BUPROFEZIN

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UNII 3B8KGI239I
Source Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Sci Data. 2015 Jul 7;2:150032. Read more ...

Structure

InChI Key PRLVTUNWOQKEAI-VKAVYKQESA-N
Smiles CC(C)N1\C(=N\C(C)(C)C)\SCN(C1=O)c2ccccc2
InChI
InChI=1S/C16H23N3OS/c1-12(2)19-14(17-16(3,4)5)21-11-18(15(19)20)13-9-7-6-8-10-13/h6-10,12H,11H2,1-5H3/b17-14-

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H23N3OS
Molecular Weight 305.44
AlogP 4.06
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 3.0
Polar Surface Area 61.21
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 21.0
Assay Description Organism Bioactivity Reference
Residual toxicity against compound treated rice leaves-fed adult Anagrus nilaparvatae assessed as mortality measured on day 0 post insecticide treatment to plant Anagrus 1.1 %
Acute contact toxicity against adult Anagrus nilaparvatae assessed as dead parasitoid wasps compound treated for 1 hr measured after 8 hr wash-out period Anagrus 1000.0 mgAi/L
Acute oral toxicity against female adult Anagrus nilaparvatae in petridish under laboratory conditions assessed as mortality compound treated as emulsible concentrate with acetone and Triton X-100 measured after 1 to 8 hr Anagrus 29.4 %
Insecticidal activity against Bemisia tabaci F1 (sweet potato whitefly) pooled/Bupro-SEL hybrid assessed as mortality measured after 18 to 20 days Bemisia tabaci 62.6 ugAi/ml
Insecticidal activity against Bemisia tabaci F1 (sweet potato whitefly) pooled assessed as mortality measured after 18 to 20 days Bemisia tabaci 4.86 ugAi/ml
Insecticidal activity against Bemisia tabaci Bupro-SEL (sweet potato whitefly) male/Lab-PK female hybrid assessed as mortality measured after 18 to 20 days Bemisia tabaci 4.41 ugAi/ml
Insecticidal activity against Bemisia tabaci Bupro-SEL (sweet potato whitefly) female/Lab-PK male hybrid assessed as mortality measured after 18 to 20 days Bemisia tabaci 5.11 ugAi/ml
Insecticidal activity against Bemisia tabaci Bupro-SEL (sweet potato whitefly) from 20 generation buprofezin resistance assessed as mortality measured after 18 to 20 days Bemisia tabaci 115.2 ugAi/ml
Insecticidal activity against Bemisia tabaci Bupro-SEL (sweet potato whitefly) from 10 generation buprofezin resistance assessed as mortality measured after 18 to 20 days Bemisia tabaci 1400.0 ugAi/ml
Insecticidal activity against Bemisia tabaci UNSEL G11 (sweet potato whitefly) from 11 generation buprofezin resistance assessed as mortality measured after 18 to 20 days Bemisia tabaci 0.25 ugAi/ml
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) from one generation buprofezin resistance G1 assessed as mortality measured after 18 to 20 days Bemisia tabaci 1.41 ugAi/ml
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) susceptible Lab-PK assessed as mortality measured after 18 to 20 days Bemisia tabaci 0.2 ugAi/ml
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as offspring sex ratio at LC25 concentration at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb Female/Female + male)= 0.60 no unit) Bemisia tabaci 0.5
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as longevity at LC25 concentration at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 8.31 days) Bemisia tabaci 4.85 day
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as egg hatch at LC25 concentration at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 87.73 days) Bemisia tabaci 66.0 %
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as laid eggs at LC25 concentration at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr Bemisia tabaci None
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at egg stage in compound treated cucumber leaves assessed as egg hatch at 10000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 10 days (Rvb = 91%) Bemisia tabaci 72.0 %
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at egg stage in compound treated cucumber leaves assessed as egg hatch at 8000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 10 days (Rvb = 91%) Bemisia tabaci 68.0 %
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at egg stage in compound treated cucumber leaves assessed as egg hatch at 2000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 10 days (Rvb = 91%) Bemisia tabaci 88.0 %
Insecticidal activity against male Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality at 8000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 6.3%) Bemisia tabaci 10.0 %
Insecticidal activity against male Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality at 2000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 6.3%) Bemisia tabaci 11.3 %
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality at 10000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 9.3%) Bemisia tabaci 9.3 %
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality at 8000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 9.3%) Bemisia tabaci 8.0 %
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality at 2000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 9.3%) Bemisia tabaci 8.0 %
Insecticidal activity against male Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality after 48 hr Bemisia tabaci None
Insecticidal activity against adult female Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality after 48 hr Bemisia tabaci None
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at pupae stage in compound treated cucumber leaves assessed as mortality measured as dry larvae and detached from leaf at 25 +/- 1 degC, 70 +/- 5% RH after 7 days Bemisia tabaci 979.05 ppm
