Gene: CHEK1
Ensembl ID : ENSG00000149554
Description: checkpoint kinase 1
Gene Synonyms: CHK1
10 APIs:
179 Possible Orthologues:

Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) R-HSA-5685942
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of TP53 Activity R-HSA-5633007
Signaling by SCF-KIT R-HSA-1433557
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G2/M Checkpoints R-HSA-69481
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
G1/S DNA Damage Checkpoints R-HSA-69615
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Homology Directed Repair R-HSA-5693538
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cell Cycle R-HSA-1640170
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) R-HSA-5685942
G2/M DNA damage checkpoint R-HSA-69473
DNA Double-Strand Break Repair R-HSA-5693532
Processing of DNA double-strand break ends R-HSA-5693607
G2/M Checkpoints R-HSA-69481
Transcriptional Regulation by E2F6 R-HSA-8953750
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Homology Directed Repair R-HSA-5693538
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
p53-Independent DNA Damage Response R-HSA-69610
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
DNA Repair R-HSA-73894
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by SCF-KIT R-HSA-1433557
Activation of ATR in response to replication stress R-HSA-176187
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Gene expression (Transcription) R-HSA-74160
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
p53-Independent DNA Damage Response R-HSA-69610
Signaling by SCF-KIT R-HSA-1433557
G1/S DNA Damage Checkpoints R-HSA-69615
Processing of DNA double-strand break ends R-HSA-5693607
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Homology Directed Repair R-HSA-5693538
RNA Polymerase II Transcription R-HSA-73857
G2/M DNA damage checkpoint R-HSA-69473
HDR through Homologous Recombination (HRR) R-HSA-5685942
DNA Double-Strand Break Repair R-HSA-5693532
Signal Transduction R-HSA-162582
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M Checkpoints R-HSA-69481
DNA Repair R-HSA-73894
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of TP53 Activity R-HSA-5633007
Activation of ATR in response to replication stress R-HSA-176187
DNA Repair R-HSA-73894
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Activation of ATR in response to replication stress R-HSA-176187
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) R-HSA-5685942
Homology Directed Repair R-HSA-5693538
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M DNA damage checkpoint R-HSA-69473
DNA Double-Strand Break Repair R-HSA-5693532
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity R-HSA-5633007
Signaling by SCF-KIT R-HSA-1433557
G2/M Checkpoints R-HSA-69481
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Cell Cycle R-HSA-1640170
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle R-HSA-1640170
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Signal Transduction R-HSA-162582
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
G1/S DNA Damage Checkpoints R-HSA-69615
Cell Cycle Checkpoints R-HSA-69620
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
Homology Directed Repair R-HSA-5693538
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
Signaling by SCF-KIT R-HSA-1433557
Activation of ATR in response to replication stress R-HSA-176187
HDR through Homologous Recombination (HRR) R-HSA-5685942
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity R-HSA-5633007
Gene expression (Transcription) R-HSA-74160
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
G2/M Checkpoints R-HSA-69481
p53-Independent DNA Damage Response R-HSA-69610
Signal Transduction R-HSA-162582
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle R-HSA-1640170
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by SCF-KIT R-HSA-1433557
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Processing of DNA double-strand break ends R-HSA-5693607
DNA Repair R-HSA-73894
Activation of ATR in response to replication stress R-HSA-176187
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Generic Transcription Pathway R-HSA-212436
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) R-HSA-5685942
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G1/S DNA Damage Checkpoints R-HSA-69615
G2/M Checkpoints R-HSA-69481
Gene expression (Transcription) R-HSA-74160
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
Processing of DNA double-strand break ends R-HSA-5693607
Transcriptional Regulation by E2F6 R-HSA-8953750
DNA Repair R-HSA-73894
Cell Cycle Checkpoints R-HSA-69620
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
Generic Transcription Pathway R-HSA-212436
p53-Independent DNA Damage Response R-HSA-69610
HDR through Homologous Recombination (HRR) R-HSA-5685942
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
G1/S DNA Damage Checkpoints R-HSA-69615
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity R-HSA-5633007
G2/M DNA damage checkpoint R-HSA-69473
Signaling by SCF-KIT R-HSA-1433557
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homology Directed Repair R-HSA-5693538
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cell Cycle R-HSA-1640170
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by SCF-KIT R-HSA-1433557
Transcriptional Regulation by TP53 R-HSA-3700989
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Transcriptional Regulation by E2F6 R-HSA-8953750
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Processing of DNA double-strand break ends R-HSA-5693607
Activation of ATR in response to replication stress R-HSA-176187
HDR through Homologous Recombination (HRR) R-HSA-5685942
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of TP53 Activity R-HSA-5633007
DNA Repair R-HSA-73894
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
Generic Transcription Pathway R-HSA-212436
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
DNA Double-Strand Break Repair R-HSA-5693532
G1/S DNA Damage Checkpoints R-HSA-69615
Signal Transduction R-HSA-162582
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Gene expression (Transcription) R-HSA-74160
DNA Repair R-HSA-73894
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Signaling by SCF-KIT R-HSA-1433557
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
HDR through Homologous Recombination (HRR) R-HSA-5685942
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G2/M DNA damage checkpoint R-HSA-69473
Activation of ATR in response to replication stress R-HSA-176187
Regulation of TP53 Activity R-HSA-5633007
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Transcriptional Regulation by E2F6 R-HSA-8953750
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
Generic Transcription Pathway R-HSA-212436
G1/S DNA Damage Checkpoints R-HSA-69615
DNA Double-Strand Break Repair R-HSA-5693532
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Cell Cycle Checkpoints R-HSA-69620
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Signal Transduction R-HSA-162582
Activation of ATR in response to replication stress R-HSA-176187
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of TP53 Activity R-HSA-5633007
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by SCF-KIT R-HSA-1433557
Transcriptional Regulation by TP53 R-HSA-3700989
Transcriptional Regulation by E2F6 R-HSA-8953750
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
DNA Repair R-HSA-73894
Processing of DNA double-strand break ends R-HSA-5693607
Homology Directed Repair R-HSA-5693538
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity R-HSA-5633007
Processing of DNA double-strand break ends R-HSA-5693607
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Cell Cycle R-HSA-1640170
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
G2/M DNA damage checkpoint R-HSA-69473
Signaling by SCF-KIT R-HSA-1433557
DNA Double-Strand Break Repair R-HSA-5693532
p53-Independent DNA Damage Response R-HSA-69610
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Transcriptional Regulation by E2F6 R-HSA-8953750
HDR through Homologous Recombination (HRR) R-HSA-5685942
Activation of ATR in response to replication stress R-HSA-176187
Signal Transduction R-HSA-162582
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Homology Directed Repair R-HSA-5693538
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G1/S DNA Damage Checkpoints R-HSA-69615

