Gene: NTRK1
Ensembl ID : ENSG00000198400
Description: neurotrophic receptor tyrosine kinase 1
Gene Synonyms: MTC,TRK,TRKA
6 APIs:
200 Possible Orthologues:

Signalling to p38 via RIT and RIN R-HSA-187706
Signalling to ERKs R-HSA-187687
Prolonged ERK activation events R-HSA-169893
Signalling to STAT3 R-HSA-198745
Signalling to p38 via RIT and RIN R-HSA-187706
PLC-gamma1 signalling R-HSA-167021
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Frs2-mediated activation R-HSA-170968
ARMS-mediated activation R-HSA-170984
NGF-independant TRKA activation R-HSA-187024
Signaling by NTRK1 (TRKA) R-HSA-187037
Activation of TRKA receptors R-HSA-187015
TRKA activation by NGF R-HSA-187042
PI3K/AKT activation R-HSA-198203
Signaling by NTRKs R-HSA-166520
Signal Transduction R-HSA-162582
Signalling to RAS R-HSA-167044
Retrograde neurotrophin signalling R-HSA-177504
Activation of TRKA receptors R-HSA-187015
Signaling by NTRK1 (TRKA) R-HSA-187037
Retrograde neurotrophin signalling R-HSA-177504
PLC-gamma1 signalling R-HSA-167021
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NGF-independant TRKA activation R-HSA-187024
Signal Transduction R-HSA-162582
Signaling by NTRKs R-HSA-166520
Signalling to p38 via RIT and RIN R-HSA-187706
PI3K/AKT activation R-HSA-198203
TRKA activation by NGF R-HSA-187042
Prolonged ERK activation events R-HSA-169893
ARMS-mediated activation R-HSA-170984
Signalling to STAT3 R-HSA-198745
Signalling to ERKs R-HSA-187687
Signalling to RAS R-HSA-167044
Frs2-mediated activation R-HSA-170968
Signalling to ERKs R-HSA-187687
Prolonged ERK activation events R-HSA-169893
ARMS-mediated activation R-HSA-170984
Frs2-mediated activation R-HSA-170968
Activation of TRKA receptors R-HSA-187015
PLC-gamma1 signalling R-HSA-167021
Signalling to STAT3 R-HSA-198745
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K/AKT activation R-HSA-198203
Signal Transduction R-HSA-162582
TRKA activation by NGF R-HSA-187042
Signaling by NTRKs R-HSA-166520
NGF-independant TRKA activation R-HSA-187024
Signalling to RAS R-HSA-167044
Signalling to p38 via RIT and RIN R-HSA-187706
Retrograde neurotrophin signalling R-HSA-177504
PLC-gamma1 signalling R-HSA-167021
Signaling by NTRK1 (TRKA) R-HSA-187037
Signal Transduction R-HSA-162582
NGF-independant TRKA activation R-HSA-187024
Frs2-mediated activation R-HSA-170968
Signalling to STAT3 R-HSA-198745
Retrograde neurotrophin signalling R-HSA-177504
Activation of TRKA receptors R-HSA-187015
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
TRKA activation by NGF R-HSA-187042
PI3K/AKT activation R-HSA-198203
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
ARMS-mediated activation R-HSA-170984
Signalling to RAS R-HSA-167044
Prolonged ERK activation events R-HSA-169893
Retrograde neurotrophin signalling R-HSA-177504
PLC-gamma1 signalling R-HSA-167021
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
Signal Transduction R-HSA-162582
Activation of TRKA receptors R-HSA-187015
ARMS-mediated activation R-HSA-170984
Signaling by NTRK1 (TRKA) R-HSA-187037
TRKA activation by NGF R-HSA-187042
Signalling to STAT3 R-HSA-198745
Signalling to p38 via RIT and RIN R-HSA-187706
PI3K/AKT activation R-HSA-198203
NGF-independant TRKA activation R-HSA-187024
Frs2-mediated activation R-HSA-170968
Signalling to RAS R-HSA-167044
Prolonged ERK activation events R-HSA-169893
Signalling to STAT3 R-HSA-198745
Signalling to ERKs R-HSA-187687
TRKA activation by NGF R-HSA-187042
Signaling by NTRKs R-HSA-166520
Signal Transduction R-HSA-162582
PI3K/AKT activation R-HSA-198203
Signalling to p38 via RIT and RIN R-HSA-187706
Signalling to RAS R-HSA-167044
Frs2-mediated activation R-HSA-170968
Prolonged ERK activation events R-HSA-169893
Activation of TRKA receptors R-HSA-187015
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ARMS-mediated activation R-HSA-170984
Retrograde neurotrophin signalling R-HSA-177504
PLC-gamma1 signalling R-HSA-167021
NGF-independant TRKA activation R-HSA-187024
Signalling to STAT3 R-HSA-198745
NGF-independant TRKA activation R-HSA-187024
Signaling by NTRK1 (TRKA) R-HSA-187037
Signal Transduction R-HSA-162582
Activation of TRKA receptors R-HSA-187015
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signalling to ERKs R-HSA-187687
Signaling by NTRKs R-HSA-166520
Signalling to RAS R-HSA-167044
Retrograde neurotrophin signalling R-HSA-177504
Prolonged ERK activation events R-HSA-169893
Frs2-mediated activation R-HSA-170968
PI3K/AKT activation R-HSA-198203
PLC-gamma1 signalling R-HSA-167021
ARMS-mediated activation R-HSA-170984
Signalling to p38 via RIT and RIN R-HSA-187706
TRKA activation by NGF R-HSA-187042
Signalling to RAS R-HSA-167044
Signalling to STAT3 R-HSA-198745
PLC-gamma1 signalling R-HSA-167021
Signalling to ERKs R-HSA-187687
PI3K/AKT activation R-HSA-198203
Retrograde neurotrophin signalling R-HSA-177504
Signaling by NTRK1 (TRKA) R-HSA-187037
TRKA activation by NGF R-HSA-187042
Frs2-mediated activation R-HSA-170968
Prolonged ERK activation events R-HSA-169893
ARMS-mediated activation R-HSA-170984
Signaling by NTRKs R-HSA-166520
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
NGF-independant TRKA activation R-HSA-187024
Activation of TRKA receptors R-HSA-187015
Signal Transduction R-HSA-162582
TRKA activation by NGF R-HSA-187042
Activation of TRKA receptors R-HSA-187015
ARMS-mediated activation R-HSA-170984
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Prolonged ERK activation events R-HSA-169893
Signalling to ERKs R-HSA-187687
PLC-gamma1 signalling R-HSA-167021
Signaling by NTRK1 (TRKA) R-HSA-187037
Signalling to p38 via RIT and RIN R-HSA-187706
Retrograde neurotrophin signalling R-HSA-177504
Signaling by NTRKs R-HSA-166520
NGF-independant TRKA activation R-HSA-187024
Signalling to RAS R-HSA-167044
Frs2-mediated activation R-HSA-170968
Signalling to STAT3 R-HSA-198745
PI3K/AKT activation R-HSA-198203
Signalling to STAT3 R-HSA-198745
Signalling to ERKs R-HSA-187687
Frs2-mediated activation R-HSA-170968
Prolonged ERK activation events R-HSA-169893
Signaling by NTRKs R-HSA-166520
PI3K/AKT activation R-HSA-198203
NGF-independant TRKA activation R-HSA-187024
ARMS-mediated activation R-HSA-170984
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by NTRK1 (TRKA) R-HSA-187037
TRKA activation by NGF R-HSA-187042
Activation of TRKA receptors R-HSA-187015
Retrograde neurotrophin signalling R-HSA-177504
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PLC-gamma1 signalling R-HSA-167021
Signalling to RAS R-HSA-167044

