Gene: BCR
Ensembl ID : ENSG00000186716
Description: BCR activator of RhoGEF and GTPase
Gene Synonyms: ALL,BCR1,CML,D22S11,D22S662,PHL
8 APIs:
285 Possible Orthologues:

Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOC GTPase cycle R-HSA-9013106
RAC1 GTPase cycle R-HSA-9013149
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RHOA GTPase cycle R-HSA-8980692
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
FGFR1 mutant receptor activation R-HSA-1839124
RAC2 GTPase cycle R-HSA-9013404
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
RHOB GTPase cycle R-HSA-9013026
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOA GTPase cycle R-HSA-8980692
Signaling by Rho GTPases R-HSA-194315
RHOC GTPase cycle R-HSA-9013106
RHOB GTPase cycle R-HSA-9013026
CDC42 GTPase cycle R-HSA-9013148
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
FGFR1 mutant receptor activation R-HSA-1839124
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR1 in disease R-HSA-5655302
RHO GTPase cycle R-HSA-9012999
RAC2 GTPase cycle R-HSA-9013404
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOB GTPase cycle R-HSA-9013026
RAC2 GTPase cycle R-HSA-9013404
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR in disease R-HSA-1226099
RHOA GTPase cycle R-HSA-8980692
RHOC GTPase cycle R-HSA-9013106
CDC42 GTPase cycle R-HSA-9013148
RAC1 GTPase cycle R-HSA-9013149
Signaling by Rho GTPases R-HSA-194315
RAC3 GTPase cycle R-HSA-9013423
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR1 in disease R-HSA-5655302
RAC3 GTPase cycle R-HSA-9013423
RHOB GTPase cycle R-HSA-9013026
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
CDC42 GTPase cycle R-HSA-9013148
RHOA GTPase cycle R-HSA-8980692
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by FGFR1 in disease R-HSA-5655302
Signal Transduction R-HSA-162582
RAC1 GTPase cycle R-HSA-9013149
RHOC GTPase cycle R-HSA-9013106
RAC2 GTPase cycle R-HSA-9013404
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
RAC2 GTPase cycle R-HSA-9013404
RHOA GTPase cycle R-HSA-8980692
Signal Transduction R-HSA-162582
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
RHOC GTPase cycle R-HSA-9013106
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
RAC1 GTPase cycle R-HSA-9013149
FGFR1 mutant receptor activation R-HSA-1839124
RAC3 GTPase cycle R-HSA-9013423
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by Rho GTPases R-HSA-194315
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
CDC42 GTPase cycle R-HSA-9013148
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOA GTPase cycle R-HSA-8980692
RHOB GTPase cycle R-HSA-9013026
RHOC GTPase cycle R-HSA-9013106
RAC2 GTPase cycle R-HSA-9013404
Disease R-HSA-1643685
RAC1 GTPase cycle R-HSA-9013149
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases R-HSA-194315
RHOA GTPase cycle R-HSA-8980692
RHOC GTPase cycle R-HSA-9013106
Signaling by FGFR1 in disease R-HSA-5655302
RHOB GTPase cycle R-HSA-9013026
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
RAC2 GTPase cycle R-HSA-9013404
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
FGFR1 mutant receptor activation R-HSA-1839124
RHOA GTPase cycle R-HSA-8980692
RHO GTPase cycle R-HSA-9012999
Signal Transduction R-HSA-162582
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC3 GTPase cycle R-HSA-9013423
CDC42 GTPase cycle R-HSA-9013148
RHOC GTPase cycle R-HSA-9013106
Signaling by FGFR in disease R-HSA-1226099
RAC2 GTPase cycle R-HSA-9013404
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
Signaling by Rho GTPases R-HSA-194315
CDC42 GTPase cycle R-HSA-9013148
Disease R-HSA-1643685
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC1 GTPase cycle R-HSA-9013149
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
RHOC GTPase cycle R-HSA-9013106
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR1 in disease R-HSA-5655302
RAC2 GTPase cycle R-HSA-9013404
RHOA GTPase cycle R-HSA-8980692
RAC3 GTPase cycle R-HSA-9013423
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RAC2 GTPase cycle R-HSA-9013404
RHOC GTPase cycle R-HSA-9013106
RHOA GTPase cycle R-HSA-8980692
Signaling by FGFR1 in disease R-HSA-5655302
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
FGFR1 mutant receptor activation R-HSA-1839124
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOB GTPase cycle R-HSA-9013026
RAC1 GTPase cycle R-HSA-9013149
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHO GTPase cycle R-HSA-9012999
RHO GTPase cycle R-HSA-9012999
RHOC GTPase cycle R-HSA-9013106
FGFR1 mutant receptor activation R-HSA-1839124
RAC2 GTPase cycle R-HSA-9013404
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR in disease R-HSA-1226099
Signal Transduction R-HSA-162582
RHOB GTPase cycle R-HSA-9013026
Disease R-HSA-1643685
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOA GTPase cycle R-HSA-8980692

Expression Atlas ENSG00000186716
LRG display in Ensembl gene LRG_1112
NCBI gene (formerly Entrezgene) 613
GeneCards 1014
HGNC Symbol HGNC:1014
MIM gene 151410
MIM morbid 613065
UniProtKB Gene Name P11274
WikiGene 613
Gene: ERBB4
Ensembl ID : ENSG00000178568
Description: erb-b2 receptor tyrosine kinase 4
Gene Synonyms: ALS19,HER4
12 APIs:
320 Possible Orthologues:

Intracellular signaling by second messengers R-HSA-9006925
RAF/MAP kinase cascade R-HSA-5673001
SHC1 events in ERBB2 signaling R-HSA-1250196
Disease R-HSA-1643685
PIP3 activates AKT signaling R-HSA-1257604
Downregulation of ERBB4 signaling R-HSA-1253288
Downregulation of ERBB2 signaling R-HSA-8863795
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by Nuclear Receptors R-HSA-9006931
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by ERBB2 R-HSA-1227986
Estrogen-dependent gene expression R-HSA-9018519
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Neuronal System R-HSA-112316
MAPK family signaling cascades R-HSA-5683057
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by ERBB2 KD Mutants R-HSA-9664565
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Post NMDA receptor activation events R-HSA-438064
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PI3K/AKT Signaling in Cancer R-HSA-2219528
Transmission across Chemical Synapses R-HSA-112315
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
SHC1 events in ERBB4 signaling R-HSA-1250347
PI3K events in ERBB2 signaling R-HSA-1963642
Long-term potentiation R-HSA-9620244
ESR-mediated signaling R-HSA-8939211
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by PTK6 R-HSA-8848021
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative regulation of the PI3K/AKT network R-HSA-199418
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB4 R-HSA-1236394
Signaling by ERBB2 in Cancer R-HSA-1227990
Activation of NMDA receptors and postsynaptic events R-HSA-442755
PI3K/AKT Signaling in Cancer R-HSA-2219528
MAPK family signaling cascades R-HSA-5683057
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by PTK6 R-HSA-8848021
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by Nuclear Receptors R-HSA-9006931
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal Transduction R-HSA-162582
Transmission across Chemical Synapses R-HSA-112315
Downregulation of ERBB2 signaling R-HSA-8863795
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by ERBB2 R-HSA-1227986
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PIP3 activates AKT signaling R-HSA-1257604
ERBB2 Regulates Cell Motility R-HSA-6785631
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by ERBB2 in Cancer R-HSA-1227990
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SHC1 events in ERBB2 signaling R-HSA-1250196
RAF/MAP kinase cascade R-HSA-5673001
ESR-mediated signaling R-HSA-8939211
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Post NMDA receptor activation events R-HSA-438064
Signaling by ERBB4 R-HSA-1236394
Nuclear signaling by ERBB4 R-HSA-1251985
MAPK1/MAPK3 signaling R-HSA-5684996
Long-term potentiation R-HSA-9620244
Intracellular signaling by second messengers R-HSA-9006925
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB2 KD Mutants R-HSA-9664565
Downregulation of ERBB4 signaling R-HSA-1253288
Estrogen-dependent gene expression R-HSA-9018519
PI3K events in ERBB2 signaling R-HSA-1963642
Neuronal System R-HSA-112316
SHC1 events in ERBB4 signaling R-HSA-1250347
Disease R-HSA-1643685
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
MAPK1/MAPK3 signaling R-HSA-5684996
Nuclear signaling by ERBB4 R-HSA-1251985
Intracellular signaling by second messengers R-HSA-9006925
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K events in ERBB2 signaling R-HSA-1963642
Post NMDA receptor activation events R-HSA-438064
RAF/MAP kinase cascade R-HSA-5673001
ERBB2 Regulates Cell Motility R-HSA-6785631
ESR-mediated signaling R-HSA-8939211
MAPK family signaling cascades R-HSA-5683057
Transmission across Chemical Synapses R-HSA-112315
Signaling by ERBB2 in Cancer R-HSA-1227990
Long-term potentiation R-HSA-9620244
PI3K/AKT Signaling in Cancer R-HSA-2219528
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by PTK6 R-HSA-8848021
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Estrogen-dependent gene expression R-HSA-9018519
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by ERBB2 R-HSA-1227986
Downregulation of ERBB4 signaling R-HSA-1253288
PI3K events in ERBB4 signaling R-HSA-1250342
Neuronal System R-HSA-112316
ERBB2 Activates PTK6 Signaling R-HSA-8847993
SHC1 events in ERBB2 signaling R-HSA-1250196
Downregulation of ERBB2 signaling R-HSA-8863795
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative regulation of the PI3K/AKT network R-HSA-199418
Activation of NMDA receptors and postsynaptic events R-HSA-442755
PIP3 activates AKT signaling R-HSA-1257604
Signaling by ERBB4 R-HSA-1236394
Signaling by Nuclear Receptors R-HSA-9006931
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by ERBB2 KD Mutants R-HSA-9664565
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by ERBB2 in Cancer R-HSA-1227990
Downregulation of ERBB2 signaling R-HSA-8863795
SHC1 events in ERBB2 signaling R-HSA-1250196
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Nuclear Receptors R-HSA-9006931
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by ERBB4 R-HSA-1236394
Disease R-HSA-1643685
Transmission across Chemical Synapses R-HSA-112315
ESR-mediated signaling R-HSA-8939211
Nuclear signaling by ERBB4 R-HSA-1251985
Intracellular signaling by second messengers R-HSA-9006925
GRB2 events in ERBB2 signaling R-HSA-1963640
MAPK family signaling cascades R-HSA-5683057
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Downregulation of ERBB4 signaling R-HSA-1253288
Signaling by ERBB2 KD Mutants R-HSA-9664565
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K events in ERBB2 signaling R-HSA-1963642
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by PTK6 R-HSA-8848021
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 R-HSA-1227986
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Estrogen-dependent gene expression R-HSA-9018519
Long-term potentiation R-HSA-9620244
Signal Transduction R-HSA-162582
PI3K events in ERBB4 signaling R-HSA-1250342
MAPK1/MAPK3 signaling R-HSA-5684996
Neuronal System R-HSA-112316
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Post NMDA receptor activation events R-HSA-438064
Activation of NMDA receptors and postsynaptic events R-HSA-442755
PI3K/AKT Signaling in Cancer R-HSA-2219528
PIP3 activates AKT signaling R-HSA-1257604
Neuronal System R-HSA-112316
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by Nuclear Receptors R-HSA-9006931
Intracellular signaling by second messengers R-HSA-9006925
SHC1 events in ERBB2 signaling R-HSA-1250196
Post NMDA receptor activation events R-HSA-438064
Estrogen-dependent gene expression R-HSA-9018519
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K events in ERBB4 signaling R-HSA-1250342
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
MAPK family signaling cascades R-HSA-5683057
Signaling by ERBB4 R-HSA-1236394
Signaling by ERBB2 R-HSA-1227986
PIP3 activates AKT signaling R-HSA-1257604
Signal Transduction R-HSA-162582
Nuclear signaling by ERBB4 R-HSA-1251985
Downregulation of ERBB4 signaling R-HSA-1253288
Signaling by PTK6 R-HSA-8848021
RAF/MAP kinase cascade R-HSA-5673001
PI3K events in ERBB2 signaling R-HSA-1963642
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
GRB2 events in ERBB2 signaling R-HSA-1963640
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 in Cancer R-HSA-1227990
Transmission across Chemical Synapses R-HSA-112315