Expression Atlas ENSG00000149554
NCBI gene (formerly Entrezgene) 1111
GeneCards 1925
HGNC Symbol HGNC:1925
MIM gene 603078
UniProtKB Gene Name O14757
WikiGene 1111
Ensembl ID : ENSG00000089022
Description: MAPK activated protein kinase 5
Gene Synonyms: MK5,PRAK
1 APIs:
179 Possible Orthologues:

Signal Transduction R-HSA-162582
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
MAPK6/MAPK4 signaling R-HSA-5687128
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
MAPK family signaling cascades R-HSA-5683057
Cellular Senescence R-HSA-2559583
Signal Transduction R-HSA-162582
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
Oxidative Stress Induced Senescence R-HSA-2559580
MAPK6/MAPK4 signaling R-HSA-5687128
MAPK6/MAPK4 signaling R-HSA-5687128
Oxidative Stress Induced Senescence R-HSA-2559580
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
MAPK family signaling cascades R-HSA-5683057
Cellular responses to stimuli R-HSA-8953897
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular Senescence R-HSA-2559583
Regulation of TP53 Activity R-HSA-5633007
Regulation of TP53 Activity R-HSA-5633007
MAPK6/MAPK4 signaling R-HSA-5687128
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular responses to stress R-HSA-2262752
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Cellular responses to stimuli R-HSA-8953897
Signal Transduction R-HSA-162582
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Cellular Senescence R-HSA-2559583
RNA Polymerase II Transcription R-HSA-73857
Regulation of TP53 Activity R-HSA-5633007
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
MAPK6/MAPK4 signaling R-HSA-5687128
Signal Transduction R-HSA-162582
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
MAPK family signaling cascades R-HSA-5683057
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Generic Transcription Pathway R-HSA-212436
Cellular Senescence R-HSA-2559583
MAPK6/MAPK4 signaling R-HSA-5687128
Regulation of TP53 Activity R-HSA-5633007
MAPK family signaling cascades R-HSA-5683057
Transcriptional Regulation by TP53 R-HSA-3700989
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cellular responses to stimuli R-HSA-8953897
MAPK6/MAPK4 signaling R-HSA-5687128
Oxidative Stress Induced Senescence R-HSA-2559580
Transcriptional Regulation by TP53 R-HSA-3700989
MAPK family signaling cascades R-HSA-5683057
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular Senescence R-HSA-2559583
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stimuli R-HSA-8953897
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
MAPK6/MAPK4 signaling R-HSA-5687128
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Gene expression (Transcription) R-HSA-74160
Oxidative Stress Induced Senescence R-HSA-2559580
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
MAPK family signaling cascades R-HSA-5683057
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Gene expression (Transcription) R-HSA-74160
MAPK6/MAPK4 signaling R-HSA-5687128
Regulation of TP53 Activity R-HSA-5633007
Generic Transcription Pathway R-HSA-212436
MAPK family signaling cascades R-HSA-5683057
Oxidative Stress Induced Senescence R-HSA-2559580
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular responses to stimuli R-HSA-8953897
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cellular Senescence R-HSA-2559583
Gene expression (Transcription) R-HSA-74160
MAPK6/MAPK4 signaling R-HSA-5687128
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Regulation of TP53 Activity R-HSA-5633007
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583

Expression Atlas ENSG00000089022
NCBI gene (formerly Entrezgene) 8550
GeneCards 6889
HGNC Symbol HGNC:6889
MIM gene 606723
MIM morbid 619869
UniProtKB Gene Name R4GN93
WikiGene 8550
Gene: MKNK2
Ensembl ID : ENSG00000099875
Description: MAPK interacting serine/threonine kinase 2
Gene Synonyms: GPRK7,MNK2
1 APIs:
221 Possible Orthologues:

Expression Atlas ENSG00000099875
NCBI gene (formerly Entrezgene) 2872
GeneCards 7111
HGNC Symbol HGNC:7111
MIM gene 605069
UniProtKB Gene Name Q9NV89
WikiGene 2872
Ensembl ID : ENSG00000162889
Description: MAPK activated protein kinase 2
Gene Synonyms: MK2
1 APIs:
240 Possible Orthologues:

Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism R-HSA-1430728
Immune System R-HSA-168256
MyD88 dependent cascade initiated on endosome R-HSA-975155
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Cellular responses to stress R-HSA-2262752
Oxidative Stress Induced Senescence R-HSA-2559580
Interleukin-17 signaling R-HSA-448424
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Fatty acid metabolism R-HSA-8978868
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
MAP kinase activation R-HSA-450294
CREB phosphorylation R-HSA-199920
Signalling to RAS R-HSA-167044
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Death Receptor Signaling R-HSA-73887
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Metabolism of lipids R-HSA-556833
Signaling by NTRK1 (TRKA) R-HSA-187037
Cellular Senescence R-HSA-2559583
Cytokine Signaling in Immune system R-HSA-1280215
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Metabolism of RNA R-HSA-8953854
Innate Immune System R-HSA-168249
MyD88-independent TLR4 cascade R-HSA-166166
Cellular response to heat stress R-HSA-3371556
TNF signaling R-HSA-75893
Arachidonic acid metabolism R-HSA-2142753
p38MAPK events R-HSA-171007
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Cellular responses to stimuli R-HSA-8953897
Signalling to ERKs R-HSA-187687
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by VEGF R-HSA-194138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Regulation of TNFR1 signaling R-HSA-5357905
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signal Transduction R-HSA-162582
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Signaling by NTRKs R-HSA-166520
Metabolism R-HSA-1430728
Toll-like Receptor Cascades R-HSA-168898
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
VEGFA-VEGFR2 Pathway R-HSA-4420097
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
MyD88 dependent cascade initiated on endosome R-HSA-975155
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Cellular responses to stimuli R-HSA-8953897
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signalling to RAS R-HSA-167044
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
MAP kinase activation R-HSA-450294
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by VEGF R-HSA-194138
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Death Receptor Signaling R-HSA-73887
Innate Immune System R-HSA-168249
Signalling to ERKs R-HSA-187687
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Fatty acid metabolism R-HSA-8978868
Arachidonic acid metabolism R-HSA-2142753
TNF signaling R-HSA-75893
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Interleukin-17 signaling R-HSA-448424
Immune System R-HSA-168256
MyD88 cascade initiated on plasma membrane R-HSA-975871
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Metabolism of RNA R-HSA-8953854
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Cellular response to heat stress R-HSA-3371556
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
p38MAPK events R-HSA-171007
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Metabolism of lipids R-HSA-556833
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Oxidative Stress Induced Senescence R-HSA-2559580
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Regulation of TNFR1 signaling R-HSA-5357905
Signaling by Interleukins R-HSA-449147
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
CREB phosphorylation R-HSA-199920
Signaling by Interleukins R-HSA-449147
Regulation of TNFR1 signaling R-HSA-5357905
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Immune System R-HSA-168256
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Cytokine Signaling in Immune system R-HSA-1280215
Oxidative Stress Induced Senescence R-HSA-2559580
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Interleukin-17 signaling R-HSA-448424
Metabolism of lipids R-HSA-556833
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Metabolism of RNA R-HSA-8953854
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Metabolism R-HSA-1430728
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Cellular responses to stimuli R-HSA-8953897
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by NTRK1 (TRKA) R-HSA-187037
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling by VEGF R-HSA-194138
MAP kinase activation R-HSA-450294
VEGFA-VEGFR2 Pathway R-HSA-4420097
MyD88 dependent cascade initiated on endosome R-HSA-975155
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Signalling to ERKs R-HSA-187687
Signal Transduction R-HSA-162582
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
p38MAPK events R-HSA-171007
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Innate Immune System R-HSA-168249
Cellular Senescence R-HSA-2559583
Signaling by NTRKs R-HSA-166520
Cellular response to heat stress R-HSA-3371556
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Arachidonic acid metabolism R-HSA-2142753
Cellular responses to stress R-HSA-2262752
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll-like Receptor Cascades R-HSA-168898
Fatty acid metabolism R-HSA-8978868
CREB phosphorylation R-HSA-199920
Death Receptor Signaling R-HSA-73887
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TNF signaling R-HSA-75893
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signalling to RAS R-HSA-167044
Cellular Senescence R-HSA-2559583
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
Toll-like Receptor Cascades R-HSA-168898
Arachidonic acid metabolism R-HSA-2142753
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88-independent TLR4 cascade R-HSA-166166
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Metabolism of RNA R-HSA-8953854
Signaling by NTRK1 (TRKA) R-HSA-187037
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Immune System R-HSA-168256
