Gene: PLK4
Ensembl ID : ENSG00000142731
Description: polo like kinase 4
Gene Synonyms: SAK,STK18
2 APIs:
215 Possible Orthologues:

G2/M Transition R-HSA-69275
Cilium Assembly R-HSA-5617833
Loss of Nlp from mitotic centrosomes R-HSA-380259
Centrosome maturation R-HSA-380287
Cell Cycle R-HSA-1640170
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Organelle biogenesis and maintenance R-HSA-1852241
Mitotic G2-G2/M phases R-HSA-453274
Cell Cycle, Mitotic R-HSA-69278
M Phase R-HSA-68886
AURKA Activation by TPX2 R-HSA-8854518
Mitotic Prometaphase R-HSA-68877
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
M Phase R-HSA-68886
Cilium Assembly R-HSA-5617833
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Centrosome maturation R-HSA-380287
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Mitotic Prometaphase R-HSA-68877
Mitotic G2-G2/M phases R-HSA-453274
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
AURKA Activation by TPX2 R-HSA-8854518
Cell Cycle R-HSA-1640170
Loss of Nlp from mitotic centrosomes R-HSA-380259
Organelle biogenesis and maintenance R-HSA-1852241
G2/M Transition R-HSA-69275
Cell Cycle, Mitotic R-HSA-69278
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
G2/M Transition R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Cell Cycle R-HSA-1640170
Centrosome maturation R-HSA-380287
Cell Cycle, Mitotic R-HSA-69278
AURKA Activation by TPX2 R-HSA-8854518
Organelle biogenesis and maintenance R-HSA-1852241
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Mitotic G2-G2/M phases R-HSA-453274
Mitotic Prometaphase R-HSA-68877
Cilium Assembly R-HSA-5617833
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
M Phase R-HSA-68886
Loss of Nlp from mitotic centrosomes R-HSA-380259
Organelle biogenesis and maintenance R-HSA-1852241
Cell Cycle R-HSA-1640170
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Cell Cycle, Mitotic R-HSA-69278
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Cilium Assembly R-HSA-5617833
Loss of Nlp from mitotic centrosomes R-HSA-380259
Mitotic G2-G2/M phases R-HSA-453274
AURKA Activation by TPX2 R-HSA-8854518
Centrosome maturation R-HSA-380287
M Phase R-HSA-68886
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
G2/M Transition R-HSA-69275
Mitotic Prometaphase R-HSA-68877
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Mitotic Prometaphase R-HSA-68877
Loss of Nlp from mitotic centrosomes R-HSA-380259
Cell Cycle, Mitotic R-HSA-69278
Organelle biogenesis and maintenance R-HSA-1852241
M Phase R-HSA-68886
Cilium Assembly R-HSA-5617833
Centrosome maturation R-HSA-380287
G2/M Transition R-HSA-69275
AURKA Activation by TPX2 R-HSA-8854518
Mitotic G2-G2/M phases R-HSA-453274
Cell Cycle R-HSA-1640170
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Mitotic G2-G2/M phases R-HSA-453274
Mitotic Prometaphase R-HSA-68877
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Centrosome maturation R-HSA-380287
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
M Phase R-HSA-68886
AURKA Activation by TPX2 R-HSA-8854518
Loss of Nlp from mitotic centrosomes R-HSA-380259
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Organelle biogenesis and maintenance R-HSA-1852241
Cell Cycle R-HSA-1640170
Cilium Assembly R-HSA-5617833
G2/M Transition R-HSA-69275
Cell Cycle, Mitotic R-HSA-69278
Organelle biogenesis and maintenance R-HSA-1852241
Cilium Assembly R-HSA-5617833
Mitotic Prometaphase R-HSA-68877
Cell Cycle R-HSA-1640170
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
M Phase R-HSA-68886
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Cell Cycle, Mitotic R-HSA-69278
G2/M Transition R-HSA-69275
AURKA Activation by TPX2 R-HSA-8854518
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Loss of Nlp from mitotic centrosomes R-HSA-380259
Centrosome maturation R-HSA-380287
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Mitotic G2-G2/M phases R-HSA-453274
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
G2/M Transition R-HSA-69275
AURKA Activation by TPX2 R-HSA-8854518
Loss of Nlp from mitotic centrosomes R-HSA-380259
Cell Cycle, Mitotic R-HSA-69278
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Cilium Assembly R-HSA-5617833
Mitotic Prometaphase R-HSA-68877
Organelle biogenesis and maintenance R-HSA-1852241
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Centrosome maturation R-HSA-380287
Mitotic G2-G2/M phases R-HSA-453274
M Phase R-HSA-68886
Cell Cycle R-HSA-1640170
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Cilium Assembly R-HSA-5617833
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Mitotic G2-G2/M phases R-HSA-453274
Cell Cycle, Mitotic R-HSA-69278
Mitotic Prometaphase R-HSA-68877
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Cell Cycle R-HSA-1640170
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
M Phase R-HSA-68886
G2/M Transition R-HSA-69275
Loss of Nlp from mitotic centrosomes R-HSA-380259
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
AURKA Activation by TPX2 R-HSA-8854518
Organelle biogenesis and maintenance R-HSA-1852241
Centrosome maturation R-HSA-380287
G2/M Transition R-HSA-69275
Anchoring of the basal body to the plasma membrane R-HSA-5620912
Mitotic Prometaphase R-HSA-68877
Cell Cycle, Mitotic R-HSA-69278
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
Loss of Nlp from mitotic centrosomes R-HSA-380259
Mitotic G2-G2/M phases R-HSA-453274
Centrosome maturation R-HSA-380287
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Organelle biogenesis and maintenance R-HSA-1852241
Cilium Assembly R-HSA-5617833
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Cell Cycle R-HSA-1640170
M Phase R-HSA-68886
AURKA Activation by TPX2 R-HSA-8854518
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Anchoring of the basal body to the plasma membrane R-HSA-5620912
AURKA Activation by TPX2 R-HSA-8854518
Cell Cycle, Mitotic R-HSA-69278
Centrosome maturation R-HSA-380287
Organelle biogenesis and maintenance R-HSA-1852241
Loss of Nlp from mitotic centrosomes R-HSA-380259
Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380284
M Phase R-HSA-68886
Cilium Assembly R-HSA-5617833
Mitotic Prometaphase R-HSA-68877
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Cell Cycle R-HSA-1640170
Recruitment of mitotic centrosome proteins and complexes R-HSA-380270
Recruitment of NuMA to mitotic centrosomes R-HSA-380320
Mitotic G2-G2/M phases R-HSA-453274
G2/M Transition R-HSA-69275

Expression Atlas ENSG00000142731
NCBI gene (formerly Entrezgene) 10733
GeneCards 11397
HGNC Symbol HGNC:11397
MIM gene 605031
MIM morbid 616171
UniProtKB Gene Name O00444
WikiGene 10733
Gene: PRKD3
Ensembl ID : ENSG00000115825
Description: protein kinase D3
Gene Synonyms: EPK2,PRKCN
5 APIs:
274 Possible Orthologues:

Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism of lipids R-HSA-556833
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism of lipids R-HSA-556833
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Metabolism R-HSA-1430728
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661
Sphingolipid metabolism R-HSA-428157
Sphingolipid metabolism R-HSA-428157
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Sphingolipid de novo biosynthesis R-HSA-1660661

Expression Atlas ENSG00000115825
NCBI gene (formerly Entrezgene) 23683
GeneCards 9408
HGNC Symbol HGNC:9408
MIM gene 607077
UniProtKB Gene Name O94806
WikiGene 23683
Gene: NPM1
Ensembl ID : ENSG00000181163
Description: nucleophosmin 1
Gene Synonyms: B23,NPM
2 APIs:
158 Possible Orthologues:

Chromosome Maintenance R-HSA-73886
SARS-CoV-1 Infection R-HSA-9678108
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Nucleosome assembly R-HSA-774815
Interactions of Rev with host cellular proteins R-HSA-177243
Post-translational protein modification R-HSA-597592
RNA Polymerase II Transcription R-HSA-73857
ALK mutants bind TKIs R-HSA-9700645
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle R-HSA-1640170
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
Infectious disease R-HSA-5663205
Generic Transcription Pathway R-HSA-212436
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SARS-CoV-1-host interactions R-HSA-9692914
HIV Infection R-HSA-162906
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Host Interactions of HIV factors R-HSA-162909
SUMOylation R-HSA-2990846
Metabolism of proteins R-HSA-392499
SUMOylation of transcription cofactors R-HSA-3899300
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK in cancer R-HSA-9700206
Gene expression (Transcription) R-HSA-74160
SARS-CoV Infections R-HSA-9679506
Nuclear import of Rev protein R-HSA-180746
RNA Polymerase II Transcription R-HSA-73857
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
SARS-CoV-1-host interactions R-HSA-9692914
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle R-HSA-1640170
Interactions of Rev with host cellular proteins R-HSA-177243
HIV Infection R-HSA-162906
SARS-CoV-1 Infection R-HSA-9678108
Chromosome Maintenance R-HSA-73886
Nucleosome assembly R-HSA-774815
Nuclear import of Rev protein R-HSA-180746
SUMOylation of transcription cofactors R-HSA-3899300
Disease R-HSA-1643685
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Generic Transcription Pathway R-HSA-212436
Signaling by ALK in cancer R-HSA-9700206
Host Interactions of HIV factors R-HSA-162909
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Post-translational protein modification R-HSA-597592
SUMOylation R-HSA-2990846
Infectious disease R-HSA-5663205
Metabolism of proteins R-HSA-392499
ALK mutants bind TKIs R-HSA-9700645
SARS-CoV Infections R-HSA-9679506
Gene expression (Transcription) R-HSA-74160
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
SUMOylation of transcription cofactors R-HSA-3899300
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Generic Transcription Pathway R-HSA-212436
SARS-CoV Infections R-HSA-9679506
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK in cancer R-HSA-9700206
Host Interactions of HIV factors R-HSA-162909
Post-translational protein modification R-HSA-597592
Chromosome Maintenance R-HSA-73886
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
HIV Infection R-HSA-162906
SUMOylation R-HSA-2990846
SARS-CoV-1 Infection R-HSA-9678108
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
Nucleosome assembly R-HSA-774815
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Gene expression (Transcription) R-HSA-74160
Metabolism of proteins R-HSA-392499
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Signaling by ALK fusions and activated point mutants R-HSA-9725370
SARS-CoV-1-host interactions R-HSA-9692914
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Cell Cycle R-HSA-1640170
ALK mutants bind TKIs R-HSA-9700645
Nuclear import of Rev protein R-HSA-180746
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Transcriptional Regulation by TP53 R-HSA-3700989
Interactions of Rev with host cellular proteins R-HSA-177243
Cell Cycle R-HSA-1640170
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interactions of Rev with host cellular proteins R-HSA-177243
Host Interactions of HIV factors R-HSA-162909
SARS-CoV-1 Infection R-HSA-9678108
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
Signaling by ALK in cancer R-HSA-9700206
Metabolism of proteins R-HSA-392499
Nuclear import of Rev protein R-HSA-180746
RNA Polymerase II Transcription R-HSA-73857
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Nucleosome assembly R-HSA-774815
Generic Transcription Pathway R-HSA-212436
ALK mutants bind TKIs R-HSA-9700645
Post-translational protein modification R-HSA-597592
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Infectious disease R-HSA-5663205
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
SUMOylation R-HSA-2990846
SUMOylation of transcription cofactors R-HSA-3899300
Chromosome Maintenance R-HSA-73886
Gene expression (Transcription) R-HSA-74160
SARS-CoV-1-host interactions R-HSA-9692914
SARS-CoV Infections R-HSA-9679506
Transcriptional Regulation by TP53 R-HSA-3700989
HIV Infection R-HSA-162906
SARS-CoV-1-host interactions R-HSA-9692914
Generic Transcription Pathway R-HSA-212436
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Interactions of Rev with host cellular proteins R-HSA-177243
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Metabolism of proteins R-HSA-392499
SUMOylation R-HSA-2990846
Cell Cycle R-HSA-1640170
Signaling by ALK in cancer R-HSA-9700206
ALK mutants bind TKIs R-HSA-9700645
SUMOylation of transcription cofactors R-HSA-3899300
Infectious disease R-HSA-5663205
Disease R-HSA-1643685
Chromosome Maintenance R-HSA-73886
Nuclear import of Rev protein R-HSA-180746
SARS-CoV-1 Infection R-HSA-9678108
HIV Infection R-HSA-162906
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-6804115
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Transcriptional Regulation by TP53 R-HSA-3700989
RNA Polymerase II Transcription R-HSA-73857
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Gene expression (Transcription) R-HSA-74160
Post-translational protein modification R-HSA-597592
Host Interactions of HIV factors R-HSA-162909
SARS-CoV Infections R-HSA-9679506
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8869496
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279
Nucleosome assembly R-HSA-774815

