Gene: PRKD1
Ensembl ID : ENSG00000184304
Description: protein kinase D1
Gene Synonyms: PKC-MU,PKCM,PKD,PRKCM
5 APIs:
214 Possible Orthologues:

Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157

Expression Atlas ENSG00000184304
NCBI gene (formerly Entrezgene) 5587
GeneCards 9407
HGNC Symbol HGNC:9407
MIM gene 605435
MIM morbid 617364
UniProtKB Gene Name Q15139
WikiGene 5587
Gene: FGFR1
Ensembl ID : ENSG00000077782
Description: fibroblast growth factor receptor 1
Gene Synonyms: BFGFR,CD331,CEK,FLG,FLT2,H2,H3,H4,H5,KAL2,N-SAM
26 APIs:
293 Possible Orthologues:

MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by activated point mutants of FGFR1 R-HSA-1839122
MAPK family signaling cascades R-HSA-5683057
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR1 in disease R-HSA-5655302
Downstream signaling of activated FGFR1 R-HSA-5654687
RAF/MAP kinase cascade R-HSA-5673001
Gastrulation R-HSA-9758941
Signal Transduction R-HSA-162582
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
FGFR1 ligand binding and activation R-HSA-190242
Developmental Biology R-HSA-1266738
MAPK1/MAPK3 signaling R-HSA-5684996
PI3K Cascade R-HSA-109704
Signaling by FGFR in disease R-HSA-1226099
FGFR1c and Klotho ligand binding and activation R-HSA-190374
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Negative regulation of the PI3K/AKT network R-HSA-199418
IGF1R signaling cascade R-HSA-2428924
Intracellular signaling by second messengers R-HSA-9006925
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR1 R-HSA-5654736
L1CAM interactions R-HSA-373760
Signaling by FGFR R-HSA-190236
Formation of paraxial mesoderm R-HSA-9793380
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FRS-mediated FGFR1 signaling R-HSA-5654693
Axon guidance R-HSA-422475
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI-3K cascade:FGFR1 R-HSA-5654689
FGFR1b ligand binding and activation R-HSA-190370
Disease R-HSA-1643685
FGFR1c ligand binding and activation R-HSA-190373
Signal transduction by L1 R-HSA-445144
IRS-mediated signalling R-HSA-112399
Signaling by FGFR1 amplification mutants R-HSA-1839120
Signaling by Insulin receptor R-HSA-74752
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
Negative regulation of FGFR1 signaling R-HSA-5654726
PI3K/AKT Signaling in Cancer R-HSA-2219528
FGFR1 mutant receptor activation R-HSA-1839124
Nervous system development R-HSA-9675108
PIP3 activates AKT signaling R-HSA-1257604
SHC-mediated cascade:FGFR1 R-HSA-5654688
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IGF1R signaling cascade R-HSA-2428924
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
PI3K/AKT Signaling in Cancer R-HSA-2219528
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by FGFR1 in disease R-HSA-5655302
NCAM signaling for neurite out-growth R-HSA-375165
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR1 R-HSA-5654736
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FGFR R-HSA-190236
L1CAM interactions R-HSA-373760
Signal Transduction R-HSA-162582
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Negative regulation of FGFR1 signaling R-HSA-5654726
FGFR1 mutant receptor activation R-HSA-1839124
Axon guidance R-HSA-422475
MAPK1/MAPK3 signaling R-HSA-5684996
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
IRS-mediated signalling R-HSA-112399
Signaling by FGFR in disease R-HSA-1226099
FGFR1c and Klotho ligand binding and activation R-HSA-190374
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Insulin receptor R-HSA-74752
Signal transduction by L1 R-HSA-445144
PI-3K cascade:FGFR1 R-HSA-5654689
PI3K Cascade R-HSA-109704
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor signalling cascade R-HSA-74751
SHC-mediated cascade:FGFR1 R-HSA-5654688
MAPK family signaling cascades R-HSA-5683057
FGFR1b ligand binding and activation R-HSA-190370
FGFR1 ligand binding and activation R-HSA-190242
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Developmental Biology R-HSA-1266738
Signaling by FGFR1 amplification mutants R-HSA-1839120
Gastrulation R-HSA-9758941
FGFR1c ligand binding and activation R-HSA-190373
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by activated point mutants of FGFR1 R-HSA-1839122
Formation of paraxial mesoderm R-HSA-9793380
PIP3 activates AKT signaling R-HSA-1257604
Nervous system development R-HSA-9675108
Signaling by FGFR1 amplification mutants R-HSA-1839120
Formation of paraxial mesoderm R-HSA-9793380
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by Insulin receptor R-HSA-74752
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
RAF/MAP kinase cascade R-HSA-5673001
Gastrulation R-HSA-9758941
PI-3K cascade:FGFR1 R-HSA-5654689
Downstream signaling of activated FGFR1 R-HSA-5654687
SHC-mediated cascade:FGFR1 R-HSA-5654688
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by activated point mutants of FGFR1 R-HSA-1839122
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PI3K Cascade R-HSA-109704
PIP3 activates AKT signaling R-HSA-1257604
FGFR1c ligand binding and activation R-HSA-190373
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
L1CAM interactions R-HSA-373760
MAPK1/MAPK3 signaling R-HSA-5684996
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by FGFR1 R-HSA-5654736
FGFR1c and Klotho ligand binding and activation R-HSA-190374
Insulin receptor signalling cascade R-HSA-74751
FGFR1 ligand binding and activation R-HSA-190242
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR in disease R-HSA-1226099
IRS-related events triggered by IGF1R R-HSA-2428928
Signal transduction by L1 R-HSA-445144
Axon guidance R-HSA-422475
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Intracellular signaling by second messengers R-HSA-9006925
IRS-mediated signalling R-HSA-112399
Nervous system development R-HSA-9675108
IGF1R signaling cascade R-HSA-2428924
FRS-mediated FGFR1 signaling R-HSA-5654693
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Signaling by FGFR R-HSA-190236
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
FGFR1b ligand binding and activation R-HSA-190370
Developmental Biology R-HSA-1266738
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR R-HSA-190236
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
FRS-mediated FGFR1 signaling R-HSA-5654693
Downstream signaling of activated FGFR1 R-HSA-5654687
IRS-mediated signalling R-HSA-112399
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR1c and Klotho ligand binding and activation R-HSA-190374
Signaling by Insulin receptor R-HSA-74752
PI3K Cascade R-HSA-109704
Nervous system development R-HSA-9675108
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
Signal transduction by L1 R-HSA-445144
Gastrulation R-HSA-9758941
Signal Transduction R-HSA-162582
FGFR1b ligand binding and activation R-HSA-190370
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Disease R-HSA-1643685
RAF/MAP kinase cascade R-HSA-5673001
Intracellular signaling by second messengers R-HSA-9006925
Formation of paraxial mesoderm R-HSA-9793380
L1CAM interactions R-HSA-373760
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IGF1R signaling cascade R-HSA-2428924
Signaling by activated point mutants of FGFR1 R-HSA-1839122
IRS-related events triggered by IGF1R R-HSA-2428928
Axon guidance R-HSA-422475
Signaling by FGFR1 amplification mutants R-HSA-1839120
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by FGFR1 R-HSA-5654736
Insulin receptor signalling cascade R-HSA-74751
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Signaling by FGFR in disease R-HSA-1226099
FGFR1c ligand binding and activation R-HSA-190373
NCAM signaling for neurite out-growth R-HSA-375165
MAPK1/MAPK3 signaling R-HSA-5684996
FGFR1 ligand binding and activation R-HSA-190242
Negative regulation of the PI3K/AKT network R-HSA-199418
Developmental Biology R-HSA-1266738
MAPK family signaling cascades R-HSA-5683057
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
SHC-mediated cascade:FGFR1 R-HSA-5654688
FGFR1 mutant receptor activation R-HSA-1839124
Negative regulation of the PI3K/AKT network R-HSA-199418
Nervous system development R-HSA-9675108
FGFR1b ligand binding and activation R-HSA-190370
L1CAM interactions R-HSA-373760
Formation of paraxial mesoderm R-HSA-9793380
Signaling by activated point mutants of FGFR1 R-HSA-1839122
Signaling by FGFR1 R-HSA-5654736
PIP3 activates AKT signaling R-HSA-1257604
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
IGF1R signaling cascade R-HSA-2428924
Intracellular signaling by second messengers R-HSA-9006925
SHC-mediated cascade:FGFR1 R-HSA-5654688
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
FGFR1c ligand binding and activation R-HSA-190373
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signal transduction by L1 R-HSA-445144
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
IRS-mediated signalling R-HSA-112399
Signaling by FGFR1 in disease R-HSA-5655302
Negative regulation of FGFR1 signaling R-HSA-5654726
Signal Transduction R-HSA-162582
Gastrulation R-HSA-9758941
PI3K Cascade R-HSA-109704
Signaling by FGFR1 amplification mutants R-HSA-1839120
Developmental Biology R-HSA-1266738
Signaling by FGFR R-HSA-190236
IRS-related events triggered by IGF1R R-HSA-2428928
FRS-mediated FGFR1 signaling R-HSA-5654693
Disease R-HSA-1643685
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Insulin receptor R-HSA-74752
FGFR1 ligand binding and activation R-HSA-190242
MAPK family signaling cascades R-HSA-5683057
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
Axon guidance R-HSA-422475
PI3K/AKT Signaling in Cancer R-HSA-2219528
Insulin receptor signalling cascade R-HSA-74751
