Gene: CCND1
Ensembl ID : ENSG00000110092
Description: cyclin D1
Gene Synonyms: BCL1,D11S287E,PRAD1,U21B31
1 APIs:
274 Possible Orthologues:

Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Diseases of mitotic cell cycle R-HSA-9675126
Pre-NOTCH Transcription and Translation R-HSA-1912408
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Chromatin organization R-HSA-4839726
Transcriptional Regulation by VENTX R-HSA-8853884
Generic Transcription Pathway R-HSA-212436
RMTs methylate histone arginines R-HSA-3214858
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Disease R-HSA-1643685
Estrogen-dependent gene expression R-HSA-9018519
Pre-NOTCH Expression and Processing R-HSA-1912422
Cytokine Signaling in Immune system R-HSA-1280215
Extra-nuclear estrogen signaling R-HSA-9009391
Immune System R-HSA-168256
ESR-mediated signaling R-HSA-8939211
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Signaling by Nuclear Receptors R-HSA-9006931
G1 Phase R-HSA-69236
Cyclin D associated events in G1 R-HSA-69231
G1/S Transition R-HSA-69206
Cell Cycle, Mitotic R-HSA-69278
S Phase R-HSA-69242
Mitotic G1 phase and G1/S transition R-HSA-453279
RNA Polymerase II Transcription R-HSA-73857
PTK6 Regulates Cell Cycle R-HSA-8849470
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Cell Cycle R-HSA-1640170
Signaling by NOTCH R-HSA-157118
Signaling by PTK6 R-HSA-8848021
Chromatin modifying enzymes R-HSA-3247509
RUNX3 regulates p14-ARF R-HSA-8951936
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Gene expression (Transcription) R-HSA-74160
RUNX3 regulates WNT signaling R-HSA-8951430
Transcriptional regulation by RUNX2 R-HSA-8878166
Cyclin E associated events during G1/S transition R-HSA-69202
Transcriptional regulation by RUNX1 R-HSA-8878171
Signal Transduction R-HSA-162582
Transcriptional regulation by RUNX3 R-HSA-8878159
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Signaling by Interleukins R-HSA-449147
Disease R-HSA-1643685
Signaling by Nuclear Receptors R-HSA-9006931
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
S Phase R-HSA-69242
Gene expression (Transcription) R-HSA-74160
PTK6 Regulates Cell Cycle R-HSA-8849470
Transcriptional Regulation by VENTX R-HSA-8853884
RMTs methylate histone arginines R-HSA-3214858
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Cell Cycle R-HSA-1640170
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
RUNX3 regulates WNT signaling R-HSA-8951430
Pre-NOTCH Expression and Processing R-HSA-1912422
Transcriptional regulation by RUNX3 R-HSA-8878159
G1 Phase R-HSA-69236
Transcriptional regulation by RUNX1 R-HSA-8878171
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cyclin E associated events during G1/S transition R-HSA-69202
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Signaling by NOTCH R-HSA-157118
RNA Polymerase II Transcription R-HSA-73857
Signaling by PTK6 R-HSA-8848021
G1/S Transition R-HSA-69206
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Immune System R-HSA-168256
Signaling by Interleukins R-HSA-449147
Chromatin modifying enzymes R-HSA-3247509
Pre-NOTCH Transcription and Translation R-HSA-1912408
Cell Cycle, Mitotic R-HSA-69278
Estrogen-dependent gene expression R-HSA-9018519
Extra-nuclear estrogen signaling R-HSA-9009391
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Cyclin D associated events in G1 R-HSA-69231
Chromatin organization R-HSA-4839726
Generic Transcription Pathway R-HSA-212436
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
RUNX3 regulates p14-ARF R-HSA-8951936
Mitotic G1 phase and G1/S transition R-HSA-453279
Signal Transduction R-HSA-162582
ESR-mediated signaling R-HSA-8939211
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of mitotic cell cycle R-HSA-9675126
Transcriptional regulation by RUNX2 R-HSA-8878166
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Chromatin modifying enzymes R-HSA-3247509
S Phase R-HSA-69242
Mitotic G1 phase and G1/S transition R-HSA-453279
RMTs methylate histone arginines R-HSA-3214858
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Transcriptional regulation by RUNX1 R-HSA-8878171
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Transcriptional Regulation by VENTX R-HSA-8853884
ESR-mediated signaling R-HSA-8939211
Transcriptional regulation by RUNX3 R-HSA-8878159
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Diseases of mitotic cell cycle R-HSA-9675126
Generic Transcription Pathway R-HSA-212436
Signaling by Interleukins R-HSA-449147
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Cytokine Signaling in Immune system R-HSA-1280215
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cyclin E associated events during G1/S transition R-HSA-69202
Cyclin D associated events in G1 R-HSA-69231
RUNX3 regulates WNT signaling R-HSA-8951430
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
RUNX3 regulates p14-ARF R-HSA-8951936
Signaling by PTK6 R-HSA-8848021
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
G1 Phase R-HSA-69236
Extra-nuclear estrogen signaling R-HSA-9009391
Estrogen-dependent gene expression R-HSA-9018519
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
RNA Polymerase II Transcription R-HSA-73857
G1/S Transition R-HSA-69206
PTK6 Regulates Cell Cycle R-HSA-8849470
Signaling by NOTCH R-HSA-157118
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
Pre-NOTCH Transcription and Translation R-HSA-1912408
Gene expression (Transcription) R-HSA-74160
Transcriptional regulation by RUNX2 R-HSA-8878166
Disease R-HSA-1643685
Pre-NOTCH Expression and Processing R-HSA-1912422
Chromatin organization R-HSA-4839726
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Cyclin D associated events in G1 R-HSA-69231
ESR-mediated signaling R-HSA-8939211
Cytokine Signaling in Immune system R-HSA-1280215
Immune System R-HSA-168256
RUNX3 regulates p14-ARF R-HSA-8951936
RNA Polymerase II Transcription R-HSA-73857
Mitotic G1 phase and G1/S transition R-HSA-453279
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Transcriptional regulation by RUNX1 R-HSA-8878171
Chromatin organization R-HSA-4839726
RUNX3 regulates WNT signaling R-HSA-8951430
Generic Transcription Pathway R-HSA-212436
Estrogen-dependent gene expression R-HSA-9018519
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Diseases of mitotic cell cycle R-HSA-9675126
RMTs methylate histone arginines R-HSA-3214858
Signaling by Nuclear Receptors R-HSA-9006931
Pre-NOTCH Expression and Processing R-HSA-1912422
Chromatin modifying enzymes R-HSA-3247509
Signaling by NOTCH R-HSA-157118
G1/S Transition R-HSA-69206
S Phase R-HSA-69242
Gene expression (Transcription) R-HSA-74160
PTK6 Regulates Cell Cycle R-HSA-8849470
Disease R-HSA-1643685
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Transcriptional Regulation by VENTX R-HSA-8853884
Extra-nuclear estrogen signaling R-HSA-9009391
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Pre-NOTCH Transcription and Translation R-HSA-1912408
Transcriptional regulation by RUNX2 R-HSA-8878166
G1 Phase R-HSA-69236
Signaling by PTK6 R-HSA-8848021
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cell Cycle, Mitotic R-HSA-69278
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Signal Transduction R-HSA-162582
Cell Cycle R-HSA-1640170
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Cyclin E associated events during G1/S transition R-HSA-69202
Transcriptional regulation by RUNX3 R-HSA-8878159
Signaling by Interleukins R-HSA-449147
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
G1/S Transition R-HSA-69206
PTK6 Regulates Cell Cycle R-HSA-8849470
Estrogen-dependent gene expression R-HSA-9018519
Pre-NOTCH Expression and Processing R-HSA-1912422
Immune System R-HSA-168256
Signaling by Interleukins R-HSA-449147
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Transcriptional Regulation by VENTX R-HSA-8853884
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Gene expression (Transcription) R-HSA-74160
G1 Phase R-HSA-69236
Diseases of mitotic cell cycle R-HSA-9675126
RUNX3 regulates WNT signaling R-HSA-8951430
Mitotic G1 phase and G1/S transition R-HSA-453279
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Transcriptional regulation by RUNX3 R-HSA-8878159
ESR-mediated signaling R-HSA-8939211
RMTs methylate histone arginines R-HSA-3214858
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Disease R-HSA-1643685
RUNX3 regulates p14-ARF R-HSA-8951936
Pre-NOTCH Transcription and Translation R-HSA-1912408
Chromatin modifying enzymes R-HSA-3247509
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Transcriptional regulation by RUNX2 R-HSA-8878166
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Signaling by NOTCH R-HSA-157118
Chromatin organization R-HSA-4839726
Signaling by PTK6 R-HSA-8848021
Transcriptional regulation by RUNX1 R-HSA-8878171
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Signal Transduction R-HSA-162582
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Cyclin D associated events in G1 R-HSA-69231
Signaling by Nuclear Receptors R-HSA-9006931
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
S Phase R-HSA-69242
Extra-nuclear estrogen signaling R-HSA-9009391
Cytokine Signaling in Immune system R-HSA-1280215
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Cyclin E associated events during G1/S transition R-HSA-69202
Generic Transcription Pathway R-HSA-212436
Signaling by Interleukins R-HSA-449147
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by PTK6 R-HSA-8848021
Disease R-HSA-1643685
Transcriptional regulation by RUNX1 R-HSA-8878171
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Signaling by NOTCH R-HSA-157118
Transcriptional regulation by RUNX3 R-HSA-8878159
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Transcriptional Regulation by VENTX R-HSA-8853884
Chromatin organization R-HSA-4839726
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Pre-NOTCH Expression and Processing R-HSA-1912422
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Transcriptional regulation by RUNX2 R-HSA-8878166
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
G1 Phase R-HSA-69236
RUNX3 regulates p14-ARF R-HSA-8951936
S Phase R-HSA-69242
ESR-mediated signaling R-HSA-8939211
Signaling by Nuclear Receptors R-HSA-9006931
Chromatin modifying enzymes R-HSA-3247509
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Immune System R-HSA-168256
Pre-NOTCH Transcription and Translation R-HSA-1912408
RMTs methylate histone arginines R-HSA-3214858
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Cell Cycle, Mitotic R-HSA-69278
G1/S Transition R-HSA-69206
Extra-nuclear estrogen signaling R-HSA-9009391
Cell Cycle R-HSA-1640170
Mitotic G1 phase and G1/S transition R-HSA-453279
Cyclin D associated events in G1 R-HSA-69231
RNA Polymerase II Transcription R-HSA-73857
Diseases of mitotic cell cycle R-HSA-9675126
Estrogen-dependent gene expression R-HSA-9018519
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
RUNX3 regulates WNT signaling R-HSA-8951430
Cyclin E associated events during G1/S transition R-HSA-69202
Gene expression (Transcription) R-HSA-74160
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
PTK6 Regulates Cell Cycle R-HSA-8849470
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Transcriptional regulation by RUNX3 R-HSA-8878159
Signal Transduction R-HSA-162582
RUNX3 regulates WNT signaling R-HSA-8951430
RMTs methylate histone arginines R-HSA-3214858
S Phase R-HSA-69242
G1/S Transition R-HSA-69206
RUNX3 regulates p14-ARF R-HSA-8951936
Cyclin E associated events during G1/S transition R-HSA-69202
Chromatin modifying enzymes R-HSA-3247509
PTK6 Regulates Cell Cycle R-HSA-8849470
Cell Cycle R-HSA-1640170
Signaling by NOTCH R-HSA-157118
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Pre-NOTCH Transcription and Translation R-HSA-1912408
Transcriptional Regulation by VENTX R-HSA-8853884
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Extra-nuclear estrogen signaling R-HSA-9009391
Immune System R-HSA-168256
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Gene expression (Transcription) R-HSA-74160
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Chromatin organization R-HSA-4839726
Generic Transcription Pathway R-HSA-212436
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Diseases of mitotic cell cycle R-HSA-9675126
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Interleukins R-HSA-449147
Transcriptional regulation by RUNX1 R-HSA-8878171
ESR-mediated signaling R-HSA-8939211
Pre-NOTCH Expression and Processing R-HSA-1912422
Transcriptional regulation by RUNX2 R-HSA-8878166
Disease R-HSA-1643685
Mitotic G1 phase and G1/S transition R-HSA-453279
Signaling by PTK6 R-HSA-8848021
Cyclin D associated events in G1 R-HSA-69231
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Cell Cycle, Mitotic R-HSA-69278
RNA Polymerase II Transcription R-HSA-73857
Estrogen-dependent gene expression R-HSA-9018519
Cytokine Signaling in Immune system R-HSA-1280215
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
G1 Phase R-HSA-69236
Cell Cycle R-HSA-1640170
Transcriptional regulation by RUNX2 R-HSA-8878166
Signaling by NOTCH R-HSA-157118
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Interleukins R-HSA-449147
Chromatin organization R-HSA-4839726
Mitotic G1 phase and G1/S transition R-HSA-453279
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Generic Transcription Pathway R-HSA-212436
RUNX3 regulates p14-ARF R-HSA-8951936
Chromatin modifying enzymes R-HSA-3247509
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Transcriptional regulation by RUNX3 R-HSA-8878159
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Disease R-HSA-1643685
Pre-NOTCH Transcription and Translation R-HSA-1912408
RNA Polymerase II Transcription R-HSA-73857
Transcriptional regulation by RUNX1 R-HSA-8878171
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
PTK6 Regulates Cell Cycle R-HSA-8849470
Cell Cycle, Mitotic R-HSA-69278
Gene expression (Transcription) R-HSA-74160
Signaling by Nuclear Receptors R-HSA-9006931
Cyclin D associated events in G1 R-HSA-69231
G1/S Transition R-HSA-69206
RMTs methylate histone arginines R-HSA-3214858
Transcriptional Regulation by VENTX R-HSA-8853884
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Immune System R-HSA-168256
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
S Phase R-HSA-69242
Signaling by PTK6 R-HSA-8848021
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Cyclin E associated events during G1/S transition R-HSA-69202
Signal Transduction R-HSA-162582
Pre-NOTCH Expression and Processing R-HSA-1912422
Estrogen-dependent gene expression R-HSA-9018519
Extra-nuclear estrogen signaling R-HSA-9009391
G1 Phase R-HSA-69236
RUNX3 regulates WNT signaling R-HSA-8951430
Diseases of mitotic cell cycle R-HSA-9675126
ESR-mediated signaling R-HSA-8939211
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Pre-NOTCH Transcription and Translation R-HSA-1912408
Signaling by Nuclear Receptors R-HSA-9006931
Cell Cycle R-HSA-1640170
Signaling by Interleukins R-HSA-449147
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Transcriptional regulation by RUNX1 R-HSA-8878171
Chromatin modifying enzymes R-HSA-3247509
Generic Transcription Pathway R-HSA-212436
Chromatin organization R-HSA-4839726
Cytokine Signaling in Immune system R-HSA-1280215
Transcriptional regulation by RUNX3 R-HSA-8878159
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Mitotic G1 phase and G1/S transition R-HSA-453279
Pre-NOTCH Expression and Processing R-HSA-1912422
Gene expression (Transcription) R-HSA-74160
Estrogen-dependent gene expression R-HSA-9018519
Diseases of mitotic cell cycle R-HSA-9675126
Extra-nuclear estrogen signaling R-HSA-9009391
Disease R-HSA-1643685
Cyclin E associated events during G1/S transition R-HSA-69202
RUNX3 regulates p14-ARF R-HSA-8951936
PTK6 Regulates Cell Cycle R-HSA-8849470
S Phase R-HSA-69242
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
RUNX3 regulates WNT signaling R-HSA-8951430
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Cell Cycle, Mitotic R-HSA-69278
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Interleukin-4 and Interleukin-13 signaling R-HSA-6785807
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
G1 Phase R-HSA-69236
ESR-mediated signaling R-HSA-8939211
Signaling by PTK6 R-HSA-8848021
RNA Polymerase II Transcription R-HSA-73857
G1/S Transition R-HSA-69206
Transcriptional Regulation by VENTX R-HSA-8853884
Signaling by NOTCH R-HSA-157118
Cyclin D associated events in G1 R-HSA-69231
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
RMTs methylate histone arginines R-HSA-3214858
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Transcriptional regulation by RUNX2 R-HSA-8878166
Immune System R-HSA-168256
Signal Transduction R-HSA-162582

