Gene: GUCY1A1
Ensembl ID : ENSG00000164116
Description: guanylate cyclase 1 soluble subunit alpha 1
Gene Synonyms: GC-SA3,GUC1A3,GUCY1A3
13 APIs:
203 Possible Orthologues:

Platelet homeostasis R-HSA-418346
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Muscle contraction R-HSA-397014
Hemostasis R-HSA-109582
Smooth Muscle Contraction R-HSA-445355
Muscle contraction R-HSA-397014
Platelet homeostasis R-HSA-418346
Smooth Muscle Contraction R-HSA-445355
Hemostasis R-HSA-109582
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Muscle contraction R-HSA-397014
Platelet homeostasis R-HSA-418346
Smooth Muscle Contraction R-HSA-445355
Hemostasis R-HSA-109582
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Hemostasis R-HSA-109582
Platelet homeostasis R-HSA-418346
Muscle contraction R-HSA-397014
Smooth Muscle Contraction R-HSA-445355
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Smooth Muscle Contraction R-HSA-445355
Muscle contraction R-HSA-397014
Hemostasis R-HSA-109582
Platelet homeostasis R-HSA-418346
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Smooth Muscle Contraction R-HSA-445355
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Hemostasis R-HSA-109582
Muscle contraction R-HSA-397014
Platelet homeostasis R-HSA-418346
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Muscle contraction R-HSA-397014
Platelet homeostasis R-HSA-418346
Smooth Muscle Contraction R-HSA-445355
Hemostasis R-HSA-109582
Hemostasis R-HSA-109582
Smooth Muscle Contraction R-HSA-445355
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Muscle contraction R-HSA-397014
Platelet homeostasis R-HSA-418346
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Platelet homeostasis R-HSA-418346
Hemostasis R-HSA-109582
Muscle contraction R-HSA-397014
Smooth Muscle Contraction R-HSA-445355
Hemostasis R-HSA-109582
Smooth Muscle Contraction R-HSA-445355
Muscle contraction R-HSA-397014
Nitric oxide stimulates guanylate cyclase R-HSA-392154
Platelet homeostasis R-HSA-418346

Expression Atlas ENSG00000164116
NCBI gene (formerly Entrezgene) 2982
GeneCards 4685
HGNC Symbol HGNC:4685
MIM gene 139396
MIM morbid 615750
UniProtKB Gene Name Q6PJR4
WikiGene 2982
Gene: EGFR
Ensembl ID : ENSG00000146648
Description: epidermal growth factor receptor
Gene Synonyms: ERBB,ERBB1,ERRP
73 APIs:
286 Possible Orthologues:

Disease R-HSA-1643685
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
Downregulation of ERBB2 signaling R-HSA-8863795
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
Signaling by ERBB2 ECD mutants R-HSA-9665348
L1CAM interactions R-HSA-373760
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
HCMV Early Events R-HSA-9609690
GRB2 events in EGFR signaling R-HSA-179812
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PIP3 activates AKT signaling R-HSA-1257604
Membrane Trafficking R-HSA-199991
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
PI3K events in ERBB2 signaling R-HSA-1963642
Gene expression (Transcription) R-HSA-74160
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by Nuclear Receptors R-HSA-9006931
ESR-mediated signaling R-HSA-8939211
Developmental Biology R-HSA-1266738
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Intracellular signaling by second messengers R-HSA-9006925
Signal transduction by L1 R-HSA-445144
Extra-nuclear estrogen signaling R-HSA-9009391
Nervous system development R-HSA-9675108
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Signaling by PTK6 R-HSA-8848021
EGFR Transactivation by Gastrin R-HSA-2179392
G alpha (q) signalling events R-HSA-416476
Axon guidance R-HSA-422475
HCMV Infection R-HSA-9609646
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by EGFRvIII in Cancer R-HSA-5637812
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by GPCR R-HSA-372790
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Signal Transduction R-HSA-162582
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by ERBB2 in Cancer R-HSA-1227990
ERBB2 Regulates Cell Motility R-HSA-6785631
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by ERBB4 R-HSA-1236394
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR in Cancer R-HSA-1643713
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 KD Mutants R-HSA-9664565
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by NOTCH3 R-HSA-9012852
PTK6 promotes HIF1A stabilization R-HSA-8857538
GPCR downstream signalling R-HSA-388396
Infectious disease R-HSA-5663205
SHC1 events in ERBB2 signaling R-HSA-1250196
SHC1 events in EGFR signaling R-HSA-180336
Vesicle-mediated transport R-HSA-5653656
GAB1 signalosome R-HSA-180292
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K/AKT Signaling in Cancer R-HSA-2219528
PLCG1 events in ERBB2 signaling R-HSA-1251932
EGFR downregulation R-HSA-182971
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB2 R-HSA-1227986
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by EGFR R-HSA-177929
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by NOTCH R-HSA-157118
Generic Transcription Pathway R-HSA-212436
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SHC1 events in ERBB2 signaling R-HSA-1250196
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by ERBB2 R-HSA-1227986
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by PTK6 R-HSA-8848021
GPCR downstream signalling R-HSA-388396
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
PI3K/AKT Signaling in Cancer R-HSA-2219528
Developmental Biology R-HSA-1266738
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by NOTCH R-HSA-157118
PIP3 activates AKT signaling R-HSA-1257604
Signal transduction by L1 R-HSA-445144
Membrane Trafficking R-HSA-199991
Signaling by ERBB4 R-HSA-1236394
Signaling by EGFRvIII in Cancer R-HSA-5637812
Vesicle-mediated transport R-HSA-5653656
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
L1CAM interactions R-HSA-373760
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by Nuclear Receptors R-HSA-9006931
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
ESR-mediated signaling R-HSA-8939211
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
HCMV Infection R-HSA-9609646
Signaling by ERBB2 in Cancer R-HSA-1227990
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR R-HSA-177929
Signaling by GPCR R-HSA-372790
Axon guidance R-HSA-422475
GRB2 events in ERBB2 signaling R-HSA-1963640
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Infectious disease R-HSA-5663205
Signaling by NOTCH3 R-HSA-9012852
G alpha (q) signalling events R-HSA-416476
MAPK1/MAPK3 signaling R-HSA-5684996
Clathrin-mediated endocytosis R-HSA-8856828
Constitutive Signaling by EGFRvIII R-HSA-5637810
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
EGFR downregulation R-HSA-182971
GAB1 signalosome R-HSA-180292
GRB2 events in EGFR signaling R-HSA-179812
Downregulation of ERBB2 signaling R-HSA-8863795
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Nervous system development R-HSA-9675108
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
RAF/MAP kinase cascade R-HSA-5673001
MAPK family signaling cascades R-HSA-5683057
Extra-nuclear estrogen signaling R-HSA-9009391
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ERBB2 ECD mutants R-HSA-9665348
PTK6 promotes HIF1A stabilization R-HSA-8857538
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
HCMV Early Events R-HSA-9609690
SHC1 events in EGFR signaling R-HSA-180336
PLCG1 events in ERBB2 signaling R-HSA-1251932
Signaling by ERBB2 KD Mutants R-HSA-9664565
Constitutive Signaling by EGFRvIII R-HSA-5637810
Infectious disease R-HSA-5663205
Signaling by Nuclear Receptors R-HSA-9006931
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
SHC1 events in ERBB2 signaling R-HSA-1250196
Signal Transduction R-HSA-162582
PIP3 activates AKT signaling R-HSA-1257604
Nervous system development R-HSA-9675108
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PLCG1 events in ERBB2 signaling R-HSA-1251932
L1CAM interactions R-HSA-373760
EGFR downregulation R-HSA-182971
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by EGFR R-HSA-177929
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by EGFRvIII in Cancer R-HSA-5637812
Axon guidance R-HSA-422475
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
GRB2 events in EGFR signaling R-HSA-179812
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
ESR-mediated signaling R-HSA-8939211
RNA Polymerase II Transcription R-HSA-73857
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by EGFR in Cancer R-HSA-1643713
Negative regulation of the PI3K/AKT network R-HSA-199418
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by ERBB4 R-HSA-1236394
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Downregulation of ERBB2 signaling R-HSA-8863795
Vesicle-mediated transport R-HSA-5653656
GPCR downstream signalling R-HSA-388396
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
Signaling by PTK6 R-HSA-8848021
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
ERBB2 Regulates Cell Motility R-HSA-6785631
Generic Transcription Pathway R-HSA-212436
HCMV Early Events R-HSA-9609690
Signaling by NOTCH R-HSA-157118
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Developmental Biology R-HSA-1266738
Signal transduction by L1 R-HSA-445144
GRB2 events in ERBB2 signaling R-HSA-1963640
MAPK family signaling cascades R-HSA-5683057
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
RAF/MAP kinase cascade R-HSA-5673001
Signaling by ERBB2 ECD mutants R-HSA-9665348
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K events in ERBB2 signaling R-HSA-1963642
Gene expression (Transcription) R-HSA-74160
Membrane Trafficking R-HSA-199991
GAB1 signalosome R-HSA-180292
SHC1 events in EGFR signaling R-HSA-180336
Signaling by ERBB2 R-HSA-1227986
EGFR interacts with phospholipase C-gamma R-HSA-212718
Extra-nuclear estrogen signaling R-HSA-9009391
HCMV Infection R-HSA-9609646
MAPK1/MAPK3 signaling R-HSA-5684996
PTK6 promotes HIF1A stabilization R-HSA-8857538
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by EGFR in Cancer R-HSA-1643713
Constitutive Signaling by EGFRvIII R-HSA-5637810
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Infectious disease R-HSA-5663205
Signaling by GPCR R-HSA-372790
Signaling by ERBB2 KD Mutants R-HSA-9664565
RNA Polymerase II Transcription R-HSA-73857
Nervous system development R-HSA-9675108
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by EGFRvIII in Cancer R-HSA-5637812
G alpha (q) signalling events R-HSA-416476
Axon guidance R-HSA-422475
Vesicle-mediated transport R-HSA-5653656
HCMV Early Events R-HSA-9609690
Signaling by ERBB4 R-HSA-1236394
Signaling by EGFR R-HSA-177929
L1CAM interactions R-HSA-373760
GRB2 events in EGFR signaling R-HSA-179812
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
GAB1 signalosome R-HSA-180292
SHC1 events in EGFR signaling R-HSA-180336
Signaling by PTK6 R-HSA-8848021
PLCG1 events in ERBB2 signaling R-HSA-1251932
PTK6 promotes HIF1A stabilization R-HSA-8857538
PIP3 activates AKT signaling R-HSA-1257604
Gene expression (Transcription) R-HSA-74160
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
RAF/MAP kinase cascade R-HSA-5673001
Signaling by NOTCH R-HSA-157118
Signal transduction by L1 R-HSA-445144
SHC1 events in ERBB2 signaling R-HSA-1250196
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by ERBB2 ECD mutants R-HSA-9665348
Intracellular signaling by second messengers R-HSA-9006925
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Membrane Trafficking R-HSA-199991
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
ERBB2 Regulates Cell Motility R-HSA-6785631
Generic Transcription Pathway R-HSA-212436
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by ERBB2 R-HSA-1227986
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Extra-nuclear estrogen signaling R-HSA-9009391
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Downregulation of ERBB2 signaling R-HSA-8863795
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EGFR downregulation R-HSA-182971
PI3K/AKT Signaling in Cancer R-HSA-2219528
PI3K events in ERBB2 signaling R-HSA-1963642
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by Nuclear Receptors R-HSA-9006931
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
GPCR downstream signalling R-HSA-388396
ESR-mediated signaling R-HSA-8939211
EGFR Transactivation by Gastrin R-HSA-2179392
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
HCMV Infection R-HSA-9609646
Signaling by ERBB2 in Cancer R-HSA-1227990
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Vesicle-mediated transport R-HSA-5653656
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
RAF/MAP kinase cascade R-HSA-5673001
Nervous system development R-HSA-9675108
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SHC1 events in EGFR signaling R-HSA-180336
ERBB2 Regulates Cell Motility R-HSA-6785631
RNA Polymerase II Transcription R-HSA-73857
PI3K/AKT Signaling in Cancer R-HSA-2219528
Generic Transcription Pathway R-HSA-212436
Signaling by ERBB2 ECD mutants R-HSA-9665348
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Signal Transduction R-HSA-162582
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
PLCG1 events in ERBB2 signaling R-HSA-1251932
GAB1 signalosome R-HSA-180292
HCMV Early Events R-HSA-9609690
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by Nuclear Receptors R-HSA-9006931
SHC1 events in ERBB2 signaling R-HSA-1250196
G alpha (q) signalling events R-HSA-416476
Signaling by PTK6 R-HSA-8848021
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signal transduction by L1 R-HSA-445144
Signaling by GPCR R-HSA-372790
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
PTK6 promotes HIF1A stabilization R-HSA-8857538
L1CAM interactions R-HSA-373760
Signaling by NOTCH R-HSA-157118
PI3K events in ERBB2 signaling R-HSA-1963642
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Infectious disease R-HSA-5663205
Signaling by EGFR in Cancer R-HSA-1643713
Disease R-HSA-1643685
ESR-mediated signaling R-HSA-8939211
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by EGFR R-HSA-177929
EGFR downregulation R-HSA-182971
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Developmental Biology R-HSA-1266738
EGFR Transactivation by Gastrin R-HSA-2179392
Intracellular signaling by second messengers R-HSA-9006925
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB2 KD Mutants R-HSA-9664565
Membrane Trafficking R-HSA-199991
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Extra-nuclear estrogen signaling R-HSA-9009391
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
GRB2 events in EGFR signaling R-HSA-179812
Signaling by ERBB4 R-HSA-1236394
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by EGFRvIII in Cancer R-HSA-5637812
Gene expression (Transcription) R-HSA-74160
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB2 R-HSA-1227986
EGFR interacts with phospholipase C-gamma R-HSA-212718
HCMV Infection R-HSA-9609646
GPCR downstream signalling R-HSA-388396
Constitutive Signaling by EGFRvIII R-HSA-5637810
Axon guidance R-HSA-422475
EGFR interacts with phospholipase C-gamma R-HSA-212718
G alpha (q) signalling events R-HSA-416476
Signaling by ERBB4 R-HSA-1236394
SHC1 events in ERBB2 signaling R-HSA-1250196
Gene expression (Transcription) R-HSA-74160
Nervous system development R-HSA-9675108
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by Nuclear Receptors R-HSA-9006931
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Signaling by ERBB2 ECD mutants R-HSA-9665348
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by EGFR R-HSA-177929
Signaling by ERBB2 KD Mutants R-HSA-9664565
RAF/MAP kinase cascade R-HSA-5673001
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
GRB2 events in ERBB2 signaling R-HSA-1963640
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by ERBB2 R-HSA-1227986
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PLCG1 events in ERBB2 signaling R-HSA-1251932
HCMV Early Events R-HSA-9609690
Negative regulation of the PI3K/AKT network R-HSA-199418
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PTK6 promotes HIF1A stabilization R-HSA-8857538
Signaling by ERBB2 in Cancer R-HSA-1227990
Signal transduction by L1 R-HSA-445144
ERBB2 Regulates Cell Motility R-HSA-6785631
MAPK family signaling cascades R-HSA-5683057
Intracellular signaling by second messengers R-HSA-9006925
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
GRB2 events in EGFR signaling R-HSA-179812
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Generic Transcription Pathway R-HSA-212436
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Axon guidance R-HSA-422475
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
ESR-mediated signaling R-HSA-8939211
Signaling by NOTCH R-HSA-157118
Signaling by EGFRvIII in Cancer R-HSA-5637812
Developmental Biology R-HSA-1266738
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by GPCR R-HSA-372790
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by PTK6 R-HSA-8848021
PI3K events in ERBB2 signaling R-HSA-1963642
Infectious disease R-HSA-5663205
L1CAM interactions R-HSA-373760
EGFR downregulation R-HSA-182971
EGFR Transactivation by Gastrin R-HSA-2179392
SHC1 events in EGFR signaling R-HSA-180336
Membrane Trafficking R-HSA-199991
Vesicle-mediated transport R-HSA-5653656
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Constitutive Signaling by EGFRvIII R-HSA-5637810
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by NOTCH3 R-HSA-9012852
Downregulation of ERBB2 signaling R-HSA-8863795
GAB1 signalosome R-HSA-180292
GPCR downstream signalling R-HSA-388396
HCMV Infection R-HSA-9609646
Signaling by Nuclear Receptors R-HSA-9006931
MAPK family signaling cascades R-HSA-5683057
ESR-mediated signaling R-HSA-8939211
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 R-HSA-1227986
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by EGFR in Cancer R-HSA-1643713
HCMV Infection R-HSA-9609646
Membrane Trafficking R-HSA-199991
ERBB2 Regulates Cell Motility R-HSA-6785631
PI3K/AKT Signaling in Cancer R-HSA-2219528
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
SHC1 events in ERBB2 signaling R-HSA-1250196
PTK6 promotes HIF1A stabilization R-HSA-8857538
Signaling by NOTCH R-HSA-157118
GRB2 events in EGFR signaling R-HSA-179812
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Developmental Biology R-HSA-1266738
RAF/MAP kinase cascade R-HSA-5673001
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Vesicle-mediated transport R-HSA-5653656
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by ERBB2 in Cancer R-HSA-1227990
Constitutive Signaling by EGFRvIII R-HSA-5637810
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Infectious disease R-HSA-5663205
Nervous system development R-HSA-9675108
G alpha (q) signalling events R-HSA-416476
Generic Transcription Pathway R-HSA-212436
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Signal Transduction R-HSA-162582
L1CAM interactions R-HSA-373760
EGFR downregulation R-HSA-182971
Extra-nuclear estrogen signaling R-HSA-9009391
PI3K events in ERBB2 signaling R-HSA-1963642
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by EGFRvIII in Cancer R-HSA-5637812
Disease R-HSA-1643685
SHC1 events in EGFR signaling R-HSA-180336
Signaling by GPCR R-HSA-372790
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by PTK6 R-HSA-8848021
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
GRB2 events in ERBB2 signaling R-HSA-1963640
Clathrin-mediated endocytosis R-HSA-8856828
GAB1 signalosome R-HSA-180292
Downregulation of ERBB2 signaling R-HSA-8863795
PLCG1 events in ERBB2 signaling R-HSA-1251932
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by EGFR R-HSA-177929
GPCR downstream signalling R-HSA-388396
EGFR Transactivation by Gastrin R-HSA-2179392
PIP3 activates AKT signaling R-HSA-1257604
Gene expression (Transcription) R-HSA-74160
Axon guidance R-HSA-422475
Signal transduction by L1 R-HSA-445144
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
HCMV Early Events R-HSA-9609690
Signaling by ERBB4 R-HSA-1236394
Negative regulation of the PI3K/AKT network R-HSA-199418
Downregulation of ERBB2 signaling R-HSA-8863795
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K events in ERBB2 signaling R-HSA-1963642
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by EGFR R-HSA-177929
PTK6 promotes HIF1A stabilization R-HSA-8857538
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Developmental Biology R-HSA-1266738
Infectious disease R-HSA-5663205
GAB1 signalosome R-HSA-180292
RNA Polymerase II Transcription R-HSA-73857
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by ERBB4 R-HSA-1236394
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by GPCR R-HSA-372790
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
GPCR downstream signalling R-HSA-388396
Signaling by EGFR in Cancer R-HSA-1643713
PIP3 activates AKT signaling R-HSA-1257604
Gene expression (Transcription) R-HSA-74160
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH3 R-HSA-9012852
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by ERBB2 in Cancer R-HSA-1227990
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal Transduction R-HSA-162582
Signaling by ERBB2 R-HSA-1227986
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Extra-nuclear estrogen signaling R-HSA-9009391
Generic Transcription Pathway R-HSA-212436
L1CAM interactions R-HSA-373760
Signaling by ERBB2 KD Mutants R-HSA-9664565
Nervous system development R-HSA-9675108
MAPK1/MAPK3 signaling R-HSA-5684996
EGFR downregulation R-HSA-182971
G alpha (q) signalling events R-HSA-416476
Signal transduction by L1 R-HSA-445144
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
GRB2 events in ERBB2 signaling R-HSA-1963640
Intracellular signaling by second messengers R-HSA-9006925
EGFR interacts with phospholipase C-gamma R-HSA-212718
RAF/MAP kinase cascade R-HSA-5673001
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PLCG1 events in ERBB2 signaling R-HSA-1251932
GRB2 events in EGFR signaling R-HSA-179812
EGFR Transactivation by Gastrin R-HSA-2179392
HCMV Early Events R-HSA-9609690
SHC1 events in EGFR signaling R-HSA-180336
Signaling by NOTCH R-HSA-157118
MAPK family signaling cascades R-HSA-5683057
Signaling by PTK6 R-HSA-8848021
Clathrin-mediated endocytosis R-HSA-8856828
Disease R-HSA-1643685
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Membrane Trafficking R-HSA-199991
Axon guidance R-HSA-422475
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Vesicle-mediated transport R-HSA-5653656
HCMV Infection R-HSA-9609646
ESR-mediated signaling R-HSA-8939211
Intracellular signaling by second messengers R-HSA-9006925
Nervous system development R-HSA-9675108
EGFR Transactivation by Gastrin R-HSA-2179392
PLCG1 events in ERBB2 signaling R-HSA-1251932
Signal transduction by L1 R-HSA-445144
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
GPCR downstream signalling R-HSA-388396
HCMV Infection R-HSA-9609646
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
MAPK1/MAPK3 signaling R-HSA-5684996
PIP3 activates AKT signaling R-HSA-1257604
Signaling by PTK6 R-HSA-8848021
EGFR interacts with phospholipase C-gamma R-HSA-212718
HCMV Early Events R-HSA-9609690
EGFR downregulation R-HSA-182971
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
PTK6 promotes HIF1A stabilization R-HSA-8857538
GRB2 events in EGFR signaling R-HSA-179812
MAPK family signaling cascades R-HSA-5683057
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
RNA Polymerase II Transcription R-HSA-73857
Clathrin-mediated endocytosis R-HSA-8856828
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by EGFR R-HSA-177929
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Nuclear Receptors R-HSA-9006931
Generic Transcription Pathway R-HSA-212436
SHC1 events in EGFR signaling R-HSA-180336
Vesicle-mediated transport R-HSA-5653656
Signaling by EGFR in Cancer R-HSA-1643713
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by NOTCH R-HSA-157118
PI3K/AKT Signaling in Cancer R-HSA-2219528
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 in Cancer R-HSA-1227990
ERBB2 Regulates Cell Motility R-HSA-6785631
ESR-mediated signaling R-HSA-8939211
L1CAM interactions R-HSA-373760
RAF/MAP kinase cascade R-HSA-5673001
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by NOTCH3 R-HSA-9012852
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
GAB1 signalosome R-HSA-180292
Signaling by GPCR R-HSA-372790
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by ERBB2 R-HSA-1227986
Signaling by ERBB2 KD Mutants R-HSA-9664565
Disease R-HSA-1643685
SHC1 events in ERBB2 signaling R-HSA-1250196
Gene expression (Transcription) R-HSA-74160
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Membrane Trafficking R-HSA-199991
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by EGFRvIII in Cancer R-HSA-5637812
Extra-nuclear estrogen signaling R-HSA-9009391
Constitutive Signaling by EGFRvIII R-HSA-5637810
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Infectious disease R-HSA-5663205
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by EGFR in Cancer R-HSA-1643713
Intracellular signaling by second messengers R-HSA-9006925
Downregulation of ERBB2 signaling R-HSA-8863795
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by NOTCH R-HSA-157118
EGFR downregulation R-HSA-182971
GRB2 events in ERBB2 signaling R-HSA-1963640
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by ERBB2 in Cancer R-HSA-1227990
Infectious disease R-HSA-5663205
Signaling by ERBB2 R-HSA-1227986
Generic Transcription Pathway R-HSA-212436
Clathrin-mediated endocytosis R-HSA-8856828
RNA Polymerase II Transcription R-HSA-73857
Signaling by ERBB4 R-HSA-1236394
PTK6 promotes HIF1A stabilization R-HSA-8857538
SHC1 events in ERBB2 signaling R-HSA-1250196
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
ERBB2 Regulates Cell Motility R-HSA-6785631
Gene expression (Transcription) R-HSA-74160
Vesicle-mediated transport R-HSA-5653656
Axon guidance R-HSA-422475
Signaling by PTK6 R-HSA-8848021
HCMV Infection R-HSA-9609646
MAPK family signaling cascades R-HSA-5683057
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
HCMV Early Events R-HSA-9609690
RAF/MAP kinase cascade R-HSA-5673001
EGFR interacts with phospholipase C-gamma R-HSA-212718
Membrane Trafficking R-HSA-199991
Constitutive Signaling by EGFRvIII R-HSA-5637810
PI3K events in ERBB2 signaling R-HSA-1963642
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
GAB1 signalosome R-HSA-180292
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signal transduction by L1 R-HSA-445144
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by GPCR R-HSA-372790
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
GPCR downstream signalling R-HSA-388396
Signaling by NOTCH3 R-HSA-9012852
Signal Transduction R-HSA-162582
EGFR Transactivation by Gastrin R-HSA-2179392
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
L1CAM interactions R-HSA-373760
Signaling by EGFR R-HSA-177929
G alpha (q) signalling events R-HSA-416476
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Negative regulation of the PI3K/AKT network R-HSA-199418
PLCG1 events in ERBB2 signaling R-HSA-1251932
PIP3 activates AKT signaling R-HSA-1257604
Nervous system development R-HSA-9675108
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
GRB2 events in EGFR signaling R-HSA-179812
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
ESR-mediated signaling R-HSA-8939211
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SHC1 events in EGFR signaling R-HSA-180336

Expression Atlas ENSG00000146648
LRG display in Ensembl gene LRG_304
NCBI gene (formerly Entrezgene) 1956
GeneCards 3236
HGNC Symbol HGNC:3236
MIM gene 131550
MIM morbid 616069
UniProtKB Gene Name Q504U8
WikiGene 1956
Gene: SYK
Ensembl ID : ENSG00000165025
Description: spleen associated tyrosine kinase
Gene Synonyms:
14 APIs:
203 Possible Orthologues:

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Infectious disease R-HSA-5663205
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
FCERI mediated MAPK activation R-HSA-2871796
Disease R-HSA-1643685
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Platelet activation, signaling and aggregation R-HSA-76002
Regulation of signaling by CBL R-HSA-912631
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
FCERI mediated Ca+2 mobilization R-HSA-2871809
FLT3 Signaling R-HSA-9607240
Dectin-2 family R-HSA-5621480
DAP12 signaling R-HSA-2424491
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
GPVI-mediated activation cascade R-HSA-114604
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Parasite infection R-HSA-9664407
CLEC7A (Dectin-1) signaling R-HSA-5607764
Leishmania phagocytosis R-HSA-9664417
SARS-CoV Infections R-HSA-9679506
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Interleukin-2 family signaling R-HSA-451927
C-type lectin receptors (CLRs) R-HSA-5621481
Interleukin-2 signaling R-HSA-9020558
Hemostasis R-HSA-109582
Signaling by CSF3 (G-CSF) R-HSA-9674555
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Platelet Aggregation (Plug Formation) R-HSA-76009
DAP12 interactions R-HSA-2172127
Leishmania infection R-HSA-9658195
Signal Transduction R-HSA-162582
FCGR activation R-HSA-2029481
Leishmania parasite growth and survival R-HSA-9664433
Integrin signaling R-HSA-354192
FCGR3A-mediated phagocytosis R-HSA-9664422
Potential therapeutics for SARS R-HSA-9679191
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Cytokine Signaling in Immune system R-HSA-1280215
FLT3 signaling through SRC family kinases R-HSA-9706374
Role of phospholipids in phagocytosis R-HSA-2029485
FCGR activation R-HSA-2029481
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Hemostasis R-HSA-109582
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Dectin-2 family R-HSA-5621480
Regulation of signaling by CBL R-HSA-912631
Signaling by Interleukins R-HSA-449147
Interleukin-2 family signaling R-HSA-451927
Cytokine Signaling in Immune system R-HSA-1280215
GPVI-mediated activation cascade R-HSA-114604
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
CLEC7A (Dectin-1) signaling R-HSA-5607764
FCERI mediated MAPK activation R-HSA-2871796
Potential therapeutics for SARS R-HSA-9679191
Role of phospholipids in phagocytosis R-HSA-2029485
Innate Immune System R-HSA-168249
Leishmania infection R-HSA-9658195
Leishmania phagocytosis R-HSA-9664417
FCERI mediated Ca+2 mobilization R-HSA-2871809
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
DAP12 interactions R-HSA-2172127
SARS-CoV Infections R-HSA-9679506
FLT3 signaling through SRC family kinases R-HSA-9706374
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Immune System R-HSA-168256
Adaptive Immune System R-HSA-1280218
FLT3 Signaling R-HSA-9607240
Platelet activation, signaling and aggregation R-HSA-76002
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Leishmania parasite growth and survival R-HSA-9664433
DAP12 signaling R-HSA-2424491
Infectious disease R-HSA-5663205
Integrin signaling R-HSA-354192
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-2 signaling R-HSA-9020558
Platelet Aggregation (Plug Formation) R-HSA-76009
Parasite infection R-HSA-9664407
FCGR3A-mediated phagocytosis R-HSA-9664422
Leishmania phagocytosis R-HSA-9664417
Platelet activation, signaling and aggregation R-HSA-76002
FCGR3A-mediated phagocytosis R-HSA-9664422
Regulation of signaling by CBL R-HSA-912631
Interleukin-2 signaling R-HSA-9020558
FLT3 Signaling R-HSA-9607240
Adaptive Immune System R-HSA-1280218
DAP12 interactions R-HSA-2172127
FCERI mediated Ca+2 mobilization R-HSA-2871809
Role of phospholipids in phagocytosis R-HSA-2029485
Signal Transduction R-HSA-162582
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
SARS-CoV Infections R-HSA-9679506
GPVI-mediated activation cascade R-HSA-114604
DAP12 signaling R-HSA-2424491
Leishmania infection R-HSA-9658195
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Dectin-2 family R-HSA-5621480
Innate Immune System R-HSA-168249
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Leishmania parasite growth and survival R-HSA-9664433
Potential therapeutics for SARS R-HSA-9679191
Platelet Aggregation (Plug Formation) R-HSA-76009
Cytokine Signaling in Immune system R-HSA-1280215
Infectious disease R-HSA-5663205
FCERI mediated MAPK activation R-HSA-2871796
C-type lectin receptors (CLRs) R-HSA-5621481
Integrin signaling R-HSA-354192
CLEC7A (Dectin-1) signaling R-HSA-5607764
Signaling by CSF3 (G-CSF) R-HSA-9674555
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Immune System R-HSA-168256
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Interleukin-2 family signaling R-HSA-451927
Disease R-HSA-1643685
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Parasite infection R-HSA-9664407
Signaling by Interleukins R-HSA-449147
Hemostasis R-HSA-109582
FLT3 signaling through SRC family kinases R-HSA-9706374
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FCGR activation R-HSA-2029481
Signal Transduction R-HSA-162582
Signaling by Interleukins R-HSA-449147
Interleukin-2 signaling R-HSA-9020558
Leishmania parasite growth and survival R-HSA-9664433
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Cytokine Signaling in Immune system R-HSA-1280215
FCERI mediated MAPK activation R-HSA-2871796
Innate Immune System R-HSA-168249
SARS-CoV Infections R-HSA-9679506
FLT3 Signaling R-HSA-9607240
FCGR activation R-HSA-2029481
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
FLT3 signaling through SRC family kinases R-HSA-9706374
C-type lectin receptors (CLRs) R-HSA-5621481
GPVI-mediated activation cascade R-HSA-114604
FCGR3A-mediated IL10 synthesis R-HSA-9664323
FCGR3A-mediated phagocytosis R-HSA-9664422
Integrin signaling R-HSA-354192
Platelet Aggregation (Plug Formation) R-HSA-76009
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Interleukin-2 family signaling R-HSA-451927
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
FCERI mediated Ca+2 mobilization R-HSA-2871809
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Potential therapeutics for SARS R-HSA-9679191
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Platelet activation, signaling and aggregation R-HSA-76002
CLEC7A (Dectin-1) signaling R-HSA-5607764
Regulation of signaling by CBL R-HSA-912631
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Dectin-2 family R-HSA-5621480
Hemostasis R-HSA-109582
Disease R-HSA-1643685
DAP12 interactions R-HSA-2172127
Leishmania phagocytosis R-HSA-9664417
DAP12 signaling R-HSA-2424491
Signaling by CSF3 (G-CSF) R-HSA-9674555
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Infectious disease R-HSA-5663205
Immune System R-HSA-168256
Role of phospholipids in phagocytosis R-HSA-2029485
Leishmania infection R-HSA-9658195
Parasite infection R-HSA-9664407
Adaptive Immune System R-HSA-1280218
Innate Immune System R-HSA-168249
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
FLT3 signaling through SRC family kinases R-HSA-9706374
Adaptive Immune System R-HSA-1280218
FCGR activation R-HSA-2029481
Disease R-HSA-1643685
Signaling by Interleukins R-HSA-449147
FCGR3A-mediated phagocytosis R-HSA-9664422
DAP12 signaling R-HSA-2424491
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
FCERI mediated Ca+2 mobilization R-HSA-2871809
Leishmania phagocytosis R-HSA-9664417
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FLT3 Signaling R-HSA-9607240
Interleukin-2 signaling R-HSA-9020558
Infectious disease R-HSA-5663205
Hemostasis R-HSA-109582
Parasite infection R-HSA-9664407
CLEC7A (Dectin-1) signaling R-HSA-5607764
Potential therapeutics for SARS R-HSA-9679191
Leishmania infection R-HSA-9658195
Platelet activation, signaling and aggregation R-HSA-76002
Regulation of signaling by CBL R-HSA-912631
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
FCERI mediated MAPK activation R-HSA-2871796
Signaling by CSF3 (G-CSF) R-HSA-9674555
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Role of phospholipids in phagocytosis R-HSA-2029485
C-type lectin receptors (CLRs) R-HSA-5621481
Cytokine Signaling in Immune system R-HSA-1280215
Dectin-2 family R-HSA-5621480
Leishmania parasite growth and survival R-HSA-9664433
Immune System R-HSA-168256
Platelet Aggregation (Plug Formation) R-HSA-76009
Signal Transduction R-HSA-162582
Integrin signaling R-HSA-354192
GPVI-mediated activation cascade R-HSA-114604
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Interleukin-2 family signaling R-HSA-451927
DAP12 interactions R-HSA-2172127
SARS-CoV Infections R-HSA-9679506
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by the B Cell Receptor (BCR) R-HSA-983705
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Role of phospholipids in phagocytosis R-HSA-2029485
FCERI mediated MAPK activation R-HSA-2871796
Infectious disease R-HSA-5663205
DAP12 signaling R-HSA-2424491
GPVI-mediated activation cascade R-HSA-114604
Platelet Aggregation (Plug Formation) R-HSA-76009
Interleukin-2 signaling R-HSA-9020558
CLEC7A (Dectin-1) signaling R-HSA-5607764
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Leishmania parasite growth and survival R-HSA-9664433
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Signaling by CSF3 (G-CSF) R-HSA-9674555
Innate Immune System R-HSA-168249
Hemostasis R-HSA-109582
SARS-CoV Infections R-HSA-9679506
Leishmania phagocytosis R-HSA-9664417
Potential therapeutics for SARS R-HSA-9679191
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Dectin-2 family R-HSA-5621480
DAP12 interactions R-HSA-2172127
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FCGR activation R-HSA-2029481
FLT3 signaling through SRC family kinases R-HSA-9706374
Adaptive Immune System R-HSA-1280218
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Disease R-HSA-1643685
Platelet activation, signaling and aggregation R-HSA-76002
C-type lectin receptors (CLRs) R-HSA-5621481
FCGR3A-mediated phagocytosis R-HSA-9664422
FCERI mediated Ca+2 mobilization R-HSA-2871809
Leishmania infection R-HSA-9658195
Interleukin-2 family signaling R-HSA-451927
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signal Transduction R-HSA-162582
FLT3 Signaling R-HSA-9607240
Parasite infection R-HSA-9664407
Regulation of signaling by CBL R-HSA-912631
Signaling by Interleukins R-HSA-449147
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Immune System R-HSA-168256
Integrin signaling R-HSA-354192
Signaling by Interleukins R-HSA-449147
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Integrin signaling R-HSA-354192
Signaling by CSF3 (G-CSF) R-HSA-9674555
Cytokine Signaling in Immune system R-HSA-1280215
Role of phospholipids in phagocytosis R-HSA-2029485
DAP12 interactions R-HSA-2172127
Leishmania parasite growth and survival R-HSA-9664433
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
C-type lectin receptors (CLRs) R-HSA-5621481
Dectin-2 family R-HSA-5621480
Platelet Aggregation (Plug Formation) R-HSA-76009
Signal Transduction R-HSA-162582
FLT3 Signaling R-HSA-9607240
Parasite infection R-HSA-9664407
FCGR3A-mediated phagocytosis R-HSA-9664422
FCERI mediated MAPK activation R-HSA-2871796
Innate Immune System R-HSA-168249
GPVI-mediated activation cascade R-HSA-114604
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Infectious disease R-HSA-5663205
Hemostasis R-HSA-109582
SARS-CoV Infections R-HSA-9679506
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
DAP12 signaling R-HSA-2424491
FCGR activation R-HSA-2029481
CLEC7A (Dectin-1) signaling R-HSA-5607764
Leishmania phagocytosis R-HSA-9664417
FCERI mediated Ca+2 mobilization R-HSA-2871809
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Adaptive Immune System R-HSA-1280218
FLT3 signaling through SRC family kinases R-HSA-9706374
Platelet activation, signaling and aggregation R-HSA-76002
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Interleukin-2 family signaling R-HSA-451927
Potential therapeutics for SARS R-HSA-9679191
Interleukin-2 signaling R-HSA-9020558
Regulation of signaling by CBL R-HSA-912631
Immune System R-HSA-168256
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Regulation of signaling by CBL R-HSA-912631
Hemostasis R-HSA-109582
FCGR3A-mediated phagocytosis R-HSA-9664422
Dectin-2 family R-HSA-5621480
DAP12 signaling R-HSA-2424491
Infectious disease R-HSA-5663205
Potential therapeutics for SARS R-HSA-9679191
Platelet activation, signaling and aggregation R-HSA-76002
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Immune System R-HSA-168256
CLEC7A (Dectin-1) signaling R-HSA-5607764
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
FLT3 Signaling R-HSA-9607240
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Interleukin-2 signaling R-HSA-9020558
FCERI mediated Ca+2 mobilization R-HSA-2871809
Leishmania phagocytosis R-HSA-9664417
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Interleukin-2 family signaling R-HSA-451927
Innate Immune System R-HSA-168249
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Signaling by CSF3 (G-CSF) R-HSA-9674555
SARS-CoV Infections R-HSA-9679506
GPVI-mediated activation cascade R-HSA-114604
Signaling by Interleukins R-HSA-449147
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FCGR activation R-HSA-2029481
Platelet Aggregation (Plug Formation) R-HSA-76009
FCERI mediated MAPK activation R-HSA-2871796
DAP12 interactions R-HSA-2172127
Leishmania parasite growth and survival R-HSA-9664433
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
C-type lectin receptors (CLRs) R-HSA-5621481
Integrin signaling R-HSA-354192
Signal Transduction R-HSA-162582
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Role of phospholipids in phagocytosis R-HSA-2029485
Parasite infection R-HSA-9664407
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
FLT3 signaling through SRC family kinases R-HSA-9706374
Adaptive Immune System R-HSA-1280218
Cytokine Signaling in Immune system R-HSA-1280215
Leishmania parasite growth and survival R-HSA-9664433
Interleukin-2 family signaling R-HSA-451927
FCGR3A-mediated IL10 synthesis R-HSA-9664323
DAP12 interactions R-HSA-2172127
Disease R-HSA-1643685
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FLT3 signaling through SRC family kinases R-HSA-9706374
Signal Transduction R-HSA-162582
Leishmania infection R-HSA-9658195
SARS-CoV Infections R-HSA-9679506
Interleukin-2 signaling R-HSA-9020558
Platelet Aggregation (Plug Formation) R-HSA-76009
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Platelet activation, signaling and aggregation R-HSA-76002
Adaptive Immune System R-HSA-1280218
Signaling by Interleukins R-HSA-449147
Parasite infection R-HSA-9664407
CLEC7A (Dectin-1) signaling R-HSA-5607764
Integrin signaling R-HSA-354192
FCERI mediated Ca+2 mobilization R-HSA-2871809
FCERI mediated MAPK activation R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
DAP12 signaling R-HSA-2424491
Potential therapeutics for SARS R-HSA-9679191
C-type lectin receptors (CLRs) R-HSA-5621481
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Leishmania phagocytosis R-HSA-9664417
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Infectious disease R-HSA-5663205
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Immune System R-HSA-168256
Signaling by CSF3 (G-CSF) R-HSA-9674555
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Cytokine Signaling in Immune system R-HSA-1280215
Hemostasis R-HSA-109582
Role of phospholipids in phagocytosis R-HSA-2029485
Regulation of signaling by CBL R-HSA-912631
Dectin-2 family R-HSA-5621480
GPVI-mediated activation cascade R-HSA-114604
FLT3 Signaling R-HSA-9607240
FCGR activation R-HSA-2029481
FCGR3A-mediated phagocytosis R-HSA-9664422
Innate Immune System R-HSA-168249
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Signaling by CSF3 (G-CSF) R-HSA-9674555
Leishmania parasite growth and survival R-HSA-9664433
FLT3 signaling through SRC family kinases R-HSA-9706374
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Integrin signaling R-HSA-354192
Role of phospholipids in phagocytosis R-HSA-2029485
SARS-CoV Infections R-HSA-9679506
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
DAP12 signaling R-HSA-2424491
Innate Immune System R-HSA-168249
DAP12 interactions R-HSA-2172127
Regulation of signaling by CBL R-HSA-912631
Interleukin-2 family signaling R-HSA-451927
Leishmania infection R-HSA-9658195
Platelet activation, signaling and aggregation R-HSA-76002
Infectious disease R-HSA-5663205
Signaling by Interleukins R-HSA-449147
FCGR3A-mediated phagocytosis R-HSA-9664422
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Hemostasis R-HSA-109582
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
FCERI mediated Ca+2 mobilization R-HSA-2871809
Leishmania phagocytosis R-HSA-9664417
FCERI mediated MAPK activation R-HSA-2871796
Interleukin-2 signaling R-HSA-9020558
Signal Transduction R-HSA-162582
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
CLEC7A (Dectin-1) signaling R-HSA-5607764
FCGR activation R-HSA-2029481
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Cytokine Signaling in Immune system R-HSA-1280215
Disease R-HSA-1643685
Immune System R-HSA-168256
FLT3 Signaling R-HSA-9607240
Platelet Aggregation (Plug Formation) R-HSA-76009
GPVI-mediated activation cascade R-HSA-114604
FCGR3A-mediated IL10 synthesis R-HSA-9664323
C-type lectin receptors (CLRs) R-HSA-5621481
Dectin-2 family R-HSA-5621480
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Potential therapeutics for SARS R-HSA-9679191
Adaptive Immune System R-HSA-1280218
Parasite infection R-HSA-9664407

