Gene: PSEN1
Ensembl ID : ENSG00000080815
Description: presenilin 1
Gene Synonyms: AD3,FAD,PS-1,PS1,PSNL1,S182
5 APIs:
202 Possible Orthologues:

Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Regulated proteolysis of p75NTR R-HSA-193692
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Death Receptor Signaling R-HSA-73887
EPH-Ephrin signaling R-HSA-2682334
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Degradation of the extracellular matrix R-HSA-1474228
Extracellular matrix organization R-HSA-1474244
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Neutrophil degranulation R-HSA-6798695
Signal Transduction R-HSA-162582
Signaling by NOTCH4 R-HSA-9013694
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Noncanonical activation of NOTCH3 R-HSA-9017802
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Axon guidance R-HSA-422475
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Signaling by NOTCH2 R-HSA-1980145
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 in Cancer R-HSA-2644603
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Noncanonical activation of NOTCH3 R-HSA-9017802
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Innate Immune System R-HSA-168249
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH2 R-HSA-1980145
Extracellular matrix organization R-HSA-1474244
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH4 R-HSA-9013694
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 R-HSA-1980143
Axon guidance R-HSA-422475
NRIF signals cell death from the nucleus R-HSA-205043
Nervous system development R-HSA-9675108
Immune System R-HSA-168256
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signal Transduction R-HSA-162582
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH R-HSA-157118
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Neutrophil degranulation R-HSA-6798695
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nuclear signaling by ERBB4 R-HSA-1251985
Nuclear signaling by ERBB4 R-HSA-1251985
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 R-HSA-1980143
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Noncanonical activation of NOTCH3 R-HSA-9017802
Disease R-HSA-1643685
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 in Cancer R-HSA-2644603
Extracellular matrix organization R-HSA-1474244
Developmental Biology R-HSA-1266738
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH4 R-HSA-9013694
Death Receptor Signaling R-HSA-73887
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH R-HSA-157118
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NRIF signals cell death from the nucleus R-HSA-205043
Neutrophil degranulation R-HSA-6798695
Nervous system development R-HSA-9675108
Immune System R-HSA-168256
Degradation of the extracellular matrix R-HSA-1474228
Innate Immune System R-HSA-168249
Death Receptor Signaling R-HSA-73887
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Immune System R-HSA-168256
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Regulated proteolysis of p75NTR R-HSA-193692
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Innate Immune System R-HSA-168249
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signal Transduction R-HSA-162582
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
p75 NTR receptor-mediated signalling R-HSA-193704
Neutrophil degranulation R-HSA-6798695
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-Ephrin signaling R-HSA-2682334
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Developmental Biology R-HSA-1266738
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH4 R-HSA-9013694
Neutrophil degranulation R-HSA-6798695
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Regulated proteolysis of p75NTR R-HSA-193692
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Innate Immune System R-HSA-168249
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Immune System R-HSA-168256
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH2 R-HSA-1980145
p75 NTR receptor-mediated signalling R-HSA-193704
Noncanonical activation of NOTCH3 R-HSA-9017802
Degradation of the extracellular matrix R-HSA-1474228
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Signaling by NOTCH R-HSA-157118
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signal Transduction R-HSA-162582
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 R-HSA-1980143
Extracellular matrix organization R-HSA-1474244
Axon guidance R-HSA-422475
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH3 R-HSA-9012852
NRIF signals cell death from the nucleus R-HSA-205043
EPH-ephrin mediated repulsion of cells R-HSA-3928665
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Immune System R-HSA-168256
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Innate Immune System R-HSA-168249
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH R-HSA-157118
Noncanonical activation of NOTCH3 R-HSA-9017802
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH1 R-HSA-1980143
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Disease R-HSA-1643685
Neutrophil degranulation R-HSA-6798695
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signal Transduction R-HSA-162582
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Regulated proteolysis of p75NTR R-HSA-193692
Neutrophil degranulation R-HSA-6798695
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 in Cancer R-HSA-2644603
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Immune System R-HSA-168256
Signaling by NOTCH3 R-HSA-9012852
p75 NTR receptor-mediated signalling R-HSA-193704
Axon guidance R-HSA-422475
Signaling by NOTCH R-HSA-157118
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signal Transduction R-HSA-162582
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Developmental Biology R-HSA-1266738
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Signaling by ERBB4 R-HSA-1236394
Extracellular matrix organization R-HSA-1474244
Innate Immune System R-HSA-168249
Degradation of the extracellular matrix R-HSA-1474228
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH2 R-HSA-1980145
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Degradation of the extracellular matrix R-HSA-1474228
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Death Receptor Signaling R-HSA-73887
NRIF signals cell death from the nucleus R-HSA-205043
Axon guidance R-HSA-422475
Nuclear signaling by ERBB4 R-HSA-1251985
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 in Cancer R-HSA-2644603
Immune System R-HSA-168256
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
EPH-Ephrin signaling R-HSA-2682334
Neutrophil degranulation R-HSA-6798695
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
p75 NTR receptor-mediated signalling R-HSA-193704
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH4 R-HSA-9013694
Innate Immune System R-HSA-168249
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nervous system development R-HSA-9675108
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signal Transduction R-HSA-162582
Signaling by NOTCH1 R-HSA-1980143
Regulated proteolysis of p75NTR R-HSA-193692
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 R-HSA-1980143
Axon guidance R-HSA-422475
Degradation of the extracellular matrix R-HSA-1474228
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Nuclear signaling by ERBB4 R-HSA-1251985
Innate Immune System R-HSA-168249
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signal Transduction R-HSA-162582
Signaling by NOTCH4 R-HSA-9013694
Extracellular matrix organization R-HSA-1474244
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nervous system development R-HSA-9675108
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
Immune System R-HSA-168256
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH R-HSA-157118
Noncanonical activation of NOTCH3 R-HSA-9017802
Neutrophil degranulation R-HSA-6798695
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Developmental Biology R-HSA-1266738
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Nervous system development R-HSA-9675108
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Degradation of the extracellular matrix R-HSA-1474228
Noncanonical activation of NOTCH3 R-HSA-9017802
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH2 R-HSA-1980145
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signal Transduction R-HSA-162582
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH1 R-HSA-1980143
Innate Immune System R-HSA-168249
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH3 R-HSA-9012852
Neutrophil degranulation R-HSA-6798695
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Extracellular matrix organization R-HSA-1474244
Immune System R-HSA-168256
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202

Expression Atlas ENSG00000080815
LRG display in Ensembl gene LRG_224
NCBI gene (formerly Entrezgene) 5663
GeneCards 9508
HGNC Symbol HGNC:9508
MIM gene 104311
MIM morbid 613737
UniProtKB Gene Name P49768
WikiGene 5663
Gene: PSEN2
Ensembl ID : ENSG00000143801
Description: presenilin 2
Gene Synonyms: AD3L,AD4,E5-1,PS-2,PS2,STM2
5 APIs:
205 Possible Orthologues:

NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH4 R-HSA-9013694
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Nervous system development R-HSA-9675108
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH3 R-HSA-9012852
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Nuclear signaling by ERBB4 R-HSA-1251985
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by ERBB4 R-HSA-1236394
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
EPH-Ephrin signaling R-HSA-2682334
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signal Transduction R-HSA-162582
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Axon guidance R-HSA-422475
Signaling by NOTCH3 R-HSA-9012852
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH2 R-HSA-1980145
p75 NTR receptor-mediated signalling R-HSA-193704
Death Receptor Signaling R-HSA-73887
EPH-Ephrin signaling R-HSA-2682334
Noncanonical activation of NOTCH3 R-HSA-9017802
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Developmental Biology R-HSA-1266738
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NRIF signals cell death from the nucleus R-HSA-205043
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH4 R-HSA-9013694
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH2 R-HSA-1980145
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Noncanonical activation of NOTCH3 R-HSA-9017802
Axon guidance R-HSA-422475
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
NRIF signals cell death from the nucleus R-HSA-205043
Disease R-HSA-1643685
Nervous system development R-HSA-9675108
Death Receptor Signaling R-HSA-73887
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Developmental Biology R-HSA-1266738
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 in Cancer R-HSA-2644603
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
p75 NTR receptor-mediated signalling R-HSA-193704
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
Regulated proteolysis of p75NTR R-HSA-193692
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Axon guidance R-HSA-422475
Signaling by ERBB4 R-HSA-1236394
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH2 R-HSA-1980145
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
Nuclear signaling by ERBB4 R-HSA-1251985
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Disease R-HSA-1643685
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Noncanonical activation of NOTCH3 R-HSA-9017802
p75 NTR receptor-mediated signalling R-HSA-193704
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH2 R-HSA-1980145
Signal Transduction R-HSA-162582
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Noncanonical activation of NOTCH3 R-HSA-9017802
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH4 R-HSA-9013694
Signal Transduction R-HSA-162582
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Axon guidance R-HSA-422475
Nervous system development R-HSA-9675108
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Developmental Biology R-HSA-1266738
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nuclear signaling by ERBB4 R-HSA-1251985
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-Ephrin signaling R-HSA-2682334
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603
Noncanonical activation of NOTCH3 R-HSA-9017802
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH3 R-HSA-9012852
Nervous system development R-HSA-9675108
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Death Receptor Signaling R-HSA-73887
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by ERBB4 R-HSA-1236394
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nervous system development R-HSA-9675108
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Axon guidance R-HSA-422475
Signaling by NOTCH3 R-HSA-9012852
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH2 R-HSA-1980145
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Developmental Biology R-HSA-1266738
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nuclear signaling by ERBB4 R-HSA-1251985
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 in Cancer R-HSA-2644603
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Disease R-HSA-1643685
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by ERBB4 R-HSA-1236394
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH4 R-HSA-9013694
Nuclear signaling by ERBB4 R-HSA-1251985
Death Receptor Signaling R-HSA-73887
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096

Expression Atlas ENSG00000143801
LRG display in Ensembl gene LRG_225
NCBI gene (formerly Entrezgene) 5664
GeneCards 9509
HGNC Symbol HGNC:9509
MIM gene 600759
MIM morbid 613697
UniProtKB Gene Name P49810
WikiGene 5664
Gene: APH1B
Ensembl ID : ENSG00000138613
Description: aph-1 homolog B, gamma-secretase subunit
Gene Synonyms: APH-1B,DKFZP564D0372,PSFL
5 APIs:
193 Possible Orthologues:

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH4 R-HSA-9013694
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Developmental Biology R-HSA-1266738
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Axon guidance R-HSA-422475
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH2 R-HSA-1980145
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NRIF signals cell death from the nucleus R-HSA-205043
Regulated proteolysis of p75NTR R-HSA-193692
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Metabolism of proteins R-HSA-392499
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Nuclear signaling by ERBB4 R-HSA-1251985
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH1 in Cancer R-HSA-2644603
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH4 R-HSA-9013694
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
p75 NTR receptor-mediated signalling R-HSA-193704
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Axon guidance R-HSA-422475
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Metabolism of proteins R-HSA-392499
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Regulated proteolysis of p75NTR R-HSA-193692
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
NRIF signals cell death from the nucleus R-HSA-205043
Noncanonical activation of NOTCH3 R-HSA-9017802
Nervous system development R-HSA-9675108
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Metabolism of proteins R-HSA-392499
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Regulated proteolysis of p75NTR R-HSA-193692
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
NRIF signals cell death from the nucleus R-HSA-205043
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Disease R-HSA-1643685
Signaling by NOTCH1 R-HSA-1980143
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH4 R-HSA-9013694
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH4 R-HSA-9013694
Regulated proteolysis of p75NTR R-HSA-193692
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
p75 NTR receptor-mediated signalling R-HSA-193704
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Signaling by NOTCH2 R-HSA-1980145
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH3 R-HSA-9012852
Death Receptor Signaling R-HSA-73887
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NRIF signals cell death from the nucleus R-HSA-205043
Developmental Biology R-HSA-1266738
Amyloid fiber formation R-HSA-977225
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by ERBB4 R-HSA-1236394
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Nuclear signaling by ERBB4 R-HSA-1251985
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Amyloid fiber formation R-HSA-977225
Nervous system development R-HSA-9675108
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Nuclear signaling by ERBB4 R-HSA-1251985
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Developmental Biology R-HSA-1266738
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH R-HSA-157118
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 in Cancer R-HSA-2644603
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signal Transduction R-HSA-162582
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 R-HSA-1980143
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nervous system development R-HSA-9675108
Signaling by NOTCH1 in Cancer R-HSA-2644603
Regulated proteolysis of p75NTR R-HSA-193692
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH R-HSA-157118
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH2 R-HSA-1980145
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Axon guidance R-HSA-422475
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Metabolism of proteins R-HSA-392499
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH2 R-HSA-1980145
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH R-HSA-157118
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Amyloid fiber formation R-HSA-977225
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH2 R-HSA-1980145
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signal Transduction R-HSA-162582
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH4 R-HSA-9013694
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 in Cancer R-HSA-2644603
Noncanonical activation of NOTCH3 R-HSA-9017802
Metabolism of proteins R-HSA-392499
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Amyloid fiber formation R-HSA-977225
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Amyloid fiber formation R-HSA-977225
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nervous system development R-HSA-9675108
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Regulated proteolysis of p75NTR R-HSA-193692
Noncanonical activation of NOTCH3 R-HSA-9017802
Signal Transduction R-HSA-162582
Nuclear signaling by ERBB4 R-HSA-1251985
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH3 R-HSA-9012852
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
NRIF signals cell death from the nucleus R-HSA-205043
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Signaling by NOTCH4 R-HSA-9013694
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH2 R-HSA-1980145

Expression Atlas ENSG00000138613
NCBI gene (formerly Entrezgene) 83464
GeneCards 24080
HGNC Symbol HGNC:24080
MIM gene 607630
UniProtKB Gene Name Q8WW43
WikiGene 83464
Gene: APH1A
Ensembl ID : ENSG00000117362
Description: aph-1 homolog A, gamma-secretase subunit
Gene Synonyms: APH-1A,CGI-78
5 APIs:
138 Possible Orthologues:

Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 in Cancer R-HSA-2644603
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH2 R-HSA-1980145
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
Nuclear signaling by ERBB4 R-HSA-1251985
Amyloid fiber formation R-HSA-977225
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH3 R-HSA-9012852
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism of proteins R-HSA-392499
Developmental Biology R-HSA-1266738
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Amyloid fiber formation R-HSA-977225
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 in Cancer R-HSA-2644603
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
Signaling by NOTCH1 R-HSA-1980143
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH3 R-HSA-9012852
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH4 R-HSA-9013694
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
p75 NTR receptor-mediated signalling R-HSA-193704
Death Receptor Signaling R-HSA-73887
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
Regulated proteolysis of p75NTR R-HSA-193692
Nuclear signaling by ERBB4 R-HSA-1251985
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH3 R-HSA-9012852
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nervous system development R-HSA-9675108
Signaling by NOTCH4 R-HSA-9013694
Axon guidance R-HSA-422475
Signaling by ERBB4 R-HSA-1236394
EPH-Ephrin signaling R-HSA-2682334
Amyloid fiber formation R-HSA-977225
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH1 R-HSA-1980143
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Regulated proteolysis of p75NTR R-HSA-193692
Disease R-HSA-1643685
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH1 in Cancer R-HSA-2644603
EPH-ephrin mediated repulsion of cells R-HSA-3928665
p75 NTR receptor-mediated signalling R-HSA-193704
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
Metabolism of proteins R-HSA-392499
Nervous system development R-HSA-9675108
Signaling by NOTCH2 R-HSA-1980145
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Developmental Biology R-HSA-1266738
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Regulated proteolysis of p75NTR R-HSA-193692
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Nuclear signaling by ERBB4 R-HSA-1251985
Signal Transduction R-HSA-162582
Axon guidance R-HSA-422475
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by ERBB4 R-HSA-1236394
Noncanonical activation of NOTCH3 R-HSA-9017802
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
EPH-Ephrin signaling R-HSA-2682334
Metabolism of proteins R-HSA-392499
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Regulated proteolysis of p75NTR R-HSA-193692
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH2 R-HSA-1980145
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Nervous system development R-HSA-9675108
Death Receptor Signaling R-HSA-73887
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by ERBB4 R-HSA-1236394
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Developmental Biology R-HSA-1266738
Noncanonical activation of NOTCH3 R-HSA-9017802
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by ERBB4 R-HSA-1236394
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH4 R-HSA-9013694
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 R-HSA-1980143
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH3 R-HSA-9012852
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH R-HSA-157118
Axon guidance R-HSA-422475
Signaling by NOTCH2 R-HSA-1980145
Death Receptor Signaling R-HSA-73887
Amyloid fiber formation R-HSA-977225
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Metabolism of proteins R-HSA-392499
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Developmental Biology R-HSA-1266738
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 R-HSA-1980143
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH3 R-HSA-9012852
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH2 R-HSA-1980145
NRIF signals cell death from the nucleus R-HSA-205043
Signal Transduction R-HSA-162582
Regulated proteolysis of p75NTR R-HSA-193692
Nuclear signaling by ERBB4 R-HSA-1251985
Disease R-HSA-1643685
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Noncanonical activation of NOTCH3 R-HSA-9017802
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Axon guidance R-HSA-422475
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH1 in Cancer R-HSA-2644603
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Signal Transduction R-HSA-162582
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Nervous system development R-HSA-9675108
Metabolism of proteins R-HSA-392499
Regulated proteolysis of p75NTR R-HSA-193692
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
NRIF signals cell death from the nucleus R-HSA-205043
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH2 R-HSA-1980145
Developmental Biology R-HSA-1266738
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 R-HSA-1980143
Regulated proteolysis of p75NTR R-HSA-193692
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH2 R-HSA-1980145
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Axon guidance R-HSA-422475
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Metabolism of proteins R-HSA-392499
Signaling by ERBB4 R-HSA-1236394
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Amyloid fiber formation R-HSA-977225
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH4 R-HSA-9013694
Death Receptor Signaling R-HSA-73887
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
EPH-Ephrin signaling R-HSA-2682334
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nervous system development R-HSA-9675108
Nuclear signaling by ERBB4 R-HSA-1251985
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Axon guidance R-HSA-422475
Signaling by NOTCH1 in Cancer R-HSA-2644603
Amyloid fiber formation R-HSA-977225
Developmental Biology R-HSA-1266738
EPH-Ephrin signaling R-HSA-2682334
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-ephrin mediated repulsion of cells R-HSA-3928665
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH R-HSA-157118
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NRIF signals cell death from the nucleus R-HSA-205043
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH2 R-HSA-1980145
Signal Transduction R-HSA-162582
Death Receptor Signaling R-HSA-73887
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
Metabolism of proteins R-HSA-392499
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Amyloid fiber formation R-HSA-977225
Nervous system development R-HSA-9675108
Metabolism of proteins R-HSA-392499
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Nuclear signaling by ERBB4 R-HSA-1251985
p75 NTR receptor-mediated signalling R-HSA-193704
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
EPH-Ephrin signaling R-HSA-2682334
Disease R-HSA-1643685
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH4 R-HSA-9013694
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH2 R-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Axon guidance R-HSA-422475
Death Receptor Signaling R-HSA-73887

Expression Atlas ENSG00000117362
NCBI gene (formerly Entrezgene) 51107
GeneCards 29509
HGNC Symbol HGNC:29509
MIM gene 607629
UniProtKB Gene Name Q96BI3
WikiGene 51107
Gene: NCSTN
Ensembl ID : ENSG00000162736
Description: nicastrin
Gene Synonyms: APH2,KIAA0253
5 APIs:
204 Possible Orthologues:

Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Death Receptor Signaling R-HSA-73887
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH3 R-HSA-9012852
Nervous system development R-HSA-9675108
Amyloid fiber formation R-HSA-977225
Noncanonical activation of NOTCH3 R-HSA-9017802
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 in Cancer R-HSA-2644603
Extracellular matrix organization R-HSA-1474244
Degradation of the extracellular matrix R-HSA-1474228
Signal Transduction R-HSA-162582
Metabolism of proteins R-HSA-392499
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulated proteolysis of p75NTR R-HSA-193692
Disease R-HSA-1643685
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Signaling by NOTCH1 R-HSA-1980143
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Neutrophil degranulation R-HSA-6798695
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
Signaling by NOTCH4 R-HSA-9013694
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Immune System R-HSA-168256
Signaling by ERBB4 R-HSA-1236394
Innate Immune System R-HSA-168249
Axon guidance R-HSA-422475
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH4 R-HSA-9013694
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by ERBB4 R-HSA-1236394
Neutrophil degranulation R-HSA-6798695
Amyloid fiber formation R-HSA-977225
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH1 in Cancer R-HSA-2644603
Death Receptor Signaling R-HSA-73887
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Developmental Biology R-HSA-1266738
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Innate Immune System R-HSA-168249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Immune System R-HSA-168256
Nuclear signaling by ERBB4 R-HSA-1251985
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH3 R-HSA-9012852
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Axon guidance R-HSA-422475
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Nervous system development R-HSA-9675108
Extracellular matrix organization R-HSA-1474244
Degradation of the extracellular matrix R-HSA-1474228
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH3 R-HSA-9012852
EPH-Ephrin signaling R-HSA-2682334
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Degradation of the extracellular matrix R-HSA-1474228
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Neutrophil degranulation R-HSA-6798695
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
p75 NTR receptor-mediated signalling R-HSA-193704
Noncanonical activation of NOTCH3 R-HSA-9017802
Regulated proteolysis of p75NTR R-HSA-193692
Death Receptor Signaling R-HSA-73887
Signaling by ERBB4 R-HSA-1236394
Amyloid fiber formation R-HSA-977225
Disease R-HSA-1643685
Innate Immune System R-HSA-168249
Nuclear signaling by ERBB4 R-HSA-1251985
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
NRIF signals cell death from the nucleus R-HSA-205043
Metabolism of proteins R-HSA-392499
Signaling by NOTCH R-HSA-157118
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH4 R-HSA-9013694
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH2 R-HSA-1980145
Immune System R-HSA-168256
Signaling by NOTCH1 in Cancer R-HSA-2644603
Axon guidance R-HSA-422475
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Nuclear signaling by ERBB4 R-HSA-1251985
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Axon guidance R-HSA-422475
NRIF signals cell death from the nucleus R-HSA-205043
Signal Transduction R-HSA-162582
p75 NTR receptor-mediated signalling R-HSA-193704
Degradation of the extracellular matrix R-HSA-1474228
Disease R-HSA-1643685
Neutrophil degranulation R-HSA-6798695
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
EPH-Ephrin signaling R-HSA-2682334
Death Receptor Signaling R-HSA-73887
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Immune System R-HSA-168256
Nervous system development R-HSA-9675108
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Amyloid fiber formation R-HSA-977225
Signaling by NOTCH4 R-HSA-9013694
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH2 R-HSA-1980145
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Extracellular matrix organization R-HSA-1474244
Developmental Biology R-HSA-1266738
Regulated proteolysis of p75NTR R-HSA-193692
p75 NTR receptor-mediated signalling R-HSA-193704
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Noncanonical activation of NOTCH3 R-HSA-9017802
Regulated proteolysis of p75NTR R-HSA-193692
Neutrophil degranulation R-HSA-6798695
Nervous system development R-HSA-9675108
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
NRIF signals cell death from the nucleus R-HSA-205043
Death Receptor Signaling R-HSA-73887
Axon guidance R-HSA-422475
Disease R-HSA-1643685
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 R-HSA-1980143
Metabolism of proteins R-HSA-392499
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Developmental Biology R-HSA-1266738
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH4 R-HSA-9013694
Nuclear signaling by ERBB4 R-HSA-1251985
Immune System R-HSA-168256
EPH-Ephrin signaling R-HSA-2682334
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH2 R-HSA-1980145
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Innate Immune System R-HSA-168249
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Amyloid fiber formation R-HSA-977225
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Degradation of the extracellular matrix R-HSA-1474228
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Regulated proteolysis of p75NTR R-HSA-193692
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-Ephrin signaling R-HSA-2682334
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by ERBB4 R-HSA-1236394
Metabolism of proteins R-HSA-392499
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
NRIF signals cell death from the nucleus R-HSA-205043
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH R-HSA-157118
Axon guidance R-HSA-422475
Amyloid fiber formation R-HSA-977225
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Extracellular matrix organization R-HSA-1474244
Immune System R-HSA-168256
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH4 R-HSA-9013694
Developmental Biology R-HSA-1266738
Degradation of the extracellular matrix R-HSA-1474228
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Neutrophil degranulation R-HSA-6798695
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Noncanonical activation of NOTCH3 R-HSA-9017802
p75 NTR receptor-mediated signalling R-HSA-193704
Signaling by NOTCH3 R-HSA-9012852
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
Innate Immune System R-HSA-168249
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
Signaling by NOTCH1 R-HSA-1980143
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Innate Immune System R-HSA-168249
Nervous system development R-HSA-9675108
p75 NTR receptor-mediated signalling R-HSA-193704
Death Receptor Signaling R-HSA-73887
Noncanonical activation of NOTCH3 R-HSA-9017802
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Axon guidance R-HSA-422475
EPH-Ephrin signaling R-HSA-2682334
Metabolism of proteins R-HSA-392499
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Disease R-HSA-1643685
Signaling by NOTCH R-HSA-157118
Signaling by ERBB4 R-HSA-1236394
Signaling by NOTCH4 R-HSA-9013694
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH2 R-HSA-1980145
NRIF signals cell death from the nucleus R-HSA-205043
Amyloid fiber formation R-HSA-977225
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH1 in Cancer R-HSA-2644603
Regulated proteolysis of p75NTR R-HSA-193692
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by NOTCH3 R-HSA-9012852
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Extracellular matrix organization R-HSA-1474244
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Degradation of the extracellular matrix R-HSA-1474228
Nuclear signaling by ERBB4 R-HSA-1251985
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Immune System R-HSA-168256
p75 NTR receptor-mediated signalling R-HSA-193704
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Regulated proteolysis of p75NTR R-HSA-193692
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 in Cancer R-HSA-2644603
Amyloid fiber formation R-HSA-977225
Developmental Biology R-HSA-1266738
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH2 R-HSA-1980145
Nervous system development R-HSA-9675108
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Noncanonical activation of NOTCH3 R-HSA-9017802
Axon guidance R-HSA-422475
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
NRIF signals cell death from the nucleus R-HSA-205043
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Signaling by NOTCH1 R-HSA-1980143
Death Receptor Signaling R-HSA-73887
Degradation of the extracellular matrix R-HSA-1474228
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
p75 NTR receptor-mediated signalling R-HSA-193704
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH3 R-HSA-9012852
Death Receptor Signaling R-HSA-73887
Innate Immune System R-HSA-168249
Noncanonical activation of NOTCH3 R-HSA-9017802
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by ERBB4 R-HSA-1236394
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signaling by NOTCH4 R-HSA-9013694
Regulated proteolysis of p75NTR R-HSA-193692
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH R-HSA-157118
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Extracellular matrix organization R-HSA-1474244
Neutrophil degranulation R-HSA-6798695
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Disease R-HSA-1643685
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Signaling by NOTCH1 in Cancer R-HSA-2644603
Signal Transduction R-HSA-162582
NRIF signals cell death from the nucleus R-HSA-205043
Amyloid fiber formation R-HSA-977225
Nuclear signaling by ERBB4 R-HSA-1251985
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Metabolism of proteins R-HSA-392499
Immune System R-HSA-168256
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NOTCH2 R-HSA-1980145
Axon guidance R-HSA-422475
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Innate Immune System R-HSA-168249
Metabolism of proteins R-HSA-392499
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
NRIF signals cell death from the nucleus R-HSA-205043
Neutrophil degranulation R-HSA-6798695
Degradation of the extracellular matrix R-HSA-1474228
Signaling by NOTCH3 R-HSA-9012852
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Death Receptor Signaling R-HSA-73887
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 R-HSA-1980143
Signaling by ERBB4 R-HSA-1236394
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH1 in Cancer R-HSA-2644603
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Disease R-HSA-1643685
Noncanonical activation of NOTCH3 R-HSA-9017802
EPH-ephrin mediated repulsion of cells R-HSA-3928665
p75 NTR receptor-mediated signalling R-HSA-193704
Nervous system development R-HSA-9675108
EPH-Ephrin signaling R-HSA-2682334
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Signal Transduction R-HSA-162582
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Developmental Biology R-HSA-1266738
Signaling by NOTCH R-HSA-157118
Amyloid fiber formation R-HSA-977225
Nuclear signaling by ERBB4 R-HSA-1251985
Regulated proteolysis of p75NTR R-HSA-193692
Immune System R-HSA-168256
Signaling by NOTCH4 R-HSA-9013694
Extracellular matrix organization R-HSA-1474244
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948
Signaling by NOTCH4 R-HSA-9013694
Cell death signalling via NRAGE, NRIF and NADE R-HSA-204998
Noncanonical activation of NOTCH3 R-HSA-9017802
Death Receptor Signaling R-HSA-73887
NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9013700
Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606
Amyloid fiber formation R-HSA-977225
Immune System R-HSA-168256
Nervous system development R-HSA-9675108
NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-2979096
Degradation of the extracellular matrix R-HSA-1474228
p75 NTR receptor-mediated signalling R-HSA-193704
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
EPH-ephrin mediated repulsion of cells R-HSA-3928665
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602
Signaling by NOTCH1 R-HSA-1980143
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB4 R-HSA-1236394
Metabolism of proteins R-HSA-392499
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862
Developmental Biology R-HSA-1266738
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Regulated proteolysis of p75NTR R-HSA-193692
NRIF signals cell death from the nucleus R-HSA-205043
Neutrophil degranulation R-HSA-6798695
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EPH-Ephrin signaling R-HSA-2682334
Nuclear signaling by ERBB4 R-HSA-1251985
Extracellular matrix organization R-HSA-1474244
Signaling by NOTCH2 R-HSA-1980145
Signaling by NOTCH1 in Cancer R-HSA-2644603

Expression Atlas ENSG00000162736
LRG display in Ensembl gene LRG_223
NCBI gene (formerly Entrezgene) 23385
GeneCards 17091
HGNC Symbol HGNC:17091
MIM gene 605254
MIM morbid 142690
UniProtKB Gene Name Q92542
WikiGene 23385
Gene: ATR
Ensembl ID : ENSG00000175054
Description: ATR serine/threonine kinase
Gene Synonyms: FRP1,MEC1,SCKL,SCKL1
4 APIs:
207 Possible Orthologues:

Disease R-HSA-1643685
Cell Cycle Checkpoints R-HSA-69620
Cellular response to heat stress R-HSA-3371556
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by TP53 R-HSA-3700989
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Diseases of DNA repair R-HSA-9675135
DNA Repair R-HSA-73894
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Disease R-HSA-1643685
Cellular responses to stimuli R-HSA-8953897
Fanconi Anemia Pathway R-HSA-6783310
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Meiotic synapsis R-HSA-1221632
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M Checkpoints R-HSA-69481
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Gene expression (Transcription) R-HSA-74160
Cell Cycle Checkpoints R-HSA-69620
G2/M DNA damage checkpoint R-HSA-69473
Processing of DNA double-strand break ends R-HSA-5693607
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
DNA Double-Strand Break Repair R-HSA-5693532
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Reproduction R-HSA-1474165
Meiosis R-HSA-1500620
Activation of ATR in response to replication stress R-HSA-176187
Homology Directed Repair R-HSA-5693538
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Cell Cycle R-HSA-1640170
DNA Repair R-HSA-73894
G2/M DNA damage checkpoint R-HSA-69473
Reproduction R-HSA-1474165
Meiosis R-HSA-1500620
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Homology Directed Repair R-HSA-5693538
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Fanconi Anemia Pathway R-HSA-6783310
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Regulation of HSF1-mediated heat shock response R-HSA-3371453
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
HDR through Homologous Recombination (HRR) R-HSA-5685942
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of TP53 Activity R-HSA-5633007
DNA Double-Strand Break Repair R-HSA-5693532
Cell Cycle Checkpoints R-HSA-69620
Disease R-HSA-1643685
Meiotic synapsis R-HSA-1221632
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M Checkpoints R-HSA-69481
Activation of ATR in response to replication stress R-HSA-176187
Diseases of DNA repair R-HSA-9675135
Cellular responses to stimuli R-HSA-8953897
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Cellular response to heat stress R-HSA-3371556
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of HSF1-mediated heat shock response R-HSA-3371453
HDR through Homologous Recombination (HRR) R-HSA-5685942
Reproduction R-HSA-1474165
Fanconi Anemia Pathway R-HSA-6783310
Homology Directed Repair R-HSA-5693538
Cellular response to heat stress R-HSA-3371556
Activation of ATR in response to replication stress R-HSA-176187
Processing of DNA double-strand break ends R-HSA-5693607
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
G2/M DNA damage checkpoint R-HSA-69473
Diseases of DNA repair R-HSA-9675135
Meiotic synapsis R-HSA-1221632
DNA Double-Strand Break Repair R-HSA-5693532
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Meiosis R-HSA-1500620
Gene expression (Transcription) R-HSA-74160
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Cell Cycle R-HSA-1640170
DNA Repair R-HSA-73894
G2/M Checkpoints R-HSA-69481
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle R-HSA-1640170
Gene expression (Transcription) R-HSA-74160
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Repair R-HSA-73894
G2/M Checkpoints R-HSA-69481
Homology Directed Repair R-HSA-5693538
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) R-HSA-5685942
Cell Cycle Checkpoints R-HSA-69620
Cellular responses to stress R-HSA-2262752
Fanconi Anemia Pathway R-HSA-6783310
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Meiosis R-HSA-1500620
DNA Double-Strand Break Repair R-HSA-5693532
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Meiotic synapsis R-HSA-1221632
Cellular responses to stimuli R-HSA-8953897
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular response to heat stress R-HSA-3371556
Reproduction R-HSA-1474165
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Impaired BRCA2 binding to RAD51 R-HSA-9709570
G2/M DNA damage checkpoint R-HSA-69473
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Diseases of DNA repair R-HSA-9675135
Activation of ATR in response to replication stress R-HSA-176187
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Cell Cycle R-HSA-1640170
G2/M Checkpoints R-HSA-69481
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Disease R-HSA-1643685
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Processing of DNA double-strand break ends R-HSA-5693607
G2/M DNA damage checkpoint R-HSA-69473
Fanconi Anemia Pathway R-HSA-6783310
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Cell Cycle Checkpoints R-HSA-69620
Transcriptional Regulation by TP53 R-HSA-3700989
Activation of ATR in response to replication stress R-HSA-176187
DNA Repair R-HSA-73894
Diseases of DNA repair R-HSA-9675135
DNA Double-Strand Break Repair R-HSA-5693532
Cellular responses to stimuli R-HSA-8953897
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of TP53 Activity R-HSA-5633007
Meiosis R-HSA-1500620
Generic Transcription Pathway R-HSA-212436
Reproduction R-HSA-1474165
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Cellular response to heat stress R-HSA-3371556
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Meiotic synapsis R-HSA-1221632
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Gene expression (Transcription) R-HSA-74160
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Activation of ATR in response to replication stress R-HSA-176187
Diseases of DNA repair R-HSA-9675135
Cell Cycle Checkpoints R-HSA-69620
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
G2/M DNA damage checkpoint R-HSA-69473
Meiosis R-HSA-1500620
HDR through Homologous Recombination (HRR) R-HSA-5685942
Cell Cycle R-HSA-1640170
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Gene expression (Transcription) R-HSA-74160
Cellular responses to stress R-HSA-2262752
Fanconi Anemia Pathway R-HSA-6783310
Cellular responses to stimuli R-HSA-8953897
Meiotic synapsis R-HSA-1221632
DNA Double-Strand Break Repair R-HSA-5693532
Homology Directed Repair R-HSA-5693538
Reproduction R-HSA-1474165
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity R-HSA-5633007
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Cellular response to heat stress R-HSA-3371556
Transcriptional Regulation by TP53 R-HSA-3700989
HDR through Single Strand Annealing (SSA) R-HSA-5685938
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Generic Transcription Pathway R-HSA-212436
Disease R-HSA-1643685
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cellular responses to stress R-HSA-2262752
Activation of ATR in response to replication stress R-HSA-176187
G2/M DNA damage checkpoint R-HSA-69473
Gene expression (Transcription) R-HSA-74160
Meiotic synapsis R-HSA-1221632
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G2/M Checkpoints R-HSA-69481
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
DNA Repair R-HSA-73894
DNA Double-Strand Break Repair R-HSA-5693532
Cellular response to heat stress R-HSA-3371556
Cell Cycle R-HSA-1640170
Cellular responses to stimuli R-HSA-8953897
Homology Directed Repair R-HSA-5693538
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle Checkpoints R-HSA-69620
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Reproduction R-HSA-1474165
Fanconi Anemia Pathway R-HSA-6783310
Generic Transcription Pathway R-HSA-212436
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Meiosis R-HSA-1500620
Diseases of DNA repair R-HSA-9675135
HDR through Homologous Recombination (HRR) R-HSA-5685942
Processing of DNA double-strand break ends R-HSA-5693607
Transcriptional Regulation by TP53 R-HSA-3700989
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cellular responses to stress R-HSA-2262752
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Regulation of TP53 Activity R-HSA-5633007
Diseases of DNA repair R-HSA-9675135
G2/M DNA damage checkpoint R-HSA-69473
Homology Directed Repair R-HSA-5693538
Processing of DNA double-strand break ends R-HSA-5693607
Fanconi Anemia Pathway R-HSA-6783310
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Double-Strand Break Repair R-HSA-5693532
Generic Transcription Pathway R-HSA-212436
Activation of ATR in response to replication stress R-HSA-176187
Regulation of HSF1-mediated heat shock response R-HSA-3371453
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Meiotic synapsis R-HSA-1221632
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
G2/M Checkpoints R-HSA-69481
Disease R-HSA-1643685
Cellular response to heat stress R-HSA-3371556
Meiosis R-HSA-1500620
Reproduction R-HSA-1474165
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) R-HSA-5685942
Cell Cycle R-HSA-1640170
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Gene expression (Transcription) R-HSA-74160
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Meiosis R-HSA-1500620
Fanconi Anemia Pathway R-HSA-6783310
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Diseases of DNA repair R-HSA-9675135
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle R-HSA-1640170
Cellular responses to stress R-HSA-2262752
Reproduction R-HSA-1474165
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Generic Transcription Pathway R-HSA-212436
G2/M DNA damage checkpoint R-HSA-69473
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HDR through Single Strand Annealing (SSA) R-HSA-5685938
DNA Repair R-HSA-73894
Meiotic synapsis R-HSA-1221632
Cellular response to heat stress R-HSA-3371556
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Cellular responses to stimuli R-HSA-8953897
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
HDR through Homologous Recombination (HRR) R-HSA-5685942
Processing of DNA double-strand break ends R-HSA-5693607
Gene expression (Transcription) R-HSA-74160
Disease R-HSA-1643685
Regulation of TP53 Activity R-HSA-5633007
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G2/M Checkpoints R-HSA-69481
DNA Double-Strand Break Repair R-HSA-5693532
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Cellular response to heat stress R-HSA-3371556
Gene expression (Transcription) R-HSA-74160
Meiotic synapsis R-HSA-1221632
Cell Cycle R-HSA-1640170
Cellular responses to stress R-HSA-2262752
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cell Cycle Checkpoints R-HSA-69620
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Diseases of DNA repair R-HSA-9675135
Cellular responses to stimuli R-HSA-8953897
Processing of DNA double-strand break ends R-HSA-5693607
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Impaired BRCA2 binding to RAD51 R-HSA-9709570
G2/M DNA damage checkpoint R-HSA-69473
DNA Repair R-HSA-73894
Disease R-HSA-1643685
Regulation of TP53 Activity R-HSA-5633007
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Activation of ATR in response to replication stress R-HSA-176187
G2/M Checkpoints R-HSA-69481
Meiosis R-HSA-1500620
Reproduction R-HSA-1474165
HDR through Homologous Recombination (HRR) R-HSA-5685942
Generic Transcription Pathway R-HSA-212436
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by TP53 R-HSA-3700989
HDR through Single Strand Annealing (SSA) R-HSA-5685938
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Homology Directed Repair R-HSA-5693538
Fanconi Anemia Pathway R-HSA-6783310
Homology Directed Repair R-HSA-5693538
Fanconi Anemia Pathway R-HSA-6783310
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Meiosis R-HSA-1500620
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Regulation of TP53 Activity R-HSA-5633007
Activation of ATR in response to replication stress R-HSA-176187
Cellular response to heat stress R-HSA-3371556
HDR through Homologous Recombination (HRR) R-HSA-5685942
Gene expression (Transcription) R-HSA-74160
Processing of DNA double-strand break ends R-HSA-5693607
Reproduction R-HSA-1474165
G2/M Checkpoints R-HSA-69481
Diseases of DNA repair R-HSA-9675135
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Meiotic synapsis R-HSA-1221632
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Disease R-HSA-1643685
Regulation of HSF1-mediated heat shock response R-HSA-3371453
DNA Double-Strand Break Repair R-HSA-5693532
Cellular responses to stress R-HSA-2262752
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989