Expression Atlas ENSG00000110092
LRG display in Ensembl gene LRG_990
NCBI gene (formerly Entrezgene) 595
GeneCards 1582
HGNC Symbol HGNC:1582
MIM gene 168461
MIM morbid 254500
UniProtKB Gene Name Q6FI00
WikiGene 595
Gene: ERBB2
Ensembl ID : ENSG00000141736
Description: erb-b2 receptor tyrosine kinase 2
Gene Synonyms: C-ERB-2,C-ERB2,CD340,HER-2,HER2,MLN-19,NEU,NGL,P185(ERBB2)
39 APIs:
200 Possible Orthologues:

Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Drug resistance in ERBB2 KD mutants R-HSA-9665230
ERBB2 Regulates Cell Motility R-HSA-6785631
PI3K events in ERBB2 signaling R-HSA-1963642
Disease R-HSA-1643685
Signaling by ERBB2 KD Mutants R-HSA-9664565
Intracellular signaling by second messengers R-HSA-9006925
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
Sema4D in semaphorin signaling R-HSA-400685
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by ERBB2 ECD mutants R-HSA-9665348
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PIP3 activates AKT signaling R-HSA-1257604
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
SHC1 events in ERBB2 signaling R-HSA-1250196
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PLCG1 events in ERBB2 signaling R-HSA-1251932
Signaling by ERBB2 in Cancer R-HSA-1227990
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 R-HSA-1227986
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
GRB2 events in ERBB2 signaling R-HSA-1963640
MAPK1/MAPK3 signaling R-HSA-5684996
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
Generic Transcription Pathway R-HSA-212436
GRB7 events in ERBB2 signaling R-HSA-1306955
Nervous system development R-HSA-9675108
RAF/MAP kinase cascade R-HSA-5673001
RNA Polymerase II Transcription R-HSA-73857
Axon guidance R-HSA-422475
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
MAPK family signaling cascades R-HSA-5683057
Signaling by PTK6 R-HSA-8848021
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
Semaphorin interactions R-HSA-373755
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
PI3K/AKT Signaling in Cancer R-HSA-2219528
Negative regulation of the PI3K/AKT network R-HSA-199418
Developmental Biology R-HSA-1266738
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
MAPK family signaling cascades R-HSA-5683057
PIP3 activates AKT signaling R-HSA-1257604
Developmental Biology R-HSA-1266738
Drug resistance in ERBB2 KD mutants R-HSA-9665230
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
RNA Polymerase II Transcription R-HSA-73857
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by ERBB2 KD Mutants R-HSA-9664565
PI3K events in ERBB2 signaling R-HSA-1963642
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
GRB7 events in ERBB2 signaling R-HSA-1306955
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ERBB2 in Cancer R-HSA-1227990
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
Nervous system development R-HSA-9675108
PI3K/AKT Signaling in Cancer R-HSA-2219528
Generic Transcription Pathway R-HSA-212436
Gene expression (Transcription) R-HSA-74160
Semaphorin interactions R-HSA-373755
Intracellular signaling by second messengers R-HSA-9006925
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
RAF/MAP kinase cascade R-HSA-5673001
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Sema4D in semaphorin signaling R-HSA-400685
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Downregulation of ERBB2 signaling R-HSA-8863795
Disease R-HSA-1643685
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
GRB2 events in ERBB2 signaling R-HSA-1963640
MAPK1/MAPK3 signaling R-HSA-5684996
PLCG1 events in ERBB2 signaling R-HSA-1251932
Axon guidance R-HSA-422475
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by PTK6 R-HSA-8848021
Signal Transduction R-HSA-162582
Negative regulation of the PI3K/AKT network R-HSA-199418
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Signaling by ERBB2 R-HSA-1227986
RAF/MAP kinase cascade R-HSA-5673001
Downregulation of ERBB2 signaling R-HSA-8863795
Signal Transduction R-HSA-162582
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by PTK6 R-HSA-8848021
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by ERBB2 KD Mutants R-HSA-9664565
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Sema4D in semaphorin signaling R-HSA-400685
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by ERBB2 in Cancer R-HSA-1227990
PI3K events in ERBB2 signaling R-HSA-1963642
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Nervous system development R-HSA-9675108
PLCG1 events in ERBB2 signaling R-HSA-1251932
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
RNA Polymerase II Transcription R-HSA-73857
Disease R-HSA-1643685
Signaling by ERBB2 R-HSA-1227986
Generic Transcription Pathway R-HSA-212436
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
MAPK family signaling cascades R-HSA-5683057
Developmental Biology R-HSA-1266738
Signaling by ERBB2 ECD mutants R-HSA-9665348
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Drug resistance in ERBB2 KD mutants R-HSA-9665230
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Axon guidance R-HSA-422475
Gene expression (Transcription) R-HSA-74160
GRB7 events in ERBB2 signaling R-HSA-1306955
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
PI3K/AKT Signaling in Cancer R-HSA-2219528
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
PIP3 activates AKT signaling R-HSA-1257604
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
GRB2 events in ERBB2 signaling R-HSA-1963640
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Intracellular signaling by second messengers R-HSA-9006925
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Semaphorin interactions R-HSA-373755
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
ERBB2 Regulates Cell Motility R-HSA-6785631
PIP3 activates AKT signaling R-HSA-1257604
Nervous system development R-HSA-9675108
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Signal Transduction R-HSA-162582
Downregulation of ERBB2 signaling R-HSA-8863795
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
Sema4D in semaphorin signaling R-HSA-400685
Drug resistance in ERBB2 KD mutants R-HSA-9665230
GRB2 events in ERBB2 signaling R-HSA-1963640
RAF/MAP kinase cascade R-HSA-5673001
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Semaphorin interactions R-HSA-373755
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by ERBB2 in Cancer R-HSA-1227990
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
Developmental Biology R-HSA-1266738
PLCG1 events in ERBB2 signaling R-HSA-1251932
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Gene expression (Transcription) R-HSA-74160
Signaling by ERBB2 ECD mutants R-HSA-9665348
Generic Transcription Pathway R-HSA-212436
MAPK1/MAPK3 signaling R-HSA-5684996
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by ERBB2 R-HSA-1227986
Intracellular signaling by second messengers R-HSA-9006925
Axon guidance R-HSA-422475
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
RNA Polymerase II Transcription R-HSA-73857
PI3K/AKT Signaling in Cancer R-HSA-2219528
GRB7 events in ERBB2 signaling R-HSA-1306955
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SHC1 events in ERBB2 signaling R-HSA-1250196
Disease R-HSA-1643685
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by PTK6 R-HSA-8848021
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
MAPK family signaling cascades R-HSA-5683057
MAPK family signaling cascades R-HSA-5683057
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by PTK6 R-HSA-8848021
ERBB2 Regulates Cell Motility R-HSA-6785631
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF/MAP kinase cascade R-HSA-5673001
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
Developmental Biology R-HSA-1266738
RNA Polymerase II Transcription R-HSA-73857
PIP3 activates AKT signaling R-HSA-1257604
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of the PI3K/AKT network R-HSA-199418
Disease R-HSA-1643685
Signaling by ERBB2 KD Mutants R-HSA-9664565
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Semaphorin interactions R-HSA-373755
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
Axon guidance R-HSA-422475
PI3K/AKT Signaling in Cancer R-HSA-2219528
Intracellular signaling by second messengers R-HSA-9006925
Sema4D in semaphorin signaling R-HSA-400685
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
GRB7 events in ERBB2 signaling R-HSA-1306955
PI3K events in ERBB2 signaling R-HSA-1963642
PLCG1 events in ERBB2 signaling R-HSA-1251932
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
Drug resistance in ERBB2 KD mutants R-HSA-9665230
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by ERBB2 ECD mutants R-HSA-9665348
Downregulation of ERBB2 signaling R-HSA-8863795
Gene expression (Transcription) R-HSA-74160
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Generic Transcription Pathway R-HSA-212436
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Nervous system development R-HSA-9675108
Signaling by ERBB2 in Cancer R-HSA-1227990
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
Signaling by ERBB2 R-HSA-1227986
SHC1 events in ERBB2 signaling R-HSA-1250196
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
ERBB2 Activates PTK6 Signaling R-HSA-8847993
GRB2 events in ERBB2 signaling R-HSA-1963640
Signal Transduction R-HSA-162582
Generic Transcription Pathway R-HSA-212436
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 KD Mutants R-HSA-9664565
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
Sema4D in semaphorin signaling R-HSA-400685
Axon guidance R-HSA-422475
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
GRB7 events in ERBB2 signaling R-HSA-1306955
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PLCG1 events in ERBB2 signaling R-HSA-1251932
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by ERBB2 ECD mutants R-HSA-9665348
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Signaling by PTK6 R-HSA-8848021
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Developmental Biology R-HSA-1266738
Semaphorin interactions R-HSA-373755
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
RAF/MAP kinase cascade R-HSA-5673001
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
MAPK1/MAPK3 signaling R-HSA-5684996
Drug resistance in ERBB2 KD mutants R-HSA-9665230
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
Gene expression (Transcription) R-HSA-74160
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
PIP3 activates AKT signaling R-HSA-1257604
Signaling by ERBB2 R-HSA-1227986
Signaling by ERBB2 in Cancer R-HSA-1227990
PI3K events in ERBB2 signaling R-HSA-1963642
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
Intracellular signaling by second messengers R-HSA-9006925
Gene expression (Transcription) R-HSA-74160
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Axon guidance R-HSA-422475
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by ERBB2 R-HSA-1227986
Sema4D in semaphorin signaling R-HSA-400685
Signaling by ERBB2 in Cancer R-HSA-1227990
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
Semaphorin interactions R-HSA-373755
Drug resistance in ERBB2 KD mutants R-HSA-9665230
Signaling by PTK6 R-HSA-8848021
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
Signaling by ERBB2 KD Mutants R-HSA-9664565
GRB2 events in ERBB2 signaling R-HSA-1963640
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
Generic Transcription Pathway R-HSA-212436
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
SHC1 events in ERBB2 signaling R-HSA-1250196
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by ERBB2 ECD mutants R-HSA-9665348
Disease R-HSA-1643685
Downregulation of ERBB2 signaling R-HSA-8863795
MAPK1/MAPK3 signaling R-HSA-5684996
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
RAF/MAP kinase cascade R-HSA-5673001
Nervous system development R-HSA-9675108
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI3K events in ERBB2 signaling R-HSA-1963642
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
PI3K/AKT Signaling in Cancer R-HSA-2219528
ERBB2 Regulates Cell Motility R-HSA-6785631
GRB7 events in ERBB2 signaling R-HSA-1306955
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
PLCG1 events in ERBB2 signaling R-HSA-1251932
RNA Polymerase II Transcription R-HSA-73857
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
PI3K/AKT Signaling in Cancer R-HSA-2219528
RAF/MAP kinase cascade R-HSA-5673001
Semaphorin interactions R-HSA-373755
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
MAPK family signaling cascades R-HSA-5683057
PLCG1 events in ERBB2 signaling R-HSA-1251932
Axon guidance R-HSA-422475
GRB7 events in ERBB2 signaling R-HSA-1306955
RNA Polymerase II Transcription R-HSA-73857
GRB2 events in ERBB2 signaling R-HSA-1963640
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by ERBB2 in Cancer R-HSA-1227990
Generic Transcription Pathway R-HSA-212436
Signaling by ERBB2 R-HSA-1227986
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
Disease R-HSA-1643685
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
ERBB2 Regulates Cell Motility R-HSA-6785631
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by ERBB2 ECD mutants R-HSA-9665348
Downregulation of ERBB2 signaling R-HSA-8863795
SHC1 events in ERBB2 signaling R-HSA-1250196
PIP3 activates AKT signaling R-HSA-1257604
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Sema4D in semaphorin signaling R-HSA-400685
Gene expression (Transcription) R-HSA-74160
Signaling by PTK6 R-HSA-8848021
Drug resistance in ERBB2 KD mutants R-HSA-9665230
PI3K events in ERBB2 signaling R-HSA-1963642
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Developmental Biology R-HSA-1266738
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
Nervous system development R-HSA-9675108
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signal Transduction R-HSA-162582
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Nervous system development R-HSA-9675108
Generic Transcription Pathway R-HSA-212436
SHC1 events in ERBB2 signaling R-HSA-1250196
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
GRB7 events in ERBB2 signaling R-HSA-1306955
Intracellular signaling by second messengers R-HSA-9006925
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Drug resistance in ERBB2 KD mutants R-HSA-9665230
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Developmental Biology R-HSA-1266738
Signaling by ERBB2 ECD mutants R-HSA-9665348
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
Signaling by ERBB2 R-HSA-1227986
Sema4D in semaphorin signaling R-HSA-400685
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by ERBB2 KD Mutants R-HSA-9664565
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
ERBB2 Regulates Cell Motility R-HSA-6785631
MAPK1/MAPK3 signaling R-HSA-5684996
PI3K events in ERBB2 signaling R-HSA-1963642
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Disease R-HSA-1643685
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
PLCG1 events in ERBB2 signaling R-HSA-1251932
Axon guidance R-HSA-422475
PIP3 activates AKT signaling R-HSA-1257604
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Downregulation of ERBB2 signaling R-HSA-8863795
Semaphorin interactions R-HSA-373755
Signaling by PTK6 R-HSA-8848021
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
RAF/MAP kinase cascade R-HSA-5673001
RNA Polymerase II Transcription R-HSA-73857
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by PTK6 R-HSA-8848021
Drug resistance in ERBB2 KD mutants R-HSA-9665230
GRB7 events in ERBB2 signaling R-HSA-1306955
Downregulation of ERBB2 signaling R-HSA-8863795
PIP3 activates AKT signaling R-HSA-1257604
Resistance of ERBB2 KD mutants to osimertinib R-HSA-9665247
MAPK1/MAPK3 signaling R-HSA-5684996
Resistance of ERBB2 KD mutants to trastuzumab R-HSA-9665233
RNA Polymerase II Transcription R-HSA-73857
Signaling by ERBB2 KD Mutants R-HSA-9664565
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI3K/AKT Signaling in Cancer R-HSA-2219528
Drug-mediated inhibition of ERBB2 signaling R-HSA-9652282
Negative regulation of the PI3K/AKT network R-HSA-199418
Developmental Biology R-HSA-1266738
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Semaphorin interactions R-HSA-373755
Resistance of ERBB2 KD mutants to AEE788 R-HSA-9665250
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Resistance of ERBB2 KD mutants to sapitinib R-HSA-9665244
MAPK family signaling cascades R-HSA-5683057
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Intracellular signaling by second messengers R-HSA-9006925
Sema4D induced cell migration and growth-cone collapse R-HSA-416572
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Drug resistance in ERBB2 TMD/JMD mutants R-HSA-9665737
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by ERBB2 in Cancer R-HSA-1227990
Sema4D in semaphorin signaling R-HSA-400685
Axon guidance R-HSA-422475
Resistance of ERBB2 KD mutants to lapatinib R-HSA-9665251
Nervous system development R-HSA-9675108
Resistance of ERBB2 KD mutants to neratinib R-HSA-9665246
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803
SHC1 events in ERBB2 signaling R-HSA-1250196
RAF/MAP kinase cascade R-HSA-5673001
Generic Transcription Pathway R-HSA-212436
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
PLCG1 events in ERBB2 signaling R-HSA-1251932
Signaling by ERBB2 R-HSA-1227986
Resistance of ERBB2 KD mutants to tesevatinib R-HSA-9665245
Gene expression (Transcription) R-HSA-74160
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Resistance of ERBB2 KD mutants to afatinib R-HSA-9665249
Signal Transduction R-HSA-162582