Expression Atlas ENSG00000181163
LRG display in Ensembl gene LRG_458
NCBI gene (formerly Entrezgene) 4869
GeneCards 7910
HGNC Symbol HGNC:7910
MIM gene 164040
MIM morbid 601626
UniProtKB Gene Name P06748
WikiGene 4869
Gene: ALK
Ensembl ID : ENSG00000171094
Description: ALK receptor tyrosine kinase
Gene Synonyms: ALK1,CD246
11 APIs:
195 Possible Orthologues:

ALK mutants bind TKIs R-HSA-9700645
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK R-HSA-201556
ceritinib-resistant ALK mutants R-HSA-9717323
crizotinib-resistant ALK mutants R-HSA-9717326
Signal Transduction R-HSA-162582
ASP-3026-resistant ALK mutants R-HSA-9717264
lorlatinib-resistant ALK mutants R-HSA-9717329
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
Disease R-HSA-1643685
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NVP-TAE684-resistant ALK mutants R-HSA-9717301
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK in cancer R-HSA-9700206
alectinib-resistant ALK mutants R-HSA-9717316
brigatinib-resistant ALK mutants R-HSA-9717319
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK in cancer R-HSA-9700206
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Disease R-HSA-1643685
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by ALK fusions and activated point mutants R-HSA-9725370
ASP-3026-resistant ALK mutants R-HSA-9717264
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK R-HSA-201556
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
brigatinib-resistant ALK mutants R-HSA-9717319
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ALK R-HSA-201556
crizotinib-resistant ALK mutants R-HSA-9717326
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
ASP-3026-resistant ALK mutants R-HSA-9717264
Drug resistance of ALK mutants R-HSA-9700649
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by ALK in cancer R-HSA-9700206
NVP-TAE684-resistant ALK mutants R-HSA-9717301
lorlatinib-resistant ALK mutants R-HSA-9717329
Signal Transduction R-HSA-162582
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
ALK mutants bind TKIs R-HSA-9700645
ASP-3026-resistant ALK mutants R-HSA-9717264
Disease R-HSA-1643685
brigatinib-resistant ALK mutants R-HSA-9717319
alectinib-resistant ALK mutants R-HSA-9717316
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ALK in cancer R-HSA-9700206
Drug resistance of ALK mutants R-HSA-9700649
Signal Transduction R-HSA-162582
NVP-TAE684-resistant ALK mutants R-HSA-9717301
ceritinib-resistant ALK mutants R-HSA-9717323
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK fusions and activated point mutants R-HSA-9725370
lorlatinib-resistant ALK mutants R-HSA-9717329
Signaling by ALK R-HSA-201556
brigatinib-resistant ALK mutants R-HSA-9717319
ceritinib-resistant ALK mutants R-HSA-9717323
Signal Transduction R-HSA-162582
Signaling by ALK fusions and activated point mutants R-HSA-9725370
lorlatinib-resistant ALK mutants R-HSA-9717329
Drug resistance of ALK mutants R-HSA-9700649
alectinib-resistant ALK mutants R-HSA-9717316
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by ALK R-HSA-201556
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ASP-3026-resistant ALK mutants R-HSA-9717264
Signaling by ALK in cancer R-HSA-9700206
crizotinib-resistant ALK mutants R-HSA-9717326
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
ALK mutants bind TKIs R-HSA-9700645
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Disease R-HSA-1643685
Signaling by ALK in cancer R-HSA-9700206
NVP-TAE684-resistant ALK mutants R-HSA-9717301
lorlatinib-resistant ALK mutants R-HSA-9717329
ASP-3026-resistant ALK mutants R-HSA-9717264
ceritinib-resistant ALK mutants R-HSA-9717323
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
brigatinib-resistant ALK mutants R-HSA-9717319
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
alectinib-resistant ALK mutants R-HSA-9717316
crizotinib-resistant ALK mutants R-HSA-9717326
Signaling by ALK R-HSA-201556
Signal Transduction R-HSA-162582
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK R-HSA-201556
ceritinib-resistant ALK mutants R-HSA-9717323
ASP-3026-resistant ALK mutants R-HSA-9717264
brigatinib-resistant ALK mutants R-HSA-9717319
ALK mutants bind TKIs R-HSA-9700645
Signaling by ALK in cancer R-HSA-9700206
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
crizotinib-resistant ALK mutants R-HSA-9717326
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Drug resistance of ALK mutants R-HSA-9700649
lorlatinib-resistant ALK mutants R-HSA-9717329
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signal Transduction R-HSA-162582
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
alectinib-resistant ALK mutants R-HSA-9717316
Disease R-HSA-1643685
Signaling by ALK R-HSA-201556
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ALK mutants bind TKIs R-HSA-9700645
Drug resistance of ALK mutants R-HSA-9700649
crizotinib-resistant ALK mutants R-HSA-9717326
ceritinib-resistant ALK mutants R-HSA-9717323
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Signaling by ALK in cancer R-HSA-9700206
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
ASP-3026-resistant ALK mutants R-HSA-9717264
alectinib-resistant ALK mutants R-HSA-9717316
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ALK R-HSA-201556
NVP-TAE684-resistant ALK mutants R-HSA-9717301
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Disease R-HSA-1643685
ALK mutants bind TKIs R-HSA-9700645
crizotinib-resistant ALK mutants R-HSA-9717326
Drug resistance of ALK mutants R-HSA-9700649
lorlatinib-resistant ALK mutants R-HSA-9717329
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Signaling by ALK in cancer R-HSA-9700206
ASP-3026-resistant ALK mutants R-HSA-9717264
alectinib-resistant ALK mutants R-HSA-9717316
ceritinib-resistant ALK mutants R-HSA-9717323
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
brigatinib-resistant ALK mutants R-HSA-9717319
alectinib-resistant ALK mutants R-HSA-9717316
Signaling by ALK in cancer R-HSA-9700206
ASP-3026-resistant ALK mutants R-HSA-9717264
Signal Transduction R-HSA-162582
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Drug resistance of ALK mutants R-HSA-9700649
Signaling by ALK R-HSA-201556
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ceritinib-resistant ALK mutants R-HSA-9717323
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
ALK mutants bind TKIs R-HSA-9700645
lorlatinib-resistant ALK mutants R-HSA-9717329
NVP-TAE684-resistant ALK mutants R-HSA-9717301
crizotinib-resistant ALK mutants R-HSA-9717326
brigatinib-resistant ALK mutants R-HSA-9717319

Expression Atlas ENSG00000171094
LRG display in Ensembl gene LRG_488
NCBI gene (formerly Entrezgene) 238
GeneCards 427
HGNC Symbol HGNC:427
MIM gene 105590
MIM morbid 613014
UniProtKB Gene Name Q9UM73
WikiGene 238
Gene: CDC7
Ensembl ID : ENSG00000097046
Description: cell division cycle 7
Gene Synonyms: CDC7L1,HSCDC7,HSK1,HUCDC7
4 APIs:
209 Possible Orthologues:

