Gene: MAP3K9
Ensembl ID : ENSG00000006432
Description: mitogen-activated protein kinase kinase kinase 9
Gene Synonyms: MEKK9,MLK1,PRKE1
1 APIs:
195 Possible Orthologues:

Expression Atlas ENSG00000006432
NCBI gene (formerly Entrezgene) 4293
GeneCards 6861
HGNC Symbol HGNC:6861
MIM gene 600136
UniProtKB Gene Name P80192
WikiGene 4293
Gene: FLT3
Ensembl ID : ENSG00000122025
Description: fms related receptor tyrosine kinase 3
Gene Synonyms: CD135,FLK2,STK1
41 APIs:
134 Possible Orthologues:

tamatinib-resistant FLT3 mutants R-HSA-9703009
Immune System R-HSA-168256
STAT5 Activation R-HSA-9645135
Insulin receptor signalling cascade R-HSA-74751
gilteritinib-resistant FLT3 mutants R-HSA-9702590
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
FLT3 Signaling R-HSA-9607240
quizartinib-resistant FLT3 mutants R-HSA-9702620
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Insulin receptor R-HSA-74752
ponatinib-resistant FLT3 mutants R-HSA-9702614
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
crenolanib-resistant FLT3 mutants R-HSA-9702581
Negative regulation of the PI3K/AKT network R-HSA-199418
FLT3 signaling by CBL mutants R-HSA-9706377
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
sorafenib-resistant FLT3 mutants R-HSA-9702624
Drug resistance of FLT3 mutants R-HSA-9702506
linifanib-resistant FLT3 mutants R-HSA-9702998
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
tamatinib-resistant FLT3 mutants R-HSA-9703009
PI3K/AKT Signaling in Cancer R-HSA-2219528
semaxanib-resistant FLT3 mutants R-HSA-9702577
sunitinib-resistant FLT3 mutants R-HSA-9702632
Disease R-HSA-1643685
FLT3 mutants bind TKIs R-HSA-9702509
FLT3 signaling through SRC family kinases R-HSA-9706374
FLT3 signaling in disease R-HSA-9682385
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
IGF1R signaling cascade R-HSA-2428924
pexidartinib-resistant FLT3 mutants R-HSA-9702605
Signal Transduction R-HSA-162582
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
KW2449-resistant FLT3 mutants R-HSA-9702569
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF/MAP kinase cascade R-HSA-5673001
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
tandutinib-resistant FLT3 mutants R-HSA-9702636
Cytokine Signaling in Immune system R-HSA-1280215
MAPK family signaling cascades R-HSA-5683057
Negative regulation of FLT3 R-HSA-9706369
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
midostaurin-resistant FLT3 mutants R-HSA-9702600
PI3K Cascade R-HSA-109704
MAPK1/MAPK3 signaling R-HSA-5684996
Insulin receptor signalling cascade R-HSA-74751
linifanib-resistant FLT3 mutants R-HSA-9702998
PIP3 activates AKT signaling R-HSA-1257604
quizartinib-resistant FLT3 mutants R-HSA-9702620
tamatinib-resistant FLT3 mutants R-HSA-9703009
tandutinib-resistant FLT3 mutants R-HSA-9702636
PI3K/AKT Signaling in Cancer R-HSA-2219528
Immune System R-HSA-168256
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Signal Transduction R-HSA-162582
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IRS-related events triggered by IGF1R R-HSA-2428928
KW2449-resistant FLT3 mutants R-HSA-9702569
MAPK family signaling cascades R-HSA-5683057
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
FLT3 mutants bind TKIs R-HSA-9702509
PI3K Cascade R-HSA-109704
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Insulin receptor R-HSA-74752
IRS-mediated signalling R-HSA-112399
gilteritinib-resistant FLT3 mutants R-HSA-9702590
IGF1R signaling cascade R-HSA-2428924
sunitinib-resistant FLT3 mutants R-HSA-9702632
Negative regulation of FLT3 R-HSA-9706369
FLT3 Signaling R-HSA-9607240
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Drug resistance of FLT3 mutants R-HSA-9702506
FLT3 signaling by CBL mutants R-HSA-9706377
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
FLT3 signaling in disease R-HSA-9682385
sorafenib-resistant FLT3 mutants R-HSA-9702624
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
pexidartinib-resistant FLT3 mutants R-HSA-9702605
crenolanib-resistant FLT3 mutants R-HSA-9702581
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Intracellular signaling by second messengers R-HSA-9006925
FLT3 signaling through SRC family kinases R-HSA-9706374
STAT5 Activation R-HSA-9645135
MAPK1/MAPK3 signaling R-HSA-5684996
midostaurin-resistant FLT3 mutants R-HSA-9702600
semaxanib-resistant FLT3 mutants R-HSA-9702577
ponatinib-resistant FLT3 mutants R-HSA-9702614
FLT3 signaling by CBL mutants R-HSA-9706377
Cytokine Signaling in Immune system R-HSA-1280215
IRS-mediated signalling R-HSA-112399
FLT3 signaling in disease R-HSA-9682385
gilteritinib-resistant FLT3 mutants R-HSA-9702590
FLT3 signaling through SRC family kinases R-HSA-9706374
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
PI3K/AKT Signaling in Cancer R-HSA-2219528
midostaurin-resistant FLT3 mutants R-HSA-9702600
IRS-related events triggered by IGF1R R-HSA-2428928
ponatinib-resistant FLT3 mutants R-HSA-9702614
Insulin receptor signalling cascade R-HSA-74751
FLT3 mutants bind TKIs R-HSA-9702509
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
crenolanib-resistant FLT3 mutants R-HSA-9702581
IGF1R signaling cascade R-HSA-2428924
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
sorafenib-resistant FLT3 mutants R-HSA-9702624
Negative regulation of the PI3K/AKT network R-HSA-199418
Intracellular signaling by second messengers R-HSA-9006925
Signaling by Insulin receptor R-HSA-74752
Immune System R-HSA-168256
linifanib-resistant FLT3 mutants R-HSA-9702998
FLT3 Signaling R-HSA-9607240
sunitinib-resistant FLT3 mutants R-HSA-9702632
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
PI3K Cascade R-HSA-109704
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
MAPK family signaling cascades R-HSA-5683057
pexidartinib-resistant FLT3 mutants R-HSA-9702605
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Disease R-HSA-1643685
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
STAT5 Activation R-HSA-9645135
KW2449-resistant FLT3 mutants R-HSA-9702569
Negative regulation of FLT3 R-HSA-9706369
Drug resistance of FLT3 mutants R-HSA-9702506
PIP3 activates AKT signaling R-HSA-1257604
quizartinib-resistant FLT3 mutants R-HSA-9702620
tandutinib-resistant FLT3 mutants R-HSA-9702636
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
tamatinib-resistant FLT3 mutants R-HSA-9703009
semaxanib-resistant FLT3 mutants R-HSA-9702577
crenolanib-resistant FLT3 mutants R-HSA-9702581
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
RAF/MAP kinase cascade R-HSA-5673001
FLT3 Signaling R-HSA-9607240
linifanib-resistant FLT3 mutants R-HSA-9702998
Negative regulation of FLT3 R-HSA-9706369
gilteritinib-resistant FLT3 mutants R-HSA-9702590
MAPK1/MAPK3 signaling R-HSA-5684996
KW2449-resistant FLT3 mutants R-HSA-9702569
ponatinib-resistant FLT3 mutants R-HSA-9702614
FLT3 mutants bind TKIs R-HSA-9702509
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Drug resistance of FLT3 mutants R-HSA-9702506
FLT3 signaling through SRC family kinases R-HSA-9706374
midostaurin-resistant FLT3 mutants R-HSA-9702600
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Immune System R-HSA-168256
quizartinib-resistant FLT3 mutants R-HSA-9702620
Intracellular signaling by second messengers R-HSA-9006925
semaxanib-resistant FLT3 mutants R-HSA-9702577
PIP3 activates AKT signaling R-HSA-1257604
sorafenib-resistant FLT3 mutants R-HSA-9702624
FLT3 signaling in disease R-HSA-9682385
STAT5 Activation R-HSA-9645135
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
tandutinib-resistant FLT3 mutants R-HSA-9702636
sunitinib-resistant FLT3 mutants R-HSA-9702632
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
IRS-mediated signalling R-HSA-112399
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Insulin receptor R-HSA-74752
IGF1R signaling cascade R-HSA-2428924
PI3K Cascade R-HSA-109704
MAPK family signaling cascades R-HSA-5683057
Insulin receptor signalling cascade R-HSA-74751
tamatinib-resistant FLT3 mutants R-HSA-9703009
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
PI3K/AKT Signaling in Cancer R-HSA-2219528
FLT3 signaling by CBL mutants R-HSA-9706377
pexidartinib-resistant FLT3 mutants R-HSA-9702605
Disease R-HSA-1643685
Negative regulation of the PI3K/AKT network R-HSA-199418
quizartinib-resistant FLT3 mutants R-HSA-9702620
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K/AKT Signaling in Cancer R-HSA-2219528
IRS-mediated signalling R-HSA-112399
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IRS-related events triggered by IGF1R R-HSA-2428928
sorafenib-resistant FLT3 mutants R-HSA-9702624
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signal Transduction R-HSA-162582
FLT3 Signaling R-HSA-9607240
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
crenolanib-resistant FLT3 mutants R-HSA-9702581
Insulin receptor signalling cascade R-HSA-74751
Negative regulation of the PI3K/AKT network R-HSA-199418
pexidartinib-resistant FLT3 mutants R-HSA-9702605
tamatinib-resistant FLT3 mutants R-HSA-9703009
Negative regulation of FLT3 R-HSA-9706369
MAPK1/MAPK3 signaling R-HSA-5684996
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
FLT3 signaling in disease R-HSA-9682385
gilteritinib-resistant FLT3 mutants R-HSA-9702590
PI3K Cascade R-HSA-109704
Disease R-HSA-1643685
KW2449-resistant FLT3 mutants R-HSA-9702569
MAPK family signaling cascades R-HSA-5683057
ponatinib-resistant FLT3 mutants R-HSA-9702614
Immune System R-HSA-168256
midostaurin-resistant FLT3 mutants R-HSA-9702600
semaxanib-resistant FLT3 mutants R-HSA-9702577
STAT5 Activation R-HSA-9645135
PIP3 activates AKT signaling R-HSA-1257604
Drug resistance of FLT3 mutants R-HSA-9702506
Signaling by Insulin receptor R-HSA-74752
IGF1R signaling cascade R-HSA-2428924
linifanib-resistant FLT3 mutants R-HSA-9702998
FLT3 signaling by CBL mutants R-HSA-9706377
tandutinib-resistant FLT3 mutants R-HSA-9702636
sunitinib-resistant FLT3 mutants R-HSA-9702632
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
FLT3 mutants bind TKIs R-HSA-9702509
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Intracellular signaling by second messengers R-HSA-9006925
FLT3 signaling through SRC family kinases R-HSA-9706374
Drug resistance of FLT3 mutants R-HSA-9702506
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
IRS-related events triggered by IGF1R R-HSA-2428928
FLT3 signaling by CBL mutants R-HSA-9706377
pexidartinib-resistant FLT3 mutants R-HSA-9702605
sorafenib-resistant FLT3 mutants R-HSA-9702624
gilteritinib-resistant FLT3 mutants R-HSA-9702590
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
linifanib-resistant FLT3 mutants R-HSA-9702998
FLT3 signaling through SRC family kinases R-HSA-9706374
quizartinib-resistant FLT3 mutants R-HSA-9702620
RAF/MAP kinase cascade R-HSA-5673001
Intracellular signaling by second messengers R-HSA-9006925
sunitinib-resistant FLT3 mutants R-HSA-9702632
MAPK family signaling cascades R-HSA-5683057
IGF1R signaling cascade R-HSA-2428924
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Negative regulation of FLT3 R-HSA-9706369
Signal Transduction R-HSA-162582
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
crenolanib-resistant FLT3 mutants R-HSA-9702581
PI3K/AKT Signaling in Cancer R-HSA-2219528
Insulin receptor signalling cascade R-HSA-74751
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Immune System R-HSA-168256
FLT3 mutants bind TKIs R-HSA-9702509
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Insulin receptor R-HSA-74752
semaxanib-resistant FLT3 mutants R-HSA-9702577
tandutinib-resistant FLT3 mutants R-HSA-9702636
Negative regulation of the PI3K/AKT network R-HSA-199418
Cytokine Signaling in Immune system R-HSA-1280215
tamatinib-resistant FLT3 mutants R-HSA-9703009
FLT3 signaling in disease R-HSA-9682385
KW2449-resistant FLT3 mutants R-HSA-9702569
midostaurin-resistant FLT3 mutants R-HSA-9702600
ponatinib-resistant FLT3 mutants R-HSA-9702614
Disease R-HSA-1643685
PIP3 activates AKT signaling R-HSA-1257604
STAT5 Activation R-HSA-9645135
FLT3 Signaling R-HSA-9607240
IRS-mediated signalling R-HSA-112399
PI3K Cascade R-HSA-109704
crenolanib-resistant FLT3 mutants R-HSA-9702581
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
STAT5 Activation R-HSA-9645135
tandutinib-resistant FLT3 mutants R-HSA-9702636
Signaling by Insulin receptor R-HSA-74752
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
MAPK family signaling cascades R-HSA-5683057
Cytokine Signaling in Immune system R-HSA-1280215
IGF1R signaling cascade R-HSA-2428924
Drug resistance of FLT3 mutants R-HSA-9702506
RAF/MAP kinase cascade R-HSA-5673001
PI3K/AKT Signaling in Cancer R-HSA-2219528
IRS-related events triggered by IGF1R R-HSA-2428928
Intracellular signaling by second messengers R-HSA-9006925
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Insulin receptor signalling cascade R-HSA-74751
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
FLT3 signaling through SRC family kinases R-HSA-9706374
sorafenib-resistant FLT3 mutants R-HSA-9702624
gilteritinib-resistant FLT3 mutants R-HSA-9702590
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
IRS-mediated signalling R-HSA-112399
MAPK1/MAPK3 signaling R-HSA-5684996
PI3K Cascade R-HSA-109704
FLT3 signaling by CBL mutants R-HSA-9706377
Negative regulation of the PI3K/AKT network R-HSA-199418
KW2449-resistant FLT3 mutants R-HSA-9702569
linifanib-resistant FLT3 mutants R-HSA-9702998
semaxanib-resistant FLT3 mutants R-HSA-9702577
FLT3 signaling in disease R-HSA-9682385
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
pexidartinib-resistant FLT3 mutants R-HSA-9702605
tamatinib-resistant FLT3 mutants R-HSA-9703009
sunitinib-resistant FLT3 mutants R-HSA-9702632
FLT3 Signaling R-HSA-9607240
FLT3 mutants bind TKIs R-HSA-9702509
Disease R-HSA-1643685
Negative regulation of FLT3 R-HSA-9706369
quizartinib-resistant FLT3 mutants R-HSA-9702620
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
ponatinib-resistant FLT3 mutants R-HSA-9702614
PIP3 activates AKT signaling R-HSA-1257604
midostaurin-resistant FLT3 mutants R-HSA-9702600
Immune System R-HSA-168256
crenolanib-resistant FLT3 mutants R-HSA-9702581
FLT3 signaling through SRC family kinases R-HSA-9706374
Signaling by Insulin receptor R-HSA-74752
tandutinib-resistant FLT3 mutants R-HSA-9702636
IRS-related events triggered by IGF1R R-HSA-2428928
quizartinib-resistant FLT3 mutants R-HSA-9702620
MAPK family signaling cascades R-HSA-5683057
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
FLT3 signaling in disease R-HSA-9682385
PI3K Cascade R-HSA-109704
IRS-mediated signalling R-HSA-112399
sunitinib-resistant FLT3 mutants R-HSA-9702632
Intracellular signaling by second messengers R-HSA-9006925
FLT3 mutants bind TKIs R-HSA-9702509
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
gilteritinib-resistant FLT3 mutants R-HSA-9702590
Signal Transduction R-HSA-162582
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of the PI3K/AKT network R-HSA-199418
FLT3 Signaling R-HSA-9607240
KW2449-resistant FLT3 mutants R-HSA-9702569
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
linifanib-resistant FLT3 mutants R-HSA-9702998
Drug resistance of FLT3 mutants R-HSA-9702506
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Immune System R-HSA-168256
sorafenib-resistant FLT3 mutants R-HSA-9702624
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
semaxanib-resistant FLT3 mutants R-HSA-9702577
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
midostaurin-resistant FLT3 mutants R-HSA-9702600
MAPK1/MAPK3 signaling R-HSA-5684996
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
pexidartinib-resistant FLT3 mutants R-HSA-9702605
ponatinib-resistant FLT3 mutants R-HSA-9702614
FLT3 signaling by CBL mutants R-HSA-9706377
STAT5 Activation R-HSA-9645135
Negative regulation of FLT3 R-HSA-9706369
Disease R-HSA-1643685
Insulin receptor signalling cascade R-HSA-74751
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
IGF1R signaling cascade R-HSA-2428924
Drug resistance of FLT3 mutants R-HSA-9702506
FLT3 signaling by CBL mutants R-HSA-9706377
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
FLT3 Signaling R-HSA-9607240
FLT3 mutants bind TKIs R-HSA-9702509
Negative regulation of the PI3K/AKT network R-HSA-199418
tandutinib-resistant FLT3 mutants R-HSA-9702636
Cytokine Signaling in Immune system R-HSA-1280215
Intracellular signaling by second messengers R-HSA-9006925
gilteritinib-resistant FLT3 mutants R-HSA-9702590
tamatinib-resistant FLT3 mutants R-HSA-9703009
crenolanib-resistant FLT3 mutants R-HSA-9702581
Immune System R-HSA-168256
FLT3 signaling in disease R-HSA-9682385
linifanib-resistant FLT3 mutants R-HSA-9702998
Disease R-HSA-1643685
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PIP3 activates AKT signaling R-HSA-1257604
FLT3 signaling through SRC family kinases R-HSA-9706374
Negative regulation of FLT3 R-HSA-9706369
midostaurin-resistant FLT3 mutants R-HSA-9702600
PI3K Cascade R-HSA-109704
sunitinib-resistant FLT3 mutants R-HSA-9702632
STAT5 Activation R-HSA-9645135
RAF/MAP kinase cascade R-HSA-5673001
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Signaling by Insulin receptor R-HSA-74752
MAPK1/MAPK3 signaling R-HSA-5684996
quizartinib-resistant FLT3 mutants R-HSA-9702620
ponatinib-resistant FLT3 mutants R-HSA-9702614
IRS-related events triggered by IGF1R R-HSA-2428928
Signal Transduction R-HSA-162582
sorafenib-resistant FLT3 mutants R-HSA-9702624
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
pexidartinib-resistant FLT3 mutants R-HSA-9702605
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
semaxanib-resistant FLT3 mutants R-HSA-9702577
IGF1R signaling cascade R-HSA-2428924
MAPK family signaling cascades R-HSA-5683057
KW2449-resistant FLT3 mutants R-HSA-9702569
IRS-mediated signalling R-HSA-112399
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K/AKT Signaling in Cancer R-HSA-2219528
lestaurtinib-resistant FLT3 mutants R-HSA-9702596
Insulin receptor signalling cascade R-HSA-74751
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Insulin receptor R-HSA-74752
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
midostaurin-resistant FLT3 mutants R-HSA-9702600
FLT3 signaling through SRC family kinases R-HSA-9706374
FLT3 Signaling R-HSA-9607240
Immune System R-HSA-168256
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Negative regulation of FLT3 R-HSA-9706369
Drug resistance of FLT3 mutants R-HSA-9702506
sorafenib-resistant FLT3 mutants R-HSA-9702624
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IRS-related events triggered by IGF1R R-HSA-2428928
FLT3 mutants bind TKIs R-HSA-9702509
IRS-mediated signalling R-HSA-112399
pexidartinib-resistant FLT3 mutants R-HSA-9702605
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
quizartinib-resistant FLT3 mutants R-HSA-9702620
semaxanib-resistant FLT3 mutants R-HSA-9702577
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
gilteritinib-resistant FLT3 mutants R-HSA-9702590
MAPK family signaling cascades R-HSA-5683057
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Negative regulation of the PI3K/AKT network R-HSA-199418
Cytokine Signaling in Immune system R-HSA-1280215
FLT3 signaling by CBL mutants R-HSA-9706377
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
sunitinib-resistant FLT3 mutants R-HSA-9702632
STAT5 Activation R-HSA-9645135
tamatinib-resistant FLT3 mutants R-HSA-9703009
IGF1R signaling cascade R-HSA-2428924
Insulin receptor signalling cascade R-HSA-74751
ponatinib-resistant FLT3 mutants R-HSA-9702614
Signal Transduction R-HSA-162582
PI3K Cascade R-HSA-109704
linifanib-resistant FLT3 mutants R-HSA-9702998
tandutinib-resistant FLT3 mutants R-HSA-9702636
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PIP3 activates AKT signaling R-HSA-1257604
KW2449-resistant FLT3 mutants R-HSA-9702569
FLT3 signaling in disease R-HSA-9682385
crenolanib-resistant FLT3 mutants R-HSA-9702581
Disease R-HSA-1643685
lestaurtinib-resistant FLT3 mutants R-HSA-9702596

