CEFUROXIME SODIUM

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII R8A7M9MY61
Parent Compound: CEFUROXIME

Structure

InChI Key URDOHUPGIOGTKV-JTBFTWTJSA-M
Smiles CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(COC(N)=O)CS[C@H]12)c1ccco1.[Na+]
InChI
InChI=1S/C16H16N4O8S.Na/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20;/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24);/q;+1/p-1/b19-9-;/t10-,14-;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H15N4NaO8S
Molecular Weight 446.37
AlogP -0.54
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 7.0
Polar Surface Area 173.76
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 29.0

Pharmacology

Mechanism of Action Action Reference
Bacterial penicillin-binding protein inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 64.47-83.34
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 64.47-83.34

Cross References

Resources Reference
ChEBI 3517
ChEMBL CHEMBL2146124
FDA SRS R8A7M9MY61
KEGG C08108
PubChem 23670318
SureChEMBL SCHEMBL719536
ZINC ZINC03871978
CONTENTS