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI-3K cascade:FGFR1 R-HSA-5654689
NCAM signaling for neurite out-growth R-HSA-375165
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Signaling by FGFR in disease R-HSA-1226099
FGFR1c and Klotho ligand binding and activation R-HSA-190374
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
FGFR1 mutant receptor activation R-HSA-1839124
NCAM signaling for neurite out-growth R-HSA-375165
PIP3 activates AKT signaling R-HSA-1257604
Formation of paraxial mesoderm R-HSA-9793380
MAPK1/MAPK3 signaling R-HSA-5684996
Axon guidance R-HSA-422475
FGFR1c ligand binding and activation R-HSA-190373
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR R-HSA-190236
Intracellular signaling by second messengers R-HSA-9006925
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Disease R-HSA-1643685
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FGFR in disease R-HSA-1226099
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
Insulin receptor signalling cascade R-HSA-74751
FGFR1 ligand binding and activation R-HSA-190242
Signal transduction by L1 R-HSA-445144
PI3K Cascade R-HSA-109704
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
RAF/MAP kinase cascade R-HSA-5673001
FGFR1b ligand binding and activation R-HSA-190370
Signaling by Insulin receptor R-HSA-74752
Signaling by FGFR1 amplification mutants R-HSA-1839120
Signaling by activated point mutants of FGFR1 R-HSA-1839122
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Gastrulation R-HSA-9758941
Nervous system development R-HSA-9675108
SHC-mediated cascade:FGFR1 R-HSA-5654688
Developmental Biology R-HSA-1266738
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR1 signaling R-HSA-5654726
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
L1CAM interactions R-HSA-373760
Downstream signaling of activated FGFR1 R-HSA-5654687
IRS-related events triggered by IGF1R R-HSA-2428928
IGF1R signaling cascade R-HSA-2428924
Signaling by FGFR1 in disease R-HSA-5655302
IRS-mediated signalling R-HSA-112399
PI-3K cascade:FGFR1 R-HSA-5654689
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR1c and Klotho ligand binding and activation R-HSA-190374
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
FGFR1 mutant receptor activation R-HSA-1839124
Formation of paraxial mesoderm R-HSA-9793380
Signaling by FGFR1 R-HSA-5654736
MAPK family signaling cascades R-HSA-5683057
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by FGFR1 in disease R-HSA-5655302
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IGF1R signaling cascade R-HSA-2428924
Disease R-HSA-1643685
Signaling by FGFR in disease R-HSA-1226099
Insulin receptor signalling cascade R-HSA-74751
FGFR1c and Klotho ligand binding and activation R-HSA-190374
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Insulin receptor R-HSA-74752
Signaling by activated point mutants of FGFR1 R-HSA-1839122
PIP3 activates AKT signaling R-HSA-1257604
FRS-mediated FGFR1 signaling R-HSA-5654693
Intracellular signaling by second messengers R-HSA-9006925
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
SHC-mediated cascade:FGFR1 R-HSA-5654688
Axon guidance R-HSA-422475
IRS-mediated signalling R-HSA-112399
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
FGFR1c ligand binding and activation R-HSA-190373
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
L1CAM interactions R-HSA-373760
Signal transduction by L1 R-HSA-445144
PI3K Cascade R-HSA-109704
PI3K/AKT Signaling in Cancer R-HSA-2219528
Downstream signaling of activated FGFR1 R-HSA-5654687
PI-3K cascade:FGFR1 R-HSA-5654689
FGFR1 ligand binding and activation R-HSA-190242
Signaling by FGFR1 amplification mutants R-HSA-1839120
Negative regulation of FGFR1 signaling R-HSA-5654726
Developmental Biology R-HSA-1266738
FGFR1b ligand binding and activation R-HSA-190370
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR R-HSA-190236
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Negative regulation of the PI3K/AKT network R-HSA-199418
Gastrulation R-HSA-9758941
IRS-related events triggered by IGF1R R-HSA-2428928
FGFR1c ligand binding and activation R-HSA-190373
Disease R-HSA-1643685
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
RAF/MAP kinase cascade R-HSA-5673001
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
SHC-mediated cascade:FGFR1 R-HSA-5654688
Nervous system development R-HSA-9675108
PIP3 activates AKT signaling R-HSA-1257604
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR in disease R-HSA-1226099
Negative regulation of FGFR1 signaling R-HSA-5654726
Developmental Biology R-HSA-1266738
Signaling by Insulin receptor R-HSA-74752
Signaling by FGFR1 in disease R-HSA-5655302
PI3K/AKT Signaling in Cancer R-HSA-2219528
FGFR1b ligand binding and activation R-HSA-190370
IGF1R signaling cascade R-HSA-2428924
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
FGFR1 ligand binding and activation R-HSA-190242
Insulin receptor signalling cascade R-HSA-74751
Negative regulation of the PI3K/AKT network R-HSA-199418
NCAM signaling for neurite out-growth R-HSA-375165
PI-3K cascade:FGFR1 R-HSA-5654689
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Gastrulation R-HSA-9758941
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by activated point mutants of FGFR1 R-HSA-1839122
Signal transduction by L1 R-HSA-445144
L1CAM interactions R-HSA-373760
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
FRS-mediated FGFR1 signaling R-HSA-5654693
FGFR1 mutant receptor activation R-HSA-1839124
Formation of paraxial mesoderm R-HSA-9793380
Signaling by FGFR R-HSA-190236
FGFR1c and Klotho ligand binding and activation R-HSA-190374
PI3K Cascade R-HSA-109704
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR1 amplification mutants R-HSA-1839120
Intracellular signaling by second messengers R-HSA-9006925
Signaling by FGFR1 R-HSA-5654736
MAPK1/MAPK3 signaling R-HSA-5684996
Downstream signaling of activated FGFR1 R-HSA-5654687
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
FGFR1c ligand binding and activation R-HSA-190373
IGF1R signaling cascade R-HSA-2428924
Nervous system development R-HSA-9675108
FGFR1 ligand binding and activation R-HSA-190242
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FGFR R-HSA-190236
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Insulin receptor signalling cascade R-HSA-74751
L1CAM interactions R-HSA-373760
Intracellular signaling by second messengers R-HSA-9006925
Signaling by activated point mutants of FGFR1 R-HSA-1839122
PIP3 activates AKT signaling R-HSA-1257604
Signaling by FGFR1 in disease R-HSA-5655302
Signal transduction by L1 R-HSA-445144
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
Signaling by FGFR1 R-HSA-5654736
IRS-mediated signalling R-HSA-112399
Signaling by FGFR in disease R-HSA-1226099
NCAM signaling for neurite out-growth R-HSA-375165
IRS-related events triggered by IGF1R R-HSA-2428928
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K/AKT Signaling in Cancer R-HSA-2219528
Developmental Biology R-HSA-1266738
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR1 amplification mutants R-HSA-1839120
Axon guidance R-HSA-422475
FGFR1c and Klotho ligand binding and activation R-HSA-190374
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Insulin receptor R-HSA-74752
Formation of paraxial mesoderm R-HSA-9793380
SHC-mediated cascade:FGFR1 R-HSA-5654688
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K Cascade R-HSA-109704
FRS-mediated FGFR1 signaling R-HSA-5654693
MAPK family signaling cascades R-HSA-5683057
Gastrulation R-HSA-9758941
RAF/MAP kinase cascade R-HSA-5673001
FGFR1b ligand binding and activation R-HSA-190370
Developmental Biology R-HSA-1266738
Intracellular signaling by second messengers R-HSA-9006925
Signaling by FGFR R-HSA-190236
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR1 mutant receptor activation R-HSA-1839124
Signal Transduction R-HSA-162582
IRS-related events triggered by IGF1R R-HSA-2428928
Formation of paraxial mesoderm R-HSA-9793380
PI3K Cascade R-HSA-109704
Disease R-HSA-1643685
L1CAM interactions R-HSA-373760
Signal transduction by L1 R-HSA-445144
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by FGFR1 in disease R-HSA-5655302
MAPK family signaling cascades R-HSA-5683057
IRS-mediated signalling R-HSA-112399
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by activated point mutants of FGFR1 R-HSA-1839122
Epithelial-Mesenchymal Transition (EMT) during gastrulation R-HSA-9758919
Signaling by FGFR1 R-HSA-5654736
Signaling by FGFR1 amplification mutants R-HSA-1839120
FGFR1c and Klotho ligand binding and activation R-HSA-190374
Signaling by Insulin receptor R-HSA-74752
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by plasma membrane FGFR1 fusions R-HSA-8853336
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF/MAP kinase cascade R-HSA-5673001
SHC-mediated cascade:FGFR1 R-HSA-5654688
Axon guidance R-HSA-422475
IGF1R signaling cascade R-HSA-2428924
MAPK1/MAPK3 signaling R-HSA-5684996
Nervous system development R-HSA-9675108
Downstream signaling of activated FGFR1 R-HSA-5654687
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Gastrulation R-HSA-9758941
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
NCAM signaling for neurite out-growth R-HSA-375165
Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219
Insulin receptor signalling cascade R-HSA-74751
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
FGFR1b ligand binding and activation R-HSA-190370
FGFR1 ligand binding and activation R-HSA-190242
FGFR1c ligand binding and activation R-HSA-190373
Signaling by FGFR in disease R-HSA-1226099
FRS-mediated FGFR1 signaling R-HSA-5654693