Expression Atlas ENSG00000175054
LRG display in Ensembl gene LRG_1403
NCBI gene (formerly Entrezgene) 545
GeneCards 882
HGNC Symbol HGNC:882
MIM gene 601215
MIM morbid 614564
UniProtKB Gene Name Q13535
WikiGene 545
Gene: MTOR
Ensembl ID : ENSG00000198793
Description: mechanistic target of rapamycin kinase
Gene Synonyms: FLJ44809,FRAP,FRAP1,FRAP2,RAFT1,RAPT1
26 APIs:
224 Possible Orthologues:

Costimulation by the CD28 family R-HSA-388841
MTOR signalling R-HSA-165159
Costimulation by the CD28 family R-HSA-388841
HSF1-dependent transactivation R-HSA-3371571
Signal Transduction R-HSA-162582
Autophagy R-HSA-9612973
Cellular response to starvation R-HSA-9711097
Cellular responses to stimuli R-HSA-8953897
RNA Polymerase II Transcription R-HSA-73857
PIP3 activates AKT signaling R-HSA-1257604
Macroautophagy R-HSA-1632852
Generic Transcription Pathway R-HSA-212436
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
MTOR signalling R-HSA-165159
TP53 Regulates Metabolic Genes R-HSA-5628897
Gene expression (Transcription) R-HSA-74160
VEGFR2 mediated vascular permeability R-HSA-5218920
VEGFA-VEGFR2 Pathway R-HSA-4420097
PTEN Regulation R-HSA-6807070
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K/AKT Signaling in Cancer R-HSA-2219528
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular response to heat stress R-HSA-3371556
Regulation of TP53 Degradation R-HSA-6804757
Regulation of PTEN gene transcription R-HSA-8943724
Immune System R-HSA-168256
Regulation of TP53 Expression and Degradation R-HSA-6806003
Signaling by VEGF R-HSA-194138
Adaptive Immune System R-HSA-1280218
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cellular responses to stress R-HSA-2262752
mTORC1-mediated signalling R-HSA-166208
Amino acids regulate mTORC1 R-HSA-9639288
CD28 co-stimulation R-HSA-389356
Transcriptional Regulation by TP53 R-HSA-3700989
Disease R-HSA-1643685
Intracellular signaling by second messengers R-HSA-9006925
CD28 dependent PI3K/Akt signaling R-HSA-389357
Regulation of TP53 Activity R-HSA-5633007
Adaptive Immune System R-HSA-1280218
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
Transcriptional Regulation by TP53 R-HSA-3700989
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Regulation of TP53 Degradation R-HSA-6804757
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
MTOR signalling R-HSA-165159
Macroautophagy R-HSA-1632852
Amino acids regulate mTORC1 R-HSA-9639288
Signal Transduction R-HSA-162582
CD28 co-stimulation R-HSA-389356
VEGFR2 mediated vascular permeability R-HSA-5218920
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
HSF1-dependent transactivation R-HSA-3371571
Autophagy R-HSA-9612973
Cellular responses to stress R-HSA-2262752
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by VEGF R-HSA-194138
TP53 Regulates Metabolic Genes R-HSA-5628897
CD28 dependent PI3K/Akt signaling R-HSA-389357
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
VEGFA-VEGFR2 Pathway R-HSA-4420097
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Expression and Degradation R-HSA-6806003
Costimulation by the CD28 family R-HSA-388841
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PTEN Regulation R-HSA-6807070
mTORC1-mediated signalling R-HSA-166208
Generic Transcription Pathway R-HSA-212436
Cellular response to heat stress R-HSA-3371556
Immune System R-HSA-168256
Intracellular signaling by second messengers R-HSA-9006925
Cellular response to starvation R-HSA-9711097
Cellular response to heat stress R-HSA-3371556
CD28 dependent PI3K/Akt signaling R-HSA-389357
PIP3 activates AKT signaling R-HSA-1257604
Transcriptional Regulation by TP53 R-HSA-3700989
Autophagy R-HSA-9612973
VEGFR2 mediated vascular permeability R-HSA-5218920
Regulation of PTEN gene transcription R-HSA-8943724
Immune System R-HSA-168256
MTOR signalling R-HSA-165159
Signaling by VEGF R-HSA-194138
VEGFA-VEGFR2 Pathway R-HSA-4420097
Cellular responses to stimuli R-HSA-8953897
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
HSF1-dependent transactivation R-HSA-3371571
Cellular response to starvation R-HSA-9711097
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Regulation of TP53 Expression and Degradation R-HSA-6806003
Regulation of TP53 Activity R-HSA-5633007
TP53 Regulates Metabolic Genes R-HSA-5628897
Signal Transduction R-HSA-162582
Regulation of TP53 Degradation R-HSA-6804757
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Disease R-HSA-1643685
Costimulation by the CD28 family R-HSA-388841
Gene expression (Transcription) R-HSA-74160
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
mTORC1-mediated signalling R-HSA-166208
Amino acids regulate mTORC1 R-HSA-9639288
Adaptive Immune System R-HSA-1280218
Macroautophagy R-HSA-1632852
PTEN Regulation R-HSA-6807070
CD28 co-stimulation R-HSA-389356
Cellular responses to stress R-HSA-2262752
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RNA Polymerase II Transcription R-HSA-73857
Regulation of PTEN gene transcription R-HSA-8943724
Costimulation by the CD28 family R-HSA-388841
Intracellular signaling by second messengers R-HSA-9006925
Immune System R-HSA-168256
RNA Polymerase II Transcription R-HSA-73857
Signaling by VEGF R-HSA-194138
PIP3 activates AKT signaling R-HSA-1257604
CD28 co-stimulation R-HSA-389356
Autophagy R-HSA-9612973
Signal Transduction R-HSA-162582
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Generic Transcription Pathway R-HSA-212436
HSF1-dependent transactivation R-HSA-3371571
mTORC1-mediated signalling R-HSA-166208
Macroautophagy R-HSA-1632852
Adaptive Immune System R-HSA-1280218
Cellular response to starvation R-HSA-9711097
PTEN Regulation R-HSA-6807070
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
CD28 dependent PI3K/Akt signaling R-HSA-389357
Gene expression (Transcription) R-HSA-74160
TP53 Regulates Metabolic Genes R-HSA-5628897
VEGFR2 mediated vascular permeability R-HSA-5218920
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFA-VEGFR2 Pathway R-HSA-4420097
Regulation of TP53 Degradation R-HSA-6804757
PI3K/AKT Signaling in Cancer R-HSA-2219528
Disease R-HSA-1643685
Transcriptional Regulation by TP53 R-HSA-3700989
MTOR signalling R-HSA-165159
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Expression and Degradation R-HSA-6806003
Amino acids regulate mTORC1 R-HSA-9639288
Cellular responses to stimuli R-HSA-8953897
Cellular response to heat stress R-HSA-3371556
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Expression and Degradation R-HSA-6806003
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular responses to stimuli R-HSA-8953897
Cellular response to starvation R-HSA-9711097
Transcriptional Regulation by TP53 R-HSA-3700989
TP53 Regulates Metabolic Genes R-HSA-5628897
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
MTOR signalling R-HSA-165159
CD28 dependent PI3K/Akt signaling R-HSA-389357
PIP3 activates AKT signaling R-HSA-1257604
mTORC1-mediated signalling R-HSA-166208
VEGFA-VEGFR2 Pathway R-HSA-4420097
CD28 co-stimulation R-HSA-389356
Macroautophagy R-HSA-1632852
Autophagy R-HSA-9612973
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Regulation of TP53 Activity R-HSA-5633007
Regulation of TP53 Degradation R-HSA-6804757
HSF1-dependent transactivation R-HSA-3371571
PTEN Regulation R-HSA-6807070
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Generic Transcription Pathway R-HSA-212436
Disease R-HSA-1643685
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cellular responses to stress R-HSA-2262752
Gene expression (Transcription) R-HSA-74160
Intracellular signaling by second messengers R-HSA-9006925
Amino acids regulate mTORC1 R-HSA-9639288
Signaling by VEGF R-HSA-194138
Cellular response to heat stress R-HSA-3371556
VEGFR2 mediated vascular permeability R-HSA-5218920
Signal Transduction R-HSA-162582
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Degradation R-HSA-6804757
mTORC1-mediated signalling R-HSA-166208
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFA-VEGFR2 Pathway R-HSA-4420097
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TP53 Regulates Metabolic Genes R-HSA-5628897
MTOR signalling R-HSA-165159
CD28 co-stimulation R-HSA-389356
