EcoDrugPlus


Synonyms	ACR-325 ACR325 Acr325 Ordopidine
Status
Molecule Category	Free-form
UNII	0P43SIA7J6
EPA CompTox	DTXSID60236146

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	UKUPJASJNQDHPH-UHFFFAOYSA-N
Smiles	CCN1CCC(c2cccc(S(C)(=O)=O)c2F)CC1
InChI	InChI=1S/C14H20FNO2S/c1-3-16-9-7-11(8-10-16)12-5-4-6-13(14(12)15)19(2,17)18/h4-6,11H,3,7-10H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H20FNO2S
Molecular Weight	285.38
AlogP	2.43
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	3.0
Polar Surface Area	37.38
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	19.0

Mechanism of Action	Action	Reference
Dopamine D2 receptor modulator	MODULATOR	PubMed Other

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295

Cross References

Resources	Reference
ChEMBL	CHEMBL3545010
FDA SRS	0P43SIA7J6
PubChem	11701939
SureChEMBL	SCHEMBL2370600

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ORDOPIDINE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References