Expression Atlas ENSG00000122025
LRG display in Ensembl gene LRG_457
NCBI gene (formerly Entrezgene) 2322
GeneCards 3765
HGNC Symbol HGNC:3765
MIM gene 136351
MIM morbid 613065
UniProtKB Gene Name P36888
WikiGene 2322
Gene: PTPN11
Ensembl ID : ENSG00000179295
Description: protein tyrosine phosphatase non-receptor type 11
Gene Synonyms: BPTP3,NS1,PTP2C,SH-PTP2,SHP-2,SHP2
1 APIs:
209 Possible Orthologues:

MET activates PTPN11 R-HSA-8865999
IRS-related events triggered by IGF1R R-HSA-2428928
GAB1 signalosome R-HSA-180292
Signaling by FGFR1 R-HSA-5654736
PIP3 activates AKT signaling R-HSA-1257604
Downstream signaling of activated FGFR3 R-HSA-5654708
FRS-mediated FGFR4 signaling R-HSA-5654712
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MyD88-independent TLR4 cascade R-HSA-166166
Signal regulatory protein family interactions R-HSA-391160
Nervous system development R-HSA-9675108
Interleukin-1 family signaling R-HSA-446652
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Cell-Cell communication R-HSA-1500931
Hemostasis R-HSA-109582
Prolactin receptor signaling R-HSA-1170546
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by PDGF R-HSA-186797
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Signaling by EGFR R-HSA-177929
Signaling by FGFR1 R-HSA-5654736
FRS-mediated FGFR3 signaling R-HSA-5654706
Interleukin-20 family signaling R-HSA-8854691
PECAM1 interactions R-HSA-210990
IGF1R signaling cascade R-HSA-2428924
Signaling by CSF3 (G-CSF) R-HSA-9674555
MAPK1/MAPK3 signaling R-HSA-5684996
Infectious disease R-HSA-5663205
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
MET activates PTPN11 R-HSA-8865999
Interleukin-37 signaling R-HSA-9008059
FLT3 signaling in disease R-HSA-9682385
Spry regulation of FGF signaling R-HSA-1295596
Interleukin-6 family signaling R-HSA-6783589
CTLA4 inhibitory signaling R-HSA-389513
Intracellular signaling by second messengers R-HSA-9006925
Gene expression (Transcription) R-HSA-74160
Interferon alpha/beta signaling R-HSA-909733
Interferon Signaling R-HSA-913531
Downstream signaling of activated FGFR1 R-HSA-5654687
Tie2 Signaling R-HSA-210993
Downstream signaling of activated FGFR4 R-HSA-5654716
Toll-like Receptor Cascades R-HSA-168898
Insulin receptor signalling cascade R-HSA-74751
IRS-mediated signalling R-HSA-112399
Interferon gamma signaling R-HSA-877300
PI3K Cascade R-HSA-109704
FLT3 Signaling R-HSA-9607240
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
MAPK1 (ERK2) activation R-HSA-112411
Platelet activation, signaling and aggregation R-HSA-76002
STAT5 Activation R-HSA-9645135
Interleukin-6 signaling R-HSA-1059683
Signaling by Interleukins R-HSA-449147
PD-1 signaling R-HSA-389948
Netrin-1 signaling R-HSA-373752
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
FRS-mediated FGFR1 signaling R-HSA-5654693
GPVI-mediated activation cascade R-HSA-114604
PI-3K cascade:FGFR4 R-HSA-5654720
PI-3K cascade:FGFR2 R-HSA-5654695
Negative regulation of FGFR2 signaling R-HSA-5654727
Signal Transduction R-HSA-162582
Regulation of IFNG signaling R-HSA-877312
Signaling by Insulin receptor R-HSA-74752
Downstream signaling of activated FGFR2 R-HSA-5654696
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by FGFR3 R-HSA-5654741
Transcriptional regulation by RUNX1 R-HSA-8878171
Netrin mediated repulsion signals R-HSA-418886
FRS-mediated FGFR2 signaling R-HSA-5654700
MAPK3 (ERK1) activation R-HSA-110056
RAF-independent MAPK1/3 activation R-HSA-112409
GAB1 signalosome R-HSA-180292
Negative regulation of FGFR1 signaling R-HSA-5654726
Innate Immune System R-HSA-168249
Signaling by NTRK2 (TRKB) R-HSA-9006115
Developmental Biology R-HSA-1266738
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Immune System R-HSA-168256
PI-3K cascade:FGFR3 R-HSA-5654710
Adaptive Immune System R-HSA-1280218
Signaling by FGFR4 R-HSA-5654743
RET signaling R-HSA-8853659
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Costimulation by the CD28 family R-HSA-388841
Cytokine Signaling in Immune system R-HSA-1280215
PI-3K cascade:FGFR1 R-HSA-5654689
Downstream signal transduction R-HSA-186763
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by MET R-HSA-6806834
Platelet homeostasis R-HSA-418346
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by SCF-KIT R-HSA-1433557
SARS-CoV-2 Infection R-HSA-9694516
Axon guidance R-HSA-422475
IRS-related events triggered by IGF1R R-HSA-2428928
Regulation of IFNA/IFNB signaling R-HSA-912694
Negative regulation of the PI3K/AKT network R-HSA-199418
Disease R-HSA-1643685
SARS-CoV Infections R-HSA-9679506
Platelet sensitization by LDL R-HSA-432142
Signaling by Leptin R-HSA-2586552
Signaling by FGFR2 R-HSA-5654738
SARS-CoV-2-host interactions R-HSA-9705683
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR R-HSA-190236
Signaling by NTRKs R-HSA-166520
Adaptive Immune System R-HSA-1280218
Downstream signaling of activated FGFR3 R-HSA-5654708
Axon guidance R-HSA-422475
Insulin receptor signalling cascade R-HSA-74751
Signaling by EGFR R-HSA-177929
Signal regulatory protein family interactions R-HSA-391160
Downstream signal transduction R-HSA-186763
IGF1R signaling cascade R-HSA-2428924
Developmental Biology R-HSA-1266738
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
GAB1 signalosome R-HSA-180292
Infectious disease R-HSA-5663205
Toll-like Receptor Cascades R-HSA-168898
Nervous system development R-HSA-9675108
PI3K Cascade R-HSA-109704
Interleukin-6 family signaling R-HSA-6783589
Costimulation by the CD28 family R-HSA-388841
FLT3 Signaling R-HSA-9607240
Downstream signaling of activated FGFR2 R-HSA-5654696
Cell-Cell communication R-HSA-1500931
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Platelet homeostasis R-HSA-418346
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Interleukin-37 signaling R-HSA-9008059
Signaling by MET R-HSA-6806834
Netrin mediated repulsion signals R-HSA-418886
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR3 R-HSA-5654741
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
MAPK3 (ERK1) activation R-HSA-110056
Signaling by FGFR2 R-HSA-5654738
Disease R-HSA-1643685
Regulation of IFNA/IFNB signaling R-HSA-912694
Signaling by Interleukins R-HSA-449147
SARS-CoV-2-host interactions R-HSA-9705683
IRS-mediated signalling R-HSA-112399
STAT5 Activation R-HSA-9645135
Hemostasis R-HSA-109582
Netrin-1 signaling R-HSA-373752
Signaling by FGFR4 R-HSA-5654743
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by CSF3 (G-CSF) R-HSA-9674555
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by Leptin R-HSA-2586552
Interferon alpha/beta signaling R-HSA-909733
Signaling by PDGF R-HSA-186797
Intracellular signaling by second messengers R-HSA-9006925
FRS-mediated FGFR3 signaling R-HSA-5654706
PD-1 signaling R-HSA-389948
PI-3K cascade:FGFR3 R-HSA-5654710
PIP3 activates AKT signaling R-HSA-1257604
PI3K/AKT Signaling in Cancer R-HSA-2219528
SARS-CoV-2 Infection R-HSA-9694516
Signaling by SCF-KIT R-HSA-1433557
Platelet activation, signaling and aggregation R-HSA-76002
Cytokine Signaling in Immune system R-HSA-1280215
FRS-mediated FGFR1 signaling R-HSA-5654693
MyD88-independent TLR4 cascade R-HSA-166166
Generic Transcription Pathway R-HSA-212436
Platelet sensitization by LDL R-HSA-432142
PI-3K cascade:FGFR1 R-HSA-5654689
Negative regulation of FGFR4 signaling R-HSA-5654733
Tie2 Signaling R-HSA-210993
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Interleukin-20 family signaling R-HSA-8854691
Downstream signaling of activated FGFR1 R-HSA-5654687
RET signaling R-HSA-8853659
Negative regulation of FGFR1 signaling R-HSA-5654726
IRS-related events triggered by IGF1R R-HSA-2428928
Interferon gamma signaling R-HSA-877300
GPVI-mediated activation cascade R-HSA-114604
Cell surface interactions at the vascular wall R-HSA-202733
Regulation of IFNG signaling R-HSA-877312
Gene expression (Transcription) R-HSA-74160
MAPK1 (ERK2) activation R-HSA-112411
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Negative regulation of FGFR2 signaling R-HSA-5654727
MET activates PTPN11 R-HSA-8865999
Transcriptional regulation by RUNX1 R-HSA-8878171
CTLA4 inhibitory signaling R-HSA-389513
Signaling by NTRK2 (TRKB) R-HSA-9006115
Prolactin receptor signaling R-HSA-1170546
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
FRS-mediated FGFR4 signaling R-HSA-5654712
Spry regulation of FGF signaling R-HSA-1295596
Signaling by NTRKs R-HSA-166520
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Interleukin-6 signaling R-HSA-1059683
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR1 R-HSA-5654736
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Regulation of RUNX1 Expression and Activity R-HSA-8934593
MAPK family signaling cascades R-HSA-5683057
Interferon Signaling R-HSA-913531
SARS-CoV Infections R-HSA-9679506
Interleukin-1 family signaling R-HSA-446652
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by FGFR R-HSA-190236
Signaling by Insulin receptor R-HSA-74752
PECAM1 interactions R-HSA-210990
RAF-independent MAPK1/3 activation R-HSA-112409
RNA Polymerase II Transcription R-HSA-73857
FRS-mediated FGFR2 signaling R-HSA-5654700
FLT3 signaling in disease R-HSA-9682385
PI-3K cascade:FGFR2 R-HSA-5654695
PI-3K cascade:FGFR4 R-HSA-5654720
Netrin-1 signaling R-HSA-373752
Signaling by Insulin receptor R-HSA-74752
Signaling by MET R-HSA-6806834
Platelet sensitization by LDL R-HSA-432142
RET signaling R-HSA-8853659
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by FGFR1 R-HSA-5654736
Toll-like Receptor Cascades R-HSA-168898
Signaling by Interleukins R-HSA-449147
STAT5 Activation R-HSA-9645135
Transcriptional regulation by RUNX1 R-HSA-8878171
FLT3 Signaling R-HSA-9607240
Negative regulation of FGFR3 signaling R-HSA-5654732
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Intracellular signaling by second messengers R-HSA-9006925
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by FGFR3 R-HSA-5654741
Signal Transduction R-HSA-162582
FRS-mediated FGFR4 signaling R-HSA-5654712
IGF1R signaling cascade R-HSA-2428924
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
GAB1 signalosome R-HSA-180292
Interleukin-1 family signaling R-HSA-446652
Prolactin receptor signaling R-HSA-1170546
Signaling by SCF-KIT R-HSA-1433557
Signaling by EGFR R-HSA-177929
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Disease R-HSA-1643685
Signal regulatory protein family interactions R-HSA-391160
Hemostasis R-HSA-109582
Signaling by FGFR2 R-HSA-5654738
Innate Immune System R-HSA-168249
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by PDGF R-HSA-186797
Signaling by FGFR R-HSA-190236
FRS-mediated FGFR2 signaling R-HSA-5654700
Interferon gamma signaling R-HSA-877300
Netrin mediated repulsion signals R-HSA-418886
Cell surface interactions at the vascular wall R-HSA-202733
Cell-Cell communication R-HSA-1500931
Negative regulation of FGFR4 signaling R-HSA-5654733
Developmental Biology R-HSA-1266738
Signaling by CSF3 (G-CSF) R-HSA-9674555
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Downstream signaling of activated FGFR1 R-HSA-5654687
Cytokine Signaling in Immune system R-HSA-1280215
FLT3 signaling in disease R-HSA-9682385
Interleukin-20 family signaling R-HSA-8854691
PI-3K cascade:FGFR1 R-HSA-5654689
Interleukin-37 signaling R-HSA-9008059
Nervous system development R-HSA-9675108
Interferon alpha/beta signaling R-HSA-909733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Adaptive Immune System R-HSA-1280218
Infectious disease R-HSA-5663205
Interferon Signaling R-HSA-913531
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PD-1 signaling R-HSA-389948
Signaling by Leptin R-HSA-2586552
MAPK3 (ERK1) activation R-HSA-110056
Downstream signal transduction R-HSA-186763
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by NTRKs R-HSA-166520
MAPK family signaling cascades R-HSA-5683057
Axon guidance R-HSA-422475
Negative regulation of FGFR1 signaling R-HSA-5654726
MAPK1 (ERK2) activation R-HSA-112411
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR4 R-HSA-5654743
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
MAPK1/MAPK3 signaling R-HSA-5684996
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
Downstream signaling of activated FGFR2 R-HSA-5654696
SARS-CoV-2-host interactions R-HSA-9705683
PI-3K cascade:FGFR4 R-HSA-5654720
Regulation of IFNG signaling R-HSA-877312
PI-3K cascade:FGFR3 R-HSA-5654710
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K Cascade R-HSA-109704
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
SARS-CoV Infections R-HSA-9679506
Immune System R-HSA-168256
PI3K/AKT Signaling in Cancer R-HSA-2219528
RNA Polymerase II Transcription R-HSA-73857
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
CTLA4 inhibitory signaling R-HSA-389513
Spry regulation of FGF signaling R-HSA-1295596
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Regulation of IFNA/IFNB signaling R-HSA-912694
PECAM1 interactions R-HSA-210990
Platelet homeostasis R-HSA-418346
Platelet activation, signaling and aggregation R-HSA-76002
Costimulation by the CD28 family R-HSA-388841
Downstream signaling of activated FGFR3 R-HSA-5654708
FRS-mediated FGFR3 signaling R-HSA-5654706
Interleukin-6 family signaling R-HSA-6783589
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
GPVI-mediated activation cascade R-HSA-114604
RAF-independent MAPK1/3 activation R-HSA-112409
Downstream signaling of activated FGFR4 R-HSA-5654716
Tie2 Signaling R-HSA-210993
Interleukin-6 signaling R-HSA-1059683
FRS-mediated FGFR1 signaling R-HSA-5654693
SARS-CoV-2 Infection R-HSA-9694516
Insulin receptor signalling cascade R-HSA-74751
Costimulation by the CD28 family R-HSA-388841
Downstream signaling of activated FGFR1 R-HSA-5654687
PI-3K cascade:FGFR1 R-HSA-5654689
FRS-mediated FGFR2 signaling R-HSA-5654700
RET signaling R-HSA-8853659
Signal regulatory protein family interactions R-HSA-391160
Disease R-HSA-1643685
Axon guidance R-HSA-422475
Regulation of IFNG signaling R-HSA-877312
Negative regulation of FGFR3 signaling R-HSA-5654732
Infectious disease R-HSA-5663205
Interleukin-6 signaling R-HSA-1059683
SARS-CoV Infections R-HSA-9679506
FRS-mediated FGFR3 signaling R-HSA-5654706
FRS-mediated FGFR4 signaling R-HSA-5654712
Netrin-1 signaling R-HSA-373752
Interferon Signaling R-HSA-913531
SARS-CoV-2 Infection R-HSA-9694516
PD-1 signaling R-HSA-389948
Signaling by FGFR1 R-HSA-5654736
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by Leptin R-HSA-2586552
Interferon alpha/beta signaling R-HSA-909733
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signal Transduction R-HSA-162582
Downstream signaling of activated FGFR2 R-HSA-5654696
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR R-HSA-190236
Transcriptional regulation by RUNX1 R-HSA-8878171
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Developmental Biology R-HSA-1266738
Signaling by FGFR3 R-HSA-5654741
