EcoDrugPlus


Synonyms	AZD1390 Azd-1390 Azd1390
Status
Molecule Category	Free-form
UNII	CI43QFE22O

Synonyms

AZD1390

Azd-1390

Azd1390

Status

Molecule Category

Free-form

UNII

CI43QFE22O


InChI Key	VQSZIPCGAGVRRP-UHFFFAOYSA-N
Smiles	CC(C)n1c(=O)n(C)c2cnc3cc(F)c(-c4ccc(OCCCN5CCCCC5)nc4)cc3c21
InChI	InChI=1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3

InChI Key

VQSZIPCGAGVRRP-UHFFFAOYSA-N

Smiles

CC(C)n1c(=O)n(C)c2cnc3cc(F)c(-c4ccc(OCCCN5CCCCC5)nc4)cc3c21

InChI

InChI=1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3

Property Name	Value
Molecular Formula	C27H32FN5O2
Molecular Weight	477.58
AlogP	4.93
Hydrogen Bond Acceptor	7.0
Number of Rotational Bond	7.0
Polar Surface Area	65.18
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	35.0

Property Name

Value

Molecular Formula

C27H32FN5O2

Molecular Weight

477.58

AlogP

4.93

Hydrogen Bond Acceptor

7.0

Number of Rotational Bond

7.0

Polar Surface Area

65.18

Molecular species

BASE

Aromatic Rings

4.0

Heavy Atoms

35.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family	-	0.09	-	-	-

Targets

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Enzyme Kinase Protein Kinase Atypical protein kinase group Atypical protein kinase PIKK family

0.09

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.09	-	-	-

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Homo sapiens

0.09

Resources	Reference
ChEMBL	CHEMBL4594429
FDA SRS	CI43QFE22O
Guide to Pharmacology	11277
PubChem	126689157
SureChEMBL	SCHEMBL18631972

Resources

Reference

ChEMBL

CHEMBL4594429

FDA SRS

CI43QFE22O

Guide to Pharmacology

11277

PubChem

126689157

SureChEMBL

SCHEMBL18631972

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

AZD-1390

Structure

Physicochemical Descriptors

Pharmacology

Cross References