EcoDrugPlus


Trade Names	BUTENAFINE HYDROCHLORIDE LOTRIMIN ULTRA MENTAX MENTAX-TC
Synonyms	Butenafine hcl Butenafine hydrochloride KP-363 Lotrimin ultra Mentax Mentax-tc
Status
Molecule Category	Salt-form
UNII	R8XA2029ZI
EPA CompTox	DTXSID2048589

Trade Names

BUTENAFINE HYDROCHLORIDE

LOTRIMIN ULTRA

MENTAX

MENTAX-TC

Synonyms

Butenafine hcl

Butenafine hydrochloride

KP-363

Lotrimin ultra

Mentax

Mentax-tc

Status

Molecule Category

Salt-form

UNII

R8XA2029ZI

EPA CompTox

DTXSID2048589


InChI Key	LJBSAUIFGPSHCN-UHFFFAOYSA-N
Smiles	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12.Cl
InChI	InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H

InChI Key

LJBSAUIFGPSHCN-UHFFFAOYSA-N

Smiles

CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12.Cl

InChI

InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H

Property Name	Value
Molecular Formula	C23H28ClN
Molecular Weight	353.94
AlogP	5.77
Hydrogen Bond Acceptor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	3.24
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	24.0

Property Name

Value

Molecular Formula

C23H28ClN

Molecular Weight

353.94

AlogP

5.77

Hydrogen Bond Acceptor

1.0

Number of Rotational Bond

4.0

Polar Surface Area

3.24

Molecular species

BASE

Aromatic Rings

3.0

Heavy Atoms

24.0

Mechanism of Action	Action	Reference
Squalene monooxygenase inhibitor	INHIBITOR	PubMed PubMed Wikipedia

Mechanism of Action

Action

Reference

Squalene monooxygenase inhibitor

INHIBITOR

PubMed PubMed Wikipedia

Resources	Reference
ChEBI	31325
ChEMBL	CHEMBL1200397
FDA SRS	R8XA2029ZI
KEGG	C12490
PubChem	443867
SureChEMBL	SCHEMBL262301
ZINC	ZINC01530975

Resources

Reference

ChEBI

ChEMBL

FDA SRS

KEGG

PubChem

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

BUTENAFINE HYDROCHLORIDE

Structure

Physicochemical Descriptors

Pharmacology

Cross References