Long-term potentiation R-HSA-9620244
ESR-mediated signaling R-HSA-8939211
PI3K/AKT Signaling in Cancer R-HSA-2219528
SHC1 events in ERBB4 signaling R-HSA-1250347
ERBB2 Regulates Cell Motility R-HSA-6785631
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
MAPK1/MAPK3 signaling R-HSA-5684996
Downregulation of ERBB2 signaling R-HSA-8863795
SHC1 events in ERBB2 signaling R-HSA-1250196
ERBB2 Regulates Cell Motility R-HSA-6785631
Estrogen-dependent gene expression R-HSA-9018519
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K events in ERBB2 signaling R-HSA-1963642
Long-term potentiation R-HSA-9620244
Neuronal System R-HSA-112316
Signaling by ERBB2 in Cancer R-HSA-1227990
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
Downregulation of ERBB4 signaling R-HSA-1253288
Signaling by Nuclear Receptors R-HSA-9006931
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Negative regulation of the PI3K/AKT network R-HSA-199418
RAF/MAP kinase cascade R-HSA-5673001
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB4 R-HSA-1236394
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
MAPK family signaling cascades R-HSA-5683057
ESR-mediated signaling R-HSA-8939211
MAPK1/MAPK3 signaling R-HSA-5684996
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by ERBB2 R-HSA-1227986
SHC1 events in ERBB4 signaling R-HSA-1250347
PI3K events in ERBB4 signaling R-HSA-1250342
Post NMDA receptor activation events R-HSA-438064
Signal Transduction R-HSA-162582
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by PTK6 R-HSA-8848021
Transmission across Chemical Synapses R-HSA-112315
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PIP3 activates AKT signaling R-HSA-1257604
Long-term potentiation R-HSA-9620244
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Downregulation of ERBB2 signaling R-HSA-8863795
SHC1 events in ERBB2 signaling R-HSA-1250196
Post NMDA receptor activation events R-HSA-438064
MAPK family signaling cascades R-HSA-5683057
Signaling by Nuclear Receptors R-HSA-9006931
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Nuclear signaling by ERBB4 R-HSA-1251985
PI3K events in ERBB4 signaling R-HSA-1250342
Signal Transduction R-HSA-162582
PI3K events in ERBB2 signaling R-HSA-1963642
RAF/MAP kinase cascade R-HSA-5673001
Signaling by ERBB2 in Cancer R-HSA-1227990
PI3K/AKT Signaling in Cancer R-HSA-2219528
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by ERBB4 R-HSA-1236394
Estrogen-dependent gene expression R-HSA-9018519
MAPK1/MAPK3 signaling R-HSA-5684996
Transmission across Chemical Synapses R-HSA-112315
Neuronal System R-HSA-112316
ESR-mediated signaling R-HSA-8939211
Activation of NMDA receptors and postsynaptic events R-HSA-442755
GRB2 events in ERBB2 signaling R-HSA-1963640
Negative regulation of the PI3K/AKT network R-HSA-199418
Intracellular signaling by second messengers R-HSA-9006925
Downregulation of ERBB4 signaling R-HSA-1253288
Signaling by ERBB2 R-HSA-1227986
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by PTK6 R-HSA-8848021
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by PTK6 R-HSA-8848021
Signaling by Nuclear Receptors R-HSA-9006931
ESR-mediated signaling R-HSA-8939211
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by ERBB2 KD Mutants R-HSA-9664565
Post NMDA receptor activation events R-HSA-438064
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K events in ERBB4 signaling R-HSA-1250342
Disease R-HSA-1643685
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Downregulation of ERBB2 signaling R-HSA-8863795
Transmission across Chemical Synapses R-HSA-112315
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
RAF/MAP kinase cascade R-HSA-5673001
MAPK family signaling cascades R-HSA-5683057
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
MAPK1/MAPK3 signaling R-HSA-5684996
Long-term potentiation R-HSA-9620244
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by ERBB2 in Cancer R-HSA-1227990
SHC1 events in ERBB2 signaling R-HSA-1250196
Estrogen-dependent gene expression R-HSA-9018519
Negative regulation of the PI3K/AKT network R-HSA-199418
GRB2 events in ERBB2 signaling R-HSA-1963640
Activation of NMDA receptors and postsynaptic events R-HSA-442755
ERBB2 Regulates Cell Motility R-HSA-6785631
Neuronal System R-HSA-112316
Intracellular signaling by second messengers R-HSA-9006925
Downregulation of ERBB4 signaling R-HSA-1253288
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signal Transduction R-HSA-162582
Signaling by ERBB2 R-HSA-1227986
Signaling by ERBB4 R-HSA-1236394
Long-term potentiation R-HSA-9620244
Signaling by PTK6 R-HSA-8848021
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Estrogen-dependent gene expression R-HSA-9018519
Signaling by Nuclear Receptors R-HSA-9006931
SHC1 events in ERBB2 signaling R-HSA-1250196
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB4 R-HSA-1236394
ESR-mediated signaling R-HSA-8939211
PI3K/AKT Signaling in Cancer R-HSA-2219528
Downregulation of ERBB4 signaling R-HSA-1253288
MAPK1/MAPK3 signaling R-HSA-5684996
Downregulation of ERBB2 signaling R-HSA-8863795
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by ERBB2 KD Mutants R-HSA-9664565
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Transmission across Chemical Synapses R-HSA-112315
Nuclear signaling by ERBB4 R-HSA-1251985
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
MAPK family signaling cascades R-HSA-5683057
SHC1 events in ERBB4 signaling R-HSA-1250347
Post NMDA receptor activation events R-HSA-438064
Neuronal System R-HSA-112316
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal Transduction R-HSA-162582
Signaling by ERBB2 in Cancer R-HSA-1227990
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by ERBB2 R-HSA-1227986
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
PI3K events in ERBB4 signaling R-HSA-1250342
RAF/MAP kinase cascade R-HSA-5673001
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Intracellular signaling by second messengers R-HSA-9006925
Estrogen-dependent gene expression R-HSA-9018519
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by ERBB2 R-HSA-1227986
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Nuclear Receptors R-HSA-9006931
MAPK family signaling cascades R-HSA-5683057
Signaling by ERBB2 in Cancer R-HSA-1227990
Disease R-HSA-1643685
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by PTK6 R-HSA-8848021
Transmission across Chemical Synapses R-HSA-112315
PI3K/AKT Signaling in Cancer R-HSA-2219528
Long-term potentiation R-HSA-9620244
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
ERBB2 Regulates Cell Motility R-HSA-6785631
Downregulation of ERBB2 signaling R-HSA-8863795
GRB2 events in ERBB2 signaling R-HSA-1963640
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Post NMDA receptor activation events R-HSA-438064
SHC1 events in ERBB2 signaling R-HSA-1250196
Nuclear signaling by ERBB4 R-HSA-1251985
ESR-mediated signaling R-HSA-8939211
Signaling by ERBB4 R-HSA-1236394
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Intracellular signaling by second messengers R-HSA-9006925
RAF/MAP kinase cascade R-HSA-5673001
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Neuronal System R-HSA-112316
SHC1 events in ERBB4 signaling R-HSA-1250347
MAPK1/MAPK3 signaling R-HSA-5684996
Downregulation of ERBB4 signaling R-HSA-1253288

