AZD-6703

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
UNII 8QS8G2Y8E0

Structure

InChI Key ZMAZXHICVRYLQN-UHFFFAOYSA-N
Smiles Cc1ccc(C(=O)NC2CC2)cc1-n1cnc2ccc(N3CCN(C)CC3)cc2c1=O
InChI
InChI=1S/C24H27N5O2/c1-16-3-4-17(23(30)26-18-5-6-18)13-22(16)29-15-25-21-8-7-19(14-20(21)24(29)31)28-11-9-27(2)10-12-28/h3-4,7-8,13-15,18H,5-6,9-12H2,1-2H3,(H,26,30)

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H27N5O2
Molecular Weight 417.51
AlogP 2.34
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 70.47
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 31.0

Pharmacology

Mechanism of Action Action Reference
MAP kinase p38 alpha inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase MAPK family CMGC protein kinase p38 subfamily
- 15.85-50.12 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 17.38-50.12 - - -

Target Conservation

Protein: MAP kinase p38 alpha
Description: Mitogen-activated protein kinase 14
Organism : Homo sapiens
Q16539 ENSG00000112062

Cross References

Resources Reference
ChEMBL CHEMBL2031465
FDA SRS 8QS8G2Y8E0
Guide to Pharmacology 7687
PDB NQB
SureChEMBL SCHEMBL1140074
ZINC ZINC000084651956
CONTENTS