CEFOTAXIME SODIUM

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII 258J72S7TZ
Parent Compound: CEFOTAXIME

Structure

InChI Key AZZMGZXNTDTSME-JUZDKLSSSA-M
Smiles CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(COC(C)=O)CS[C@H]12)c1csc(N)n1.[Na+]
InChI
InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H16N5NaO7S2
Molecular Weight 477.46
AlogP -0.62
Hydrogen Bond Acceptor 11.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 7.0
Polar Surface Area 173.51
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 30.0

Pharmacology

Mechanism of Action Action Reference
Bacterial penicillin-binding protein inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 104.13-119.18
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 104.13-119.18

Cross References

Resources Reference
ChEBI 3498
ChEMBL CHEMBL1010
FDA SRS 258J72S7TZ
KEGG C08113
PubChem 10695961
SureChEMBL SCHEMBL41092
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