Expression Atlas ENSG00000141736
LRG display in Ensembl gene LRG_724
NCBI gene (formerly Entrezgene) 2064
GeneCards 3430
HGNC Symbol HGNC:3430
MIM gene 164870
MIM morbid 619465
UniProtKB Gene Name X5DNK3
WikiGene 2064
Gene: MAPK1
Ensembl ID : ENSG00000100030
Description: mitogen-activated protein kinase 1
Gene Synonyms: ERK,ERK2,MAPK2,P41MAPK,PRKM1,PRKM2
6 APIs:
214 Possible Orthologues:

Signaling by MAP2K mutants R-HSA-9652169
Hemostasis R-HSA-109582
MAP kinase activation R-HSA-450294
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Cytokine Signaling in Immune system R-HSA-1280215
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Infection with Mycobacterium tuberculosis R-HSA-9635486
Ca-dependent events R-HSA-111996
Signaling by MAPK mutants R-HSA-9652817
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of FGFR2 signaling R-HSA-5654727
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by Rho GTPases R-HSA-194315
Signaling by TGFB family members R-HSA-9006936
Signaling by FGFR4 R-HSA-5654743
Transcriptional Regulation by NPAS4 R-HSA-9634815
Toll-like Receptor Cascades R-HSA-168898
Signaling by GPCR R-HSA-372790
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Opioid Signalling R-HSA-111885
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Leishmania phagocytosis R-HSA-9664417
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
PLC beta mediated events R-HSA-112043
Signaling by NTRK1 (TRKA) R-HSA-187037
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
MAPK1/MAPK3 signaling R-HSA-5684996
Platelet activation, signaling and aggregation R-HSA-76002
Oxidative Stress Induced Senescence R-HSA-2559580
Negative regulation of MAPK pathway R-HSA-5675221
ERK/MAPK targets R-HSA-198753
Intracellular signaling by second messengers R-HSA-9006925
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by Insulin receptor R-HSA-74752
Post NMDA receptor activation events R-HSA-438064
Recycling pathway of L1 R-HSA-437239
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by RAF1 mutants R-HSA-9656223
Suppression of apoptosis R-HSA-9635465
G-protein mediated events R-HSA-112040
Hemostasis R-HSA-109582
RUNX2 regulates bone development R-HSA-8941326
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling by MAP2K mutants R-HSA-9652169
MyD88-independent TLR4 cascade R-HSA-166166
phospho-PLA2 pathway R-HSA-111995
Parasite infection R-HSA-9664407
PIP3 activates AKT signaling R-HSA-1257604
MAPK family signaling cascades R-HSA-5683057
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Infectious disease R-HSA-5663205
Mitotic Prophase R-HSA-68875
Negative regulation of FGFR3 signaling R-HSA-5654732
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Growth hormone receptor signaling R-HSA-982772
Nervous system development R-HSA-9675108
RNA Polymerase II Transcription R-HSA-73857
ERKs are inactivated R-HSA-202670
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Neuronal System R-HSA-112316
MAPK1 (ERK2) activation R-HSA-112411
Negative regulation of FGFR1 signaling R-HSA-5654726
Neutrophil degranulation R-HSA-6798695
Oncogenic MAPK signaling R-HSA-6802957
Signaling by TGF-beta Receptor Complex R-HSA-170834
Signaling by NODAL R-HSA-1181150
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signal transduction by L1 R-HSA-445144
Signaling by ALK in cancer R-HSA-9700206
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
RAF-independent MAPK1/3 activation R-HSA-112409
Gene expression (Transcription) R-HSA-74160
Regulation of the apoptosome activity R-HSA-9627069
Signaling by Interleukins R-HSA-449147
Signaling by FGFR2 R-HSA-5654738
Frs2-mediated activation R-HSA-170968
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Regulation of HSF1-mediated heat shock response R-HSA-3371453
MyD88 dependent cascade initiated on endosome R-HSA-975155
Prolonged ERK activation events R-HSA-169893
L1CAM interactions R-HSA-373760
Innate Immune System R-HSA-168249
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
G alpha (i) signalling events R-HSA-418594
PTEN Regulation R-HSA-6807070
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signalling to ERKs R-HSA-187687
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Formation of apoptosome R-HSA-111458
ESR-mediated signaling R-HSA-8939211
Insulin receptor signalling cascade R-HSA-74751
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Axon guidance R-HSA-422475
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Regulation of PTEN gene transcription R-HSA-8943724
Oncogene Induced Senescence R-HSA-2559585
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Activation of the AP-1 family of transcription factors R-HSA-450341
Signaling by Activin R-HSA-1502540
FCERI mediated MAPK activation R-HSA-2871796
RAF/MAP kinase cascade R-HSA-5673001
Intrinsic Pathway for Apoptosis R-HSA-109606
Transmission across Chemical Synapses R-HSA-112315
Generic Transcription Pathway R-HSA-212436
NCAM signaling for neurite out-growth R-HSA-375165
Signaling downstream of RAS mutants R-HSA-9649948
Cytochrome c-mediated apoptotic response R-HSA-111461
Signaling by FGFR3 R-HSA-5654741
Signaling by RAS mutants R-HSA-6802949
Apoptosis R-HSA-109581
Immune System R-HSA-168256
Negative feedback regulation of MAPK pathway R-HSA-5674499
Spry regulation of FGF signaling R-HSA-1295596
Developmental Biology R-HSA-1266738
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by NTRKs R-HSA-166520
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
RHO GTPase Effectors R-HSA-195258
Cellular response to heat stress R-HSA-3371556
Signal attenuation R-HSA-74749
Transcriptional regulation by RUNX2 R-HSA-8878166
Leishmania infection R-HSA-9658195
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by FGFR1 R-HSA-5654736
Programmed Cell Death R-HSA-5357801
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
M Phase R-HSA-68886
G alpha (q) signalling events R-HSA-416476
RSK activation R-HSA-444257
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Negative regulation of the PI3K/AKT network R-HSA-199418
Negative regulation of FGFR4 signaling R-HSA-5654733
Signal Transduction R-HSA-162582
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Cellular Senescence R-HSA-2559583
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Cell Cycle, Mitotic R-HSA-69278
FCGR3A-mediated phagocytosis R-HSA-9664422
MAP kinase activation R-HSA-450294
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Response of Mtb to phagocytosis R-HSA-9637690
GPCR downstream signalling R-HSA-388396
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Nuclear Receptors R-HSA-9006931
NPAS4 regulates expression of target genes R-HSA-9768919
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by FGFR R-HSA-190236
MAP2K and MAPK activation R-HSA-5674135
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Cell Cycle R-HSA-1640170
Disease R-HSA-1643685
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Apoptotic factor-mediated response R-HSA-111471
Oxidative Stress Induced Senescence R-HSA-2559580
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by NTRK1 (TRKA) R-HSA-187037
phospho-PLA2 pathway R-HSA-111995
Signal Transduction R-HSA-162582
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
MyD88 cascade initiated on plasma membrane R-HSA-975871
Transmission across Chemical Synapses R-HSA-112315
Intracellular signaling by second messengers R-HSA-9006925
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
NCAM signaling for neurite out-growth R-HSA-375165
Negative regulation of the PI3K/AKT network R-HSA-199418
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by ALK in cancer R-HSA-9700206
Oncogenic MAPK signaling R-HSA-6802957
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Cytochrome c-mediated apoptotic response R-HSA-111461
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
G-protein mediated events R-HSA-112040
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Post NMDA receptor activation events R-HSA-438064
Extra-nuclear estrogen signaling R-HSA-9009391
Cellular responses to stimuli R-HSA-8953897
Apoptotic factor-mediated response R-HSA-111471
Ca-dependent events R-HSA-111996
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Mitotic Prophase R-HSA-68875
Axon guidance R-HSA-422475
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MAPK1/MAPK3 signaling R-HSA-5684996
Neutrophil degranulation R-HSA-6798695
Insulin receptor signalling cascade R-HSA-74751
Negative feedback regulation of MAPK pathway R-HSA-5674499
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Signaling by Insulin receptor R-HSA-74752
MyD88-independent TLR4 cascade R-HSA-166166
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Transcriptional regulation by RUNX2 R-HSA-8878166
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Hemostasis R-HSA-109582
Response of Mtb to phagocytosis R-HSA-9637690
Immune System R-HSA-168256
Generic Transcription Pathway R-HSA-212436
Opioid Signalling R-HSA-111885
Infection with Mycobacterium tuberculosis R-HSA-9635486
Leishmania infection R-HSA-9658195
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Cellular response to heat stress R-HSA-3371556
Signaling by NTRKs R-HSA-166520
Signaling by Activin R-HSA-1502540
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
FCGR3A-mediated phagocytosis R-HSA-9664422
Apoptosis R-HSA-109581
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by TGFB family members R-HSA-9006936
RUNX2 regulates bone development R-HSA-8941326
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
G alpha (i) signalling events R-HSA-418594
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR4 R-HSA-5654743
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signal transduction by L1 R-HSA-445144
GPCR downstream signalling R-HSA-388396
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR2 signaling R-HSA-5654727
Infectious disease R-HSA-5663205
MyD88 dependent cascade initiated on endosome R-HSA-975155
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Developmental Biology R-HSA-1266738
Regulation of PTEN gene transcription R-HSA-8943724
ERKs are inactivated R-HSA-202670
Signaling by NODAL R-HSA-1181150
RSK activation R-HSA-444257
Activation of the AP-1 family of transcription factors R-HSA-450341
RNA Polymerase II Transcription R-HSA-73857
MAPK family signaling cascades R-HSA-5683057
Signaling by MAP2K mutants R-HSA-9652169
Prolonged ERK activation events R-HSA-169893
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Regulation of the apoptosome activity R-HSA-9627069
PLC beta mediated events R-HSA-112043
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Leishmania phagocytosis R-HSA-9664417
ERK/MAPK targets R-HSA-198753
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
Signal attenuation R-HSA-74749
Growth hormone receptor signaling R-HSA-982772
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Interleukin-17 signaling R-HSA-448424
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by MAPK mutants R-HSA-9652817
Oncogene Induced Senescence R-HSA-2559585
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Recycling pathway of L1 R-HSA-437239
ESR-mediated signaling R-HSA-8939211
Disease R-HSA-1643685
Parasite infection R-HSA-9664407
Negative regulation of FGFR3 signaling R-HSA-5654732
Transcriptional Regulation by NPAS4 R-HSA-9634815
Signaling by FGFR2 R-HSA-5654738
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
PTEN Regulation R-HSA-6807070
Signaling by Rho GTPases R-HSA-194315
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
M Phase R-HSA-68886
Innate Immune System R-HSA-168249
RHO GTPase Effectors R-HSA-195258
MAP kinase activation R-HSA-450294
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Frs2-mediated activation R-HSA-170968
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by TGF-beta Receptor Complex R-HSA-170834
Signaling by FGFR1 R-HSA-5654736
Cellular responses to stress R-HSA-2262752
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nervous system development R-HSA-9675108
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Cell Cycle, Mitotic R-HSA-69278
FCERI mediated MAPK activation R-HSA-2871796
MAP2K and MAPK activation R-HSA-5674135
Suppression of apoptosis R-HSA-9635465
RAF/MAP kinase cascade R-HSA-5673001
Formation of apoptosome R-HSA-111458
MAPK1 (ERK2) activation R-HSA-112411
Neuronal System R-HSA-112316
Cellular Senescence R-HSA-2559583
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Intrinsic Pathway for Apoptosis R-HSA-109606
Signalling to ERKs R-HSA-187687
Programmed Cell Death R-HSA-5357801
Signaling by RAS mutants R-HSA-6802949
Cell Cycle R-HSA-1640170
Signaling by Interleukins R-HSA-449147
Gene expression (Transcription) R-HSA-74160
NPAS4 regulates expression of target genes R-HSA-9768919
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Signaling by FGFR R-HSA-190236
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
L1CAM interactions R-HSA-373760
PIP3 activates AKT signaling R-HSA-1257604
Toll-like Receptor Cascades R-HSA-168898
Signaling by FGFR3 R-HSA-5654741
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Oncogenic MAPK signaling R-HSA-6802957
Suppression of apoptosis R-HSA-9635465
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
ESR-mediated signaling R-HSA-8939211
Regulation of the apoptosome activity R-HSA-9627069
Cytokine Signaling in Immune system R-HSA-1280215
ERKs are inactivated R-HSA-202670
PLC beta mediated events R-HSA-112043
Oncogene Induced Senescence R-HSA-2559585
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
GPCR downstream signalling R-HSA-388396
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by RAF1 mutants R-HSA-9656223
Infectious disease R-HSA-5663205
Transcriptional regulation by RUNX2 R-HSA-8878166
PIP3 activates AKT signaling R-HSA-1257604
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Opioid Signalling R-HSA-111885
Transmission across Chemical Synapses R-HSA-112315
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR2 R-HSA-5654738
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Insulin receptor signalling cascade R-HSA-74751
Prolonged ERK activation events R-HSA-169893
Parasite infection R-HSA-9664407
G alpha (i) signalling events R-HSA-418594
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
RUNX2 regulates bone development R-HSA-8941326
Signaling by GPCR R-HSA-372790
Toll-like Receptor Cascades R-HSA-168898
Transcriptional Regulation by NPAS4 R-HSA-9634815
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
L1CAM interactions R-HSA-373760
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Programmed Cell Death R-HSA-5357801
Frs2-mediated activation R-HSA-170968
Signaling downstream of RAS mutants R-HSA-9649948
FCERI mediated MAPK activation R-HSA-2871796
NPAS4 regulates expression of target genes R-HSA-9768919
Signaling by FGFR R-HSA-190236
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Recycling pathway of L1 R-HSA-437239
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
MAPK1/MAPK3 signaling R-HSA-5684996
Cell Cycle R-HSA-1640170
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Gene expression (Transcription) R-HSA-74160
Signal transduction by L1 R-HSA-445144
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Leishmania infection R-HSA-9658195
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
PTEN Regulation R-HSA-6807070
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Apoptotic factor-mediated response R-HSA-111471
Signal attenuation R-HSA-74749
Response of Mtb to phagocytosis R-HSA-9637690
Signaling by ALK in cancer R-HSA-9700206
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Immune System R-HSA-168256
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cytochrome c-mediated apoptotic response R-HSA-111461
RAF-independent MAPK1/3 activation R-HSA-112409
Ca-dependent events R-HSA-111996
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Post NMDA receptor activation events R-HSA-438064
Hemostasis R-HSA-109582
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Innate Immune System R-HSA-168249
Oxidative Stress Induced Senescence R-HSA-2559580
Signaling by Rho GTPases R-HSA-194315
Signaling by Interleukins R-HSA-449147
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Signaling by FGFR3 R-HSA-5654741
MAP2K and MAPK activation R-HSA-5674135
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Intracellular signaling by second messengers R-HSA-9006925
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Activation of the AP-1 family of transcription factors R-HSA-450341
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by RAS mutants R-HSA-6802949
Regulation of PTEN gene transcription R-HSA-8943724
Platelet activation, signaling and aggregation R-HSA-76002
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
M Phase R-HSA-68886
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Formation of apoptosome R-HSA-111458
Negative regulation of FGFR2 signaling R-HSA-5654727
Disease R-HSA-1643685
MAP kinase activation R-HSA-450294
Mitotic Prophase R-HSA-68875
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Apoptosis R-HSA-109581
Signaling by Activin R-HSA-1502540
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
G alpha (q) signalling events R-HSA-416476
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
G-protein mediated events R-HSA-112040
FCGR3A-mediated phagocytosis R-HSA-9664422
MyD88 cascade initiated on plasma membrane R-HSA-975871
Developmental Biology R-HSA-1266738
Growth hormone receptor signaling R-HSA-982772
Neuronal System R-HSA-112316
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Axon guidance R-HSA-422475
Infection with Mycobacterium tuberculosis R-HSA-9635486
Extra-nuclear estrogen signaling R-HSA-9009391
Signalling to ERKs R-HSA-187687
