Ensembl ID : ENSG00000197891
Description: solute carrier family 22 member 12
Gene Synonyms: OAT4L,RST,URAT1
7 APIs:
475 Possible Orthologues:

Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) R-HSA-5619071
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551
Organic anion transport R-HSA-561048
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Disorders of transmembrane transporters R-HSA-5619115
SLC transporter disorders R-HSA-5619102
Disease R-HSA-1643685
Transport of small molecules R-HSA-382551
Organic cation/anion/zwitterion transport R-HSA-549132
SLC transporter disorders R-HSA-5619102
Organic anion transport R-HSA-561048
Disorders of transmembrane transporters R-HSA-5619115
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) R-HSA-5619071
Disease R-HSA-1643685
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Disorders of transmembrane transporters R-HSA-5619115
SLC-mediated transmembrane transport R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) R-HSA-5619071
Organic anion transport R-HSA-561048
Disease R-HSA-1643685
Transport of small molecules R-HSA-382551
SLC transporter disorders R-HSA-5619102
Organic anion transport R-HSA-561048
SLC transporter disorders R-HSA-5619102
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic cation/anion/zwitterion transport R-HSA-549132
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) R-HSA-5619071
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
Disorders of transmembrane transporters R-HSA-5619115
Disease R-HSA-1643685
Disorders of transmembrane transporters R-HSA-5619115
SLC transporter disorders R-HSA-5619102
Disease R-HSA-1643685
Organic anion transport R-HSA-561048
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) R-HSA-5619071
Transport of small molecules R-HSA-382551
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Disorders of transmembrane transporters R-HSA-5619115
Transport of small molecules R-HSA-382551
Disease R-HSA-1643685
Organic anion transport R-HSA-561048
SLC-mediated transmembrane transport R-HSA-425407
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) R-HSA-5619071
SLC transporter disorders R-HSA-5619102

Expression Atlas ENSG00000197891
NCBI gene (formerly Entrezgene) 116085
GeneCards 17989
HGNC Symbol HGNC:17989
MIM gene 607096
MIM morbid 220150
UniProtKB Gene Name Q96S37
WikiGene 116085
Gene: SLC22A6
Ensembl ID : ENSG00000197901
Description: solute carrier family 22 member 6
Gene Synonyms: OAT1,PAHT,ROAT1
2 APIs:
495 Possible Orthologues:

Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic cation/anion/zwitterion transport R-HSA-549132
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Organic anion transport R-HSA-561048
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
Organic cation/anion/zwitterion transport R-HSA-549132
Organic anion transport R-HSA-561048
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048
Transport of small molecules R-HSA-382551
Organic cation/anion/zwitterion transport R-HSA-549132

Expression Atlas ENSG00000197901
NCBI gene (formerly Entrezgene) 9356
GeneCards 10970
HGNC Symbol HGNC:10970
MIM gene 607582
UniProtKB Gene Name Q4U2R8
WikiGene 9356
Gene: SLC22A8
Ensembl ID : ENSG00000149452
Description: solute carrier family 22 member 8
Gene Synonyms: OAT3
2 APIs:
304 Possible Orthologues:

Organic cation/anion/zwitterion transport R-HSA-549132
Organic anion transport R-HSA-561048
Transport of small molecules R-HSA-382551
Ciprofloxacin ADME R-HSA-9793528
SLC-mediated transmembrane transport R-HSA-425407
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Drug ADME R-HSA-9748784
Ciprofloxacin ADME R-HSA-9793528
Organic anion transport R-HSA-561048
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Drug ADME R-HSA-9748784
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
Drug ADME R-HSA-9748784
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048
Ciprofloxacin ADME R-HSA-9793528
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic cation/anion/zwitterion transport R-HSA-549132
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551
Organic anion transport R-HSA-561048
Ciprofloxacin ADME R-HSA-9793528
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Drug ADME R-HSA-9748784
Ciprofloxacin ADME R-HSA-9793528
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
Drug ADME R-HSA-9748784
Organic cation/anion/zwitterion transport R-HSA-549132
Ciprofloxacin ADME R-HSA-9793528
Drug ADME R-HSA-9748784
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
Organic anion transport R-HSA-561048
Organic cation/anion/zwitterion transport R-HSA-549132
SLC-mediated transmembrane transport R-HSA-425407
Ciprofloxacin ADME R-HSA-9793528
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Drug ADME R-HSA-9748784
Transport of small molecules R-HSA-382551
Organic cation/anion/zwitterion transport R-HSA-549132
Organic anion transport R-HSA-561048
Transport of small molecules R-HSA-382551
Drug ADME R-HSA-9748784
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Ciprofloxacin ADME R-HSA-9793528
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048
SLC-mediated transmembrane transport R-HSA-425407
Drug ADME R-HSA-9748784
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Transport of small molecules R-HSA-382551
Ciprofloxacin ADME R-HSA-9793528
SLC-mediated transmembrane transport R-HSA-425407
Drug ADME R-HSA-9748784
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
Ciprofloxacin ADME R-HSA-9793528
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551

