FLUCYCLOXURON

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Synonyms
UNII V8H544MV3H
Source Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Sci Data. 2015 Jul 7;2:150032. Read more ...

Structure

InChI Key PCKNFPQPGUWFHO-UQRQXUALSA-N
Smiles Fc1cccc(F)c1C(=O)NC(=O)Nc2ccc(CO\N=C(/C3CC3)\c4ccc(Cl)cc4)cc2
InChI
InChI=1S/C25H20ClF2N3O3/c26-18-10-8-17(9-11-18)23(16-6-7-16)31-34-14-15-4-12-19(13-5-15)29-25(33)30-24(32)22-20(27)2-1-3-21(22)28/h1-5,8-13,16H,6-7,14H2,(H2,29,30,32,33)/b31-23+

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H20ClF2N3O3
Molecular Weight 483.89
AlogP 5.66
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 79.79
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 34.0
Assay Description Organism Bioactivity Reference
Insecticidal activity against Plutella xylostella (diamondback moth) s-instar larvae infested on compound pre-treated fresh cabbage leaves assessed as larvicidal activity measured 3 days post treatment Plutella xylostella 72.92 ug.mL-1
Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as larvicidal activity at 0.025 mg/L measured 8 days post treatment Culex pipiens pallens 15.0 %
Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as larvicidal activity at 0.05 mg/L measured 8 days post treatment Culex pipiens pallens 100.0 %
Insecticidal activity against Culex pipiens pallens (mosquito) fourth-instar larvae assessed as larvicidal activity at 0.1 mg/L measured 8 days post treatment Culex pipiens pallens 100.0 %
Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infested compound pre-treated corn leaves assessed as larvicidal activity at 2.5 mg/L measured 4 days post treatment Mythimna separata 50.0 %
Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infested compound pre-treated corn leaves assessed as larvicidal activity at 1 mg/L measured 4 days post treatment Mythimna separata 10.0 %
Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infested compound pre-treated corn leaves assessed as larvicidal activity at 5 mg/L measured 4 days post treatment Mythimna separata 90.0 %
Insecticidal activity against Mythimna separata (Oriental armyworm) fourth-instar larvae infested compound pre-treated corn leaves assessed as larvicidal activity at 10 mg/L measured 4 days post treatment Mythimna separata 95.0 %
Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 25 +/-1 degC after 4 days Mythimna separata 2.44 ug.mL-1
Larvicidal activity against fourth-instar larval stage of Culex pipiens pallens (mosquito) assessed as mortality at 0.01 mg/l at 25 +/-1 degC after 8 days Culex pipiens pallens 0.0 %
Larvicidal activity against fourth-instar larval stage of Culex pipiens pallens (mosquito) assessed as mortality at 0.05 mg/l at 25 +/-1 degC after 8 days Culex pipiens pallens 100.0 %
Larvicidal activity against fourth-instar larval stage of Culex pipiens pallens (mosquito) assessed as mortality at 0.025 mg/l at 25 +/-1 degC after 8 days Culex pipiens pallens 15.0 %
Larvicidal activity against fourth-instar larval stage of Culex pipiens pallens (mosquito) assessed as mortality at 0.1 mg/l at 25 +/-1 degC after 8 days Culex pipiens pallens 100.0 %
Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 5 mg/l at 25 +/-1 degC after 4 days Mythimna separata 90.0 %
Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 10 mg/l at 25 +/-1 degC after 4 days Mythimna separata 95.0 %
Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 0.5 mg/l at 25 +/-1 degC after 4 days Mythimna separata 0.0 %
Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 2.5 mg/l at 25 +/-1 degC after 4 days Mythimna separata 50.0 %
Larvicidal activity against fourth-instar larval stage of Mythimna separata (Oriental armyworm) in compound-pretreated corn leaves assessed as mortality at 1 mg/l at 25 +/-1 degC after 4 days Mythimna separata 10.0 %
Toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 125 mg a.i./l, po administered through sugar water for 11 weeks measured once a week for 11 weeks relative to control Bombus terrestris None
Toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 125 mg a.i./l, po administered through pollen for 11 weeks measured once a week for 11 weeks Bombus terrestris None
Contact toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 125 mg a.i./l applied on the dorsal thorax for 11 weeks measured once a week for 11 weeks relative to control Bombus terrestris None
Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 125 mg a.i./l, po administered through pollen for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks Bombus terrestris None
Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 125 mg a.i./l, po administered through sugar water for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks Bombus terrestris 25.0 %
Contact toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 125 mg a.i./l applied on the dorsal thorax for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks Bombus terrestris 25.0 %
Larvicidal activity against second-instar larvae of Plutella xylostella (diamondback moth) infected in compound-treated cabbage leaves measured after 4 days Plutella xylostella 72.92 ug.mL-1
Larvicidal activity against fourth instar larvae of Mythimna separata (Oriental armyworm) infected compound-treated corn leaves assessed as mortality at 1 mg/l measured after 4 days Mythimna separata 10.0 %
Larvicidal activity against fourth instar larvae of Mythimna separata (Oriental armyworm) infected compound-treated corn leaves assessed as mortality at 2.5 mg/l measured after 4 days Mythimna separata 50.0 %
Larvicidal activity against fourth instar larvae of Mythimna separata (Oriental armyworm) infected compound-treated corn leaves assessed as mortality at 5 mg/l measured after 4 days Mythimna separata 90.0 %

Cross References

Resources Reference
ChEMBL CHEMBL226430
FDA SRS V8H544MV3H
PubChem 6537963
SureChEMBL SCHEMBL27068
CONTENTS