Expression Atlas ENSG00000165025
NCBI gene (formerly Entrezgene) 6850
GeneCards 11491
HGNC Symbol HGNC:11491
MIM gene 600085
MIM morbid 619381
UniProtKB Gene Name P43405
WikiGene 6850
Gene: LYN
Ensembl ID : ENSG00000254087
Description: LYN proto-oncogene, Src family tyrosine kinase
Gene Synonyms: JTK8
4 APIs:
197 Possible Orthologues:

Innate Immune System R-HSA-168249
Growth hormone receptor signaling R-HSA-982772
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Axon guidance R-HSA-422475
Adaptive Immune System R-HSA-1280218
CD22 mediated BCR regulation R-HSA-5690714
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Infectious disease R-HSA-5663205
Signaling by Erythropoietin R-HSA-9006335
Signaling by Interleukins R-HSA-449147
Cyclin D associated events in G1 R-HSA-69231
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Signaling by SCF-KIT R-HSA-1433557
Leishmania infection R-HSA-9658195
EPHB-mediated forward signaling R-HSA-3928662
Cell Cycle R-HSA-1640170
Leishmania parasite growth and survival R-HSA-9664433
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Regulation of signaling by CBL R-HSA-912631
Hemostasis R-HSA-109582
G1 Phase R-HSA-69236
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
CD209 (DC-SIGN) signaling R-HSA-5621575
Regulation of KIT signaling R-HSA-1433559
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Dectin-2 family R-HSA-5621480
CTLA4 inhibitory signaling R-HSA-389513
Parasite infection R-HSA-9664407
Erythropoietin activates STAT5 R-HSA-9027283
Cell Cycle, Mitotic R-HSA-69278
Signaling by CSF3 (G-CSF) R-HSA-9674555
EPHA-mediated growth cone collapse R-HSA-3928663
FCERI mediated Ca+2 mobilization R-HSA-2871809
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Leishmania phagocytosis R-HSA-9664417
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
FCGR3A-mediated phagocytosis R-HSA-9664422
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Platelet activation, signaling and aggregation R-HSA-76002
EPH-Ephrin signaling R-HSA-2682334
Disease R-HSA-1643685
Signaling by KIT in disease R-HSA-9669938
GPVI-mediated activation cascade R-HSA-114604
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Mitotic G1 phase and G1/S transition R-HSA-453279
FCERI mediated MAPK activation R-HSA-2871796
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Erythropoietin activates RAS R-HSA-9027284
PECAM1 interactions R-HSA-210990
Nervous system development R-HSA-9675108
Developmental Biology R-HSA-1266738
FCERI mediated NF-kB activation R-HSA-2871837
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Costimulation by the CD28 family R-HSA-388841
C-type lectin receptors (CLRs) R-HSA-5621481
FCGR activation R-HSA-2029481
Cell surface interactions at the vascular wall R-HSA-202733
Signal Transduction R-HSA-162582
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Platelet Adhesion to exposed collagen R-HSA-75892
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
CD28 co-stimulation R-HSA-389356
Immune System R-HSA-168256
CD28 co-stimulation R-HSA-389356
FCGR activation R-HSA-2029481
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Leishmania infection R-HSA-9658195
Dectin-2 family R-HSA-5621480
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPHB-mediated forward signaling R-HSA-3928662
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Hemostasis R-HSA-109582
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cytokine Signaling in Immune system R-HSA-1280215
FCERI mediated MAPK activation R-HSA-2871796
Regulation of signaling by CBL R-HSA-912631
Adaptive Immune System R-HSA-1280218
Signaling by CSF3 (G-CSF) R-HSA-9674555
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
G1 Phase R-HSA-69236
Erythropoietin activates RAS R-HSA-9027284
Signaling by Interleukins R-HSA-449147
Developmental Biology R-HSA-1266738
Cell Cycle R-HSA-1640170
CD209 (DC-SIGN) signaling R-HSA-5621575
Erythropoietin activates STAT5 R-HSA-9027283
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
GPVI-mediated activation cascade R-HSA-114604
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Platelet Adhesion to exposed collagen R-HSA-75892
Signaling by Erythropoietin R-HSA-9006335
EPHA-mediated growth cone collapse R-HSA-3928663
Platelet activation, signaling and aggregation R-HSA-76002
EPH-Ephrin signaling R-HSA-2682334
Mitotic G1 phase and G1/S transition R-HSA-453279
Infectious disease R-HSA-5663205
CD22 mediated BCR regulation R-HSA-5690714
Axon guidance R-HSA-422475
Costimulation by the CD28 family R-HSA-388841
FCGR3A-mediated phagocytosis R-HSA-9664422
Disease R-HSA-1643685
PECAM1 interactions R-HSA-210990
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
FCERI mediated NF-kB activation R-HSA-2871837
Regulation of KIT signaling R-HSA-1433559
Leishmania phagocytosis R-HSA-9664417
Signaling by KIT in disease R-HSA-9669938
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
FCERI mediated Ca+2 mobilization R-HSA-2871809
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Cyclin D associated events in G1 R-HSA-69231
Signaling by SCF-KIT R-HSA-1433557
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Leishmania parasite growth and survival R-HSA-9664433
Growth hormone receptor signaling R-HSA-982772
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
C-type lectin receptors (CLRs) R-HSA-5621481
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Parasite infection R-HSA-9664407
Cell surface interactions at the vascular wall R-HSA-202733
Nervous system development R-HSA-9675108
CTLA4 inhibitory signaling R-HSA-389513
Cell Cycle, Mitotic R-HSA-69278
Cyclin D associated events in G1 R-HSA-69231
Signaling by Interleukins R-HSA-449147
FCERI mediated Ca+2 mobilization R-HSA-2871809
Parasite infection R-HSA-9664407
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Nervous system development R-HSA-9675108
FCGR3A-mediated phagocytosis R-HSA-9664422
C-type lectin receptors (CLRs) R-HSA-5621481
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
FCERI mediated NF-kB activation R-HSA-2871837
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signal Transduction R-HSA-162582
Erythropoietin activates RAS R-HSA-9027284
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Platelet Adhesion to exposed collagen R-HSA-75892
EPHA-mediated growth cone collapse R-HSA-3928663
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
CTLA4 inhibitory signaling R-HSA-389513
Signaling by SCF-KIT R-HSA-1433557
Growth hormone receptor signaling R-HSA-982772
FCERI mediated MAPK activation R-HSA-2871796
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Leishmania parasite growth and survival R-HSA-9664433
Hemostasis R-HSA-109582
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Regulation of signaling by CBL R-HSA-912631
Disease R-HSA-1643685
Dectin-2 family R-HSA-5621480
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Platelet activation, signaling and aggregation R-HSA-76002
Immune System R-HSA-168256
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Axon guidance R-HSA-422475
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Leishmania infection R-HSA-9658195
CD22 mediated BCR regulation R-HSA-5690714
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Signaling by Erythropoietin R-HSA-9006335
Developmental Biology R-HSA-1266738
CD28 co-stimulation R-HSA-389356
Adaptive Immune System R-HSA-1280218
Erythropoietin activates STAT5 R-HSA-9027283
EPHB-mediated forward signaling R-HSA-3928662
Regulation of KIT signaling R-HSA-1433559
GPVI-mediated activation cascade R-HSA-114604
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Costimulation by the CD28 family R-HSA-388841
Cytokine Signaling in Immune system R-HSA-1280215
Cell Cycle, Mitotic R-HSA-69278
G1 Phase R-HSA-69236
CD209 (DC-SIGN) signaling R-HSA-5621575
Mitotic G1 phase and G1/S transition R-HSA-453279
Infectious disease R-HSA-5663205
Cell Cycle R-HSA-1640170
Leishmania phagocytosis R-HSA-9664417
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by KIT in disease R-HSA-9669938
FCGR activation R-HSA-2029481
Innate Immune System R-HSA-168249
PECAM1 interactions R-HSA-210990
EPH-Ephrin signaling R-HSA-2682334
Signaling by CSF3 (G-CSF) R-HSA-9674555
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Leishmania phagocytosis R-HSA-9664417
Signaling by KIT in disease R-HSA-9669938
Costimulation by the CD28 family R-HSA-388841
Platelet activation, signaling and aggregation R-HSA-76002
EPHB-mediated forward signaling R-HSA-3928662
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Signal Transduction R-HSA-162582
Cyclin D associated events in G1 R-HSA-69231
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Parasite infection R-HSA-9664407
Innate Immune System R-HSA-168249
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Signaling by SCF-KIT R-HSA-1433557
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
GPVI-mediated activation cascade R-HSA-114604
Leishmania infection R-HSA-9658195
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Cell Cycle R-HSA-1640170
Erythropoietin activates RAS R-HSA-9027284
Dectin-2 family R-HSA-5621480
Growth hormone receptor signaling R-HSA-982772
Regulation of signaling by CBL R-HSA-912631
Erythropoietin activates STAT5 R-HSA-9027283
Mitotic G1 phase and G1/S transition R-HSA-453279
Developmental Biology R-HSA-1266738
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Regulation of KIT signaling R-HSA-1433559
CD22 mediated BCR regulation R-HSA-5690714
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Nervous system development R-HSA-9675108
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cell Cycle, Mitotic R-HSA-69278
CD28 co-stimulation R-HSA-389356
Signaling by CSF3 (G-CSF) R-HSA-9674555
FCGR3A-mediated phagocytosis R-HSA-9664422
Axon guidance R-HSA-422475
Infectious disease R-HSA-5663205
Leishmania parasite growth and survival R-HSA-9664433
FCERI mediated MAPK activation R-HSA-2871796
FCERI mediated Ca+2 mobilization R-HSA-2871809
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
FCGR activation R-HSA-2029481
Signaling by Interleukins R-HSA-449147
CTLA4 inhibitory signaling R-HSA-389513
Platelet Adhesion to exposed collagen R-HSA-75892
CD209 (DC-SIGN) signaling R-HSA-5621575
Cytokine Signaling in Immune system R-HSA-1280215
EPH-Ephrin signaling R-HSA-2682334
EPHA-mediated growth cone collapse R-HSA-3928663
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Disease R-HSA-1643685
FCERI mediated NF-kB activation R-HSA-2871837
G1 Phase R-HSA-69236
Adaptive Immune System R-HSA-1280218
Signaling by Erythropoietin R-HSA-9006335
PECAM1 interactions R-HSA-210990
Cell surface interactions at the vascular wall R-HSA-202733
Immune System R-HSA-168256
Hemostasis R-HSA-109582
C-type lectin receptors (CLRs) R-HSA-5621481
Cell Cycle, Mitotic R-HSA-69278
Signaling by CSF3 (G-CSF) R-HSA-9674555
Parasite infection R-HSA-9664407
G1 Phase R-HSA-69236
Signaling by the B Cell Receptor (BCR) R-HSA-983705
EPH-Ephrin signaling R-HSA-2682334
Mitotic G1 phase and G1/S transition R-HSA-453279
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
PECAM1 interactions R-HSA-210990
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Nervous system development R-HSA-9675108
Immune System R-HSA-168256
Developmental Biology R-HSA-1266738
Hemostasis R-HSA-109582
Signaling by SCF-KIT R-HSA-1433557
Erythropoietin activates STAT5 R-HSA-9027283
Infectious disease R-HSA-5663205
Axon guidance R-HSA-422475
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
FCERI mediated Ca+2 mobilization R-HSA-2871809
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Growth hormone receptor signaling R-HSA-982772
CD209 (DC-SIGN) signaling R-HSA-5621575
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Signal Transduction R-HSA-162582
Regulation of signaling by CBL R-HSA-912631
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
CD22 mediated BCR regulation R-HSA-5690714
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
CD28 co-stimulation R-HSA-389356
Leishmania infection R-HSA-9658195
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
FCERI mediated NF-kB activation R-HSA-2871837
CTLA4 inhibitory signaling R-HSA-389513
GPVI-mediated activation cascade R-HSA-114604
Platelet activation, signaling and aggregation R-HSA-76002
Regulation of KIT signaling R-HSA-1433559
Disease R-HSA-1643685
Cytokine Signaling in Immune system R-HSA-1280215
Platelet Adhesion to exposed collagen R-HSA-75892
Cell surface interactions at the vascular wall R-HSA-202733
FCERI mediated MAPK activation R-HSA-2871796
Adaptive Immune System R-HSA-1280218
Erythropoietin activates RAS R-HSA-9027284
FCGR activation R-HSA-2029481
Signaling by KIT in disease R-HSA-9669938
Cyclin D associated events in G1 R-HSA-69231
Innate Immune System R-HSA-168249
Dectin-2 family R-HSA-5621480
Leishmania phagocytosis R-HSA-9664417
Signaling by Interleukins R-HSA-449147
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Erythropoietin R-HSA-9006335
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FCGR3A-mediated phagocytosis R-HSA-9664422
EPHA-mediated growth cone collapse R-HSA-3928663
Cell Cycle R-HSA-1640170
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Costimulation by the CD28 family R-HSA-388841
Leishmania parasite growth and survival R-HSA-9664433
EPHB-mediated forward signaling R-HSA-3928662
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Nervous system development R-HSA-9675108