Expression Atlas ENSG00000149452
NCBI gene (formerly Entrezgene) 9376
GeneCards 10972
HGNC Symbol HGNC:10972
MIM gene 607581
UniProtKB Gene Name Q8TCC7
WikiGene 9376
Ensembl ID : ENSG00000168065
Description: solute carrier family 22 member 11
Gene Synonyms: OAT4
1 APIs:
891 Possible Orthologues:

Organic anion transport R-HSA-561048
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of small molecules R-HSA-382551
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
SLC-mediated transmembrane transport R-HSA-425407
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Transport of small molecules R-HSA-382551
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic anion transport R-HSA-561048
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
Organic cation/anion/zwitterion transport R-HSA-549132
SLC-mediated transmembrane transport R-HSA-425407
Transport of small molecules R-HSA-382551
Organic anion transport R-HSA-561048
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Organic cation/anion/zwitterion transport R-HSA-549132
Organic cation/anion/zwitterion transport R-HSA-549132
Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425366
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Organic anion transport R-HSA-561048

Expression Atlas ENSG00000168065
NCBI gene (formerly Entrezgene) 55867
GeneCards 18120
HGNC Symbol HGNC:18120
MIM gene 607097
UniProtKB Gene Name Q9NSA0
WikiGene 55867
Gene: SLC29A1
Ensembl ID : ENSG00000112759
Description: solute carrier family 29 member 1 (Augustine blood group)
Gene Synonyms: ENT1
1 APIs:
280 Possible Orthologues:

Azathioprine ADME R-HSA-9748787
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
SLC-mediated transmembrane transport R-HSA-425407
Ribavirin ADME R-HSA-9755088
Transport of small molecules R-HSA-382551
Drug ADME R-HSA-9748784
SLC-mediated transmembrane transport R-HSA-425407
Ribavirin ADME R-HSA-9755088
Drug ADME R-HSA-9748784
Azathioprine ADME R-HSA-9748787
Transport of small molecules R-HSA-382551
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of small molecules R-HSA-382551
Azathioprine ADME R-HSA-9748787
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Drug ADME R-HSA-9748784
Ribavirin ADME R-HSA-9755088
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Drug ADME R-HSA-9748784
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Azathioprine ADME R-HSA-9748787
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Ribavirin ADME R-HSA-9755088
SLC-mediated transmembrane transport R-HSA-425407
Azathioprine ADME R-HSA-9748787
Transport of small molecules R-HSA-382551
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Drug ADME R-HSA-9748784
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Ribavirin ADME R-HSA-9755088
Azathioprine ADME R-HSA-9748787
Drug ADME R-HSA-9748784
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Ribavirin ADME R-HSA-9755088
Drug ADME R-HSA-9748784
Azathioprine ADME R-HSA-9748787
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of small molecules R-HSA-382551
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
SLC-mediated transmembrane transport R-HSA-425407
Drug ADME R-HSA-9748784
Transport of small molecules R-HSA-382551
Azathioprine ADME R-HSA-9748787
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Drug ADME R-HSA-9748784
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
SLC-mediated transmembrane transport R-HSA-425407
Azathioprine ADME R-HSA-9748787
Transport of small molecules R-HSA-382551
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Transport of small molecules R-HSA-382551
Drug ADME R-HSA-9748784
Ribavirin ADME R-HSA-9755088
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Azathioprine ADME R-HSA-9748787
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-83936
Drug ADME R-HSA-9748784
Azathioprine ADME R-HSA-9748787
SLC-mediated transmembrane transport R-HSA-425407
Transport of vitamins, nucleosides, and related molecules R-HSA-425397
Ribavirin ADME R-HSA-9755088
Transport of small molecules R-HSA-382551