Negative regulation of the PI3K/AKT network R-HSA-199418
MAPK3 (ERK1) activation R-HSA-110056
Negative regulation of FGFR1 signaling R-HSA-5654726
IGF1R signaling cascade R-HSA-2428924
Cytokine Signaling in Immune system R-HSA-1280215
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by MET R-HSA-6806834
MAPK family signaling cascades R-HSA-5683057
Platelet sensitization by LDL R-HSA-432142
RNA Polymerase II Transcription R-HSA-73857
IRS-mediated signalling R-HSA-112399
PI-3K cascade:FGFR3 R-HSA-5654710
PECAM1 interactions R-HSA-210990
IRS-related events triggered by IGF1R R-HSA-2428928
FLT3 Signaling R-HSA-9607240
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by NTRK2 (TRKB) R-HSA-9006115
SARS-CoV-2-host interactions R-HSA-9705683
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
MET activates PTPN11 R-HSA-8865999
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
FLT3 signaling in disease R-HSA-9682385
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Adaptive Immune System R-HSA-1280218
Signaling by NTRKs R-HSA-166520
Gene expression (Transcription) R-HSA-74160
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Netrin mediated repulsion signals R-HSA-418886
Signaling by Insulin receptor R-HSA-74752
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Negative regulation of FGFR2 signaling R-HSA-5654727
Spry regulation of FGF signaling R-HSA-1295596
MyD88-independent TLR4 cascade R-HSA-166166
CTLA4 inhibitory signaling R-HSA-389513
GPVI-mediated activation cascade R-HSA-114604
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Negative regulation of FGFR4 signaling R-HSA-5654733
Nervous system development R-HSA-9675108
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by CSF3 (G-CSF) R-HSA-9674555
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Platelet homeostasis R-HSA-418346
Prolactin receptor signaling R-HSA-1170546
STAT5 Activation R-HSA-9645135
PI3K Cascade R-HSA-109704
Regulation of IFNA/IFNB signaling R-HSA-912694
Innate Immune System R-HSA-168249
Signaling by EGFR R-HSA-177929
Interleukin-37 signaling R-HSA-9008059
Interferon gamma signaling R-HSA-877300
Signaling by FGFR2 R-HSA-5654738
Interleukin-6 family signaling R-HSA-6783589
Signaling by Interleukins R-HSA-449147
Intracellular signaling by second messengers R-HSA-9006925
Immune System R-HSA-168256
MAPK1 (ERK2) activation R-HSA-112411
Signaling by SCF-KIT R-HSA-1433557
Toll-like Receptor Cascades R-HSA-168898
Downstream signal transduction R-HSA-186763
FRS-mediated FGFR1 signaling R-HSA-5654693
GAB1 signalosome R-HSA-180292
Tie2 Signaling R-HSA-210993
Generic Transcription Pathway R-HSA-212436
Interleukin-20 family signaling R-HSA-8854691
Cell-Cell communication R-HSA-1500931
Platelet activation, signaling and aggregation R-HSA-76002
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
PIP3 activates AKT signaling R-HSA-1257604
RAF-independent MAPK1/3 activation R-HSA-112409
Cell surface interactions at the vascular wall R-HSA-202733
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR4 R-HSA-5654743
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by PDGF R-HSA-186797
Interleukin-1 family signaling R-HSA-446652
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
PI-3K cascade:FGFR4 R-HSA-5654720
Hemostasis R-HSA-109582
IGF1R signaling cascade R-HSA-2428924
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by MET R-HSA-6806834
FRS-mediated FGFR3 signaling R-HSA-5654706
GPVI-mediated activation cascade R-HSA-114604
Axon guidance R-HSA-422475
Downstream signaling of activated FGFR1 R-HSA-5654687
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by FGFR2 R-HSA-5654738
Generic Transcription Pathway R-HSA-212436
Spry regulation of FGF signaling R-HSA-1295596
Netrin-1 signaling R-HSA-373752
Interferon gamma signaling R-HSA-877300
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Infectious disease R-HSA-5663205
Interleukin-37 signaling R-HSA-9008059
RET signaling R-HSA-8853659
Signaling by Leptin R-HSA-2586552
Platelet sensitization by LDL R-HSA-432142
Costimulation by the CD28 family R-HSA-388841
Downstream signal transduction R-HSA-186763
SARS-CoV-2 Infection R-HSA-9694516
Signaling by CSF3 (G-CSF) R-HSA-9674555
GAB1 signalosome R-HSA-180292
Signaling by NTRKs R-HSA-166520
Interleukin-1 family signaling R-HSA-446652
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
RNA Polymerase II Transcription R-HSA-73857
IRS-mediated signalling R-HSA-112399
Platelet homeostasis R-HSA-418346
Signaling by SCF-KIT R-HSA-1433557
Cytokine Signaling in Immune system R-HSA-1280215
Developmental Biology R-HSA-1266738
Negative regulation of FGFR2 signaling R-HSA-5654727
Interleukin-6 family signaling R-HSA-6783589
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by PDGF R-HSA-186797
MAPK1 (ERK2) activation R-HSA-112411
Signaling by FGFR4 R-HSA-5654743
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Gene expression (Transcription) R-HSA-74160
Interleukin-20 family signaling R-HSA-8854691
PIP3 activates AKT signaling R-HSA-1257604
Downstream signaling of activated FGFR2 R-HSA-5654696
Netrin mediated repulsion signals R-HSA-418886
Downstream signaling of activated FGFR4 R-HSA-5654716
SARS-CoV Infections R-HSA-9679506
PI3K Cascade R-HSA-109704
FRS-mediated FGFR2 signaling R-HSA-5654700
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR1 signaling R-HSA-5654693
FRS-mediated FGFR4 signaling R-HSA-5654712
Cell-Cell communication R-HSA-1500931
Transcriptional regulation by RUNX1 R-HSA-8878171
Prolactin receptor signaling R-HSA-1170546
Interferon Signaling R-HSA-913531
Toll-like Receptor Cascades R-HSA-168898
Interferon alpha/beta signaling R-HSA-909733
Adaptive Immune System R-HSA-1280218
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR3 R-HSA-5654741
Tie2 Signaling R-HSA-210993
Disease R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Regulation of RUNX1 Expression and Activity R-HSA-8934593
MET activates PTPN11 R-HSA-8865999
Signaling by Insulin receptor R-HSA-74752
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
MyD88-independent TLR4 cascade R-HSA-166166
PI-3K cascade:FGFR4 R-HSA-5654720
Regulation of IFNG signaling R-HSA-877312
Interleukin-6 signaling R-HSA-1059683
Signal Transduction R-HSA-162582
Signaling by NTRK2 (TRKB) R-HSA-9006115
Cell surface interactions at the vascular wall R-HSA-202733
Insulin receptor signalling cascade R-HSA-74751
Hemostasis R-HSA-109582
SARS-CoV-2-host interactions R-HSA-9705683
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Nervous system development R-HSA-9675108
Innate Immune System R-HSA-168249
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K/AKT Signaling in Cancer R-HSA-2219528
Platelet activation, signaling and aggregation R-HSA-76002
STAT5 Activation R-HSA-9645135
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by EGFR R-HSA-177929
PD-1 signaling R-HSA-389948
Regulation of IFNA/IFNB signaling R-HSA-912694
Signaling by FGFR1 R-HSA-5654736
Signal regulatory protein family interactions R-HSA-391160
MAPK family signaling cascades R-HSA-5683057
PI-3K cascade:FGFR1 R-HSA-5654689
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR4 signaling R-HSA-5654733
Immune System R-HSA-168256
MAPK3 (ERK1) activation R-HSA-110056
Intracellular signaling by second messengers R-HSA-9006925
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
CTLA4 inhibitory signaling R-HSA-389513
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PECAM1 interactions R-HSA-210990
FLT3 signaling in disease R-HSA-9682385
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Interleukins R-HSA-449147
Signaling by FGFR3 R-HSA-5654741
Immune System R-HSA-168256
STAT5 Activation R-HSA-9645135
MAPK family signaling cascades R-HSA-5683057
RET signaling R-HSA-8853659
IRS-related events triggered by IGF1R R-HSA-2428928
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by EGFR R-HSA-177929
MAPK1 (ERK2) activation R-HSA-112411
CTLA4 inhibitory signaling R-HSA-389513
Signaling by PDGF R-HSA-186797
Signaling by CSF3 (G-CSF) R-HSA-9674555
Innate Immune System R-HSA-168249
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Hemostasis R-HSA-109582
Intracellular signaling by second messengers R-HSA-9006925
GPVI-mediated activation cascade R-HSA-114604
Platelet activation, signaling and aggregation R-HSA-76002
MAPK3 (ERK1) activation R-HSA-110056
Negative regulation of FGFR4 signaling R-HSA-5654733
FRS-mediated FGFR4 signaling R-HSA-5654712
Interleukin-6 signaling R-HSA-1059683
Cell surface interactions at the vascular wall R-HSA-202733
Interleukin-1 family signaling R-HSA-446652
Interferon Signaling R-HSA-913531
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Regulation of RUNX1 Expression and Activity R-HSA-8934593
IGF1R signaling cascade R-HSA-2428924
Interferon gamma signaling R-HSA-877300
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K Cascade R-HSA-109704
PI3K/AKT Signaling in Cancer R-HSA-2219528
Toll-like Receptor Cascades R-HSA-168898
Downstream signaling of activated FGFR3 R-HSA-5654708
Downstream signaling of activated FGFR4 R-HSA-5654716
Prolactin receptor signaling R-HSA-1170546
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR R-HSA-190236
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Adaptive Immune System R-HSA-1280218
Signaling by NTRK2 (TRKB) R-HSA-9006115
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by MET R-HSA-6806834
Signaling by Leptin R-HSA-2586552
Platelet homeostasis R-HSA-418346
Signaling by FGFR1 R-HSA-5654736
Netrin mediated repulsion signals R-HSA-418886
Signal regulatory protein family interactions R-HSA-391160
PI-3K cascade:FGFR2 R-HSA-5654695
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by Insulin receptor R-HSA-74752
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Platelet sensitization by LDL R-HSA-432142
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SARS-CoV Infections R-HSA-9679506
Downstream signal transduction R-HSA-186763
Signaling by SCF-KIT R-HSA-1433557
RNA Polymerase II Transcription R-HSA-73857
Nervous system development R-HSA-9675108
Infectious disease R-HSA-5663205
PI-3K cascade:FGFR4 R-HSA-5654720
SARS-CoV-2 Infection R-HSA-9694516
Transcriptional regulation by RUNX1 R-HSA-8878171
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR1 signaling R-HSA-5654693
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
PECAM1 interactions R-HSA-210990
Developmental Biology R-HSA-1266738
MyD88-independent TLR4 cascade R-HSA-166166
FRS-mediated FGFR3 signaling R-HSA-5654706
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Negative regulation of FGFR2 signaling R-HSA-5654727
Downstream signaling of activated FGFR2 R-HSA-5654696
Spry regulation of FGF signaling R-HSA-1295596
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
Signaling by FGFR2 R-HSA-5654738
MET activates PTPN11 R-HSA-8865999
PI-3K cascade:FGFR3 R-HSA-5654710
Interleukin-20 family signaling R-HSA-8854691
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
IRS-mediated signalling R-HSA-112399
RAF-independent MAPK1/3 activation R-HSA-112409
Costimulation by the CD28 family R-HSA-388841
Netrin-1 signaling R-HSA-373752
Cell-Cell communication R-HSA-1500931
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by FGFR4 R-HSA-5654743
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Axon guidance R-HSA-422475
Downstream signaling of activated FGFR1 R-HSA-5654687
Regulation of IFNG signaling R-HSA-877312
Tie2 Signaling R-HSA-210993
Interferon alpha/beta signaling R-HSA-909733
FLT3 signaling in disease R-HSA-9682385
Signal Transduction R-HSA-162582
PD-1 signaling R-HSA-389948
Interleukin-6 family signaling R-HSA-6783589
Interleukin-37 signaling R-HSA-9008059
Signaling by Interleukins R-HSA-449147
Negative regulation of FGFR3 signaling R-HSA-5654732
Generic Transcription Pathway R-HSA-212436
Regulation of IFNA/IFNB signaling R-HSA-912694
Insulin receptor signalling cascade R-HSA-74751
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
GPVI-mediated activation cascade R-HSA-114604
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by CSF3 (G-CSF) R-HSA-9674555
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FLT3 signaling in disease R-HSA-9682385
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional regulation by RUNX1 R-HSA-8878171
Interleukin-6 signaling R-HSA-1059683
Netrin-1 signaling R-HSA-373752
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Negative regulation of FGFR2 signaling R-HSA-5654727
Cell surface interactions at the vascular wall R-HSA-202733
Platelet homeostasis R-HSA-418346
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by FGFR4 R-HSA-5654743
RAF-independent MAPK1/3 activation R-HSA-112409
Regulation of IFNA/IFNB signaling R-HSA-912694
Developmental Biology R-HSA-1266738
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by PDGF R-HSA-186797
Interleukin-6 family signaling R-HSA-6783589
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Hemostasis R-HSA-109582
Interferon Signaling R-HSA-913531
Adaptive Immune System R-HSA-1280218
Downstream signaling of activated FGFR3 R-HSA-5654708
PI-3K cascade:FGFR3 R-HSA-5654710
Infectious disease R-HSA-5663205
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Nervous system development R-HSA-9675108
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
SARS-CoV-2 Infection R-HSA-9694516
Tie2 Signaling R-HSA-210993
MAPK1 (ERK2) activation R-HSA-112411
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by FGFR R-HSA-190236
Interferon gamma signaling R-HSA-877300
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Interleukin-20 family signaling R-HSA-8854691
Signaling by NTRKs R-HSA-166520
MET activates PTPN11 R-HSA-8865999
Cell-Cell communication R-HSA-1500931
IGF1R signaling cascade R-HSA-2428924
Signaling by FGFR2 R-HSA-5654738
Downstream signaling of activated FGFR2 R-HSA-5654696
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
MyD88-independent TLR4 cascade R-HSA-166166
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Interleukin-1 family signaling R-HSA-446652
Interleukin-37 signaling R-HSA-9008059
IRS-related events triggered by IGF1R R-HSA-2428928
PI-3K cascade:FGFR1 R-HSA-5654689
Generic Transcription Pathway R-HSA-212436
Signaling by EGFR R-HSA-177929
Interferon alpha/beta signaling R-HSA-909733
FRS-mediated FGFR4 signaling R-HSA-5654712
Axon guidance R-HSA-422475
PECAM1 interactions R-HSA-210990
Intracellular signaling by second messengers R-HSA-9006925
Signaling by Insulin receptor R-HSA-74752
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Immune System R-HSA-168256
PI-3K cascade:FGFR4 R-HSA-5654720
Insulin receptor signalling cascade R-HSA-74751
PI3K/AKT Signaling in Cancer R-HSA-2219528
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
FLT3 Signaling R-HSA-9607240
RET signaling R-HSA-8853659
