Gene: NPM1
Ensembl ID : ENSG00000181163
Description: nucleophosmin 1
Gene Synonyms: B23,NPM
2 APIs:
158 Possible Orthologues:

Chromosome Maintenance R-HSA-73886
SARS-CoV-1 Infection R-HSA-9678108
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Nucleosome assembly R-HSA-774815
Interactions of Rev with host cellular proteins R-HSA-177243
Post-translational protein modification R-HSA-597592
RNA Polymerase II Transcription R-HSA-73857
ALK mutants bind TKIs R-HSA-9700645
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle R-HSA-1640170
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
Infectious disease R-HSA-5663205
Generic Transcription Pathway R-HSA-212436
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SARS-CoV-1-host interactions R-HSA-9692914
HIV Infection R-HSA-162906
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Host Interactions of HIV factors R-HSA-162909
SUMOylation R-HSA-2990846
Metabolism of proteins R-HSA-392499
SUMOylation of transcription cofactors R-HSA-3899300
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK in cancer R-HSA-9700206
Gene expression (Transcription) R-HSA-74160
SARS-CoV Infections R-HSA-9679506
Nuclear import of Rev protein R-HSA-180746
RNA Polymerase II Transcription R-HSA-73857
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
SARS-CoV-1-host interactions R-HSA-9692914
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle R-HSA-1640170
Interactions of Rev with host cellular proteins R-HSA-177243
HIV Infection R-HSA-162906
SARS-CoV-1 Infection R-HSA-9678108
Chromosome Maintenance R-HSA-73886
Nucleosome assembly R-HSA-774815
Nuclear import of Rev protein R-HSA-180746
SUMOylation of transcription cofactors R-HSA-3899300
Disease R-HSA-1643685
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Generic Transcription Pathway R-HSA-212436
Signaling by ALK in cancer R-HSA-9700206
Host Interactions of HIV factors R-HSA-162909
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Post-translational protein modification R-HSA-597592
SUMOylation R-HSA-2990846
Infectious disease R-HSA-5663205
Metabolism of proteins R-HSA-392499
ALK mutants bind TKIs R-HSA-9700645
SARS-CoV Infections R-HSA-9679506
Gene expression (Transcription) R-HSA-74160
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
SUMOylation of transcription cofactors R-HSA-3899300
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Generic Transcription Pathway R-HSA-212436
SARS-CoV Infections R-HSA-9679506
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK in cancer R-HSA-9700206
Host Interactions of HIV factors R-HSA-162909
Post-translational protein modification R-HSA-597592
Chromosome Maintenance R-HSA-73886
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
HIV Infection R-HSA-162906
SUMOylation R-HSA-2990846
SARS-CoV-1 Infection R-HSA-9678108
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
Nucleosome assembly R-HSA-774815
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
Metabolism of proteins R-HSA-392499
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Signaling by ALK fusions and activated point mutants R-HSA-9725370
SARS-CoV-1-host interactions R-HSA-9692914
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Cell Cycle R-HSA-1640170
ALK mutants bind TKIs R-HSA-9700645
Nuclear import of Rev protein R-HSA-180746
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Transcriptional Regulation by TP53 R-HSA-3700989
Interactions of Rev with host cellular proteins R-HSA-177243
Cell Cycle R-HSA-1640170
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interactions of Rev with host cellular proteins R-HSA-177243
Host Interactions of HIV factors R-HSA-162909
SARS-CoV-1 Infection R-HSA-9678108
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
Signaling by ALK in cancer R-HSA-9700206
Metabolism of proteins R-HSA-392499
Nuclear import of Rev protein R-HSA-180746
RNA Polymerase II Transcription R-HSA-73857
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Nucleosome assembly R-HSA-774815
Generic Transcription Pathway R-HSA-212436
ALK mutants bind TKIs R-HSA-9700645
Post-translational protein modification R-HSA-597592
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Infectious disease R-HSA-5663205
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
SUMOylation R-HSA-2990846
SUMOylation of transcription cofactors R-HSA-3899300
Chromosome Maintenance R-HSA-73886
Gene expression (Transcription) R-HSA-74160
SARS-CoV-1-host interactions R-HSA-9692914
SARS-CoV Infections R-HSA-9679506
Transcriptional Regulation by TP53 R-HSA-3700989
HIV Infection R-HSA-162906
SARS-CoV-1-host interactions R-HSA-9692914
Generic Transcription Pathway R-HSA-212436
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Interactions of Rev with host cellular proteins R-HSA-177243
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Metabolism of proteins R-HSA-392499
SUMOylation R-HSA-2990846
Cell Cycle R-HSA-1640170
Signaling by ALK in cancer R-HSA-9700206
ALK mutants bind TKIs R-HSA-9700645
SUMOylation of transcription cofactors R-HSA-3899300
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
Chromosome Maintenance R-HSA-73886
Nuclear import of Rev protein R-HSA-180746
SARS-CoV-1 Infection R-HSA-9678108
HIV Infection R-HSA-162906
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Gene expression (Transcription) R-HSA-74160
Post-translational protein modification R-HSA-597592
Host Interactions of HIV factors R-HSA-162909
SARS-CoV Infections R-HSA-9679506
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Nucleosome assembly R-HSA-774815

