ACETOHEXAMIDE


Trade Names	ACETOHEXAMIDE DYMELOR
Synonyms	33006 Acetohexamide Dimelor Dymelor NSC-759128
Status
Molecule Category	Free-form
ATC	A10BB31
UNII	QGC8W08I6I
EPA CompTox	DTXSID7020007


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	VGZSUPCWNCWDAN-UHFFFAOYSA-N
Smiles	CC(=O)c1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1
InChI	InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

Mechanism of Action	Action	Reference
Sulfonylurea receptor 1, Kir6.2 blocker	BLOCKER	PubMed PubMed Wikipedia


Protein: Sulfonylurea receptor 1, Kir6.2 Description: ATP-binding cassette sub-family C member 8 Organism : Homo sapiens Q09428 ENSG00000006071











Protein: Sulfonylurea receptor 1, Kir6.2 Description: ATP-sensitive inward rectifier potassium channel 11 Organism : Homo sapiens Q14654 ENSG00000187486

Assay Description	Organism	Bioactivity
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	-2.16 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	15.64 %	SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	9.27 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.06 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.12 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.12 %	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	0.06 %

Countries
Vietnam

CONTENTS