Gene: P2RY1
Ensembl ID : ENSG00000169860
Description: purinergic receptor P2Y1
Gene Synonyms: P2Y1,SARCC
1 APIs:
191 Possible Orthologues:

GPCR ligand binding R-HSA-500792
Signal amplification R-HSA-392518
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Nucleotide-like (purinergic) receptors R-HSA-418038
Hemostasis R-HSA-109582
P2Y receptors R-HSA-417957
G alpha (q) signalling events R-HSA-416476
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Nucleotide-like (purinergic) receptors R-HSA-418038
Platelet activation, signaling and aggregation R-HSA-76002
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Signal amplification R-HSA-392518
G alpha (q) signalling events R-HSA-416476
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Hemostasis R-HSA-109582
Signaling by GPCR R-HSA-372790
P2Y receptors R-HSA-417957
P2Y receptors R-HSA-417957
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Platelet activation, signaling and aggregation R-HSA-76002
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Signal amplification R-HSA-392518
Hemostasis R-HSA-109582
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
Nucleotide-like (purinergic) receptors R-HSA-418038
Signal Transduction R-HSA-162582
Nucleotide-like (purinergic) receptors R-HSA-418038
GPCR downstream signalling R-HSA-388396
Signal amplification R-HSA-392518
Platelet activation, signaling and aggregation R-HSA-76002
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
P2Y receptors R-HSA-417957
Hemostasis R-HSA-109582
G alpha (q) signalling events R-HSA-416476
Signaling by GPCR R-HSA-372790
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Hemostasis R-HSA-109582
P2Y receptors R-HSA-417957
G alpha (q) signalling events R-HSA-416476
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Nucleotide-like (purinergic) receptors R-HSA-418038
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Signal amplification R-HSA-392518
Platelet activation, signaling and aggregation R-HSA-76002
GPCR ligand binding R-HSA-500792
Platelet activation, signaling and aggregation R-HSA-76002
Signal Transduction R-HSA-162582
Hemostasis R-HSA-109582
P2Y receptors R-HSA-417957
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
Signal amplification R-HSA-392518
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Nucleotide-like (purinergic) receptors R-HSA-418038
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Platelet activation, signaling and aggregation R-HSA-76002
GPCR ligand binding R-HSA-500792
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
G alpha (q) signalling events R-HSA-416476
Hemostasis R-HSA-109582
GPCR downstream signalling R-HSA-388396
Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790
P2Y receptors R-HSA-417957
Signal amplification R-HSA-392518
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Signal amplification R-HSA-392518
P2Y receptors R-HSA-417957
Hemostasis R-HSA-109582
Platelet activation, signaling and aggregation R-HSA-76002
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Nucleotide-like (purinergic) receptors R-HSA-418038
GPCR ligand binding R-HSA-500792
Hemostasis R-HSA-109582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Signal Transduction R-HSA-162582
Signal amplification R-HSA-392518
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Nucleotide-like (purinergic) receptors R-HSA-418038
P2Y receptors R-HSA-417957
Platelet activation, signaling and aggregation R-HSA-76002
G alpha (q) signalling events R-HSA-416476
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
Platelet activation, signaling and aggregation R-HSA-76002
ADP signalling through P2Y purinoceptor 1 R-HSA-418592
Signal amplification R-HSA-392518
P2Y receptors R-HSA-417957
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Hemostasis R-HSA-109582
GPCR ligand binding R-HSA-500792
Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790

Expression Atlas ENSG00000169860
LRG display in Ensembl gene LRG_635
NCBI gene (formerly Entrezgene) 5028
GeneCards 8539
HGNC Symbol HGNC:8539
MIM gene 601167
UniProtKB Gene Name P47900
WikiGene 5028
Gene: P2RY12
Ensembl ID : ENSG00000169313
Description: purinergic receptor P2Y12
Gene Synonyms: HORK3,P2Y12,SP1999
8 APIs:
182 Possible Orthologues:

GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Hemostasis R-HSA-109582
G alpha (i) signalling events R-HSA-418594
P2Y receptors R-HSA-417957
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Signal Transduction R-HSA-162582
Platelet activation, signaling and aggregation R-HSA-76002
Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790
Signal amplification R-HSA-392518
Signal amplification R-HSA-392518
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Nucleotide-like (purinergic) receptors R-HSA-418038
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Platelet activation, signaling and aggregation R-HSA-76002
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
P2Y receptors R-HSA-417957
G alpha (i) signalling events R-HSA-418594
Hemostasis R-HSA-109582
Signal amplification R-HSA-392518
P2Y receptors R-HSA-417957
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
G alpha (i) signalling events R-HSA-418594
Hemostasis R-HSA-109582
GPCR ligand binding R-HSA-500792
Platelet activation, signaling and aggregation R-HSA-76002
Platelet activation, signaling and aggregation R-HSA-76002
Signal Transduction R-HSA-162582
Signal amplification R-HSA-392518
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Nucleotide-like (purinergic) receptors R-HSA-418038
Hemostasis R-HSA-109582
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (i) signalling events R-HSA-418594
P2Y receptors R-HSA-417957
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
P2Y receptors R-HSA-417957
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Hemostasis R-HSA-109582
Nucleotide-like (purinergic) receptors R-HSA-418038
G alpha (i) signalling events R-HSA-418594
GPCR ligand binding R-HSA-500792
Platelet activation, signaling and aggregation R-HSA-76002
Signal amplification R-HSA-392518
Signal Transduction R-HSA-162582
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
P2Y receptors R-HSA-417957
Signal amplification R-HSA-392518
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Hemostasis R-HSA-109582
Signaling by GPCR R-HSA-372790
Platelet activation, signaling and aggregation R-HSA-76002
G alpha (i) signalling events R-HSA-418594
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Nucleotide-like (purinergic) receptors R-HSA-418038
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
G alpha (i) signalling events R-HSA-418594
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Platelet activation, signaling and aggregation R-HSA-76002
Nucleotide-like (purinergic) receptors R-HSA-418038
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Hemostasis R-HSA-109582
Signal amplification R-HSA-392518
P2Y receptors R-HSA-417957
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Hemostasis R-HSA-109582
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Platelet activation, signaling and aggregation R-HSA-76002
Signal amplification R-HSA-392518
G alpha (i) signalling events R-HSA-418594
Nucleotide-like (purinergic) receptors R-HSA-418038
P2Y receptors R-HSA-417957
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Platelet activation, signaling and aggregation R-HSA-76002
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790
P2Y receptors R-HSA-417957
Signal amplification R-HSA-392518
G alpha (i) signalling events R-HSA-418594
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Hemostasis R-HSA-109582
GPCR downstream signalling R-HSA-388396
P2Y receptors R-HSA-417957
Signal Transduction R-HSA-162582
ADP signalling through P2Y purinoceptor 12 R-HSA-392170
Platelet activation, signaling and aggregation R-HSA-76002
Signal amplification R-HSA-392518
Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
Hemostasis R-HSA-109582
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076

Expression Atlas ENSG00000169313
LRG display in Ensembl gene LRG_569
NCBI gene (formerly Entrezgene) 64805
GeneCards 18124
HGNC Symbol HGNC:18124
MIM gene 600515
MIM morbid 609821
UniProtKB Gene Name Q9H244
WikiGene 64805
Gene: P2RY6
Ensembl ID : ENSG00000171631
Description: pyrimidinergic receptor P2Y6
Gene Synonyms: P2Y6
1 APIs:
183 Possible Orthologues:

Nucleotide-like (purinergic) receptors R-HSA-418038
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
P2Y receptors R-HSA-417957
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Nucleotide-like (purinergic) receptors R-HSA-418038
G alpha (q) signalling events R-HSA-416476
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
P2Y receptors R-HSA-417957
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
P2Y receptors R-HSA-417957
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Nucleotide-like (purinergic) receptors R-HSA-418038
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Nucleotide-like (purinergic) receptors R-HSA-418038
G alpha (q) signalling events R-HSA-416476
P2Y receptors R-HSA-417957
P2Y receptors R-HSA-417957
GPCR ligand binding R-HSA-500792
Nucleotide-like (purinergic) receptors R-HSA-418038
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
P2Y receptors R-HSA-417957
Nucleotide-like (purinergic) receptors R-HSA-418038
G alpha (q) signalling events R-HSA-416476
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Nucleotide-like (purinergic) receptors R-HSA-418038
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
P2Y receptors R-HSA-417957
G alpha (q) signalling events R-HSA-416476
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Nucleotide-like (purinergic) receptors R-HSA-418038
P2Y receptors R-HSA-417957
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
P2Y receptors R-HSA-417957
Nucleotide-like (purinergic) receptors R-HSA-418038
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Nucleotide-like (purinergic) receptors R-HSA-418038
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
P2Y receptors R-HSA-417957