Expression Atlas ENSG00000112759
LRG display in Ensembl gene LRG_1027
NCBI gene (formerly Entrezgene) 2030
GeneCards 11003
HGNC Symbol HGNC:11003
MIM gene 602193
UniProtKB Gene Name Q99808
WikiGene 2030
Gene: MAP3K12
Ensembl ID : ENSG00000139625
Description: mitogen-activated protein kinase kinase kinase 12
Gene Synonyms: DLK,MEKK12,MUK,ZPK,ZPKP1
1 APIs:
254 Possible Orthologues:

Expression Atlas ENSG00000139625
NCBI gene (formerly Entrezgene) 7786
GeneCards 6851
HGNC Symbol HGNC:6851
MIM gene 600447
UniProtKB Gene Name Q12852
WikiGene 7786
Gene: PAK4
Ensembl ID : ENSG00000130669
Description: p21 (RAC1) activated kinase 4
Gene Synonyms:
1 APIs:
160 Possible Orthologues:

RHOV GTPase cycle R-HSA-9013424
RHOH GTPase cycle R-HSA-9013407
Developmental Biology R-HSA-1266738
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
Activation of RAC1 R-HSA-428540
RAC2 GTPase cycle R-HSA-9013404
RHO GTPase cycle R-HSA-9012999
Nervous system development R-HSA-9675108
RHOJ GTPase cycle R-HSA-9013409
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHOQ GTPase cycle R-HSA-9013406
Signal Transduction R-HSA-162582
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
RHOG GTPase cycle R-HSA-9013408
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC2 GTPase cycle R-HSA-9013404
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
RHOV GTPase cycle R-HSA-9013424
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
Developmental Biology R-HSA-1266738
Activation of RAC1 R-HSA-428540
CDC42 GTPase cycle R-HSA-9013148
RHOU GTPase cycle R-HSA-9013420
RAC1 GTPase cycle R-HSA-9013149
RHOJ GTPase cycle R-HSA-9013409
Signaling by ROBO receptors R-HSA-376176
RHOH GTPase cycle R-HSA-9013407
RHOQ GTPase cycle R-HSA-9013406
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
RHOJ GTPase cycle R-HSA-9013409
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
RHOG GTPase cycle R-HSA-9013408
RHOV GTPase cycle R-HSA-9013424
CDC42 GTPase cycle R-HSA-9013148
Signal Transduction R-HSA-162582
RAC2 GTPase cycle R-HSA-9013404
RHO GTPase cycle R-HSA-9012999
Nervous system development R-HSA-9675108
RHOQ GTPase cycle R-HSA-9013406
RHOU GTPase cycle R-HSA-9013420
Activation of RAC1 R-HSA-428540
Signaling by ROBO receptors R-HSA-376176
RHOH GTPase cycle R-HSA-9013407
Axon guidance R-HSA-422475
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
RHOJ GTPase cycle R-HSA-9013409
RHO GTPase cycle R-HSA-9012999
Activation of RAC1 R-HSA-428540
RAC1 GTPase cycle R-HSA-9013149
RAC3 GTPase cycle R-HSA-9013423
RHOG GTPase cycle R-HSA-9013408
RHOH GTPase cycle R-HSA-9013407
Signaling by Rho GTPases R-HSA-194315
Nervous system development R-HSA-9675108
RAC2 GTPase cycle R-HSA-9013404
Signal Transduction R-HSA-162582
Signaling by ROBO receptors R-HSA-376176
Developmental Biology R-HSA-1266738
RHOV GTPase cycle R-HSA-9013424
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOU GTPase cycle R-HSA-9013420