MAPK family signaling cascades R-HSA-5683057
Toll-like Receptor Cascades R-HSA-168898
Regulation of IFNG signaling R-HSA-877312
Signaling by FGFR1 R-HSA-5654736
Costimulation by the CD28 family R-HSA-388841
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PIP3 activates AKT signaling R-HSA-1257604
MAPK3 (ERK1) activation R-HSA-110056
Regulation of RUNX1 Expression and Activity R-HSA-8934593
FRS-mediated FGFR3 signaling R-HSA-5654706
IRS-mediated signalling R-HSA-112399
PD-1 signaling R-HSA-389948
Signal regulatory protein family interactions R-HSA-391160
STAT5 Activation R-HSA-9645135
Prolactin receptor signaling R-HSA-1170546
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Downstream signal transduction R-HSA-186763
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR3 signaling R-HSA-5654732
PI-3K cascade:FGFR2 R-HSA-5654695
Netrin mediated repulsion signals R-HSA-418886
Innate Immune System R-HSA-168249
PI3K Cascade R-HSA-109704
Platelet sensitization by LDL R-HSA-432142
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by Leptin R-HSA-2586552
Spry regulation of FGF signaling R-HSA-1295596
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by Interleukins R-HSA-449147
Platelet activation, signaling and aggregation R-HSA-76002
Downstream signaling of activated FGFR1 R-HSA-5654687
FRS-mediated FGFR1 signaling R-HSA-5654693
GAB1 signalosome R-HSA-180292
MAPK1/MAPK3 signaling R-HSA-5684996
CTLA4 inhibitory signaling R-HSA-389513
Signaling by MET R-HSA-6806834
Signaling by SCF-KIT R-HSA-1433557
SARS-CoV Infections R-HSA-9679506
Signaling by FGFR3 R-HSA-5654741
Interleukin-37 signaling R-HSA-9008059
PI-3K cascade:FGFR1 R-HSA-5654689
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
MAPK family signaling cascades R-HSA-5683057
Interleukin-6 signaling R-HSA-1059683
Transcriptional regulation by RUNX1 R-HSA-8878171
Toll-like Receptor Cascades R-HSA-168898
Insulin receptor signalling cascade R-HSA-74751
Signaling by SCF-KIT R-HSA-1433557
Infectious disease R-HSA-5663205
Gene expression (Transcription) R-HSA-74160
Nervous system development R-HSA-9675108
SARS-CoV Infections R-HSA-9679506
FLT3 Signaling R-HSA-9607240
Cell-Cell communication R-HSA-1500931
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signal regulatory protein family interactions R-HSA-391160
Disease R-HSA-1643685
Downstream signal transduction R-HSA-186763
STAT5 Activation R-HSA-9645135
Signaling by Interleukins R-HSA-449147
Signaling by FGFR2 R-HSA-5654738
PI-3K cascade:FGFR4 R-HSA-5654720
MAPK3 (ERK1) activation R-HSA-110056
Immune System R-HSA-168256
Signaling by EGFR R-HSA-177929
Interferon gamma signaling R-HSA-877300
Interferon Signaling R-HSA-913531
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by Leptin R-HSA-2586552
Interleukin-6 family signaling R-HSA-6783589
Signaling by MET R-HSA-6806834
PI3K Cascade R-HSA-109704
FLT3 signaling in disease R-HSA-9682385
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
MAPK1/MAPK3 signaling R-HSA-5684996
PD-1 signaling R-HSA-389948
Signaling by Insulin receptor R-HSA-74752
Interferon alpha/beta signaling R-HSA-909733
Signaling by NTRKs R-HSA-166520
Innate Immune System R-HSA-168249
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Downstream signaling of activated FGFR4 R-HSA-5654716
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by CSF3 (G-CSF) R-HSA-9674555
Developmental Biology R-HSA-1266738
GPVI-mediated activation cascade R-HSA-114604
RET signaling R-HSA-8853659
Platelet sensitization by LDL R-HSA-432142
Netrin mediated repulsion signals R-HSA-418886
GAB1 signalosome R-HSA-180292
PECAM1 interactions R-HSA-210990
RNA Polymerase II Transcription R-HSA-73857
Interleukin-1 family signaling R-HSA-446652
PIP3 activates AKT signaling R-HSA-1257604
Regulation of IFNG signaling R-HSA-877312
Axon guidance R-HSA-422475
Regulation of IFNA/IFNB signaling R-HSA-912694
Interleukin-20 family signaling R-HSA-8854691
Negative regulation of the PI3K/AKT network R-HSA-199418
Negative regulation of FGFR1 signaling R-HSA-5654726
MAPK1 (ERK2) activation R-HSA-112411
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Adaptive Immune System R-HSA-1280218
IRS-related events triggered by IGF1R R-HSA-2428928
MET activates PTPN11 R-HSA-8865999
Signaling by FGFR3 R-HSA-5654741
Signaling by PDGF R-HSA-186797
Negative regulation of FGFR4 signaling R-HSA-5654733
CTLA4 inhibitory signaling R-HSA-389513
FRS-mediated FGFR4 signaling R-HSA-5654712
RAF-independent MAPK1/3 activation R-HSA-112409
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Signaling by FGFR R-HSA-190236
FRS-mediated FGFR2 signaling R-HSA-5654700
IRS-mediated signalling R-HSA-112399
Netrin-1 signaling R-HSA-373752
PI3K/AKT Signaling in Cancer R-HSA-2219528
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Platelet homeostasis R-HSA-418346
PI-3K cascade:FGFR3 R-HSA-5654710
Hemostasis R-HSA-109582
IGF1R signaling cascade R-HSA-2428924
FRS-mediated FGFR1 signaling R-HSA-5654693
Costimulation by the CD28 family R-HSA-388841
Negative regulation of FGFR3 signaling R-HSA-5654732
Negative regulation of FGFR2 signaling R-HSA-5654727
Platelet activation, signaling and aggregation R-HSA-76002
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR3 R-HSA-5654708
Spry regulation of FGF signaling R-HSA-1295596
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Generic Transcription Pathway R-HSA-212436
Downstream signaling of activated FGFR2 R-HSA-5654696
Signal Transduction R-HSA-162582
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Tie2 Signaling R-HSA-210993
SARS-CoV-2 Infection R-HSA-9694516
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR4 R-HSA-5654743
Cell surface interactions at the vascular wall R-HSA-202733
Prolactin receptor signaling R-HSA-1170546
PI-3K cascade:FGFR2 R-HSA-5654695
Intracellular signaling by second messengers R-HSA-9006925
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NTRK2 (TRKB) R-HSA-9006115
Platelet homeostasis R-HSA-418346
Signaling by Insulin receptor R-HSA-74752
Platelet activation, signaling and aggregation R-HSA-76002
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
PIP3 activates AKT signaling R-HSA-1257604
RET signaling R-HSA-8853659
STAT5 Activation R-HSA-9645135
PI3K/AKT Signaling in Cancer R-HSA-2219528
Interleukin-37 signaling R-HSA-9008059
PI-3K cascade:FGFR3 R-HSA-5654710
Interleukin-1 family signaling R-HSA-446652
Netrin-1 signaling R-HSA-373752
FRS-mediated FGFR4 signaling R-HSA-5654712
MAPK family signaling cascades R-HSA-5683057
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Insulin receptor signalling cascade R-HSA-74751
Regulation of IFNG signaling R-HSA-877312
Signaling by Interleukins R-HSA-449147
Signaling by EGFR R-HSA-177929
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Regulation of RUNX1 Expression and Activity R-HSA-8934593
PI3K Cascade R-HSA-109704
Disease R-HSA-1643685
Prolactin receptor signaling R-HSA-1170546
MET activates PTPN11 R-HSA-8865999
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR3 signaling R-HSA-5654706
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by FGFR1 R-HSA-5654736
GAB1 signalosome R-HSA-180292
Costimulation by the CD28 family R-HSA-388841
Spry regulation of FGF signaling R-HSA-1295596
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Platelet sensitization by LDL R-HSA-432142
MAPK3 (ERK1) activation R-HSA-110056
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
Adaptive Immune System R-HSA-1280218
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Toll-like Receptor Cascades R-HSA-168898
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FRS-mediated FGFR2 signaling R-HSA-5654700
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Downstream signaling of activated FGFR2 R-HSA-5654696
RAF-independent MAPK1/3 activation R-HSA-112409
Negative regulation of FGFR4 signaling R-HSA-5654733
PI-3K cascade:FGFR4 R-HSA-5654720
Downstream signaling of activated FGFR3 R-HSA-5654708
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Intracellular signaling by second messengers R-HSA-9006925
PI-3K cascade:FGFR2 R-HSA-5654695
IGF1R signaling cascade R-HSA-2428924
Downstream signal transduction R-HSA-186763
Developmental Biology R-HSA-1266738
Infectious disease R-HSA-5663205
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Nervous system development R-HSA-9675108
Negative regulation of FGFR2 signaling R-HSA-5654727
SARS-CoV-2 Infection R-HSA-9694516
MyD88-independent TLR4 cascade R-HSA-166166
CTLA4 inhibitory signaling R-HSA-389513
Signaling by FGFR3 R-HSA-5654741
GPVI-mediated activation cascade R-HSA-114604
Gene expression (Transcription) R-HSA-74160
Negative regulation of the PI3K/AKT network R-HSA-199418
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Cytokine Signaling in Immune system R-HSA-1280215
Tie2 Signaling R-HSA-210993
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by PDGF R-HSA-186797
Signaling by FGFR2 R-HSA-5654738
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Transcriptional regulation by RUNX1 R-HSA-8878171
Signaling by Leptin R-HSA-2586552
Signaling by MET R-HSA-6806834
Interferon Signaling R-HSA-913531
Interferon alpha/beta signaling R-HSA-909733
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Interleukin-20 family signaling R-HSA-8854691
Regulation of IFNA/IFNB signaling R-HSA-912694
Signal regulatory protein family interactions R-HSA-391160
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Generic Transcription Pathway R-HSA-212436
Hemostasis R-HSA-109582
Cell surface interactions at the vascular wall R-HSA-202733
SARS-CoV-2-host interactions R-HSA-9705683
PD-1 signaling R-HSA-389948
PI-3K cascade:FGFR1 R-HSA-5654689
RNA Polymerase II Transcription R-HSA-73857
PECAM1 interactions R-HSA-210990
Signaling by SCF-KIT R-HSA-1433557
Interleukin-6 family signaling R-HSA-6783589
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR R-HSA-190236
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR1 signaling R-HSA-5654726
SARS-CoV Infections R-HSA-9679506
Interleukin-6 signaling R-HSA-1059683
IRS-mediated signalling R-HSA-112399
Interferon gamma signaling R-HSA-877300
FLT3 signaling in disease R-HSA-9682385
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by CSF3 (G-CSF) R-HSA-9674555
Immune System R-HSA-168256
Signaling by FGFR4 R-HSA-5654743
Cell-Cell communication R-HSA-1500931
Netrin mediated repulsion signals R-HSA-418886
Innate Immune System R-HSA-168249
Prolactin receptor signaling R-HSA-1170546
Cell surface interactions at the vascular wall R-HSA-202733
FRS-mediated FGFR4 signaling R-HSA-5654712
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
PI3K/AKT Signaling in Cancer R-HSA-2219528
Immune System R-HSA-168256
PI3K Cascade R-HSA-109704
Signal Transduction R-HSA-162582
MyD88-independent TLR4 cascade R-HSA-166166
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR1 R-HSA-5654736
MAPK1 (ERK2) activation R-HSA-112411
PD-1 signaling R-HSA-389948
Downstream signal transduction R-HSA-186763
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by CSF3 (G-CSF) R-HSA-9674555
Axon guidance R-HSA-422475
Infectious disease R-HSA-5663205
Netrin mediated repulsion signals R-HSA-418886
Signaling by FGFR3 R-HSA-5654741
Generic Transcription Pathway R-HSA-212436
Interleukin-6 signaling R-HSA-1059683
Platelet activation, signaling and aggregation R-HSA-76002
FLT3 Signaling R-HSA-9607240
Signaling by FGFR R-HSA-190236
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by NTRKs R-HSA-166520
SARS-CoV-2-host interactions R-HSA-9705683
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PI-3K cascade:FGFR1 R-HSA-5654689
Transcriptional regulation by RUNX1 R-HSA-8878171
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Tie2 Signaling R-HSA-210993
GAB1 signalosome R-HSA-180292
PI-3K cascade:FGFR2 R-HSA-5654695
FLT3 signaling in disease R-HSA-9682385
Signaling by SCF-KIT R-HSA-1433557
Insulin receptor signalling cascade R-HSA-74751
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR R-HSA-177929
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by FGFR4 R-HSA-5654743
Innate Immune System R-HSA-168249
MET activates PTPN11 R-HSA-8865999
Adaptive Immune System R-HSA-1280218
IRS-mediated signalling R-HSA-112399
Interferon alpha/beta signaling R-HSA-909733
Nervous system development R-HSA-9675108
Intracellular signaling by second messengers R-HSA-9006925
Downstream signaling of activated FGFR3 R-HSA-5654708
Platelet homeostasis R-HSA-418346
GPVI-mediated activation cascade R-HSA-114604
Interferon Signaling R-HSA-913531
Signaling by MET R-HSA-6806834
Gene expression (Transcription) R-HSA-74160
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal regulatory protein family interactions R-HSA-391160
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
SARS-CoV Infections R-HSA-9679506
Cell-Cell communication R-HSA-1500931
CTLA4 inhibitory signaling R-HSA-389513
Negative regulation of FGFR1 signaling R-HSA-5654726
Interferon gamma signaling R-HSA-877300
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Regulation of IFNG signaling R-HSA-877312
Interleukin-20 family signaling R-HSA-8854691
Negative regulation of FGFR3 signaling R-HSA-5654732
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
PECAM1 interactions R-HSA-210990
Costimulation by the CD28 family R-HSA-388841
Negative regulation of FGFR2 signaling R-HSA-5654727
IGF1R signaling cascade R-HSA-2428924
Cytokine Signaling in Immune system R-HSA-1280215
RAF-independent MAPK1/3 activation R-HSA-112409
MAPK3 (ERK1) activation R-HSA-110056
Downstream signaling of activated FGFR1 R-HSA-5654687
STAT5 Activation R-HSA-9645135
Disease R-HSA-1643685
RET signaling R-HSA-8853659
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-936964
Signaling by Interleukins R-HSA-449147
Toll-like Receptor Cascades R-HSA-168898
Signaling by Leptin R-HSA-2586552
PIP3 activates AKT signaling R-HSA-1257604
SARS-CoV-2 activates/modulates innate and adaptive immune responses R-HSA-9705671
Platelet sensitization by LDL R-HSA-432142
Regulation of IFNA/IFNB signaling R-HSA-912694
Hemostasis R-HSA-109582
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by FGFR2 R-HSA-5654738
Developmental Biology R-HSA-1266738
Interleukin-6 family signaling R-HSA-6783589
Signaling by Insulin receptor R-HSA-74752
FRS-mediated FGFR3 signaling R-HSA-5654706
Netrin-1 signaling R-HSA-373752
SARS-CoV-2 Infection R-HSA-9694516
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by NTRK2 (TRKB) R-HSA-9006115
Interleukin-37 signaling R-HSA-9008059
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by PDGF R-HSA-186797
Interleukin-1 family signaling R-HSA-446652
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR4 R-HSA-5654716
FRS-mediated FGFR2 signaling R-HSA-5654700
MAPK family signaling cascades R-HSA-5683057
PI-3K cascade:FGFR4 R-HSA-5654720