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at third instar larvae stage in compound treated cucumber leaves assessed as mortality measured as dry larvae and detached from leaf at 25 +/- 1 degC, 70 +/- 5% RH after 7 days Bemisia tabaci 44.7 ppm
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at second instar larvae stage in compound treated cucumber leaves assessed as mortality measured as dry larvae and detached from leaf at 25 +/- 1 degC, 70 +/- 5% RH after 7 days Bemisia tabaci 10.93 ppm
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at first instar larvae stage in compound treated cucumber leaves assessed as mortality measured as dry larvae and detached from leaf at 25 +/- 1 degC, 70 +/- 5% RH after 7 days Bemisia tabaci 0.99 ppm
Insecticidal activity against Bemisia tabaci (sweet potato whitefly) at egg stage in compound treated cucumber leaves assessed as mortality measured as failure to hatch at 25 +/- 1 degC, 70 +/- 5% RH after 10 days Bemisia tabaci None
Insecticidal activity against male Bemisia tabaci (sweet potato whitefly) in compound treated cucumber leaves assessed as mortality at 10000 ppm at 25 +/- 1 degC, 70 +/- 5% RH after 48 hr (Rvb = 6.3%) Bemisia tabaci 19.0 %
Insecticidal activity against Encarsia inaron treated at adult stages assessed as doubling time at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at adult stages assessed as mean generation time at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at adult stages assessed as finite rate of increase at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at adult stages assessed as intrinsic rate of increase at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at adult stages assessed as increase in net reproductive rate at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at pupal stages assessed as mean generation time at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at pupal stages assessed as net reproductive rate at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at pupal stages assessed as finite rate increase at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at pupal stages assessed as intrinsic rate of increase at 2000 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at larval stages assessed as mean generation time at 31.25 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at larval stages assessed as finite rate of increase at 31.25 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at larval stages assessed as intrinsic rate of increase at 31.25 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at larval stages assessed as increase in net reproductive rate at 31.25 ppm Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at adult stages at 2000 ppm assessed as sex ratio (Rvb = 0.72 no unit) Encarsia inaron 0.44
Insecticidal activity against Encarsia inaron treated at pupal stages at 2000 ppm assessed as sex ratio (Rvb = 0.68 no unit) Encarsia inaron 0.44
Insecticidal activity against Encarsia inaron treated at larval stages at 31.25 ppm assessed as sex ratio (Rvb = 0.72 no unit) Encarsia inaron 0.49
Insecticidal activity against Encarsia inaron treated at adult stages at 2000 ppm assessed as insects eggs level per day (Rvb = 2.33 egg/day) Encarsia inaron 4.58 /day
Insecticidal activity against Encarsia inaron treated at pupal stages at 2000 ppm assessed as insects eggs level per day (Rvb = 2.37 egg/day) Encarsia inaron 1.24 /day
Insecticidal activity against Encarsia inaron treated at larval stages at 31.25 ppm assessed as insects eggs level per day (Rvb = 2.98 egg/day) Encarsia inaron 3.55 /day
Insecticidal activity against Encarsia inaron treated at adult stages at 2000 ppm assessed as insect total fecundity Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at pupal stages at 2000 ppm assessed as insect total fecundity Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at larval stages at 31.25 ppm assessed as insect total fecundity Encarsia inaron None
Insecticidal activity against Encarsia inaron treated at adult stages at 2000 ppm assessed as insect longevity (Rvb = 8.95 days) Encarsia inaron 8.9 day
Insecticidal activity against Encarsia inaron treated at pupal stages at 2000 ppm assessed as insect longevity (Rvb = 8.7 days) Encarsia inaron 8.5 day
Insecticidal activity against Encarsia inaron treated at larval stages at 31.25 ppm assessed as insect longevity (Rvb = 5.60 days) Encarsia inaron 7.05 day
Insecticidal activity against Encarsia inaron adults reared on compound treated freshly cut cucumber leaves assessed as induction if insect mortality measured 48 hr post compound treatment Encarsia inaron None
Insecticidal activity against Encarsia inaron infested cucumber plants assessed as adult parasitoid emergence from parasitised host nymphs treated at pupae stages at 400 g ai/L SC measured 10 days post compound treatment (Rvb = 79.60 %) Encarsia inaron 63.4 %
Insecticidal activity against Encarsia inaron infested cucumber plants assessed as adult parasitoid emergence from parasitised host nymphs treated at larval stages at 400 g ai/L SC measured 10 days post compound treatment (Rvb = 79.60 %) Encarsia inaron 2.6 %
Ratio of EC50 for Daphnia magna to EC50 for first instar larvae of Cheumatopsyche brevilineata None 0.37
Insecticidal activity against first-instar larvae of Cheumatopsyche brevilineata after 48 hr Cheumatopsyche 0.181 ug.mL-1
Octanol-water partition coefficient, log KOW of the compound None 4.3
Insecticidal activity against Daphnia magna after 48 hr Daphnia magna 0.42 ug.mL-1
Effect on life span in Nilaparvata lugens (brown planthopper) adult at 0.00064 ppm measured after 7 days relative to control Nilaparvata lugens 106.0 %
Effect on life span in Nilaparvata lugens (brown planthopper) adult at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 101.0 %
