EcoDrugPlus


Synonyms	AZD-0914 AZD0914 ETX-0914 ETX0914 Zoliflodacin
Status
Molecule Category	Free-form
UNII	FWL2263R77

Synonyms

AZD-0914

AZD0914

ETX-0914

ETX0914

Zoliflodacin

Status

Molecule Category

Free-form

UNII

FWL2263R77


InChI Key	ZSWMIFNWDQEXDT-ZESJGQACSA-N
Smiles	C[C@@H]1CN2c3c(cc4c(N5C(=O)OC[C@@H]5C)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1
InChI	InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1

InChI Key

ZSWMIFNWDQEXDT-ZESJGQACSA-N

Smiles

C[C@@H]1CN2c3c(cc4c(N5C(=O)OC[C@@H]5C)noc4c3F)CC3(C(=O)NC(=O)NC3=O)[C@H]2[C@H](C)O1

InChI

InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1

Property Name	Value
Molecular Formula	C22H22FN5O7
Molecular Weight	487.44
AlogP	1.2
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	143.31
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	35.0

Property Name

Value

Molecular Formula

C22H22FN5O7

Molecular Weight

487.44

AlogP

1.2

Hydrogen Bond Acceptor

9.0

Hydrogen Bond Donor

2.0

Number of Rotational Bond

1.0

Polar Surface Area

143.31

Molecular species

NEUTRAL

Aromatic Rings

2.0

Heavy Atoms

35.0

Mechanism of Action	Action	Reference
DNA gyrase inhibitor	INHIBITOR	PubMed

Mechanism of Action

Action

Reference

DNA gyrase inhibitor

INHIBITOR

PubMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Escherichia coli	-	170	-	-	-

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Escherichia coli

170

Resources	Reference
ChEMBL	CHEMBL3544978
DrugBank	DB12817
FDA SRS	FWL2263R77
Guide to Pharmacology	10875
PubChem	76685216
SureChEMBL	SCHEMBL15879500

Resources

Reference

ChEMBL

CHEMBL3544978

DrugBank

DB12817

FDA SRS

FWL2263R77

Guide to Pharmacology

10875

PubChem

76685216

SureChEMBL

SCHEMBL15879500

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

ZOLIFLODACIN

Structure

Physicochemical Descriptors

Pharmacology

Cross References