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signaling by Interleukins R-HSA-449147
FCGR3A-mediated phagocytosis R-HSA-9664422
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Cytokine Signaling in Immune system R-HSA-1280215
Infectious disease R-HSA-5663205
FCERI mediated MAPK activation R-HSA-2871796
Cell Cycle R-HSA-1640170
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
FCGR activation R-HSA-2029481
FCERI mediated Ca+2 mobilization R-HSA-2871809
Platelet activation, signaling and aggregation R-HSA-76002
Dectin-2 family R-HSA-5621480
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
CD209 (DC-SIGN) signaling R-HSA-5621575
G1 Phase R-HSA-69236
EPHA-mediated growth cone collapse R-HSA-3928663
Erythropoietin activates RAS R-HSA-9027284
Growth hormone receptor signaling R-HSA-982772
Disease R-HSA-1643685
Immune System R-HSA-168256
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
GPVI-mediated activation cascade R-HSA-114604
CD22 mediated BCR regulation R-HSA-5690714
Cell surface interactions at the vascular wall R-HSA-202733
Hemostasis R-HSA-109582
Mitotic G1 phase and G1/S transition R-HSA-453279
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
CTLA4 inhibitory signaling R-HSA-389513
Regulation of KIT signaling R-HSA-1433559
EPH-ephrin mediated repulsion of cells R-HSA-3928665
FCERI mediated NF-kB activation R-HSA-2871837
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of signaling by CBL R-HSA-912631
Adaptive Immune System R-HSA-1280218
Platelet Adhesion to exposed collagen R-HSA-75892
Leishmania phagocytosis R-HSA-9664417
Leishmania infection R-HSA-9658195
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Signaling by KIT in disease R-HSA-9669938
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Erythropoietin activates STAT5 R-HSA-9027283
Cell Cycle, Mitotic R-HSA-69278
Innate Immune System R-HSA-168249
Leishmania parasite growth and survival R-HSA-9664433
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Signaling by CSF3 (G-CSF) R-HSA-9674555
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
C-type lectin receptors (CLRs) R-HSA-5621481
Cyclin D associated events in G1 R-HSA-69231
Signaling by SCF-KIT R-HSA-1433557
PECAM1 interactions R-HSA-210990
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by Erythropoietin R-HSA-9006335
Parasite infection R-HSA-9664407
Costimulation by the CD28 family R-HSA-388841
EPHB-mediated forward signaling R-HSA-3928662
CD28 co-stimulation R-HSA-389356
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Leishmania infection R-HSA-9658195
Parasite infection R-HSA-9664407
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Axon guidance R-HSA-422475
Hemostasis R-HSA-109582
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
FCGR activation R-HSA-2029481
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Signaling by Interleukins R-HSA-449147
FCERI mediated Ca+2 mobilization R-HSA-2871809
Signaling by KIT in disease R-HSA-9669938
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by the B Cell Receptor (BCR) R-HSA-983705
EPHB-mediated forward signaling R-HSA-3928662
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
GPVI-mediated activation cascade R-HSA-114604
C-type lectin receptors (CLRs) R-HSA-5621481
CD209 (DC-SIGN) signaling R-HSA-5621575
Regulation of KIT signaling R-HSA-1433559
CD22 mediated BCR regulation R-HSA-5690714
EPHA-mediated growth cone collapse R-HSA-3928663
Signaling by CSF3 (G-CSF) R-HSA-9674555
Cytokine Signaling in Immune system R-HSA-1280215
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
FCERI mediated NF-kB activation R-HSA-2871837
Erythropoietin activates STAT5 R-HSA-9027283
G1 Phase R-HSA-69236
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Costimulation by the CD28 family R-HSA-388841
Mitotic G1 phase and G1/S transition R-HSA-453279
Growth hormone receptor signaling R-HSA-982772
EPH-ephrin mediated repulsion of cells R-HSA-3928665
CTLA4 inhibitory signaling R-HSA-389513
Infectious disease R-HSA-5663205
FCGR3A-mediated phagocytosis R-HSA-9664422
Cell surface interactions at the vascular wall R-HSA-202733
Nervous system development R-HSA-9675108
Signaling by Erythropoietin R-HSA-9006335
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Developmental Biology R-HSA-1266738
Signaling by SCF-KIT R-HSA-1433557
Leishmania parasite growth and survival R-HSA-9664433
Leishmania phagocytosis R-HSA-9664417
Innate Immune System R-HSA-168249
EPH-Ephrin signaling R-HSA-2682334
Cell Cycle R-HSA-1640170
Immune System R-HSA-168256
Regulation of signaling by CBL R-HSA-912631
Cell Cycle, Mitotic R-HSA-69278
Signal Transduction R-HSA-162582
Platelet Adhesion to exposed collagen R-HSA-75892
PECAM1 interactions R-HSA-210990
Platelet activation, signaling and aggregation R-HSA-76002
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
CD28 co-stimulation R-HSA-389356
Cyclin D associated events in G1 R-HSA-69231
FCERI mediated MAPK activation R-HSA-2871796
Adaptive Immune System R-HSA-1280218
Dectin-2 family R-HSA-5621480
Erythropoietin activates RAS R-HSA-9027284
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Signal Transduction R-HSA-162582
Immune System R-HSA-168256
Nervous system development R-HSA-9675108
C-type lectin receptors (CLRs) R-HSA-5621481
G1 Phase R-HSA-69236
CTLA4 inhibitory signaling R-HSA-389513
EPHB-mediated forward signaling R-HSA-3928662
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
FCERI mediated MAPK activation R-HSA-2871796
Cyclin D associated events in G1 R-HSA-69231
EPH-Ephrin signaling R-HSA-2682334
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Hemostasis R-HSA-109582
Axon guidance R-HSA-422475
Leishmania phagocytosis R-HSA-9664417
Cell Cycle, Mitotic R-HSA-69278
FCGR activation R-HSA-2029481
Regulation of signaling by CBL R-HSA-912631
Regulation of KIT signaling R-HSA-1433559
FCERI mediated NF-kB activation R-HSA-2871837
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Innate Immune System R-HSA-168249
Cell Cycle R-HSA-1640170
CD209 (DC-SIGN) signaling R-HSA-5621575
Costimulation by the CD28 family R-HSA-388841
Signaling by Erythropoietin R-HSA-9006335
Adaptive Immune System R-HSA-1280218
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
GPVI-mediated activation cascade R-HSA-114604
Developmental Biology R-HSA-1266738
Platelet activation, signaling and aggregation R-HSA-76002
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Erythropoietin activates RAS R-HSA-9027284
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Leishmania infection R-HSA-9658195
Signaling by KIT in disease R-HSA-9669938
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Cell surface interactions at the vascular wall R-HSA-202733
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Infectious disease R-HSA-5663205
EPHA-mediated growth cone collapse R-HSA-3928663
FCERI mediated Ca+2 mobilization R-HSA-2871809
Parasite infection R-HSA-9664407
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Erythropoietin activates STAT5 R-HSA-9027283
CD28 co-stimulation R-HSA-389356
Signaling by CSF3 (G-CSF) R-HSA-9674555
Cytokine Signaling in Immune system R-HSA-1280215
CD22 mediated BCR regulation R-HSA-5690714
FCGR3A-mediated phagocytosis R-HSA-9664422
Disease R-HSA-1643685
Dectin-2 family R-HSA-5621480
PECAM1 interactions R-HSA-210990
Signaling by Interleukins R-HSA-449147
Mitotic G1 phase and G1/S transition R-HSA-453279
Platelet Adhesion to exposed collagen R-HSA-75892
Leishmania parasite growth and survival R-HSA-9664433
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Signaling by SCF-KIT R-HSA-1433557
Growth hormone receptor signaling R-HSA-982772
Signaling by Erythropoietin R-HSA-9006335
Platelet Adhesion to exposed collagen R-HSA-75892
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Innate Immune System R-HSA-168249
C-type lectin receptors (CLRs) R-HSA-5621481
Leishmania phagocytosis R-HSA-9664417
FCGR3A-mediated phagocytosis R-HSA-9664422
CD28 co-stimulation R-HSA-389356
FCGR activation R-HSA-2029481
PECAM1 interactions R-HSA-210990
Cell Cycle, Mitotic R-HSA-69278
Nervous system development R-HSA-9675108
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Interleukins R-HSA-449147
Infectious disease R-HSA-5663205
Platelet activation, signaling and aggregation R-HSA-76002
CD22 mediated BCR regulation R-HSA-5690714
Signal Transduction R-HSA-162582
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Growth hormone receptor signaling R-HSA-982772
Leishmania infection R-HSA-9658195
Developmental Biology R-HSA-1266738
GPVI-mediated activation cascade R-HSA-114604
EPH-Ephrin signaling R-HSA-2682334
Disease R-HSA-1643685
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Erythropoietin activates RAS R-HSA-9027284
CTLA4 inhibitory signaling R-HSA-389513
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
FCERI mediated MAPK activation R-HSA-2871796
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by KIT in disease R-HSA-9669938
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Cytokine Signaling in Immune system R-HSA-1280215
FCERI mediated Ca+2 mobilization R-HSA-2871809
FCGR3A-mediated IL10 synthesis R-HSA-9664323
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Cell Cycle R-HSA-1640170
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by SCF-KIT R-HSA-1433557
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
EPHA-mediated growth cone collapse R-HSA-3928663
EPHB-mediated forward signaling R-HSA-3928662
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
G1 Phase R-HSA-69236
Leishmania parasite growth and survival R-HSA-9664433
Immune System R-HSA-168256
Costimulation by the CD28 family R-HSA-388841
Regulation of signaling by CBL R-HSA-912631
Mitotic G1 phase and G1/S transition R-HSA-453279
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Axon guidance R-HSA-422475
Cyclin D associated events in G1 R-HSA-69231
Cell surface interactions at the vascular wall R-HSA-202733
Regulation of KIT signaling R-HSA-1433559
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Dectin-2 family R-HSA-5621480
FCERI mediated NF-kB activation R-HSA-2871837
Adaptive Immune System R-HSA-1280218
Signaling by CSF3 (G-CSF) R-HSA-9674555
Parasite infection R-HSA-9664407
Hemostasis R-HSA-109582
Erythropoietin activates STAT5 R-HSA-9027283
Hemostasis R-HSA-109582
Growth hormone receptor signaling R-HSA-982772
Signaling by KIT in disease R-HSA-9669938
Cell Cycle R-HSA-1640170
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Platelet Adhesion to exposed collagen R-HSA-75892
Signaling by SCF-KIT R-HSA-1433557
Parasite infection R-HSA-9664407
Leishmania phagocytosis R-HSA-9664417
Disease R-HSA-1643685
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983695
Dectin-2 family R-HSA-5621480
CD28 co-stimulation R-HSA-389356
Erythropoietin activates STAT5 R-HSA-9027283
G1 Phase R-HSA-69236
Regulation of signaling by CBL R-HSA-912631
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Costimulation by the CD28 family R-HSA-388841
Erythropoietin activates RAS R-HSA-9027284
Cytokine Signaling in Immune system R-HSA-1280215
FCGR3A-mediated phagocytosis R-HSA-9664422
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
EPHB-mediated forward signaling R-HSA-3928662
Nervous system development R-HSA-9675108
Mitotic G1 phase and G1/S transition R-HSA-453279
FCERI mediated Ca+2 mobilization R-HSA-2871809
CTLA4 inhibitory signaling R-HSA-389513
CD209 (DC-SIGN) signaling R-HSA-5621575
GPVI-mediated activation cascade R-HSA-114604
Leishmania parasite growth and survival R-HSA-9664433
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Adaptive Immune System R-HSA-1280218
EPHA-mediated growth cone collapse R-HSA-3928663
Infectious disease R-HSA-5663205
Anti-inflammatory response favouring Leishmania parasite infection R-HSA-9662851
C-type lectin receptors (CLRs) R-HSA-5621481
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Regulation of KIT signaling R-HSA-1433559
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Immune System R-HSA-168256
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
FCERI mediated MAPK activation R-HSA-2871796
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Innate Immune System R-HSA-168249
Leishmania infection R-HSA-9658195
CD22 mediated BCR regulation R-HSA-5690714
Signal Transduction R-HSA-162582
Platelet activation, signaling and aggregation R-HSA-76002
Axon guidance R-HSA-422475
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by CSF3 (G-CSF) R-HSA-9674555
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Developmental Biology R-HSA-1266738
FCGR activation R-HSA-2029481
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cyclin D associated events in G1 R-HSA-69231
FCGR3A-mediated IL10 synthesis R-HSA-9664323
EPH-Ephrin signaling R-HSA-2682334
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Cell Cycle, Mitotic R-HSA-69278
Signaling by Erythropoietin R-HSA-9006335
PECAM1 interactions R-HSA-210990
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Interleukins R-HSA-449147
FCERI mediated NF-kB activation R-HSA-2871837

Expression Atlas ENSG00000254087
NCBI gene (formerly Entrezgene) 4067
GeneCards 6735
HGNC Symbol HGNC:6735
MIM gene 165120
UniProtKB Gene Name P07948
WikiGene 4067
Gene: JAK1
Ensembl ID : ENSG00000162434
Description: Janus kinase 1
Gene Synonyms: JAK1A,JAK1B,JTK3
19 APIs:
238 Possible Orthologues:

Disease R-HSA-1643685
Interferon gamma signaling R-HSA-877300
ISG15 antiviral mechanism R-HSA-1169408
Interleukin-21 signaling R-HSA-9020958
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-2 signaling R-HSA-9020558
Interleukin-9 signaling R-HSA-8985947
SARS-CoV Infections R-HSA-9679506
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Regulation of IFNA/IFNB signaling R-HSA-912694
Other interleukin signaling R-HSA-449836
Immune System R-HSA-168256
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-2 family signaling R-HSA-451927
Interleukin-12 signaling R-HSA-9020591
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-35 Signalling R-HSA-8984722
MAPK3 (ERK1) activation R-HSA-110056
Signal Transduction R-HSA-162582
Interleukin-27 signaling R-HSA-9020956
Interleukin-7 signaling R-HSA-1266695
Interleukin-10 signaling R-HSA-6783783
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
MAPK family signaling cascades R-HSA-5683057
Infectious disease R-HSA-5663205
Interleukin-6 signaling R-HSA-1059683
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-15 signaling R-HSA-8983432
Regulation of IFNG signaling R-HSA-877312
Interleukin receptor SHC signaling R-HSA-912526
Potential therapeutics for SARS R-HSA-9679191
SARS-CoV-2 Infection R-HSA-9694516
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
SARS-CoV-2-host interactions R-HSA-9705683
Interferon Signaling R-HSA-913531
Interferon alpha/beta signaling R-HSA-909733
Signaling by Interleukins R-HSA-449147
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Interleukin-12 family signaling R-HSA-447115
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Interleukin-6 family signaling R-HSA-6783589
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-20 family signaling R-HSA-8854691
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-12 signaling R-HSA-9020591
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Regulation of IFNG signaling R-HSA-877312
Interferon gamma signaling R-HSA-877300
Disease R-HSA-1643685
Interleukin-7 signaling R-HSA-1266695
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
MAPK1 (ERK2) activation R-HSA-112411
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Other interleukin signaling R-HSA-449836
Immune System R-HSA-168256
ISG15 antiviral mechanism R-HSA-1169408
MAPK family signaling cascades R-HSA-5683057
SARS-CoV-2 Infection R-HSA-9694516
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-2 family signaling R-HSA-451927
Interleukin-6 signaling R-HSA-1059683
RAF-independent MAPK1/3 activation R-HSA-112409
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by Interleukins R-HSA-449147
Interleukin-21 signaling R-HSA-9020958
Interleukin-12 family signaling R-HSA-447115
Interferon Signaling R-HSA-913531
Interleukin-35 Signalling R-HSA-8984722
Interleukin-6 family signaling R-HSA-6783589
Interleukin-27 signaling R-HSA-9020956
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
SARS-CoV Infections R-HSA-9679506
Interleukin-9 signaling R-HSA-8985947
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interleukin-2 signaling R-HSA-9020558
MAPK3 (ERK1) activation R-HSA-110056
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin receptor SHC signaling R-HSA-912526
Signal Transduction R-HSA-162582
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-15 signaling R-HSA-8983432
Interleukin-10 signaling R-HSA-6783783
Infectious disease R-HSA-5663205
Potential therapeutics for SARS R-HSA-9679191
Interleukin-20 family signaling R-HSA-8854691
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interferon alpha/beta signaling R-HSA-909733
Interferon gamma signaling R-HSA-877300
Interleukin-10 signaling R-HSA-6783783
MAPK1/MAPK3 signaling R-HSA-5684996
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Potential therapeutics for SARS R-HSA-9679191
MAPK3 (ERK1) activation R-HSA-110056
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interferon Signaling R-HSA-913531
Interleukin-35 Signalling R-HSA-8984722
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signal Transduction R-HSA-162582
Regulation of IFNA/IFNB signaling R-HSA-912694
ISG15 antiviral mechanism R-HSA-1169408
Infectious disease R-HSA-5663205
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV-2-host interactions R-HSA-9705683
Interleukin-15 signaling R-HSA-8983432
Interferon alpha/beta signaling R-HSA-909733
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-7 signaling R-HSA-1266695
Signaling by Interleukins R-HSA-449147
Interleukin-12 signaling R-HSA-9020591
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by CSF3 (G-CSF) R-HSA-9674555
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-6 family signaling R-HSA-6783589
Interleukin-9 signaling R-HSA-8985947
Immune System R-HSA-168256
Interleukin-21 signaling R-HSA-9020958
Disease R-HSA-1643685
Interleukin-6 signaling R-HSA-1059683
Regulation of IFNG signaling R-HSA-877312
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
SARS-CoV Infections R-HSA-9679506
MAPK family signaling cascades R-HSA-5683057
Interleukin-20 family signaling R-HSA-8854691
Interleukin-12 family signaling R-HSA-447115
Interleukin-2 signaling R-HSA-9020558
Interleukin receptor SHC signaling R-HSA-912526
Interleukin-27 signaling R-HSA-9020956
Interleukin-2 family signaling R-HSA-451927
MAPK1 (ERK2) activation R-HSA-112411
Other interleukin signaling R-HSA-449836
Interleukin-35 Signalling R-HSA-8984722
Signaling by CSF3 (G-CSF) R-HSA-9674555
Immune System R-HSA-168256
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
ISG15 antiviral mechanism R-HSA-1169408
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-20 family signaling R-HSA-8854691
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-15 signaling R-HSA-8983432
Interleukin-6 family signaling R-HSA-6783589
Potential therapeutics for SARS R-HSA-9679191
Interleukin-21 signaling R-HSA-9020958
Regulation of IFNA/IFNB signaling R-HSA-912694
Infectious disease R-HSA-5663205
RAF-independent MAPK1/3 activation R-HSA-112409
SARS-CoV Infections R-HSA-9679506
Interleukin-27 signaling R-HSA-9020956
Interleukin-12 family signaling R-HSA-447115
Interleukin-6 signaling R-HSA-1059683
Signal Transduction R-HSA-162582
Interleukin-2 signaling R-HSA-9020558
Interferon alpha/beta signaling R-HSA-909733
Interleukin-10 signaling R-HSA-6783783
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Regulation of IFNG signaling R-HSA-877312
MAPK1/MAPK3 signaling R-HSA-5684996
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV-2-host interactions R-HSA-9705683
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Disease R-HSA-1643685
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-7 signaling R-HSA-1266695
MAPK family signaling cascades R-HSA-5683057
Signaling by Interleukins R-HSA-449147
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interleukin-12 signaling R-HSA-9020591
Interleukin receptor SHC signaling R-HSA-912526
Other interleukin signaling R-HSA-449836
Interleukin-9 signaling R-HSA-8985947
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-2 family signaling R-HSA-451927
Interferon Signaling R-HSA-913531
Interferon gamma signaling R-HSA-877300
Interleukin-15 signaling R-HSA-8983432
Infectious disease R-HSA-5663205
Interleukin-7 signaling R-HSA-1266695
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-6 signaling R-HSA-1059683
RAF/MAP kinase cascade R-HSA-5673001
Interferon gamma signaling R-HSA-877300
Interleukin-12 family signaling R-HSA-447115
Regulation of IFNG signaling R-HSA-877312
SARS-CoV-2-host interactions R-HSA-9705683
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interferon Signaling R-HSA-913531
Interleukin-2 signaling R-HSA-9020558
Regulation of IFNA/IFNB signaling R-HSA-912694
Other interleukin signaling R-HSA-449836
Interleukin-21 signaling R-HSA-9020958
Signaling by Interleukins R-HSA-449147
Disease R-HSA-1643685
Interleukin-10 signaling R-HSA-6783783
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Interleukin-20 family signaling R-HSA-8854691
Interleukin-6 family signaling R-HSA-6783589
SARS-CoV Infections R-HSA-9679506
Immune System R-HSA-168256
Interleukin-9 signaling R-HSA-8985947
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin receptor SHC signaling R-HSA-912526
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-27 signaling R-HSA-9020956
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interleukin-12 signaling R-HSA-9020591
MAPK3 (ERK1) activation R-HSA-110056
Potential therapeutics for SARS R-HSA-9679191
Interleukin-2 family signaling R-HSA-451927
Interleukin-35 Signalling R-HSA-8984722
Signal Transduction R-HSA-162582
MAPK1 (ERK2) activation R-HSA-112411
MAPK family signaling cascades R-HSA-5683057
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
ISG15 antiviral mechanism R-HSA-1169408
Interferon alpha/beta signaling R-HSA-909733
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interferon alpha/beta signaling R-HSA-909733
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Regulation of IFNG signaling R-HSA-877312
Immune System R-HSA-168256
Regulation of IFNA/IFNB signaling R-HSA-912694
Interferon gamma signaling R-HSA-877300
Disease R-HSA-1643685
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-2 family signaling R-HSA-451927
Signal Transduction R-HSA-162582
MAPK1 (ERK2) activation R-HSA-112411
Interferon Signaling R-HSA-913531
SARS-CoV-2 Infection R-HSA-9694516
ISG15 antiviral mechanism R-HSA-1169408
Interleukin-6 signaling R-HSA-1059683
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-10 signaling R-HSA-6783783
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Interleukin-15 signaling R-HSA-8983432
Interleukin-35 Signalling R-HSA-8984722
Interleukin-12 signaling R-HSA-9020591
MAPK family signaling cascades R-HSA-5683057
Interleukin-6 family signaling R-HSA-6783589
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-12 family signaling R-HSA-447115
SARS-CoV Infections R-HSA-9679506
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interleukin-21 signaling R-HSA-9020958
Interleukin-9 signaling R-HSA-8985947
SARS-CoV-2-host interactions R-HSA-9705683
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-20 family signaling R-HSA-8854691
Interleukin receptor SHC signaling R-HSA-912526
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Potential therapeutics for SARS R-HSA-9679191
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Signaling by Interleukins R-HSA-449147
RAF/MAP kinase cascade R-HSA-5673001
Infectious disease R-HSA-5663205
Other interleukin signaling R-HSA-449836
Interleukin-27 signaling R-HSA-9020956
Interleukin-2 signaling R-HSA-9020558
Interleukin-7 signaling R-HSA-1266695
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Interleukin-20 family signaling R-HSA-8854691
Signaling by CSF3 (G-CSF) R-HSA-9674555
SARS-CoV-2 Infection R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interferon alpha/beta signaling R-HSA-909733
MAPK family signaling cascades R-HSA-5683057
Interleukin-2 family signaling R-HSA-451927
SARS-CoV-2-host interactions R-HSA-9705683
Signal Transduction R-HSA-162582
ISG15 antiviral mechanism R-HSA-1169408
Interleukin-7 signaling R-HSA-1266695
Interleukin-10 signaling R-HSA-6783783
Interleukin-21 signaling R-HSA-9020958
Interleukin receptor SHC signaling R-HSA-912526
MAPK1/MAPK3 signaling R-HSA-5684996
Disease R-HSA-1643685
Regulation of IFNG signaling R-HSA-877312
Interleukin-15 signaling R-HSA-8983432
Other interleukin signaling R-HSA-449836
Signaling by Interleukins R-HSA-449147
Interleukin-2 signaling R-HSA-9020558
Interferon Signaling R-HSA-913531
MAPK3 (ERK1) activation R-HSA-110056
SARS-CoV Infections R-HSA-9679506
Interleukin-9 signaling R-HSA-8985947
Interleukin-12 signaling R-HSA-9020591
Interferon gamma signaling R-HSA-877300
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-6 family signaling R-HSA-6783589
Infectious disease R-HSA-5663205
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Interleukin-35 Signalling R-HSA-8984722
Immune System R-HSA-168256
Regulation of IFNA/IFNB signaling R-HSA-912694
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
RAF/MAP kinase cascade R-HSA-5673001
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-6 signaling R-HSA-1059683
Potential therapeutics for SARS R-HSA-9679191
Interleukin-12 family signaling R-HSA-447115
Interleukin-27 signaling R-HSA-9020956
Cytokine Signaling in Immune system R-HSA-1280215
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-21 signaling R-HSA-9020958
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Interleukin-2 family signaling R-HSA-451927
Interleukin-7 signaling R-HSA-1266695
Signaling by CSF3 (G-CSF) R-HSA-9674555
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interleukin-35 Signalling R-HSA-8984722
MAPK1/MAPK3 signaling R-HSA-5684996
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Immune System R-HSA-168256
Interleukin-20 family signaling R-HSA-8854691
Regulation of IFNG signaling R-HSA-877312
SARS-CoV-2 Infection R-HSA-9694516
MAPK3 (ERK1) activation R-HSA-110056
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-9 signaling R-HSA-8985947
Other interleukin signaling R-HSA-449836
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Interleukin-6 family signaling R-HSA-6783589
MAPK family signaling cascades R-HSA-5683057
MAPK1 (ERK2) activation R-HSA-112411
Interleukin receptor SHC signaling R-HSA-912526
Signaling by Interleukins R-HSA-449147
Signal Transduction R-HSA-162582
SARS-CoV Infections R-HSA-9679506
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
ISG15 antiviral mechanism R-HSA-1169408
Interleukin-12 family signaling R-HSA-447115
Disease R-HSA-1643685
Interferon gamma signaling R-HSA-877300
Infectious disease R-HSA-5663205
Interferon Signaling R-HSA-913531
Interleukin-12 signaling R-HSA-9020591
Potential therapeutics for SARS R-HSA-9679191
Interleukin-27 signaling R-HSA-9020956
Regulation of IFNA/IFNB signaling R-HSA-912694
Interferon alpha/beta signaling R-HSA-909733
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Interleukin-10 signaling R-HSA-6783783
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-6 signaling R-HSA-1059683
Interleukin-2 signaling R-HSA-9020558
SARS-CoV-2-host interactions R-HSA-9705683
Interleukin-15 signaling R-HSA-8983432
ISG15 antiviral mechanism R-HSA-1169408
Interleukin-7 signaling R-HSA-1266695
Immune System R-HSA-168256
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
RAF/MAP kinase cascade R-HSA-5673001
MAPK1/MAPK3 signaling R-HSA-5684996
SARS-CoV-2-host interactions R-HSA-9705683
Potential therapeutics for SARS R-HSA-9679191
Interleukin-27 signaling R-HSA-9020956
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Interleukin-20 family signaling R-HSA-8854691
Interleukin-15 signaling R-HSA-8983432
Interleukin-2 family signaling R-HSA-451927
Interleukin-10 signaling R-HSA-6783783
SARS-CoV Infections R-HSA-9679506
Interleukin-2 signaling R-HSA-9020558
Interleukin-35 Signalling R-HSA-8984722
Regulation of IFNG signaling R-HSA-877312
Signal Transduction R-HSA-162582
Interleukin-21 signaling R-HSA-9020958
Disease R-HSA-1643685
Interleukin-6 family signaling R-HSA-6783589
Interferon Signaling R-HSA-913531
RAF-independent MAPK1/3 activation R-HSA-112409
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
MAPK1 (ERK2) activation R-HSA-112411
Cytokine Signaling in Immune system R-HSA-1280215
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-6 signaling R-HSA-1059683
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
MAPK family signaling cascades R-HSA-5683057
Interferon alpha/beta signaling R-HSA-909733
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin receptor SHC signaling R-HSA-912526
Infectious disease R-HSA-5663205
Interleukin-12 signaling R-HSA-9020591
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-12 family signaling R-HSA-447115
Interleukin-9 signaling R-HSA-8985947
Signaling by Interleukins R-HSA-449147
Other interleukin signaling R-HSA-449836
Interferon gamma signaling R-HSA-877300
Infectious disease R-HSA-5663205
Interleukin-9 signaling R-HSA-8985947
Interferon Signaling R-HSA-913531
Disease R-HSA-1643685
Interleukin-6 signaling R-HSA-1059683
MAPK1 (ERK2) activation R-HSA-112411
RAF-independent MAPK1/3 activation R-HSA-112409
Other interleukin signaling R-HSA-449836
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
RAF/MAP kinase cascade R-HSA-5673001
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-12 family signaling R-HSA-447115
MAPK family signaling cascades R-HSA-5683057
Immune System R-HSA-168256
Interleukin receptor SHC signaling R-HSA-912526
SARS-CoV-2-host interactions R-HSA-9705683
Regulation of IFNG signaling R-HSA-877312
Interleukin-2 family signaling R-HSA-451927
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin-10 signaling R-HSA-6783783
MAPK1/MAPK3 signaling R-HSA-5684996
Interferon gamma signaling R-HSA-877300
Interleukin-20 family signaling R-HSA-8854691
Signaling by Interleukins R-HSA-449147
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-27 signaling R-HSA-9020956
Antiviral mechanism by IFN-stimulated genes R-HSA-1169410
Interferon alpha/beta signaling R-HSA-909733
Interleukin-15 signaling R-HSA-8983432
Interleukin-2 signaling R-HSA-9020558
Interleukin-21 signaling R-HSA-9020958
MAPK3 (ERK1) activation R-HSA-110056
Cytokine Signaling in Immune system R-HSA-1280215
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
ISG15 antiviral mechanism R-HSA-1169408
Interleukin-7 signaling R-HSA-1266695
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
SARS-CoV Infections R-HSA-9679506
Interleukin-35 Signalling R-HSA-8984722
Potential therapeutics for SARS R-HSA-9679191
SARS-CoV-2 Infection R-HSA-9694516
Signal Transduction R-HSA-162582
Interleukin-6 family signaling R-HSA-6783589
Interleukin-12 signaling R-HSA-9020591