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Oxidative Stress Induced Senescence R-HSA-2559580
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
MAP kinase activation R-HSA-450294
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by NTRKs R-HSA-166520
p38MAPK events R-HSA-171007
CREB phosphorylation R-HSA-199920
Fatty acid metabolism R-HSA-8978868
Signaling by VEGF R-HSA-194138
Regulation of TNFR1 signaling R-HSA-5357905
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Cellular responses to stress R-HSA-2262752
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
TNF signaling R-HSA-75893
MyD88 dependent cascade initiated on endosome R-HSA-975155
Cellular responses to stimuli R-HSA-8953897
Cellular response to heat stress R-HSA-3371556
Signal Transduction R-HSA-162582
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Interleukin-17 signaling R-HSA-448424
Death Receptor Signaling R-HSA-73887
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
MyD88 cascade initiated on plasma membrane R-HSA-975871
Metabolism of lipids R-HSA-556833
Signalling to ERKs R-HSA-187687
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
VEGFA-VEGFR2 Pathway R-HSA-4420097
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signalling to RAS R-HSA-167044
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism R-HSA-1430728
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TNF signaling R-HSA-75893
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Immune System R-HSA-168256
Toll-like Receptor Cascades R-HSA-168898
Signaling by NTRKs R-HSA-166520
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signalling to ERKs R-HSA-187687
Arachidonic acid metabolism R-HSA-2142753
Cellular Senescence R-HSA-2559583
Regulation of TNFR1 signaling R-HSA-5357905
Cellular responses to stress R-HSA-2262752
VEGFA-VEGFR2 Pathway R-HSA-4420097
Interleukin-17 signaling R-HSA-448424
Signaling by NTRK1 (TRKA) R-HSA-187037
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Fatty acid metabolism R-HSA-8978868
Signaling by Interleukins R-HSA-449147
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Cellular response to heat stress R-HSA-3371556
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signal Transduction R-HSA-162582
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Oxidative Stress Induced Senescence R-HSA-2559580
MyD88 dependent cascade initiated on endosome R-HSA-975155
Cellular responses to stimuli R-HSA-8953897
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Innate Immune System R-HSA-168249
Metabolism of RNA R-HSA-8953854
Signalling to RAS R-HSA-167044
Death Receptor Signaling R-HSA-73887
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
CREB phosphorylation R-HSA-199920
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MAP kinase activation R-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Signaling by VEGF R-HSA-194138
Cytokine Signaling in Immune system R-HSA-1280215
p38MAPK events R-HSA-171007
Regulation of HSF1-mediated heat shock response R-HSA-3371453
MyD88-independent TLR4 cascade R-HSA-166166
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular response to heat stress R-HSA-3371556
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Innate Immune System R-HSA-168249
MyD88 dependent cascade initiated on endosome R-HSA-975155
Arachidonic acid metabolism R-HSA-2142753
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
TNF signaling R-HSA-75893
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRKs R-HSA-166520
VEGFA-VEGFR2 Pathway R-HSA-4420097
Metabolism R-HSA-1430728
Fatty acid metabolism R-HSA-8978868
Cellular responses to stress R-HSA-2262752
Death Receptor Signaling R-HSA-73887
Signaling by VEGF R-HSA-194138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
p38MAPK events R-HSA-171007
Signalling to RAS R-HSA-167044
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Cellular Senescence R-HSA-2559583
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAP kinase activation R-HSA-450294
Regulation of TNFR1 signaling R-HSA-5357905
Signal Transduction R-HSA-162582
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88 cascade initiated on plasma membrane R-HSA-975871
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Metabolism of lipids R-HSA-556833
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signalling to ERKs R-HSA-187687
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Cellular responses to stimuli R-HSA-8953897
CREB phosphorylation R-HSA-199920
Metabolism of RNA R-HSA-8953854
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Cellular responses to stress R-HSA-2262752
MAP kinase activation R-HSA-450294
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signalling to ERKs R-HSA-187687
Metabolism of lipids R-HSA-556833
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Innate Immune System R-HSA-168249
Interleukin-17 signaling R-HSA-448424
Signaling by NTRKs R-HSA-166520
Death Receptor Signaling R-HSA-73887
Cellular response to heat stress R-HSA-3371556
Signal Transduction R-HSA-162582
MyD88 dependent cascade initiated on endosome R-HSA-975155
Cellular responses to stimuli R-HSA-8953897
Signaling by VEGF R-HSA-194138
Cellular Senescence R-HSA-2559583
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Fatty acid metabolism R-HSA-8978868
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Interleukins R-HSA-449147
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Immune System R-HSA-168256
Signalling to RAS R-HSA-167044
MyD88-independent TLR4 cascade R-HSA-166166
Metabolism of RNA R-HSA-8953854
Oxidative Stress Induced Senescence R-HSA-2559580
p38MAPK events R-HSA-171007
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
VEGFA-VEGFR2 Pathway R-HSA-4420097
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Metabolism R-HSA-1430728
