CYPROHEPTADINE HYDROCHLORIDE

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Trade Names	CYPROHEPTADINE HYDROCHLORIDE PERIACTIN
Synonyms	Cyproheptadine HCl Cyproheptadine Hydrocloride Cyproheptadine hcl Cyproheptadine hydrochloride Cyproheptadine hydrochloride hydrate Cyproheptadine hydrochloride sesquihydrate NSC-169911 NSC-759282 Periactin Periactine Peritol
Status
Molecule Category	Salt-form
UNII	0S9323MCT0
EPA CompTox	DTXSID5042586
Parent Compound:	CYPROHEPTADINE

Structure


InChI Key	ZPMVNZLARAEGHB-UHFFFAOYSA-N
Smiles	CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1.Cl
InChI	InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H22ClN
Molecular Weight	323.87
AlogP	4.7
Hydrogen Bond Acceptor	1.0
Polar Surface Area	3.24
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Histamine H1 receptor antagonist	ANTAGONIST	ISBN

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Rattus norvegicus	-	-	-	-	23-93

Target Conservation


Protein: Histamine H1 receptor Description: Histamine H1 receptor Organism : Homo sapiens P35367 ENSG00000196639

Cross References

Resources	Reference
ChEBI	59695
ChEMBL	CHEMBL1716
FDA SRS	0S9323MCT0
Guide to Pharmacology	277
KEGG	C06935
PubChem	11954233
SureChEMBL	SCHEMBL41842
ZINC	ZINC00968264

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025