Expression Atlas ENSG00000179295
LRG display in Ensembl gene LRG_614
NCBI gene (formerly Entrezgene) 5781
GeneCards 9644
HGNC Symbol HGNC:9644
MIM gene 176876
MIM morbid 607785
UniProtKB Gene Name Q06124
WikiGene 5781
Gene: IMPDH2
Ensembl ID : ENSG00000178035
Description: inosine monophosphate dehydrogenase 2
Gene Synonyms:
6 APIs:
202 Possible Orthologues:

Potential therapeutics for SARS R-HSA-9679191
SARS-CoV Infections R-HSA-9679506
Metabolism of nucleotides R-HSA-15869
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Azathioprine ADME R-HSA-9748787
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Metabolism R-HSA-1430728
Drug ADME R-HSA-9748784
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
Nucleotide biosynthesis R-HSA-8956320
SARS-CoV Infections R-HSA-9679506
Metabolism of nucleotides R-HSA-15869
Potential therapeutics for SARS R-HSA-9679191
Disease R-HSA-1643685
Neutrophil degranulation R-HSA-6798695
Nucleotide biosynthesis R-HSA-8956320
Metabolism R-HSA-1430728
Immune System R-HSA-168256
Infectious disease R-HSA-5663205
Innate Immune System R-HSA-168249
Azathioprine ADME R-HSA-9748787
Drug ADME R-HSA-9748784
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Disease R-HSA-1643685
Infectious disease R-HSA-5663205
Metabolism R-HSA-1430728
Potential therapeutics for SARS R-HSA-9679191
Nucleotide biosynthesis R-HSA-8956320
SARS-CoV Infections R-HSA-9679506
Metabolism of nucleotides R-HSA-15869
Immune System R-HSA-168256
Azathioprine ADME R-HSA-9748787
Innate Immune System R-HSA-168249
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Neutrophil degranulation R-HSA-6798695
Drug ADME R-HSA-9748784
Innate Immune System R-HSA-168249
Potential therapeutics for SARS R-HSA-9679191
Neutrophil degranulation R-HSA-6798695
Metabolism R-HSA-1430728
Metabolism of nucleotides R-HSA-15869
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Disease R-HSA-1643685
Immune System R-HSA-168256
Drug ADME R-HSA-9748784
Infectious disease R-HSA-5663205
SARS-CoV Infections R-HSA-9679506
Nucleotide biosynthesis R-HSA-8956320
Azathioprine ADME R-HSA-9748787
Metabolism R-HSA-1430728
Innate Immune System R-HSA-168249
Drug ADME R-HSA-9748784
SARS-CoV Infections R-HSA-9679506
Metabolism of nucleotides R-HSA-15869
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Disease R-HSA-1643685
Infectious disease R-HSA-5663205
Azathioprine ADME R-HSA-9748787
Immune System R-HSA-168256
Potential therapeutics for SARS R-HSA-9679191
Nucleotide biosynthesis R-HSA-8956320
Neutrophil degranulation R-HSA-6798695
SARS-CoV Infections R-HSA-9679506
Azathioprine ADME R-HSA-9748787
Infectious disease R-HSA-5663205
Immune System R-HSA-168256
Nucleotide biosynthesis R-HSA-8956320
Potential therapeutics for SARS R-HSA-9679191
Metabolism of nucleotides R-HSA-15869
Metabolism R-HSA-1430728
Innate Immune System R-HSA-168249
Drug ADME R-HSA-9748784
Neutrophil degranulation R-HSA-6798695
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Disease R-HSA-1643685
Innate Immune System R-HSA-168249
Drug ADME R-HSA-9748784
Disease R-HSA-1643685
Nucleotide biosynthesis R-HSA-8956320
Potential therapeutics for SARS R-HSA-9679191
Infectious disease R-HSA-5663205
Metabolism of nucleotides R-HSA-15869
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Neutrophil degranulation R-HSA-6798695
Metabolism R-HSA-1430728
Immune System R-HSA-168256
Azathioprine ADME R-HSA-9748787
SARS-CoV Infections R-HSA-9679506
Potential therapeutics for SARS R-HSA-9679191
Drug ADME R-HSA-9748784
Innate Immune System R-HSA-168249
Disease R-HSA-1643685
Azathioprine ADME R-HSA-9748787
SARS-CoV Infections R-HSA-9679506
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Metabolism R-HSA-1430728
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Metabolism of nucleotides R-HSA-15869
Infectious disease R-HSA-5663205
Nucleotide biosynthesis R-HSA-8956320
Azathioprine ADME R-HSA-9748787
Nucleotide biosynthesis R-HSA-8956320
Innate Immune System R-HSA-168249
Potential therapeutics for SARS R-HSA-9679191
SARS-CoV Infections R-HSA-9679506
Disease R-HSA-1643685
Neutrophil degranulation R-HSA-6798695
Drug ADME R-HSA-9748784
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Metabolism R-HSA-1430728
Infectious disease R-HSA-5663205
Immune System R-HSA-168256
Metabolism of nucleotides R-HSA-15869
Infectious disease R-HSA-5663205
SARS-CoV Infections R-HSA-9679506
Nucleotide biosynthesis R-HSA-8956320
Disease R-HSA-1643685
Potential therapeutics for SARS R-HSA-9679191
Immune System R-HSA-168256
Metabolism of nucleotides R-HSA-15869
Drug ADME R-HSA-9748784
Purine ribonucleoside monophosphate biosynthesis R-HSA-73817
Neutrophil degranulation R-HSA-6798695
Metabolism R-HSA-1430728
Innate Immune System R-HSA-168249
Azathioprine ADME R-HSA-9748787

Expression Atlas ENSG00000178035
NCBI gene (formerly Entrezgene) 3615
GeneCards 6053
HGNC Symbol HGNC:6053
MIM gene 146691
MIM morbid 617995
UniProtKB Gene Name P12268
WikiGene 3615
Gene: TOP2A
Ensembl ID : ENSG00000131747
Description: DNA topoisomerase II alpha
Gene Synonyms: TOP2,TOP2ALPHA,TOPIIA
21 APIs:
206 Possible Orthologues:

Mitotic G1 phase and G1/S transition R-HSA-453279
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
SUMOylation R-HSA-2990846
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
SUMOylation of DNA replication proteins R-HSA-4615885
SUMOylation of DNA replication proteins R-HSA-4615885
Cell Cycle R-HSA-1640170
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
SUMOylation R-HSA-2990846
Mitotic G1 phase and G1/S transition R-HSA-453279
G0 and Early G1 R-HSA-1538133
Cell Cycle, Mitotic R-HSA-69278
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Metabolism of proteins R-HSA-392499
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SUMOylation of DNA replication proteins R-HSA-4615885
SUMOylation R-HSA-2990846
Mitotic G1 phase and G1/S transition R-HSA-453279
Metabolism of proteins R-HSA-392499
Cell Cycle, Mitotic R-HSA-69278
G0 and Early G1 R-HSA-1538133
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle R-HSA-1640170
SUMOylation R-HSA-2990846
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
SUMOylation of DNA replication proteins R-HSA-4615885
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Mitotic G1 phase and G1/S transition R-HSA-453279
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
Cell Cycle, Mitotic R-HSA-69278
Post-translational protein modification R-HSA-597592
Mitotic G1 phase and G1/S transition R-HSA-453279
SUMOylation R-HSA-2990846
SUMOylation of DNA replication proteins R-HSA-4615885
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle R-HSA-1640170
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Mitotic G1 phase and G1/S transition R-HSA-453279
Metabolism of proteins R-HSA-392499
Post-translational protein modification R-HSA-597592
SUMOylation of DNA replication proteins R-HSA-4615885
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
G0 and Early G1 R-HSA-1538133
SUMOylation R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SUMOylation R-HSA-2990846
Cell Cycle R-HSA-1640170
G0 and Early G1 R-HSA-1538133
Cell Cycle, Mitotic R-HSA-69278
SUMOylation of DNA replication proteins R-HSA-4615885
Mitotic G1 phase and G1/S transition R-HSA-453279
Metabolism of proteins R-HSA-392499
Metabolism of proteins R-HSA-392499
SUMOylation of DNA replication proteins R-HSA-4615885
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle, Mitotic R-HSA-69278
SUMOylation R-HSA-2990846
G0 and Early G1 R-HSA-1538133
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle R-HSA-1640170
SUMOylation of DNA replication proteins R-HSA-4615885
SUMOylation R-HSA-2990846
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
Mitotic G1 phase and G1/S transition R-HSA-453279
Post-translational protein modification R-HSA-597592
SUMOylation of DNA replication proteins R-HSA-4615885
Cell Cycle R-HSA-1640170
Metabolism of proteins R-HSA-392499
Mitotic G1 phase and G1/S transition R-HSA-453279
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle, Mitotic R-HSA-69278
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
G0 and Early G1 R-HSA-1538133
Post-translational protein modification R-HSA-597592
SUMOylation R-HSA-2990846

