EcoDrugPlus


Trade Names	MIRADON
Synonyms	Anisindione Miradon NSC-759629
Status
Molecule Category	Free-form
UNII	S747T1ERAJ
EPA CompTox	DTXSID3022611


InChI Key	XRCFXMGQEVUZFC-UHFFFAOYSA-N
Smiles	COc1ccc(C2C(=O)c3ccccc3C2=O)cc1
InChI	InChI=1S/C16H12O3/c1-19-11-8-6-10(7-9-11)14-15(17)12-4-2-3-5-13(12)16(14)18/h2-9,14H,1H3

Property Name	Value
Molecular Formula	C16H12O3
Molecular Weight	252.27
AlogP	2.86
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	43.37
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	19.0

Mechanism of Action	Action	Reference
Vitamin K-dependent gamma-carboxylase inhibitor	INHIBITOR	ISBN PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	0-1.3
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	74.63-75.63

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	0-1.3
Cricetulus griseus	-	-	-	-	74.63-75.63

Resources	Reference
ChEBI	133809
ChEMBL	CHEMBL712
DrugBank	DB01125
DrugCentral	222
FDA SRS	S747T1ERAJ
Human Metabolome Database	HMDB0015257
Guide to Pharmacology	6960
KEGG	D07457
PharmGKB	PA164746467
PubChem	2197
SureChEMBL	SCHEMBL49379
ZINC	ZINC000100015486

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

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Pharmacology

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