Gene: TOP2A
Ensembl ID : ENSG00000131747
Description: DNA topoisomerase II alpha
Gene Synonyms: TOP2,TOP2ALPHA,TOPIIA
21 APIs:
206 Possible Orthologues:

Mitotic G1 phase and G1/S transition R-HSA-453279
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
SUMOylation R-HSA-2990846
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
SUMOylation of DNA replication proteins R-HSA-4615885
SUMOylation of DNA replication proteins R-HSA-4615885
Cell Cycle R-HSA-1640170
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
SUMOylation R-HSA-2990846
Mitotic G1 phase and G1/S transition R-HSA-453279
G0 and Early G1 R-HSA-1538133
Cell Cycle, Mitotic R-HSA-69278
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Metabolism of proteins R-HSA-392499
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SUMOylation of DNA replication proteins R-HSA-4615885
SUMOylation R-HSA-2990846
Mitotic G1 phase and G1/S transition R-HSA-453279
Metabolism of proteins R-HSA-392499
Cell Cycle, Mitotic R-HSA-69278
G0 and Early G1 R-HSA-1538133
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle R-HSA-1640170
SUMOylation R-HSA-2990846
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
SUMOylation of DNA replication proteins R-HSA-4615885
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Mitotic G1 phase and G1/S transition R-HSA-453279
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
Cell Cycle, Mitotic R-HSA-69278
Post-translational protein modification R-HSA-597592
Mitotic G1 phase and G1/S transition R-HSA-453279
SUMOylation R-HSA-2990846
SUMOylation of DNA replication proteins R-HSA-4615885
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle R-HSA-1640170
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Mitotic G1 phase and G1/S transition R-HSA-453279
Metabolism of proteins R-HSA-392499
Post-translational protein modification R-HSA-597592
SUMOylation of DNA replication proteins R-HSA-4615885
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
G0 and Early G1 R-HSA-1538133
SUMOylation R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SUMOylation R-HSA-2990846
Cell Cycle R-HSA-1640170
G0 and Early G1 R-HSA-1538133
Cell Cycle, Mitotic R-HSA-69278
SUMOylation of DNA replication proteins R-HSA-4615885
Mitotic G1 phase and G1/S transition R-HSA-453279
Metabolism of proteins R-HSA-392499
Metabolism of proteins R-HSA-392499
SUMOylation of DNA replication proteins R-HSA-4615885
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle, Mitotic R-HSA-69278
SUMOylation R-HSA-2990846
G0 and Early G1 R-HSA-1538133
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle R-HSA-1640170
SUMOylation of DNA replication proteins R-HSA-4615885
SUMOylation R-HSA-2990846
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
G0 and Early G1 R-HSA-1538133
Metabolism of proteins R-HSA-392499
Mitotic G1 phase and G1/S transition R-HSA-453279
Post-translational protein modification R-HSA-597592
SUMOylation of DNA replication proteins R-HSA-4615885
Cell Cycle R-HSA-1640170
Metabolism of proteins R-HSA-392499
Mitotic G1 phase and G1/S transition R-HSA-453279
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle, Mitotic R-HSA-69278
Transcription of E2F targets under negative control by DREAM complex R-HSA-1362277
G0 and Early G1 R-HSA-1538133
Post-translational protein modification R-HSA-597592
SUMOylation R-HSA-2990846

Expression Atlas ENSG00000131747
NCBI gene (formerly Entrezgene) 7153
GeneCards 11989
HGNC Symbol HGNC:11989
MIM gene 126430
UniProtKB Gene Name P11388
WikiGene 7153
Gene: PPIA
Ensembl ID : ENSG00000196262
Description: peptidylprolyl isomerase A
Gene Synonyms: CYPA
3 APIs:
286 Possible Orthologues:

Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Neutrophil degranulation R-HSA-6798695
Uncoating of the HIV Virion R-HSA-162585
Adaptive Immune System R-HSA-1280218
Calcineurin activates NFAT R-HSA-2025928
Infectious disease R-HSA-5663205
Immune System R-HSA-168256
Host Interactions of HIV factors R-HSA-162909
Early Phase of HIV Life Cycle R-HSA-162594
Hemostasis R-HSA-109582
SARS-CoV-1 Infection R-HSA-9678108
Interleukin-12 signaling R-HSA-9020591
Integration of provirus R-HSA-162592
Assembly Of The HIV Virion R-HSA-175474
Budding and maturation of HIV virion R-HSA-162588
Reverse Transcription of HIV RNA R-HSA-162589
SARS-CoV Infections R-HSA-9679506
Basigin interactions R-HSA-210991
HIV Infection R-HSA-162906
Plus-strand DNA synthesis R-HSA-164525
Interleukin-12 family signaling R-HSA-447115
Binding and entry of HIV virion R-HSA-173107
Minus-strand DNA synthesis R-HSA-164516
Innate Immune System R-HSA-168249
SARS-CoV-1-host interactions R-HSA-9692914
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505
Platelet activation, signaling and aggregation R-HSA-76002
HIV Life Cycle R-HSA-162587
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689
Platelet degranulation R-HSA-114608
Late Phase of HIV Life Cycle R-HSA-162599
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916
Signaling by Interleukins R-HSA-449147
Disease R-HSA-1643685
Cell surface interactions at the vascular wall R-HSA-202733
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Late Phase of HIV Life Cycle R-HSA-162599
Platelet degranulation R-HSA-114608
Binding and entry of HIV virion R-HSA-173107
Adaptive Immune System R-HSA-1280218
Interleukin-12 signaling R-HSA-9020591
Budding and maturation of HIV virion R-HSA-162588
Reverse Transcription of HIV RNA R-HSA-162589
Early Phase of HIV Life Cycle R-HSA-162594
Interleukin-12 family signaling R-HSA-447115
Calcineurin activates NFAT R-HSA-2025928
Integration of provirus R-HSA-162592
Disease R-HSA-1643685
HIV Life Cycle R-HSA-162587
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916
SARS-CoV-1 Infection R-HSA-9678108
SARS-CoV Infections R-HSA-9679506
HIV Infection R-HSA-162906
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Immune System R-HSA-168256
Neutrophil degranulation R-HSA-6798695
Signaling by Interleukins R-HSA-449147
Cytokine Signaling in Immune system R-HSA-1280215
Basigin interactions R-HSA-210991
Cell surface interactions at the vascular wall R-HSA-202733
Hemostasis R-HSA-109582
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505
Innate Immune System R-HSA-168249
Host Interactions of HIV factors R-HSA-162909
Plus-strand DNA synthesis R-HSA-164525
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Minus-strand DNA synthesis R-HSA-164516
Infectious disease R-HSA-5663205
SARS-CoV-1-host interactions R-HSA-9692914
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Platelet activation, signaling and aggregation R-HSA-76002
Uncoating of the HIV Virion R-HSA-162585
Assembly Of The HIV Virion R-HSA-175474
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689
Reverse Transcription of HIV RNA R-HSA-162589
Cell surface interactions at the vascular wall R-HSA-202733
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916
Innate Immune System R-HSA-168249
Interleukin-12 signaling R-HSA-9020591
Adaptive Immune System R-HSA-1280218
Neutrophil degranulation R-HSA-6798695
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505
Early Phase of HIV Life Cycle R-HSA-162594
SARS-CoV-1 Infection R-HSA-9678108
Basigin interactions R-HSA-210991
Interleukin-12 family signaling R-HSA-447115
HIV Infection R-HSA-162906
Signaling by Interleukins R-HSA-449147
Uncoating of the HIV Virion R-HSA-162585
Plus-strand DNA synthesis R-HSA-164525
Host Interactions of HIV factors R-HSA-162909
Immune System R-HSA-168256
Signaling by the B Cell Receptor (BCR) R-HSA-983705
SARS-CoV-1-host interactions R-HSA-9692914
Minus-strand DNA synthesis R-HSA-164516
Budding and maturation of HIV virion R-HSA-162588
HIV Life Cycle R-HSA-162587
Platelet degranulation R-HSA-114608
Infectious disease R-HSA-5663205
Platelet activation, signaling and aggregation R-HSA-76002
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689
Late Phase of HIV Life Cycle R-HSA-162599
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Calcineurin activates NFAT R-HSA-2025928
Hemostasis R-HSA-109582
Disease R-HSA-1643685
Integration of provirus R-HSA-162592
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Assembly Of The HIV Virion R-HSA-175474
Binding and entry of HIV virion R-HSA-173107
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV Infections R-HSA-9679506
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505
Late Phase of HIV Life Cycle R-HSA-162599
Integration of provirus R-HSA-162592
Platelet activation, signaling and aggregation R-HSA-76002
Plus-strand DNA synthesis R-HSA-164525
Host Interactions of HIV factors R-HSA-162909
Platelet degranulation R-HSA-114608