RHO GTPase Effectors R-HSA-195258
Cell Cycle, Mitotic R-HSA-69278
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Neutrophil degranulation R-HSA-6798695
RNA Polymerase II Transcription R-HSA-73857
Signaling by Insulin receptor R-HSA-74752
Negative regulation of FGFR4 signaling R-HSA-5654733
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Negative feedback regulation of MAPK pathway R-HSA-5674499
Negative regulation of the PI3K/AKT network R-HSA-199418
Generic Transcription Pathway R-HSA-212436
phospho-PLA2 pathway R-HSA-111995
Signaling by Nuclear Receptors R-HSA-9006931
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Spry regulation of FGF signaling R-HSA-1295596
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling by NODAL R-HSA-1181150
Cellular responses to stimuli R-HSA-8953897
MAPK1 (ERK2) activation R-HSA-112411
Signaling by TGFB family members R-HSA-9006936
RSK activation R-HSA-444257
Cellular response to heat stress R-HSA-3371556
Cellular responses to stress R-HSA-2262752
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by TGF-beta Receptor Complex R-HSA-170834
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
ERK/MAPK targets R-HSA-198753
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR4 R-HSA-5654743
Signaling by MAPK mutants R-HSA-9652817
Signaling by FGFR1 R-HSA-5654736
Leishmania phagocytosis R-HSA-9664417
NCAM signaling for neurite out-growth R-HSA-375165
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Negative regulation of FGFR3 signaling R-HSA-5654732
Nervous system development R-HSA-9675108
Interleukin-17 signaling R-HSA-448424
Signal Transduction R-HSA-162582
Cellular Senescence R-HSA-2559583
Negative regulation of MAPK pathway R-HSA-5675221
Advanced glycosylation endproduct receptor signaling R-HSA-879415
RSK activation R-HSA-444257
G alpha (i) signalling events R-HSA-418594
Cellular responses to stimuli R-HSA-8953897
RUNX2 regulates bone development R-HSA-8941326
Developmental Biology R-HSA-1266738
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Regulation of PTEN gene transcription R-HSA-8943724
ERK/MAPK targets R-HSA-198753
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Oncogenic MAPK signaling R-HSA-6802957
Platelet activation, signaling and aggregation R-HSA-76002
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Apoptosis R-HSA-109581
Negative regulation of FGFR3 signaling R-HSA-5654732
Activation of the AP-1 family of transcription factors R-HSA-450341
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NODAL R-HSA-1181150
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by Nuclear Receptors R-HSA-9006931
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR4 R-HSA-5654743
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Growth hormone receptor signaling R-HSA-982772
Signaling by ALK in cancer R-HSA-9700206
Negative regulation of MAPK pathway R-HSA-5675221
phospho-PLA2 pathway R-HSA-111995
Oncogene Induced Senescence R-HSA-2559585
Negative feedback regulation of MAPK pathway R-HSA-5674499
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Cell Cycle R-HSA-1640170
MAP2K and MAPK activation R-HSA-5674135
Neuronal System R-HSA-112316
MyD88 dependent cascade initiated on endosome R-HSA-975155
Recycling pathway of L1 R-HSA-437239
Signaling by FGFR3 R-HSA-5654741
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Axon guidance R-HSA-422475
Insulin receptor signalling cascade R-HSA-74751
RAF-independent MAPK1/3 activation R-HSA-112409
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by Rho GTPases R-HSA-194315
Cell Cycle, Mitotic R-HSA-69278
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Cytochrome c-mediated apoptotic response R-HSA-111461
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Negative regulation of FGFR4 signaling R-HSA-5654733
ERKs are inactivated R-HSA-202670
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Infectious disease R-HSA-5663205
Signaling by FGFR R-HSA-190236
Cellular Senescence R-HSA-2559583
FCGR3A-mediated phagocytosis R-HSA-9664422
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
ESR-mediated signaling R-HSA-8939211
Cellular responses to stress R-HSA-2262752
Innate Immune System R-HSA-168249
MAP kinase activation R-HSA-450294
Transcriptional regulation by RUNX2 R-HSA-8878166
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling downstream of RAS mutants R-HSA-9649948
Programmed Cell Death R-HSA-5357801
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Gene expression (Transcription) R-HSA-74160
Spry regulation of FGF signaling R-HSA-1295596
Signaling by Interleukins R-HSA-449147
MyD88 cascade initiated on plasma membrane R-HSA-975871
Post NMDA receptor activation events R-HSA-438064
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
GPCR downstream signalling R-HSA-388396
Parasite infection R-HSA-9664407
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
L1CAM interactions R-HSA-373760
Signaling by FGFR2 R-HSA-5654738
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by NTRK1 (TRKA) R-HSA-187037
Transmission across Chemical Synapses R-HSA-112315
Neutrophil degranulation R-HSA-6798695
Cytokine Signaling in Immune system R-HSA-1280215
RAF/MAP kinase cascade R-HSA-5673001
Opioid Signalling R-HSA-111885
Mitotic Prophase R-HSA-68875
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Toll-like Receptor Cascades R-HSA-168898
Signal Transduction R-HSA-162582
RHO GTPase Effectors R-HSA-195258
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by RAF1 mutants R-HSA-9656223
Apoptotic factor-mediated response R-HSA-111471
Signaling by TGFB family members R-HSA-9006936
Regulation of the apoptosome activity R-HSA-9627069
Leishmania phagocytosis R-HSA-9664417
Signaling by MAP2K mutants R-HSA-9652169
MAPK family signaling cascades R-HSA-5683057
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
RNA Polymerase II Transcription R-HSA-73857
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by FGFR1 R-HSA-5654736
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Frs2-mediated activation R-HSA-170968
NPAS4 regulates expression of target genes R-HSA-9768919
Infection with Mycobacterium tuberculosis R-HSA-9635486
Formation of apoptosome R-HSA-111458
Ca-dependent events R-HSA-111996
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Immune System R-HSA-168256
M Phase R-HSA-68886
PLC beta mediated events R-HSA-112043
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
MyD88-independent TLR4 cascade R-HSA-166166
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Advanced glycosylation endproduct receptor signaling R-HSA-879415
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Transcriptional Regulation by NPAS4 R-HSA-9634815
PTEN Regulation R-HSA-6807070
G alpha (q) signalling events R-HSA-416476
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Cellular response to heat stress R-HSA-3371556
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Suppression of apoptosis R-HSA-9635465
Signaling by MAPK mutants R-HSA-9652817
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Signaling by GPCR R-HSA-372790
Signaling by Insulin receptor R-HSA-74752
Leishmania infection R-HSA-9658195
Signal transduction by L1 R-HSA-445144
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
Oxidative Stress Induced Senescence R-HSA-2559580
Negative regulation of FGFR2 signaling R-HSA-5654727
G-protein mediated events R-HSA-112040
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRKs R-HSA-166520
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by Activin R-HSA-1502540
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signal attenuation R-HSA-74749
Signalling to ERKs R-HSA-187687
Signaling by TGF-beta Receptor Complex R-HSA-170834
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
MAPK1 (ERK2) activation R-HSA-112411
Negative regulation of FGFR1 signaling R-HSA-5654726
FCERI mediated MAPK activation R-HSA-2871796
MAPK1/MAPK3 signaling R-HSA-5684996
Response of Mtb to phagocytosis R-HSA-9637690
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Nervous system development R-HSA-9675108
Generic Transcription Pathway R-HSA-212436
PIP3 activates AKT signaling R-HSA-1257604
Cytochrome c-mediated apoptotic response R-HSA-111461
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Regulation of PTEN gene transcription R-HSA-8943724
Signaling by GPCR R-HSA-372790
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RUNX2 regulates bone development R-HSA-8941326
Signaling by MAP2K mutants R-HSA-9652169
RAF/MAP kinase cascade R-HSA-5673001
Cell Cycle, Mitotic R-HSA-69278
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling by TGF-beta Receptor Complex R-HSA-170834
Apoptosis R-HSA-109581
Gene expression (Transcription) R-HSA-74160
Transmission across Chemical Synapses R-HSA-112315
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Ca-dependent events R-HSA-111996
Suppression of apoptosis R-HSA-9635465
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Oxidative Stress Induced Senescence R-HSA-2559580
Neuronal System R-HSA-112316
Cellular response to heat stress R-HSA-3371556
Platelet activation, signaling and aggregation R-HSA-76002
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Negative regulation of MAPK pathway R-HSA-5675221
Formation of apoptosome R-HSA-111458
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by NTRKs R-HSA-166520
Signaling by RAS mutants R-HSA-6802949
MAP kinase activation R-HSA-450294
Signaling by ALK fusions and activated point mutants R-HSA-9725370
MAPK1/MAPK3 signaling R-HSA-5684996
RSK activation R-HSA-444257
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Programmed Cell Death R-HSA-5357801
Signal attenuation R-HSA-74749
Infection with Mycobacterium tuberculosis R-HSA-9635486
Neutrophil degranulation R-HSA-6798695
Signaling by FGFR3 R-HSA-5654741
Prolonged ERK activation events R-HSA-169893
Growth hormone receptor signaling R-HSA-982772
G-protein mediated events R-HSA-112040
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Generic Transcription Pathway R-HSA-212436
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
MAPK1 (ERK2) activation R-HSA-112411
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NODAL R-HSA-1181150
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Regulation of the apoptosome activity R-HSA-9627069
Insulin receptor signalling cascade R-HSA-74751
Signaling by FGFR4 R-HSA-5654743
MAPK family signaling cascades R-HSA-5683057
Signaling by RAF1 mutants R-HSA-9656223
Signaling downstream of RAS mutants R-HSA-9649948
Leishmania phagocytosis R-HSA-9664417
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
M Phase R-HSA-68886
Oncogenic MAPK signaling R-HSA-6802957
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by Rho GTPases R-HSA-194315
Extra-nuclear estrogen signaling R-HSA-9009391
MyD88-independent TLR4 cascade R-HSA-166166
Oncogene Induced Senescence R-HSA-2559585
Cellular responses to stress R-HSA-2262752
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signal transduction by L1 R-HSA-445144
Leishmania infection R-HSA-9658195
Frs2-mediated activation R-HSA-170968
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
PLC beta mediated events R-HSA-112043
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
ERK/MAPK targets R-HSA-198753
Signaling by Activin R-HSA-1502540
MAP2K and MAPK activation R-HSA-5674135
Nervous system development R-HSA-9675108
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Signaling by Nuclear Receptors R-HSA-9006931
Negative regulation of the PI3K/AKT network R-HSA-199418
RAF-independent MAPK1/3 activation R-HSA-112409
FCERI mediated MAPK activation R-HSA-2871796
Innate Immune System R-HSA-168249
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Interleukin-17 signaling R-HSA-448424
Disease R-HSA-1643685
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Signaling by FGFR2 R-HSA-5654738
Cytokine Signaling in Immune system R-HSA-1280215
RNA Polymerase II Transcription R-HSA-73857
Infectious disease R-HSA-5663205
phospho-PLA2 pathway R-HSA-111995
Intracellular signaling by second messengers R-HSA-9006925
Transcriptional Regulation by NPAS4 R-HSA-9634815
Mitotic Prophase R-HSA-68875
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Recycling pathway of L1 R-HSA-437239
Cellular Senescence R-HSA-2559583
Signaling by NTRK1 (TRKA) R-HSA-187037
Intrinsic Pathway for Apoptosis R-HSA-109606
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
RHO GTPase Effectors R-HSA-195258
PTEN Regulation R-HSA-6807070
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signalling to ERKs R-HSA-187687
Activation of the AP-1 family of transcription factors R-HSA-450341
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
MyD88 cascade initiated on plasma membrane R-HSA-975871
G alpha (q) signalling events R-HSA-416476
Signaling by FGFR R-HSA-190236
NPAS4 regulates expression of target genes R-HSA-9768919
Signaling by Insulin receptor R-HSA-74752
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Hemostasis R-HSA-109582
Signaling by MAPK mutants R-HSA-9652817
ESR-mediated signaling R-HSA-8939211
Post NMDA receptor activation events R-HSA-438064
Cell Cycle R-HSA-1640170
Parasite infection R-HSA-9664407
Signaling by FGFR1 R-HSA-5654736
Opioid Signalling R-HSA-111885
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
FCGR3A-mediated phagocytosis R-HSA-9664422
Negative regulation of FGFR2 signaling R-HSA-5654727
Apoptotic factor-mediated response R-HSA-111471
Signaling by ALK in cancer R-HSA-9700206
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by TGFB family members R-HSA-9006936
Immune System R-HSA-168256
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
L1CAM interactions R-HSA-373760
GPCR downstream signalling R-HSA-388396
Transcriptional regulation by RUNX2 R-HSA-8878166
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Developmental Biology R-HSA-1266738
Axon guidance R-HSA-422475
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Cellular responses to stimuli R-HSA-8953897
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by Interleukins R-HSA-449147
Response of Mtb to phagocytosis R-HSA-9637690
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
ERKs are inactivated R-HSA-202670
RUNX2 regulates osteoblast differentiation R-HSA-8940973
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
Intracellular signaling by second messengers R-HSA-9006925
MyD88 cascade initiated on plasma membrane R-HSA-975871
Leishmania infection R-HSA-9658195
Prolonged ERK activation events R-HSA-169893
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
phospho-PLA2 pathway R-HSA-111995
Programmed Cell Death R-HSA-5357801
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Interleukins R-HSA-449147
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signalling to ERKs R-HSA-187687
Signaling by MAP2K mutants R-HSA-9652169
Signaling by GPCR R-HSA-372790
Signal attenuation R-HSA-74749
MAPK family signaling cascades R-HSA-5683057
Cellular responses to stimuli R-HSA-8953897
Cell Cycle, Mitotic R-HSA-69278
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ERKs are inactivated R-HSA-202670
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Cytochrome c-mediated apoptotic response R-HSA-111461
GPCR downstream signalling R-HSA-388396
FCERI mediated MAPK activation R-HSA-2871796
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by FGFR1 R-HSA-5654736
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Negative regulation of MAPK pathway R-HSA-5675221
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MAPK1/MAPK3 signaling R-HSA-5684996
Suppression of apoptosis R-HSA-9635465
Cellular response to heat stress R-HSA-3371556
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Negative regulation of FGFR1 signaling R-HSA-5654726
MAP2K and MAPK activation R-HSA-5674135
Immune System R-HSA-168256
Interleukin-17 signaling R-HSA-448424
Signaling by RAF1 mutants R-HSA-9656223
MAPK1 (ERK2) activation R-HSA-112411
Signaling by BRAF and RAF1 fusions R-HSA-6802952
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by TGF-beta Receptor Complex R-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Infection with Mycobacterium tuberculosis R-HSA-9635486
Toll-like Receptor Cascades R-HSA-168898
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Axon guidance R-HSA-422475
Neutrophil degranulation R-HSA-6798695
Leishmania phagocytosis R-HSA-9664417
PTEN Regulation R-HSA-6807070
Regulation of PTEN gene transcription R-HSA-8943724
Post NMDA receptor activation events R-HSA-438064
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by TGFB family members R-HSA-9006936
Signaling by MAPK mutants R-HSA-9652817
Apoptotic factor-mediated response R-HSA-111471
Frs2-mediated activation R-HSA-170968
Signaling by Rho GTPases R-HSA-194315
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Transmission across Chemical Synapses R-HSA-112315
Gene expression (Transcription) R-HSA-74160
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nervous system development R-HSA-9675108
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Negative regulation of the PI3K/AKT network R-HSA-199418
Generic Transcription Pathway R-HSA-212436
Neuronal System R-HSA-112316
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signal transduction by L1 R-HSA-445144
RSK activation R-HSA-444257
NCAM signaling for neurite out-growth R-HSA-375165
Ca-dependent events R-HSA-111996
Signaling by FGFR R-HSA-190236
Disease R-HSA-1643685
ESR-mediated signaling R-HSA-8939211
Formation of apoptosome R-HSA-111458
NPAS4 regulates expression of target genes R-HSA-9768919
Oncogenic MAPK signaling R-HSA-6802957
Oncogene Induced Senescence R-HSA-2559585
ERK/MAPK targets R-HSA-198753
Signaling by FGFR4 R-HSA-5654743