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll-like Receptor Cascades R-HSA-168898
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Arachidonic acid metabolism R-HSA-2142753
Regulation of TNFR1 signaling R-HSA-5357905
CREB phosphorylation R-HSA-199920
TNF signaling R-HSA-75893
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Cellular responses to stimuli R-HSA-8953897
Signaling by VEGF R-HSA-194138
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signal Transduction R-HSA-162582
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Innate Immune System R-HSA-168249
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Metabolism of lipids R-HSA-556833
Signaling by NTRKs R-HSA-166520
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Interleukin-17 signaling R-HSA-448424
TNF signaling R-HSA-75893
Fatty acid metabolism R-HSA-8978868
Signaling by NTRK1 (TRKA) R-HSA-187037
Signalling to RAS R-HSA-167044
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
VEGFA-VEGFR2 Pathway R-HSA-4420097
MyD88-independent TLR4 cascade R-HSA-166166
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Signalling to ERKs R-HSA-187687
MAP kinase activation R-HSA-450294
MyD88 dependent cascade initiated on endosome R-HSA-975155
Metabolism R-HSA-1430728
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Death Receptor Signaling R-HSA-73887
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Cellular response to heat stress R-HSA-3371556
Arachidonic acid metabolism R-HSA-2142753
p38MAPK events R-HSA-171007
Toll-like Receptor Cascades R-HSA-168898
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Regulation of HSF1-mediated heat shock response R-HSA-3371453
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Cytokine Signaling in Immune system R-HSA-1280215
Metabolism of RNA R-HSA-8953854
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Cellular Senescence R-HSA-2559583
Immune System R-HSA-168256
CREB phosphorylation R-HSA-199920
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Regulation of TNFR1 signaling R-HSA-5357905
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Cellular responses to stress R-HSA-2262752
Oxidative Stress Induced Senescence R-HSA-2559580
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
Signaling by Interleukins R-HSA-449147
MyD88 dependent cascade initiated on endosome R-HSA-975155
Immune System R-HSA-168256
Toll-like Receptor Cascades R-HSA-168898
Regulation of TNFR1 signaling R-HSA-5357905
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Cellular responses to stimuli R-HSA-8953897
Metabolism R-HSA-1430728
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
p38MAPK events R-HSA-171007
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Metabolism of lipids R-HSA-556833
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Arachidonic acid metabolism R-HSA-2142753
Cellular Senescence R-HSA-2559583
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Signaling by NTRK1 (TRKA) R-HSA-187037
Cellular response to heat stress R-HSA-3371556
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Death Receptor Signaling R-HSA-73887
Cellular responses to stress R-HSA-2262752
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signalling to RAS R-HSA-167044
Oxidative Stress Induced Senescence R-HSA-2559580
MyD88 cascade initiated on plasma membrane R-HSA-975871
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
MAP kinase activation R-HSA-450294
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signal Transduction R-HSA-162582
Cytokine Signaling in Immune system R-HSA-1280215
Signalling to ERKs R-HSA-187687
Fatty acid metabolism R-HSA-8978868
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
Signaling by VEGF R-HSA-194138
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
TNF signaling R-HSA-75893
Metabolism of RNA R-HSA-8953854
CREB phosphorylation R-HSA-199920
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Arachidonic acid metabolism R-HSA-2142753
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Immune System R-HSA-168256
VEGFA-VEGFR2 Pathway R-HSA-4420097
Oxidative Stress Induced Senescence R-HSA-2559580
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Death Receptor Signaling R-HSA-73887
MAP kinase activation R-HSA-450294
Signaling by NTRK1 (TRKA) R-HSA-187037
Signalling to ERKs R-HSA-187687
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
CREB phosphorylation R-HSA-199920
Signaling by NTRKs R-HSA-166520
Cellular response to heat stress R-HSA-3371556
Toll-like Receptor Cascades R-HSA-168898
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-450385
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Cellular responses to stress R-HSA-2262752
MyD88-independent TLR4 cascade R-HSA-166166
TNF signaling R-HSA-75893
MyD88 dependent cascade initiated on endosome R-HSA-975155
Regulation of TNFR1 signaling R-HSA-5357905
Cellular responses to stimuli R-HSA-8953897
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
p38MAPK events R-HSA-171007
activated TAK1 mediates p38 MAPK activation R-HSA-450302
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Metabolism R-HSA-1430728
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA R-HSA-450513
Interleukin-17 signaling R-HSA-448424
MyD88 cascade initiated on plasma membrane R-HSA-975871
Metabolism of RNA R-HSA-8953854
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by VEGF R-HSA-194138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Cytokine Signaling in Immune system R-HSA-1280215
Innate Immune System R-HSA-168249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Cellular Senescence R-HSA-2559583
Signalling to RAS R-HSA-167044
Signal Transduction R-HSA-162582
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164