DNA Replication R-HSA-69306
Mitotic G1 phase and G1/S transition R-HSA-453279
Activation of the pre-replicative complex R-HSA-68962
DNA Replication Pre-Initiation R-HSA-69002
RNA Polymerase II Transcription R-HSA-73857
Activation of ATR in response to replication stress R-HSA-176187
Transcriptional Regulation by E2F6 R-HSA-8953750
G1/S Transition R-HSA-69206
Cell Cycle R-HSA-1640170
G2/M Checkpoints R-HSA-69481
Gene expression (Transcription) R-HSA-74160
Cell Cycle Checkpoints R-HSA-69620
Cell Cycle, Mitotic R-HSA-69278
Generic Transcription Pathway R-HSA-212436
DNA Replication R-HSA-69306
G2/M Checkpoints R-HSA-69481
Mitotic G1 phase and G1/S transition R-HSA-453279
Activation of ATR in response to replication stress R-HSA-176187
Cell Cycle R-HSA-1640170
Generic Transcription Pathway R-HSA-212436
Gene expression (Transcription) R-HSA-74160
Activation of the pre-replicative complex R-HSA-68962
Cell Cycle, Mitotic R-HSA-69278
Transcriptional Regulation by E2F6 R-HSA-8953750
DNA Replication Pre-Initiation R-HSA-69002
Cell Cycle Checkpoints R-HSA-69620
RNA Polymerase II Transcription R-HSA-73857
G1/S Transition R-HSA-69206
Generic Transcription Pathway R-HSA-212436
Activation of the pre-replicative complex R-HSA-68962
DNA Replication Pre-Initiation R-HSA-69002
Cell Cycle R-HSA-1640170
Activation of ATR in response to replication stress R-HSA-176187
Cell Cycle, Mitotic R-HSA-69278
G2/M Checkpoints R-HSA-69481
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle Checkpoints R-HSA-69620
G1/S Transition R-HSA-69206
DNA Replication R-HSA-69306
Transcriptional Regulation by E2F6 R-HSA-8953750
G1/S Transition R-HSA-69206
Cell Cycle R-HSA-1640170
Activation of ATR in response to replication stress R-HSA-176187
Mitotic G1 phase and G1/S transition R-HSA-453279
DNA Replication Pre-Initiation R-HSA-69002
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Gene expression (Transcription) R-HSA-74160
DNA Replication R-HSA-69306
Activation of the pre-replicative complex R-HSA-68962
Cell Cycle, Mitotic R-HSA-69278
G2/M Checkpoints R-HSA-69481
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle Checkpoints R-HSA-69620
DNA Replication R-HSA-69306
DNA Replication Pre-Initiation R-HSA-69002
Gene expression (Transcription) R-HSA-74160
G1/S Transition R-HSA-69206
G2/M Checkpoints R-HSA-69481
Cell Cycle R-HSA-1640170
Transcriptional Regulation by E2F6 R-HSA-8953750
Cell Cycle Checkpoints R-HSA-69620
Mitotic G1 phase and G1/S transition R-HSA-453279
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Activation of the pre-replicative complex R-HSA-68962
Activation of ATR in response to replication stress R-HSA-176187
Cell Cycle, Mitotic R-HSA-69278
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Activation of the pre-replicative complex R-HSA-68962
DNA Replication Pre-Initiation R-HSA-69002
Cell Cycle Checkpoints R-HSA-69620
G2/M Checkpoints R-HSA-69481
Activation of ATR in response to replication stress R-HSA-176187
DNA Replication R-HSA-69306
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle R-HSA-1640170
Transcriptional Regulation by E2F6 R-HSA-8953750
Gene expression (Transcription) R-HSA-74160
G1/S Transition R-HSA-69206
Cell Cycle, Mitotic R-HSA-69278
Mitotic G1 phase and G1/S transition R-HSA-453279
Generic Transcription Pathway R-HSA-212436
DNA Replication R-HSA-69306
Activation of the pre-replicative complex R-HSA-68962
G2/M Checkpoints R-HSA-69481
DNA Replication Pre-Initiation R-HSA-69002
Activation of ATR in response to replication stress R-HSA-176187
G1/S Transition R-HSA-69206
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by E2F6 R-HSA-8953750
Gene expression (Transcription) R-HSA-74160
Cell Cycle Checkpoints R-HSA-69620
G2/M Checkpoints R-HSA-69481
Transcriptional Regulation by E2F6 R-HSA-8953750
Activation of ATR in response to replication stress R-HSA-176187
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
DNA Replication R-HSA-69306
Cell Cycle Checkpoints R-HSA-69620
G1/S Transition R-HSA-69206
Cell Cycle, Mitotic R-HSA-69278
Activation of the pre-replicative complex R-HSA-68962
DNA Replication Pre-Initiation R-HSA-69002
Cell Cycle R-HSA-1640170
Gene expression (Transcription) R-HSA-74160
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle, Mitotic R-HSA-69278
Activation of ATR in response to replication stress R-HSA-176187
DNA Replication R-HSA-69306
Activation of the pre-replicative complex R-HSA-68962
Cell Cycle Checkpoints R-HSA-69620
RNA Polymerase II Transcription R-HSA-73857
G2/M Checkpoints R-HSA-69481
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle R-HSA-1640170
DNA Replication Pre-Initiation R-HSA-69002
Transcriptional Regulation by E2F6 R-HSA-8953750
Generic Transcription Pathway R-HSA-212436
Gene expression (Transcription) R-HSA-74160
G1/S Transition R-HSA-69206
Cell Cycle R-HSA-1640170
DNA Replication R-HSA-69306
DNA Replication Pre-Initiation R-HSA-69002
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by E2F6 R-HSA-8953750
Activation of the pre-replicative complex R-HSA-68962
G1/S Transition R-HSA-69206
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
Gene expression (Transcription) R-HSA-74160
Cell Cycle, Mitotic R-HSA-69278
G2/M Checkpoints R-HSA-69481
Activation of ATR in response to replication stress R-HSA-176187
Mitotic G1 phase and G1/S transition R-HSA-453279
G1/S Transition R-HSA-69206
Transcriptional Regulation by E2F6 R-HSA-8953750
DNA Replication R-HSA-69306
DNA Replication Pre-Initiation R-HSA-69002
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle Checkpoints R-HSA-69620
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
Activation of ATR in response to replication stress R-HSA-176187
Activation of the pre-replicative complex R-HSA-68962
G2/M Checkpoints R-HSA-69481
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160

Expression Atlas ENSG00000097046
NCBI gene (formerly Entrezgene) 8317
GeneCards 1745
HGNC Symbol HGNC:1745
MIM gene 603311
UniProtKB Gene Name O00311
WikiGene 8317
Gene: MAP3K11
Ensembl ID : ENSG00000173327
Description: mitogen-activated protein kinase kinase kinase 11
Gene Synonyms: MEKK11,MLK3,PTK1,SPRK
1 APIs:
184 Possible Orthologues:

RAF activation R-HSA-5673000
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOV GTPase cycle R-HSA-9013424
RAF/MAP kinase cascade R-HSA-5673001
Oncogenic MAPK signaling R-HSA-6802957
Signal Transduction R-HSA-162582
Signaling by Rho GTPases R-HSA-194315
RHO GTPase cycle R-HSA-9012999
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RHOG GTPase cycle R-HSA-9013408
MAPK family signaling cascades R-HSA-5683057
CDC42 GTPase cycle R-HSA-9013148
Signaling downstream of RAS mutants R-HSA-9649948
RAF activation R-HSA-5673000
MAPK1/MAPK3 signaling R-HSA-5684996
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOV GTPase cycle R-HSA-9013424
MAPK family signaling cascades R-HSA-5683057
Signaling by RAS mutants R-HSA-6802949
RAF/MAP kinase cascade R-HSA-5673001
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
CDC42 GTPase cycle R-HSA-9013148
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
RAF activation R-HSA-5673000
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Rho GTPases R-HSA-194315
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling downstream of RAS mutants R-HSA-9649948
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF activation R-HSA-5673000
Signal Transduction R-HSA-162582
RAF/MAP kinase cascade R-HSA-5673001
RHO GTPase cycle R-HSA-9012999
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
CDC42 GTPase cycle R-HSA-9013148
Signaling by RAS mutants R-HSA-6802949
RHOG GTPase cycle R-HSA-9013408
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOV GTPase cycle R-HSA-9013424
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Oncogenic MAPK signaling R-HSA-6802957
Oncogenic MAPK signaling R-HSA-6802957
Signaling downstream of RAS mutants R-HSA-9649948
Signal Transduction R-HSA-162582
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RHOG GTPase cycle R-HSA-9013408
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHO GTPase cycle R-HSA-9012999
RAF/MAP kinase cascade R-HSA-5673001
CDC42 GTPase cycle R-HSA-9013148
RHOV GTPase cycle R-HSA-9013424
Signaling by RAS mutants R-HSA-6802949
RHO GTPase cycle R-HSA-9012999
Signal Transduction R-HSA-162582
RHOV GTPase cycle R-HSA-9013424
Signaling downstream of RAS mutants R-HSA-9649948
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK family signaling cascades R-HSA-5683057
Signaling by RAS mutants R-HSA-6802949
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Oncogenic MAPK signaling R-HSA-6802957
CDC42 GTPase cycle R-HSA-9013148
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Disease R-HSA-1643685
Signaling by Rho GTPases R-HSA-194315
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RHOG GTPase cycle R-HSA-9013408
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
CDC42 GTPase cycle R-HSA-9013148
Signaling by RAS mutants R-HSA-6802949
Signaling downstream of RAS mutants R-HSA-9649948
MAPK1/MAPK3 signaling R-HSA-5684996
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RHOG GTPase cycle R-HSA-9013408
Signaling by Rho GTPases R-HSA-194315
RHOV GTPase cycle R-HSA-9013424
Disease R-HSA-1643685
RHO GTPase cycle R-HSA-9012999
MAPK family signaling cascades R-HSA-5683057
RAF/MAP kinase cascade R-HSA-5673001
RAF activation R-HSA-5673000
Signal Transduction R-HSA-162582
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
CDC42 GTPase cycle R-HSA-9013148
RHOG GTPase cycle R-HSA-9013408
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK family signaling cascades R-HSA-5683057
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
RAF/MAP kinase cascade R-HSA-5673001
RHOV GTPase cycle R-HSA-9013424
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Signaling by RAS mutants R-HSA-6802949
Signaling downstream of RAS mutants R-HSA-9649948
RHO GTPase cycle R-HSA-9012999
Signaling by Rho GTPases R-HSA-194315
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Signaling downstream of RAS mutants R-HSA-9649948
RAF activation R-HSA-5673000
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAS mutants R-HSA-6802949
RHOV GTPase cycle R-HSA-9013424
RHO GTPase cycle R-HSA-9012999
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
CDC42 GTPase cycle R-HSA-9013148
RHOG GTPase cycle R-HSA-9013408
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
CDC42 GTPase cycle R-HSA-9013148
Signal Transduction R-HSA-162582
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
RHOV GTPase cycle R-HSA-9013424
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Rho GTPases R-HSA-194315
RAF/MAP kinase cascade R-HSA-5673001
RHO GTPase cycle R-HSA-9012999
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOG GTPase cycle R-HSA-9013408
Signaling by RAS mutants R-HSA-6802949
MAPK family signaling cascades R-HSA-5683057
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542

Expression Atlas ENSG00000173327
NCBI gene (formerly Entrezgene) 4296
GeneCards 6850
HGNC Symbol HGNC:6850
MIM gene 600050
UniProtKB Gene Name Q16584
WikiGene 4296
Gene: CHEK2
Ensembl ID : ENSG00000183765
Description: checkpoint kinase 2
Gene Synonyms: BA444G7,CDS1,CHK2,HUCDS1,PP1425,RAD53
2 APIs:
206 Possible Orthologues:

Regulation of TP53 Activity R-HSA-5633007
DNA Repair R-HSA-73894
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Regulation of TP53 Degradation R-HSA-6804757
DNA Double Strand Break Response R-HSA-5693606
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
DNA Double-Strand Break Repair R-HSA-5693532
RNA Polymerase II Transcription R-HSA-73857
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of TP53 Expression and Degradation R-HSA-6806003
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity through Methylation R-HSA-6804760
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cell Cycle Checkpoints R-HSA-69620
p53-Dependent G1 DNA Damage Response R-HSA-69563
Gene expression (Transcription) R-HSA-74160
Transcriptional Regulation by TP53 R-HSA-3700989
Stabilization of p53 R-HSA-69541
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent DNA Damage Response R-HSA-69610
Cell Cycle Checkpoints R-HSA-69620
G2/M DNA damage checkpoint R-HSA-69473
Cell Cycle R-HSA-1640170
p53-Independent DNA Damage Response R-HSA-69610
G2/M Checkpoints R-HSA-69481
Transcriptional Regulation by TP53 R-HSA-3700989
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
DNA Repair R-HSA-73894
Regulation of TP53 Degradation R-HSA-6804757
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Generic Transcription Pathway R-HSA-212436
Stabilization of p53 R-HSA-69541
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
p53-Dependent G1 DNA Damage Response R-HSA-69563
G1/S DNA Damage Checkpoints R-HSA-69615
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Activity R-HSA-5633007
DNA Double Strand Break Response R-HSA-5693606
Regulation of TP53 Expression and Degradation R-HSA-6806003
DNA Double-Strand Break Repair R-HSA-5693532
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
Regulation of TP53 Activity through Methylation R-HSA-6804760
Regulation of TP53 Degradation R-HSA-6804757
p53-Independent DNA Damage Response R-HSA-69610
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Cell Cycle Checkpoints R-HSA-69620
G1/S DNA Damage Checkpoints R-HSA-69615
DNA Repair R-HSA-73894
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity through Methylation R-HSA-6804760
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Regulation of TP53 Activity R-HSA-5633007
DNA Double Strand Break Response R-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Regulation of TP53 Expression and Degradation R-HSA-6806003
RNA Polymerase II Transcription R-HSA-73857
Stabilization of p53 R-HSA-69541
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Double-Strand Break Repair R-HSA-5693532
p53-Dependent G1 DNA Damage Response R-HSA-69563
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Gene expression (Transcription) R-HSA-74160
Cell Cycle R-HSA-1640170
G2/M DNA damage checkpoint R-HSA-69473
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Generic Transcription Pathway R-HSA-212436
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
G2/M DNA damage checkpoint R-HSA-69473
G2/M Checkpoints R-HSA-69481
Cell Cycle Checkpoints R-HSA-69620
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
p53-Independent DNA Damage Response R-HSA-69610
Regulation of TP53 Activity through Methylation R-HSA-6804760
p53-Dependent G1 DNA Damage Response R-HSA-69563
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity R-HSA-5633007
Regulation of TP53 Degradation R-HSA-6804757
Cell Cycle R-HSA-1640170
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of TP53 Expression and Degradation R-HSA-6806003
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
DNA Double Strand Break Response R-HSA-5693606
Stabilization of p53 R-HSA-69541
RNA Polymerase II Transcription R-HSA-73857
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
DNA Double-Strand Break Repair R-HSA-5693532
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Repair R-HSA-73894
DNA Repair R-HSA-73894
G2/M Checkpoints R-HSA-69481
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cell Cycle Checkpoints R-HSA-69620
DNA Double Strand Break Response R-HSA-5693606
Cell Cycle R-HSA-1640170
G2/M DNA damage checkpoint R-HSA-69473
p53-Dependent G1 DNA Damage Response R-HSA-69563
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Regulation of TP53 Activity R-HSA-5633007
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by TP53 R-HSA-3700989
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Degradation R-HSA-6804757
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity through Methylation R-HSA-6804760
RNA Polymerase II Transcription R-HSA-73857
p53-Independent DNA Damage Response R-HSA-69610
Stabilization of p53 R-HSA-69541
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Transcriptional Regulation by TP53 R-HSA-3700989
G1/S DNA Damage Checkpoints R-HSA-69615
Cell Cycle Checkpoints R-HSA-69620
Regulation of TP53 Degradation R-HSA-6804757
Regulation of TP53 Expression and Degradation R-HSA-6806003
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
p53-Dependent G1 DNA Damage Response R-HSA-69563
Regulation of TP53 Activity through Methylation R-HSA-6804760
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of TP53 Activity R-HSA-5633007
DNA Repair R-HSA-73894
Cell Cycle R-HSA-1640170
DNA Double-Strand Break Repair R-HSA-5693532
Stabilization of p53 R-HSA-69541
DNA Double Strand Break Response R-HSA-5693606
p53-Independent DNA Damage Response R-HSA-69610
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Generic Transcription Pathway R-HSA-212436
G2/M DNA damage checkpoint R-HSA-69473
RNA Polymerase II Transcription R-HSA-73857
G2/M Checkpoints R-HSA-69481
DNA Double Strand Break Response R-HSA-5693606
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle R-HSA-1640170
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Activity through Methylation R-HSA-6804760
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Dependent G1 DNA Damage Response R-HSA-69563
G2/M DNA damage checkpoint R-HSA-69473
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Expression and Degradation R-HSA-6806003
Regulation of TP53 Degradation R-HSA-6804757
RNA Polymerase II Transcription R-HSA-73857
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Regulation of TP53 Activity R-HSA-5633007
G1/S DNA Damage Checkpoints R-HSA-69615
DNA Repair R-HSA-73894
Generic Transcription Pathway R-HSA-212436
Stabilization of p53 R-HSA-69541
Cell Cycle Checkpoints R-HSA-69620
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G2/M Checkpoints R-HSA-69481
DNA Double-Strand Break Repair R-HSA-5693532
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
p53-Independent DNA Damage Response R-HSA-69610
Stabilization of p53 R-HSA-69541
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cell Cycle R-HSA-1640170
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Checkpoints R-HSA-69481
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Regulation of TP53 Activity through Methylation R-HSA-6804760
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Dependent G1 DNA Damage Response R-HSA-69563
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Degradation R-HSA-6804757
DNA Repair R-HSA-73894
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
G2/M DNA damage checkpoint R-HSA-69473
Regulation of TP53 Activity R-HSA-5633007
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Independent DNA Damage Response R-HSA-69610
DNA Double Strand Break Response R-HSA-5693606
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle Checkpoints R-HSA-69620
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
p53-Dependent G1 DNA Damage Response R-HSA-69563
DNA Double Strand Break Response R-HSA-5693606
Regulation of TP53 Activity through Methylation R-HSA-6804760
Transcriptional Regulation by TP53 R-HSA-3700989
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Cell Cycle Checkpoints R-HSA-69620
Cell Cycle R-HSA-1640170
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
p53-Independent DNA Damage Response R-HSA-69610
G2/M Checkpoints R-HSA-69481
Generic Transcription Pathway R-HSA-212436
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity R-HSA-5633007
RNA Polymerase II Transcription R-HSA-73857
DNA Repair R-HSA-73894
Regulation of TP53 Expression and Degradation R-HSA-6806003
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
DNA Double-Strand Break Repair R-HSA-5693532
Stabilization of p53 R-HSA-69541
G1/S DNA Damage Checkpoints R-HSA-69615
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Regulation of TP53 Degradation R-HSA-6804757
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
G2/M DNA damage checkpoint R-HSA-69473
Stabilization of p53 R-HSA-69541
Regulation of TP53 Activity R-HSA-5633007
Regulation of TP53 Degradation R-HSA-6804757
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
DNA Double Strand Break Response R-HSA-5693606
Cell Cycle R-HSA-1640170
G2/M Checkpoints R-HSA-69481
DNA Repair R-HSA-73894
p53-Independent DNA Damage Response R-HSA-69610
DNA Double-Strand Break Repair R-HSA-5693532
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Expression and Degradation R-HSA-6806003
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Regulation of TP53 Activity through Methylation R-HSA-6804760
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Dependent G1 DNA Damage Response R-HSA-69563
Cell Cycle Checkpoints R-HSA-69620
Transcriptional Regulation by TP53 R-HSA-3700989
DNA Repair R-HSA-73894
Gene expression (Transcription) R-HSA-74160
p53-Independent DNA Damage Response R-HSA-69610
DNA Double Strand Break Response R-HSA-5693606
Generic Transcription Pathway R-HSA-212436
Stabilization of p53 R-HSA-69541
Regulation of TP53 Degradation R-HSA-6804757
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of TP53 Expression and Degradation R-HSA-6806003
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Cell Cycle R-HSA-1640170
DNA Double-Strand Break Repair R-HSA-5693532
G2/M DNA damage checkpoint R-HSA-69473
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity through Methylation R-HSA-6804760
p53-Dependent G1 DNA Damage Response R-HSA-69563
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693565
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
RNA Polymerase II Transcription R-HSA-73857
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cell Cycle Checkpoints R-HSA-69620
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity R-HSA-5633007

Expression Atlas ENSG00000183765
LRG display in Ensembl gene LRG_302
NCBI gene (formerly Entrezgene) 11200
GeneCards 16627
HGNC Symbol HGNC:16627
MIM gene 604373
MIM morbid 609265
UniProtKB Gene Name O96017
WikiGene 11200
Gene: PIK3CA
Ensembl ID : ENSG00000121879
Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Gene Synonyms: PI3K
36 APIs:
272 Possible Orthologues:

Hemostasis R-HSA-109582
PI3K Cascade R-HSA-109704
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by Insulin receptor R-HSA-74752
IRS-mediated signalling R-HSA-112399
Activated NTRK3 signals through PI3K R-HSA-9603381
RAC1 GTPase cycle R-HSA-9013149
Signaling by NTRK2 (TRKB) R-HSA-9006115
VEGFA-VEGFR2 Pathway R-HSA-4420097
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by ERBB2 in Cancer R-HSA-1227990
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by ALK fusions and activated point mutants R-HSA-9725370
PI-3K cascade:FGFR3 R-HSA-5654710
Hemostasis R-HSA-109582
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR2 R-HSA-5654738
Interleukin receptor SHC signaling R-HSA-912526
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by FGFR1 in disease R-HSA-5655302
IGF1R signaling cascade R-HSA-2428924
Interleukin-2 family signaling R-HSA-451927
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by NTRK1 (TRKA) R-HSA-187037
Role of phospholipids in phagocytosis R-HSA-2029485
RET signaling R-HSA-8853659
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
PI-3K cascade:FGFR2 R-HSA-5654695
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
RAF/MAP kinase cascade R-HSA-5673001
Phospholipid metabolism R-HSA-1483257
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by Interleukins R-HSA-449147
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
PI-3K cascade:FGFR1 R-HSA-5654689
Downstream TCR signaling R-HSA-202424
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by ALK R-HSA-201556
CD28 co-stimulation R-HSA-389356
Disease R-HSA-1643685
Nephrin family interactions R-HSA-373753
PI3K events in ERBB2 signaling R-HSA-1963642
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
ESR-mediated signaling R-HSA-8939211
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by SCF-KIT R-HSA-1433557
Signaling by ALK in cancer R-HSA-9700206
PI3K Cascade R-HSA-109704
MET activates PI3K/AKT signaling R-HSA-8851907
DAP12 interactions R-HSA-2172127
Regulation of signaling by CBL R-HSA-912631
PI-3K cascade:FGFR4 R-HSA-5654720
Signaling by Rho GTPases R-HSA-194315
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
DAP12 signaling R-HSA-2424491
Signaling by MET R-HSA-6806834
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by FGFR R-HSA-190236
RAC2 GTPase cycle R-HSA-9013404
GPVI-mediated activation cascade R-HSA-114604
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by PDGFR in disease R-HSA-9671555
Signaling by EGFR in Cancer R-HSA-1643713
GAB1 signalosome R-HSA-180292
Signaling by NTRKs R-HSA-166520
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
Axon guidance R-HSA-422475
Signaling by FGFR1 R-HSA-5654736
Immune System R-HSA-168256
Signaling by ERBB4 R-HSA-1236394
Downstream signaling of activated FGFR1 R-HSA-5654687
FLT3 signaling in disease R-HSA-9682385
TCR signaling R-HSA-202403
Signaling by FGFR3 R-HSA-5654741
Signaling by Erythropoietin R-HSA-9006335
FLT3 Signaling R-HSA-9607240
Cell-Cell communication R-HSA-1500931
PI3K events in ERBB4 signaling R-HSA-1250342
Innate Immune System R-HSA-168249
Signal Transduction R-HSA-162582
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Activated NTRK2 signals through PI3K R-HSA-9028335
G alpha (q) signalling events R-HSA-416476
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Extra-nuclear estrogen signaling R-HSA-9009391
Costimulation by the CD28 family R-HSA-388841
Signaling by FGFR2 in disease R-HSA-5655253
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FLT3 fusion proteins R-HSA-9703465
CD28 dependent PI3K/Akt signaling R-HSA-389357
MAPK1/MAPK3 signaling R-HSA-5684996
Nervous system development R-HSA-9675108
GPCR downstream signalling R-HSA-388396
Intracellular signaling by second messengers R-HSA-9006925
Signaling by GPCR R-HSA-372790
Tie2 Signaling R-HSA-210993
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by KIT in disease R-HSA-9669938
Synthesis of PIPs at the plasma membrane R-HSA-1660499
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by PDGF R-HSA-186797
Downstream signal transduction R-HSA-186763
Adaptive Immune System R-HSA-1280218
Metabolism R-HSA-1430728
Signaling by ERBB2 R-HSA-1227986
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by FGFR3 in disease R-HSA-5655332
Signaling by EGFR R-HSA-177929
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Insulin receptor signalling cascade R-HSA-74751
PIP3 activates AKT signaling R-HSA-1257604
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signaling by FGFR4 R-HSA-5654743
Developmental Biology R-HSA-1266738
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
PI3K/AKT activation R-HSA-198203
PI Metabolism R-HSA-1483255
Metabolism of lipids R-HSA-556833
Signaling by VEGF R-HSA-194138
PI-3K cascade:FGFR1 R-HSA-5654689
Adaptive Immune System R-HSA-1280218
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by GPCR R-HSA-372790
Signaling by KIT in disease R-HSA-9669938
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by ALK in cancer R-HSA-9700206
Signaling by Insulin receptor R-HSA-74752
Signaling by PDGFR in disease R-HSA-9671555
CD28 dependent PI3K/Akt signaling R-HSA-389357
PI3K/AKT activation R-HSA-198203
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by NTRK2 (TRKB) R-HSA-9006115
PI3K events in ERBB2 signaling R-HSA-1963642
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Signaling by ERBB2 R-HSA-1227986
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by ERBB2 in Cancer R-HSA-1227990
Immune System R-HSA-168256
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Downstream signaling of activated FGFR2 R-HSA-5654696
DAP12 interactions R-HSA-2172127
Signaling by Rho GTPases R-HSA-194315
FLT3 Signaling R-HSA-9607240
Metabolism of lipids R-HSA-556833
Signaling by FGFR4 R-HSA-5654743
GPVI-mediated activation cascade R-HSA-114604
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
DAP12 signaling R-HSA-2424491
FLT3 signaling in disease R-HSA-9682385
Signaling by ALK fusions and activated point mutants R-HSA-9725370
PI3K events in ERBB4 signaling R-HSA-1250342
PI Metabolism R-HSA-1483255
Activated NTRK3 signals through PI3K R-HSA-9603381
IGF1R signaling cascade R-HSA-2428924
ESR-mediated signaling R-HSA-8939211
Downstream signaling of activated FGFR3 R-HSA-5654708
RAF/MAP kinase cascade R-HSA-5673001
Axon guidance R-HSA-422475
Signaling by PDGF R-HSA-186797
Signaling by FGFR4 in disease R-HSA-5655291
GAB1 signalosome R-HSA-180292
Disease R-HSA-1643685
Regulation of signaling by CBL R-HSA-912631
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Costimulation by the CD28 family R-HSA-388841
Signaling by SCF-KIT R-HSA-1433557
Signaling by FGFR R-HSA-190236
Developmental Biology R-HSA-1266738
Signaling by NTRKs R-HSA-166520
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Intracellular signaling by second messengers R-HSA-9006925
Tie2 Signaling R-HSA-210993
Activated NTRK2 signals through PI3K R-HSA-9028335
RET signaling R-HSA-8853659
Downstream TCR signaling R-HSA-202424
GPCR downstream signalling R-HSA-388396
MAPK1/MAPK3 signaling R-HSA-5684996
Role of phospholipids in phagocytosis R-HSA-2029485
CD28 co-stimulation R-HSA-389356
VEGFA-VEGFR2 Pathway R-HSA-4420097
TCR signaling R-HSA-202403
Interleukin receptor SHC signaling R-HSA-912526
Signaling by EGFRvIII in Cancer R-HSA-5637812
RAC1 GTPase cycle R-HSA-9013149
PI3K/AKT Signaling in Cancer R-HSA-2219528
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Insulin receptor signalling cascade R-HSA-74751
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by FGFR3 in disease R-HSA-5655332
RHO GTPase cycle R-HSA-9012999
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by Nuclear Receptors R-HSA-9006931
PIP3 activates AKT signaling R-HSA-1257604
Signaling by NTRK3 (TRKC) R-HSA-9034015
Innate Immune System R-HSA-168249
Phospholipid metabolism R-HSA-1483257
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by FGFR in disease R-HSA-1226099
Signaling by MET R-HSA-6806834
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by FGFR1 R-HSA-5654736
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Cell-Cell communication R-HSA-1500931
IRS-related events triggered by IGF1R R-HSA-2428928
Nervous system development R-HSA-9675108
Interleukin-2 family signaling R-HSA-451927
Signaling by Interleukins R-HSA-449147
Negative regulation of the PI3K/AKT network R-HSA-199418
Nephrin family interactions R-HSA-373753
Cytokine Signaling in Immune system R-HSA-1280215
Platelet activation, signaling and aggregation R-HSA-76002
IRS-mediated signalling R-HSA-112399
Signal Transduction R-HSA-162582
Signaling by ERBB4 R-HSA-1236394
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Metabolism R-HSA-1430728
Signaling by EGFR R-HSA-177929
PI3K Cascade R-HSA-109704
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by ALK R-HSA-201556
FGFR1 mutant receptor activation R-HSA-1839124
MAPK family signaling cascades R-HSA-5683057
Extra-nuclear estrogen signaling R-HSA-9009391
Downstream signal transduction R-HSA-186763
Constitutive Signaling by EGFRvIII R-HSA-5637810
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by FLT3 fusion proteins R-HSA-9703465
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR2 R-HSA-5654738
Signaling by ERBB2 KD Mutants R-HSA-9664565
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
PI-3K cascade:FGFR3 R-HSA-5654710
PI-3K cascade:FGFR4 R-HSA-5654720
Signaling by FGFR3 R-HSA-5654741
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signaling by FGFR2 in disease R-HSA-5655253
Signaling by VEGF R-HSA-194138
RAC2 GTPase cycle R-HSA-9013404
G alpha (q) signalling events R-HSA-416476
Signaling by Erythropoietin R-HSA-9006335
MET activates PI3K/AKT signaling R-HSA-8851907
Signaling by FGFR in disease R-HSA-1226099
Signaling by ALK in cancer R-HSA-9700206
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by FGFR4 in disease R-HSA-5655291
Cell surface interactions at the vascular wall R-HSA-202733
DAP12 signaling R-HSA-2424491
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by ALK R-HSA-201556
Metabolism of lipids R-HSA-556833
MAPK family signaling cascades R-HSA-5683057
PI-3K cascade:FGFR2 R-HSA-5654695
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by ERBB4 R-HSA-1236394
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by FGFR R-HSA-190236
Cytokine Signaling in Immune system R-HSA-1280215
TCR signaling R-HSA-202403
CD28 dependent PI3K/Akt signaling R-HSA-389357
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by GPCR R-HSA-372790
Downstream TCR signaling R-HSA-202424
Signaling by ERBB2 ECD mutants R-HSA-9665348
FLT3 Signaling R-HSA-9607240
Signaling by EGFR R-HSA-177929
PI3K/AKT Signaling in Cancer R-HSA-2219528
Immune System R-HSA-168256
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by PDGF R-HSA-186797
Adaptive Immune System R-HSA-1280218
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by FGFR2 R-HSA-5654738
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
G alpha (q) signalling events R-HSA-416476
Signaling by Rho GTPases R-HSA-194315
PI Metabolism R-HSA-1483255
Phospholipid metabolism R-HSA-1483257
FLT3 signaling in disease R-HSA-9682385
Interleukin receptor SHC signaling R-HSA-912526
RET signaling R-HSA-8853659
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by FGFR3 in disease R-HSA-5655332
Nervous system development R-HSA-9675108
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by EGFRvIII in Cancer R-HSA-5637812
Constitutive Signaling by EGFRvIII R-HSA-5637810
IGF1R signaling cascade R-HSA-2428924
GAB1 signalosome R-HSA-180292
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
RHO GTPase cycle R-HSA-9012999
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
PI-3K cascade:FGFR4 R-HSA-5654720
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by MET R-HSA-6806834
Downstream signal transduction R-HSA-186763
Signaling by NTRK3 (TRKC) R-HSA-9034015
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by VEGF R-HSA-194138
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR1 R-HSA-5654736
Cell-Cell communication R-HSA-1500931
Signaling by FGFR4 R-HSA-5654743
Signal Transduction R-HSA-162582
Signaling by ERBB2 R-HSA-1227986
Role of phospholipids in phagocytosis R-HSA-2029485
IRS-mediated signalling R-HSA-112399
Signaling by Interleukins R-HSA-449147