Expression Atlas ENSG00000077782
LRG display in Ensembl gene LRG_993
NCBI gene (formerly Entrezgene) 2260
GeneCards 3688
HGNC Symbol HGNC:3688
MIM gene 136350
MIM morbid 615465
UniProtKB Gene Name P11362
WikiGene 2260
Gene: EML4
Ensembl ID : ENSG00000143924
Description: EMAP like 4
Gene Synonyms: C2ORF2,ELP120,ROPP120
5 APIs:
214 Possible Orthologues:

ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK in cancer R-HSA-9700206
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
M Phase R-HSA-68886
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Mitotic Prometaphase R-HSA-68877
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
ALK mutants bind TKIs R-HSA-9700645
Disease R-HSA-1643685
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK fusions and activated point mutants R-HSA-9725370
M Phase R-HSA-68886
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
ALK mutants bind TKIs R-HSA-9700645
Cell Cycle R-HSA-1640170
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
M Phase R-HSA-68886
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Cell Cycle, Mitotic R-HSA-69278
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
M Phase R-HSA-68886
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK fusions and activated point mutants R-HSA-9725370
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Mitotic Prometaphase R-HSA-68877
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
M Phase R-HSA-68886
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK in cancer R-HSA-9700206
M Phase R-HSA-68886
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
M Phase R-HSA-68886
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle, Mitotic R-HSA-69278
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
M Phase R-HSA-68886
Cell Cycle, Mitotic R-HSA-69278
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
M Phase R-HSA-68886
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Mitotic Prometaphase R-HSA-68877
Cell Cycle, Mitotic R-HSA-69278
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Disease R-HSA-1643685
ALK mutants bind TKIs R-HSA-9700645
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by ALK in cancer R-HSA-9700206
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle, Mitotic R-HSA-69278
Signaling by ALK in cancer R-HSA-9700206
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Disease R-HSA-1643685
Mitotic Prometaphase R-HSA-68877
ALK mutants bind TKIs R-HSA-9700645
Cell Cycle R-HSA-1640170
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
M Phase R-HSA-68886

Expression Atlas ENSG00000143924
NCBI gene (formerly Entrezgene) 27436
GeneCards 1316
HGNC Symbol HGNC:1316
MIM gene 607442
UniProtKB Gene Name Q9HC35
WikiGene 27436
Gene: FLT4
Ensembl ID : ENSG00000037280
Description: fms related receptor tyrosine kinase 4
Gene Synonyms: PCL,VEGFR-3,VEGFR3
46 APIs:
198 Possible Orthologues:

Signaling by VEGF R-HSA-194138
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by NOTCH R-HSA-157118
Signal Transduction R-HSA-162582
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH4 R-HSA-9013694
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by NOTCH4 R-HSA-9013694
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH R-HSA-157118
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by VEGF R-HSA-194138
Signaling by NOTCH R-HSA-157118
Signaling by VEGF R-HSA-194138
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF ligand-receptor interactions R-HSA-194313
Signal Transduction R-HSA-162582
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by NOTCH4 R-HSA-9013694
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by VEGF R-HSA-194138
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH R-HSA-157118
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH4 R-HSA-9013694
Signaling by VEGF R-HSA-194138
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by NOTCH R-HSA-157118
Signaling by VEGF R-HSA-194138
Signal Transduction R-HSA-162582
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by NOTCH4 R-HSA-9013694
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH4 R-HSA-9013694
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by NOTCH R-HSA-157118
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF ligand-receptor interactions R-HSA-194313
Signal Transduction R-HSA-162582
Signaling by VEGF R-HSA-194138
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH4 R-HSA-9013694
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by VEGF R-HSA-194138
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by VEGF R-HSA-194138
VEGF ligand-receptor interactions R-HSA-194313
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Signaling by NOTCH R-HSA-157118
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by NOTCH4 R-HSA-9013694
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
NOTCH4 Intracellular Domain Regulates Transcription R-HSA-9013695
Signaling by VEGF R-HSA-194138
Signaling by NOTCH R-HSA-157118
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF ligand-receptor interactions R-HSA-194313
Signaling by NOTCH4 R-HSA-9013694

Expression Atlas ENSG00000037280
NCBI gene (formerly Entrezgene) 2324
GeneCards 3767
HGNC Symbol HGNC:3767
MIM gene 136352
MIM morbid 618780
UniProtKB Gene Name P35916
WikiGene 2324
Gene: ATR
Ensembl ID : ENSG00000175054
Description: ATR serine/threonine kinase
Gene Synonyms: FRP1,MEC1,SCKL,SCKL1
4 APIs:
207 Possible Orthologues:

Disease R-HSA-1643685
Cell Cycle Checkpoints R-HSA-69620
Cellular response to heat stress R-HSA-3371556
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by TP53 R-HSA-3700989
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Diseases of DNA repair R-HSA-9675135
DNA Repair R-HSA-73894
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Disease R-HSA-1643685
Cellular responses to stimuli R-HSA-8953897
Fanconi Anemia Pathway R-HSA-6783310
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Meiotic synapsis R-HSA-1221632
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M Checkpoints R-HSA-69481
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Gene expression (Transcription) R-HSA-74160
Cell Cycle Checkpoints R-HSA-69620
G2/M DNA damage checkpoint R-HSA-69473
Processing of DNA double-strand break ends R-HSA-5693607
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
DNA Double-Strand Break Repair R-HSA-5693532
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Reproduction R-HSA-1474165
Meiosis R-HSA-1500620
Activation of ATR in response to replication stress R-HSA-176187
Homology Directed Repair R-HSA-5693538
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Cell Cycle R-HSA-1640170
DNA Repair R-HSA-73894
G2/M DNA damage checkpoint R-HSA-69473
Reproduction R-HSA-1474165
Meiosis R-HSA-1500620
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Homology Directed Repair R-HSA-5693538
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Fanconi Anemia Pathway R-HSA-6783310
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Regulation of HSF1-mediated heat shock response R-HSA-3371453
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
HDR through Homologous Recombination (HRR) R-HSA-5685942
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of TP53 Activity R-HSA-5633007
DNA Double-Strand Break Repair R-HSA-5693532
Cell Cycle Checkpoints R-HSA-69620
Disease R-HSA-1643685
Meiotic synapsis R-HSA-1221632
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M Checkpoints R-HSA-69481
Activation of ATR in response to replication stress R-HSA-176187
Diseases of DNA repair R-HSA-9675135
Cellular responses to stimuli R-HSA-8953897
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Cellular response to heat stress R-HSA-3371556
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of HSF1-mediated heat shock response R-HSA-3371453
HDR through Homologous Recombination (HRR) R-HSA-5685942
Reproduction R-HSA-1474165
Fanconi Anemia Pathway R-HSA-6783310
Homology Directed Repair R-HSA-5693538
Cellular response to heat stress R-HSA-3371556
Activation of ATR in response to replication stress R-HSA-176187
Processing of DNA double-strand break ends R-HSA-5693607
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
G2/M DNA damage checkpoint R-HSA-69473
Diseases of DNA repair R-HSA-9675135
Meiotic synapsis R-HSA-1221632
DNA Double-Strand Break Repair R-HSA-5693532
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Meiosis R-HSA-1500620
Gene expression (Transcription) R-HSA-74160
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Cell Cycle R-HSA-1640170
DNA Repair R-HSA-73894
G2/M Checkpoints R-HSA-69481
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle R-HSA-1640170
Gene expression (Transcription) R-HSA-74160
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Repair R-HSA-73894
G2/M Checkpoints R-HSA-69481
Homology Directed Repair R-HSA-5693538
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) R-HSA-5685942
Cell Cycle Checkpoints R-HSA-69620
Cellular responses to stress R-HSA-2262752
Fanconi Anemia Pathway R-HSA-6783310
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Meiosis R-HSA-1500620
DNA Double-Strand Break Repair R-HSA-5693532
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Meiotic synapsis R-HSA-1221632
Cellular responses to stimuli R-HSA-8953897
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular response to heat stress R-HSA-3371556
Reproduction R-HSA-1474165
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Impaired BRCA2 binding to RAD51 R-HSA-9709570
G2/M DNA damage checkpoint R-HSA-69473
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Diseases of DNA repair R-HSA-9675135
Activation of ATR in response to replication stress R-HSA-176187
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Regulation of TP53 Activity R-HSA-5633007
Cellular responses to stress R-HSA-2262752
Cell Cycle R-HSA-1640170
G2/M Checkpoints R-HSA-69481
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Disease R-HSA-1643685
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Processing of DNA double-strand break ends R-HSA-5693607
G2/M DNA damage checkpoint R-HSA-69473
Fanconi Anemia Pathway R-HSA-6783310
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Cell Cycle Checkpoints R-HSA-69620
Transcriptional Regulation by TP53 R-HSA-3700989
Activation of ATR in response to replication stress R-HSA-176187
DNA Repair R-HSA-73894
Diseases of DNA repair R-HSA-9675135
DNA Double-Strand Break Repair R-HSA-5693532
Cellular responses to stimuli R-HSA-8953897
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of TP53 Activity R-HSA-5633007
Meiosis R-HSA-1500620
Generic Transcription Pathway R-HSA-212436
Reproduction R-HSA-1474165
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Cellular response to heat stress R-HSA-3371556
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Meiotic synapsis R-HSA-1221632
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Gene expression (Transcription) R-HSA-74160
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Activation of ATR in response to replication stress R-HSA-176187
Diseases of DNA repair R-HSA-9675135
Cell Cycle Checkpoints R-HSA-69620
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
G2/M DNA damage checkpoint R-HSA-69473
Meiosis R-HSA-1500620
HDR through Homologous Recombination (HRR) R-HSA-5685942
Cell Cycle R-HSA-1640170
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Gene expression (Transcription) R-HSA-74160
Cellular responses to stress R-HSA-2262752
Fanconi Anemia Pathway R-HSA-6783310
Cellular responses to stimuli R-HSA-8953897
Meiotic synapsis R-HSA-1221632
DNA Double-Strand Break Repair R-HSA-5693532
Homology Directed Repair R-HSA-5693538
Reproduction R-HSA-1474165
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity R-HSA-5633007
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Cellular response to heat stress R-HSA-3371556
Transcriptional Regulation by TP53 R-HSA-3700989
HDR through Single Strand Annealing (SSA) R-HSA-5685938
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Generic Transcription Pathway R-HSA-212436
Disease R-HSA-1643685
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cellular responses to stress R-HSA-2262752
Activation of ATR in response to replication stress R-HSA-176187
G2/M DNA damage checkpoint R-HSA-69473
Gene expression (Transcription) R-HSA-74160
Meiotic synapsis R-HSA-1221632
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G2/M Checkpoints R-HSA-69481
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
DNA Repair R-HSA-73894
DNA Double-Strand Break Repair R-HSA-5693532
Cellular response to heat stress R-HSA-3371556
Cell Cycle R-HSA-1640170
Cellular responses to stimuli R-HSA-8953897
Homology Directed Repair R-HSA-5693538
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle Checkpoints R-HSA-69620
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Reproduction R-HSA-1474165
Fanconi Anemia Pathway R-HSA-6783310
Generic Transcription Pathway R-HSA-212436
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Meiosis R-HSA-1500620
Diseases of DNA repair R-HSA-9675135
HDR through Homologous Recombination (HRR) R-HSA-5685942
Processing of DNA double-strand break ends R-HSA-5693607
Transcriptional Regulation by TP53 R-HSA-3700989
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cellular responses to stress R-HSA-2262752
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Regulation of TP53 Activity R-HSA-5633007
Diseases of DNA repair R-HSA-9675135
G2/M DNA damage checkpoint R-HSA-69473
Homology Directed Repair R-HSA-5693538
Processing of DNA double-strand break ends R-HSA-5693607
Fanconi Anemia Pathway R-HSA-6783310
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Double-Strand Break Repair R-HSA-5693532
Generic Transcription Pathway R-HSA-212436
Activation of ATR in response to replication stress R-HSA-176187
Regulation of HSF1-mediated heat shock response R-HSA-3371453
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Meiotic synapsis R-HSA-1221632
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
G2/M Checkpoints R-HSA-69481
Disease R-HSA-1643685
Cellular response to heat stress R-HSA-3371556
Meiosis R-HSA-1500620
Reproduction R-HSA-1474165
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) R-HSA-5685942
Cell Cycle R-HSA-1640170
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Gene expression (Transcription) R-HSA-74160
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Meiosis R-HSA-1500620
Fanconi Anemia Pathway R-HSA-6783310
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Diseases of DNA repair R-HSA-9675135
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle R-HSA-1640170
Cellular responses to stress R-HSA-2262752
Reproduction R-HSA-1474165
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Generic Transcription Pathway R-HSA-212436
G2/M DNA damage checkpoint R-HSA-69473
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HDR through Single Strand Annealing (SSA) R-HSA-5685938
DNA Repair R-HSA-73894
Meiotic synapsis R-HSA-1221632
Cellular response to heat stress R-HSA-3371556
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Cellular responses to stimuli R-HSA-8953897
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
HDR through Homologous Recombination (HRR) R-HSA-5685942
Processing of DNA double-strand break ends R-HSA-5693607
Gene expression (Transcription) R-HSA-74160
Disease R-HSA-1643685
Regulation of TP53 Activity R-HSA-5633007
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G2/M Checkpoints R-HSA-69481
DNA Double-Strand Break Repair R-HSA-5693532
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Cellular response to heat stress R-HSA-3371556
Gene expression (Transcription) R-HSA-74160
Meiotic synapsis R-HSA-1221632
Cell Cycle R-HSA-1640170
Cellular responses to stress R-HSA-2262752
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cell Cycle Checkpoints R-HSA-69620
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Diseases of DNA repair R-HSA-9675135
Cellular responses to stimuli R-HSA-8953897
Processing of DNA double-strand break ends R-HSA-5693607
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Impaired BRCA2 binding to RAD51 R-HSA-9709570
G2/M DNA damage checkpoint R-HSA-69473
DNA Repair R-HSA-73894
Disease R-HSA-1643685
Regulation of TP53 Activity R-HSA-5633007
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Activation of ATR in response to replication stress R-HSA-176187
G2/M Checkpoints R-HSA-69481
Meiosis R-HSA-1500620
Reproduction R-HSA-1474165
HDR through Homologous Recombination (HRR) R-HSA-5685942
Generic Transcription Pathway R-HSA-212436
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by TP53 R-HSA-3700989
HDR through Single Strand Annealing (SSA) R-HSA-5685938
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Homology Directed Repair R-HSA-5693538
Fanconi Anemia Pathway R-HSA-6783310
Homology Directed Repair R-HSA-5693538
Fanconi Anemia Pathway R-HSA-6783310
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Meiosis R-HSA-1500620
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
Cellular responses to stimuli R-HSA-8953897
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
HDR through Single Strand Annealing (SSA) R-HSA-5685938
Regulation of TP53 Activity R-HSA-5633007
Activation of ATR in response to replication stress R-HSA-176187
Cellular response to heat stress R-HSA-3371556
HDR through Homologous Recombination (HRR) R-HSA-5685942
Gene expression (Transcription) R-HSA-74160
Processing of DNA double-strand break ends R-HSA-5693607
Reproduction R-HSA-1474165
G2/M Checkpoints R-HSA-69481
Diseases of DNA repair R-HSA-9675135
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Meiotic synapsis R-HSA-1221632
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Disease R-HSA-1643685
Regulation of HSF1-mediated heat shock response R-HSA-3371453
DNA Double-Strand Break Repair R-HSA-5693532
Cellular responses to stress R-HSA-2262752
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989

