicol Tevcocin Tubilux infected eyes Xanthen-9-ol, 9-phenyl-
Status
Molecule Category	Free-form
ATC	D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08
UNII	66974FR9Q1
EPA CompTox	DTXSID7020265


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	WIIZWVCIJKGZOK-RKDXNWHRSA-N
Smiles	O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
InChI	InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C11H12Cl2N2O5
Molecular Weight	323.13
AlogP	0.91
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	112.7
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	20.0

Pharmacology

Mechanism of Action	Action	Reference
Bacterial 70S ribosome inhibitor	INHIBITOR	PubMed PubMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Ligase	7900	-	-	-	-
Other cytosolic protein	-	430	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	85
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	-	-	-	1
Unclassified protein	-	430	-	-	-

Related Entries

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Environmental Exposure

Environmental Exposure Map

Countries
Romania

Cross References

Resources	Reference
ChEBI	17698
ChEMBL	CHEMBL130
DrugBank	DB00446
DrugCentral	589
FDA SRS	66974FR9Q1
Human Metabolome Database	HMDB0014589
Guide to Pharmacology	10901
KEGG	C00918
PDB	CLM
PubChem	5959
SureChEMBL	SCHEMBL16111
ZINC	ZINC000000113382

CONTENTS


PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains. Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).