Expression Atlas ENSG00000131747
NCBI gene (formerly Entrezgene) 7153
GeneCards 11989
HGNC Symbol HGNC:11989
MIM gene 126430
UniProtKB Gene Name P11388
WikiGene 7153
Gene: BACE1
Ensembl ID : ENSG00000186318
Description: beta-secretase 1
Gene Synonyms: BACE
4 APIs:
220 Possible Orthologues:

Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225

Expression Atlas ENSG00000186318
NCBI gene (formerly Entrezgene) 23621
GeneCards 933
HGNC Symbol HGNC:933
MIM gene 604252
UniProtKB Gene Name U3KPS1
WikiGene 23621
Gene: AKT2
Ensembl ID : ENSG00000105221
Description: AKT serine/threonine kinase 2
Gene Synonyms: PKBB
14 APIs:
257 Possible Orthologues:

Cell Cycle R-HSA-1640170
Regulation of TP53 Expression and Degradation R-HSA-6806003
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
AKT-mediated inactivation of FOXO1A R-HSA-211163
Infectious disease R-HSA-5663205
Mitotic G1 phase and G1/S transition R-HSA-453279
Downregulation of ERBB2 signaling R-HSA-8863795
Immune System R-HSA-168256
Activation of BH3-only proteins R-HSA-114452
VEGFR2 mediated vascular permeability R-HSA-5218920
S Phase R-HSA-69242
Cellular responses to stress R-HSA-2262752
Signaling by ERBB2 R-HSA-1227986
Cyclin E associated events during G1/S transition R-HSA-69202
Generic Transcription Pathway R-HSA-212436
Programmed Cell Death R-HSA-5357801
AKT phosphorylates targets in the cytosol R-HSA-198323
Adaptive Immune System R-HSA-1280218
Regulation of PTEN stability and activity R-HSA-8948751
SARS-CoV-2 Infection R-HSA-9694516
GPCR downstream signalling R-HSA-388396
FLT3 Signaling R-HSA-9607240
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Intracellular signaling by second messengers R-HSA-9006925
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by GPCR R-HSA-372790
CTLA4 inhibitory signaling R-HSA-389513
Insulin receptor signalling cascade R-HSA-74751
PDE3B signalling R-HSA-165160
CD28 co-stimulation R-HSA-389356
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
IRS-related events triggered by IGF1R R-HSA-2428928
Regulation of TP53 Activity R-HSA-5633007
G-protein beta:gamma signalling R-HSA-397795
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Cell Cycle, Mitotic R-HSA-69278
TCF dependent signaling in response to WNT R-HSA-201681
Regulation of beta-cell development R-HSA-186712
Activation of BAD and translocation to mitochondria R-HSA-111447
CD28 dependent PI3K/Akt signaling R-HSA-389357
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Signaling by WNT R-HSA-195721
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
Membrane Trafficking R-HSA-199991
FOXO-mediated transcription R-HSA-9614085
KEAP1-NFE2L2 pathway R-HSA-9755511
Signaling by Nuclear Receptors R-HSA-9006931
SARS-CoV Infections R-HSA-9679506
Apoptosis R-HSA-109581
Disease R-HSA-1643685
TP53 Regulates Metabolic Genes R-HSA-5628897
Extra-nuclear estrogen signaling R-HSA-9009391
PI3K Cascade R-HSA-109704
Regulation of gene expression in beta cells R-HSA-210745
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by VEGF R-HSA-194138
Vesicle-mediated transport R-HSA-5653656
Negative regulation of the PI3K/AKT network R-HSA-199418
Regulation of localization of FOXO transcription factors R-HSA-9614399
Transcriptional Regulation by TP53 R-HSA-3700989
PIP3 activates AKT signaling R-HSA-1257604
Cytokine Signaling in Immune system R-HSA-1280215
AKT phosphorylates targets in the nucleus R-HSA-198693
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
Signal Transduction R-HSA-162582
PTEN Regulation R-HSA-6807070
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Cellular responses to stimuli R-HSA-8953897
Activation of AKT2 R-HSA-165158
Developmental Biology R-HSA-1266738
SARS-CoV-2-host interactions R-HSA-9705683
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Signaling by Insulin receptor R-HSA-74752
Costimulation by the CD28 family R-HSA-388841
Inhibition of TSC complex formation by PKB R-HSA-165181
RNA Polymerase II Transcription R-HSA-73857
PKB-mediated events R-HSA-109703
Regulation of TP53 Degradation R-HSA-6804757
MTOR signalling R-HSA-165159
Rab regulation of trafficking R-HSA-9007101
IGF1R signaling cascade R-HSA-2428924
Transcriptional regulation by RUNX2 R-HSA-8878166
Gene expression (Transcription) R-HSA-74160
Cellular response to chemical stress R-HSA-9711123
ESR-mediated signaling R-HSA-8939211
G1/S Transition R-HSA-69206
IRS-mediated signalling R-HSA-112399
VEGFA-VEGFR2 Pathway R-HSA-4420097
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by Nuclear Receptors R-HSA-9006931
Regulation of beta-cell development R-HSA-186712
Signal Transduction R-HSA-162582
IRS-mediated signalling R-HSA-112399
Activation of BH3-only proteins R-HSA-114452
MTOR signalling R-HSA-165159
Cell Cycle, Mitotic R-HSA-69278
Cellular responses to stimuli R-HSA-8953897
Intracellular signaling by second messengers R-HSA-9006925
G1/S Transition R-HSA-69206
Immune System R-HSA-168256
Apoptosis R-HSA-109581
PI3K Cascade R-HSA-109704
Regulation of TP53 Degradation R-HSA-6804757
G-protein beta:gamma signalling R-HSA-397795
Signaling by VEGF R-HSA-194138
ESR-mediated signaling R-HSA-8939211
Regulation of TP53 Expression and Degradation R-HSA-6806003
Costimulation by the CD28 family R-HSA-388841
SARS-CoV Infections R-HSA-9679506
Extra-nuclear estrogen signaling R-HSA-9009391
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Signaling by GPCR R-HSA-372790
CD28 dependent PI3K/Akt signaling R-HSA-389357
Disease R-HSA-1643685
VEGFA-VEGFR2 Pathway R-HSA-4420097
Mitotic G1 phase and G1/S transition R-HSA-453279
IRS-related events triggered by IGF1R R-HSA-2428928
IGF1R signaling cascade R-HSA-2428924
FLT3 Signaling R-HSA-9607240
Cell Cycle R-HSA-1640170
Activation of AKT2 R-HSA-165158
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
PIP3 activates AKT signaling R-HSA-1257604
KEAP1-NFE2L2 pathway R-HSA-9755511
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
CD28 co-stimulation R-HSA-389356
AKT phosphorylates targets in the cytosol R-HSA-198323
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
TP53 Regulates Metabolic Genes R-HSA-5628897
Adaptive Immune System R-HSA-1280218
PDE3B signalling R-HSA-165160
SARS-CoV-2 Infection R-HSA-9694516
Infectious disease R-HSA-5663205
Cyclin E associated events during G1/S transition R-HSA-69202
PTEN Regulation R-HSA-6807070
Signaling by Insulin receptor R-HSA-74752
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Cytokine Signaling in Immune system R-HSA-1280215
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by ERBB2 R-HSA-1227986
Developmental Biology R-HSA-1266738
VEGFR2 mediated vascular permeability R-HSA-5218920
Rab regulation of trafficking R-HSA-9007101
PI3K/AKT Signaling in Cancer R-HSA-2219528
Regulation of TP53 Activity R-HSA-5633007
Downregulation of ERBB2 signaling R-HSA-8863795
PKB-mediated events R-HSA-109703
Regulation of localization of FOXO transcription factors R-HSA-9614399
Insulin receptor signalling cascade R-HSA-74751
RNA Polymerase II Transcription R-HSA-73857
Signaling by WNT R-HSA-195721
Vesicle-mediated transport R-HSA-5653656
AKT phosphorylates targets in the nucleus R-HSA-198693
Negative regulation of the PI3K/AKT network R-HSA-199418
GPCR downstream signalling R-HSA-388396
Gene expression (Transcription) R-HSA-74160
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Regulation of PTEN stability and activity R-HSA-8948751
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
S Phase R-HSA-69242
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Programmed Cell Death R-HSA-5357801
AKT-mediated inactivation of FOXO1A R-HSA-211163
Membrane Trafficking R-HSA-199991
Inhibition of TSC complex formation by PKB R-HSA-165181
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cellular responses to stress R-HSA-2262752
SARS-CoV-2-host interactions R-HSA-9705683
Transcriptional regulation by RUNX2 R-HSA-8878166
Regulation of gene expression in beta cells R-HSA-210745
Generic Transcription Pathway R-HSA-212436
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
Activation of BAD and translocation to mitochondria R-HSA-111447
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
FOXO-mediated transcription R-HSA-9614085
Cellular response to chemical stress R-HSA-9711123
CTLA4 inhibitory signaling R-HSA-389513
TCF dependent signaling in response to WNT R-HSA-201681
Membrane Trafficking R-HSA-199991
Cell Cycle, Mitotic R-HSA-69278
Signaling by ERBB2 R-HSA-1227986
Cyclin E associated events during G1/S transition R-HSA-69202
Extra-nuclear estrogen signaling R-HSA-9009391
Generic Transcription Pathway R-HSA-212436
Signal Transduction R-HSA-162582
G-protein beta:gamma signalling R-HSA-397795
AKT-mediated inactivation of FOXO1A R-HSA-211163
IRS-mediated signalling R-HSA-112399
PI3K/AKT Signaling in Cancer R-HSA-2219528
SARS-CoV-2-host interactions R-HSA-9705683
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
KEAP1-NFE2L2 pathway R-HSA-9755511
Signaling by Insulin receptor R-HSA-74752
G beta:gamma signalling through PI3Kgamma R-HSA-392451
CTLA4 inhibitory signaling R-HSA-389513
Signaling by WNT R-HSA-195721
Intracellular signaling by second messengers R-HSA-9006925
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
TCF dependent signaling in response to WNT R-HSA-201681
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
FOXO-mediated transcription R-HSA-9614085
Transcriptional Regulation by TP53 R-HSA-3700989
Cellular response to chemical stress R-HSA-9711123
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
TP53 Regulates Metabolic Genes R-HSA-5628897
PI3K Cascade R-HSA-109704
Regulation of gene expression in beta cells R-HSA-210745
Vesicle-mediated transport R-HSA-5653656
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Downregulation of ERBB2 signaling R-HSA-8863795
Apoptosis R-HSA-109581
Cellular responses to stress R-HSA-2262752
Disease R-HSA-1643685
SARS-CoV-2 Infection R-HSA-9694516
Activation of AKT2 R-HSA-165158
Signaling by VEGF R-HSA-194138
Rab regulation of trafficking R-HSA-9007101
Intrinsic Pathway for Apoptosis R-HSA-109606
PKB-mediated events R-HSA-109703
IGF1R signaling cascade R-HSA-2428924
Cellular responses to stimuli R-HSA-8953897
VEGFA-VEGFR2 Pathway R-HSA-4420097
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Negative regulation of the PI3K/AKT network R-HSA-199418
Cytokine Signaling in Immune system R-HSA-1280215
MTOR signalling R-HSA-165159
Regulation of TP53 Activity through Acetylation R-HSA-6804758
IRS-related events triggered by IGF1R R-HSA-2428928
Costimulation by the CD28 family R-HSA-388841
G1/S Transition R-HSA-69206
Regulation of TP53 Degradation R-HSA-6804757
Immune System R-HSA-168256
Developmental Biology R-HSA-1266738
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Gene expression (Transcription) R-HSA-74160
Activation of BH3-only proteins R-HSA-114452
Signaling by GPCR R-HSA-372790
Regulation of PTEN stability and activity R-HSA-8948751
AKT phosphorylates targets in the nucleus R-HSA-198693
VEGFR2 mediated vascular permeability R-HSA-5218920
SARS-CoV Infections R-HSA-9679506
Cell Cycle R-HSA-1640170
Inhibition of TSC complex formation by PKB R-HSA-165181
GPCR downstream signalling R-HSA-388396
Programmed Cell Death R-HSA-5357801
FLT3 Signaling R-HSA-9607240
Adaptive Immune System R-HSA-1280218
CD28 dependent PI3K/Akt signaling R-HSA-389357
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
Regulation of TP53 Expression and Degradation R-HSA-6806003
AKT phosphorylates targets in the cytosol R-HSA-198323
PTEN Regulation R-HSA-6807070
Infectious disease R-HSA-5663205
Regulation of localization of FOXO transcription factors R-HSA-9614399
RNA Polymerase II Transcription R-HSA-73857
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Activity R-HSA-5633007
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
Transcriptional regulation by RUNX2 R-HSA-8878166
S Phase R-HSA-69242
Regulation of beta-cell development R-HSA-186712
Signaling by Nuclear Receptors R-HSA-9006931
Insulin receptor signalling cascade R-HSA-74751
CD28 co-stimulation R-HSA-389356
PDE3B signalling R-HSA-165160
ESR-mediated signaling R-HSA-8939211
Activation of BAD and translocation to mitochondria R-HSA-111447
Mitotic G1 phase and G1/S transition R-HSA-453279
TP53 Regulates Metabolic Genes R-HSA-5628897
Insulin receptor signalling cascade R-HSA-74751
Rab regulation of trafficking R-HSA-9007101
MTOR signalling R-HSA-165159
Regulation of localization of FOXO transcription factors R-HSA-9614399
GPCR downstream signalling R-HSA-388396
Intracellular signaling by second messengers R-HSA-9006925
Cell Cycle R-HSA-1640170
Programmed Cell Death R-HSA-5357801
Transcriptional Regulation by TP53 R-HSA-3700989
Membrane Trafficking R-HSA-199991
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by WNT R-HSA-195721
Regulation of TP53 Expression and Degradation R-HSA-6806003
CD28 co-stimulation R-HSA-389356
G-protein beta:gamma signalling R-HSA-397795
Regulation of PTEN stability and activity R-HSA-8948751
CD28 dependent PI3K/Akt signaling R-HSA-389357
Negative regulation of the PI3K/AKT network R-HSA-199418
Infectious disease R-HSA-5663205
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
SARS-CoV-2-host interactions R-HSA-9705683
Cellular responses to stimuli R-HSA-8953897
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFR2 mediated vascular permeability R-HSA-5218920
Signaling by Insulin receptor R-HSA-74752
RNA Polymerase II Transcription R-HSA-73857
VEGFA-VEGFR2 Pathway R-HSA-4420097
PI3K/AKT Signaling in Cancer R-HSA-2219528
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
IGF1R signaling cascade R-HSA-2428924
CTLA4 inhibitory signaling R-HSA-389513
TCF dependent signaling in response to WNT R-HSA-201681
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cytokine Signaling in Immune system R-HSA-1280215
PKB-mediated events R-HSA-109703
Gene expression (Transcription) R-HSA-74160
PI3K Cascade R-HSA-109704
Extra-nuclear estrogen signaling R-HSA-9009391
Regulation of beta-cell development R-HSA-186712
SARS-CoV-2 Infection R-HSA-9694516
Cellular response to chemical stress R-HSA-9711123
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Activation of BH3-only proteins R-HSA-114452
SARS-CoV Infections R-HSA-9679506
FLT3 Signaling R-HSA-9607240
Intrinsic Pathway for Apoptosis R-HSA-109606
KEAP1-NFE2L2 pathway R-HSA-9755511
Generic Transcription Pathway R-HSA-212436
AKT phosphorylates targets in the nucleus R-HSA-198693
Signaling by ERBB2 R-HSA-1227986
PTEN Regulation R-HSA-6807070
FOXO-mediated transcription R-HSA-9614085
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Regulation of TP53 Activity R-HSA-5633007
Transcriptional regulation by RUNX2 R-HSA-8878166
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
S Phase R-HSA-69242
Costimulation by the CD28 family R-HSA-388841
Cellular responses to stress R-HSA-2262752
Activation of BAD and translocation to mitochondria R-HSA-111447
Developmental Biology R-HSA-1266738
Downregulation of ERBB2 signaling R-HSA-8863795
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
G1/S Transition R-HSA-69206
AKT phosphorylates targets in the cytosol R-HSA-198323
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
Regulation of TP53 Degradation R-HSA-6804757
Cell Cycle, Mitotic R-HSA-69278
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
G beta:gamma signalling through PI3Kgamma R-HSA-392451
PDE3B signalling R-HSA-165160
Cyclin E associated events during G1/S transition R-HSA-69202
Vesicle-mediated transport R-HSA-5653656
Activation of AKT2 R-HSA-165158
AKT-mediated inactivation of FOXO1A R-HSA-211163
Signaling by Nuclear Receptors R-HSA-9006931
IRS-related events triggered by IGF1R R-HSA-2428928
Apoptosis R-HSA-109581
Inhibition of TSC complex formation by PKB R-HSA-165181
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Regulation of gene expression in beta cells R-HSA-210745
PIP3 activates AKT signaling R-HSA-1257604
ESR-mediated signaling R-HSA-8939211
Signaling by GPCR R-HSA-372790
Mitotic G1 phase and G1/S transition R-HSA-453279
IRS-mediated signalling R-HSA-112399
Signaling by VEGF R-HSA-194138
CTLA4 inhibitory signaling R-HSA-389513
IRS-related events triggered by IGF1R R-HSA-2428928
SARS-CoV-2 Infection R-HSA-9694516
CD28 dependent PI3K/Akt signaling R-HSA-389357
Intrinsic Pathway for Apoptosis R-HSA-109606
Apoptosis R-HSA-109581
IRS-mediated signalling R-HSA-112399
KEAP1-NFE2L2 pathway R-HSA-9755511
Mitotic G1 phase and G1/S transition R-HSA-453279
Signal Transduction R-HSA-162582
Downregulation of ERBB2 signaling R-HSA-8863795
S Phase R-HSA-69242
Intracellular signaling by second messengers R-HSA-9006925
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
IGF1R signaling cascade R-HSA-2428924
Insulin receptor signalling cascade R-HSA-74751
Regulation of TP53 Activity R-HSA-5633007
PI3K/AKT Signaling in Cancer R-HSA-2219528
G1/S Transition R-HSA-69206
Rab regulation of trafficking R-HSA-9007101
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cyclin E associated events during G1/S transition R-HSA-69202
Activation of AKT2 R-HSA-165158
Immune System R-HSA-168256
TCF dependent signaling in response to WNT R-HSA-201681
Transcriptional regulation by RUNX2 R-HSA-8878166
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Extra-nuclear estrogen signaling R-HSA-9009391
Transcriptional Regulation by TP53 R-HSA-3700989
Disease R-HSA-1643685
AKT-mediated inactivation of FOXO1A R-HSA-211163
VEGFR2 mediated vascular permeability R-HSA-5218920
G-protein beta:gamma signalling R-HSA-397795
Cellular responses to stimuli R-HSA-8953897
Gene expression (Transcription) R-HSA-74160
PDE3B signalling R-HSA-165160
AKT phosphorylates targets in the cytosol R-HSA-198323
Signaling by Insulin receptor R-HSA-74752
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
FLT3 Signaling R-HSA-9607240
PI3K Cascade R-HSA-109704
Membrane Trafficking R-HSA-199991
ESR-mediated signaling R-HSA-8939211
Programmed Cell Death R-HSA-5357801
CD28 co-stimulation R-HSA-389356
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by VEGF R-HSA-194138
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
Cellular response to chemical stress R-HSA-9711123
PTEN Regulation R-HSA-6807070
Regulation of localization of FOXO transcription factors R-HSA-9614399
Negative regulation of the PI3K/AKT network R-HSA-199418
GPCR downstream signalling R-HSA-388396
SARS-CoV-2-host interactions R-HSA-9705683
PKB-mediated events R-HSA-109703
AKT phosphorylates targets in the nucleus R-HSA-198693
Signaling by GPCR R-HSA-372790
Activation of BAD and translocation to mitochondria R-HSA-111447
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Degradation R-HSA-6804757
Inhibition of TSC complex formation by PKB R-HSA-165181
Developmental Biology R-HSA-1266738
TP53 Regulates Metabolic Genes R-HSA-5628897
Vesicle-mediated transport R-HSA-5653656
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Costimulation by the CD28 family R-HSA-388841
Regulation of gene expression in beta cells R-HSA-210745
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
MTOR signalling R-HSA-165159
Cell Cycle, Mitotic R-HSA-69278
FOXO-mediated transcription R-HSA-9614085
Regulation of beta-cell development R-HSA-186712
SARS-CoV Infections R-HSA-9679506
Signaling by Nuclear Receptors R-HSA-9006931
Generic Transcription Pathway R-HSA-212436
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activation of BH3-only proteins R-HSA-114452
Infectious disease R-HSA-5663205
Adaptive Immune System R-HSA-1280218
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Signaling by ERBB2 R-HSA-1227986
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cellular responses to stress R-HSA-2262752
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
PIP3 activates AKT signaling R-HSA-1257604
Signaling by WNT R-HSA-195721
Regulation of PTEN stability and activity R-HSA-8948751