Opioid Signalling R-HSA-111885
Transcriptional Regulation by NPAS4 R-HSA-9634815
Signaling by FGFR3 R-HSA-5654741
MyD88-independent TLR4 cascade R-HSA-166166
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Cellular responses to stress R-HSA-2262752
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling by RAS mutants R-HSA-6802949
Intrinsic Pathway for Apoptosis R-HSA-109606
G-protein mediated events R-HSA-112040
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
PLC beta mediated events R-HSA-112043
Signaling by NTRKs R-HSA-166520
Growth hormone receptor signaling R-HSA-982772
Parasite infection R-HSA-9664407
Signaling by NTRK1 (TRKA) R-HSA-187037
Developmental Biology R-HSA-1266738
FCGR3A-mediated phagocytosis R-HSA-9664422
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
RHO GTPase Effectors R-HSA-195258
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
M Phase R-HSA-68886
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by NODAL R-HSA-1181150
Signal Transduction R-HSA-162582
Oxidative Stress Induced Senescence R-HSA-2559580
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by Nuclear Receptors R-HSA-9006931
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Cellular Senescence R-HSA-2559583
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by FGFR2 R-HSA-5654738
Recycling pathway of L1 R-HSA-437239
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of FGFR2 signaling R-HSA-5654727
Infectious disease R-HSA-5663205
Spry regulation of FGF signaling R-HSA-1295596
Mitotic Prophase R-HSA-68875
Innate Immune System R-HSA-168249
Hemostasis R-HSA-109582
Signaling by Activin R-HSA-1502540
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Regulation of HSF1-mediated heat shock response R-HSA-3371453
G alpha (q) signalling events R-HSA-416476
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
RAF-independent MAPK1/3 activation R-HSA-112409
MyD88 dependent cascade initiated on endosome R-HSA-975155
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Cell Cycle R-HSA-1640170
Regulation of the apoptosome activity R-HSA-9627069
RNA Polymerase II Transcription R-HSA-73857
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
L1CAM interactions R-HSA-373760
Activation of the AP-1 family of transcription factors R-HSA-450341
G alpha (i) signalling events R-HSA-418594
Insulin receptor signalling cascade R-HSA-74751
Response of Mtb to phagocytosis R-HSA-9637690
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Apoptosis R-HSA-109581
Signaling by Insulin receptor R-HSA-74752
Signaling by ALK in cancer R-HSA-9700206
Transcriptional regulation by RUNX2 R-HSA-8878166
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
RUNX2 regulates bone development R-HSA-8941326
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Opioid Signalling R-HSA-111885
Signaling by RAF1 mutants R-HSA-9656223
Transmission across Chemical Synapses R-HSA-112315
MAP2K and MAPK activation R-HSA-5674135
Axon guidance R-HSA-422475
Signaling by FGFR1 R-HSA-5654736
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
FCGR3A-mediated phagocytosis R-HSA-9664422
RAF/MAP kinase cascade R-HSA-5673001
Insulin receptor signalling cascade R-HSA-74751
Cellular responses to stress R-HSA-2262752
Signaling by FGFR2 R-HSA-5654738
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Negative regulation of FGFR4 signaling R-HSA-5654733
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Growth hormone receptor signaling R-HSA-982772
M Phase R-HSA-68886
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Spry regulation of FGF signaling R-HSA-1295596
Signaling by RAS mutants R-HSA-6802949
MAPK1/MAPK3 signaling R-HSA-5684996
MyD88-independent TLR4 cascade R-HSA-166166
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Frs2-mediated activation R-HSA-170968
Cellular Senescence R-HSA-2559583
Interleukin-17 signaling R-HSA-448424
Prolonged ERK activation events R-HSA-169893
Negative regulation of MAPK pathway R-HSA-5675221
Negative regulation of the PI3K/AKT network R-HSA-199418
Regulation of PTEN gene transcription R-HSA-8943724
Transcriptional regulation by RUNX2 R-HSA-8878166
Transcriptional Regulation by NPAS4 R-HSA-9634815
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NODAL R-HSA-1181150
Negative regulation of FGFR1 signaling R-HSA-5654726
Immune System R-HSA-168256
Recycling pathway of L1 R-HSA-437239
Developmental Biology R-HSA-1266738
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
phospho-PLA2 pathway R-HSA-111995
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Neutrophil degranulation R-HSA-6798695
MAP kinase activation R-HSA-450294
Infection with Mycobacterium tuberculosis R-HSA-9635486
Signaling by Rho GTPases R-HSA-194315
Intracellular signaling by second messengers R-HSA-9006925
RUNX2 regulates bone development R-HSA-8941326
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Nuclear Receptors R-HSA-9006931
Generic Transcription Pathway R-HSA-212436
Signal attenuation R-HSA-74749
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by NTRK1 (TRKA) R-HSA-187037
Parasite infection R-HSA-9664407
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by FGFR R-HSA-190236
Oxidative Stress Induced Senescence R-HSA-2559580
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
G-protein mediated events R-HSA-112040
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
RAF-independent MAPK1/3 activation R-HSA-112409
L1CAM interactions R-HSA-373760
Response of Mtb to phagocytosis R-HSA-9637690
Activation of NMDA receptors and postsynaptic events R-HSA-442755
GPCR downstream signalling R-HSA-388396
Regulation of HSF1-mediated heat shock response R-HSA-3371453
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by Interleukins R-HSA-449147
Signalling to ERKs R-HSA-187687
Signaling by MAPK mutants R-HSA-9652817
MAPK family signaling cascades R-HSA-5683057
RNA Polymerase II Transcription R-HSA-73857
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Hemostasis R-HSA-109582
Signaling by GPCR R-HSA-372790
ERKs are inactivated R-HSA-202670
Mitotic Prophase R-HSA-68875
Suppression of apoptosis R-HSA-9635465
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88 cascade initiated on plasma membrane R-HSA-975871
Disease R-HSA-1643685
Oncogenic MAPK signaling R-HSA-6802957
Regulation of the apoptosome activity R-HSA-9627069
Infectious disease R-HSA-5663205
Programmed Cell Death R-HSA-5357801
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Negative regulation of FGFR2 signaling R-HSA-5654727
Innate Immune System R-HSA-168249
Toll-like Receptor Cascades R-HSA-168898
Cytochrome c-mediated apoptotic response R-HSA-111461
Formation of apoptosome R-HSA-111458
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Signaling by ALK in cancer R-HSA-9700206
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Cellular responses to stimuli R-HSA-8953897
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Ca-dependent events R-HSA-111996
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Leishmania phagocytosis R-HSA-9664417
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
PIP3 activates AKT signaling R-HSA-1257604
ERK/MAPK targets R-HSA-198753
Signaling by TGFB family members R-HSA-9006936
PLC beta mediated events R-HSA-112043
Nervous system development R-HSA-9675108
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by NTRKs R-HSA-166520
Signaling by TGF-beta Receptor Complex R-HSA-170834
Apoptotic factor-mediated response R-HSA-111471
Oncogene Induced Senescence R-HSA-2559585
Signal transduction by L1 R-HSA-445144
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by FGFR3 R-HSA-5654741
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Gene expression (Transcription) R-HSA-74160
Cell Cycle, Mitotic R-HSA-69278
MyD88 dependent cascade initiated on endosome R-HSA-975155
Negative feedback regulation of MAPK pathway R-HSA-5674499
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
RHO GTPase Effectors R-HSA-195258
FCERI mediated MAPK activation R-HSA-2871796
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Signaling by Activin R-HSA-1502540
Signaling by MAP2K mutants R-HSA-9652169
Post NMDA receptor activation events R-HSA-438064
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Cellular response to heat stress R-HSA-3371556
RSK activation R-HSA-444257
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Leishmania infection R-HSA-9658195
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Signaling by Insulin receptor R-HSA-74752
Activation of the AP-1 family of transcription factors R-HSA-450341
Platelet activation, signaling and aggregation R-HSA-76002
Cell Cycle R-HSA-1640170
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Apoptosis R-HSA-109581
G alpha (i) signalling events R-HSA-418594
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
ESR-mediated signaling R-HSA-8939211
Extra-nuclear estrogen signaling R-HSA-9009391
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
PTEN Regulation R-HSA-6807070
NPAS4 regulates expression of target genes R-HSA-9768919
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling downstream of RAS mutants R-HSA-9649948
MAPK1 (ERK2) activation R-HSA-112411
Signaling by FGFR4 R-HSA-5654743
Neuronal System R-HSA-112316
Regulation of the apoptosome activity R-HSA-9627069
Signaling by FGFR4 R-HSA-5654743
Oncogenic MAPK signaling R-HSA-6802957
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signal transduction by L1 R-HSA-445144
Negative regulation of FGFR4 signaling R-HSA-5654733
G alpha (i) signalling events R-HSA-418594
Infectious disease R-HSA-5663205
Transmission across Chemical Synapses R-HSA-112315
Activation of the AP-1 family of transcription factors R-HSA-450341
PIP3 activates AKT signaling R-HSA-1257604
Signaling by RAS mutants R-HSA-6802949
Post NMDA receptor activation events R-HSA-438064
PTEN Regulation R-HSA-6807070
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
M Phase R-HSA-68886
Infection with Mycobacterium tuberculosis R-HSA-9635486
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Leishmania phagocytosis R-HSA-9664417
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Signaling by FGFR1 R-HSA-5654736
Signaling by BRAF and RAF1 fusions R-HSA-6802952
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Insulin receptor R-HSA-74752
MAPK1 (ERK2) activation R-HSA-112411
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by Activin R-HSA-1502540
MAP kinase activation R-HSA-450294
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Cell Cycle, Mitotic R-HSA-69278
Signaling by TGFB family members R-HSA-9006936
ERKs are inactivated R-HSA-202670
Recycling pathway of L1 R-HSA-437239
G-protein mediated events R-HSA-112040
Intracellular signaling by second messengers R-HSA-9006925
Extra-nuclear estrogen signaling R-HSA-9009391
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
RSK activation R-HSA-444257
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
L1CAM interactions R-HSA-373760
Transcriptional Regulation by NPAS4 R-HSA-9634815
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Regulation of PTEN gene transcription R-HSA-8943724
Ca-dependent events R-HSA-111996
Hemostasis R-HSA-109582
Cytokine Signaling in Immune system R-HSA-1280215
Regulation of HSF1-mediated heat shock response R-HSA-3371453
GPCR downstream signalling R-HSA-388396
Axon guidance R-HSA-422475
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Innate Immune System R-HSA-168249
Cellular Senescence R-HSA-2559583
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by MAP2K mutants R-HSA-9652169
Signaling by NODAL R-HSA-1181150
Signaling by NTRKs R-HSA-166520
Apoptotic factor-mediated response R-HSA-111471
Cellular responses to stimuli R-HSA-8953897
Signaling by FGFR R-HSA-190236
Signal Transduction R-HSA-162582
Signaling by Rho GTPases R-HSA-194315
Neuronal System R-HSA-112316
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Negative regulation of FGFR3 signaling R-HSA-5654732
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Gene expression (Transcription) R-HSA-74160
Cellular responses to stress R-HSA-2262752
Mitotic Prophase R-HSA-68875
Formation of apoptosome R-HSA-111458
Programmed Cell Death R-HSA-5357801
NCAM signaling for neurite out-growth R-HSA-375165
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Apoptosis R-HSA-109581
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by RAF1 mutants R-HSA-9656223
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Growth hormone receptor signaling R-HSA-982772
Intrinsic Pathway for Apoptosis R-HSA-109606
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
FCGR3A-mediated phagocytosis R-HSA-9664422
Platelet activation, signaling and aggregation R-HSA-76002
MAPK family signaling cascades R-HSA-5683057
Transcriptional regulation by RUNX2 R-HSA-8878166
Signaling by GPCR R-HSA-372790
ERK/MAPK targets R-HSA-198753
RUNX2 regulates bone development R-HSA-8941326
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by Interleukins R-HSA-449147
Negative regulation of FGFR1 signaling R-HSA-5654726
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Opioid Signalling R-HSA-111885
Signal attenuation R-HSA-74749
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Neutrophil degranulation R-HSA-6798695
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
RHO GTPase Effectors R-HSA-195258
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Immune System R-HSA-168256
FCERI mediated MAPK activation R-HSA-2871796
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
MyD88 dependent cascade initiated on endosome R-HSA-975155
Disease R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by FGFR3 R-HSA-5654741
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
ESR-mediated signaling R-HSA-8939211
Parasite infection R-HSA-9664407
phospho-PLA2 pathway R-HSA-111995
Signalling to ERKs R-HSA-187687
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling downstream of RAS mutants R-HSA-9649948
NPAS4 regulates expression of target genes R-HSA-9768919
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Generic Transcription Pathway R-HSA-212436
Frs2-mediated activation R-HSA-170968
Leishmania infection R-HSA-9658195
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
MyD88-independent TLR4 cascade R-HSA-166166
RAF/MAP kinase cascade R-HSA-5673001
Oxidative Stress Induced Senescence R-HSA-2559580
Negative regulation of FGFR2 signaling R-HSA-5654727
Nervous system development R-HSA-9675108
MyD88 cascade initiated on plasma membrane R-HSA-975871
Oncogene Induced Senescence R-HSA-2559585
Prolonged ERK activation events R-HSA-169893
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Cellular response to heat stress R-HSA-3371556
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Negative regulation of MAPK pathway R-HSA-5675221
PLC beta mediated events R-HSA-112043
Signaling by ALK in cancer R-HSA-9700206
Toll-like Receptor Cascades R-HSA-168898
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR2 R-HSA-5654738
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAP2K and MAPK activation R-HSA-5674135
Signaling by MAPK mutants R-HSA-9652817
Response of Mtb to phagocytosis R-HSA-9637690
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
RNA Polymerase II Transcription R-HSA-73857
Interleukin-17 signaling R-HSA-448424
Cell Cycle R-HSA-1640170
Suppression of apoptosis R-HSA-9635465
RAF-independent MAPK1/3 activation R-HSA-112409
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
G alpha (q) signalling events R-HSA-416476
Cytochrome c-mediated apoptotic response R-HSA-111461
Signaling by TGF-beta Receptor Complex R-HSA-170834
Insulin receptor signalling cascade R-HSA-74751
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR3 R-HSA-5654741
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
PLC beta mediated events R-HSA-112043
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Opioid Signalling R-HSA-111885
Infection with Mycobacterium tuberculosis R-HSA-9635486
RAF-independent MAPK1/3 activation R-HSA-112409
Cell Cycle, Mitotic R-HSA-69278
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by MAPK mutants R-HSA-9652817
G alpha (q) signalling events R-HSA-416476
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Immune System R-HSA-168256
Hemostasis R-HSA-109582
Neutrophil degranulation R-HSA-6798695
NPAS4 regulates expression of target genes R-HSA-9768919
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Post NMDA receptor activation events R-HSA-438064
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Oncogene Induced Senescence R-HSA-2559585
Signaling by Interleukins R-HSA-449147
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by GPCR R-HSA-372790
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Response of Mtb to phagocytosis R-HSA-9637690
ERKs are inactivated R-HSA-202670
Ca-dependent events R-HSA-111996
MyD88-independent TLR4 cascade R-HSA-166166
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Signal Transduction R-HSA-162582
NCAM signaling for neurite out-growth R-HSA-375165
Activation of the AP-1 family of transcription factors R-HSA-450341
Regulation of the apoptosome activity R-HSA-9627069
Signaling by Insulin receptor R-HSA-74752
Formation of apoptosome R-HSA-111458
Cellular Senescence R-HSA-2559583
Advanced glycosylation endproduct receptor signaling R-HSA-879415
G-protein mediated events R-HSA-112040
ERK/MAPK targets R-HSA-198753
Innate Immune System R-HSA-168249
Cell Cycle R-HSA-1640170
Growth hormone receptor signaling R-HSA-982772
Signaling by FGFR1 R-HSA-5654736
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
PIP3 activates AKT signaling R-HSA-1257604
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Gene expression (Transcription) R-HSA-74160
