AMELUBANT

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Search structure


Synonyms	Amelubant BIIL 284 BIIL 284 BS BIIL-284 BIIL-284BS Biil 284 bs LS-49968
Status
Molecule Category	Free-form
UNII	E0018IF0K4

Structure


InChI Key	SBVYURPQULDJTI-UHFFFAOYSA-N
Smiles	CCOC(=O)NC(=N)c1ccc(OCc2cccc(COc3ccc(C(C)(C)c4ccc(O)cc4)cc3)c2)cc1
InChI	InChI=1S/C33H34N2O5/c1-4-38-32(37)35-31(34)25-8-16-29(17-9-25)39-21-23-6-5-7-24(20-23)22-40-30-18-12-27(13-19-30)33(2,3)26-10-14-28(36)15-11-26/h5-20,36H,4,21-22H2,1-3H3,(H2,34,35,37)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C33H34N2O5
Molecular Weight	538.64
AlogP	6.95
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	10.0
Polar Surface Area	100.87
Molecular species	NEUTRAL
Aromatic Rings	4.0
Heavy Atoms	40.0

Pharmacology

Mechanism of Action	Action	Reference
Leukotriene B4 receptor 1 antagonist	ANTAGONIST	PubMed

Target Conservation


Protein: Leukotriene B4 receptor 1 Description: Leukotriene B4 receptor 1 Organism : Homo sapiens Q15722 ENSG00000213903

Cross References

Resources	Reference
ChEMBL	CHEMBL1742420
DrugBank	DB06248
FDA SRS	E0018IF0K4
Guide to Pharmacology	8463
PubChem	9915203
SureChEMBL	SCHEMBL1891670
ZINC	ZINC000004392964

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025