VEGFR2 mediated vascular permeability R-HSA-5218920
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PTEN Regulation R-HSA-6807070
Adaptive Immune System R-HSA-1280218
Regulation of TP53 Activity R-HSA-5633007
Intracellular signaling by second messengers R-HSA-9006925
Costimulation by the CD28 family R-HSA-388841
HSF1-dependent transactivation R-HSA-3371571
Amino acids regulate mTORC1 R-HSA-9639288
Transcriptional Regulation by TP53 R-HSA-3700989
PIP3 activates AKT signaling R-HSA-1257604
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Expression and Degradation R-HSA-6806003
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cellular responses to stress R-HSA-2262752
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Gene expression (Transcription) R-HSA-74160
Cellular response to starvation R-HSA-9711097
Disease R-HSA-1643685
Cellular response to heat stress R-HSA-3371556
CD28 dependent PI3K/Akt signaling R-HSA-389357
Immune System R-HSA-168256
Autophagy R-HSA-9612973
Signaling by VEGF R-HSA-194138
Macroautophagy R-HSA-1632852
VEGFA-VEGFR2 Pathway R-HSA-4420097
PIP3 activates AKT signaling R-HSA-1257604
Costimulation by the CD28 family R-HSA-388841
Intracellular signaling by second messengers R-HSA-9006925
Cellular responses to stimuli R-HSA-8953897
HSF1-dependent transactivation R-HSA-3371571
Regulation of PTEN gene transcription R-HSA-8943724
Signal Transduction R-HSA-162582
mTORC1-mediated signalling R-HSA-166208
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by VEGF R-HSA-194138
Transcriptional Regulation by TP53 R-HSA-3700989
Adaptive Immune System R-HSA-1280218
Macroautophagy R-HSA-1632852
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Cellular response to starvation R-HSA-9711097
PTEN Regulation R-HSA-6807070
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular response to heat stress R-HSA-3371556
Regulation of TP53 Degradation R-HSA-6804757
Immune System R-HSA-168256
Autophagy R-HSA-9612973
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of TP53 Activity R-HSA-5633007
CD28 co-stimulation R-HSA-389356
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
TP53 Regulates Metabolic Genes R-HSA-5628897
Amino acids regulate mTORC1 R-HSA-9639288
Regulation of TP53 Expression and Degradation R-HSA-6806003
PI3K/AKT Signaling in Cancer R-HSA-2219528
VEGFR2 mediated vascular permeability R-HSA-5218920
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stress R-HSA-2262752
HSF1-dependent transactivation R-HSA-3371571
PI3K/AKT Signaling in Cancer R-HSA-2219528
TP53 Regulates Metabolic Genes R-HSA-5628897
Cellular responses to stress R-HSA-2262752
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
PIP3 activates AKT signaling R-HSA-1257604
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
VEGFA-VEGFR2 Pathway R-HSA-4420097
Autophagy R-HSA-9612973
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity R-HSA-5633007
Regulation of PTEN gene transcription R-HSA-8943724
CD28 dependent PI3K/Akt signaling R-HSA-389357
RNA Polymerase II Transcription R-HSA-73857
Costimulation by the CD28 family R-HSA-388841
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
CD28 co-stimulation R-HSA-389356
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cellular response to starvation R-HSA-9711097
Adaptive Immune System R-HSA-1280218
Immune System R-HSA-168256
Macroautophagy R-HSA-1632852
MTOR signalling R-HSA-165159
Regulation of TP53 Expression and Degradation R-HSA-6806003
Gene expression (Transcription) R-HSA-74160
PTEN Regulation R-HSA-6807070
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Intracellular signaling by second messengers R-HSA-9006925
VEGFR2 mediated vascular permeability R-HSA-5218920
Cellular response to heat stress R-HSA-3371556
Amino acids regulate mTORC1 R-HSA-9639288
Signaling by VEGF R-HSA-194138
Regulation of TP53 Degradation R-HSA-6804757
mTORC1-mediated signalling R-HSA-166208
Cellular response to heat stress R-HSA-3371556
TP53 Regulates Metabolic Genes R-HSA-5628897
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
HSF1-dependent transactivation R-HSA-3371571
Costimulation by the CD28 family R-HSA-388841
Adaptive Immune System R-HSA-1280218
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Regulation of TP53 Degradation R-HSA-6804757
Cellular responses to stimuli R-HSA-8953897
mTORC1-mediated signalling R-HSA-166208
Signaling by VEGF R-HSA-194138
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Amino acids regulate mTORC1 R-HSA-9639288
Autophagy R-HSA-9612973
Regulation of PTEN gene transcription R-HSA-8943724
PTEN Regulation R-HSA-6807070
CD28 co-stimulation R-HSA-389356
Regulation of TP53 Expression and Degradation R-HSA-6806003
VEGFA-VEGFR2 Pathway R-HSA-4420097
Cellular responses to stress R-HSA-2262752
Signal Transduction R-HSA-162582
Macroautophagy R-HSA-1632852
MTOR signalling R-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
VEGFR2 mediated vascular permeability R-HSA-5218920
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
PIP3 activates AKT signaling R-HSA-1257604
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cellular response to starvation R-HSA-9711097
Regulation of TP53 Activity R-HSA-5633007
Immune System R-HSA-168256
Transcriptional Regulation by TP53 R-HSA-3700989
VEGFA-VEGFR2 Pathway R-HSA-4420097
Adaptive Immune System R-HSA-1280218
HSF1-dependent transactivation R-HSA-3371571
Immune System R-HSA-168256
RNA Polymerase II Transcription R-HSA-73857
Regulation of TP53 Activity R-HSA-5633007
Costimulation by the CD28 family R-HSA-388841
PTEN Regulation R-HSA-6807070
CD28 co-stimulation R-HSA-389356
Intracellular signaling by second messengers R-HSA-9006925
Cellular responses to stimuli R-HSA-8953897
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Gene expression (Transcription) R-HSA-74160
VEGFR2 mediated vascular permeability R-HSA-5218920
Cellular responses to stress R-HSA-2262752
Regulation of PTEN gene transcription R-HSA-8943724
Regulation of TP53 Degradation R-HSA-6804757
MTOR signalling R-HSA-165159
Signaling by VEGF R-HSA-194138
Macroautophagy R-HSA-1632852
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Expression and Degradation R-HSA-6806003
CD28 dependent PI3K/Akt signaling R-HSA-389357
Cellular response to heat stress R-HSA-3371556
Amino acids regulate mTORC1 R-HSA-9639288
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
Autophagy R-HSA-9612973
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
mTORC1-mediated signalling R-HSA-166208
Signal Transduction R-HSA-162582
Cellular response to starvation R-HSA-9711097
TP53 Regulates Metabolic Genes R-HSA-5628897
PI3K/AKT Signaling in Cancer R-HSA-2219528
Regulation of TP53 Activity R-HSA-5633007
RNA Polymerase II Transcription R-HSA-73857
Autophagy R-HSA-9612973
HSF1-dependent transactivation R-HSA-3371571
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cellular responses to stress R-HSA-2262752
CD28 dependent PI3K/Akt signaling R-HSA-389357
PI3K/AKT Signaling in Cancer R-HSA-2219528
Gene expression (Transcription) R-HSA-74160
Disease R-HSA-1643685
VEGFA-VEGFR2 Pathway R-HSA-4420097
Regulation of TP53 Degradation R-HSA-6804757
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cellular response to starvation R-HSA-9711097
Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400
Cellular responses to stimuli R-HSA-8953897
Signaling by VEGF R-HSA-194138
Adaptive Immune System R-HSA-1280218
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
Regulation of PTEN gene transcription R-HSA-8943724
PIP3 activates AKT signaling R-HSA-1257604
Transcriptional Regulation by TP53 R-HSA-3700989
Cellular response to heat stress R-HSA-3371556
TP53 Regulates Metabolic Genes R-HSA-5628897
VEGFR2 mediated vascular permeability R-HSA-5218920
Generic Transcription Pathway R-HSA-212436
MTOR signalling R-HSA-165159
CD28 co-stimulation R-HSA-389356
mTORC1-mediated signalling R-HSA-166208
Costimulation by the CD28 family R-HSA-388841
Immune System R-HSA-168256
Macroautophagy R-HSA-1632852
Amino acids regulate mTORC1 R-HSA-9639288
Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-380972
PTEN Regulation R-HSA-6807070