MAPK1/MAPK3 signaling R-HSA-5684996
RHO GTPase Effectors R-HSA-195258
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by Rho GTPases R-HSA-194315
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by RAS mutants R-HSA-6802949
RNA Polymerase II Transcription R-HSA-73857
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
FCERI mediated MAPK activation R-HSA-2871796
RAF/MAP kinase cascade R-HSA-5673001
Signaling by MAP2K mutants R-HSA-9652169
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Oncogenic MAPK signaling R-HSA-6802957
Cellular responses to stimuli R-HSA-8953897
Developmental Biology R-HSA-1266738
FCGR3A-mediated phagocytosis R-HSA-9664422
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by RAF1 mutants R-HSA-9656223
Signaling by FGFR4 R-HSA-5654743
Leishmania infection R-HSA-9658195
Spry regulation of FGF signaling R-HSA-1295596
Generic Transcription Pathway R-HSA-212436
Recycling pathway of L1 R-HSA-437239
Interleukin-17 signaling R-HSA-448424
ESR-mediated signaling R-HSA-8939211
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Negative regulation of the PI3K/AKT network R-HSA-199418
Regulation of PTEN gene transcription R-HSA-8943724
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Cellular response to heat stress R-HSA-3371556
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Toll-like Receptor Cascades R-HSA-168898
Apoptotic factor-mediated response R-HSA-111471
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Infectious disease R-HSA-5663205
Signaling by Activin R-HSA-1502540
MAPK family signaling cascades R-HSA-5683057
Signaling by ALK in cancer R-HSA-9700206
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of MAPK pathway R-HSA-5675221
Frs2-mediated activation R-HSA-170968
RSK activation R-HSA-444257
Intracellular signaling by second messengers R-HSA-9006925
Programmed Cell Death R-HSA-5357801
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Apoptosis R-HSA-109581
Signalling to ERKs R-HSA-187687
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
L1CAM interactions R-HSA-373760
Parasite infection R-HSA-9664407
Prolonged ERK activation events R-HSA-169893
Extra-nuclear estrogen signaling R-HSA-9009391
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by FGFR2 R-HSA-5654738
Platelet activation, signaling and aggregation R-HSA-76002
Axon guidance R-HSA-422475
Disease R-HSA-1643685
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Oxidative Stress Induced Senescence R-HSA-2559580
Suppression of apoptosis R-HSA-9635465
Signaling by NODAL R-HSA-1181150
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Signaling by Nuclear Receptors R-HSA-9006931
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Leishmania phagocytosis R-HSA-9664417
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
PTEN Regulation R-HSA-6807070
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Cellular responses to stress R-HSA-2262752
Signal transduction by L1 R-HSA-445144
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
GPCR downstream signalling R-HSA-388396
Cytochrome c-mediated apoptotic response R-HSA-111461
Insulin receptor signalling cascade R-HSA-74751
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Nervous system development R-HSA-9675108
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Neuronal System R-HSA-112316
Transcriptional Regulation by NPAS4 R-HSA-9634815
RUNX2 regulates bone development R-HSA-8941326
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by TGF-beta Receptor Complex R-HSA-170834
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
Transmission across Chemical Synapses R-HSA-112315
Mitotic Prophase R-HSA-68875
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
MyD88 dependent cascade initiated on endosome R-HSA-975155
Signaling by NTRKs R-HSA-166520
Transcriptional regulation by RUNX2 R-HSA-8878166
Intrinsic Pathway for Apoptosis R-HSA-109606
Signal attenuation R-HSA-74749
Negative regulation of FGFR3 signaling R-HSA-5654732
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
phospho-PLA2 pathway R-HSA-111995
MAP kinase activation R-HSA-450294
Signaling by NTRK1 (TRKA) R-HSA-187037
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by FGFR R-HSA-190236
G alpha (i) signalling events R-HSA-418594
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
MAPK1 (ERK2) activation R-HSA-112411
Signaling by TGFB family members R-HSA-9006936
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
M Phase R-HSA-68886
ERK/MAPK targets R-HSA-198753
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
Negative regulation of FGFR2 signaling R-HSA-5654727
RHO GTPase Effectors R-HSA-195258
Developmental Biology R-HSA-1266738
Oncogenic MAPK signaling R-HSA-6802957
Signaling by FGFR1 R-HSA-5654736
Signal Transduction R-HSA-162582
Regulation of PTEN gene transcription R-HSA-8943724
MAPK1 (ERK2) activation R-HSA-112411
Negative regulation of MAPK pathway R-HSA-5675221
MyD88 cascade initiated on plasma membrane R-HSA-975871
Ca-dependent events R-HSA-111996
Neutrophil degranulation R-HSA-6798695
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Insulin receptor signalling cascade R-HSA-74751
MAPK family signaling cascades R-HSA-5683057
Signaling by Rho GTPases R-HSA-194315
MAP kinase activation R-HSA-450294
Signaling by FGFR2 R-HSA-5654738
Transcriptional regulation by RUNX2 R-HSA-8878166
Leishmania infection R-HSA-9658195
RSK activation R-HSA-444257
Signaling by NTRKs R-HSA-166520
Regulation of HSF1-mediated heat shock response R-HSA-3371453
Cellular response to heat stress R-HSA-3371556
Signaling by NODAL R-HSA-1181150
Negative feedback regulation of MAPK pathway R-HSA-5674499
Gene expression (Transcription) R-HSA-74160
Cell Cycle, Mitotic R-HSA-69278
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR4 R-HSA-5654743
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by Insulin receptor R-HSA-74752
L1CAM interactions R-HSA-373760
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Intracellular signaling by second messengers R-HSA-9006925
MyD88-independent TLR4 cascade R-HSA-166166
Intrinsic Pathway for Apoptosis R-HSA-109606
FCERI mediated MAPK activation R-HSA-2871796
Cellular responses to stress R-HSA-2262752
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
NCAM signaling for neurite out-growth R-HSA-375165
Apoptosis R-HSA-109581
Signaling by FGFR3 R-HSA-5654741
Signaling by RAS mutants R-HSA-6802949
Growth hormone receptor signaling R-HSA-982772
RNA Polymerase II Transcription R-HSA-73857
Leishmania phagocytosis R-HSA-9664417
Interleukin-17 signaling R-HSA-448424
Apoptotic factor-mediated response R-HSA-111471
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nervous system development R-HSA-9675108
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Frs2-mediated activation R-HSA-170968
Cell Cycle R-HSA-1640170
Signaling by NTRK1 (TRKA) R-HSA-187037
ESR-mediated signaling R-HSA-8939211
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Transmission across Chemical Synapses R-HSA-112315
Signaling downstream of RAS mutants R-HSA-9649948
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Prolonged ERK activation events R-HSA-169893
Regulation of the apoptosome activity R-HSA-9627069
Cellular responses to stimuli R-HSA-8953897
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Signaling by FGFR R-HSA-190236
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Extra-nuclear estrogen signaling R-HSA-9009391
Infection with Mycobacterium tuberculosis R-HSA-9635486
G alpha (q) signalling events R-HSA-416476
Opioid Signalling R-HSA-111885
Negative regulation of FGFR3 signaling R-HSA-5654732
Signal transduction by L1 R-HSA-445144
Suppression of apoptosis R-HSA-9635465
Activation of the AP-1 family of transcription factors R-HSA-450341
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
MAPK1/MAPK3 signaling R-HSA-5684996
Generic Transcription Pathway R-HSA-212436
Signaling by Interleukins R-HSA-449147
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Oxidative Stress Induced Senescence R-HSA-2559580
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Programmed Cell Death R-HSA-5357801
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signalling to ERKs R-HSA-187687
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
Disease R-HSA-1643685
phospho-PLA2 pathway R-HSA-111995
GPCR downstream signalling R-HSA-388396
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Mitotic Prophase R-HSA-68875
Immune System R-HSA-168256
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Platelet activation, signaling and aggregation R-HSA-76002
Spry regulation of FGF signaling R-HSA-1295596
Signaling by MAPK mutants R-HSA-9652817
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
RUNX2 regulates bone development R-HSA-8941326
Cytokine Signaling in Immune system R-HSA-1280215
Infectious disease R-HSA-5663205
NPAS4 regulates expression of target genes R-HSA-9768919
Response of Mtb to phagocytosis R-HSA-9637690
ERKs are inactivated R-HSA-202670
Negative regulation of FGFR1 signaling R-HSA-5654726
MyD88 dependent cascade initiated on endosome R-HSA-975155
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
Innate Immune System R-HSA-168249
Transcriptional Regulation by NPAS4 R-HSA-9634815
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Neuronal System R-HSA-112316
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Axon guidance R-HSA-422475
Cellular Senescence R-HSA-2559583
PIP3 activates AKT signaling R-HSA-1257604
G-protein mediated events R-HSA-112040
Signaling by TGFB family members R-HSA-9006936
Formation of apoptosome R-HSA-111458
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling by RAF1 mutants R-HSA-9656223
Signaling by TGF-beta Receptor Complex R-HSA-170834
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by Activin R-HSA-1502540
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Parasite infection R-HSA-9664407
Signaling by MAP2K mutants R-HSA-9652169
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Signaling by ALK in cancer R-HSA-9700206
FCGR3A-mediated phagocytosis R-HSA-9664422
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Negative regulation of the PI3K/AKT network R-HSA-199418
MAP2K and MAPK activation R-HSA-5674135
Signal attenuation R-HSA-74749
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Cytochrome c-mediated apoptotic response R-HSA-111461
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by Nuclear Receptors R-HSA-9006931
Hemostasis R-HSA-109582
G alpha (i) signalling events R-HSA-418594
RAF/MAP kinase cascade R-HSA-5673001
Toll-like Receptor Cascades R-HSA-168898
Post NMDA receptor activation events R-HSA-438064
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Oncogene Induced Senescence R-HSA-2559585
PLC beta mediated events R-HSA-112043
Signaling by GPCR R-HSA-372790
M Phase R-HSA-68886
Recycling pathway of L1 R-HSA-437239
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
PTEN Regulation R-HSA-6807070
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Hemostasis R-HSA-109582
Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926
ERKs are inactivated R-HSA-202670
Neuronal System R-HSA-112316
Neutrophil degranulation R-HSA-6798695
MyD88-independent TLR4 cascade R-HSA-166166
Negative regulation of FGFR1 signaling R-HSA-5654726
Toll-like Receptor Cascades R-HSA-168898
Signaling by TGF-beta Receptor Complex R-HSA-170834
M Phase R-HSA-68886
RUNX2 regulates osteoblast differentiation R-HSA-8940973
Negative regulation of FGFR4 signaling R-HSA-5654733
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Disease R-HSA-1643685
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Negative regulation of the PI3K/AKT network R-HSA-199418
Oxidative Stress Induced Senescence R-HSA-2559580
Signaling by NTRKs R-HSA-166520
Cellular Senescence R-HSA-2559583
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
MAPK family signaling cascades R-HSA-5683057
Cytochrome c-mediated apoptotic response R-HSA-111461
Intrinsic Pathway for Apoptosis R-HSA-109606
Regulation of PTEN gene transcription R-HSA-8943724
Signaling by TGFB family members R-HSA-9006936
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Cellular response to heat stress R-HSA-3371556
Insulin receptor signalling cascade R-HSA-74751
Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Transmission across Chemical Synapses R-HSA-112315
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Axon guidance R-HSA-422475
FCERI mediated MAPK activation R-HSA-2871796
PIP3 activates AKT signaling R-HSA-1257604
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Spry regulation of FGF signaling R-HSA-1295596
Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795
FCGR3A-mediated phagocytosis R-HSA-9664422
Signaling by FGFR3 R-HSA-5654741
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Extra-nuclear estrogen signaling R-HSA-9009391
Leishmania infection R-HSA-9658195
Oncogenic MAPK signaling R-HSA-6802957
RAF/MAP kinase cascade R-HSA-5673001
PLC beta mediated events R-HSA-112043
Signaling by ALK fusions and activated point mutants R-HSA-9725370
Infection with Mycobacterium tuberculosis R-HSA-9635486
ERK/MAPK targets R-HSA-198753
RHO GTPases Activate NADPH Oxidases R-HSA-5668599
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signal attenuation R-HSA-74749
Activation of the AP-1 family of transcription factors R-HSA-450341
Signaling by FGFR1 R-HSA-5654736
RHO GTPase Effectors R-HSA-195258
Transcriptional regulation by RUNX2 R-HSA-8878166
Signal transduction by L1 R-HSA-445144
Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658
Nuclear events stimulated by ALK signaling in cancer R-HSA-9725371
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Mitotic Prophase R-HSA-68875
Growth hormone receptor signaling R-HSA-982772
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Ca-dependent events R-HSA-111996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAF1 mutants R-HSA-9656223
Leishmania phagocytosis R-HSA-9664417
Signal Transduction R-HSA-162582
Cellular responses to stimuli R-HSA-8953897
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RUNX2 regulates bone development R-HSA-8941326
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by Interleukins R-HSA-449147
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by NODAL R-HSA-1181150
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Apoptotic factor-mediated response R-HSA-111471
Gene expression (Transcription) R-HSA-74160
phospho-PLA2 pathway R-HSA-111995
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Nervous system development R-HSA-9675108
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
MAPK1/MAPK3 signaling R-HSA-5684996
Cellular responses to stress R-HSA-2262752
Intracellular signaling by second messengers R-HSA-9006925
Regulation of the apoptosome activity R-HSA-9627069
Suppression of apoptosis R-HSA-9635465
Cell Cycle R-HSA-1640170
Oncogene Induced Senescence R-HSA-2559585
Recycling pathway of L1 R-HSA-437239
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by MAPK mutants R-HSA-9652817
Signaling by FGFR2 R-HSA-5654738
RNA Polymerase II Transcription R-HSA-73857
GPCR downstream signalling R-HSA-388396
Signaling by MAP2K mutants R-HSA-9652169
MyD88 cascade initiated on plasma membrane R-HSA-975871
MyD88 dependent cascade initiated on endosome R-HSA-975155
Parasite infection R-HSA-9664407
PTEN Regulation R-HSA-6807070
Frs2-mediated activation R-HSA-170968
RAF-independent MAPK1/3 activation R-HSA-112409
Post NMDA receptor activation events R-HSA-438064
Signaling by Nuclear Receptors R-HSA-9006931
NPAS4 regulates expression of target genes R-HSA-9768919
RSK activation R-HSA-444257
G alpha (i) signalling events R-HSA-418594
Generic Transcription Pathway R-HSA-212436
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by FGFR R-HSA-190236
Response of Mtb to phagocytosis R-HSA-9637690
Programmed Cell Death R-HSA-5357801
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by FGFR4 R-HSA-5654743
Signaling by Rho GTPases R-HSA-194315
Signaling by GPCR R-HSA-372790
Negative regulation of FGFR3 signaling R-HSA-5654732
G alpha (q) signalling events R-HSA-416476
Signalling to ERKs R-HSA-187687
Signaling by Insulin receptor R-HSA-74752
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAP2K and MAPK activation R-HSA-5674135
Signaling by Activin R-HSA-1502540
Infectious disease R-HSA-5663205
ESR-mediated signaling R-HSA-8939211
L1CAM interactions R-HSA-373760
Negative regulation of MAPK pathway R-HSA-5675221
Opioid Signalling R-HSA-111885
Innate Immune System R-HSA-168249
Activation of NMDA receptors and postsynaptic events R-HSA-442755
RHO GTPases Activate WASPs and WAVEs R-HSA-5663213
G-protein mediated events R-HSA-112040
Immune System R-HSA-168256
Cell Cycle, Mitotic R-HSA-69278
Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482
Apoptosis R-HSA-109581
Developmental Biology R-HSA-1266738
MAP kinase activation R-HSA-450294
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Regulation of HSF1-mediated heat shock response R-HSA-3371453
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Platelet activation, signaling and aggregation R-HSA-76002
MAPK1 (ERK2) activation R-HSA-112411
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Formation of apoptosome R-HSA-111458
Signaling by ALK in cancer R-HSA-9700206
Prolonged ERK activation events R-HSA-169893
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Nuclear Events (kinase and transcription factor activation) R-HSA-198725
Signaling downstream of RAS mutants R-HSA-9649948
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Negative regulation of FGFR2 signaling R-HSA-5654727
Transcriptional Regulation by NPAS4 R-HSA-9634815
Signaling by RAS mutants R-HSA-6802949