Signaling by Erythropoietin R-HSA-9006335
Activated NTRK2 signals through PI3K R-HSA-9028335
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PIP3 activates AKT signaling R-HSA-1257604
Innate Immune System R-HSA-168249
Signaling by KIT in disease R-HSA-9669938
MET activates PI3K/AKT signaling R-HSA-8851907
RAF/MAP kinase cascade R-HSA-5673001
GPCR downstream signalling R-HSA-388396
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Axon guidance R-HSA-422475
Hemostasis R-HSA-109582
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by NTRKs R-HSA-166520
Signaling by PDGFR in disease R-HSA-9671555
Intracellular signaling by second messengers R-HSA-9006925
Regulation of signaling by CBL R-HSA-912631
ESR-mediated signaling R-HSA-8939211
Developmental Biology R-HSA-1266738
Signaling by SCF-KIT R-HSA-1433557
GPVI-mediated activation cascade R-HSA-114604
DAP12 interactions R-HSA-2172127
CD28 co-stimulation R-HSA-389356
Costimulation by the CD28 family R-HSA-388841
Platelet activation, signaling and aggregation R-HSA-76002
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
RAC2 GTPase cycle R-HSA-9013404
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
PI3K/AKT activation R-HSA-198203
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Insulin receptor R-HSA-74752
Nephrin family interactions R-HSA-373753
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Interleukin-2 family signaling R-HSA-451927
Downstream signaling of activated FGFR2 R-HSA-5654696
Activated NTRK3 signals through PI3K R-HSA-9603381
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
PI3K Cascade R-HSA-109704
PI3K events in ERBB4 signaling R-HSA-1250342
PI-3K cascade:FGFR3 R-HSA-5654710
Synthesis of PIPs at the plasma membrane R-HSA-1660499
RAC1 GTPase cycle R-HSA-9013149
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by FGFR2 in disease R-HSA-5655253
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by EGFR in Cancer R-HSA-1643713
Insulin receptor signalling cascade R-HSA-74751
Tie2 Signaling R-HSA-210993
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR3 R-HSA-5654741
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Metabolism R-HSA-1430728
PI3K events in ERBB2 signaling R-HSA-1963642
Disease R-HSA-1643685
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by ERBB2 KD Mutants R-HSA-9664565
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR3 R-HSA-5654741
Downstream signal transduction R-HSA-186763
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by FGFR4 in disease R-HSA-5655291
Downstream signaling of activated FGFR1 R-HSA-5654687
FLT3 Signaling R-HSA-9607240
Downstream TCR signaling R-HSA-202424
CD28 dependent PI3K/Akt signaling R-HSA-389357
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Signaling by KIT in disease R-HSA-9669938
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by FGFR1 in disease R-HSA-5655302
Developmental Biology R-HSA-1266738
Signaling by PDGF R-HSA-186797
Cytokine Signaling in Immune system R-HSA-1280215
Immune System R-HSA-168256
Signaling by FGFR3 in disease R-HSA-5655332
Signal Transduction R-HSA-162582
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by SCF-KIT R-HSA-1433557
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
MAPK family signaling cascades R-HSA-5683057
Disease R-HSA-1643685
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by FGFR4 R-HSA-5654743
FLT3 signaling in disease R-HSA-9682385
FGFR1 mutant receptor activation R-HSA-1839124
IRS-mediated signalling R-HSA-112399
Axon guidance R-HSA-422475
Downstream signaling of activated FGFR4 R-HSA-5654716
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Tie2 Signaling R-HSA-210993
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Costimulation by the CD28 family R-HSA-388841
Signaling by PDGFR in disease R-HSA-9671555
Role of phospholipids in phagocytosis R-HSA-2029485
Negative regulation of the PI3K/AKT network R-HSA-199418
G alpha (q) signalling events R-HSA-416476
Signaling by FGFR2 in disease R-HSA-5655253
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ALK in cancer R-HSA-9700206
Interleukin-2 family signaling R-HSA-451927
Signaling by EGFR R-HSA-177929
DAP12 interactions R-HSA-2172127
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
RAC1 GTPase cycle R-HSA-9013149
PI3K Cascade R-HSA-109704
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by FGFR R-HSA-190236
Nephrin family interactions R-HSA-373753
Interleukin receptor SHC signaling R-HSA-912526
RHO GTPase cycle R-HSA-9012999
Signaling by EGFRvIII in Cancer R-HSA-5637812
TCR signaling R-HSA-202403
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by NTRK3 (TRKC) R-HSA-9034015
RAC2 GTPase cycle R-HSA-9013404
Nervous system development R-HSA-9675108
GPVI-mediated activation cascade R-HSA-114604
Innate Immune System R-HSA-168249
Adaptive Immune System R-HSA-1280218
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
GPCR downstream signalling R-HSA-388396
Signaling by ALK fusions and activated point mutants R-HSA-9725370
PI-3K cascade:FGFR4 R-HSA-5654720
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
DAP12 signaling R-HSA-2424491
Signaling by NTRKs R-HSA-166520
Insulin receptor signalling cascade R-HSA-74751
Signaling by GPCR R-HSA-372790
Signaling by ERBB4 R-HSA-1236394
Signaling by ALK R-HSA-201556
Signaling by Interleukins R-HSA-449147
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
CD28 co-stimulation R-HSA-389356
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Signaling by NTRK2 (TRKB) R-HSA-9006115
GAB1 signalosome R-HSA-180292
Signaling by NTRK1 (TRKA) R-HSA-187037
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR1 R-HSA-5654736
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IRS-related events triggered by IGF1R R-HSA-2428928
RET signaling R-HSA-8853659
Downstream signaling of activated FGFR2 R-HSA-5654696
Constitutive Signaling by EGFRvIII R-HSA-5637810
Downstream signaling of activated FGFR3 R-HSA-5654708
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by Insulin receptor R-HSA-74752
Signaling by FGFR2 R-HSA-5654738
Signaling by EGFR in Cancer R-HSA-1643713
PI-3K cascade:FGFR1 R-HSA-5654689
Activated NTRK3 signals through PI3K R-HSA-9603381
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by ERBB2 R-HSA-1227986
Signaling by VEGF R-HSA-194138
Hemostasis R-HSA-109582
RAF/MAP kinase cascade R-HSA-5673001
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by Erythropoietin R-HSA-9006335
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by MET R-HSA-6806834
PIP3 activates AKT signaling R-HSA-1257604
Cell-Cell communication R-HSA-1500931
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signaling by Rho GTPases R-HSA-194315
IGF1R signaling cascade R-HSA-2428924
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PI Metabolism R-HSA-1483255
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by ERBB2 ECD mutants R-HSA-9665348
Phospholipid metabolism R-HSA-1483257
PI3K/AKT activation R-HSA-198203
ESR-mediated signaling R-HSA-8939211
Signaling by Nuclear Receptors R-HSA-9006931
PI3K events in ERBB2 signaling R-HSA-1963642
Regulation of signaling by CBL R-HSA-912631
MET activates PI3K/AKT signaling R-HSA-8851907
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by FGFR2 R-HSA-5654738
Signaling by NTRK2 (TRKB) R-HSA-9006115
RAC1 GTPase cycle R-HSA-9013149
DAP12 interactions R-HSA-2172127
Signaling by Nuclear Receptors R-HSA-9006931
VEGFA-VEGFR2 Pathway R-HSA-4420097
FGFR1 mutant receptor activation R-HSA-1839124
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Role of phospholipids in phagocytosis R-HSA-2029485
Hemostasis R-HSA-109582
Disease R-HSA-1643685
Innate Immune System R-HSA-168249
RET signaling R-HSA-8853659
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
MET activates PI3K/AKT signaling R-HSA-8851907
FLT3 Signaling R-HSA-9607240
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by FGFR1 in disease R-HSA-5655302
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by ERBB2 ECD mutants R-HSA-9665348
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by Rho GTPases R-HSA-194315
Signaling by FGFR1 R-HSA-5654736
MAPK family signaling cascades R-HSA-5683057
Signaling by ERBB2 in Cancer R-HSA-1227990
Signal Transduction R-HSA-162582
Signaling by Insulin receptor R-HSA-74752
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Interleukin-2 family signaling R-HSA-451927
PI-3K cascade:FGFR1 R-HSA-5654689
GPCR downstream signalling R-HSA-388396
CD28 dependent PI3K/Akt signaling R-HSA-389357
Insulin receptor signalling cascade R-HSA-74751
Platelet activation, signaling and aggregation R-HSA-76002
IGF1R signaling cascade R-HSA-2428924
MAPK1/MAPK3 signaling R-HSA-5684996
PI-3K cascade:FGFR3 R-HSA-5654710
Signaling by ERBB2 R-HSA-1227986
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by FGFR3 R-HSA-5654741
Regulation of signaling by CBL R-HSA-912631
Immune System R-HSA-168256
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by ALK in cancer R-HSA-9700206
Signaling by ALK R-HSA-201556
Cell-Cell communication R-HSA-1500931
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K events in ERBB4 signaling R-HSA-1250342
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by PDGFR in disease R-HSA-9671555
Signaling by PDGF R-HSA-186797
Signaling by KIT in disease R-HSA-9669938
Signaling by ERBB2 KD Mutants R-HSA-9664565
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by GPCR R-HSA-372790
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
PI3K/AKT activation R-HSA-198203
Developmental Biology R-HSA-1266738
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
RAC2 GTPase cycle R-HSA-9013404
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Downstream signal transduction R-HSA-186763
Signaling by Interleukins R-HSA-449147
IRS-related events triggered by IGF1R R-HSA-2428928
CD28 co-stimulation R-HSA-389356
Signaling by FGFR2 in disease R-HSA-5655253
Metabolism of lipids R-HSA-556833
RAF/MAP kinase cascade R-HSA-5673001
Metabolism R-HSA-1430728
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Adaptive Immune System R-HSA-1280218
Signaling by NTRK1 (TRKA) R-HSA-187037
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Axon guidance R-HSA-422475
Signaling by EGFR R-HSA-177929
GPVI-mediated activation cascade R-HSA-114604
FLT3 signaling in disease R-HSA-9682385
Signaling by FGFR4 R-HSA-5654743
Nephrin family interactions R-HSA-373753
Signaling by FGFR3 in disease R-HSA-5655332
Nervous system development R-HSA-9675108
G alpha (q) signalling events R-HSA-416476
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Costimulation by the CD28 family R-HSA-388841
Activated NTRK3 signals through PI3K R-HSA-9603381
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
TCR signaling R-HSA-202403
Downstream signaling of activated FGFR4 R-HSA-5654716
PI Metabolism R-HSA-1483255
Signaling by FGFR R-HSA-190236
PIP3 activates AKT signaling R-HSA-1257604
Signaling by SCF-KIT R-HSA-1433557
GAB1 signalosome R-HSA-180292
IRS-mediated signalling R-HSA-112399
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by VEGF R-HSA-194138
Tie2 Signaling R-HSA-210993
Signaling by MET R-HSA-6806834
Signaling by ERBB4 R-HSA-1236394
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Extra-nuclear estrogen signaling R-HSA-9009391
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Intracellular signaling by second messengers R-HSA-9006925
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by EGFRvIII in Cancer R-HSA-5637812
PI3K Cascade R-HSA-109704
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Phospholipid metabolism R-HSA-1483257
Downstream TCR signaling R-HSA-202424
PI-3K cascade:FGFR4 R-HSA-5654720
Signaling by NTRKs R-HSA-166520
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Interleukin receptor SHC signaling R-HSA-912526
DAP12 signaling R-HSA-2424491
Signaling by Erythropoietin R-HSA-9006335
RHO GTPase cycle R-HSA-9012999
ESR-mediated signaling R-HSA-8939211
Signaling by FGFR in disease R-HSA-1226099
Cell surface interactions at the vascular wall R-HSA-202733
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by EGFR R-HSA-177929
Signaling by PDGF R-HSA-186797
Metabolism R-HSA-1430728
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by FGFR1 in disease R-HSA-5655302
PIP3 activates AKT signaling R-HSA-1257604