Expression Atlas ENSG00000162434
LRG display in Ensembl gene LRG_1398
NCBI gene (formerly Entrezgene) 3716
GeneCards 6190
HGNC Symbol HGNC:6190
MIM gene 147795
MIM morbid 618999
UniProtKB Gene Name P23458
WikiGene 3716
Gene: PDGFRA
Ensembl ID : ENSG00000134853
Description: platelet derived growth factor receptor alpha
Gene Synonyms: CD140A,GAS9,PDGFR2
29 APIs:
204 Possible Orthologues:

RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by PDGF R-HSA-186797
PI3K/AKT Signaling in Cancer R-HSA-2219528
Sunitinib-resistant PDGFR mutants R-HSA-9674401
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Imatinib-resistant PDGFR mutants R-HSA-9674396
Drug resistance of PDGFR mutants R-HSA-9674415
MAPK family signaling cascades R-HSA-5683057
PDGFR mutants bind TKIs R-HSA-9674428
MAPK1/MAPK3 signaling R-HSA-5684996
Disease R-HSA-1643685
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Downstream signal transduction R-HSA-186763
Signaling by PDGFR in disease R-HSA-9671555
Signal Transduction R-HSA-162582
PIP3 activates AKT signaling R-HSA-1257604
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Intracellular signaling by second messengers R-HSA-9006925
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Downstream signal transduction R-HSA-186763
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Sunitinib-resistant PDGFR mutants R-HSA-9674401
RAF/MAP kinase cascade R-HSA-5673001
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Regorafenib-resistant PDGFR mutants R-HSA-9674403
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Negative regulation of the PI3K/AKT network R-HSA-199418
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K/AKT Signaling in Cancer R-HSA-2219528
Disease R-HSA-1643685
PDGFR mutants bind TKIs R-HSA-9674428
Imatinib-resistant PDGFR mutants R-HSA-9674396
PIP3 activates AKT signaling R-HSA-1257604
Signaling by PDGFR in disease R-HSA-9671555
Drug resistance of PDGFR mutants R-HSA-9674415
Signaling by PDGF R-HSA-186797
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
RAF/MAP kinase cascade R-HSA-5673001
PI3K/AKT Signaling in Cancer R-HSA-2219528
PIP3 activates AKT signaling R-HSA-1257604
Signal Transduction R-HSA-162582
Signaling by PDGF R-HSA-186797
Signaling by PDGFR in disease R-HSA-9671555
Downstream signal transduction R-HSA-186763
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
MAPK1/MAPK3 signaling R-HSA-5684996
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAPK family signaling cascades R-HSA-5683057
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Negative regulation of the PI3K/AKT network R-HSA-199418
Imatinib-resistant PDGFR mutants R-HSA-9674396
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PDGFR mutants bind TKIs R-HSA-9674428
Disease R-HSA-1643685
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Sunitinib-resistant PDGFR mutants R-HSA-9674401
Drug resistance of PDGFR mutants R-HSA-9674415
Imatinib-resistant PDGFR mutants R-HSA-9674396
PI3K/AKT Signaling in Cancer R-HSA-2219528
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Sunitinib-resistant PDGFR mutants R-HSA-9674401
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Drug resistance of PDGFR mutants R-HSA-9674415
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of the PI3K/AKT network R-HSA-199418
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by PDGFR in disease R-HSA-9671555
PDGFR mutants bind TKIs R-HSA-9674428
Disease R-HSA-1643685
Signaling by PDGF R-HSA-186797
Sorafenib-resistant PDGFR mutants R-HSA-9674404
MAPK1/MAPK3 signaling R-HSA-5684996
Intracellular signaling by second messengers R-HSA-9006925
Downstream signal transduction R-HSA-186763
PIP3 activates AKT signaling R-HSA-1257604
MAPK1/MAPK3 signaling R-HSA-5684996
Downstream signal transduction R-HSA-186763
Signaling by PDGF R-HSA-186797
Signaling by PDGFR in disease R-HSA-9671555
RAF/MAP kinase cascade R-HSA-5673001
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Disease R-HSA-1643685
PDGFR mutants bind TKIs R-HSA-9674428
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal Transduction R-HSA-162582
Drug resistance of PDGFR mutants R-HSA-9674415
Imatinib-resistant PDGFR mutants R-HSA-9674396
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Intracellular signaling by second messengers R-HSA-9006925
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Sunitinib-resistant PDGFR mutants R-HSA-9674401
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K/AKT Signaling in Cancer R-HSA-2219528
Regorafenib-resistant PDGFR mutants R-HSA-9674403
MAPK family signaling cascades R-HSA-5683057
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PIP3 activates AKT signaling R-HSA-1257604
Signaling by PDGFR in disease R-HSA-9671555
Downstream signal transduction R-HSA-186763
Sunitinib-resistant PDGFR mutants R-HSA-9674401
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K/AKT Signaling in Cancer R-HSA-2219528
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Intracellular signaling by second messengers R-HSA-9006925
Disease R-HSA-1643685
Imatinib-resistant PDGFR mutants R-HSA-9674396
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
PDGFR mutants bind TKIs R-HSA-9674428
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by PDGF R-HSA-186797
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
PIP3 activates AKT signaling R-HSA-1257604
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
MAPK1/MAPK3 signaling R-HSA-5684996
Drug resistance of PDGFR mutants R-HSA-9674415
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
Sunitinib-resistant PDGFR mutants R-HSA-9674401
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by PDGFR in disease R-HSA-9671555
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
PDGFR mutants bind TKIs R-HSA-9674428
MAPK1/MAPK3 signaling R-HSA-5684996
Downstream signal transduction R-HSA-186763
Drug resistance of PDGFR mutants R-HSA-9674415
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Imatinib-resistant PDGFR mutants R-HSA-9674396
Signal Transduction R-HSA-162582
Negative regulation of the PI3K/AKT network R-HSA-199418
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by PDGF R-HSA-186797
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Disease R-HSA-1643685
RAF/MAP kinase cascade R-HSA-5673001
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by PDGF R-HSA-186797
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Disease R-HSA-1643685
Drug resistance of PDGFR mutants R-HSA-9674415
PDGFR mutants bind TKIs R-HSA-9674428
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signal Transduction R-HSA-162582
PI3K/AKT Signaling in Cancer R-HSA-2219528
Intracellular signaling by second messengers R-HSA-9006925
Negative regulation of the PI3K/AKT network R-HSA-199418
Sunitinib-resistant PDGFR mutants R-HSA-9674401
Downstream signal transduction R-HSA-186763
PIP3 activates AKT signaling R-HSA-1257604
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Imatinib-resistant PDGFR mutants R-HSA-9674396
MAPK family signaling cascades R-HSA-5683057
Signaling by PDGFR in disease R-HSA-9671555
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF/MAP kinase cascade R-HSA-5673001
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of the PI3K/AKT network R-HSA-199418
MAPK1/MAPK3 signaling R-HSA-5684996
Downstream signal transduction R-HSA-186763
Sunitinib-resistant PDGFR mutants R-HSA-9674401
PI3K/AKT Signaling in Cancer R-HSA-2219528
MAPK family signaling cascades R-HSA-5683057
Drug resistance of PDGFR mutants R-HSA-9674415
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Imatinib-resistant PDGFR mutants R-HSA-9674396
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
PDGFR mutants bind TKIs R-HSA-9674428
Signaling by PDGFR in disease R-HSA-9671555
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regorafenib-resistant PDGFR mutants R-HSA-9674403
PIP3 activates AKT signaling R-HSA-1257604
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
Signaling by PDGF R-HSA-186797
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
RAF/MAP kinase cascade R-HSA-5673001
Drug resistance of PDGFR mutants R-HSA-9674415
PDGFR mutants bind TKIs R-HSA-9674428
MAPK1/MAPK3 signaling R-HSA-5684996
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Regorafenib-resistant PDGFR mutants R-HSA-9674403
Downstream signal transduction R-HSA-186763
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Sunitinib-resistant PDGFR mutants R-HSA-9674401
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
Sorafenib-resistant PDGFR mutants R-HSA-9674404
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Imatinib-resistant PDGFR mutants R-HSA-9674396
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signal Transduction R-HSA-162582
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by PDGF R-HSA-186797
MAPK family signaling cascades R-HSA-5683057
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by PDGFR in disease R-HSA-9671555
Negative regulation of the PI3K/AKT network R-HSA-199418

Expression Atlas ENSG00000134853
LRG display in Ensembl gene LRG_309
NCBI gene (formerly Entrezgene) 5156
GeneCards 8803
HGNC Symbol HGNC:8803
MIM gene 173490
MIM morbid 607685
UniProtKB Gene Name P16234
WikiGene 5156
Gene: EPHA3
Ensembl ID : ENSG00000044524
Description: EPH receptor A3
Gene Synonyms: ETK,ETK1,HEK,HEK4,TYRO4
1 APIs:
215 Possible Orthologues:

Developmental Biology R-HSA-1266738
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
EPHA-mediated growth cone collapse R-HSA-3928663
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nervous system development R-HSA-9675108
EPH-ephrin mediated repulsion of cells R-HSA-3928665
EPH-Ephrin signaling R-HSA-2682334
Nervous system development R-HSA-9675108
Developmental Biology R-HSA-1266738
Axon guidance R-HSA-422475
EPHA-mediated growth cone collapse R-HSA-3928663
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
EPH-ephrin mediated repulsion of cells R-HSA-3928665
EPHA-mediated growth cone collapse R-HSA-3928663
EPH-Ephrin signaling R-HSA-2682334
Nervous system development R-HSA-9675108
EPHA-mediated growth cone collapse R-HSA-3928663
Nervous system development R-HSA-9675108
EPH-ephrin mediated repulsion of cells R-HSA-3928665
EPH-Ephrin signaling R-HSA-2682334
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
EPHA-mediated growth cone collapse R-HSA-3928663
EPH-Ephrin signaling R-HSA-2682334
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
EPHA-mediated growth cone collapse R-HSA-3928663
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
EPH-Ephrin signaling R-HSA-2682334
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
EPH-Ephrin signaling R-HSA-2682334
EPHA-mediated growth cone collapse R-HSA-3928663
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
Developmental Biology R-HSA-1266738
Axon guidance R-HSA-422475
EPH-ephrin mediated repulsion of cells R-HSA-3928665
EPHA-mediated growth cone collapse R-HSA-3928663
Nervous system development R-HSA-9675108
Developmental Biology R-HSA-1266738
Axon guidance R-HSA-422475
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nervous system development R-HSA-9675108
EPHA-mediated growth cone collapse R-HSA-3928663
EPH-Ephrin signaling R-HSA-2682334
EPHA-mediated growth cone collapse R-HSA-3928663
Developmental Biology R-HSA-1266738
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
Nervous system development R-HSA-9675108