Effect on life span in Nilaparvata lugens (brown planthopper) adult at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 78.0 %
Effect on life span in Nilaparvata lugens (brown planthopper) adult at 10 ppm measured after 7 days relative to control Nilaparvata lugens 28.0 %
Effect on development of ovarioles in Nilaparvata lugens (brown planthopper) assessed as number of ovarioles at 0.00064 ppm measured after 7 days relative to control Nilaparvata lugens 103.0 %
Effect on development of ovarioles in Nilaparvata lugens (brown planthopper) assessed as number of ovarioles at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 106.0 %
Effect on development of ovarioles in Nilaparvata lugens (brown planthopper) assessed as number of ovarioles at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 107.0 %
Effect on egg maturity in Nilaparvata lugens (brown planthopper) at 0.00064 ppm measured after 7 days relative to control Nilaparvata lugens 98.0 %
Effect on egg maturity in Nilaparvata lugens (brown planthopper) at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 106.0 %
Effect on egg maturity in Nilaparvata lugens (brown planthopper) at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 100.0 %
Effect on hatchability in Nilaparvata lugens (brown planthopper) at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 96.0 %
Effect on hatchability in Nilaparvata lugens (brown planthopper) at 0.08 ppm measured after 7 days relative to control Nilaparvata lugens 98.0 %
Effect on hatchability in Nilaparvata lugens (brown planthopper) at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 97.0 %
Effect on hatchability in Nilaparvata lugens (brown planthopper) at 2 ppm measured after 7 days relative to control Nilaparvata lugens 74.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.0000256 ppm measured after 7 days relative to control Nilaparvata lugens 97.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.000128 ppm measured after 7 days relative to control Nilaparvata lugens 117.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.0032 ppm measured after 7 days relative to control Nilaparvata lugens 115.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.00064 ppm measured after 7 days relative to control Nilaparvata lugens 88.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.08 ppm measured after 7 days relative to control Nilaparvata lugens 111.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 92.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 79.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 2 ppm measured after 7 days relative to control Nilaparvata lugens 36.0 %
Effect on oviposition in Nilaparvata lugens (brown planthopper) assessed as eggs laid at 10 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.0000256 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.000128 ppm measured after 7 days relative to control Nilaparvata lugens 11.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.00064 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.0032 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 3.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.08 ppm measured after 7 days relative to control Nilaparvata lugens 9.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 19.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 2 ppm measured after 7 days relative to control Nilaparvata lugens 69.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 10 ppm measured after 7 days relative to control Nilaparvata lugens 95.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) assessed as mortality at 50 ppm measured after 7 days relative to control Nilaparvata lugens 100.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.0000256 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.000128 ppm measured after 7 days relative to control Nilaparvata lugens 11.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.0032 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.00064 ppm measured after 7 days relative to control Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.016 ppm measured after 7 days relative to control Nilaparvata lugens 3.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.08 ppm measured after 7 days relative to control Nilaparvata lugens 9.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 0.4 ppm measured after 7 days relative to control Nilaparvata lugens 13.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 2 ppm measured after 7 days relative to control Nilaparvata lugens 69.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) emerged female adult assessed as mortality at 10 ppm measured after 7 days relative to control Nilaparvata lugens 57.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.0000256 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.000128 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.00064 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.0032 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.08 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.016 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 0.4 ppm measured after 7 days Nilaparvata lugens 7.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 2 ppm measured after 7 days Nilaparvata lugens 0.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 10 ppm measured after 7 days Nilaparvata lugens 89.0 %
Insecticidal activity against Nilaparvata lugens (brown planthopper) fifth-instar nymphs assessed as mortality at 50 ppm measured after 7 days Nilaparvata lugens 100.0 %

Cross References

Resources Reference
ChEMBL CHEMBL1891512
FDA SRS 3B8KGI239I
SureChEMBL SCHEMBL26901
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