Expression Atlas ENSG00000198400
LRG display in Ensembl gene LRG_261
NCBI gene (formerly Entrezgene) 4914
GeneCards 8031
HGNC Symbol HGNC:8031
MIM gene 191315
MIM morbid 256800
UniProtKB Gene Name X5DR71
WikiGene 4914
Gene: EML4
Ensembl ID : ENSG00000143924
Description: EMAP like 4
Gene Synonyms: C2ORF2,ELP120,ROPP120
5 APIs:
214 Possible Orthologues:

ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK in cancer R-HSA-9700206
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
M Phase R-HSA-68886
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Mitotic Prometaphase R-HSA-68877
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
ALK mutants bind TKIs R-HSA-9700645
Disease R-HSA-1643685
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK fusions and activated point mutants R-HSA-9725370
M Phase R-HSA-68886
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
ALK mutants bind TKIs R-HSA-9700645
Cell Cycle R-HSA-1640170
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
M Phase R-HSA-68886
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Cell Cycle, Mitotic R-HSA-69278
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
M Phase R-HSA-68886
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK fusions and activated point mutants R-HSA-9725370
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Mitotic Prometaphase R-HSA-68877
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
M Phase R-HSA-68886
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK in cancer R-HSA-9700206
M Phase R-HSA-68886
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
M Phase R-HSA-68886
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle, Mitotic R-HSA-69278
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
M Phase R-HSA-68886
Cell Cycle, Mitotic R-HSA-69278
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
M Phase R-HSA-68886
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Mitotic Prometaphase R-HSA-68877
Cell Cycle, Mitotic R-HSA-69278
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
Disease R-HSA-1643685
ALK mutants bind TKIs R-HSA-9700645
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by ALK in cancer R-HSA-9700206
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cell Cycle, Mitotic R-HSA-69278
Signaling by ALK in cancer R-HSA-9700206
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Disease R-HSA-1643685
Mitotic Prometaphase R-HSA-68877
ALK mutants bind TKIs R-HSA-9700645
Cell Cycle R-HSA-1640170
EML4 and NUDC in mitotic spindle formation R-HSA-9648025
M Phase R-HSA-68886

Expression Atlas ENSG00000143924
NCBI gene (formerly Entrezgene) 27436
GeneCards 1316
HGNC Symbol HGNC:1316
MIM gene 607442
UniProtKB Gene Name Q9HC35
WikiGene 27436
Gene: FGFR3
Ensembl ID : ENSG00000068078
Description: fibroblast growth factor receptor 3
Gene Synonyms: ACH,CD333,CEK2,JTK4
24 APIs:
196 Possible Orthologues:

IGF1R signaling cascade R-HSA-2428924
t(4;14) translocations of FGFR3 R-HSA-2033515
IRS-related events triggered by IGF1R R-HSA-2428928
Signal Transduction R-HSA-162582
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR3 in disease R-HSA-5655332
Disease R-HSA-1643685
IGF1R signaling cascade R-HSA-2428924
Negative regulation of FGFR3 signaling R-HSA-5654732
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
RAF/MAP kinase cascade R-HSA-5673001
Signaling by FGFR3 fusions in cancer R-HSA-8853334
Insulin receptor signalling cascade R-HSA-74751
FGFR3b ligand binding and activation R-HSA-190371
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR R-HSA-190236
FGFR3 ligand binding and activation R-HSA-190239
PI3K Cascade R-HSA-109704
Signaling by FGFR in disease R-HSA-1226099
FGFR3 mutant receptor activation R-HSA-2033514
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
FGFR3c ligand binding and activation R-HSA-190372
Negative regulation of the PI3K/AKT network R-HSA-199418
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Insulin receptor R-HSA-74752
PI-3K cascade:FGFR3 R-HSA-5654710
IRS-mediated signalling R-HSA-112399
SHC-mediated cascade:FGFR3 R-HSA-5654704
Signaling by activated point mutants of FGFR3 R-HSA-1839130
Signaling by FGFR3 R-HSA-5654741
MAPK1/MAPK3 signaling R-HSA-5684996
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
MAPK family signaling cascades R-HSA-5683057
FRS-mediated FGFR3 signaling R-HSA-5654706
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR in disease R-HSA-1226099
Signaling by FGFR3 in disease R-HSA-5655332
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by Insulin receptor R-HSA-74752
FGFR3 mutant receptor activation R-HSA-2033514
Signaling by FGFR R-HSA-190236
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
MAPK family signaling cascades R-HSA-5683057
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K Cascade R-HSA-109704
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor signalling cascade R-HSA-74751
Negative regulation of the PI3K/AKT network R-HSA-199418
RAF/MAP kinase cascade R-HSA-5673001
PI-3K cascade:FGFR3 R-HSA-5654710
FGFR3 ligand binding and activation R-HSA-190239
t(4;14) translocations of FGFR3 R-HSA-2033515
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Signaling by FGFR3 fusions in cancer R-HSA-8853334
SHC-mediated cascade:FGFR3 R-HSA-5654704
FGFR3c ligand binding and activation R-HSA-190372
Downstream signaling of activated FGFR3 R-HSA-5654708
FGFR3b ligand binding and activation R-HSA-190371
Signaling by activated point mutants of FGFR3 R-HSA-1839130
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
MAPK1/MAPK3 signaling R-HSA-5684996
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR3 R-HSA-5654741
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
IGF1R signaling cascade R-HSA-2428924
PI3K/AKT Signaling in Cancer R-HSA-2219528
Negative regulation of FGFR3 signaling R-HSA-5654732
FGFR3c ligand binding and activation R-HSA-190372
Signaling by activated point mutants of FGFR3 R-HSA-1839130
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
SHC-mediated cascade:FGFR3 R-HSA-5654704
Disease R-HSA-1643685
IGF1R signaling cascade R-HSA-2428924
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
FGFR3 ligand binding and activation R-HSA-190239
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR3 fusions in cancer R-HSA-8853334
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR3 in disease R-HSA-5655332
Negative regulation of the PI3K/AKT network R-HSA-199418
t(4;14) translocations of FGFR3 R-HSA-2033515
Signaling by FGFR in disease R-HSA-1226099
Signal Transduction R-HSA-162582
PIP3 activates AKT signaling R-HSA-1257604
FGFR3 mutant receptor activation R-HSA-2033514
Signaling by Insulin receptor R-HSA-74752
Negative regulation of FGFR3 signaling R-HSA-5654732
FRS-mediated FGFR3 signaling R-HSA-5654706
IRS-related events triggered by IGF1R R-HSA-2428928
FGFR3b ligand binding and activation R-HSA-190371
Intracellular signaling by second messengers R-HSA-9006925
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR R-HSA-190236
IRS-mediated signalling R-HSA-112399
RAF/MAP kinase cascade R-HSA-5673001
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Downstream signaling of activated FGFR3 R-HSA-5654708
Insulin receptor signalling cascade R-HSA-74751
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K Cascade R-HSA-109704
Signaling by FGFR3 fusions in cancer R-HSA-8853334
FGFR3b ligand binding and activation R-HSA-190371
Signaling by FGFR3 in disease R-HSA-5655332
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Downstream signaling of activated FGFR3 R-HSA-5654708
FGFR3 mutant receptor activation R-HSA-2033514
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Negative regulation of the PI3K/AKT network R-HSA-199418
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Insulin receptor signalling cascade R-HSA-74751
IRS-related events triggered by IGF1R R-HSA-2428928
PI3K Cascade R-HSA-109704
PI3K/AKT Signaling in Cancer R-HSA-2219528
Negative regulation of FGFR3 signaling R-HSA-5654732
Intracellular signaling by second messengers R-HSA-9006925
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Insulin receptor R-HSA-74752
FRS-mediated FGFR3 signaling R-HSA-5654706
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
RAF/MAP kinase cascade R-HSA-5673001
Signaling by FGFR R-HSA-190236
PI-3K cascade:FGFR3 R-HSA-5654710
t(4;14) translocations of FGFR3 R-HSA-2033515
Disease R-HSA-1643685
FGFR3 ligand binding and activation R-HSA-190239
Signaling by FGFR in disease R-HSA-1226099
FGFR3c ligand binding and activation R-HSA-190372
Signaling by activated point mutants of FGFR3 R-HSA-1839130
MAPK family signaling cascades R-HSA-5683057
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IGF1R signaling cascade R-HSA-2428924
SHC-mediated cascade:FGFR3 R-HSA-5654704
IRS-mediated signalling R-HSA-112399
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
FGFR3c ligand binding and activation R-HSA-190372
Signal Transduction R-HSA-162582
SHC-mediated cascade:FGFR3 R-HSA-5654704
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Downstream signaling of activated FGFR3 R-HSA-5654708
Intracellular signaling by second messengers R-HSA-9006925
FGFR3b ligand binding and activation R-HSA-190371
PI3K Cascade R-HSA-109704
FRS-mediated FGFR3 signaling R-HSA-5654706
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR in disease R-HSA-1226099
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K/AKT Signaling in Cancer R-HSA-2219528
MAPK1/MAPK3 signaling R-HSA-5684996
t(4;14) translocations of FGFR3 R-HSA-2033515
Signaling by Insulin receptor R-HSA-74752
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR3 R-HSA-5654741
FGFR3 mutant receptor activation R-HSA-2033514
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR R-HSA-190236
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI-3K cascade:FGFR3 R-HSA-5654710
MAPK family signaling cascades R-HSA-5683057
FGFR3 ligand binding and activation R-HSA-190239
IGF1R signaling cascade R-HSA-2428924
Signaling by FGFR3 in disease R-HSA-5655332
Disease R-HSA-1643685
Signaling by activated point mutants of FGFR3 R-HSA-1839130
