PF-04217903

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Synonyms
Status
Molecule Category Free-form
UNII CYJ9ATV1IJ

Structure

InChI Key PDMUGYOXRHVNMO-UHFFFAOYSA-N
Smiles OCCn1cc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1
InChI
InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H16N8O
Molecular Weight 372.39
AlogP 1.67
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 5.0
Polar Surface Area 107.43
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 28.0

Pharmacology

Mechanism of Action Action Reference
Hepatocyte growth factor receptor inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
0.3 4-50.12 - 5 -
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A
- - - - 71
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B
- - - - 71
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4A
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4C
- - - - 44
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D
- - - - 44
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - - 33
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
0.3 4-50.12 - 5 16-71

Target Conservation

Protein: Hepatocyte growth factor receptor
Description: Hepatocyte growth factor receptor
Organism : Homo sapiens
P08581 ENSG00000105976

Related Entries

Cross References

Resources Reference
ChEBI 91425
ChEMBL CHEMBL2001019
DrugBank DB12848
FDA SRS CYJ9ATV1IJ
PDB KRW
PubChem 17754438
SureChEMBL SCHEMBL93550
ZINC ZINC000043195316
CONTENTS