G1/S Transition R-HSA-69206
Adaptive Immune System R-HSA-1280218
Signaling by Nuclear Receptors R-HSA-9006931
Rab regulation of trafficking R-HSA-9007101
IGF1R signaling cascade R-HSA-2428924
Mitotic G1 phase and G1/S transition R-HSA-453279
PTEN Regulation R-HSA-6807070
Regulation of TP53 Expression and Degradation R-HSA-6806003
Inhibition of TSC complex formation by PKB R-HSA-165181
PKB-mediated events R-HSA-109703
MTOR signalling R-HSA-165159
Downregulation of ERBB2 signaling R-HSA-8863795
Generic Transcription Pathway R-HSA-212436
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Cellular responses to stress R-HSA-2262752
Cyclin E associated events during G1/S transition R-HSA-69202
Transcriptional Regulation by TP53 R-HSA-3700989
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Membrane Trafficking R-HSA-199991
Immune System R-HSA-168256
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
IRS-mediated signalling R-HSA-112399
PI3K Cascade R-HSA-109704
Apoptosis R-HSA-109581
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by WNT R-HSA-195721
PI3K/AKT Signaling in Cancer R-HSA-2219528
Costimulation by the CD28 family R-HSA-388841
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
Regulation of PTEN stability and activity R-HSA-8948751
Intrinsic Pathway for Apoptosis R-HSA-109606
PIP3 activates AKT signaling R-HSA-1257604
GPCR downstream signalling R-HSA-388396
Programmed Cell Death R-HSA-5357801
Intracellular signaling by second messengers R-HSA-9006925
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
SARS-CoV-2 Infection R-HSA-9694516
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
Infectious disease R-HSA-5663205
Activation of AKT2 R-HSA-165158
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Vesicle-mediated transport R-HSA-5653656
Cellular responses to stimuli R-HSA-8953897
G-protein beta:gamma signalling R-HSA-397795
SARS-CoV Infections R-HSA-9679506
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
Signaling by Insulin receptor R-HSA-74752
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by ERBB2 R-HSA-1227986
Cell Cycle R-HSA-1640170
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
VEGFR2 mediated vascular permeability R-HSA-5218920
Regulation of localization of FOXO transcription factors R-HSA-9614399
Activation of BAD and translocation to mitochondria R-HSA-111447
KEAP1-NFE2L2 pathway R-HSA-9755511
CD28 dependent PI3K/Akt signaling R-HSA-389357
SARS-CoV-2-host interactions R-HSA-9705683
IRS-related events triggered by IGF1R R-HSA-2428928
FLT3 Signaling R-HSA-9607240
TP53 Regulates Metabolic Genes R-HSA-5628897
CD28 co-stimulation R-HSA-389356
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by GPCR R-HSA-372790
Transcriptional regulation by RUNX2 R-HSA-8878166
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Cellular response to chemical stress R-HSA-9711123
RNA Polymerase II Transcription R-HSA-73857
Regulation of beta-cell development R-HSA-186712
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Activation of BH3-only proteins R-HSA-114452
TCF dependent signaling in response to WNT R-HSA-201681
Extra-nuclear estrogen signaling R-HSA-9009391
AKT phosphorylates targets in the cytosol R-HSA-198323
FOXO-mediated transcription R-HSA-9614085
Signaling by VEGF R-HSA-194138
CTLA4 inhibitory signaling R-HSA-389513
AKT phosphorylates targets in the nucleus R-HSA-198693
ESR-mediated signaling R-HSA-8939211
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Activity R-HSA-5633007
S Phase R-HSA-69242
Regulation of gene expression in beta cells R-HSA-210745
Regulation of TP53 Degradation R-HSA-6804757
AKT-mediated inactivation of FOXO1A R-HSA-211163
Cell Cycle, Mitotic R-HSA-69278
Insulin receptor signalling cascade R-HSA-74751
PDE3B signalling R-HSA-165160
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
TCF dependent signaling in response to WNT R-HSA-201681
Mitotic G1 phase and G1/S transition R-HSA-453279
GPCR downstream signalling R-HSA-388396
Regulation of TP53 Expression and Degradation R-HSA-6806003
Regulation of gene expression in beta cells R-HSA-210745
Signaling by WNT R-HSA-195721
Activation of AKT2 R-HSA-165158
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Nuclear Receptors R-HSA-9006931
G1/S Transition R-HSA-69206
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
VEGFR2 mediated vascular permeability R-HSA-5218920
Apoptosis R-HSA-109581
Immune System R-HSA-168256
Cell Cycle R-HSA-1640170
Regulation of localization of FOXO transcription factors R-HSA-9614399
IRS-mediated signalling R-HSA-112399
MTOR signalling R-HSA-165159
Signal Transduction R-HSA-162582
Activation of BAD and translocation to mitochondria R-HSA-111447
KEAP1-NFE2L2 pathway R-HSA-9755511
SARS-CoV-2 Infection R-HSA-9694516
VEGFA-VEGFR2 Pathway R-HSA-4420097
AKT-mediated inactivation of FOXO1A R-HSA-211163
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PDE3B signalling R-HSA-165160
Vesicle-mediated transport R-HSA-5653656
Cellular responses to stress R-HSA-2262752
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Degradation R-HSA-6804757
AKT phosphorylates targets in the nucleus R-HSA-198693
Cellular responses to stimuli R-HSA-8953897
Programmed Cell Death R-HSA-5357801
Adaptive Immune System R-HSA-1280218
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
SARS-CoV-2-host interactions R-HSA-9705683
Cellular response to chemical stress R-HSA-9711123
TP53 Regulates Metabolic Genes R-HSA-5628897
Rab regulation of trafficking R-HSA-9007101
PTEN Regulation R-HSA-6807070
PIP3 activates AKT signaling R-HSA-1257604
Signaling by ERBB2 R-HSA-1227986
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Activation of BH3-only proteins R-HSA-114452
Intrinsic Pathway for Apoptosis R-HSA-109606
RUNX2 regulates genes involved in cell migration R-HSA-8941332
G-protein beta:gamma signalling R-HSA-397795
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cytokine Signaling in Immune system R-HSA-1280215
FOXO-mediated transcription R-HSA-9614085
S Phase R-HSA-69242
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Membrane Trafficking R-HSA-199991
Regulation of beta-cell development R-HSA-186712
IGF1R signaling cascade R-HSA-2428924
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
RNA Polymerase II Transcription R-HSA-73857
IRS-related events triggered by IGF1R R-HSA-2428928
Infectious disease R-HSA-5663205
Cyclin E associated events during G1/S transition R-HSA-69202
Transcriptional regulation by RUNX2 R-HSA-8878166
AKT phosphorylates targets in the cytosol R-HSA-198323
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Signaling by VEGF R-HSA-194138
Signaling by Insulin receptor R-HSA-74752
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Cell Cycle, Mitotic R-HSA-69278
Downregulation of ERBB2 signaling R-HSA-8863795
PI3K Cascade R-HSA-109704
Negative regulation of the PI3K/AKT network R-HSA-199418
Generic Transcription Pathway R-HSA-212436
Regulation of PTEN stability and activity R-HSA-8948751
FLT3 Signaling R-HSA-9607240
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Extra-nuclear estrogen signaling R-HSA-9009391
Disease R-HSA-1643685
Regulation of TP53 Activity R-HSA-5633007
PKB-mediated events R-HSA-109703
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
Costimulation by the CD28 family R-HSA-388841
Insulin receptor signalling cascade R-HSA-74751
Developmental Biology R-HSA-1266738
Intracellular signaling by second messengers R-HSA-9006925
CD28 co-stimulation R-HSA-389356
Regulation of TP53 Activity through Acetylation R-HSA-6804758
CTLA4 inhibitory signaling R-HSA-389513
CD28 dependent PI3K/Akt signaling R-HSA-389357
ESR-mediated signaling R-HSA-8939211
Inhibition of TSC complex formation by PKB R-HSA-165181
Gene expression (Transcription) R-HSA-74160
Signaling by GPCR R-HSA-372790
SARS-CoV Infections R-HSA-9679506
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by VEGF R-HSA-194138
SARS-CoV-2 Infection R-HSA-9694516
Cellular responses to stress R-HSA-2262752
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
SARS-CoV-2-host interactions R-HSA-9705683
CTLA4 inhibitory signaling R-HSA-389513
Developmental Biology R-HSA-1266738
GPCR downstream signalling R-HSA-388396
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Gene expression (Transcription) R-HSA-74160
TP53 Regulates Metabolic Genes R-HSA-5628897
Immune System R-HSA-168256
Intracellular signaling by second messengers R-HSA-9006925
Negative regulation of the PI3K/AKT network R-HSA-199418
MTOR signalling R-HSA-165159
Mitotic G1 phase and G1/S transition R-HSA-453279
IRS-related events triggered by IGF1R R-HSA-2428928
ESR-mediated signaling R-HSA-8939211
Regulation of TP53 Activity R-HSA-5633007
KEAP1-NFE2L2 pathway R-HSA-9755511
Signaling by WNT R-HSA-195721
Inhibition of TSC complex formation by PKB R-HSA-165181
Signal Transduction R-HSA-162582
Insulin receptor signalling cascade R-HSA-74751
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulation of localization of FOXO transcription factors R-HSA-9614399
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Membrane Trafficking R-HSA-199991
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
PDE3B signalling R-HSA-165160
Costimulation by the CD28 family R-HSA-388841
Regulation of gene expression in beta cells R-HSA-210745
Adaptive Immune System R-HSA-1280218
PTEN Regulation R-HSA-6807070
VEGFR2 mediated vascular permeability R-HSA-5218920
Signaling by Nuclear Receptors R-HSA-9006931
Apoptosis R-HSA-109581
AKT-mediated inactivation of FOXO1A R-HSA-211163
Programmed Cell Death R-HSA-5357801
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by ERBB2 R-HSA-1227986
Generic Transcription Pathway R-HSA-212436
Signaling by GPCR R-HSA-372790
Cellular response to chemical stress R-HSA-9711123
Regulation of beta-cell development R-HSA-186712
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PKB-mediated events R-HSA-109703
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
CD28 co-stimulation R-HSA-389356
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
TCF dependent signaling in response to WNT R-HSA-201681
Regulation of TP53 Degradation R-HSA-6804757
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
G1/S Transition R-HSA-69206
IRS-mediated signalling R-HSA-112399
Disease R-HSA-1643685
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Acetylation R-HSA-6804758
G-protein beta:gamma signalling R-HSA-397795
Downregulation of ERBB2 signaling R-HSA-8863795
S Phase R-HSA-69242
Extra-nuclear estrogen signaling R-HSA-9009391
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Cell Cycle R-HSA-1640170
IGF1R signaling cascade R-HSA-2428924
Transcriptional regulation by RUNX2 R-HSA-8878166
Regulation of TP53 Expression and Degradation R-HSA-6806003
SARS-CoV Infections R-HSA-9679506
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Activation of BAD and translocation to mitochondria R-HSA-111447
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
CD28 dependent PI3K/Akt signaling R-HSA-389357
Cytokine Signaling in Immune system R-HSA-1280215
Regulation of PTEN stability and activity R-HSA-8948751
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
Rab regulation of trafficking R-HSA-9007101
FLT3 Signaling R-HSA-9607240
PI3K/AKT Signaling in Cancer R-HSA-2219528
FOXO-mediated transcription R-HSA-9614085
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
AKT phosphorylates targets in the nucleus R-HSA-198693
Signaling by Insulin receptor R-HSA-74752
Cyclin E associated events during G1/S transition R-HSA-69202
Infectious disease R-HSA-5663205
Vesicle-mediated transport R-HSA-5653656
PIP3 activates AKT signaling R-HSA-1257604
AKT phosphorylates targets in the cytosol R-HSA-198323
Activation of AKT2 R-HSA-165158
Cell Cycle, Mitotic R-HSA-69278
PI3K Cascade R-HSA-109704
Activation of BH3-only proteins R-HSA-114452
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
Regulation of localization of FOXO transcription factors R-HSA-9614399
TCF dependent signaling in response to WNT R-HSA-201681
AKT phosphorylates targets in the cytosol R-HSA-198323
ESR-mediated signaling R-HSA-8939211
Downregulation of ERBB2 signaling R-HSA-8863795
CD28 co-stimulation R-HSA-389356
MTOR signalling R-HSA-165159
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by ERBB2 R-HSA-1227986
Cytokine Signaling in Immune system R-HSA-1280215
Regulation of beta-cell development R-HSA-186712
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
S Phase R-HSA-69242
Programmed Cell Death R-HSA-5357801
Regulation of TP53 Expression and Degradation R-HSA-6806003
TP53 Regulates Metabolic Genes R-HSA-5628897
Gene expression (Transcription) R-HSA-74160
Cell Cycle R-HSA-1640170
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
Extra-nuclear estrogen signaling R-HSA-9009391
AKT phosphorylates targets in the nucleus R-HSA-198693
IRS-related events triggered by IGF1R R-HSA-2428928
Insulin receptor signalling cascade R-HSA-74751
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Developmental Biology R-HSA-1266738
Signaling by Nuclear Receptors R-HSA-9006931
G beta:gamma signalling through PI3Kgamma R-HSA-392451
SARS-CoV-2 Infection R-HSA-9694516
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
AKT-mediated inactivation of FOXO1A R-HSA-211163
Cyclin E associated events during G1/S transition R-HSA-69202
CD28 dependent PI3K/Akt signaling R-HSA-389357
FOXO-mediated transcription R-HSA-9614085
Generic Transcription Pathway R-HSA-212436
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Insulin receptor R-HSA-74752
Membrane Trafficking R-HSA-199991
Adaptive Immune System R-HSA-1280218
Transcriptional regulation by RUNX2 R-HSA-8878166
RUNX2 regulates genes involved in cell migration R-HSA-8941332
PI3K/AKT Signaling in Cancer R-HSA-2219528
IRS-mediated signalling R-HSA-112399
Costimulation by the CD28 family R-HSA-388841
Rab regulation of trafficking R-HSA-9007101
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
VEGFR2 mediated vascular permeability R-HSA-5218920
CTLA4 inhibitory signaling R-HSA-389513
Regulation of gene expression in beta cells R-HSA-210745
Signaling by VEGF R-HSA-194138
Cellular responses to stimuli R-HSA-8953897
PTEN Regulation R-HSA-6807070
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
IGF1R signaling cascade R-HSA-2428924
Immune System R-HSA-168256
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
Cellular response to chemical stress R-HSA-9711123
Negative regulation of the PI3K/AKT network R-HSA-199418
VEGFA-VEGFR2 Pathway R-HSA-4420097
GPCR downstream signalling R-HSA-388396
FLT3 Signaling R-HSA-9607240
PIP3 activates AKT signaling R-HSA-1257604
Signal Transduction R-HSA-162582
Activation of BAD and translocation to mitochondria R-HSA-111447
Apoptosis R-HSA-109581
Regulation of TP53 Degradation R-HSA-6804757
Signaling by GPCR R-HSA-372790
Regulation of PTEN stability and activity R-HSA-8948751
Cell Cycle, Mitotic R-HSA-69278
SARS-CoV Infections R-HSA-9679506
Activation of AKT2 R-HSA-165158
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
G1/S Transition R-HSA-69206
Intrinsic Pathway for Apoptosis R-HSA-109606
PI3K Cascade R-HSA-109704
Activation of BH3-only proteins R-HSA-114452
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
Cellular responses to stress R-HSA-2262752
PDE3B signalling R-HSA-165160
PKB-mediated events R-HSA-109703
Mitotic G1 phase and G1/S transition R-HSA-453279
Inhibition of TSC complex formation by PKB R-HSA-165181
Vesicle-mediated transport R-HSA-5653656
Regulation of TP53 Activity R-HSA-5633007
Signaling by WNT R-HSA-195721
G-protein beta:gamma signalling R-HSA-397795
KEAP1-NFE2L2 pathway R-HSA-9755511
SARS-CoV-2-host interactions R-HSA-9705683
Immune System R-HSA-168256
Activation of BH3-only proteins R-HSA-114452
VEGFR2 mediated vascular permeability R-HSA-5218920
Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1445148
IRS-mediated signalling R-HSA-112399
Cell Cycle, Mitotic R-HSA-69278
SARS-CoV Infections R-HSA-9679506
Apoptosis R-HSA-109581
Mitotic G1 phase and G1/S transition R-HSA-453279
Activation of BAD and translocation to mitochondria R-HSA-111447
Costimulation by the CD28 family R-HSA-388841
Vesicle-mediated transport R-HSA-5653656
Regulation of TP53 Expression and Degradation R-HSA-6806003
G beta:gamma signalling through PI3Kgamma R-HSA-392451
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Activation of AKT2 R-HSA-165158
G-protein beta:gamma signalling R-HSA-397795
Membrane Trafficking R-HSA-199991
Cyclin E associated events during G1/S transition R-HSA-69202
Signaling by Insulin receptor R-HSA-74752
Regulation of TP53 Activity through Acetylation R-HSA-6804758
Signaling by Nuclear Receptors R-HSA-9006931
VEGFA-VEGFR2 Pathway R-HSA-4420097
Developmental Biology R-HSA-1266738
TCF dependent signaling in response to WNT R-HSA-201681
TP53 Regulates Metabolic Genes R-HSA-5628897
IRS-related events triggered by IGF1R R-HSA-2428928
AKT phosphorylates targets in the cytosol R-HSA-198323
Regulation of TP53 Activity through Association with Co-factors R-HSA-6804759
PI3K Cascade R-HSA-109704
Signaling by WNT R-HSA-195721
Regulation of PTEN stability and activity R-HSA-8948751
Programmed Cell Death R-HSA-5357801
SARS-CoV-2 targets host intracellular signalling and regulatory pathways R-HSA-9755779
CD28 co-stimulation R-HSA-389356
IGF1R signaling cascade R-HSA-2428924
S Phase R-HSA-69242
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Infectious disease R-HSA-5663205
MTOR signalling R-HSA-165159
CD28 dependent PI3K/Akt signaling R-HSA-389357
FLT3 Signaling R-HSA-9607240
AKT-mediated inactivation of FOXO1A R-HSA-211163
Gene expression (Transcription) R-HSA-74160
Cellular responses to stress R-HSA-2262752
Disease R-HSA-1643685
PI3K/AKT Signaling in Cancer R-HSA-2219528
Inhibition of TSC complex formation by PKB R-HSA-165181
ESR-mediated signaling R-HSA-8939211
GPCR downstream signalling R-HSA-388396
Transcriptional regulation by RUNX2 R-HSA-8878166
SARS-CoV-2-host interactions R-HSA-9705683
Generic Transcription Pathway R-HSA-212436
PTEN Regulation R-HSA-6807070
Rab regulation of trafficking R-HSA-9007101
Signaling by ERBB2 R-HSA-1227986
Intrinsic Pathway for Apoptosis R-HSA-109606
RNA Polymerase II Transcription R-HSA-73857
Cellular response to chemical stress R-HSA-9711123
Regulation of beta-cell development R-HSA-186712
Deactivation of the beta-catenin transactivating complex R-HSA-3769402
Signaling by GPCR R-HSA-372790
Intracellular signaling by second messengers R-HSA-9006925
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
RUNX2 regulates genes involved in cell migration R-HSA-8941332
Regulation of gene expression in beta cells R-HSA-210745
Regulation of localization of FOXO transcription factors R-HSA-9614399
Regulation of TP53 Degradation R-HSA-6804757
PIP3 activates AKT signaling R-HSA-1257604
AKT phosphorylates targets in the nucleus R-HSA-198693
Signal Transduction R-HSA-162582
KEAP1-NFE2L2 pathway R-HSA-9755511
CTLA4 inhibitory signaling R-HSA-389513
Negative regulation of the PI3K/AKT network R-HSA-199418
Adaptive Immune System R-HSA-1280218
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
RAB GEFs exchange GTP for GDP on RABs R-HSA-8876198
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cell Cycle R-HSA-1640170
Cellular responses to stimuli R-HSA-8953897
FOXO-mediated transcription R-HSA-9614085
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Extra-nuclear estrogen signaling R-HSA-9009391
G1/S Transition R-HSA-69206
Regulation of TP53 Activity R-HSA-5633007
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV-2 Infection R-HSA-9694516
Insulin receptor signalling cascade R-HSA-74751
Signaling by VEGF R-HSA-194138
Downregulation of ERBB2 signaling R-HSA-8863795
PDE3B signalling R-HSA-165160
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PKB-mediated events R-HSA-109703