Expression Atlas ENSG00000181163
LRG display in Ensembl gene LRG_458
NCBI gene (formerly Entrezgene) 4869
GeneCards 7910
HGNC Symbol HGNC:7910
MIM gene 164040
MIM morbid 601626
UniProtKB Gene Name P06748
WikiGene 4869
Gene: MAP3K13
Ensembl ID : ENSG00000073803
Description: mitogen-activated protein kinase kinase kinase 13
Gene Synonyms: LZK,MEKK13
1 APIs:
201 Possible Orthologues:

Expression Atlas ENSG00000073803
NCBI gene (formerly Entrezgene) 9175
GeneCards 6852
HGNC Symbol HGNC:6852
MIM gene 604915
UniProtKB Gene Name O43283
WikiGene 9175
Gene: ARAF
Ensembl ID : ENSG00000078061
Description: A-Raf proto-oncogene, serine/threonine kinase
Gene Synonyms: ARAF1
1 APIs:
192 Possible Orthologues:

Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Oncogenic MAPK signaling R-HSA-6802957
Signaling by MRAS-complex mutants R-HSA-9660537
Signal Transduction R-HSA-162582
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Disease R-HSA-1643685
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by RAF1 mutants R-HSA-9656223
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF activation R-HSA-5673000
RAF/MAP kinase cascade R-HSA-5673001
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative regulation of MAPK pathway R-HSA-5675221
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by RAS mutants R-HSA-6802949
MAPK family signaling cascades R-HSA-5683057
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAP2K and MAPK activation R-HSA-5674135
Signaling by RAS mutants R-HSA-6802949
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling downstream of RAS mutants R-HSA-9649948
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
RAF activation R-HSA-5673000
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAP2K and MAPK activation R-HSA-5674135
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Disease R-HSA-1643685
Signaling by RAS mutants R-HSA-6802949
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAF1 mutants R-HSA-9656223
Signaling by MRAS-complex mutants R-HSA-9660537
Negative regulation of MAPK pathway R-HSA-5675221
MAP2K and MAPK activation R-HSA-5674135
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Oncogenic MAPK signaling R-HSA-6802957
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by RAF1 mutants R-HSA-9656223
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of MAPK pathway R-HSA-5675221
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAP2K and MAPK activation R-HSA-5674135
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Oncogenic MAPK signaling R-HSA-6802957
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signal Transduction R-HSA-162582
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Oncogenic MAPK signaling R-HSA-6802957
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by MRAS-complex mutants R-HSA-9660537
MAPK family signaling cascades R-HSA-5683057
Signaling by RAF1 mutants R-HSA-9656223
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MRAS-complex mutants R-HSA-9660537
Oncogenic MAPK signaling R-HSA-6802957
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAS mutants R-HSA-6802949
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
RAF/MAP kinase cascade R-HSA-5673001
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling downstream of RAS mutants R-HSA-9649948
RAF activation R-HSA-5673000
Negative regulation of MAPK pathway R-HSA-5675221
MAPK family signaling cascades R-HSA-5683057
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF activation R-HSA-5673000
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAP2K and MAPK activation R-HSA-5674135
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
RAF/MAP kinase cascade R-HSA-5673001
MAP2K and MAPK activation R-HSA-5674135
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF activation R-HSA-5673000
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAF1 mutants R-HSA-9656223
Signal Transduction R-HSA-162582
Signaling by RAS mutants R-HSA-6802949
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of MAPK pathway R-HSA-5675221
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signal Transduction R-HSA-162582
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by RAF1 mutants R-HSA-9656223
RAF activation R-HSA-5673000
MAPK1/MAPK3 signaling R-HSA-5684996
MAP2K and MAPK activation R-HSA-5674135
Signaling by RAS mutants R-HSA-6802949
RAF/MAP kinase cascade R-HSA-5673001
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAS mutants R-HSA-6802949
Negative regulation of MAPK pathway R-HSA-5675221
RAF activation R-HSA-5673000
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948