Expression Atlas ENSG00000178568
NCBI gene (formerly Entrezgene) 2066
GeneCards 3432
HGNC Symbol HGNC:3432
MIM gene 600543
MIM morbid 615515
UniProtKB Gene Name Q15303
WikiGene 2066
Gene: TEK
Ensembl ID : ENSG00000120156
Description: TEK receptor tyrosine kinase
Gene Synonyms: CD202B,TIE-2,TIE2,VMCM,VMCM1
8 APIs:
166 Possible Orthologues:

Signal Transduction R-HSA-162582
Cell surface interactions at the vascular wall R-HSA-202733
Tie2 Signaling R-HSA-210993
Hemostasis R-HSA-109582
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Cell surface interactions at the vascular wall R-HSA-202733
MAPK1/MAPK3 signaling R-HSA-5684996
Tie2 Signaling R-HSA-210993
MAPK family signaling cascades R-HSA-5683057
Hemostasis R-HSA-109582
Signal Transduction R-HSA-162582
Tie2 Signaling R-HSA-210993
MAPK family signaling cascades R-HSA-5683057
Hemostasis R-HSA-109582
RAF/MAP kinase cascade R-HSA-5673001
Cell surface interactions at the vascular wall R-HSA-202733
MAPK1/MAPK3 signaling R-HSA-5684996
Cell surface interactions at the vascular wall R-HSA-202733
Tie2 Signaling R-HSA-210993
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
Hemostasis R-HSA-109582
RAF/MAP kinase cascade R-HSA-5673001
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
MAPK1/MAPK3 signaling R-HSA-5684996
Cell surface interactions at the vascular wall R-HSA-202733
Hemostasis R-HSA-109582
Tie2 Signaling R-HSA-210993
Cell surface interactions at the vascular wall R-HSA-202733
Hemostasis R-HSA-109582
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
MAPK1/MAPK3 signaling R-HSA-5684996
Tie2 Signaling R-HSA-210993
Tie2 Signaling R-HSA-210993
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
Cell surface interactions at the vascular wall R-HSA-202733
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Hemostasis R-HSA-109582
RAF/MAP kinase cascade R-HSA-5673001
Hemostasis R-HSA-109582
Tie2 Signaling R-HSA-210993
Cell surface interactions at the vascular wall R-HSA-202733
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
RAF/MAP kinase cascade R-HSA-5673001
Tie2 Signaling R-HSA-210993
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
Cell surface interactions at the vascular wall R-HSA-202733
Signal Transduction R-HSA-162582
Hemostasis R-HSA-109582
Hemostasis R-HSA-109582
RAF/MAP kinase cascade R-HSA-5673001
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Tie2 Signaling R-HSA-210993
Cell surface interactions at the vascular wall R-HSA-202733

Expression Atlas ENSG00000120156
NCBI gene (formerly Entrezgene) 7010
GeneCards 11724
HGNC Symbol HGNC:11724
MIM gene 600221
MIM morbid 617272
UniProtKB Gene Name Q02763
WikiGene 7010
Gene: ITK
Ensembl ID : ENSG00000113263
Description: IL2 inducible T cell kinase
Gene Synonyms: EMT,LYK,PSCTK2
1 APIs:
208 Possible Orthologues:

Adaptive Immune System R-HSA-1280218
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Adaptive Immune System R-HSA-1280218
TCR signaling R-HSA-202403
FCERI mediated Ca+2 mobilization R-HSA-2871809
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Generation of second messenger molecules R-HSA-202433
TCR signaling R-HSA-202403
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Generation of second messenger molecules R-HSA-202433
Adaptive Immune System R-HSA-1280218
FCERI mediated Ca+2 mobilization R-HSA-2871809
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
FCERI mediated Ca+2 mobilization R-HSA-2871809
TCR signaling R-HSA-202403
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Adaptive Immune System R-HSA-1280218
Generation of second messenger molecules R-HSA-202433
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
TCR signaling R-HSA-202403
Adaptive Immune System R-HSA-1280218
FCERI mediated Ca+2 mobilization R-HSA-2871809
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Generation of second messenger molecules R-HSA-202433
Generation of second messenger molecules R-HSA-202433
FCERI mediated Ca+2 mobilization R-HSA-2871809
Immune System R-HSA-168256
TCR signaling R-HSA-202403
Adaptive Immune System R-HSA-1280218
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Innate Immune System R-HSA-168249
Adaptive Immune System R-HSA-1280218
Generation of second messenger molecules R-HSA-202433
TCR signaling R-HSA-202403
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
FCERI mediated Ca+2 mobilization R-HSA-2871809
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Adaptive Immune System R-HSA-1280218
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Generation of second messenger molecules R-HSA-202433
TCR signaling R-HSA-202403
FCERI mediated Ca+2 mobilization R-HSA-2871809
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
FCERI mediated Ca+2 mobilization R-HSA-2871809
TCR signaling R-HSA-202403
Innate Immune System R-HSA-168249
Generation of second messenger molecules R-HSA-202433
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Innate Immune System R-HSA-168249
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
TCR signaling R-HSA-202403
Adaptive Immune System R-HSA-1280218
FCERI mediated Ca+2 mobilization R-HSA-2871809
Immune System R-HSA-168256
Generation of second messenger molecules R-HSA-202433
Generation of second messenger molecules R-HSA-202433
FCERI mediated Ca+2 mobilization R-HSA-2871809
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
TCR signaling R-HSA-202403

Expression Atlas ENSG00000113263
LRG display in Ensembl gene LRG_189
NCBI gene (formerly Entrezgene) 3702
GeneCards 6171
HGNC Symbol HGNC:6171
MIM gene 186973
MIM morbid 613011
UniProtKB Gene Name Q08881
WikiGene 3702
Gene: RAF1
Ensembl ID : ENSG00000132155
Description: Raf-1 proto-oncogene, serine/threonine kinase
Gene Synonyms: C-RAF,CRAF,RAF-1
7 APIs:
224 Possible Orthologues:

Signaling downstream of RAS mutants R-HSA-9649948
CD209 (DC-SIGN) signaling R-HSA-5621575
RAF activation R-HSA-5673000
Signaling by RAS mutants R-HSA-6802949
Signaling by RAF1 mutants R-HSA-9656223
Platelet activation, signaling and aggregation R-HSA-76002
Oncogenic MAPK signaling R-HSA-6802957
Transport of small molecules R-HSA-382551
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Innate Immune System R-HSA-168249
MAPK family signaling cascades R-HSA-5683057
Disease R-HSA-1643685
MAPK1/MAPK3 signaling R-HSA-5684996
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Stimuli-sensing channels R-HSA-2672351
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF/MAP kinase cascade R-HSA-5673001
Negative feedback regulation of MAPK pathway R-HSA-5674499
Adaptive Immune System R-HSA-1280218
GP1b-IX-V activation signalling R-HSA-430116
Immune System R-HSA-168256
Ion channel transport R-HSA-983712
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
C-type lectin receptors (CLRs) R-HSA-5621481
Negative regulation of MAPK pathway R-HSA-5675221
Signal Transduction R-HSA-162582
MAP2K and MAPK activation R-HSA-5674135
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Hemostasis R-HSA-109582
Rap1 signalling R-HSA-392517
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Hemostasis R-HSA-109582
Negative feedback regulation of MAPK pathway R-HSA-5674499
CD209 (DC-SIGN) signaling R-HSA-5621575
MAP2K and MAPK activation R-HSA-5674135
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Negative regulation of MAPK pathway R-HSA-5675221
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Platelet activation, signaling and aggregation R-HSA-76002
Rap1 signalling R-HSA-392517
Signaling by RAF1 mutants R-HSA-9656223
Signaling by RAS mutants R-HSA-6802949
MAPK family signaling cascades R-HSA-5683057
Adaptive Immune System R-HSA-1280218
Signal Transduction R-HSA-162582
GP1b-IX-V activation signalling R-HSA-430116
Innate Immune System R-HSA-168249
Ion channel transport R-HSA-983712
Immune System R-HSA-168256
C-type lectin receptors (CLRs) R-HSA-5621481
Stimuli-sensing channels R-HSA-2672351
MAPK1/MAPK3 signaling R-HSA-5684996
Disease R-HSA-1643685
RAF/MAP kinase cascade R-HSA-5673001
Signaling by MRAS-complex mutants R-HSA-9660537
Transport of small molecules R-HSA-382551
Oncogenic MAPK signaling R-HSA-6802957
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF activation R-HSA-5673000
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling downstream of RAS mutants R-HSA-9649948
GP1b-IX-V activation signalling R-HSA-430116
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by RAF1 mutants R-HSA-9656223
Immune System R-HSA-168256
Transport of small molecules R-HSA-382551
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Oncogenic MAPK signaling R-HSA-6802957
RAF activation R-HSA-5673000
MAPK family signaling cascades R-HSA-5683057
C-type lectin receptors (CLRs) R-HSA-5621481
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Ion channel transport R-HSA-983712
Platelet activation, signaling and aggregation R-HSA-76002
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by MRAS-complex mutants R-HSA-9660537
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling downstream of RAS mutants R-HSA-9649948
Stimuli-sensing channels R-HSA-2672351
Rap1 signalling R-HSA-392517
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Adaptive Immune System R-HSA-1280218
Signal Transduction R-HSA-162582
Innate Immune System R-HSA-168249
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Disease R-HSA-1643685
RAF/MAP kinase cascade R-HSA-5673001
MAP2K and MAPK activation R-HSA-5674135
Signaling by RAS mutants R-HSA-6802949
Hemostasis R-HSA-109582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative regulation of MAPK pathway R-HSA-5675221
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAPK family signaling cascades R-HSA-5683057
Signaling by RAS mutants R-HSA-6802949
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
GP1b-IX-V activation signalling R-HSA-430116
Oncogenic MAPK signaling R-HSA-6802957
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Platelet activation, signaling and aggregation R-HSA-76002
Adaptive Immune System R-HSA-1280218
Hemostasis R-HSA-109582
Rap1 signalling R-HSA-392517
MAP2K and MAPK activation R-HSA-5674135
Transport of small molecules R-HSA-382551
Signaling downstream of RAS mutants R-HSA-9649948
Stimuli-sensing channels R-HSA-2672351
C-type lectin receptors (CLRs) R-HSA-5621481
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAPK1/MAPK3 signaling R-HSA-5684996
CD209 (DC-SIGN) signaling R-HSA-5621575
RAF/MAP kinase cascade R-HSA-5673001
Signaling by MRAS-complex mutants R-HSA-9660537
Ion channel transport R-HSA-983712
Signaling by RAF1 mutants R-HSA-9656223
Disease R-HSA-1643685
MAPK1/MAPK3 signaling R-HSA-5684996
RAF activation R-HSA-5673000
MAP2K and MAPK activation R-HSA-5674135
Rap1 signalling R-HSA-392517
CD209 (DC-SIGN) signaling R-HSA-5621575
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Hemostasis R-HSA-109582
Ion channel transport R-HSA-983712
Negative regulation of MAPK pathway R-HSA-5675221
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Transport of small molecules R-HSA-382551
Stimuli-sensing channels R-HSA-2672351
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Platelet activation, signaling and aggregation R-HSA-76002
RAF/MAP kinase cascade R-HSA-5673001
Oncogenic MAPK signaling R-HSA-6802957
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by MRAS-complex mutants R-HSA-9660537
Adaptive Immune System R-HSA-1280218
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Innate Immune System R-HSA-168249
Signal Transduction R-HSA-162582
GP1b-IX-V activation signalling R-HSA-430116
Immune System R-HSA-168256
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by RAF1 mutants R-HSA-9656223