Expression Atlas ENSG00000175054
LRG display in Ensembl gene LRG_1403
NCBI gene (formerly Entrezgene) 545
GeneCards 882
HGNC Symbol HGNC:882
MIM gene 601215
MIM morbid 614564
UniProtKB Gene Name Q13535
WikiGene 545
Gene: MAP3K12
Ensembl ID : ENSG00000139625
Description: mitogen-activated protein kinase kinase kinase 12
Gene Synonyms: DLK,MEKK12,MUK,ZPK,ZPKP1
1 APIs:
254 Possible Orthologues:

Expression Atlas ENSG00000139625
NCBI gene (formerly Entrezgene) 7786
GeneCards 6851
HGNC Symbol HGNC:6851
MIM gene 600447
UniProtKB Gene Name Q12852
WikiGene 7786
Gene: ALK
Ensembl ID : ENSG00000171094
Description: ALK receptor tyrosine kinase
Gene Synonyms: ALK1,CD246
11 APIs:
195 Possible Orthologues:

ALK mutants bind TKIs R-HSA-9700645
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK R-HSA-201556
ceritinib-resistant ALK mutants R-HSA-9717323
crizotinib-resistant ALK mutants R-HSA-9717326
Signal Transduction R-HSA-162582
ASP-3026-resistant ALK mutants R-HSA-9717264
lorlatinib-resistant ALK mutants R-HSA-9717329
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
Disease R-HSA-1643685
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NVP-TAE684-resistant ALK mutants R-HSA-9717301
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK in cancer R-HSA-9700206
alectinib-resistant ALK mutants R-HSA-9717316
brigatinib-resistant ALK mutants R-HSA-9717319
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK in cancer R-HSA-9700206
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Disease R-HSA-1643685
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by ALK fusions and activated point mutants R-HSA-9725370
ASP-3026-resistant ALK mutants R-HSA-9717264
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK R-HSA-201556
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
brigatinib-resistant ALK mutants R-HSA-9717319
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ALK R-HSA-201556
crizotinib-resistant ALK mutants R-HSA-9717326
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
ASP-3026-resistant ALK mutants R-HSA-9717264
Drug resistance of ALK mutants R-HSA-9700649
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by ALK in cancer R-HSA-9700206
NVP-TAE684-resistant ALK mutants R-HSA-9717301
lorlatinib-resistant ALK mutants R-HSA-9717329
Signal Transduction R-HSA-162582
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
ALK mutants bind TKIs R-HSA-9700645
ASP-3026-resistant ALK mutants R-HSA-9717264
Disease R-HSA-1643685
brigatinib-resistant ALK mutants R-HSA-9717319
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK in cancer R-HSA-9700206
Drug resistance of ALK mutants R-HSA-9700649
Signal Transduction R-HSA-162582
NVP-TAE684-resistant ALK mutants R-HSA-9717301
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK fusions and activated point mutants R-HSA-9725370
lorlatinib-resistant ALK mutants R-HSA-9717329
Signaling by ALK R-HSA-201556
brigatinib-resistant ALK mutants R-HSA-9717319
ceritinib-resistant ALK mutants R-HSA-9717323
Signal Transduction R-HSA-162582
Signaling by ALK fusions and activated point mutants R-HSA-9725370
lorlatinib-resistant ALK mutants R-HSA-9717329
Drug resistance of ALK mutants R-HSA-9700649
alectinib-resistant ALK mutants R-HSA-9717316
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK R-HSA-201556
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ASP-3026-resistant ALK mutants R-HSA-9717264
Signaling by ALK in cancer R-HSA-9700206
crizotinib-resistant ALK mutants R-HSA-9717326
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
ALK mutants bind TKIs R-HSA-9700645
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
NVP-TAE684-resistant ALK mutants R-HSA-9717301
lorlatinib-resistant ALK mutants R-HSA-9717329
ASP-3026-resistant ALK mutants R-HSA-9717264
ceritinib-resistant ALK mutants R-HSA-9717323
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
brigatinib-resistant ALK mutants R-HSA-9717319
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
alectinib-resistant ALK mutants R-HSA-9717316
crizotinib-resistant ALK mutants R-HSA-9717326
Signaling by ALK R-HSA-201556
Signal Transduction R-HSA-162582
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK R-HSA-201556
ceritinib-resistant ALK mutants R-HSA-9717323
ASP-3026-resistant ALK mutants R-HSA-9717264
brigatinib-resistant ALK mutants R-HSA-9717319
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK in cancer R-HSA-9700206
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
crizotinib-resistant ALK mutants R-HSA-9717326
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Drug resistance of ALK mutants R-HSA-9700649
lorlatinib-resistant ALK mutants R-HSA-9717329
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signal Transduction R-HSA-162582
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
alectinib-resistant ALK mutants R-HSA-9717316
Disease R-HSA-1643685
Signaling by ALK R-HSA-201556
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ALK mutants bind TKIs R-HSA-9700645
Drug resistance of ALK mutants R-HSA-9700649
crizotinib-resistant ALK mutants R-HSA-9717326
ceritinib-resistant ALK mutants R-HSA-9717323
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Signaling by ALK in cancer R-HSA-9700206
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
ASP-3026-resistant ALK mutants R-HSA-9717264
alectinib-resistant ALK mutants R-HSA-9717316
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ALK R-HSA-201556
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
Drug resistance of ALK mutants R-HSA-9700649
lorlatinib-resistant ALK mutants R-HSA-9717329
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by ALK in cancer R-HSA-9700206
ASP-3026-resistant ALK mutants R-HSA-9717264
alectinib-resistant ALK mutants R-HSA-9717316
ceritinib-resistant ALK mutants R-HSA-9717323
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
alectinib-resistant ALK mutants R-HSA-9717316
Signaling by ALK in cancer R-HSA-9700206
ASP-3026-resistant ALK mutants R-HSA-9717264
Signal Transduction R-HSA-162582
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK R-HSA-201556
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ceritinib-resistant ALK mutants R-HSA-9717323
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
crizotinib-resistant ALK mutants R-HSA-9717326
brigatinib-resistant ALK mutants R-HSA-9717319