Expression Atlas ENSG00000100030
LRG display in Ensembl gene LRG_786
NCBI gene (formerly Entrezgene) 5594
GeneCards 6871
HGNC Symbol HGNC:6871
MIM gene 176948
MIM morbid 619087
UniProtKB Gene Name Q1HBJ4
WikiGene 5594
Gene: TGFBR1
Ensembl ID : ENSG00000106799
Description: transforming growth factor beta receptor 1
Gene Synonyms: ACVRLK4,ALK-5,ALK5,ESS1,MSSE,TBR-I,TBRI
2 APIs:
236 Possible Orthologues:

Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Signaling by TGFB family members R-HSA-9006936
Post-translational protein modification R-HSA-597592
TGFBR1 KD Mutants in Cancer R-HSA-3656532
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
UCH proteinases R-HSA-5689603
Signal Transduction R-HSA-162582
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Ub-specific processing proteases R-HSA-5689880
Metabolism of proteins R-HSA-392499
Deubiquitination R-HSA-5688426
Disease R-HSA-1643685
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signaling by TGFB family members R-HSA-9006936
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Ub-specific processing proteases R-HSA-5689880
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Disease R-HSA-1643685
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signal Transduction R-HSA-162582
Deubiquitination R-HSA-5688426
Metabolism of proteins R-HSA-392499
UCH proteinases R-HSA-5689603
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Post-translational protein modification R-HSA-597592
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Disease R-HSA-1643685
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signal Transduction R-HSA-162582
Ub-specific processing proteases R-HSA-5689880
Deubiquitination R-HSA-5688426
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Metabolism of proteins R-HSA-392499
TGFBR1 KD Mutants in Cancer R-HSA-3656532
TGF-beta receptor signaling activates SMADs R-HSA-2173789
UCH proteinases R-HSA-5689603
Post-translational protein modification R-HSA-597592
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Signaling by TGFB family members R-HSA-9006936
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Deubiquitination R-HSA-5688426
Ub-specific processing proteases R-HSA-5689880
Disease R-HSA-1643685
Signaling by TGFB family members R-HSA-9006936
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Signal Transduction R-HSA-162582
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Metabolism of proteins R-HSA-392499
UCH proteinases R-HSA-5689603
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Post-translational protein modification R-HSA-597592
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Downregulation of TGF-beta receptor signaling R-HSA-2173788
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Deubiquitination R-HSA-5688426
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
UCH proteinases R-HSA-5689603
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Ub-specific processing proteases R-HSA-5689880
Signaling by TGFB family members R-HSA-9006936
Post-translational protein modification R-HSA-597592
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TGF-beta receptor signaling activates SMADs R-HSA-2173789
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Metabolism of proteins R-HSA-392499
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Signal Transduction R-HSA-162582
Deubiquitination R-HSA-5688426
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Ub-specific processing proteases R-HSA-5689880
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signaling by TGFB family members R-HSA-9006936
Signaling by TGF-beta Receptor Complex R-HSA-170834
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Metabolism of proteins R-HSA-392499
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
UCH proteinases R-HSA-5689603
Post-translational protein modification R-HSA-597592
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Disease R-HSA-1643685
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Metabolism of proteins R-HSA-392499
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Signaling by TGF-beta Receptor Complex R-HSA-170834
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Ub-specific processing proteases R-HSA-5689880
Signaling by TGFB family members R-HSA-9006936
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Post-translational protein modification R-HSA-597592
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Deubiquitination R-HSA-5688426
UCH proteinases R-HSA-5689603
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Disease R-HSA-1643685
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Deubiquitination R-HSA-5688426
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
UCH proteinases R-HSA-5689603
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Signal Transduction R-HSA-162582
Ub-specific processing proteases R-HSA-5689880
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Metabolism of proteins R-HSA-392499
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Post-translational protein modification R-HSA-597592
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Deubiquitination R-HSA-5688426
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR1 KD Mutants in Cancer R-HSA-3656532
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Metabolism of proteins R-HSA-392499
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
UCH proteinases R-HSA-5689603
Signaling by TGFB family members R-HSA-9006936
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Ub-specific processing proteases R-HSA-5689880
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Post-translational protein modification R-HSA-597592
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790
Signal Transduction R-HSA-162582
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
TGF-beta receptor signaling activates SMADs R-HSA-2173789
Loss of Function of TGFBR2 in Cancer R-HSA-3642278
Metabolism of proteins R-HSA-392499
TGFBR1 LBD Mutants in Cancer R-HSA-3656535
Signaling by TGFB family members R-HSA-9006936
Disease R-HSA-1643685
TGFBR1 KD Mutants in Cancer R-HSA-3656532
Deubiquitination R-HSA-5688426
Loss of Function of SMAD2/3 in Cancer R-HSA-3304349
Loss of Function of TGFBR1 in Cancer R-HSA-3656534
Post-translational protein modification R-HSA-597592
Signal Transduction R-HSA-162582
SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3304356
Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304351
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
UCH proteinases R-HSA-5689603
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-2173791
Ub-specific processing proteases R-HSA-5689880
Downregulation of TGF-beta receptor signaling R-HSA-2173788
Signaling by TGF-beta Receptor Complex R-HSA-170834
TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3645790

