CERITINIB


Trade Names	ZYKADIA
Synonyms	Ceritinib Ceritinib[mi] LDK-378 LDK378 NVP-LDK-378-NX NVP-LDK378-NX Zykadia
Status
Molecule Category	Free-form
ATC	L01ED02
UNII	K418KG2GET
EPA CompTox	DTXSID10725373


InChI Key	VERWOWGGCGHDQE-UHFFFAOYSA-N
Smiles	Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1
InChI	InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)

Mechanism of Action	Action	Reference
ALK tyrosine kinase receptor inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase TSSK family	-	23	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family	-	19-900	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	260-950	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase InsR family	-	7-410	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakA family	-	610	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakB family	-	610	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family	-	271	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	60-86.4	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family	-	400	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Sev family	-	2-141.8	-	0.4-230	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	560-840	-	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase STKR family TKL protein kinase STKR Type 1 subfamily	26-190	0.2-810	1.3	-	-
Other nuclear protein	-	26	-	-	-
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	89	-	-	-	-
Unclassified protein	26-190	41-444	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	15-593	0.2-950	1.3	0.4-230	-
Mus musculus	-	7.11-726	-	-	-
Rattus norvegicus	-	-	-	-	80


Protein: NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Description: Nucleophosmin Organism : Homo sapiens P06748 ENSG00000181163





Protein: EML4-ALK Description: Echinoderm microtubule-associated protein-like 4 Organism : Homo sapiens Q9HC35 ENSG00000143924











Protein: ALK tyrosine kinase receptor Description: ALK tyrosine kinase receptor Organism : Homo sapiens Q9UM73 ENSG00000171094











Protein: EML4-ALK Description: ALK tyrosine kinase receptor Organism : Homo sapiens Q9UM73 ENSG00000171094











Protein: NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) Description: ALK tyrosine kinase receptor Organism : Homo sapiens Q9UM73 ENSG00000171094

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