AZD6280

/static/temp/default.svg

Search structure


Synonyms	Azd-6280 Azd6280
Status
Molecule Category	Free-form
UNII	B9Z1OEH19D

Structure


InChI Key	NVWCZRPXYVDQEE-UHFFFAOYSA-N
Smiles	CCCNC(=O)c1nnc2c(-c3cc(OC)ccc3OC)cccc2c1N
InChI	InChI=1S/C20H22N4O3/c1-4-10-22-20(25)19-17(21)14-7-5-6-13(18(14)23-24-19)15-11-12(26-2)8-9-16(15)27-3/h5-9,11H,4,10H2,1-3H3,(H2,21,23)(H,22,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C20H22N4O3
Molecular Weight	366.42
AlogP	3.04
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	99.36
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	27.0

Pharmacology

Mechanism of Action	Action	Reference
GABA receptor alpha-2 subunit positive allosteric modulator	POSITIVE ALLOSTERIC MODULATOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor	-	-	-	0.5-19.95	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	0.5-15.14	-

Target Conservation


Protein: GABA receptor alpha-3 subunit Description: Gamma-aminobutyric acid receptor subunit alpha-3 Organism : Homo sapiens P34903 ENSG00000011677











Protein: GABA receptor alpha-2 subunit Description: Gamma-aminobutyric acid receptor subunit alpha-2 Organism : Homo sapiens P47869 ENSG00000151834

Related Entries

Cross References

Resources	Reference
ChEMBL	CHEMBL1783256
DrugBank	DB12210
FDA SRS	B9Z1OEH19D
SureChEMBL	SCHEMBL1962946
ZINC	ZINC000071295757

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025