Expression Atlas ENSG00000171094
LRG display in Ensembl gene LRG_488
NCBI gene (formerly Entrezgene) 238
GeneCards 427
HGNC Symbol HGNC:427
MIM gene 105590
MIM morbid 613014
UniProtKB Gene Name Q9UM73
WikiGene 238
Gene: JAK2
Ensembl ID : ENSG00000096968
Description: Janus kinase 2
Gene Synonyms: JTK10
23 APIs:
265 Possible Orthologues:

G1 Phase R-HSA-69236
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-2 family signaling R-HSA-451927
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Interleukin-6 signaling R-HSA-1059683
Interleukin-6 family signaling R-HSA-6783589
Mitotic G1 phase and G1/S transition R-HSA-453279
Chromatin organization R-HSA-4839726
Erythropoietin activates RAS R-HSA-9027284
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Infectious disease R-HSA-5663205
Cell Cycle, Mitotic R-HSA-69278
SARS-CoV Infections R-HSA-9679506
Signaling downstream of RAS mutants R-HSA-9649948
Interleukin-23 signaling R-HSA-9020933
Signaling by KIT in disease R-HSA-9669938
RAF activation R-HSA-5673000
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
G1 Phase R-HSA-69236
Interferon gamma signaling R-HSA-877300
Interleukin-12 signaling R-HSA-9020591
Interleukin-35 Signalling R-HSA-8984722
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Growth hormone receptor signaling R-HSA-982772
Cyclin D associated events in G1 R-HSA-69231
Interleukin-12 family signaling R-HSA-447115
MAPK family signaling cascades R-HSA-5683057
Signaling by Erythropoietin R-HSA-9006335
Prolactin receptor signaling R-HSA-1170546
Interleukin-27 signaling R-HSA-9020956
Disease R-HSA-1643685
Hemostasis R-HSA-109582
RMTs methylate histone arginines R-HSA-3214858
Potential therapeutics for SARS R-HSA-9679191
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Erythropoietin activates STAT5 R-HSA-9027283
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-20 family signaling R-HSA-8854691
Signaling by Leptin R-HSA-2586552
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
Signaling by SCF-KIT R-HSA-1433557
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
Signaling by RAS mutants R-HSA-6802949
Immune System R-HSA-168256
Interferon Signaling R-HSA-913531
Signaling by Interleukins R-HSA-449147
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Chromatin modifying enzymes R-HSA-3247509
Regulation of IFNG signaling R-HSA-877312
Signaling by RAF1 mutants R-HSA-9656223
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Cell Cycle R-HSA-1640170
Interleukin receptor SHC signaling R-HSA-912526
Interleukin-2 family signaling R-HSA-451927
Signaling by Leptin R-HSA-2586552
Interleukin-6 family signaling R-HSA-6783589
Cell Cycle R-HSA-1640170
Signal Transduction R-HSA-162582
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Signaling by SCF-KIT R-HSA-1433557
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Chromatin modifying enzymes R-HSA-3247509
Interleukin-12 family signaling R-HSA-447115
Growth hormone receptor signaling R-HSA-982772
Potential therapeutics for SARS R-HSA-9679191
Erythropoietin activates RAS R-HSA-9027284
Interferon Signaling R-HSA-913531
Interleukin-27 signaling R-HSA-9020956
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Interleukin-12 signaling R-HSA-9020591
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-23 signaling R-HSA-9020933
Interferon gamma signaling R-HSA-877300
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Regulation of IFNG signaling R-HSA-877312
Disease R-HSA-1643685
Interleukin-20 family signaling R-HSA-8854691
RAF-independent MAPK1/3 activation R-HSA-112409
Cyclin D associated events in G1 R-HSA-69231
Signaling by Erythropoietin R-HSA-9006335
Erythropoietin activates STAT5 R-HSA-9027283
MAPK family signaling cascades R-HSA-5683057
Signaling by RAF1 mutants R-HSA-9656223
Cytokine Signaling in Immune system R-HSA-1280215
Chromatin organization R-HSA-4839726
RMTs methylate histone arginines R-HSA-3214858
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
G1 Phase R-HSA-69236
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Interleukin-35 Signalling R-HSA-8984722
Factors involved in megakaryocyte development and platelet production R-HSA-983231
MAPK3 (ERK1) activation R-HSA-110056
Infectious disease R-HSA-5663205
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Prolactin receptor signaling R-HSA-1170546
Mitotic G1 phase and G1/S transition R-HSA-453279
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-6 signaling R-HSA-1059683
Signaling by RAS mutants R-HSA-6802949
Interleukin receptor SHC signaling R-HSA-912526
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Cell Cycle, Mitotic R-HSA-69278
Signaling by KIT in disease R-HSA-9669938
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Hemostasis R-HSA-109582
Signaling by CSF3 (G-CSF) R-HSA-9674555
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
SARS-CoV Infections R-HSA-9679506
RAF/MAP kinase cascade R-HSA-5673001
Chromatin modifying enzymes R-HSA-3247509
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Cell Cycle R-HSA-1640170
Interleukin-12 family signaling R-HSA-447115
Interleukin-35 Signalling R-HSA-8984722
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Interleukin-6 signaling R-HSA-1059683
Immune System R-HSA-168256
Interleukin receptor SHC signaling R-HSA-912526
G1 Phase R-HSA-69236
Growth hormone receptor signaling R-HSA-982772
Interferon Signaling R-HSA-913531
Signaling by Erythropoietin R-HSA-9006335
RAF activation R-HSA-5673000
Erythropoietin activates STAT5 R-HSA-9027283
Erythropoietin activates RAS R-HSA-9027284
Interferon gamma signaling R-HSA-877300
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-20 family signaling R-HSA-8854691
Interleukin-6 family signaling R-HSA-6783589
Interleukin-27 signaling R-HSA-9020956
Infectious disease R-HSA-5663205
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Mitotic G1 phase and G1/S transition R-HSA-453279
Regulation of IFNG signaling R-HSA-877312
Potential therapeutics for SARS R-HSA-9679191
Prolactin receptor signaling R-HSA-1170546
MAPK3 (ERK1) activation R-HSA-110056
Signaling by SCF-KIT R-HSA-1433557
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Disease R-HSA-1643685
Interleukin-23 signaling R-HSA-9020933
Signal Transduction R-HSA-162582
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Signaling by RAS mutants R-HSA-6802949
Cell Cycle, Mitotic R-HSA-69278
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV Infections R-HSA-9679506
MAPK family signaling cascades R-HSA-5683057
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Cyclin D associated events in G1 R-HSA-69231
RMTs methylate histone arginines R-HSA-3214858
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Interleukins R-HSA-449147
Signaling by KIT in disease R-HSA-9669938
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-12 signaling R-HSA-9020591
Signaling by Leptin R-HSA-2586552
Chromatin organization R-HSA-4839726
Signaling downstream of RAS mutants R-HSA-9649948
Interleukin-2 family signaling R-HSA-451927
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK1 (ERK2) activation R-HSA-112411
Hemostasis R-HSA-109582
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-23 signaling R-HSA-9020933
Signaling downstream of RAS mutants R-HSA-9649948
Potential therapeutics for SARS R-HSA-9679191
Interleukin-2 family signaling R-HSA-451927
Erythropoietin activates STAT5 R-HSA-9027283
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Prolactin receptor signaling R-HSA-1170546
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RMTs methylate histone arginines R-HSA-3214858
MAPK1 (ERK2) activation R-HSA-112411
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Interferon gamma signaling R-HSA-877300
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-20 family signaling R-HSA-8854691
Cell Cycle R-HSA-1640170
Hemostasis R-HSA-109582
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Interleukin-35 Signalling R-HSA-8984722
Cell Cycle, Mitotic R-HSA-69278
Signal Transduction R-HSA-162582
Chromatin modifying enzymes R-HSA-3247509
Disease R-HSA-1643685
Signaling by CSF3 (G-CSF) R-HSA-9674555
G1 Phase R-HSA-69236
Cyclin D associated events in G1 R-HSA-69231
