FULACIMSTAT

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Search structure


Synonyms	BAY-1142524 BAY1142524 Bay1142524 Fulacimstat
Status
Molecule Category	Free-form
UNII	VIR72PP4ZU

Structure


InChI Key	JDARDSVOVYVQST-MRXNPFEDSA-N
Smiles	Cn1c(=O)oc2cc(-n3cc(C(=O)O)c(=O)n([C@@H]4CCc5c4cccc5C(F)(F)F)c3=O)ccc21
InChI	InChI=1S/C23H16F3N3O6/c1-27-17-7-5-11(9-18(17)35-22(27)34)28-10-14(20(31)32)19(30)29(21(28)33)16-8-6-12-13(16)3-2-4-15(12)23(24,25)26/h2-5,7,9-10,16H,6,8H2,1H3,(H,31,32)/t16-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H16F3N3O6
Molecular Weight	487.39
AlogP	2.7
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	116.44
Molecular species	ACID
Aromatic Rings	4.0
Heavy Atoms	35.0

Pharmacology

Mechanism of Action	Action	Reference
Chymase inhibitor	INHIBITOR	PubMed PubMed

Target Conservation


Protein: Chymase Description: Chymase Organism : Homo sapiens P23946 ENSG00000092009

Cross References

Resources	Reference
ChEMBL	CHEMBL4297596
DrugBank	DB15085
FDA SRS	VIR72PP4ZU
PubChem	91758792
SureChEMBL	SCHEMBL16701233

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025