Expression Atlas ENSG00000078061
NCBI gene (formerly Entrezgene) 369
GeneCards 646
HGNC Symbol HGNC:646
MIM gene 311010
UniProtKB Gene Name P10398
WikiGene 369
Gene: MAP3K10
Ensembl ID : ENSG00000130758
Description: mitogen-activated protein kinase kinase kinase 10
Gene Synonyms: MEKK10,MLK2,MST
1 APIs:
186 Possible Orthologues:

Expression Atlas ENSG00000130758
NCBI gene (formerly Entrezgene) 4294
GeneCards 6849
HGNC Symbol HGNC:6849
MIM gene 600137
UniProtKB Gene Name Q02779
WikiGene 4294
Gene: ACVRL1
Ensembl ID : ENSG00000139567
Description: activin A receptor like type 1
Gene Synonyms: ACVRLK1,ALK1,HHT,HHT2,ORW2
2 APIs:
358 Possible Orthologues:

Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582

Expression Atlas ENSG00000139567
LRG display in Ensembl gene LRG_543
NCBI gene (formerly Entrezgene) 94
GeneCards 175
HGNC Symbol HGNC:175
MIM gene 601284
MIM morbid 600376
UniProtKB Gene Name P37023
WikiGene 94
Gene: BRAF
Ensembl ID : ENSG00000157764
Description: B-Raf proto-oncogene, serine/threonine kinase
Gene Synonyms: BRAF-1,BRAF1
14 APIs:
211 Possible Orthologues:

Oncogenic MAPK signaling R-HSA-6802957
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF activation R-HSA-5673000
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by FGFR4 R-HSA-5654743
Negative feedback regulation of MAPK pathway R-HSA-5674499
Disease R-HSA-1643685
Negative regulation of MAPK pathway R-HSA-5675221
MAPK family signaling cascades R-HSA-5683057
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by NTRK1 (TRKA) R-HSA-187037
Negative regulation of FGFR1 signaling R-HSA-5654726
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
ARMS-mediated activation R-HSA-170984
Signaling downstream of RAS mutants R-HSA-9649948
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR2 signaling R-HSA-5654727
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by FGFR1 R-HSA-5654736
Frs2-mediated activation R-HSA-170968
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by FGFR R-HSA-190236
Signalling to ERKs R-HSA-187687
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAP2K and MAPK activation R-HSA-5674135
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR2 R-HSA-5654738
Signaling by NTRKs R-HSA-166520
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
Prolonged ERK activation events R-HSA-169893
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR2 R-HSA-5654738
Signaling by RAS mutants R-HSA-6802949
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by FGFR1 R-HSA-5654736
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAF1 mutants R-HSA-9656223
Negative feedback regulation of MAPK pathway R-HSA-5674499
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by NTRK1 (TRKA) R-HSA-187037
Frs2-mediated activation R-HSA-170968
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signalling to p38 via RIT and RIN R-HSA-187706
Signalling to ERKs R-HSA-187687
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by FGFR4 R-HSA-5654743
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by FGFR R-HSA-190236
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR4 signaling R-HSA-5654733
ARMS-mediated activation R-HSA-170984
Negative regulation of FGFR1 signaling R-HSA-5654726
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAP2K and MAPK activation R-HSA-5674135
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling downstream of RAS mutants R-HSA-9649948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
ARMS-mediated activation R-HSA-170984
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR R-HSA-190236
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
RAF activation R-HSA-5673000
Signaling by RAS mutants R-HSA-6802949
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by FGFR4 R-HSA-5654743
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by FGFR3 R-HSA-5654741
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAPK family signaling cascades R-HSA-5683057
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR1 R-HSA-5654736
Signaling by NTRKs R-HSA-166520
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative regulation of FGFR4 signaling R-HSA-5654733
Prolonged ERK activation events R-HSA-169893
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR2 R-HSA-5654738
Oncogenic MAPK signaling R-HSA-6802957
Signalling to p38 via RIT and RIN R-HSA-187706
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
Negative regulation of FGFR2 signaling R-HSA-5654727
RAF activation R-HSA-5673000
Signaling by FGFR2 R-HSA-5654738
Signaling by FGFR4 R-HSA-5654743
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signalling to ERKs R-HSA-187687
ARMS-mediated activation R-HSA-170984
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAF1 mutants R-HSA-9656223
Signaling by NTRKs R-HSA-166520
Signaling by FGFR3 R-HSA-5654741
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative regulation of FGFR2 signaling R-HSA-5654727
Frs2-mediated activation R-HSA-170968
Disease R-HSA-1643685
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Spry regulation of FGF signaling R-HSA-1295596
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by FGFR1 R-HSA-5654736
Signal Transduction R-HSA-162582
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling downstream of RAS mutants R-HSA-9649948
Prolonged ERK activation events R-HSA-169893
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by RAS mutants R-HSA-6802949
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR2 signaling R-HSA-5654727
Negative regulation of FGFR3 signaling R-HSA-5654732
RAF/MAP kinase cascade R-HSA-5673001
Negative feedback regulation of MAPK pathway R-HSA-5674499
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
ARMS-mediated activation R-HSA-170984
RAF activation R-HSA-5673000
Signaling by FGFR1 R-HSA-5654736
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Spry regulation of FGF signaling R-HSA-1295596
Prolonged ERK activation events R-HSA-169893
Signalling to ERKs R-HSA-187687
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAS mutants R-HSA-6802949
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by NTRKs R-HSA-166520
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
Signaling downstream of RAS mutants R-HSA-9649948
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR R-HSA-190236
Signaling by NTRK1 (TRKA) R-HSA-187037
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
Signaling by FGFR3 R-HSA-5654741
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by MRAS-complex mutants R-HSA-9660537
Negative regulation of FGFR4 signaling R-HSA-5654733
RAF/MAP kinase cascade R-HSA-5673001
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
Signaling by FGFR1 R-HSA-5654736
Signaling downstream of RAS mutants R-HSA-9649948
Spry regulation of FGF signaling R-HSA-1295596
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR4 signaling R-HSA-5654733
ARMS-mediated activation R-HSA-170984
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by RAS mutants R-HSA-6802949
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAP2K and MAPK activation R-HSA-5674135