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
Signaling by FGFR3 fusions in cancer R-HSA-8853334
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR3 in disease R-HSA-5655332
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR3 fusions in cancer R-HSA-8853334
Signaling by FGFR R-HSA-190236
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IRS-mediated signalling R-HSA-112399
t(4;14) translocations of FGFR3 R-HSA-2033515
Negative regulation of FGFR3 signaling R-HSA-5654732
Disease R-HSA-1643685
Signaling by Insulin receptor R-HSA-74752
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR in disease R-HSA-1226099
MAPK family signaling cascades R-HSA-5683057
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by activated point mutants of FGFR3 R-HSA-1839130
FGFR3 ligand binding and activation R-HSA-190239
SHC-mediated cascade:FGFR3 R-HSA-5654704
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signal Transduction R-HSA-162582
FGFR3 mutant receptor activation R-HSA-2033514
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
RAF/MAP kinase cascade R-HSA-5673001
FGFR3b ligand binding and activation R-HSA-190371
PIP3 activates AKT signaling R-HSA-1257604
PI3K Cascade R-HSA-109704
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR3c ligand binding and activation R-HSA-190372
IGF1R signaling cascade R-HSA-2428924
Downstream signaling of activated FGFR3 R-HSA-5654708
IRS-related events triggered by IGF1R R-HSA-2428928
PI-3K cascade:FGFR3 R-HSA-5654710
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Downstream signaling of activated FGFR3 R-HSA-5654708
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signal Transduction R-HSA-162582
PI3K Cascade R-HSA-109704
Signaling by activated point mutants of FGFR3 R-HSA-1839130
Signaling by FGFR in disease R-HSA-1226099
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FGFR R-HSA-190236
Disease R-HSA-1643685
PI-3K cascade:FGFR3 R-HSA-5654710
SHC-mediated cascade:FGFR3 R-HSA-5654704
FGFR3 ligand binding and activation R-HSA-190239
PIP3 activates AKT signaling R-HSA-1257604
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
FGFR3c ligand binding and activation R-HSA-190372
FGFR3 mutant receptor activation R-HSA-2033514
Negative regulation of the PI3K/AKT network R-HSA-199418
IRS-mediated signalling R-HSA-112399
RAF/MAP kinase cascade R-HSA-5673001
t(4;14) translocations of FGFR3 R-HSA-2033515
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR3 signaling R-HSA-5654732
FGFR3b ligand binding and activation R-HSA-190371
Signaling by FGFR3 fusions in cancer R-HSA-8853334
FRS-mediated FGFR3 signaling R-HSA-5654706
Intracellular signaling by second messengers R-HSA-9006925
Signaling by FGFR3 R-HSA-5654741
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR3 in disease R-HSA-5655332
MAPK family signaling cascades R-HSA-5683057
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Insulin receptor R-HSA-74752
Signaling by FGFR in disease R-HSA-1226099
IGF1R signaling cascade R-HSA-2428924
Disease R-HSA-1643685
FRS-mediated FGFR3 signaling R-HSA-5654706
PI3K Cascade R-HSA-109704
Negative regulation of the PI3K/AKT network R-HSA-199418
RAF/MAP kinase cascade R-HSA-5673001
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
IRS-mediated signalling R-HSA-112399
Negative regulation of FGFR3 signaling R-HSA-5654732
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
IRS-related events triggered by IGF1R R-HSA-2428928
PIP3 activates AKT signaling R-HSA-1257604
Signaling by FGFR3 in disease R-HSA-5655332
Signaling by activated point mutants of FGFR3 R-HSA-1839130
PI3K/AKT Signaling in Cancer R-HSA-2219528
MAPK family signaling cascades R-HSA-5683057
Downstream signaling of activated FGFR3 R-HSA-5654708
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by FGFR3 fusions in cancer R-HSA-8853334
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI-3K cascade:FGFR3 R-HSA-5654710
t(4;14) translocations of FGFR3 R-HSA-2033515
Signaling by FGFR3 R-HSA-5654741
Insulin receptor signalling cascade R-HSA-74751
FGFR3 ligand binding and activation R-HSA-190239
FGFR3c ligand binding and activation R-HSA-190372
SHC-mediated cascade:FGFR3 R-HSA-5654704
FGFR3 mutant receptor activation R-HSA-2033514
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
FGFR3b ligand binding and activation R-HSA-190371
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR R-HSA-190236
Signaling by Insulin receptor R-HSA-74752
FGFR3b ligand binding and activation R-HSA-190371
SHC-mediated cascade:FGFR3 R-HSA-5654704
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Signaling by FGFR3 R-HSA-5654741
PI3K Cascade R-HSA-109704
IRS-related events triggered by IGF1R R-HSA-2428928
IRS-mediated signalling R-HSA-112399
FGFR3 mutant receptor activation R-HSA-2033514
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR R-HSA-190236
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR3 in disease R-HSA-5655332
Disease R-HSA-1643685
IGF1R signaling cascade R-HSA-2428924
PI3K/AKT Signaling in Cancer R-HSA-2219528
RAF/MAP kinase cascade R-HSA-5673001
Downstream signaling of activated FGFR3 R-HSA-5654708
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI-3K cascade:FGFR3 R-HSA-5654710
Negative regulation of FGFR3 signaling R-HSA-5654732
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR3 fusions in cancer R-HSA-8853334
FGFR3 ligand binding and activation R-HSA-190239
t(4;14) translocations of FGFR3 R-HSA-2033515
Signaling by activated point mutants of FGFR3 R-HSA-1839130
Insulin receptor signalling cascade R-HSA-74751
Signaling by Insulin receptor R-HSA-74752
FRS-mediated FGFR3 signaling R-HSA-5654706
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR in disease R-HSA-1226099
FGFR3c ligand binding and activation R-HSA-190372
FGFR3 mutant receptor activation R-HSA-2033514
Signaling by FGFR3 R-HSA-5654741
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR in disease R-HSA-1226099
RAF/MAP kinase cascade R-HSA-5673001
FRS-mediated FGFR3 signaling R-HSA-5654706
FGFR3b ligand binding and activation R-HSA-190371
Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227
Signaling by FGFR3 fusions in cancer R-HSA-8853334
PI-3K cascade:FGFR3 R-HSA-5654710
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by activated point mutants of FGFR3 R-HSA-1839130
IGF1R signaling cascade R-HSA-2428924
Negative regulation of FGFR3 signaling R-HSA-5654732
t(4;14) translocations of FGFR3 R-HSA-2033515
Signaling by FGFR3 in disease R-HSA-5655332
IRS-mediated signalling R-HSA-112399
PI3K Cascade R-HSA-109704
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by FGFR R-HSA-190236
Insulin receptor signalling cascade R-HSA-74751
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
FGFR3c ligand binding and activation R-HSA-190372
SHC-mediated cascade:FGFR3 R-HSA-5654704
FGFR3 ligand binding and activation R-HSA-190239
MAPK1/MAPK3 signaling R-HSA-5684996
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IRS-related events triggered by IGF1R R-HSA-2428928
Intracellular signaling by second messengers R-HSA-9006925
Signal Transduction R-HSA-162582
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by Insulin receptor R-HSA-74752

