BUPROPION HYDROCHLORIDE

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Search structure


Trade Names	BUPROPION HYDROCHLORIDE FORFIVO XL WELLBUTRIN WELLBUTRIN SR WELLBUTRIN XL ZYBAN
Synonyms	Amfebutamone hydrochloride BW 323 BW-323 Bupropion HCl Bupropion hcl Bupropion hydrochloride Forfivo xl Mysimba NSC-315851 Wellbutrin Wellbutrin 100 Wellbutrin 75 Wellbutrin sr Wellbutrin xl Zyban
Status
Molecule Category	Salt-form
UNII	ZG7E5POY8O
EPA CompTox	DTXSID6044561
Parent Compound:	BUPROPION

Structure


InChI Key	HEYVINCGKDONRU-UHFFFAOYSA-N
Smiles	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1.Cl
InChI	InChI=1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C13H19Cl2NO
Molecular Weight	276.21
AlogP	3.3
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	29.1
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	16.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine transporter inhibitor	INHIBITOR	PubMed DailyMed

Target Conservation


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Dopamine transporter Description: Sodium-dependent dopamine transporter Organism : Homo sapiens Q01959 ENSG00000142319

Cross References

Resources	Reference
ChEBI	3220
ChEMBL	CHEMBL1698
FDA SRS	ZG7E5POY8O
PubChem	62884
SureChEMBL	SCHEMBL41602

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025