Activated NTRK3 signals through PI3K R-HSA-9603381
Role of phospholipids in phagocytosis R-HSA-2029485
Adaptive Immune System R-HSA-1280218
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
MAPK family signaling cascades R-HSA-5683057
Signaling by NTRK1 (TRKA) R-HSA-187037
Signal Transduction R-HSA-162582
PI-3K cascade:FGFR4 R-HSA-5654720
ESR-mediated signaling R-HSA-8939211
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by ALK R-HSA-201556
Cell surface interactions at the vascular wall R-HSA-202733
Costimulation by the CD28 family R-HSA-388841
Signaling by ALK in cancer R-HSA-9700206
Signaling by ERBB2 R-HSA-1227986
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by GPCR R-HSA-372790
DAP12 interactions R-HSA-2172127
Signaling by VEGF R-HSA-194138
Metabolism of lipids R-HSA-556833
Signaling by FGFR1 R-HSA-5654736
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by EGFR in Cancer R-HSA-1643713
PI-3K cascade:FGFR2 R-HSA-5654695
Signaling by Erythropoietin R-HSA-9006335
Signaling by FGFR in disease R-HSA-1226099
Signaling by FGFR3 R-HSA-5654741
Intracellular signaling by second messengers R-HSA-9006925
PI Metabolism R-HSA-1483255
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
RAF/MAP kinase cascade R-HSA-5673001
IRS-mediated signalling R-HSA-112399
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
FLT3 Signaling R-HSA-9607240
DAP12 signaling R-HSA-2424491
Interleukin receptor SHC signaling R-HSA-912526
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by NTRK3 (TRKC) R-HSA-9034015
FGFR1 mutant receptor activation R-HSA-1839124
Cell-Cell communication R-HSA-1500931
Hemostasis R-HSA-109582
RAC1 GTPase cycle R-HSA-9013149
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by FGFR4 R-HSA-5654743
Developmental Biology R-HSA-1266738
PI3K Cascade R-HSA-109704
PI3K events in ERBB4 signaling R-HSA-1250342
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Cytokine Signaling in Immune system R-HSA-1280215
Nephrin family interactions R-HSA-373753
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FLT3 signaling in disease R-HSA-9682385
IGF1R signaling cascade R-HSA-2428924
Signaling by ERBB4 R-HSA-1236394
Immune System R-HSA-168256
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by NTRK2 (TRKB) R-HSA-9006115
RET signaling R-HSA-8853659
IRS-related events triggered by IGF1R R-HSA-2428928
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by FLT3 fusion proteins R-HSA-9703465
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by NTRKs R-HSA-166520
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by SCF-KIT R-HSA-1433557
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by PDGFR in disease R-HSA-9671555
PI-3K cascade:FGFR3 R-HSA-5654710
G alpha (q) signalling events R-HSA-416476
RAC2 GTPase cycle R-HSA-9013404
Signaling by MET R-HSA-6806834
Signaling by Nuclear Receptors R-HSA-9006931
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Rho GTPases R-HSA-194315
GPCR downstream signalling R-HSA-388396
Signaling by FGFR2 R-HSA-5654738
Innate Immune System R-HSA-168249
Interleukin-2 family signaling R-HSA-451927
Downstream signaling of activated FGFR3 R-HSA-5654708
Downstream signaling of activated FGFR1 R-HSA-5654687
MET activates PI3K/AKT signaling R-HSA-8851907
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by Insulin receptor R-HSA-74752
RHO GTPase cycle R-HSA-9012999
Signaling by ERBB2 in Cancer R-HSA-1227990
CD28 co-stimulation R-HSA-389356
Activated NTRK2 signals through PI3K R-HSA-9028335
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by Interleukins R-HSA-449147
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR3 in disease R-HSA-5655332
Downstream signal transduction R-HSA-186763
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by FGFR2 in disease R-HSA-5655253
GPVI-mediated activation cascade R-HSA-114604
Constitutive Signaling by EGFRvIII R-HSA-5637810
Nervous system development R-HSA-9675108
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by FGFR R-HSA-190236
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by ERBB2 ECD mutants R-HSA-9665348
Tie2 Signaling R-HSA-210993
Signaling by EGFRvIII in Cancer R-HSA-5637812
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Signaling by FGFR4 in disease R-HSA-5655291
MAPK1/MAPK3 signaling R-HSA-5684996
Regulation of signaling by CBL R-HSA-912631
Axon guidance R-HSA-422475
Signaling by KIT in disease R-HSA-9669938
Insulin receptor signalling cascade R-HSA-74751
Phospholipid metabolism R-HSA-1483257
Signaling by ERBB2 KD Mutants R-HSA-9664565
PI3K/AKT activation R-HSA-198203
Downstream TCR signaling R-HSA-202424
GAB1 signalosome R-HSA-180292
TCR signaling R-HSA-202403
Innate Immune System R-HSA-168249
Signaling by ALK in cancer R-HSA-9700206
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by ERBB2 ECD mutants R-HSA-9665348
Role of phospholipids in phagocytosis R-HSA-2029485
Signaling by Insulin receptor R-HSA-74752
PI-3K cascade:FGFR1 R-HSA-5654689
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by Erythropoietin R-HSA-9006335
G alpha (q) signalling events R-HSA-416476
Signaling by EGFR in Cancer R-HSA-1643713
Downstream signaling of activated FGFR1 R-HSA-5654687
GAB1 signalosome R-HSA-180292
Cell surface interactions at the vascular wall R-HSA-202733
Downstream signaling of activated FGFR2 R-HSA-5654696
PI3K Cascade R-HSA-109704
MAPK1/MAPK3 signaling R-HSA-5684996
Downstream signal transduction R-HSA-186763
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Hemostasis R-HSA-109582
PI-3K cascade:FGFR4 R-HSA-5654720
RHO GTPase cycle R-HSA-9012999
IGF1R signaling cascade R-HSA-2428924
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by FGFR3 in disease R-HSA-5655332
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
DAP12 signaling R-HSA-2424491
RAC1 GTPase cycle R-HSA-9013149
Signaling by SCF-KIT R-HSA-1433557
DAP12 interactions R-HSA-2172127
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR in disease R-HSA-1226099
RAC2 GTPase cycle R-HSA-9013404
Nephrin family interactions R-HSA-373753
Downstream TCR signaling R-HSA-202424
Signaling by ALK R-HSA-201556
Signaling by Interleukins R-HSA-449147
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NTRK3 (TRKC) R-HSA-9034015
Costimulation by the CD28 family R-HSA-388841
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR2 in disease R-HSA-5655253
Interleukin-2 family signaling R-HSA-451927
Signaling by FGFR4 R-HSA-5654743
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
RET signaling R-HSA-8853659
PI3K events in ERBB2 signaling R-HSA-1963642
Interleukin receptor SHC signaling R-HSA-912526
IRS-related events triggered by IGF1R R-HSA-2428928
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Signaling by FGFR R-HSA-190236
Signaling by PDGF R-HSA-186797
Signaling by ERBB2 R-HSA-1227986
PIP3 activates AKT signaling R-HSA-1257604
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by ERBB2 KD Mutants R-HSA-9664565
Adaptive Immune System R-HSA-1280218
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
MET activates PI3K/AKT signaling R-HSA-8851907
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Insulin receptor signalling cascade R-HSA-74751
IRS-mediated signalling R-HSA-112399
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by PDGFR in disease R-HSA-9671555
Axon guidance R-HSA-422475
Activated NTRK2 signals through PI3K R-HSA-9028335
Phospholipid metabolism R-HSA-1483257
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by VEGF R-HSA-194138
Tie2 Signaling R-HSA-210993
Cell-Cell communication R-HSA-1500931
Metabolism of lipids R-HSA-556833
Developmental Biology R-HSA-1266738
Signaling by GPCR R-HSA-372790
PI3K/AKT Signaling in Cancer R-HSA-2219528
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by KIT in disease R-HSA-9669938
GPVI-mediated activation cascade R-HSA-114604
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
FLT3 Signaling R-HSA-9607240
RAF/MAP kinase cascade R-HSA-5673001
Intracellular signaling by second messengers R-HSA-9006925
Negative regulation of the PI3K/AKT network R-HSA-199418
PI-3K cascade:FGFR2 R-HSA-5654695
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
FLT3 signaling in disease R-HSA-9682385
Signal Transduction R-HSA-162582
Signaling by EGFR R-HSA-177929
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by Nuclear Receptors R-HSA-9006931
TCR signaling R-HSA-202403
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by ERBB4 R-HSA-1236394
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by MET R-HSA-6806834
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI-3K cascade:FGFR3 R-HSA-5654710
GPCR downstream signalling R-HSA-388396
Immune System R-HSA-168256
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
CD28 co-stimulation R-HSA-389356
Metabolism R-HSA-1430728
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by FGFR2 R-HSA-5654738
Extra-nuclear estrogen signaling R-HSA-9009391
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Regulation of signaling by CBL R-HSA-912631
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Rho GTPases R-HSA-194315
Signaling by FGFR1 R-HSA-5654736
ESR-mediated signaling R-HSA-8939211
Signaling by FGFR3 R-HSA-5654741
PI Metabolism R-HSA-1483255
Disease R-HSA-1643685
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by EGFRvIII in Cancer R-HSA-5637812
Activated NTRK3 signals through PI3K R-HSA-9603381
Nervous system development R-HSA-9675108
Signaling by NTRKs R-HSA-166520
PI3K/AKT activation R-HSA-198203
Cytokine Signaling in Immune system R-HSA-1280215
Downstream signaling of activated FGFR4 R-HSA-5654716
Role of phospholipids in phagocytosis R-HSA-2029485
Intracellular signaling by second messengers R-HSA-9006925
Signaling by GPCR R-HSA-372790
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
RHO GTPase cycle R-HSA-9012999
DAP12 interactions R-HSA-2172127
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by ALK fusions and activated point mutants R-HSA-9725370
PI-3K cascade:FGFR3 R-HSA-5654710
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by EGFRvIII in Cancer R-HSA-5637812
Downstream signaling of activated FGFR4 R-HSA-5654716
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Insulin receptor R-HSA-74752
Signaling by EGFR R-HSA-177929
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by ALK in cancer R-HSA-9700206
PI3K/AKT Signaling in Cancer R-HSA-2219528
GPCR downstream signalling R-HSA-388396
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-2 family signaling R-HSA-451927
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by FGFR3 in disease R-HSA-5655332
Signaling by ERBB2 KD Mutants R-HSA-9664565
Hemostasis R-HSA-109582
RAC2 GTPase cycle R-HSA-9013404
Disease R-HSA-1643685
CD28 dependent PI3K/Akt signaling R-HSA-389357
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
PI3K Cascade R-HSA-109704
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Signaling by FGFR2 R-HSA-5654738
Interleukin receptor SHC signaling R-HSA-912526
Signaling by VEGF R-HSA-194138
IRS-mediated signalling R-HSA-112399
RAF/MAP kinase cascade R-HSA-5673001
TCR signaling R-HSA-202403
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by Interleukins R-HSA-449147
Signaling by FGFR1 in disease R-HSA-5655302
Metabolism of lipids R-HSA-556833
Nervous system development R-HSA-9675108
RET signaling R-HSA-8853659
FLT3 Signaling R-HSA-9607240
Signaling by NTRK3 (TRKC) R-HSA-9034015
Nephrin family interactions R-HSA-373753
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by FGFR4 R-HSA-5654743
MET activates PI3K/AKT signaling R-HSA-8851907
Signaling by FGFR R-HSA-190236
Signaling by Erythropoietin R-HSA-9006335
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by FGFR3 R-HSA-5654741
Downstream signaling of activated FGFR1 R-HSA-5654687
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NTRKs R-HSA-166520
G alpha (q) signalling events R-HSA-416476
PI-3K cascade:FGFR4 R-HSA-5654720
PI3K/AKT activation R-HSA-198203
Negative regulation of the PI3K/AKT network R-HSA-199418
Regulation of signaling by CBL R-HSA-912631
Signaling by PDGF R-HSA-186797
Platelet activation, signaling and aggregation R-HSA-76002
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by FGFR1 R-HSA-5654736
Signaling by KIT in disease R-HSA-9669938