Expression Atlas ENSG00000068078
LRG display in Ensembl gene LRG_1021
NCBI gene (formerly Entrezgene) 2261
GeneCards 3690
HGNC Symbol HGNC:3690
MIM gene 134934
MIM morbid 616482
UniProtKB Gene Name Q96T34
WikiGene 2261
Gene: CHEK1
Ensembl ID : ENSG00000149554
Description: checkpoint kinase 1
Gene Synonyms: CHK1
10 APIs:
179 Possible Orthologues:

Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) R-HSA-5685942
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Regulation of TP53 Activity R-HSA-5633007
Signaling by SCF-KIT R-HSA-1433557
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G2/M Checkpoints R-HSA-69481
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
G1/S DNA Damage Checkpoints R-HSA-69615
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Homology Directed Repair R-HSA-5693538
DNA Repair R-HSA-73894
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Signal Transduction R-HSA-162582
Cell Cycle R-HSA-1640170
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of TP53 Activity R-HSA-5633007
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) R-HSA-5685942
G2/M DNA damage checkpoint R-HSA-69473
DNA Double-Strand Break Repair R-HSA-5693532
Processing of DNA double-strand break ends R-HSA-5693607
G2/M Checkpoints R-HSA-69481
Transcriptional Regulation by E2F6 R-HSA-8953750
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Homology Directed Repair R-HSA-5693538
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
p53-Independent DNA Damage Response R-HSA-69610
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
DNA Repair R-HSA-73894
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by SCF-KIT R-HSA-1433557
Activation of ATR in response to replication stress R-HSA-176187
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Gene expression (Transcription) R-HSA-74160
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
p53-Independent DNA Damage Response R-HSA-69610
Signaling by SCF-KIT R-HSA-1433557
G1/S DNA Damage Checkpoints R-HSA-69615
Processing of DNA double-strand break ends R-HSA-5693607
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Homology Directed Repair R-HSA-5693538
RNA Polymerase II Transcription R-HSA-73857
G2/M DNA damage checkpoint R-HSA-69473
HDR through Homologous Recombination (HRR) R-HSA-5685942
DNA Double-Strand Break Repair R-HSA-5693532
Signal Transduction R-HSA-162582
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M Checkpoints R-HSA-69481
DNA Repair R-HSA-73894
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Regulation of TP53 Activity R-HSA-5633007
Activation of ATR in response to replication stress R-HSA-176187
DNA Repair R-HSA-73894
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Activation of ATR in response to replication stress R-HSA-176187
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
HDR through Homologous Recombination (HRR) R-HSA-5685942
Homology Directed Repair R-HSA-5693538
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional Regulation by TP53 R-HSA-3700989
G2/M DNA damage checkpoint R-HSA-69473
DNA Double-Strand Break Repair R-HSA-5693532
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity R-HSA-5633007
Signaling by SCF-KIT R-HSA-1433557
G2/M Checkpoints R-HSA-69481
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Cell Cycle R-HSA-1640170
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle R-HSA-1640170
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Signal Transduction R-HSA-162582
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
G1/S DNA Damage Checkpoints R-HSA-69615
Cell Cycle Checkpoints R-HSA-69620
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
Homology Directed Repair R-HSA-5693538
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
Signaling by SCF-KIT R-HSA-1433557
Activation of ATR in response to replication stress R-HSA-176187
HDR through Homologous Recombination (HRR) R-HSA-5685942
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity R-HSA-5633007
Gene expression (Transcription) R-HSA-74160
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
G2/M Checkpoints R-HSA-69481
p53-Independent DNA Damage Response R-HSA-69610
Signal Transduction R-HSA-162582
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle R-HSA-1640170
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by SCF-KIT R-HSA-1433557
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Processing of DNA double-strand break ends R-HSA-5693607
DNA Repair R-HSA-73894
Activation of ATR in response to replication stress R-HSA-176187
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Generic Transcription Pathway R-HSA-212436
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) R-HSA-5685942
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G1/S DNA Damage Checkpoints R-HSA-69615
G2/M Checkpoints R-HSA-69481
Gene expression (Transcription) R-HSA-74160
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
Processing of DNA double-strand break ends R-HSA-5693607
Transcriptional Regulation by E2F6 R-HSA-8953750
DNA Repair R-HSA-73894
Cell Cycle Checkpoints R-HSA-69620
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
Generic Transcription Pathway R-HSA-212436
p53-Independent DNA Damage Response R-HSA-69610
HDR through Homologous Recombination (HRR) R-HSA-5685942
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
G1/S DNA Damage Checkpoints R-HSA-69615
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by TP53 R-HSA-3700989
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of TP53 Activity R-HSA-5633007
G2/M DNA damage checkpoint R-HSA-69473
Signaling by SCF-KIT R-HSA-1433557
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Homology Directed Repair R-HSA-5693538
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Cell Cycle R-HSA-1640170
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by SCF-KIT R-HSA-1433557
Transcriptional Regulation by TP53 R-HSA-3700989
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Transcriptional Regulation by E2F6 R-HSA-8953750
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Processing of DNA double-strand break ends R-HSA-5693607
Activation of ATR in response to replication stress R-HSA-176187
HDR through Homologous Recombination (HRR) R-HSA-5685942
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle Checkpoints R-HSA-69620
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of TP53 Activity R-HSA-5633007
DNA Repair R-HSA-73894
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
Generic Transcription Pathway R-HSA-212436
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
DNA Double-Strand Break Repair R-HSA-5693532
G1/S DNA Damage Checkpoints R-HSA-69615
Signal Transduction R-HSA-162582
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Gene expression (Transcription) R-HSA-74160
DNA Repair R-HSA-73894
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Signaling by SCF-KIT R-HSA-1433557
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
HDR through Homologous Recombination (HRR) R-HSA-5685942
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G2/M DNA damage checkpoint R-HSA-69473
Activation of ATR in response to replication stress R-HSA-176187
Regulation of TP53 Activity R-HSA-5633007
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
Homology Directed Repair R-HSA-5693538
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Transcriptional Regulation by E2F6 R-HSA-8953750
Processing of DNA double-strand break ends R-HSA-5693607
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
Generic Transcription Pathway R-HSA-212436
G1/S DNA Damage Checkpoints R-HSA-69615
DNA Double-Strand Break Repair R-HSA-5693532
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Cell Cycle Checkpoints R-HSA-69620
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Signal Transduction R-HSA-162582
Activation of ATR in response to replication stress R-HSA-176187
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of TP53 Activity R-HSA-5633007
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Signaling by SCF-KIT R-HSA-1433557
Transcriptional Regulation by TP53 R-HSA-3700989
Transcriptional Regulation by E2F6 R-HSA-8953750
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
DNA Repair R-HSA-73894
Processing of DNA double-strand break ends R-HSA-5693607
Homology Directed Repair R-HSA-5693538
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity R-HSA-5633007
Processing of DNA double-strand break ends R-HSA-5693607
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Cell Cycle Checkpoints R-HSA-69620
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Cell Cycle R-HSA-1640170
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Repair R-HSA-73894
G2/M DNA damage checkpoint R-HSA-69473
Signaling by SCF-KIT R-HSA-1433557
DNA Double-Strand Break Repair R-HSA-5693532
p53-Independent DNA Damage Response R-HSA-69610
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Transcriptional Regulation by E2F6 R-HSA-8953750
HDR through Homologous Recombination (HRR) R-HSA-5685942
Activation of ATR in response to replication stress R-HSA-176187
Signal Transduction R-HSA-162582
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Homology Directed Repair R-HSA-5693538
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
G1/S DNA Damage Checkpoints R-HSA-69615