RHOQ GTPase cycle R-HSA-9013406
Signal Transduction R-HSA-162582
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC2 GTPase cycle R-HSA-9013404
RHOH GTPase cycle R-HSA-9013407
Activation of RAC1 R-HSA-428540
Signaling by Rho GTPases R-HSA-194315
RAC1 GTPase cycle R-HSA-9013149
RHOG GTPase cycle R-HSA-9013408
RHOV GTPase cycle R-HSA-9013424
RHOU GTPase cycle R-HSA-9013420
RHOJ GTPase cycle R-HSA-9013409
RAC3 GTPase cycle R-HSA-9013423
RHO GTPase cycle R-HSA-9012999
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
RHOQ GTPase cycle R-HSA-9013406
RAC3 GTPase cycle R-HSA-9013423
Signaling by ROBO receptors R-HSA-376176
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
Signaling by Rho GTPases R-HSA-194315
CDC42 GTPase cycle R-HSA-9013148
RAC1 GTPase cycle R-HSA-9013149
RHOJ GTPase cycle R-HSA-9013409
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Activation of RAC1 R-HSA-428540
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
RHOV GTPase cycle R-HSA-9013424
RHOQ GTPase cycle R-HSA-9013406
RAC2 GTPase cycle R-HSA-9013404
RHOH GTPase cycle R-HSA-9013407
RHO GTPase cycle R-HSA-9012999
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RHOQ GTPase cycle R-HSA-9013406
Activation of RAC1 R-HSA-428540
RHOG GTPase cycle R-HSA-9013408
RHOH GTPase cycle R-HSA-9013407
RHOU GTPase cycle R-HSA-9013420
Signal Transduction R-HSA-162582
RAC2 GTPase cycle R-HSA-9013404
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases R-HSA-194315
Nervous system development R-HSA-9675108
RHOJ GTPase cycle R-HSA-9013409
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOV GTPase cycle R-HSA-9013424
RAC3 GTPase cycle R-HSA-9013423
Axon guidance R-HSA-422475
RHOQ GTPase cycle R-HSA-9013406
RHOH GTPase cycle R-HSA-9013407
CDC42 GTPase cycle R-HSA-9013148
Nervous system development R-HSA-9675108
Activation of RAC1 R-HSA-428540
RAC3 GTPase cycle R-HSA-9013423
Signal Transduction R-HSA-162582
Signaling by ROBO receptors R-HSA-376176
RHOV GTPase cycle R-HSA-9013424
RHOG GTPase cycle R-HSA-9013408
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHO GTPase cycle R-HSA-9012999
RHOJ GTPase cycle R-HSA-9013409
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases R-HSA-194315
RAC1 GTPase cycle R-HSA-9013149
RHOU GTPase cycle R-HSA-9013420
RAC2 GTPase cycle R-HSA-9013404
Axon guidance R-HSA-422475
RHOU GTPase cycle R-HSA-9013420
RAC1 GTPase cycle R-HSA-9013149
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
Developmental Biology R-HSA-1266738
RHOJ GTPase cycle R-HSA-9013409
Activation of RAC1 R-HSA-428540
Signal Transduction R-HSA-162582
RHOH GTPase cycle R-HSA-9013407
RHOQ GTPase cycle R-HSA-9013406
RAC2 GTPase cycle R-HSA-9013404
RHOG GTPase cycle R-HSA-9013408
RAC3 GTPase cycle R-HSA-9013423
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RHOV GTPase cycle R-HSA-9013424
Nervous system development R-HSA-9675108