Expression Atlas ENSG00000162889
NCBI gene (formerly Entrezgene) 9261
GeneCards 6887
HGNC Symbol HGNC:6887
MIM gene 602006
UniProtKB Gene Name P49137
WikiGene 9261
Gene: MKNK1
Ensembl ID : ENSG00000079277
Description: MAPK interacting serine/threonine kinase 1
Gene Synonyms: MNK1
1 APIs:
168 Possible Orthologues:

Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR4 R-HSA-5654743
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR2 signaling R-HSA-5654727
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR1 R-HSA-5654736
Signaling by FGFR2 R-HSA-5654738
Signaling by FGFR R-HSA-190236
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR1 R-HSA-5654736
Signal Transduction R-HSA-162582
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR3 signaling R-HSA-5654732
Spry regulation of FGF signaling R-HSA-1295596
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Signal Transduction R-HSA-162582
Signaling by FGFR2 R-HSA-5654738
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR2 signaling R-HSA-5654727
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR4 R-HSA-5654743
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR1 R-HSA-5654736
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR3 signaling R-HSA-5654732
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR R-HSA-190236
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR2 signaling R-HSA-5654727
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR R-HSA-190236
Signal Transduction R-HSA-162582
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR R-HSA-190236
Signaling by FGFR1 R-HSA-5654736
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR2 signaling R-HSA-5654727
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR1 signaling R-HSA-5654726
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR4 R-HSA-5654743
Spry regulation of FGF signaling R-HSA-1295596
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR R-HSA-190236
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR4 R-HSA-5654743
Negative regulation of FGFR1 signaling R-HSA-5654726

