NETOGLITAZONE

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Search structure


Synonyms	MCC 555 Mcc-555 Netoglitazone PGX-510 RWJ-241947
Status
Molecule Category	Free-form
UNII	QOV2JZ647A
EPA CompTox	DTXSID5043712

Structure


InChI Key	PKWDZWYVIHVNKS-UHFFFAOYSA-N
Smiles	O=C1NC(=O)C(Cc2ccc3cc(OCc4ccccc4F)ccc3c2)S1
InChI	InChI=1S/C21H16FNO3S/c22-18-4-2-1-3-16(18)12-26-17-8-7-14-9-13(5-6-15(14)11-17)10-19-20(24)23-21(25)27-19/h1-9,11,19H,10,12H2,(H,23,24,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H16FNO3S
Molecular Weight	381.43
AlogP	4.45
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	55.4
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	27.0

Pharmacology

Mechanism of Action	Action	Reference
Peroxisome proliferator-activated receptor gamma modulator	MODULATOR	PubMed

Target Conservation


Protein: Peroxisome proliferator-activated receptor gamma Description: Peroxisome proliferator-activated receptor gamma Organism : Homo sapiens P37231 ENSG00000132170

Cross References

Resources	Reference
ChEMBL	CHEMBL93747
DrugBank	DB09199
FDA SRS	QOV2JZ647A
Guide to Pharmacology	2707
PubChem	204109
SureChEMBL	SCHEMBL142658

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025