Expression Atlas ENSG00000044524
NCBI gene (formerly Entrezgene) 2042
GeneCards 3387
HGNC Symbol HGNC:3387
MIM gene 179611
UniProtKB Gene Name P29320
WikiGene 2042
Gene: TYK2
Ensembl ID : ENSG00000105397
Description: tyrosine kinase 2
Gene Synonyms: JTK1
10 APIs:
197 Possible Orthologues:

RAF-independent MAPK1/3 activation R-HSA-112409
Immune System R-HSA-168256
Interleukin-6 family signaling R-HSA-6783589
Interleukin-12 family signaling R-HSA-447115
Signaling by Interleukins R-HSA-449147
Interferon Signaling R-HSA-913531
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interferon alpha/beta signaling R-HSA-909733
Infectious disease R-HSA-5663205
MAPK3 (ERK1) activation R-HSA-110056
Potential therapeutics for SARS R-HSA-9679191
SARS-CoV Infections R-HSA-9679506
Regulation of IFNA/IFNB signaling R-HSA-912694
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-10 signaling R-HSA-6783783
Interleukin-35 Signalling R-HSA-8984722
Interleukin-6 signaling R-HSA-1059683
MAPK1/MAPK3 signaling R-HSA-5684996
Disease R-HSA-1643685
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
SARS-CoV-2-host interactions R-HSA-9705683
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Interleukin-27 signaling R-HSA-9020956
MAPK1 (ERK2) activation R-HSA-112411
Cytokine Signaling in Immune system R-HSA-1280215
MAPK family signaling cascades R-HSA-5683057
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-20 family signaling R-HSA-8854691
Signal Transduction R-HSA-162582
Interleukin-23 signaling R-HSA-9020933
Interleukin-12 signaling R-HSA-9020591
Other interleukin signaling R-HSA-449836
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interleukin-23 signaling R-HSA-9020933
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-6 signaling R-HSA-1059683
Infectious disease R-HSA-5663205
Interferon alpha/beta signaling R-HSA-909733
Interferon Signaling R-HSA-913531
Cytokine Signaling in Immune system R-HSA-1280215
Potential therapeutics for SARS R-HSA-9679191
Interleukin-35 Signalling R-HSA-8984722
MAPK family signaling cascades R-HSA-5683057
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin-12 signaling R-HSA-9020591
Signaling by CSF3 (G-CSF) R-HSA-9674555
Disease R-HSA-1643685
Interleukin-12 family signaling R-HSA-447115
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signaling by Interleukins R-HSA-449147
Interleukin-6 family signaling R-HSA-6783589
Interleukin-10 signaling R-HSA-6783783
Signal Transduction R-HSA-162582
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Other interleukin signaling R-HSA-449836
Interleukin-27 signaling R-HSA-9020956
SARS-CoV Infections R-HSA-9679506
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
MAPK1 (ERK2) activation R-HSA-112411
MAPK3 (ERK1) activation R-HSA-110056
SARS-CoV-2 Infection R-HSA-9694516
SARS-CoV-2-host interactions R-HSA-9705683
RAF-independent MAPK1/3 activation R-HSA-112409
Immune System R-HSA-168256
Interleukin-20 family signaling R-HSA-8854691
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
SARS-CoV Infections R-HSA-9679506
Signaling by Interleukins R-HSA-449147
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
MAPK family signaling cascades R-HSA-5683057
Other interleukin signaling R-HSA-449836
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-6 family signaling R-HSA-6783589
Interleukin-23 signaling R-HSA-9020933
SARS-CoV-2-host interactions R-HSA-9705683
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Regulation of IFNA/IFNB signaling R-HSA-912694
Infectious disease R-HSA-5663205
MAPK3 (ERK1) activation R-HSA-110056
Potential therapeutics for SARS R-HSA-9679191
Disease R-HSA-1643685
Interleukin-27 signaling R-HSA-9020956
Interferon Signaling R-HSA-913531
Interleukin-10 signaling R-HSA-6783783
Interleukin-20 family signaling R-HSA-8854691
Interleukin-35 Signalling R-HSA-8984722
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-12 family signaling R-HSA-447115
Interferon alpha/beta signaling R-HSA-909733
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-6 signaling R-HSA-1059683
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-12 signaling R-HSA-9020591
Signal Transduction R-HSA-162582
Signaling by Interleukins R-HSA-449147
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-6 family signaling R-HSA-6783589
Interferon Signaling R-HSA-913531
Interleukin-27 signaling R-HSA-9020956
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Potential therapeutics for SARS R-HSA-9679191
MAPK3 (ERK1) activation R-HSA-110056
Signaling by CSF3 (G-CSF) R-HSA-9674555
MAPK1/MAPK3 signaling R-HSA-5684996
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Immune System R-HSA-168256
Disease R-HSA-1643685
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV Infections R-HSA-9679506
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-6 signaling R-HSA-1059683
SARS-CoV-2 Infection R-HSA-9694516
Other interleukin signaling R-HSA-449836
Interleukin-20 family signaling R-HSA-8854691
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-35 Signalling R-HSA-8984722
RAF-independent MAPK1/3 activation R-HSA-112409
SARS-CoV-2-host interactions R-HSA-9705683
Interferon alpha/beta signaling R-HSA-909733
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin-10 signaling R-HSA-6783783
Interleukin-12 signaling R-HSA-9020591
MAPK family signaling cascades R-HSA-5683057
Interleukin-23 signaling R-HSA-9020933
Interleukin-12 family signaling R-HSA-447115
Infectious disease R-HSA-5663205
Other interleukin signaling R-HSA-449836
Interleukin-20 family signaling R-HSA-8854691
SARS-CoV Infections R-HSA-9679506
Potential therapeutics for SARS R-HSA-9679191
Interleukin-10 signaling R-HSA-6783783
Regulation of IFNA/IFNB signaling R-HSA-912694
Signaling by CSF3 (G-CSF) R-HSA-9674555
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interferon alpha/beta signaling R-HSA-909733
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-12 signaling R-HSA-9020591
Interleukin-6 family signaling R-HSA-6783589
Signaling by Interleukins R-HSA-449147
Interleukin-35 Signalling R-HSA-8984722
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-23 signaling R-HSA-9020933
Disease R-HSA-1643685
Immune System R-HSA-168256
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV-2 Infection R-HSA-9694516
Interleukin-27 signaling R-HSA-9020956
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-6 signaling R-HSA-1059683
Signal Transduction R-HSA-162582
Interferon Signaling R-HSA-913531
MAPK family signaling cascades R-HSA-5683057
Interleukin-12 family signaling R-HSA-447115
Infectious disease R-HSA-5663205
SARS-CoV-2-host interactions R-HSA-9705683
RAF-independent MAPK1/3 activation R-HSA-112409
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-27 signaling R-HSA-9020956
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV-2-host interactions R-HSA-9705683
MAPK family signaling cascades R-HSA-5683057
Disease R-HSA-1643685
Interferon alpha/beta signaling R-HSA-909733
SARS-CoV-2 Infection R-HSA-9694516
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-23 signaling R-HSA-9020933
Interferon Signaling R-HSA-913531
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interleukin-6 family signaling R-HSA-6783589
MAPK1/MAPK3 signaling R-HSA-5684996
Regulation of IFNA/IFNB signaling R-HSA-912694
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Infectious disease R-HSA-5663205
Interleukin-10 signaling R-HSA-6783783
MAPK1 (ERK2) activation R-HSA-112411
Immune System R-HSA-168256
SARS-CoV Infections R-HSA-9679506
Signaling by Interleukins R-HSA-449147
Potential therapeutics for SARS R-HSA-9679191
Signal Transduction R-HSA-162582
MAPK3 (ERK1) activation R-HSA-110056
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-12 family signaling R-HSA-447115
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-12 signaling R-HSA-9020591
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-6 signaling R-HSA-1059683
Interleukin-20 family signaling R-HSA-8854691
Other interleukin signaling R-HSA-449836
Interleukin-35 Signalling R-HSA-8984722
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-27 signaling R-HSA-9020956
Cytokine Signaling in Immune system R-HSA-1280215
MAPK1/MAPK3 signaling R-HSA-5684996
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
MAPK3 (ERK1) activation R-HSA-110056
Signaling by Interleukins R-HSA-449147
Interleukin-6 signaling R-HSA-1059683
Signaling by CSF3 (G-CSF) R-HSA-9674555
SARS-CoV Infections R-HSA-9679506
Other interleukin signaling R-HSA-449836
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Potential therapeutics for SARS R-HSA-9679191
Interleukin-12 family signaling R-HSA-447115
Interleukin-35 Signalling R-HSA-8984722
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-20 family signaling R-HSA-8854691
Interleukin-10 signaling R-HSA-6783783
SARS-CoV-2 Infection R-HSA-9694516
Immune System R-HSA-168256
Interferon alpha/beta signaling R-HSA-909733
Interferon Signaling R-HSA-913531
Regulation of IFNA/IFNB signaling R-HSA-912694
SARS-CoV-2-host interactions R-HSA-9705683
Interleukin-6 family signaling R-HSA-6783589
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interleukin-12 signaling R-HSA-9020591
Infectious disease R-HSA-5663205
Signal Transduction R-HSA-162582
Interleukin-23 signaling R-HSA-9020933
Disease R-HSA-1643685
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
MAPK1 (ERK2) activation R-HSA-112411
RAF-independent MAPK1/3 activation R-HSA-112409
MAPK family signaling cascades R-HSA-5683057
Interleukin-20 family signaling R-HSA-8854691
Potential therapeutics for SARS R-HSA-9679191
Interleukin-23 signaling R-HSA-9020933
SARS-CoV-2-host interactions R-HSA-9705683
Interleukin-35 Signalling R-HSA-8984722
Signaling by CSF3 (G-CSF) R-HSA-9674555
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV-2 Infection R-HSA-9694516
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Immune System R-HSA-168256
MAPK3 (ERK1) activation R-HSA-110056
Interferon Signaling R-HSA-913531
Interleukin-10 signaling R-HSA-6783783
Interferon alpha/beta signaling R-HSA-909733
Signaling by Interleukins R-HSA-449147
Infectious disease R-HSA-5663205
Interleukin-27 signaling R-HSA-9020956
Regulation of IFNA/IFNB signaling R-HSA-912694
SARS-CoV Infections R-HSA-9679506
Interleukin-6 family signaling R-HSA-6783589
Interleukin-12 signaling R-HSA-9020591
Disease R-HSA-1643685
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-12 family signaling R-HSA-447115
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Other interleukin signaling R-HSA-449836
Interleukin-6 signaling R-HSA-1059683
MAPK1/MAPK3 signaling R-HSA-5684996
Disease R-HSA-1643685
Interferon alpha/beta signaling R-HSA-909733
Interleukin-27 signaling R-HSA-9020956
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-20 family signaling R-HSA-8854691
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-35 Signalling R-HSA-8984722
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
MAPK3 (ERK1) activation R-HSA-110056
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
MAPK family signaling cascades R-HSA-5683057
RAF-independent MAPK1/3 activation R-HSA-112409
SARS-CoV-2 Infection R-HSA-9694516
Potential therapeutics for SARS R-HSA-9679191
Other interleukin signaling R-HSA-449836
Regulation of IFNA/IFNB signaling R-HSA-912694
SARS-CoV Infections R-HSA-9679506
Interleukin-12 family signaling R-HSA-447115
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signal Transduction R-HSA-162582
SARS-CoV-2-host interactions R-HSA-9705683
Cytokine Signaling in Immune system R-HSA-1280215
Infectious disease R-HSA-5663205
Interleukin-10 signaling R-HSA-6783783
Interleukin-23 signaling R-HSA-9020933
Interleukin-6 family signaling R-HSA-6783589
Interleukin-6 signaling R-HSA-1059683
Interleukin-12 signaling R-HSA-9020591
Interferon Signaling R-HSA-913531
Infectious disease R-HSA-5663205
SARS-CoV-2 Infection R-HSA-9694516
Signaling by CSF3 (G-CSF) R-HSA-9674555
Disease R-HSA-1643685
Interleukin-12 family signaling R-HSA-447115
Interferon Signaling R-HSA-913531
Interleukin-27 signaling R-HSA-9020956
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-20 family signaling R-HSA-8854691
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Signaling by Interleukins R-HSA-449147
Interleukin-10 signaling R-HSA-6783783
MAPK family signaling cascades R-HSA-5683057
Immune System R-HSA-168256
SARS-CoV-2-host interactions R-HSA-9705683
Interferon alpha/beta signaling R-HSA-909733
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Potential therapeutics for SARS R-HSA-9679191
MAPK3 (ERK1) activation R-HSA-110056
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Regulation of IFNA/IFNB signaling R-HSA-912694
RAF-independent MAPK1/3 activation R-HSA-112409
Cytokine Signaling in Immune system R-HSA-1280215
Other interleukin signaling R-HSA-449836
SARS-CoV Infections R-HSA-9679506
Interleukin-35 Signalling R-HSA-8984722
Interleukin-6 family signaling R-HSA-6783589
Interleukin-6 signaling R-HSA-1059683
Interleukin-23 signaling R-HSA-9020933
Interleukin-12 signaling R-HSA-9020591
Signal Transduction R-HSA-162582
MAPK1 (ERK2) activation R-HSA-112411
MAPK1/MAPK3 signaling R-HSA-5684996

Expression Atlas ENSG00000105397
LRG display in Ensembl gene LRG_121
NCBI gene (formerly Entrezgene) 7297
GeneCards 12440
HGNC Symbol HGNC:12440
MIM gene 176941
MIM morbid 611521
UniProtKB Gene Name P29597
WikiGene 7297