Signalling to p38 via RIT and RIN R-HSA-187706
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR3 R-HSA-5654741
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR R-HSA-190236
Signaling by NTRK1 (TRKA) R-HSA-187037
Negative regulation of FGFR3 signaling R-HSA-5654732
Negative feedback regulation of MAPK pathway R-HSA-5674499
Frs2-mediated activation R-HSA-170968
Signaling by FGFR4 R-HSA-5654743
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
RAF activation R-HSA-5673000
Signaling by RAF1 mutants R-HSA-9656223
Oncogenic MAPK signaling R-HSA-6802957
Signalling to ERKs R-HSA-187687
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of FGFR4 signaling R-HSA-5654733
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by FGFR1 R-HSA-5654736
ARMS-mediated activation R-HSA-170984
Negative regulation of MAPK pathway R-HSA-5675221
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by FGFR R-HSA-190236
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR3 signaling R-HSA-5654732
Frs2-mediated activation R-HSA-170968
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Disease R-HSA-1643685
Signaling by FGFR2 R-HSA-5654738
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR1 signaling R-HSA-5654726
RAF activation R-HSA-5673000
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR2 signaling R-HSA-5654727
RAF/MAP kinase cascade R-HSA-5673001
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling downstream of RAS mutants R-HSA-9649948
MAP2K and MAPK activation R-HSA-5674135
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Spry regulation of FGF signaling R-HSA-1295596
Signaling by NTRK1 (TRKA) R-HSA-187037
Prolonged ERK activation events R-HSA-169893
Signaling by RAS mutants R-HSA-6802949
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAF1 mutants R-HSA-9656223
MAPK family signaling cascades R-HSA-5683057
RAF activation R-HSA-5673000
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of FGFR1 signaling R-HSA-5654726
Oncogenic MAPK signaling R-HSA-6802957
Signaling by NTRK1 (TRKA) R-HSA-187037
MAPK family signaling cascades R-HSA-5683057
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by FGFR3 R-HSA-5654741
Signaling by RAF1 mutants R-HSA-9656223
Signaling by NTRKs R-HSA-166520
Signalling to p38 via RIT and RIN R-HSA-187706
Prolonged ERK activation events R-HSA-169893
Signalling to ERKs R-HSA-187687
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling downstream of RAS mutants R-HSA-9649948
Frs2-mediated activation R-HSA-170968
RAF/MAP kinase cascade R-HSA-5673001
Signaling by BRAF and RAF1 fusions R-HSA-6802952
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by FGFR2 R-HSA-5654738
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by MRAS-complex mutants R-HSA-9660537
ARMS-mediated activation R-HSA-170984
Negative regulation of FGFR4 signaling R-HSA-5654733
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by RAS mutants R-HSA-6802949
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Disease R-HSA-1643685
Signaling by FGFR1 R-HSA-5654736
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR3 signaling R-HSA-5654732
Spry regulation of FGF signaling R-HSA-1295596
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by RAF1 mutants R-HSA-9656223
Signaling by FGFR R-HSA-190236
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
ARMS-mediated activation R-HSA-170984
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR2 signaling R-HSA-5654727
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK family signaling cascades R-HSA-5683057
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by RAS mutants R-HSA-6802949
Signaling by FGFR2 R-HSA-5654738
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Frs2-mediated activation R-HSA-170968
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by FGFR3 R-HSA-5654741
Disease R-HSA-1643685
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by NTRK1 (TRKA) R-HSA-187037
RAF activation R-HSA-5673000
Negative feedback regulation of MAPK pathway R-HSA-5674499
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signalling to ERKs R-HSA-187687
Negative regulation of FGFR3 signaling R-HSA-5654732
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR1 R-HSA-5654736
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by MRAS-complex mutants R-HSA-9660537
Oncogenic MAPK signaling R-HSA-6802957
Negative regulation of MAPK pathway R-HSA-5675221
RAF/MAP kinase cascade R-HSA-5673001
Spry regulation of FGF signaling R-HSA-1295596
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signal Transduction R-HSA-162582
Negative regulation of FGFR1 signaling R-HSA-5654726
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR4 R-HSA-5654743
Disease R-HSA-1643685
Signaling by RAS mutants R-HSA-6802949
Signaling by FGFR4 R-HSA-5654743
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by FGFR2 R-HSA-5654738
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR1 R-HSA-5654736
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAF1 mutants R-HSA-9656223
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Prolonged ERK activation events R-HSA-169893
MAPK family signaling cascades R-HSA-5683057
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR R-HSA-190236
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Negative regulation of MAPK pathway R-HSA-5675221
ARMS-mediated activation R-HSA-170984
Signalling to ERKs R-HSA-187687
Signaling by MRAS-complex mutants R-HSA-9660537
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling downstream of RAS mutants R-HSA-9649948
RAF activation R-HSA-5673000
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by NTRKs R-HSA-166520
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative regulation of FGFR3 signaling R-HSA-5654732
Frs2-mediated activation R-HSA-170968
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAP2K and MAPK activation R-HSA-5674135
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946