Expression Atlas ENSG00000105221
LRG display in Ensembl gene LRG_1391
NCBI gene (formerly Entrezgene) 208
GeneCards 392
HGNC Symbol HGNC:392
MIM gene 164731
MIM morbid 240900
UniProtKB Gene Name P31751
WikiGene 208
Gene: CYP3A5
Ensembl ID : ENSG00000106258
Description: cytochrome P450 family 3 subfamily A member 5
Gene Synonyms: CP35,P450PCN3,PCN3
2 APIs:
643 Possible Orthologues:

Biological oxidations R-HSA-211859
Xenobiotics R-HSA-211981
Cytochrome P450 - arranged by substrate type R-HSA-211897
Metabolism R-HSA-1430728
Aflatoxin activation and detoxification R-HSA-5423646
Phase I - Functionalization of compounds R-HSA-211945
Metabolism R-HSA-1430728
Phase I - Functionalization of compounds R-HSA-211945
Cytochrome P450 - arranged by substrate type R-HSA-211897
Xenobiotics R-HSA-211981
Aflatoxin activation and detoxification R-HSA-5423646
Biological oxidations R-HSA-211859
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Aflatoxin activation and detoxification R-HSA-5423646
Metabolism R-HSA-1430728
Phase I - Functionalization of compounds R-HSA-211945
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Xenobiotics R-HSA-211981
Aflatoxin activation and detoxification R-HSA-5423646
Aflatoxin activation and detoxification R-HSA-5423646
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Metabolism R-HSA-1430728
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
Xenobiotics R-HSA-211981
Phase I - Functionalization of compounds R-HSA-211945
Aflatoxin activation and detoxification R-HSA-5423646
Metabolism R-HSA-1430728
Cytochrome P450 - arranged by substrate type R-HSA-211897
Biological oxidations R-HSA-211859
Phase I - Functionalization of compounds R-HSA-211945
Biological oxidations R-HSA-211859
Xenobiotics R-HSA-211981
Aflatoxin activation and detoxification R-HSA-5423646
Cytochrome P450 - arranged by substrate type R-HSA-211897
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Xenobiotics R-HSA-211981
Aflatoxin activation and detoxification R-HSA-5423646
Metabolism R-HSA-1430728
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
Phase I - Functionalization of compounds R-HSA-211945
Biological oxidations R-HSA-211859
Aflatoxin activation and detoxification R-HSA-5423646
Metabolism R-HSA-1430728
Cytochrome P450 - arranged by substrate type R-HSA-211897

Expression Atlas ENSG00000106258
LRG display in Ensembl gene LRG_1431
NCBI gene (formerly Entrezgene) 1577
GeneCards 2638
HGNC Symbol HGNC:2638
MIM gene 605325
MIM morbid 145500
UniProtKB Gene Name Q7Z3N0
WikiGene 1577