Expression Atlas ENSG00000130669
NCBI gene (formerly Entrezgene) 10298
GeneCards 16059
HGNC Symbol HGNC:16059
MIM gene 605451
UniProtKB Gene Name O96013
WikiGene 10298
Gene: MAP2K1
Ensembl ID : ENSG00000169032
Description: mitogen-activated protein kinase kinase 1
Gene Synonyms: MAPKK1,MEK1,PRKMK1
20 APIs:
203 Possible Orthologues:

Oncogenic MAPK signaling R-HSA-6802957
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Disease R-HSA-1643685
Signalling to ERKs R-HSA-187687
Axon guidance R-HSA-422475
MAP2K and MAPK activation R-HSA-5674135
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
L1CAM interactions R-HSA-373760
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll-like Receptor Cascades R-HSA-168898
Signaling downstream of RAS mutants R-HSA-9649948
Innate Immune System R-HSA-168249
RAF activation R-HSA-5673000
Signaling by NTRKs R-HSA-166520
MAPK3 (ERK1) activation R-HSA-110056
Uptake and function of anthrax toxins R-HSA-5210891
MyD88 cascade initiated on plasma membrane R-HSA-975871
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Nervous system development R-HSA-9675108
Prolonged ERK activation events R-HSA-169893
MAPK family signaling cascades R-HSA-5683057
Immune System R-HSA-168256
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative feedback regulation of MAPK pathway R-HSA-5674499
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Developmental Biology R-HSA-1266738
RAF-independent MAPK1/3 activation R-HSA-112409
Signal transduction by L1 R-HSA-445144
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Negative regulation of MAPK pathway R-HSA-5675221
Signal Transduction R-HSA-162582
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Infectious disease R-HSA-5663205
Cytokine Signaling in Immune system R-HSA-1280215
MyD88-independent TLR4 cascade R-HSA-166166
RAF/MAP kinase cascade R-HSA-5673001
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Uptake and actions of bacterial toxins R-HSA-5339562
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Frs2-mediated activation R-HSA-170968
Signaling by MAP2K mutants R-HSA-9652169
Interleukin-1 signaling R-HSA-9020702
Signaling by RAF1 mutants R-HSA-9656223
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Oncogenic MAPK signaling R-HSA-6802957
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
MAP kinase activation R-HSA-450294
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by RAS mutants R-HSA-6802949
MyD88 dependent cascade initiated on endosome R-HSA-975155
Uptake and function of anthrax toxins R-HSA-5210891
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Infectious disease R-HSA-5663205
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of MAPK pathway R-HSA-5675221
Axon guidance R-HSA-422475
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MyD88 cascade initiated on plasma membrane R-HSA-975871
L1CAM interactions R-HSA-373760
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signal transduction by L1 R-HSA-445144
Signalling to ERKs R-HSA-187687
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by RAF1 mutants R-HSA-9656223
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MAPK family signaling cascades R-HSA-5683057
MAPK3 (ERK1) activation R-HSA-110056
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signal Transduction R-HSA-162582
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Interleukin-1 family signaling R-HSA-446652
Interleukin-17 signaling R-HSA-448424
Cytokine Signaling in Immune system R-HSA-1280215
MyD88-independent TLR4 cascade R-HSA-166166
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Frs2-mediated activation R-HSA-170968
Negative feedback regulation of MAPK pathway R-HSA-5674499
Developmental Biology R-HSA-1266738
Interleukin-1 signaling R-HSA-9020702
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Nervous system development R-HSA-9675108
Prolonged ERK activation events R-HSA-169893
RAF activation R-HSA-5673000
Immune System R-HSA-168256
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Toll-like Receptor Cascades R-HSA-168898
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
RAF-independent MAPK1/3 activation R-HSA-112409
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling downstream of RAS mutants R-HSA-9649948
Innate Immune System R-HSA-168249
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by MAP2K mutants R-HSA-9652169
MAP kinase activation R-HSA-450294
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Immune System R-HSA-168256
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Prolonged ERK activation events R-HSA-169893
Signal transduction by L1 R-HSA-445144
Infectious disease R-HSA-5663205
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Interleukins R-HSA-449147
RAF/MAP kinase cascade R-HSA-5673001
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Axon guidance R-HSA-422475
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Negative regulation of MAPK pathway R-HSA-5675221
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
L1CAM interactions R-HSA-373760
Nervous system development R-HSA-9675108
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAPK3 (ERK1) activation R-HSA-110056
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Uptake and actions of bacterial toxins R-HSA-5339562
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
Disease R-HSA-1643685