Expression Atlas ENSG00000157764
LRG display in Ensembl gene LRG_299
NCBI gene (formerly Entrezgene) 673
GeneCards 1097
HGNC Symbol HGNC:1097
MIM gene 164757
MIM morbid 613707
UniProtKB Gene Name P15056
WikiGene 673
Gene: ALK
Ensembl ID : ENSG00000171094
Description: ALK receptor tyrosine kinase
Gene Synonyms: ALK1,CD246
11 APIs:
195 Possible Orthologues:

ALK mutants bind TKIs R-HSA-9700645
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK R-HSA-201556
ceritinib-resistant ALK mutants R-HSA-9717323
crizotinib-resistant ALK mutants R-HSA-9717326
Signal Transduction R-HSA-162582
ASP-3026-resistant ALK mutants R-HSA-9717264
lorlatinib-resistant ALK mutants R-HSA-9717329
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
Disease R-HSA-1643685
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NVP-TAE684-resistant ALK mutants R-HSA-9717301
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK in cancer R-HSA-9700206
alectinib-resistant ALK mutants R-HSA-9717316
brigatinib-resistant ALK mutants R-HSA-9717319
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK in cancer R-HSA-9700206
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Disease R-HSA-1643685
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by ALK fusions and activated point mutants R-HSA-9725370
ASP-3026-resistant ALK mutants R-HSA-9717264
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK R-HSA-201556
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
brigatinib-resistant ALK mutants R-HSA-9717319
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ALK R-HSA-201556
crizotinib-resistant ALK mutants R-HSA-9717326
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
ASP-3026-resistant ALK mutants R-HSA-9717264
Drug resistance of ALK mutants R-HSA-9700649
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by ALK in cancer R-HSA-9700206
NVP-TAE684-resistant ALK mutants R-HSA-9717301
lorlatinib-resistant ALK mutants R-HSA-9717329
Signal Transduction R-HSA-162582
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
ALK mutants bind TKIs R-HSA-9700645
ASP-3026-resistant ALK mutants R-HSA-9717264
Disease R-HSA-1643685
brigatinib-resistant ALK mutants R-HSA-9717319
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK in cancer R-HSA-9700206
Drug resistance of ALK mutants R-HSA-9700649
Signal Transduction R-HSA-162582
NVP-TAE684-resistant ALK mutants R-HSA-9717301
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK fusions and activated point mutants R-HSA-9725370
lorlatinib-resistant ALK mutants R-HSA-9717329
Signaling by ALK R-HSA-201556
brigatinib-resistant ALK mutants R-HSA-9717319
ceritinib-resistant ALK mutants R-HSA-9717323
Signal Transduction R-HSA-162582
Signaling by ALK fusions and activated point mutants R-HSA-9725370
lorlatinib-resistant ALK mutants R-HSA-9717329
Drug resistance of ALK mutants R-HSA-9700649
alectinib-resistant ALK mutants R-HSA-9717316
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK R-HSA-201556
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ASP-3026-resistant ALK mutants R-HSA-9717264
Signaling by ALK in cancer R-HSA-9700206
crizotinib-resistant ALK mutants R-HSA-9717326
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
ALK mutants bind TKIs R-HSA-9700645
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
NVP-TAE684-resistant ALK mutants R-HSA-9717301
lorlatinib-resistant ALK mutants R-HSA-9717329
ASP-3026-resistant ALK mutants R-HSA-9717264
ceritinib-resistant ALK mutants R-HSA-9717323
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
brigatinib-resistant ALK mutants R-HSA-9717319
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
alectinib-resistant ALK mutants R-HSA-9717316
crizotinib-resistant ALK mutants R-HSA-9717326
Signaling by ALK R-HSA-201556
Signal Transduction R-HSA-162582
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK R-HSA-201556
ceritinib-resistant ALK mutants R-HSA-9717323
ASP-3026-resistant ALK mutants R-HSA-9717264
brigatinib-resistant ALK mutants R-HSA-9717319
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK in cancer R-HSA-9700206
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
crizotinib-resistant ALK mutants R-HSA-9717326
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Drug resistance of ALK mutants R-HSA-9700649
lorlatinib-resistant ALK mutants R-HSA-9717329
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signal Transduction R-HSA-162582
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
alectinib-resistant ALK mutants R-HSA-9717316
Disease R-HSA-1643685
Signaling by ALK R-HSA-201556
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ALK mutants bind TKIs R-HSA-9700645
Drug resistance of ALK mutants R-HSA-9700649
crizotinib-resistant ALK mutants R-HSA-9717326
ceritinib-resistant ALK mutants R-HSA-9717323
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Signaling by ALK in cancer R-HSA-9700206
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
ASP-3026-resistant ALK mutants R-HSA-9717264
alectinib-resistant ALK mutants R-HSA-9717316
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ALK R-HSA-201556
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
Drug resistance of ALK mutants R-HSA-9700649
lorlatinib-resistant ALK mutants R-HSA-9717329
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by ALK in cancer R-HSA-9700206
ASP-3026-resistant ALK mutants R-HSA-9717264
alectinib-resistant ALK mutants R-HSA-9717316
ceritinib-resistant ALK mutants R-HSA-9717323
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
alectinib-resistant ALK mutants R-HSA-9717316
Signaling by ALK in cancer R-HSA-9700206
ASP-3026-resistant ALK mutants R-HSA-9717264
Signal Transduction R-HSA-162582
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK R-HSA-201556
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ceritinib-resistant ALK mutants R-HSA-9717323
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
crizotinib-resistant ALK mutants R-HSA-9717326
brigatinib-resistant ALK mutants R-HSA-9717319

Expression Atlas ENSG00000171094
LRG display in Ensembl gene LRG_488
NCBI gene (formerly Entrezgene) 238
GeneCards 427
HGNC Symbol HGNC:427
MIM gene 105590
MIM morbid 613014
UniProtKB Gene Name Q9UM73
WikiGene 238
Gene: MAP3K9
Ensembl ID : ENSG00000006432
Description: mitogen-activated protein kinase kinase kinase 9
Gene Synonyms: MEKK9,MLK1,PRKE1
1 APIs:
195 Possible Orthologues:

Expression Atlas ENSG00000006432
NCBI gene (formerly Entrezgene) 4293
GeneCards 6861
HGNC Symbol HGNC:6861
MIM gene 600136
UniProtKB Gene Name P80192
WikiGene 4293