Expression Atlas ENSG00000149554
NCBI gene (formerly Entrezgene) 1111
GeneCards 1925
HGNC Symbol HGNC:1925
MIM gene 603078
UniProtKB Gene Name O14757
WikiGene 1111
Gene: P2RX7
Ensembl ID : ENSG00000089041
Description: purinergic receptor P2X 7
Gene Synonyms: MGC20089,P2X7
4 APIs:
195 Possible Orthologues:

Purinergic signaling in leishmaniasis infection R-HSA-9660826
Infectious disease R-HSA-5663205
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Hemostasis R-HSA-109582
Inflammasomes R-HSA-622312
Immune System R-HSA-168256
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Elevation of cytosolic Ca2+ levels R-HSA-139853
Platelet homeostasis R-HSA-418346
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Innate Immune System R-HSA-168249
The NLRP3 inflammasome R-HSA-844456
Platelet calcium homeostasis R-HSA-418360
The NLRP3 inflammasome R-HSA-844456
Immune System R-HSA-168256
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Hemostasis R-HSA-109582
Platelet calcium homeostasis R-HSA-418360
Inflammasomes R-HSA-622312
Leishmania infection R-HSA-9658195
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Elevation of cytosolic Ca2+ levels R-HSA-139853
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Platelet homeostasis R-HSA-418346
Disease R-HSA-1643685
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet homeostasis R-HSA-418346
Immune System R-HSA-168256
Platelet calcium homeostasis R-HSA-418360
Cell recruitment (pro-inflammatory response) R-HSA-9664424
The NLRP3 inflammasome R-HSA-844456
Inflammasomes R-HSA-622312
Hemostasis R-HSA-109582
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Disease R-HSA-1643685
Elevation of cytosolic Ca2+ levels R-HSA-139853
Infectious disease R-HSA-5663205
Leishmania infection R-HSA-9658195
Innate Immune System R-HSA-168249
Elevation of cytosolic Ca2+ levels R-HSA-139853
Hemostasis R-HSA-109582
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Platelet homeostasis R-HSA-418346
Inflammasomes R-HSA-622312
The NLRP3 inflammasome R-HSA-844456
Infectious disease R-HSA-5663205
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Platelet calcium homeostasis R-HSA-418360
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Disease R-HSA-1643685
Immune System R-HSA-168256
Platelet calcium homeostasis R-HSA-418360
Infectious disease R-HSA-5663205
Elevation of cytosolic Ca2+ levels R-HSA-139853
Innate Immune System R-HSA-168249
Inflammasomes R-HSA-622312
Platelet homeostasis R-HSA-418346
The NLRP3 inflammasome R-HSA-844456
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Hemostasis R-HSA-109582
Leishmania infection R-HSA-9658195
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Inflammasomes R-HSA-622312
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Immune System R-HSA-168256
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Disease R-HSA-1643685
Elevation of cytosolic Ca2+ levels R-HSA-139853
Hemostasis R-HSA-109582
Platelet homeostasis R-HSA-418346
Purinergic signaling in leishmaniasis infection R-HSA-9660826
The NLRP3 inflammasome R-HSA-844456
Leishmania infection R-HSA-9658195
Platelet calcium homeostasis R-HSA-418360
Infectious disease R-HSA-5663205
Innate Immune System R-HSA-168249
Disease R-HSA-1643685
Inflammasomes R-HSA-622312
Immune System R-HSA-168256
Elevation of cytosolic Ca2+ levels R-HSA-139853
Innate Immune System R-HSA-168249
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Hemostasis R-HSA-109582
Leishmania infection R-HSA-9658195
Infectious disease R-HSA-5663205
The NLRP3 inflammasome R-HSA-844456
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Platelet homeostasis R-HSA-418346
Platelet calcium homeostasis R-HSA-418360
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Elevation of cytosolic Ca2+ levels R-HSA-139853
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Leishmania infection R-HSA-9658195
Infectious disease R-HSA-5663205
Innate Immune System R-HSA-168249
Inflammasomes R-HSA-622312
Disease R-HSA-1643685
Platelet calcium homeostasis R-HSA-418360
Platelet homeostasis R-HSA-418346
Immune System R-HSA-168256
Hemostasis R-HSA-109582
The NLRP3 inflammasome R-HSA-844456
Innate Immune System R-HSA-168249
Platelet calcium homeostasis R-HSA-418360
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Infectious disease R-HSA-5663205
Elevation of cytosolic Ca2+ levels R-HSA-139853
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Hemostasis R-HSA-109582
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Immune System R-HSA-168256
Inflammasomes R-HSA-622312
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Platelet homeostasis R-HSA-418346
The NLRP3 inflammasome R-HSA-844456
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Elevation of cytosolic Ca2+ levels R-HSA-139853
Platelet homeostasis R-HSA-418346
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet calcium homeostasis R-HSA-418360
Leishmania infection R-HSA-9658195
Inflammasomes R-HSA-622312
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Hemostasis R-HSA-109582
Disease R-HSA-1643685
The NLRP3 inflammasome R-HSA-844456
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Infectious disease R-HSA-5663205