Expression Atlas ENSG00000171631
NCBI gene (formerly Entrezgene) 5031
GeneCards 8543
HGNC Symbol HGNC:8543
MIM gene 602451
UniProtKB Gene Name Q15077
WikiGene 5031
Gene: PTPRB
Ensembl ID : ENSG00000127329
Description: protein tyrosine phosphatase receptor type B
Gene Synonyms: PTPB
1 APIs:
268 Possible Orthologues:

Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249

Expression Atlas ENSG00000127329
NCBI gene (formerly Entrezgene) 5787
GeneCards 9665
HGNC Symbol HGNC:9665
MIM gene 176882
UniProtKB Gene Name Q6ZR19
WikiGene 5787
Gene: SLC29A1
Ensembl ID : ENSG00000112759
Description: solute carrier family 29 member 1 (Augustine blood group)
Gene Synonyms: ENT1
1 APIs:
280 Possible Orthologues:

Azathioprine ADME R-HSA-9748787
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
SLC-mediated transmembrane transport R-HSA-425407
Ribavirin ADME R-HSA-9755088
Transport of small molecules R-HSA-382551
Drug ADME R-HSA-9748784
SLC-mediated transmembrane transport R-HSA-425407
Ribavirin ADME R-HSA-9755088
Drug ADME R-HSA-9748784
Azathioprine ADME R-HSA-9748787
Transport of small molecules R-HSA-382551
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of small molecules R-HSA-382551
Azathioprine ADME R-HSA-9748787
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Drug ADME R-HSA-9748784
Ribavirin ADME R-HSA-9755088
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Drug ADME R-HSA-9748784
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Azathioprine ADME R-HSA-9748787
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Ribavirin ADME R-HSA-9755088
SLC-mediated transmembrane transport R-HSA-425407
Azathioprine ADME R-HSA-9748787
Transport of small molecules R-HSA-382551
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Drug ADME R-HSA-9748784
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Ribavirin ADME R-HSA-9755088
Azathioprine ADME R-HSA-9748787
Drug ADME R-HSA-9748784
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Ribavirin ADME R-HSA-9755088
Drug ADME R-HSA-9748784
Azathioprine ADME R-HSA-9748787
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
SLC-mediated transmembrane transport R-HSA-425407
Drug ADME R-HSA-9748784
Transport of small molecules R-HSA-382551
Azathioprine ADME R-HSA-9748787
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Drug ADME R-HSA-9748784
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
SLC-mediated transmembrane transport R-HSA-425407
Azathioprine ADME R-HSA-9748787
Transport of small molecules R-HSA-382551
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of small molecules R-HSA-382551
Drug ADME R-HSA-9748784
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Azathioprine ADME R-HSA-9748787
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Drug ADME R-HSA-9748784
Azathioprine ADME R-HSA-9748787
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Ribavirin ADME R-HSA-9755088
Transport of small molecules R-HSA-382551

Expression Atlas ENSG00000112759
LRG display in Ensembl gene LRG_1027
NCBI gene (formerly Entrezgene) 2030
GeneCards 11003
HGNC Symbol HGNC:11003
MIM gene 602193
UniProtKB Gene Name Q99808
WikiGene 2030
Gene: MAP3K5
Ensembl ID : ENSG00000197442
Description: mitogen-activated protein kinase kinase kinase 5
Gene Synonyms: ASK1,MAPKKK5,MEKK5
1 APIs:
209 Possible Orthologues:

Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular responses to stress R-HSA-2262752
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752

Expression Atlas ENSG00000197442
NCBI gene (formerly Entrezgene) 4217
GeneCards 6857
HGNC Symbol HGNC:6857
MIM gene 602448
UniProtKB Gene Name Q99683
WikiGene 4217
Gene: MAP3K1
Ensembl ID : ENSG00000095015
Description: mitogen-activated protein kinase kinase kinase 1
Gene Synonyms: MAPKKK1,MEKK,MEKK1
1 APIs:
160 Possible Orthologues:

Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Innate Immune System R-HSA-168249
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
FCERI mediated MAPK activation R-HSA-2871796
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRAF6 mediated NF-kB activation R-HSA-933542
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll-like Receptor Cascades R-HSA-168898
Immune System R-HSA-168256
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Immune System R-HSA-168256
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
TRAF6 mediated NF-kB activation R-HSA-933542
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
FCERI mediated MAPK activation R-HSA-2871796
Innate Immune System R-HSA-168249
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Innate Immune System R-HSA-168249
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll-like Receptor Cascades R-HSA-168898
Immune System R-HSA-168256
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated NF-kB activation R-HSA-933542
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
FCERI mediated MAPK activation R-HSA-2871796
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRAF6 mediated NF-kB activation R-HSA-933542
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MyD88 cascade initiated on plasma membrane R-HSA-975871
FCERI mediated MAPK activation R-HSA-2871796
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll-like Receptor Cascades R-HSA-168898
Immune System R-HSA-168256
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88 dependent cascade initiated on endosome R-HSA-975155
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Innate Immune System R-HSA-168249
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Immune System R-HSA-168256
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88 cascade initiated on plasma membrane R-HSA-975871
FCERI mediated MAPK activation R-HSA-2871796
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
MyD88 dependent cascade initiated on endosome R-HSA-975155
Innate Immune System R-HSA-168249
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRAF6 mediated NF-kB activation R-HSA-933542
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Immune System R-HSA-168256
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
FCERI mediated MAPK activation R-HSA-2871796
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Innate Immune System R-HSA-168249
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated NF-kB activation R-HSA-933542
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
TRAF6 mediated NF-kB activation R-HSA-933542
Innate Immune System R-HSA-168249
FCERI mediated MAPK activation R-HSA-2871796
MyD88 cascade initiated on plasma membrane R-HSA-975871
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Immune System R-HSA-168256
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Immune System R-HSA-168256
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRAF6 mediated NF-kB activation R-HSA-933542
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
FCERI mediated MAPK activation R-HSA-2871796
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Innate Immune System R-HSA-168249
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRAF6 mediated NF-kB activation R-HSA-933542
Immune System R-HSA-168256
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
FCERI mediated MAPK activation R-HSA-2871796
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Innate Immune System R-HSA-168249
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll-like Receptor Cascades R-HSA-168898
TRAF6 mediated NF-kB activation R-HSA-933542
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MyD88 dependent cascade initiated on endosome R-HSA-975155
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Innate Immune System R-HSA-168249
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
FCERI mediated MAPK activation R-HSA-2871796
Immune System R-HSA-168256
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138

Expression Atlas ENSG00000095015
NCBI gene (formerly Entrezgene) 4214
GeneCards 6848
HGNC Symbol HGNC:6848
MIM gene 600982
MIM morbid 613762
UniProtKB Gene Name Q13233
WikiGene 4214
Gene: PAK4
Ensembl ID : ENSG00000130669
Description: p21 (RAC1) activated kinase 4
Gene Synonyms:
1 APIs:
160 Possible Orthologues:

