PD-0166285


InChI Key	IFPPYSWJNWHOLQ-UHFFFAOYSA-N
Smiles	CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
InChI	InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)

Mechanism of Action	Action	Reference
Epidermal growth factor receptor erbB1 inhibitor	INHIBITOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase WEE family Other protein kinase WEE1	-	-	5	-	-
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase WEE family	-	7-165	11-247	0.8-2	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase EGFR family	-	350	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	43-44	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	1.8-96	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family	-	9-9	-	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase RIPK family	-	13	-	-	-
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase STKR family TKL protein kinase STKR1	-	21	-	-	-
Transcription factor	-	7.2	-	-	-
Unclassified protein	-	37	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Aves	-	9	-	-	-
Gallus gallus	-	9	-	-	-
Homo sapiens	-	7-520	5-247	0.8-2	-
Mus musculus	-	1.1-350	-	-	-
Rattus norvegicus	-	5-340	-	-	-


Protein: Epidermal growth factor receptor erbB1 Description: Epidermal growth factor receptor Organism : Homo sapiens P00533 ENSG00000146648












Protein: Platelet-derived growth factor receptor beta Description: Platelet-derived growth factor receptor beta Organism : Homo sapiens P09619 ENSG00000113721











Protein: Fibroblast growth factor receptor 1 Description: Fibroblast growth factor receptor 1 Organism : Homo sapiens P11362 ENSG00000077782












Protein: Tyrosine-protein kinase SRC Description: Proto-oncogene tyrosine-protein kinase Src Organism : Homo sapiens P12931 ENSG00000197122

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