Infectious disease R-HSA-5663205
Signaling by Interleukins R-HSA-449147
Signaling by RAS mutants R-HSA-6802949
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Chromatin organization R-HSA-4839726
MAPK3 (ERK1) activation R-HSA-110056
Signaling by KIT in disease R-HSA-9669938
Interferon Signaling R-HSA-913531
Signaling by SCF-KIT R-HSA-1433557
MAPK family signaling cascades R-HSA-5683057
Interleukin-6 signaling R-HSA-1059683
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF-independent MAPK1/3 activation R-HSA-112409
Erythropoietin activates RAS R-HSA-9027284
Signaling by RAF1 mutants R-HSA-9656223
RAF activation R-HSA-5673000
Factors involved in megakaryocyte development and platelet production R-HSA-983231
SARS-CoV Infections R-HSA-9679506
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Regulation of IFNG signaling R-HSA-877312
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Oncogenic MAPK signaling R-HSA-6802957
Immune System R-HSA-168256
Signaling by Leptin R-HSA-2586552
Interleukin-12 family signaling R-HSA-447115
Interleukin-27 signaling R-HSA-9020956
Interleukin receptor SHC signaling R-HSA-912526
Mitotic G1 phase and G1/S transition R-HSA-453279
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-6 family signaling R-HSA-6783589
Signaling by Erythropoietin R-HSA-9006335
Interleukin-12 signaling R-HSA-9020591
Growth hormone receptor signaling R-HSA-982772
Interleukin-20 family signaling R-HSA-8854691
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Immune System R-HSA-168256
Regulation of IFNG signaling R-HSA-877312
Chromatin modifying enzymes R-HSA-3247509
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Chromatin organization R-HSA-4839726
Erythropoietin activates STAT5 R-HSA-9027283
Potential therapeutics for SARS R-HSA-9679191
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
SARS-CoV Infections R-HSA-9679506
Oncogenic MAPK signaling R-HSA-6802957
G1 Phase R-HSA-69236
Interleukin-12 family signaling R-HSA-447115
Cyclin D associated events in G1 R-HSA-69231
Interleukin-27 signaling R-HSA-9020956
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Erythropoietin activates RAS R-HSA-9027284
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Interleukin-6 signaling R-HSA-1059683
Signaling by Interleukins R-HSA-449147
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Hemostasis R-HSA-109582
Signaling by RAF1 mutants R-HSA-9656223
Cell Cycle R-HSA-1640170
Mitotic G1 phase and G1/S transition R-HSA-453279
Factors involved in megakaryocyte development and platelet production R-HSA-983231
RAF-independent MAPK1/3 activation R-HSA-112409
Growth hormone receptor signaling R-HSA-982772
Signaling by KIT in disease R-HSA-9669938
Cytokine Signaling in Immune system R-HSA-1280215
MAPK1 (ERK2) activation R-HSA-112411
RMTs methylate histone arginines R-HSA-3214858
Cell Cycle, Mitotic R-HSA-69278
Interferon gamma signaling R-HSA-877300
Signaling by Erythropoietin R-HSA-9006335
Prolactin receptor signaling R-HSA-1170546
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-35 Signalling R-HSA-8984722
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Interleukin receptor SHC signaling R-HSA-912526
Interferon Signaling R-HSA-913531
Signaling by RAS mutants R-HSA-6802949
Interleukin-2 family signaling R-HSA-451927
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-6 family signaling R-HSA-6783589
Disease R-HSA-1643685
MAPK family signaling cascades R-HSA-5683057
RAF activation R-HSA-5673000
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Signaling by SCF-KIT R-HSA-1433557
Interleukin-12 signaling R-HSA-9020591
Signaling by Leptin R-HSA-2586552
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Infectious disease R-HSA-5663205
Interleukin-23 signaling R-HSA-9020933
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Leptin R-HSA-2586552
Hemostasis R-HSA-109582
Regulation of IFNG signaling R-HSA-877312
Growth hormone receptor signaling R-HSA-982772
RAF activation R-HSA-5673000
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Interferon Signaling R-HSA-913531
Prolactin receptor signaling R-HSA-1170546
Cell Cycle R-HSA-1640170
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by RAS mutants R-HSA-6802949
Signaling by KIT in disease R-HSA-9669938
Signaling by Interleukins R-HSA-449147
Cyclin D associated events in G1 R-HSA-69231
RMTs methylate histone arginines R-HSA-3214858
Interleukin-2 family signaling R-HSA-451927
SARS-CoV Infections R-HSA-9679506
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Erythropoietin R-HSA-9006335
Disease R-HSA-1643685
Erythropoietin activates STAT5 R-HSA-9027283
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Chromatin modifying enzymes R-HSA-3247509
Erythropoietin activates RAS R-HSA-9027284
Interleukin-12 family signaling R-HSA-447115
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-6 family signaling R-HSA-6783589
Infectious disease R-HSA-5663205
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Interleukin receptor SHC signaling R-HSA-912526
Signaling by BRAF and RAF1 fusions R-HSA-6802952
G1 Phase R-HSA-69236
Signaling downstream of RAS mutants R-HSA-9649948
Interleukin-23 signaling R-HSA-9020933
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
MAPK1 (ERK2) activation R-HSA-112411
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interleukin-12 signaling R-HSA-9020591
Interleukin-6 signaling R-HSA-1059683
Chromatin organization R-HSA-4839726
Immune System R-HSA-168256
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle, Mitotic R-HSA-69278
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
Interleukin-27 signaling R-HSA-9020956
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Potential therapeutics for SARS R-HSA-9679191
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Signaling by CSF3 (G-CSF) R-HSA-9674555
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-20 family signaling R-HSA-8854691
Interleukin-35 Signalling R-HSA-8984722
Signaling by SCF-KIT R-HSA-1433557
Oncogenic MAPK signaling R-HSA-6802957
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
MAPK1/MAPK3 signaling R-HSA-5684996
Interferon gamma signaling R-HSA-877300
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Signaling by RAF1 mutants R-HSA-9656223
Signal Transduction R-HSA-162582
Interleukin-6 family signaling R-HSA-6783589
Cell Cycle, Mitotic R-HSA-69278
Interleukin-6 signaling R-HSA-1059683
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin receptor SHC signaling R-HSA-912526
Interleukin-23 signaling R-HSA-9020933
Signaling by Leptin R-HSA-2586552
Cyclin D associated events in G1 R-HSA-69231
RAF-independent MAPK1/3 activation R-HSA-112409
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interleukin-12 signaling R-HSA-9020591
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Cytokine Signaling in Immune system R-HSA-1280215
Chromatin modifying enzymes R-HSA-3247509
Oncogenic MAPK signaling R-HSA-6802957
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-20 family signaling R-HSA-8854691
Signaling by Erythropoietin R-HSA-9006335
Interferon gamma signaling R-HSA-877300
Hemostasis R-HSA-109582
Signaling by SCF-KIT R-HSA-1433557
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Interleukin-2 family signaling R-HSA-451927
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Erythropoietin activates RAS R-HSA-9027284
Prolactin receptor signaling R-HSA-1170546
Regulation of IFNG signaling R-HSA-877312
Interleukin-27 signaling R-HSA-9020956
RAF/MAP kinase cascade R-HSA-5673001
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Growth hormone receptor signaling R-HSA-982772
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by KIT in disease R-HSA-9669938
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
SARS-CoV Infections R-HSA-9679506
RMTs methylate histone arginines R-HSA-3214858
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Chromatin organization R-HSA-4839726
Signaling by RAS mutants R-HSA-6802949
Infectious disease R-HSA-5663205
Interferon Signaling R-HSA-913531
Interleukin-12 family signaling R-HSA-447115
Potential therapeutics for SARS R-HSA-9679191
Mitotic G1 phase and G1/S transition R-HSA-453279