Expression Atlas ENSG00000198793
LRG display in Ensembl gene LRG_734
NCBI gene (formerly Entrezgene) 2475
GeneCards 3942
HGNC Symbol HGNC:3942
MIM gene 601231
MIM morbid 616638
UniProtKB Gene Name P42345
WikiGene 2475
Gene: BCR
Ensembl ID : ENSG00000186716
Description: BCR activator of RhoGEF and GTPase
Gene Synonyms: ALL,BCR1,CML,D22S11,D22S662,PHL
8 APIs:
285 Possible Orthologues:

Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOC GTPase cycle R-HSA-9013106
RAC1 GTPase cycle R-HSA-9013149
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RHOA GTPase cycle R-HSA-8980692
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
FGFR1 mutant receptor activation R-HSA-1839124
RAC2 GTPase cycle R-HSA-9013404
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
RHOB GTPase cycle R-HSA-9013026
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOA GTPase cycle R-HSA-8980692
Signaling by Rho GTPases R-HSA-194315
RHOC GTPase cycle R-HSA-9013106
RHOB GTPase cycle R-HSA-9013026
CDC42 GTPase cycle R-HSA-9013148
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
FGFR1 mutant receptor activation R-HSA-1839124
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR1 in disease R-HSA-5655302
RHO GTPase cycle R-HSA-9012999
RAC2 GTPase cycle R-HSA-9013404
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOB GTPase cycle R-HSA-9013026
RAC2 GTPase cycle R-HSA-9013404
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR in disease R-HSA-1226099
RHOA GTPase cycle R-HSA-8980692
RHOC GTPase cycle R-HSA-9013106
CDC42 GTPase cycle R-HSA-9013148
RAC1 GTPase cycle R-HSA-9013149
Signaling by Rho GTPases R-HSA-194315
RAC3 GTPase cycle R-HSA-9013423
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR1 in disease R-HSA-5655302
RAC3 GTPase cycle R-HSA-9013423
RHOB GTPase cycle R-HSA-9013026
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
CDC42 GTPase cycle R-HSA-9013148
RHOA GTPase cycle R-HSA-8980692
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by FGFR1 in disease R-HSA-5655302
Signal Transduction R-HSA-162582
RAC1 GTPase cycle R-HSA-9013149
RHOC GTPase cycle R-HSA-9013106
RAC2 GTPase cycle R-HSA-9013404
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
RAC2 GTPase cycle R-HSA-9013404
RHOA GTPase cycle R-HSA-8980692
Signal Transduction R-HSA-162582
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
RHOC GTPase cycle R-HSA-9013106
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
RAC1 GTPase cycle R-HSA-9013149
FGFR1 mutant receptor activation R-HSA-1839124
RAC3 GTPase cycle R-HSA-9013423
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by Rho GTPases R-HSA-194315
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
CDC42 GTPase cycle R-HSA-9013148
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOA GTPase cycle R-HSA-8980692
RHOB GTPase cycle R-HSA-9013026
RHOC GTPase cycle R-HSA-9013106
RAC2 GTPase cycle R-HSA-9013404
Disease R-HSA-1643685
RAC1 GTPase cycle R-HSA-9013149
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases R-HSA-194315
RHOA GTPase cycle R-HSA-8980692
RHOC GTPase cycle R-HSA-9013106
Signaling by FGFR1 in disease R-HSA-5655302
RHOB GTPase cycle R-HSA-9013026
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
RAC2 GTPase cycle R-HSA-9013404
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
FGFR1 mutant receptor activation R-HSA-1839124
RHOA GTPase cycle R-HSA-8980692
RHO GTPase cycle R-HSA-9012999
Signal Transduction R-HSA-162582
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC3 GTPase cycle R-HSA-9013423
CDC42 GTPase cycle R-HSA-9013148
RHOC GTPase cycle R-HSA-9013106
Signaling by FGFR in disease R-HSA-1226099
RAC2 GTPase cycle R-HSA-9013404
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
Signaling by Rho GTPases R-HSA-194315
CDC42 GTPase cycle R-HSA-9013148
Disease R-HSA-1643685
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC1 GTPase cycle R-HSA-9013149
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
RHOC GTPase cycle R-HSA-9013106
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR1 in disease R-HSA-5655302
RAC2 GTPase cycle R-HSA-9013404
RHOA GTPase cycle R-HSA-8980692
RAC3 GTPase cycle R-HSA-9013423
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RAC2 GTPase cycle R-HSA-9013404
RHOC GTPase cycle R-HSA-9013106
RHOA GTPase cycle R-HSA-8980692
Signaling by FGFR1 in disease R-HSA-5655302
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
FGFR1 mutant receptor activation R-HSA-1839124
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOB GTPase cycle R-HSA-9013026
RAC1 GTPase cycle R-HSA-9013149
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHO GTPase cycle R-HSA-9012999
RHO GTPase cycle R-HSA-9012999
RHOC GTPase cycle R-HSA-9013106
FGFR1 mutant receptor activation R-HSA-1839124
RAC2 GTPase cycle R-HSA-9013404
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR in disease R-HSA-1226099
Signal Transduction R-HSA-162582
RHOB GTPase cycle R-HSA-9013026
Disease R-HSA-1643685
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOA GTPase cycle R-HSA-8980692

Expression Atlas ENSG00000186716
LRG display in Ensembl gene LRG_1112
NCBI gene (formerly Entrezgene) 613
GeneCards 1014
HGNC Symbol HGNC:1014
MIM gene 151410
MIM morbid 613065
UniProtKB Gene Name P11274
WikiGene 613