Expression Atlas ENSG00000089041
NCBI gene (formerly Entrezgene) 5027
GeneCards 8537
HGNC Symbol HGNC:8537
MIM gene 602566
UniProtKB Gene Name Q99572
WikiGene 5027
Gene: HTR1D
Ensembl ID : ENSG00000179546
Description: 5-hydroxytryptamine receptor 1D
Gene Synonyms: 5-HT1D,HT1DA,HTRL,RDC4
17 APIs:
67 Possible Orthologues:

Amine ligand-binding receptors R-HSA-375280
Serotonin receptors R-HSA-390666
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
Amine ligand-binding receptors R-HSA-375280
Serotonin receptors R-HSA-390666
GPCR ligand binding R-HSA-500792
G alpha (i) signalling events R-HSA-418594
Amine ligand-binding receptors R-HSA-375280
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Serotonin receptors R-HSA-390666
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Amine ligand-binding receptors R-HSA-375280
G alpha (i) signalling events R-HSA-418594
Serotonin receptors R-HSA-390666
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
Serotonin receptors R-HSA-390666
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Amine ligand-binding receptors R-HSA-375280
Amine ligand-binding receptors R-HSA-375280
GPCR downstream signalling R-HSA-388396
G alpha (i) signalling events R-HSA-418594
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Serotonin receptors R-HSA-390666
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790

Expression Atlas ENSG00000179546
NCBI gene (formerly Entrezgene) 3352
GeneCards 5289
HGNC Symbol HGNC:5289
MIM gene 182133
UniProtKB Gene Name P28221
WikiGene 3352
Gene: CHRNB2
Ensembl ID : ENSG00000160716
Description: cholinergic receptor nicotinic beta 2 subunit
Gene Synonyms:
14 APIs:
198 Possible Orthologues:

Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Acetylcholine binding and downstream events R-HSA-181431
Transmission across Chemical Synapses R-HSA-112315
Neuronal System R-HSA-112316
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Transmission across Chemical Synapses R-HSA-112315
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Neuronal System R-HSA-112316
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Acetylcholine binding and downstream events R-HSA-181431
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Neuronal System R-HSA-112316
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Acetylcholine binding and downstream events R-HSA-181431
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Transmission across Chemical Synapses R-HSA-112315
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Transmission across Chemical Synapses R-HSA-112315
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Acetylcholine binding and downstream events R-HSA-181431
Neuronal System R-HSA-112316
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Neuronal System R-HSA-112316
Transmission across Chemical Synapses R-HSA-112315
Acetylcholine binding and downstream events R-HSA-181431
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Neuronal System R-HSA-112316
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Transmission across Chemical Synapses R-HSA-112315
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Acetylcholine binding and downstream events R-HSA-181431
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Neuronal System R-HSA-112316
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Transmission across Chemical Synapses R-HSA-112315
Acetylcholine binding and downstream events R-HSA-181431
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Transmission across Chemical Synapses R-HSA-112315
Acetylcholine binding and downstream events R-HSA-181431
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Neuronal System R-HSA-112316
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Neuronal System R-HSA-112316
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Acetylcholine binding and downstream events R-HSA-181431
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Transmission across Chemical Synapses R-HSA-112315
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors R-HSA-629587
Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597
Acetylcholine binding and downstream events R-HSA-181431
Presynaptic nicotinic acetylcholine receptors R-HSA-622323
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594
Transmission across Chemical Synapses R-HSA-112315
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Neuronal System R-HSA-112316
Postsynaptic nicotinic acetylcholine receptors R-HSA-622327

Expression Atlas ENSG00000160716
NCBI gene (formerly Entrezgene) 1141
GeneCards 1962
HGNC Symbol HGNC:1962
MIM gene 118507
MIM morbid 605375
UniProtKB Gene Name Q5SXY3
WikiGene 1141
Gene: GRIN2D
Ensembl ID : ENSG00000105464
Description: glutamate ionotropic receptor NMDA type subunit 2D
Gene Synonyms: EB11,GLUN2D,NMDAR2D,NR2D
20 APIs:
280 Possible Orthologues:

Transmission across Chemical Synapses R-HSA-112315
Neuronal System R-HSA-112316
Synaptic adhesion-like molecules R-HSA-8849932
Protein-protein interactions at synapses R-HSA-6794362
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signal Transduction R-HSA-162582
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Long-term potentiation R-HSA-9620244
MAPK1/MAPK3 signaling R-HSA-5684996
Post NMDA receptor activation events R-HSA-438064
MAPK family signaling cascades R-HSA-5683057
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
RAF/MAP kinase cascade R-HSA-5673001
Neurexins and neuroligins R-HSA-6794361
Neuronal System R-HSA-112316
MAPK family signaling cascades R-HSA-5683057
Neurexins and neuroligins R-HSA-6794361
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Post NMDA receptor activation events R-HSA-438064
Transmission across Chemical Synapses R-HSA-112315
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signal Transduction R-HSA-162582
Protein-protein interactions at synapses R-HSA-6794362
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Long-term potentiation R-HSA-9620244
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
RAF/MAP kinase cascade R-HSA-5673001
Synaptic adhesion-like molecules R-HSA-8849932
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
MAPK1/MAPK3 signaling R-HSA-5684996
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Post NMDA receptor activation events R-HSA-438064
Synaptic adhesion-like molecules R-HSA-8849932
Protein-protein interactions at synapses R-HSA-6794362
Signal Transduction R-HSA-162582
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
MAPK1/MAPK3 signaling R-HSA-5684996
Transmission across Chemical Synapses R-HSA-112315
RAF/MAP kinase cascade R-HSA-5673001
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Long-term potentiation R-HSA-9620244
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Neuronal System R-HSA-112316
Activation of NMDA receptors and postsynaptic events R-HSA-442755
MAPK family signaling cascades R-HSA-5683057
Neurexins and neuroligins R-HSA-6794361
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Protein-protein interactions at synapses R-HSA-6794362
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Neurexins and neuroligins R-HSA-6794361
MAPK1/MAPK3 signaling R-HSA-5684996
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
Post NMDA receptor activation events R-HSA-438064
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Long-term potentiation R-HSA-9620244
Neuronal System R-HSA-112316
MAPK family signaling cascades R-HSA-5683057
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Transmission across Chemical Synapses R-HSA-112315
Synaptic adhesion-like molecules R-HSA-8849932
Transmission across Chemical Synapses R-HSA-112315
Post NMDA receptor activation events R-HSA-438064
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
MAPK1/MAPK3 signaling R-HSA-5684996
Neuronal System R-HSA-112316
Synaptic adhesion-like molecules R-HSA-8849932
Protein-protein interactions at synapses R-HSA-6794362
Long-term potentiation R-HSA-9620244
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
MAPK family signaling cascades R-HSA-5683057
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Neurexins and neuroligins R-HSA-6794361
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Neurexins and neuroligins R-HSA-6794361
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
RAF/MAP kinase cascade R-HSA-5673001
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
MAPK1/MAPK3 signaling R-HSA-5684996
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Synaptic adhesion-like molecules R-HSA-8849932
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Neuronal System R-HSA-112316
Post NMDA receptor activation events R-HSA-438064
Signal Transduction R-HSA-162582
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
MAPK family signaling cascades R-HSA-5683057
Transmission across Chemical Synapses R-HSA-112315
Protein-protein interactions at synapses R-HSA-6794362
Long-term potentiation R-HSA-9620244
Post NMDA receptor activation events R-HSA-438064
Neurexins and neuroligins R-HSA-6794361
Protein-protein interactions at synapses R-HSA-6794362
Neuronal System R-HSA-112316
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Transmission across Chemical Synapses R-HSA-112315
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Synaptic adhesion-like molecules R-HSA-8849932
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Long-term potentiation R-HSA-9620244
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
Signal Transduction R-HSA-162582
RAF/MAP kinase cascade R-HSA-5673001
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Activation of NMDA receptors and postsynaptic events R-HSA-442755
MAPK1/MAPK3 signaling R-HSA-5684996
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signal Transduction R-HSA-162582
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Neurexins and neuroligins R-HSA-6794361
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Transmission across Chemical Synapses R-HSA-112315
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
Post NMDA receptor activation events R-HSA-438064
Protein-protein interactions at synapses R-HSA-6794362
Neuronal System R-HSA-112316
Long-term potentiation R-HSA-9620244
RAF/MAP kinase cascade R-HSA-5673001
MAPK family signaling cascades R-HSA-5683057
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Synaptic adhesion-like molecules R-HSA-8849932
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
MAPK1/MAPK3 signaling R-HSA-5684996
Neuronal System R-HSA-112316
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Protein-protein interactions at synapses R-HSA-6794362
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
Post NMDA receptor activation events R-HSA-438064
Synaptic adhesion-like molecules R-HSA-8849932
Signal Transduction R-HSA-162582
Long-term potentiation R-HSA-9620244
Neurexins and neuroligins R-HSA-6794361
Transmission across Chemical Synapses R-HSA-112315
Activation of NMDA receptors and postsynaptic events R-HSA-442755
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
Unblocking of NMDA receptors, glutamate binding and activation R-HSA-438066
Protein-protein interactions at synapses R-HSA-6794362
MAPK family signaling cascades R-HSA-5683057
Assembly and cell surface presentation of NMDA receptors R-HSA-9609736
RAF/MAP kinase cascade R-HSA-5673001
Post NMDA receptor activation events R-HSA-438064
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Neuronal System R-HSA-112316
MAPK1/MAPK3 signaling R-HSA-5684996
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Long-term potentiation R-HSA-9620244
Synaptic adhesion-like molecules R-HSA-8849932
Signal Transduction R-HSA-162582
Transmission across Chemical Synapses R-HSA-112315
Negative regulation of NMDA receptor-mediated neuronal transmission R-HSA-9617324
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Neurexins and neuroligins R-HSA-6794361

Expression Atlas ENSG00000105464
NCBI gene (formerly Entrezgene) 2906
GeneCards 4588
HGNC Symbol HGNC:4588
MIM gene 602717
MIM morbid 617162
UniProtKB Gene Name O15399
WikiGene 2906