INFIGRATINIB PHOSPHATE


Synonyms	BGJ-398 phosphate Infigratinib monophosphate Infigratinib phosphate Truseltiq
Status
Molecule Category	Salt-form
UNII	58BH47BV6S


InChI Key	GUQNHCGYHLSITB-UHFFFAOYSA-N
Smiles	CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1.O=P(O)(O)O
InChI	InChI=1S/C26H31Cl2N7O3.H3O4P/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28;1-5(2,3)4/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31);(H3,1,2,3,4)

Mechanism of Action	Action	Reference
Fibroblast growth factor receptor inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	0.7-168	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	750	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	300	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	180-938	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	4.9-52.2	-	-	-
Mus musculus	-	2	-	-	-


Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 1 Organism : Homo sapiens P11362 ENSG00000077782












Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 2 Organism : Homo sapiens P21802 ENSG00000066468












Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 4 Organism : Homo sapiens P22455 ENSG00000160867










Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 3 Organism : Homo sapiens P22607 ENSG00000068078

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