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Cytokine Signaling in Immune system R-HSA-1280215
RAF-independent MAPK1/3 activation R-HSA-112409
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAP kinase activation R-HSA-450294
Toll-like Receptor Cascades R-HSA-168898
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-17 signaling R-HSA-448424
Frs2-mediated activation R-HSA-170968
Developmental Biology R-HSA-1266738
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling downstream of RAS mutants R-HSA-9649948
Innate Immune System R-HSA-168249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Interleukin-1 family signaling R-HSA-446652
MAP2K and MAPK activation R-HSA-5674135
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by MAP2K mutants R-HSA-9652169
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
Developmental Biology R-HSA-1266738
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
RAF-independent MAPK1/3 activation R-HSA-112409
Signal transduction by L1 R-HSA-445144
Infectious disease R-HSA-5663205
Signaling by Interleukins R-HSA-449147
Signaling by NTRKs R-HSA-166520
Signal Transduction R-HSA-162582
RAF/MAP kinase cascade R-HSA-5673001
L1CAM interactions R-HSA-373760
RAF activation R-HSA-5673000
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by NTRK1 (TRKA) R-HSA-187037
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Cytokine Signaling in Immune system R-HSA-1280215
Signaling downstream of RAS mutants R-HSA-9649948
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signalling to ERKs R-HSA-187687
MAP kinase activation R-HSA-450294
Interleukin-1 family signaling R-HSA-446652
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK family signaling cascades R-HSA-5683057
Immune System R-HSA-168256
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
Interleukin-17 signaling R-HSA-448424
Negative regulation of MAPK pathway R-HSA-5675221
MyD88 dependent cascade initiated on endosome R-HSA-975155
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by RAS mutants R-HSA-6802949
Nervous system development R-HSA-9675108
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Innate Immune System R-HSA-168249
Signaling by MAP2K mutants R-HSA-9652169
MAPK3 (ERK1) activation R-HSA-110056
Prolonged ERK activation events R-HSA-169893
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by RAF1 mutants R-HSA-9656223
Uptake and actions of bacterial toxins R-HSA-5339562
MAP2K and MAPK activation R-HSA-5674135
Interleukin-1 signaling R-HSA-9020702
Axon guidance R-HSA-422475
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Cytokine Signaling in Immune system R-HSA-1280215
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Interleukin-17 signaling R-HSA-448424
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
MAP kinase activation R-HSA-450294
Immune System R-HSA-168256
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MAPK3 (ERK1) activation R-HSA-110056
Uptake and function of anthrax toxins R-HSA-5210891
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRK1 (TRKA) R-HSA-187037
Axon guidance R-HSA-422475
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Nervous system development R-HSA-9675108
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK1/MAPK3 signaling R-HSA-5684996
Prolonged ERK activation events R-HSA-169893
L1CAM interactions R-HSA-373760
Oncogenic MAPK signaling R-HSA-6802957
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAPK family signaling cascades R-HSA-5683057
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by RAS mutants R-HSA-6802949
RAF-independent MAPK1/3 activation R-HSA-112409
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
MyD88 dependent cascade initiated on endosome R-HSA-975155
Developmental Biology R-HSA-1266738
Frs2-mediated activation R-HSA-170968
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signalling to ERKs R-HSA-187687
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative feedback regulation of MAPK pathway R-HSA-5674499
Uptake and actions of bacterial toxins R-HSA-5339562
RAF activation R-HSA-5673000
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by RAF1 mutants R-HSA-9656223
Interleukin-1 signaling R-HSA-9020702
Toll-like Receptor Cascades R-HSA-168898
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Infectious disease R-HSA-5663205
Signal Transduction R-HSA-162582
MAP2K and MAPK activation R-HSA-5674135
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by NTRKs R-HSA-166520
Signaling by MAP2K mutants R-HSA-9652169
Signal transduction by L1 R-HSA-445144
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Cytokine Signaling in Immune system R-HSA-1280215
Toll-like Receptor Cascades R-HSA-168898
MAPK3 (ERK1) activation R-HSA-110056
Axon guidance R-HSA-422475
Uptake and function of anthrax toxins R-HSA-5210891
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Interleukin-1 signaling R-HSA-9020702
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
MAPK1/MAPK3 signaling R-HSA-5684996
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
L1CAM interactions R-HSA-373760
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Nervous system development R-HSA-9675108
Prolonged ERK activation events R-HSA-169893
MyD88 cascade initiated on plasma membrane R-HSA-975871
Infectious disease R-HSA-5663205
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Developmental Biology R-HSA-1266738