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by FGFR in disease R-HSA-1226099
FLT3 signaling in disease R-HSA-9682385
DAP12 signaling R-HSA-2424491
Signaling by ERBB4 R-HSA-1236394
Signaling by Rho GTPases R-HSA-194315
Signaling by ERBB2 ECD mutants R-HSA-9665348
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by FGFR2 in disease R-HSA-5655253
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Costimulation by the CD28 family R-HSA-388841
ESR-mediated signaling R-HSA-8939211
PI-3K cascade:FGFR2 R-HSA-5654695
VEGFA-VEGFR2 Pathway R-HSA-4420097
Extra-nuclear estrogen signaling R-HSA-9009391
Immune System R-HSA-168256
Signaling by NTRK2 (TRKB) R-HSA-9006115
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by EGFR in Cancer R-HSA-1643713
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
IGF1R signaling cascade R-HSA-2428924
Activated NTRK3 signals through PI3K R-HSA-9603381
Signal Transduction R-HSA-162582
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Tie2 Signaling R-HSA-210993
Adaptive Immune System R-HSA-1280218
Signaling by FGFR4 in disease R-HSA-5655291
PI-3K cascade:FGFR1 R-HSA-5654689
Metabolism R-HSA-1430728
Downstream TCR signaling R-HSA-202424
MAPK family signaling cascades R-HSA-5683057
PI Metabolism R-HSA-1483255
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Axon guidance R-HSA-422475
Cell-Cell communication R-HSA-1500931
Signaling by NTRK1 (TRKA) R-HSA-187037
Innate Immune System R-HSA-168249
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by ERBB2 in Cancer R-HSA-1227990
Downstream signal transduction R-HSA-186763
GAB1 signalosome R-HSA-180292
Constitutive Signaling by EGFRvIII R-HSA-5637810
Insulin receptor signalling cascade R-HSA-74751
Signaling by FLT3 fusion proteins R-HSA-9703465
PI3K events in ERBB2 signaling R-HSA-1963642
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by MET R-HSA-6806834
Phospholipid metabolism R-HSA-1483257
Signaling by ALK R-HSA-201556
Signaling by PDGFR in disease R-HSA-9671555
Signaling by ERBB2 R-HSA-1227986
CD28 co-stimulation R-HSA-389356
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Cell surface interactions at the vascular wall R-HSA-202733
GPVI-mediated activation cascade R-HSA-114604
Signaling by SCF-KIT R-HSA-1433557
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR3 in disease R-HSA-5655332
Negative regulation of the PI3K/AKT network R-HSA-199418
Nephrin family interactions R-HSA-373753
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by ALK R-HSA-201556
Signaling by FGFR2 in disease R-HSA-5655253
Innate Immune System R-HSA-168249
MET activates PI3K/AKT signaling R-HSA-8851907
RAC1 GTPase cycle R-HSA-9013149
Downstream signaling of activated FGFR4 R-HSA-5654716
FLT3 Signaling R-HSA-9607240
PI-3K cascade:FGFR2 R-HSA-5654695
IRS-related events triggered by IGF1R R-HSA-2428928
Interleukin-2 family signaling R-HSA-451927
Signaling by NTRKs R-HSA-166520
PI-3K cascade:FGFR1 R-HSA-5654689
Signaling by FLT3 fusion proteins R-HSA-9703465
Metabolism R-HSA-1430728
Phospholipid metabolism R-HSA-1483257
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by ERBB4 R-HSA-1236394
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by KIT in disease R-HSA-9669938
TCR signaling R-HSA-202403
Signaling by ERBB2 KD Mutants R-HSA-9664565
Tie2 Signaling R-HSA-210993
GPVI-mediated activation cascade R-HSA-114604
PI-3K cascade:FGFR4 R-HSA-5654720
Intracellular signaling by second messengers R-HSA-9006925
Developmental Biology R-HSA-1266738
GPCR downstream signalling R-HSA-388396
Costimulation by the CD28 family R-HSA-388841
RET signaling R-HSA-8853659
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Downstream signaling of activated FGFR1 R-HSA-5654687
Role of phospholipids in phagocytosis R-HSA-2029485
G alpha (q) signalling events R-HSA-416476
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
GAB1 signalosome R-HSA-180292
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Downstream TCR signaling R-HSA-202424
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by FGFR3 R-HSA-5654741
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Downstream signal transduction R-HSA-186763
PI Metabolism R-HSA-1483255
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by PDGF R-HSA-186797
PI3K events in ERBB2 signaling R-HSA-1963642
RHO GTPase cycle R-HSA-9012999
Regulation of signaling by CBL R-HSA-912631
Signaling by FGFR in disease R-HSA-1226099
Signaling by PDGFR in disease R-HSA-9671555
Hemostasis R-HSA-109582
Signaling by GPCR R-HSA-372790
Cell-Cell communication R-HSA-1500931
ESR-mediated signaling R-HSA-8939211
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by ERBB2 R-HSA-1227986
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Activated NTRK2 signals through PI3K R-HSA-9028335
Interleukin receptor SHC signaling R-HSA-912526
Signaling by MET R-HSA-6806834
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
PI3K/AKT Signaling in Cancer R-HSA-2219528
Synthesis of PIPs at the plasma membrane R-HSA-1660499
FLT3 signaling in disease R-HSA-9682385
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by EGFR R-HSA-177929
Signaling by FGFR1 R-HSA-5654736
Cytokine Signaling in Immune system R-HSA-1280215
Cell surface interactions at the vascular wall R-HSA-202733
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Interleukins R-HSA-449147
Signaling by ERBB2 in Cancer R-HSA-1227990
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
DAP12 signaling R-HSA-2424491
Signaling by NTRK2 (TRKB) R-HSA-9006115
MAPK1/MAPK3 signaling R-HSA-5684996
Insulin receptor signalling cascade R-HSA-74751
Signaling by Insulin receptor R-HSA-74752
Signaling by ERBB2 ECD mutants R-HSA-9665348
Disease R-HSA-1643685
Adaptive Immune System R-HSA-1280218
Signaling by FGFR2 R-HSA-5654738
RAC2 GTPase cycle R-HSA-9013404
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by Rho GTPases R-HSA-194315
RAF/MAP kinase cascade R-HSA-5673001
Metabolism of lipids R-HSA-556833
MAPK family signaling cascades R-HSA-5683057
PI3K/AKT activation R-HSA-198203
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by FGFR4 R-HSA-5654743
Nervous system development R-HSA-9675108
Signal Transduction R-HSA-162582
IRS-mediated signalling R-HSA-112399
PI3K events in ERBB4 signaling R-HSA-1250342
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Erythropoietin R-HSA-9006335
Signaling by FGFR R-HSA-190236
Activated NTRK3 signals through PI3K R-HSA-9603381
Signaling by EGFRvIII in Cancer R-HSA-5637812
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by NTRK3 (TRKC) R-HSA-9034015
PI3K Cascade R-HSA-109704
Signaling by ALK in cancer R-HSA-9700206
Immune System R-HSA-168256
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by VEGF R-HSA-194138
Platelet activation, signaling and aggregation R-HSA-76002
IGF1R signaling cascade R-HSA-2428924
PI-3K cascade:FGFR3 R-HSA-5654710
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
PIP3 activates AKT signaling R-HSA-1257604
DAP12 interactions R-HSA-2172127
Axon guidance R-HSA-422475
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Signaling by SCF-KIT R-HSA-1433557
CD28 co-stimulation R-HSA-389356
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Downstream signaling of activated FGFR3 R-HSA-5654708
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by FGFR in disease R-HSA-1226099
Role of phospholipids in phagocytosis R-HSA-2029485
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by NTRK3 (TRKC) R-HSA-9034015
PI-3K cascade:FGFR1 R-HSA-5654689
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by GPCR R-HSA-372790
Interleukin receptor SHC signaling R-HSA-912526
Signaling by FGFR3 in disease R-HSA-5655332
FGFR1 mutant receptor activation R-HSA-1839124
ESR-mediated signaling R-HSA-8939211
Signaling by Interleukins R-HSA-449147
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Insulin receptor signalling cascade R-HSA-74751
Phospholipid metabolism R-HSA-1483257
Signaling by Insulin receptor R-HSA-74752
RHO GTPase cycle R-HSA-9012999
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
MAPK family signaling cascades R-HSA-5683057
Signaling by KIT in disease R-HSA-9669938
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
DAP12 interactions R-HSA-2172127
FLT3 Signaling R-HSA-9607240
IGF1R signaling cascade R-HSA-2428924
Signaling by ALK in cancer R-HSA-9700206
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by EGFR R-HSA-177929
Regulation of signaling by CBL R-HSA-912631
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
MAPK1/MAPK3 signaling R-HSA-5684996
Developmental Biology R-HSA-1266738
Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905
Adaptive Immune System R-HSA-1280218
Interleukin-2 family signaling R-HSA-451927
Signaling by Erythropoietin R-HSA-9006335
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by NTRKs R-HSA-166520
G alpha (q) signalling events R-HSA-416476
Extra-nuclear estrogen signaling R-HSA-9009391
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Costimulation by the CD28 family R-HSA-388841
Signaling by ERBB2 in Cancer R-HSA-1227990
DAP12 signaling R-HSA-2424491
Signaling by SCF-KIT R-HSA-1433557
Axon guidance R-HSA-422475
Platelet activation, signaling and aggregation R-HSA-76002
Metabolism of lipids R-HSA-556833
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by EGFR in Cancer R-HSA-1643713
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by FGFR2 R-HSA-5654738
Tie2 Signaling R-HSA-210993
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Signaling by EGFRvIII in Cancer R-HSA-5637812
Activated NTRK2 signals through PI3K R-HSA-9028335
Innate Immune System R-HSA-168249
Intracellular signaling by second messengers R-HSA-9006925
Activated NTRK3 signals through PI3K R-HSA-9603381
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by NTRK2 (TRKB) R-HSA-9006115
CD28 co-stimulation R-HSA-389356
GPCR downstream signalling R-HSA-388396
Nephrin family interactions R-HSA-373753
Synthesis of PIPs at the plasma membrane R-HSA-1660499
Signaling by ERBB2 R-HSA-1227986
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by FGFR R-HSA-190236
GAB1 signalosome R-HSA-180292
PI-3K cascade:FGFR2 R-HSA-5654695
Signal Transduction R-HSA-162582
PI3K/AKT Signaling in Cancer R-HSA-2219528
Immune System R-HSA-168256
PI-3K cascade:FGFR4 R-HSA-5654720
Metabolism R-HSA-1430728
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by PDGFR in disease R-HSA-9671555
Hemostasis R-HSA-109582
Signaling by VEGF R-HSA-194138
RET signaling R-HSA-8853659
Signaling by FGFR2 in disease R-HSA-5655253
PI Metabolism R-HSA-1483255
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-HSA-9027276
PI3K events in ERBB4 signaling R-HSA-1250342
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
PIP3 activates AKT signaling R-HSA-1257604
GPVI-mediated activation cascade R-HSA-114604
Signaling by FGFR3 R-HSA-5654741
Signaling by PDGF R-HSA-186797
VEGFA-VEGFR2 Pathway R-HSA-4420097
PI-3K cascade:FGFR3 R-HSA-5654710
CD28 dependent PI3K/Akt signaling R-HSA-389357
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC2 GTPase cycle R-HSA-9013404
Signaling by FGFR1 R-HSA-5654736
FLT3 signaling in disease R-HSA-9682385
Signaling by ERBB4 R-HSA-1236394
RAC1 GTPase cycle R-HSA-9013149
PI3K/AKT activation R-HSA-198203
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by ERBB2 ECD mutants R-HSA-9665348
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
MET activates PI3K/AKT signaling R-HSA-8851907
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by Rho GTPases R-HSA-194315
TCR signaling R-HSA-202403
Cell-Cell communication R-HSA-1500931
Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-512988
Signaling by MET R-HSA-6806834
Signaling by NTRK1 (TRKA) R-HSA-187037
RAF/MAP kinase cascade R-HSA-5673001
Signaling by ALK R-HSA-201556
Signaling by FGFR4 R-HSA-5654743
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Downstream signal transduction R-HSA-186763
IRS-mediated signalling R-HSA-112399
Disease R-HSA-1643685
Downstream TCR signaling R-HSA-202424
Downstream signaling of activated FGFR3 R-HSA-5654708
Nervous system development R-HSA-9675108

Expression Atlas ENSG00000121879
LRG display in Ensembl gene LRG_310
NCBI gene (formerly Entrezgene) 5290
GeneCards 8975
HGNC Symbol HGNC:8975
MIM gene 171834
MIM morbid 619538
UniProtKB Gene Name P42336
WikiGene 5290