Erythropoietin activates STAT5 R-HSA-9027283
MAPK family signaling cascades R-HSA-5683057
Cell Cycle R-HSA-1640170
Interleukin-35 Signalling R-HSA-8984722
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
MAPK3 (ERK1) activation R-HSA-110056
RAF activation R-HSA-5673000
G1 Phase R-HSA-69236
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Disease R-HSA-1643685
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Infectious disease R-HSA-5663205
Cell Cycle, Mitotic R-HSA-69278
Interferon Signaling R-HSA-913531
Signaling downstream of RAS mutants R-HSA-9649948
Interleukin-23 signaling R-HSA-9020933
G1 Phase R-HSA-69236
Potential therapeutics for SARS R-HSA-9679191
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interleukin-12 family signaling R-HSA-447115
Signaling by KIT in disease R-HSA-9669938
Disease R-HSA-1643685
Interleukin-12 signaling R-HSA-9020591
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Signal Transduction R-HSA-162582
Interleukin-35 Signalling R-HSA-8984722
Chromatin organization R-HSA-4839726
Cyclin D associated events in G1 R-HSA-69231
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Signaling by RAF1 mutants R-HSA-9656223
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Oncogenic MAPK signaling R-HSA-6802957
Interleukin receptor SHC signaling R-HSA-912526
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
RMTs methylate histone arginines R-HSA-3214858
Chromatin modifying enzymes R-HSA-3247509
MAPK3 (ERK1) activation R-HSA-110056
RAF activation R-HSA-5673000
Signaling by Interleukins R-HSA-449147
Cell Cycle R-HSA-1640170
Signaling by Erythropoietin R-HSA-9006335
Hemostasis R-HSA-109582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by CSF3 (G-CSF) R-HSA-9674555
Growth hormone receptor signaling R-HSA-982772
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Interleukin-20 family signaling R-HSA-8854691
Mitotic G1 phase and G1/S transition R-HSA-453279
Cytokine Signaling in Immune system R-HSA-1280215
Regulation of IFNG signaling R-HSA-877312
Prolactin receptor signaling R-HSA-1170546
MAPK1 (ERK2) activation R-HSA-112411
Interleukin-27 signaling R-HSA-9020956
MAPK family signaling cascades R-HSA-5683057
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
RAF-independent MAPK1/3 activation R-HSA-112409
RAF/MAP kinase cascade R-HSA-5673001
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Interleukin-6 family signaling R-HSA-6783589
Interleukin-6 signaling R-HSA-1059683
SARS-CoV Infections R-HSA-9679506
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Interleukin-2 family signaling R-HSA-451927
MAPK1/MAPK3 signaling R-HSA-5684996
Interferon gamma signaling R-HSA-877300
Signaling by SCF-KIT R-HSA-1433557
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Immune System R-HSA-168256
Erythropoietin activates RAS R-HSA-9027284
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAS mutants R-HSA-6802949
Signaling by Leptin R-HSA-2586552
Erythropoietin activates STAT5 R-HSA-9027283
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Growth hormone receptor signaling R-HSA-982772
Signaling by KIT in disease R-HSA-9669938
Interleukin-20 family signaling R-HSA-8854691
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Disease R-HSA-1643685
Interleukin-6 family signaling R-HSA-6783589
Interleukin-2 family signaling R-HSA-451927
Interleukin-12 signaling R-HSA-9020591
Interleukin-6 signaling R-HSA-1059683
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Interleukin receptor SHC signaling R-HSA-912526
Erythropoietin activates STAT5 R-HSA-9027283
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Chromatin organization R-HSA-4839726
Signal Transduction R-HSA-162582
G1 Phase R-HSA-69236
Interleukin-27 signaling R-HSA-9020956
Prolactin receptor signaling R-HSA-1170546
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by CSF3 (G-CSF) R-HSA-9674555
Interleukin-12 family signaling R-HSA-447115
Signaling by Interleukins R-HSA-449147
Signaling downstream of RAS mutants R-HSA-9649948
Immune System R-HSA-168256
MAPK1 (ERK2) activation R-HSA-112411
Cell Cycle R-HSA-1640170
Signaling by Erythropoietin R-HSA-9006335
RMTs methylate histone arginines R-HSA-3214858
Interleukin-23 signaling R-HSA-9020933
Infectious disease R-HSA-5663205
RAF activation R-HSA-5673000
Signaling by Leptin R-HSA-2586552
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Hemostasis R-HSA-109582
Interferon gamma signaling R-HSA-877300
Interleukin-35 Signalling R-HSA-8984722
MAPK1/MAPK3 signaling R-HSA-5684996
Cyclin D associated events in G1 R-HSA-69231
Signaling by RAS mutants R-HSA-6802949
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Cell Cycle, Mitotic R-HSA-69278
RAF/MAP kinase cascade R-HSA-5673001
Potential therapeutics for SARS R-HSA-9679191
MAPK family signaling cascades R-HSA-5683057
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Regulation of IFNG signaling R-HSA-877312
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
SARS-CoV Infections R-HSA-9679506
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cytokine Signaling in Immune system R-HSA-1280215
Interferon Signaling R-HSA-913531
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAPK3 (ERK1) activation R-HSA-110056
Erythropoietin activates RAS R-HSA-9027284
Signaling by RAF1 mutants R-HSA-9656223
Chromatin modifying enzymes R-HSA-3247509
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Mitotic G1 phase and G1/S transition R-HSA-453279
Signaling by SCF-KIT R-HSA-1433557
MAPK3 (ERK1) activation R-HSA-110056
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Interleukin-6 signaling R-HSA-1059683
Chromatin organization R-HSA-4839726
Signaling by KIT in disease R-HSA-9669938
Interleukin-23 signaling R-HSA-9020933
RAF activation R-HSA-5673000
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Mitotic G1 phase and G1/S transition R-HSA-453279
MAPK1 (ERK2) activation R-HSA-112411
Interferon Signaling R-HSA-913531
Signaling by RAS mutants R-HSA-6802949
Interferon gamma signaling R-HSA-877300
Infectious disease R-HSA-5663205
MAPK1/MAPK3 signaling R-HSA-5684996
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
RAF-independent MAPK1/3 activation R-HSA-112409
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Inactivation of CSF3 (G-CSF) signaling R-HSA-9705462
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Interleukin-2 family signaling R-HSA-451927
Interleukin-35 Signalling R-HSA-8984722
Interleukin-12 signaling R-HSA-9020591
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Potential therapeutics for SARS R-HSA-9679191
Signaling by Interleukins R-HSA-449147
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Prolactin receptor signaling R-HSA-1170546
Regulation of IFNG signaling R-HSA-877312
IL-6-type cytokine receptor ligand interactions R-HSA-6788467
Signaling by Leptin R-HSA-2586552
Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9027277
Interleukin-12 family signaling R-HSA-447115
Erythropoietin activates STAT5 R-HSA-9027283
Signaling downstream of RAS mutants R-HSA-9649948
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Hemostasis R-HSA-109582
Interleukin-20 family signaling R-HSA-8854691
Signaling by RAF1 mutants R-HSA-9656223
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cyclin D associated events in G1 R-HSA-69231
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by CSF3 (G-CSF) R-HSA-9674555
Disease R-HSA-1643685
Interleukin-27 signaling R-HSA-9020956
Cell Cycle, Mitotic R-HSA-69278
RAF/MAP kinase cascade R-HSA-5673001
Growth hormone receptor signaling R-HSA-982772
RMTs methylate histone arginines R-HSA-3214858
SARS-CoV Infections R-HSA-9679506
Interleukin receptor SHC signaling R-HSA-912526
Oncogenic MAPK signaling R-HSA-6802957
Cell Cycle R-HSA-1640170
Chromatin modifying enzymes R-HSA-3247509
Signaling by SCF-KIT R-HSA-1433557
Interleukin-6 family signaling R-HSA-6783589
Erythropoietin activates RAS R-HSA-9027284
Immune System R-HSA-168256
Signaling by Erythropoietin R-HSA-9006335

Expression Atlas ENSG00000096968
LRG display in Ensembl gene LRG_612
NCBI gene (formerly Entrezgene) 3717
GeneCards 6192
HGNC Symbol HGNC:6192
MIM gene 147796
MIM morbid 614521
UniProtKB Gene Name O60674
WikiGene 3717