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Disease R-HSA-1643685
Signaling by RAS mutants R-HSA-6802949
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by MRAS-complex mutants R-HSA-9660537
Oncogenic MAPK signaling R-HSA-6802957
RAF activation R-HSA-5673000
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
Ion channel transport R-HSA-983712
GP1b-IX-V activation signalling R-HSA-430116
Negative regulation of MAPK pathway R-HSA-5675221
Platelet activation, signaling and aggregation R-HSA-76002
Stimuli-sensing channels R-HSA-2672351
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Rap1 signalling R-HSA-392517
Transport of small molecules R-HSA-382551
Signaling by RAS mutants R-HSA-6802949
Signaling downstream of RAS mutants R-HSA-9649948
MAPK family signaling cascades R-HSA-5683057
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
C-type lectin receptors (CLRs) R-HSA-5621481
Immune System R-HSA-168256
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Adaptive Immune System R-HSA-1280218
CD209 (DC-SIGN) signaling R-HSA-5621575
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by RAF1 mutants R-HSA-9656223
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Hemostasis R-HSA-109582
Innate Immune System R-HSA-168249
Signaling by MRAS-complex mutants R-HSA-9660537
Signal Transduction R-HSA-162582
Negative feedback regulation of MAPK pathway R-HSA-5674499
Negative regulation of MAPK pathway R-HSA-5675221
GP1b-IX-V activation signalling R-HSA-430116
Immune System R-HSA-168256
RAF activation R-HSA-5673000
Adaptive Immune System R-HSA-1280218
MAPK1/MAPK3 signaling R-HSA-5684996
Disease R-HSA-1643685
Transport of small molecules R-HSA-382551
Stimuli-sensing channels R-HSA-2672351
CD209 (DC-SIGN) signaling R-HSA-5621575
Oncogenic MAPK signaling R-HSA-6802957
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Innate Immune System R-HSA-168249
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
Ion channel transport R-HSA-983712
MAP2K and MAPK activation R-HSA-5674135
Hemostasis R-HSA-109582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAS mutants R-HSA-6802949
C-type lectin receptors (CLRs) R-HSA-5621481
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by RAF1 mutants R-HSA-9656223
Rap1 signalling R-HSA-392517
Signaling downstream of RAS mutants R-HSA-9649948
Transport of small molecules R-HSA-382551
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by RAF1 mutants R-HSA-9656223
Immune System R-HSA-168256
Signaling downstream of RAS mutants R-HSA-9649948
Negative feedback regulation of MAPK pathway R-HSA-5674499
Platelet activation, signaling and aggregation R-HSA-76002
MAPK1/MAPK3 signaling R-HSA-5684996
Oncogenic MAPK signaling R-HSA-6802957
Signaling by MRAS-complex mutants R-HSA-9660537
RAF/MAP kinase cascade R-HSA-5673001
Innate Immune System R-HSA-168249
Signaling by BRAF and RAF1 fusions R-HSA-6802952
GP1b-IX-V activation signalling R-HSA-430116
Signal Transduction R-HSA-162582
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Hemostasis R-HSA-109582
MAPK family signaling cascades R-HSA-5683057
Ion channel transport R-HSA-983712
Stimuli-sensing channels R-HSA-2672351
Disease R-HSA-1643685
Signaling by RAS mutants R-HSA-6802949
Rap1 signalling R-HSA-392517
Negative regulation of MAPK pathway R-HSA-5675221
RAF activation R-HSA-5673000
CD209 (DC-SIGN) signaling R-HSA-5621575
C-type lectin receptors (CLRs) R-HSA-5621481
Adaptive Immune System R-HSA-1280218
MAP2K and MAPK activation R-HSA-5674135
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
Innate Immune System R-HSA-168249
Signaling by RAF1 mutants R-HSA-9656223
MAPK family signaling cascades R-HSA-5683057
Transport of small molecules R-HSA-382551
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
Adaptive Immune System R-HSA-1280218
C-type lectin receptors (CLRs) R-HSA-5621481
Rap1 signalling R-HSA-392517
Platelet activation, signaling and aggregation R-HSA-76002
Hemostasis R-HSA-109582
Signaling by MRAS-complex mutants R-HSA-9660537
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Ion channel transport R-HSA-983712
Signaling by RAS mutants R-HSA-6802949
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
GP1b-IX-V activation signalling R-HSA-430116
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Stimuli-sensing channels R-HSA-2672351
Signaling downstream of RAS mutants R-HSA-9649948
CD209 (DC-SIGN) signaling R-HSA-5621575
RAF activation R-HSA-5673000
Negative feedback regulation of MAPK pathway R-HSA-5674499
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
MAPK1/MAPK3 signaling R-HSA-5684996
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
MAP2K and MAPK activation R-HSA-5674135
Signaling by BRAF and RAF1 fusions R-HSA-6802952
C-type lectin receptors (CLRs) R-HSA-5621481
Adaptive Immune System R-HSA-1280218
Signaling by RAF1 mutants R-HSA-9656223
Oncogenic MAPK signaling R-HSA-6802957
Rap1 signalling R-HSA-392517
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by RAS mutants R-HSA-6802949
MAPK1/MAPK3 signaling R-HSA-5684996
Platelet activation, signaling and aggregation R-HSA-76002
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
Stimuli-sensing channels R-HSA-2672351
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Ion channel transport R-HSA-983712
Signaling downstream of RAS mutants R-HSA-9649948
MAPK family signaling cascades R-HSA-5683057
Negative regulation of MAPK pathway R-HSA-5675221
Transport of small molecules R-HSA-382551
Immune System R-HSA-168256
GP1b-IX-V activation signalling R-HSA-430116
RAF/MAP kinase cascade R-HSA-5673001
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
MAP2K and MAPK activation R-HSA-5674135
Signaling by MRAS-complex mutants R-HSA-9660537
Hemostasis R-HSA-109582
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative feedback regulation of MAPK pathway R-HSA-5674499
RAF activation R-HSA-5673000