Expression Atlas ENSG00000106799
NCBI gene (formerly Entrezgene) 7046
GeneCards 11772
HGNC Symbol HGNC:11772
MIM gene 190181
MIM morbid 609192
UniProtKB Gene Name Q5T7S2
WikiGene 7046
Gene: MAP3K5
Ensembl ID : ENSG00000197442
Description: mitogen-activated protein kinase kinase kinase 5
Gene Synonyms: ASK1,MAPKKK5,MEKK5
1 APIs:
209 Possible Orthologues:

Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular responses to stress R-HSA-2262752
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Cellular responses to stimuli R-HSA-8953897
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752

Expression Atlas ENSG00000197442
NCBI gene (formerly Entrezgene) 4217
GeneCards 6857
HGNC Symbol HGNC:6857
MIM gene 602448
UniProtKB Gene Name Q99683
WikiGene 4217
Gene: IGF1R
Ensembl ID : ENSG00000140443
Description: insulin like growth factor 1 receptor
Gene Synonyms: CD221,IGFIR,IGFR,JTK13,MGC18216
20 APIs:
276 Possible Orthologues:

ESR-mediated signaling R-HSA-8939211
Signaling by Nuclear Receptors R-HSA-9006931
IGF1R signaling cascade R-HSA-2428924
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IRS-related events triggered by IGF1R R-HSA-2428928
Signal Transduction R-HSA-162582
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Extra-nuclear estrogen signaling R-HSA-9009391
SHC-related events triggered by IGF1R R-HSA-2428933
Signal Transduction R-HSA-162582
ESR-mediated signaling R-HSA-8939211
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SHC-related events triggered by IGF1R R-HSA-2428933
Extra-nuclear estrogen signaling R-HSA-9009391
IGF1R signaling cascade R-HSA-2428924
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
IGF1R signaling cascade R-HSA-2428924
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ESR-mediated signaling R-HSA-8939211
Extra-nuclear estrogen signaling R-HSA-9009391
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Nuclear Receptors R-HSA-9006931
ESR-mediated signaling R-HSA-8939211
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
IGF1R signaling cascade R-HSA-2428924
Signal Transduction R-HSA-162582
IRS-related events triggered by IGF1R R-HSA-2428928
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Nuclear Receptors R-HSA-9006931
IRS-related events triggered by IGF1R R-HSA-2428928
ESR-mediated signaling R-HSA-8939211
IGF1R signaling cascade R-HSA-2428924
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Extra-nuclear estrogen signaling R-HSA-9009391
IGF1R signaling cascade R-HSA-2428924
Extra-nuclear estrogen signaling R-HSA-9009391
ESR-mediated signaling R-HSA-8939211
Signaling by Nuclear Receptors R-HSA-9006931
SHC-related events triggered by IGF1R R-HSA-2428933
Signal Transduction R-HSA-162582
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
ESR-mediated signaling R-HSA-8939211
Extra-nuclear estrogen signaling R-HSA-9009391
Signal Transduction R-HSA-162582
IGF1R signaling cascade R-HSA-2428924
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Nuclear Receptors R-HSA-9006931
IRS-related events triggered by IGF1R R-HSA-2428928
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IRS-related events triggered by IGF1R R-HSA-2428928
SHC-related events triggered by IGF1R R-HSA-2428933
IGF1R signaling cascade R-HSA-2428924
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ESR-mediated signaling R-HSA-8939211
Extra-nuclear estrogen signaling R-HSA-9009391
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Signaling by Nuclear Receptors R-HSA-9006931
IGF1R signaling cascade R-HSA-2428924
SHC-related events triggered by IGF1R R-HSA-2428933
ESR-mediated signaling R-HSA-8939211
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Extra-nuclear estrogen signaling R-HSA-9009391
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Nuclear Receptors R-HSA-9006931
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
ESR-mediated signaling R-HSA-8939211
Extra-nuclear estrogen signaling R-HSA-9009391
Signal Transduction R-HSA-162582
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
IGF1R signaling cascade R-HSA-2428924
IRS-related events triggered by IGF1R R-HSA-2428928

Expression Atlas ENSG00000140443
LRG display in Ensembl gene LRG_1055
NCBI gene (formerly Entrezgene) 3480
GeneCards 5465
HGNC Symbol HGNC:5465
MIM gene 147370
MIM morbid 270450
UniProtKB Gene Name P08069
WikiGene 3480
Gene: ACVRL1
Ensembl ID : ENSG00000139567
Description: activin A receptor like type 1
Gene Synonyms: ACVRLK1,ALK1,HHT,HHT2,ORW2
2 APIs:
358 Possible Orthologues:

Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582

Expression Atlas ENSG00000139567
LRG display in Ensembl gene LRG_543
NCBI gene (formerly Entrezgene) 94
GeneCards 175
HGNC Symbol HGNC:175
MIM gene 601284
MIM morbid 600376
UniProtKB Gene Name P37023
WikiGene 94
Gene: PTK2B
Ensembl ID : ENSG00000120899
Description: protein tyrosine kinase 2 beta
Gene Synonyms: CADTK,CAKB,FAK2,PTK,PYK2,RAFTK
2 APIs:
213 Possible Orthologues:

RHO GTPase cycle R-HSA-9012999
Signaling by Interleukins R-HSA-449147
Signal regulatory protein family interactions R-HSA-391160
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGFA-VEGFR2 Pathway R-HSA-4420097
RHO GTPase cycle R-HSA-9012999
Signaling by VEGF R-HSA-194138
RHOU GTPase cycle R-HSA-9013420
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Rho GTPases R-HSA-194315
Interleukin-2 family signaling R-HSA-451927
Immune System R-HSA-168256
Cell-Cell communication R-HSA-1500931
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Interleukin-2 signaling R-HSA-9020558
Cell-Cell communication R-HSA-1500931
Signal Transduction R-HSA-162582
Interleukin-2 family signaling R-HSA-451927
Signaling by VEGF R-HSA-194138
Immune System R-HSA-168256
Signaling by Rho GTPases R-HSA-194315
Signal regulatory protein family interactions R-HSA-391160
RHOU GTPase cycle R-HSA-9013420
RHO GTPase cycle R-HSA-9012999
Signaling by Interleukins R-HSA-449147
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Interleukin-2 signaling R-HSA-9020558
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-2 signaling R-HSA-9020558
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases R-HSA-194315
Immune System R-HSA-168256
Cell-Cell communication R-HSA-1500931
VEGFA-VEGFR2 Pathway R-HSA-4420097
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Signal regulatory protein family interactions R-HSA-391160
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Interleukin-2 family signaling R-HSA-451927
Signaling by VEGF R-HSA-194138
Signaling by Interleukins R-HSA-449147
Signal Transduction R-HSA-162582
Signaling by Rho GTPases R-HSA-194315
Interleukin-2 family signaling R-HSA-451927
Interleukin-2 signaling R-HSA-9020558
Cytokine Signaling in Immune system R-HSA-1280215
Cell-Cell communication R-HSA-1500931
RHO GTPase cycle R-HSA-9012999
Signaling by Interleukins R-HSA-449147
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal regulatory protein family interactions R-HSA-391160
Signaling by VEGF R-HSA-194138
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Immune System R-HSA-168256
RHOU GTPase cycle R-HSA-9013420
VEGFA-VEGFR2 Pathway R-HSA-4420097
RHO GTPase cycle R-HSA-9012999
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Interleukins R-HSA-449147
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Signal regulatory protein family interactions R-HSA-391160
Interleukin-2 signaling R-HSA-9020558
Interleukin-2 family signaling R-HSA-451927
Signaling by Rho GTPases R-HSA-194315
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cell-Cell communication R-HSA-1500931
Immune System R-HSA-168256
RHOU GTPase cycle R-HSA-9013420
Signaling by VEGF R-HSA-194138
RHOU GTPase cycle R-HSA-9013420
RHO GTPase cycle R-HSA-9012999
Signal Transduction R-HSA-162582
Cell-Cell communication R-HSA-1500931
Signaling by Rho GTPases R-HSA-194315
Signaling by Interleukins R-HSA-449147
Cytokine Signaling in Immune system R-HSA-1280215
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal regulatory protein family interactions R-HSA-391160
Interleukin-2 family signaling R-HSA-451927
Immune System R-HSA-168256
Signaling by VEGF R-HSA-194138
Interleukin-2 signaling R-HSA-9020558
Cell-Cell communication R-HSA-1500931
Signaling by Interleukins R-HSA-449147
Interleukin-2 family signaling R-HSA-451927
RHO GTPase cycle R-HSA-9012999
Interleukin-2 signaling R-HSA-9020558
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by VEGF R-HSA-194138
Signal regulatory protein family interactions R-HSA-391160
RHOU GTPase cycle R-HSA-9013420
Signal Transduction R-HSA-162582
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Immune System R-HSA-168256
Signaling by Rho GTPases R-HSA-194315
Signal regulatory protein family interactions R-HSA-391160
VEGFA-VEGFR2 Pathway R-HSA-4420097
Immune System R-HSA-168256
Signaling by VEGF R-HSA-194138
Cytokine Signaling in Immune system R-HSA-1280215
Cell-Cell communication R-HSA-1500931
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Interleukins R-HSA-449147
Signal Transduction R-HSA-162582
Interleukin-2 family signaling R-HSA-451927
RHO GTPase cycle R-HSA-9012999
Interleukin-2 signaling R-HSA-9020558
Signaling by Rho GTPases R-HSA-194315
Cell-Cell communication R-HSA-1500931
Immune System R-HSA-168256
Cytokine Signaling in Immune system R-HSA-1280215
Signal regulatory protein family interactions R-HSA-391160
Signaling by Interleukins R-HSA-449147
Signaling by VEGF R-HSA-194138
RHO GTPase cycle R-HSA-9012999
Interleukin-2 signaling R-HSA-9020558
Interleukin-2 family signaling R-HSA-451927
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOU GTPase cycle R-HSA-9013420
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Rho GTPases R-HSA-194315
VEGFA-VEGFR2 Pathway R-HSA-4420097
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases R-HSA-194315
Signal regulatory protein family interactions R-HSA-391160
RHO GTPase cycle R-HSA-9012999
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signal Transduction R-HSA-162582
Interleukin-2 family signaling R-HSA-451927
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Cell-Cell communication R-HSA-1500931
Signaling by VEGF R-HSA-194138
Interleukin-2 signaling R-HSA-9020558

Expression Atlas ENSG00000120899
NCBI gene (formerly Entrezgene) 2185
GeneCards 9612
HGNC Symbol HGNC:9612
MIM gene 601212
UniProtKB Gene Name Q14289
WikiGene 2185