RHOV GTPase cycle R-HSA-9013424
RHOH GTPase cycle R-HSA-9013407
Developmental Biology R-HSA-1266738
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
Activation of RAC1 R-HSA-428540
RAC2 GTPase cycle R-HSA-9013404
RHO GTPase cycle R-HSA-9012999
Nervous system development R-HSA-9675108
RHOJ GTPase cycle R-HSA-9013409
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHOQ GTPase cycle R-HSA-9013406
Signal Transduction R-HSA-162582
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
RHOG GTPase cycle R-HSA-9013408
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC2 GTPase cycle R-HSA-9013404
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
RHOV GTPase cycle R-HSA-9013424
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
Developmental Biology R-HSA-1266738
Activation of RAC1 R-HSA-428540
CDC42 GTPase cycle R-HSA-9013148
RHOU GTPase cycle R-HSA-9013420
RAC1 GTPase cycle R-HSA-9013149
RHOJ GTPase cycle R-HSA-9013409
Signaling by ROBO receptors R-HSA-376176
RHOH GTPase cycle R-HSA-9013407
RHOQ GTPase cycle R-HSA-9013406
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
RHOJ GTPase cycle R-HSA-9013409
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
RHOG GTPase cycle R-HSA-9013408
RHOV GTPase cycle R-HSA-9013424
CDC42 GTPase cycle R-HSA-9013148
Signal Transduction R-HSA-162582
RAC2 GTPase cycle R-HSA-9013404
RHO GTPase cycle R-HSA-9012999
Nervous system development R-HSA-9675108
RHOQ GTPase cycle R-HSA-9013406
RHOU GTPase cycle R-HSA-9013420
Activation of RAC1 R-HSA-428540
Signaling by ROBO receptors R-HSA-376176
RHOH GTPase cycle R-HSA-9013407
Axon guidance R-HSA-422475
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
RHOJ GTPase cycle R-HSA-9013409
RHO GTPase cycle R-HSA-9012999
Activation of RAC1 R-HSA-428540
RAC1 GTPase cycle R-HSA-9013149
RAC3 GTPase cycle R-HSA-9013423
RHOG GTPase cycle R-HSA-9013408
RHOH GTPase cycle R-HSA-9013407
Signaling by Rho GTPases R-HSA-194315
Nervous system development R-HSA-9675108
RAC2 GTPase cycle R-HSA-9013404
Signal Transduction R-HSA-162582
Signaling by ROBO receptors R-HSA-376176
Developmental Biology R-HSA-1266738
RHOV GTPase cycle R-HSA-9013424
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOU GTPase cycle R-HSA-9013420
RHOQ GTPase cycle R-HSA-9013406
Signal Transduction R-HSA-162582
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC2 GTPase cycle R-HSA-9013404
RHOH GTPase cycle R-HSA-9013407
Activation of RAC1 R-HSA-428540
Signaling by Rho GTPases R-HSA-194315
RAC1 GTPase cycle R-HSA-9013149
RHOG GTPase cycle R-HSA-9013408
RHOV GTPase cycle R-HSA-9013424
RHOU GTPase cycle R-HSA-9013420
RHOJ GTPase cycle R-HSA-9013409
RAC3 GTPase cycle R-HSA-9013423
RHO GTPase cycle R-HSA-9012999
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
RHOQ GTPase cycle R-HSA-9013406
RAC3 GTPase cycle R-HSA-9013423
Signaling by ROBO receptors R-HSA-376176
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
Signaling by Rho GTPases R-HSA-194315
CDC42 GTPase cycle R-HSA-9013148
RAC1 GTPase cycle R-HSA-9013149
RHOJ GTPase cycle R-HSA-9013409
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Activation of RAC1 R-HSA-428540
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
RHOV GTPase cycle R-HSA-9013424
RHOQ GTPase cycle R-HSA-9013406
RAC2 GTPase cycle R-HSA-9013404
RHOH GTPase cycle R-HSA-9013407
RHO GTPase cycle R-HSA-9012999
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RHOQ GTPase cycle R-HSA-9013406
Activation of RAC1 R-HSA-428540
RHOG GTPase cycle R-HSA-9013408
RHOH GTPase cycle R-HSA-9013407
RHOU GTPase cycle R-HSA-9013420
Signal Transduction R-HSA-162582
RAC2 GTPase cycle R-HSA-9013404
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases R-HSA-194315
Nervous system development R-HSA-9675108
RHOJ GTPase cycle R-HSA-9013409
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOV GTPase cycle R-HSA-9013424
RAC3 GTPase cycle R-HSA-9013423
Axon guidance R-HSA-422475
RHOQ GTPase cycle R-HSA-9013406
RHOH GTPase cycle R-HSA-9013407
CDC42 GTPase cycle R-HSA-9013148
Nervous system development R-HSA-9675108
Activation of RAC1 R-HSA-428540
RAC3 GTPase cycle R-HSA-9013423
Signal Transduction R-HSA-162582
Signaling by ROBO receptors R-HSA-376176
RHOV GTPase cycle R-HSA-9013424
RHOG GTPase cycle R-HSA-9013408
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHO GTPase cycle R-HSA-9012999
RHOJ GTPase cycle R-HSA-9013409
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases R-HSA-194315
RAC1 GTPase cycle R-HSA-9013149
RHOU GTPase cycle R-HSA-9013420
RAC2 GTPase cycle R-HSA-9013404
Axon guidance R-HSA-422475
RHOU GTPase cycle R-HSA-9013420
RAC1 GTPase cycle R-HSA-9013149
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
Developmental Biology R-HSA-1266738
RHOJ GTPase cycle R-HSA-9013409
Activation of RAC1 R-HSA-428540
Signal Transduction R-HSA-162582
RHOH GTPase cycle R-HSA-9013407
RHOQ GTPase cycle R-HSA-9013406
RAC2 GTPase cycle R-HSA-9013404
RHOG GTPase cycle R-HSA-9013408
RAC3 GTPase cycle R-HSA-9013423
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RHOV GTPase cycle R-HSA-9013424
Nervous system development R-HSA-9675108

Expression Atlas ENSG00000130669
NCBI gene (formerly Entrezgene) 10298
GeneCards 16059
HGNC Symbol HGNC:16059
MIM gene 605451
UniProtKB Gene Name O96013
WikiGene 10298