Expression Atlas ENSG00000132155
LRG display in Ensembl gene LRG_413
NCBI gene (formerly Entrezgene) 5894
GeneCards 9829
HGNC Symbol HGNC:9829
MIM gene 164760
MIM morbid 615916
UniProtKB Gene Name P04049
WikiGene 5894
Gene: TGFBR1
Ensembl ID : ENSG00000106799
Description: transforming growth factor beta receptor 1
Gene Synonyms: ACVRLK4,ALK-5,ALK5,ESS1,MSSE,TBR-I,TBRI
2 APIs:
236 Possible Orthologues:

Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Signaling by TGFB family members R-HSA-9006936
Post-translational protein modification R-HSA-597592
TGFBR1 KD Mutants in Cancer R-HSA-3656532
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
UCH proteinases R-HSA-5689603
Signal Transduction R-HSA-162582
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Ub-specific processing proteases R-HSA-5689880
Metabolism of proteins R-HSA-392499
Deubiquitination R-HSA-5688426
Disease R-HSA-1643685
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signaling by TGFB family members R-HSA-9006936
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Ub-specific processing proteases R-HSA-5689880
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Disease R-HSA-1643685
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Deubiquitination R-HSA-5688426
Metabolism of proteins R-HSA-392499
UCH proteinases R-HSA-5689603
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Post-translational protein modification R-HSA-597592
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Disease R-HSA-1643685
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signal Transduction R-HSA-162582
Ub-specific processing proteases R-HSA-5689880
Deubiquitination R-HSA-5688426
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Metabolism of proteins R-HSA-392499
TGFBR1 KD Mutants in Cancer R-HSA-3656532
TGF-beta receptor signaling activates SMADs R-HSA-2173789
UCH proteinases R-HSA-5689603
Post-translational protein modification R-HSA-597592
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Signaling by TGFB family members R-HSA-9006936
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Deubiquitination R-HSA-5688426
Ub-specific processing proteases R-HSA-5689880
Disease R-HSA-1643685
Signaling by TGFB family members R-HSA-9006936
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Signal Transduction R-HSA-162582
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Metabolism of proteins R-HSA-392499
UCH proteinases R-HSA-5689603
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Post-translational protein modification R-HSA-597592
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Downregulation of TGF-beta receptor signaling R-HSA-2173788
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Deubiquitination R-HSA-5688426
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
UCH proteinases R-HSA-5689603
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Ub-specific processing proteases R-HSA-5689880
Signaling by TGFB family members R-HSA-9006936
Post-translational protein modification R-HSA-597592
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TGF-beta receptor signaling activates SMADs R-HSA-2173789
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Metabolism of proteins R-HSA-392499
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Signal Transduction R-HSA-162582
Deubiquitination R-HSA-5688426
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Ub-specific processing proteases R-HSA-5689880
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signaling by TGFB family members R-HSA-9006936
Signaling by TGF-beta Receptor Complex R-HSA-170834
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Metabolism of proteins R-HSA-392499
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
UCH proteinases R-HSA-5689603
Post-translational protein modification R-HSA-597592
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Disease R-HSA-1643685
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Metabolism of proteins R-HSA-392499
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Ub-specific processing proteases R-HSA-5689880
Signaling by TGFB family members R-HSA-9006936
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Post-translational protein modification R-HSA-597592
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Deubiquitination R-HSA-5688426
UCH proteinases R-HSA-5689603
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Disease R-HSA-1643685
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Deubiquitination R-HSA-5688426
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
UCH proteinases R-HSA-5689603
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Signal Transduction R-HSA-162582
Ub-specific processing proteases R-HSA-5689880
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Metabolism of proteins R-HSA-392499
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Post-translational protein modification R-HSA-597592
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Deubiquitination R-HSA-5688426
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR1 KD Mutants in Cancer R-HSA-3656532
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Metabolism of proteins R-HSA-392499
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
UCH proteinases R-HSA-5689603
Signaling by TGFB family members R-HSA-9006936
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Ub-specific processing proteases R-HSA-5689880
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Post-translational protein modification R-HSA-597592
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Signal Transduction R-HSA-162582
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Metabolism of proteins R-HSA-392499
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGFB family members R-HSA-9006936
Disease R-HSA-1643685
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Deubiquitination R-HSA-5688426
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Post-translational protein modification R-HSA-597592
Signal Transduction R-HSA-162582
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
UCH proteinases R-HSA-5689603
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Ub-specific processing proteases R-HSA-5689880
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790

Expression Atlas ENSG00000106799
NCBI gene (formerly Entrezgene) 7046
GeneCards 11772
HGNC Symbol HGNC:11772
MIM gene 190181
MIM morbid 609192
UniProtKB Gene Name Q5T7S2
WikiGene 7046
Gene: ACVR2B
Ensembl ID : ENSG00000114739
Description: activin A receptor type 2B
Gene Synonyms: ACTR-IIB
1 APIs:
259 Possible Orthologues:

Signaling by Activin R-HSA-1502540
Signaling by TGFB family members R-HSA-9006936
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Signaling by NODAL R-HSA-1181150
Regulation of signaling by NODAL R-HSA-1433617
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by Activin R-HSA-1502540
Developmental Biology R-HSA-1266738
Regulation of signaling by NODAL R-HSA-1433617
Signaling by BMP R-HSA-201451
Signaling by NODAL R-HSA-1181150
Signaling by Activin R-HSA-1502540
Regulation of signaling by NODAL R-HSA-1433617
Signaling by NODAL R-HSA-1181150
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by Activin R-HSA-1502540
Signal Transduction R-HSA-162582
Signaling by NODAL R-HSA-1181150
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Regulation of signaling by NODAL R-HSA-1433617
Signaling by TGFB family members R-HSA-9006936
Signaling by Activin R-HSA-1502540
Signaling by NODAL R-HSA-1181150
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Regulation of signaling by NODAL R-HSA-1433617
Regulation of signaling by NODAL R-HSA-1433617
Signaling by TGFB family members R-HSA-9006936
Signaling by NODAL R-HSA-1181150
Signaling by Activin R-HSA-1502540
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Regulation of signaling by NODAL R-HSA-1433617
Signaling by TGFB family members R-HSA-9006936
Signaling by NODAL R-HSA-1181150
Signaling by Activin R-HSA-1502540
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Regulation of signaling by NODAL R-HSA-1433617
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by Activin R-HSA-1502540
Signaling by NODAL R-HSA-1181150
Signaling by Activin R-HSA-1502540
Signaling by NODAL R-HSA-1181150
Signaling by TGFB family members R-HSA-9006936
Regulation of signaling by NODAL R-HSA-1433617
Signaling by BMP R-HSA-201451
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by NODAL R-HSA-1181150
Developmental Biology R-HSA-1266738
Signaling by TGFB family members R-HSA-9006936
Regulation of signaling by NODAL R-HSA-1433617
Signaling by Activin R-HSA-1502540
Signal Transduction R-HSA-162582

Expression Atlas ENSG00000114739
NCBI gene (formerly Entrezgene) 93
GeneCards 174
HGNC Symbol HGNC:174
MIM gene 602730
MIM morbid 613751
UniProtKB Gene Name Q13705
WikiGene 93
Gene: IRAK4
Ensembl ID : ENSG00000198001
Description: interleukin 1 receptor associated kinase 4
Gene Synonyms: NY-REN-64
1 APIs:
202 Possible Orthologues:

PIP3 activates AKT signaling R-HSA-1257604
MyD88 dependent cascade initiated on endosome R-HSA-975155
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll-like Receptor Cascades R-HSA-168898
Diseases associated with the TLR signaling cascade R-HSA-5602358
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Diseases of Immune System R-HSA-5260271
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Interleukin-1 signaling R-HSA-9020702
Immune System R-HSA-168256
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Disease R-HSA-1643685
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Intracellular signaling by second messengers R-HSA-9006925
Cytokine Signaling in Immune system R-HSA-1280215
IRAK4 deficiency (TLR5) R-HSA-5603037
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Interleukins R-HSA-449147
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signal Transduction R-HSA-162582
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Innate Immune System R-HSA-168249
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Interleukin-1 family signaling R-HSA-446652
Cytokine Signaling in Immune system R-HSA-1280215
MyD88 dependent cascade initiated on endosome R-HSA-975155
Diseases of Immune System R-HSA-5260271
MyD88 cascade initiated on plasma membrane R-HSA-975871
Diseases associated with the TLR signaling cascade R-HSA-5602358
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Intracellular signaling by second messengers R-HSA-9006925
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Immune System R-HSA-168256
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
PIP3 activates AKT signaling R-HSA-1257604
Innate Immune System R-HSA-168249
Negative regulation of the PI3K/AKT network R-HSA-199418
Disease R-HSA-1643685
IRAK4 deficiency (TLR5) R-HSA-5603037
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signal Transduction R-HSA-162582
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Interleukin-1 signaling R-HSA-9020702
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Signaling by Interleukins R-HSA-449147
PIP3 activates AKT signaling R-HSA-1257604
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88 dependent cascade initiated on endosome R-HSA-975155
Diseases associated with the TLR signaling cascade R-HSA-5602358
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Disease R-HSA-1643685
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Intracellular signaling by second messengers R-HSA-9006925
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll-like Receptor Cascades R-HSA-168898
Innate Immune System R-HSA-168249
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Interleukin-1 signaling R-HSA-9020702
Diseases of Immune System R-HSA-5260271
Negative regulation of the PI3K/AKT network R-HSA-199418
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
IRAK4 deficiency (TLR5) R-HSA-5603037
Interleukin-1 family signaling R-HSA-446652
IRAK4 deficiency (TLR5) R-HSA-5603037
Diseases associated with the TLR signaling cascade R-HSA-5602358
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Cytokine Signaling in Immune system R-HSA-1280215
Toll-like Receptor Cascades R-HSA-168898
Disease R-HSA-1643685
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Interleukin-1 signaling R-HSA-9020702
PIP3 activates AKT signaling R-HSA-1257604
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Immune System R-HSA-168256
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Innate Immune System R-HSA-168249
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
Diseases of Immune System R-HSA-5260271
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
MyD88 cascade initiated on plasma membrane R-HSA-975871
Negative regulation of the PI3K/AKT network R-HSA-199418
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Diseases of Immune System R-HSA-5260271
Diseases associated with the TLR signaling cascade R-HSA-5602358
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-1 signaling R-HSA-9020702
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88 dependent cascade initiated on endosome R-HSA-975155
Innate Immune System R-HSA-168249
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
MyD88 cascade initiated on plasma membrane R-HSA-975871
Negative regulation of the PI3K/AKT network R-HSA-199418
Disease R-HSA-1643685
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Interleukin-1 family signaling R-HSA-446652
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IRAK4 deficiency (TLR5) R-HSA-5603037
PIP3 activates AKT signaling R-HSA-1257604
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Intracellular signaling by second messengers R-HSA-9006925
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by Interleukins R-HSA-449147
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Innate Immune System R-HSA-168249
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signal Transduction R-HSA-162582
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Disease R-HSA-1643685
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
PIP3 activates AKT signaling R-HSA-1257604
Immune System R-HSA-168256
MyD88 cascade initiated on plasma membrane R-HSA-975871
Diseases associated with the TLR signaling cascade R-HSA-5602358
Signaling by Interleukins R-HSA-449147
Intracellular signaling by second messengers R-HSA-9006925
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Interleukin-1 signaling R-HSA-9020702
Diseases of Immune System R-HSA-5260271
IRAK4 deficiency (TLR5) R-HSA-5603037
Interleukin-1 family signaling R-HSA-446652
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Negative regulation of the PI3K/AKT network R-HSA-199418
Toll-like Receptor Cascades R-HSA-168898
IRAK4 deficiency (TLR5) R-HSA-5603037
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal Transduction R-HSA-162582
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Immune System R-HSA-168256
Cytokine Signaling in Immune system R-HSA-1280215
MyD88 cascade initiated on plasma membrane R-HSA-975871
Disease R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Diseases associated with the TLR signaling cascade R-HSA-5602358
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Innate Immune System R-HSA-168249
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
Toll-like Receptor Cascades R-HSA-168898
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Diseases of Immune System R-HSA-5260271
Interleukin-1 signaling R-HSA-9020702
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Disease R-HSA-1643685
Innate Immune System R-HSA-168249
IRAK4 deficiency (TLR5) R-HSA-5603037
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Interleukin-1 family signaling R-HSA-446652
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Signal Transduction R-HSA-162582
PIP3 activates AKT signaling R-HSA-1257604
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Intracellular signaling by second messengers R-HSA-9006925
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Interleukin-1 signaling R-HSA-9020702
MyD88 dependent cascade initiated on endosome R-HSA-975155
Signaling by Interleukins R-HSA-449147
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Toll-like Receptor Cascades R-HSA-168898
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of Immune System R-HSA-5260271
Diseases associated with the TLR signaling cascade R-HSA-5602358
Negative regulation of the PI3K/AKT network R-HSA-199418
Immune System R-HSA-168256
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Disease R-HSA-1643685
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Immune System R-HSA-168256
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Diseases associated with the TLR signaling cascade R-HSA-5602358
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
PIP3 activates AKT signaling R-HSA-1257604
IRAK4 deficiency (TLR5) R-HSA-5603037
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Negative regulation of the PI3K/AKT network R-HSA-199418
Toll-like Receptor Cascades R-HSA-168898
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
Interleukin-1 signaling R-HSA-9020702
Diseases of Immune System R-HSA-5260271
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Innate Immune System R-HSA-168249
Signaling by Interleukins R-HSA-449147
Toll-like Receptor Cascades R-HSA-168898
Interleukin-1 signaling R-HSA-9020702
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Immune System R-HSA-168256
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
IRAK4 deficiency (TLR2/4) R-HSA-5603041
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Intracellular signaling by second messengers R-HSA-9006925
PIP3 activates AKT signaling R-HSA-1257604
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Negative regulation of the PI3K/AKT network R-HSA-199418
IRAK4 deficiency (TLR5) R-HSA-5603037
MyD88 dependent cascade initiated on endosome R-HSA-975155
Diseases of Immune System R-HSA-5260271
Signal Transduction R-HSA-162582
Innate Immune System R-HSA-168249
MyD88 cascade initiated on plasma membrane R-HSA-975871
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Diseases associated with the TLR signaling cascade R-HSA-5602358
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Disease R-HSA-1643685
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110

Expression Atlas ENSG00000198001
LRG display in Ensembl gene LRG_75
NCBI gene (formerly Entrezgene) 51135
GeneCards 17967
HGNC Symbol HGNC:17967
MIM gene 606883
MIM morbid 607676
UniProtKB Gene Name Q9NWZ3
WikiGene 51135