Expression Atlas ENSG00000079277
NCBI gene (formerly Entrezgene) 8569
GeneCards 7110
HGNC Symbol HGNC:7110
MIM gene 606724
UniProtKB Gene Name Q9BUB5
WikiGene 8569
Gene: PIM3
Ensembl ID : ENSG00000198355
Description: Pim-3 proto-oncogene, serine/threonine kinase
Gene Synonyms:
3 APIs:
196 Possible Orthologues:

Expression Atlas ENSG00000198355
NCBI gene (formerly Entrezgene) 415116
GeneCards 19310
HGNC Symbol HGNC:19310
MIM gene 610580
UniProtKB Gene Name Q86V86
WikiGene 415116
Gene: PIM1
Ensembl ID : ENSG00000137193
Description: Pim-1 proto-oncogene, serine/threonine kinase
Gene Synonyms: PIM
3 APIs:
248 Possible Orthologues:

Disease R-HSA-1643685
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by FLT3 fusion proteins R-HSA-9703465
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
FLT3 signaling in disease R-HSA-9682385
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Disease R-HSA-1643685
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Signaling by FLT3 fusion proteins R-HSA-9703465
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
FLT3 signaling in disease R-HSA-9682385
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Interleukins R-HSA-449147
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Disease R-HSA-1643685
FLT3 signaling in disease R-HSA-9682385
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Immune System R-HSA-168256
Signaling by FLT3 fusion proteins R-HSA-9703465
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Immune System R-HSA-168256
Signaling by Interleukins R-HSA-449147
FLT3 signaling in disease R-HSA-9682385
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Signaling by FLT3 fusion proteins R-HSA-9703465
FLT3 signaling in disease R-HSA-9682385
Signaling by Interleukins R-HSA-449147
Disease R-HSA-1643685
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Immune System R-HSA-168256
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cytokine Signaling in Immune system R-HSA-1280215
Disease R-HSA-1643685
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Signaling by Interleukins R-HSA-449147
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by FLT3 fusion proteins R-HSA-9703465
Immune System R-HSA-168256
FLT3 signaling in disease R-HSA-9682385
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Interleukins R-HSA-449147
FLT3 signaling in disease R-HSA-9682385
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cytokine Signaling in Immune system R-HSA-1280215
Immune System R-HSA-168256
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Disease R-HSA-1643685
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Signaling by FLT3 fusion proteins R-HSA-9703465
Immune System R-HSA-168256
FLT3 signaling in disease R-HSA-9682385
Disease R-HSA-1643685
Signaling by FLT3 fusion proteins R-HSA-9703465
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
STAT5 activation downstream of FLT3 ITD mutants R-HSA-9702518
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Interleukins R-HSA-449147

Expression Atlas ENSG00000137193
NCBI gene (formerly Entrezgene) 5292
GeneCards 8986
HGNC Symbol HGNC:8986
MIM gene 164960
UniProtKB Gene Name P11309
WikiGene 5292
Gene: PIM2
Ensembl ID : ENSG00000102096
Description: Pim-2 proto-oncogene, serine/threonine kinase
Gene Synonyms:
3 APIs:
115 Possible Orthologues:

Expression Atlas ENSG00000102096
NCBI gene (formerly Entrezgene) 11040
GeneCards 8987
HGNC Symbol HGNC:8987
MIM gene 300295
UniProtKB Gene Name Q9P1W9
WikiGene 11040