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAF1 mutants R-HSA-9656223
Signaling by NTRKs R-HSA-166520
Signaling by RAS mutants R-HSA-6802949
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAPK family signaling cascades R-HSA-5683057
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
RAF-independent MAPK1/3 activation R-HSA-112409
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP2K and MAPK activation R-HSA-5674135
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Frs2-mediated activation R-HSA-170968
MAP kinase activation R-HSA-450294
Interleukin-1 family signaling R-HSA-446652
Oncogenic MAPK signaling R-HSA-6802957
Immune System R-HSA-168256
Signal transduction by L1 R-HSA-445144
RAF activation R-HSA-5673000
Disease R-HSA-1643685
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MAP2K mutants R-HSA-9652169
Innate Immune System R-HSA-168249
MyD88 dependent cascade initiated on endosome R-HSA-975155
Signaling by Interleukins R-HSA-449147
MyD88-independent TLR4 cascade R-HSA-166166
Negative regulation of MAPK pathway R-HSA-5675221
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MAPK family signaling cascades R-HSA-5683057
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRK1 (TRKA) R-HSA-187037
Signal transduction by L1 R-HSA-445144
L1CAM interactions R-HSA-373760
Signaling by NTRKs R-HSA-166520
Negative regulation of MAPK pathway R-HSA-5675221
Interleukin-17 signaling R-HSA-448424
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Nervous system development R-HSA-9675108
Signaling downstream of RAS mutants R-HSA-9649948
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MyD88 cascade initiated on plasma membrane R-HSA-975871
RAF-independent MAPK1/3 activation R-HSA-112409
Developmental Biology R-HSA-1266738
Innate Immune System R-HSA-168249
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAP2K and MAPK activation R-HSA-5674135
Uptake and function of anthrax toxins R-HSA-5210891
Prolonged ERK activation events R-HSA-169893
Signaling by RAS mutants R-HSA-6802949
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by Interleukins R-HSA-449147
Signalling to ERKs R-HSA-187687
Immune System R-HSA-168256
Signaling by RAF1 mutants R-HSA-9656223
Infectious disease R-HSA-5663205
MAPK1/MAPK3 signaling R-HSA-5684996
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by MAP2K mutants R-HSA-9652169
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MAPK3 (ERK1) activation R-HSA-110056
MAP kinase activation R-HSA-450294
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Frs2-mediated activation R-HSA-170968
Axon guidance R-HSA-422475
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Disease R-HSA-1643685
Uptake and actions of bacterial toxins R-HSA-5339562
RAF activation R-HSA-5673000
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MAP2K and MAPK activation R-HSA-5674135
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MAPK3 (ERK1) activation R-HSA-110056
Axon guidance R-HSA-422475
Nervous system development R-HSA-9675108
Negative regulation of MAPK pathway R-HSA-5675221
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signaling by RAF1 mutants R-HSA-9656223
Infectious disease R-HSA-5663205
Signaling by MAP2K mutants R-HSA-9652169
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
RAF-independent MAPK1/3 activation R-HSA-112409
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
MyD88 dependent cascade initiated on endosome R-HSA-975155
RAF activation R-HSA-5673000
Toll-like Receptor Cascades R-HSA-168898
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by RAS mutants R-HSA-6802949
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling downstream of RAS mutants R-HSA-9649948
Prolonged ERK activation events R-HSA-169893
Oncogenic MAPK signaling R-HSA-6802957
MAPK1/MAPK3 signaling R-HSA-5684996
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
MyD88 cascade initiated on plasma membrane R-HSA-975871
L1CAM interactions R-HSA-373760
Innate Immune System R-HSA-168249
MAP kinase activation R-HSA-450294
Signal transduction by L1 R-HSA-445144
Developmental Biology R-HSA-1266738
Interleukin-17 signaling R-HSA-448424
Negative feedback regulation of MAPK pathway R-HSA-5674499
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Uptake and actions of bacterial toxins R-HSA-5339562
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF/MAP kinase cascade R-HSA-5673001
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRKs R-HSA-166520
Cytokine Signaling in Immune system R-HSA-1280215
Uptake and function of anthrax toxins R-HSA-5210891
Interleukin-1 family signaling R-HSA-446652
Signaling by NTRK1 (TRKA) R-HSA-187037
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Frs2-mediated activation R-HSA-170968
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Interleukins R-HSA-449147
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Immune System R-HSA-168256
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by Interleukins R-HSA-449147
Nervous system development R-HSA-9675108
MyD88 cascade initiated on plasma membrane R-HSA-975871
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
Negative feedback regulation of MAPK pathway R-HSA-5674499
Infectious disease R-HSA-5663205
Interleukin-1 family signaling R-HSA-446652
Signaling by NTRKs R-HSA-166520
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAPK3 (ERK1) activation R-HSA-110056
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Uptake and actions of bacterial toxins R-HSA-5339562
Frs2-mediated activation R-HSA-170968
Signaling by MAP2K mutants R-HSA-9652169
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Innate Immune System R-HSA-168249
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-17 signaling R-HSA-448424
L1CAM interactions R-HSA-373760
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Negative regulation of MAPK pathway R-HSA-5675221
RAF activation R-HSA-5673000
Disease R-HSA-1643685
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP kinase activation R-HSA-450294
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAF1 mutants R-HSA-9656223
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MAPK family signaling cascades R-HSA-5683057
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Interleukin-1 signaling R-HSA-9020702
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Signal transduction by L1 R-HSA-445144
Cytokine Signaling in Immune system R-HSA-1280215
Signaling downstream of RAS mutants R-HSA-9649948
Axon guidance R-HSA-422475
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Prolonged ERK activation events R-HSA-169893
MAP2K and MAPK activation R-HSA-5674135
RAF-independent MAPK1/3 activation R-HSA-112409
Developmental Biology R-HSA-1266738
Uptake and function of anthrax toxins R-HSA-5210891
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MAPK3 (ERK1) activation R-HSA-110056
Axon guidance R-HSA-422475
MAP2K and MAPK activation R-HSA-5674135
Immune System R-HSA-168256
Interleukin-1 family signaling R-HSA-446652
Toll-like Receptor Cascades R-HSA-168898
L1CAM interactions R-HSA-373760
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Disease R-HSA-1643685
RAF activation R-HSA-5673000
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Interleukin-1 signaling R-HSA-9020702
Nervous system development R-HSA-9675108
MAP kinase activation R-HSA-450294
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Developmental Biology R-HSA-1266738
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Signaling by MAP2K mutants R-HSA-9652169
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative feedback regulation of MAPK pathway R-HSA-5674499
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling downstream of RAS mutants R-HSA-9649948
MyD88-independent TLR4 cascade R-HSA-166166
Signal transduction by L1 R-HSA-445144
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Signaling by Interleukins R-HSA-449147
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Frs2-mediated activation R-HSA-170968
Prolonged ERK activation events R-HSA-169893
Interleukin-17 signaling R-HSA-448424
Signaling by RAF1 mutants R-HSA-9656223
Negative regulation of MAPK pathway R-HSA-5675221
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signalling to ERKs R-HSA-187687
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF-independent MAPK1/3 activation R-HSA-112409
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Uptake and actions of bacterial toxins R-HSA-5339562
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by NTRKs R-HSA-166520
Axon guidance R-HSA-422475
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Interleukin-17 signaling R-HSA-448424
Negative feedback regulation of MAPK pathway R-HSA-5674499
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Negative regulation of MAPK pathway R-HSA-5675221
Oncogenic MAPK signaling R-HSA-6802957
Signal Transduction R-HSA-162582
Uptake and actions of bacterial toxins R-HSA-5339562
MAP kinase activation R-HSA-450294
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
MyD88 dependent cascade initiated on endosome R-HSA-975155
Interleukin-1 signaling R-HSA-9020702
Prolonged ERK activation events R-HSA-169893
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Immune System R-HSA-168256
MyD88-independent TLR4 cascade R-HSA-166166
RAF-independent MAPK1/3 activation R-HSA-112409
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by RAS mutants R-HSA-6802949
Infectious disease R-HSA-5663205
MAPK3 (ERK1) activation R-HSA-110056
Developmental Biology R-HSA-1266738
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll-like Receptor Cascades R-HSA-168898
MAP2K and MAPK activation R-HSA-5674135
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Cytokine Signaling in Immune system R-HSA-1280215
Innate Immune System R-HSA-168249
MAPK family signaling cascades R-HSA-5683057
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by MAP2K mutants R-HSA-9652169
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Nervous system development R-HSA-9675108
Interleukin-1 family signaling R-HSA-446652
Disease R-HSA-1643685
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by Interleukins R-HSA-449147
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Uptake and function of anthrax toxins R-HSA-5210891
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signal transduction by L1 R-HSA-445144
Frs2-mediated activation R-HSA-170968
Signalling to ERKs R-HSA-187687
L1CAM interactions R-HSA-373760
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by RAF1 mutants R-HSA-9656223

Expression Atlas ENSG00000169032
LRG display in Ensembl gene LRG_725
NCBI gene (formerly Entrezgene) 5604
GeneCards 6840
HGNC Symbol HGNC:6840
MIM gene 176872
MIM morbid 615279
UniProtKB Gene Name Q02750
WikiGene 5604