Budding and maturation of HIV virion R-HSA-162588
Adaptive Immune System R-HSA-1280218
Innate Immune System R-HSA-168249
HIV Infection R-HSA-162906
Basigin interactions R-HSA-210991
Infectious disease R-HSA-5663205
Interleukin-12 signaling R-HSA-9020591
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916
Binding and entry of HIV virion R-HSA-173107
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Signaling by Interleukins R-HSA-449147
Early Phase of HIV Life Cycle R-HSA-162594
Immune System R-HSA-168256
Calcineurin activates NFAT R-HSA-2025928
Neutrophil degranulation R-HSA-6798695
SARS-CoV-1 Infection R-HSA-9678108
Hemostasis R-HSA-109582
Uncoating of the HIV Virion R-HSA-162585
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
SARS-CoV-1-host interactions R-HSA-9692914
Minus-strand DNA synthesis R-HSA-164516
HIV Life Cycle R-HSA-162587
Cell surface interactions at the vascular wall R-HSA-202733
Reverse Transcription of HIV RNA R-HSA-162589
Assembly Of The HIV Virion R-HSA-175474
Disease R-HSA-1643685
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689
Cytokine Signaling in Immune system R-HSA-1280215
SARS-CoV Infections R-HSA-9679506
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Interleukin-12 family signaling R-HSA-447115
HIV Life Cycle R-HSA-162587
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Binding and entry of HIV virion R-HSA-173107
SARS-CoV-1-host interactions R-HSA-9692914
Calcineurin activates NFAT R-HSA-2025928
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Interleukin-12 signaling R-HSA-9020591
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Platelet degranulation R-HSA-114608
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-12 family signaling R-HSA-447115
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505
Integration of provirus R-HSA-162592
Plus-strand DNA synthesis R-HSA-164525
Neutrophil degranulation R-HSA-6798695
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916
Disease R-HSA-1643685
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Basigin interactions R-HSA-210991
Uncoating of the HIV Virion R-HSA-162585
Early Phase of HIV Life Cycle R-HSA-162594
Reverse Transcription of HIV RNA R-HSA-162589
Budding and maturation of HIV virion R-HSA-162588
Hemostasis R-HSA-109582
Infectious disease R-HSA-5663205
Late Phase of HIV Life Cycle R-HSA-162599
Innate Immune System R-HSA-168249
Assembly Of The HIV Virion R-HSA-175474
HIV Infection R-HSA-162906
SARS-CoV Infections R-HSA-9679506
Minus-strand DNA synthesis R-HSA-164516
SARS-CoV-1 Infection R-HSA-9678108
Host Interactions of HIV factors R-HSA-162909
Platelet activation, signaling and aggregation R-HSA-76002
Adaptive Immune System R-HSA-1280218
Cell surface interactions at the vascular wall R-HSA-202733
Cytokine Signaling in Immune system R-HSA-1280215
Early Phase of HIV Life Cycle R-HSA-162594
Disease R-HSA-1643685
SARS-CoV-1 Infection R-HSA-9678108
Budding and maturation of HIV virion R-HSA-162588
Plus-strand DNA synthesis R-HSA-164525
APOBEC3G mediated resistance to HIV-1 infection R-HSA-180689
Immune System R-HSA-168256
Integration of provirus R-HSA-162592
Minus-strand DNA synthesis R-HSA-164516
Platelet activation, signaling and aggregation R-HSA-76002
SARS-CoV Infections R-HSA-9679506
Neutrophil degranulation R-HSA-6798695
HIV Infection R-HSA-162906
Reverse Transcription of HIV RNA R-HSA-162589
Calcineurin activates NFAT R-HSA-2025928
Innate Immune System R-HSA-168249
Basigin interactions R-HSA-210991
Adaptive Immune System R-HSA-1280218
Hemostasis R-HSA-109582
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
HIV Life Cycle R-HSA-162587
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Uncoating of the HIV Virion R-HSA-162585
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Platelet degranulation R-HSA-114608
Interleukin-12 signaling R-HSA-9020591
SARS-CoV-1 activates/modulates innate immune responses R-HSA-9692916
Assembly Of The HIV Virion R-HSA-175474
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-8950505
Interleukin-12 family signaling R-HSA-447115
Signaling by Interleukins R-HSA-449147
Host Interactions of HIV factors R-HSA-162909
Infectious disease R-HSA-5663205
Binding and entry of HIV virion R-HSA-173107
Late Phase of HIV Life Cycle R-HSA-162599
SARS-CoV-1-host interactions R-HSA-9692914

Expression Atlas ENSG00000196262
NCBI gene (formerly Entrezgene) 5478
GeneCards 9253
HGNC Symbol HGNC:9253
MIM gene 123840
UniProtKB Gene Name V9HWF5
WikiGene 5478
Gene: CCDC6
Ensembl ID : ENSG00000108091
Description: coiled-coil domain containing 6
Gene Synonyms: D10S170,H4,PTC,PTC1,TPC,TST1
2 APIs:
223 Possible Orthologues:

Expression Atlas ENSG00000108091
NCBI gene (formerly Entrezgene) 8030
GeneCards 18782
HGNC Symbol HGNC:18782
MIM gene 601985
UniProtKB Gene Name Q16204
WikiGene 8030
Gene: MAP2K1
Ensembl ID : ENSG00000169032
Description: mitogen-activated protein kinase kinase 1
Gene Synonyms: MAPKK1,MEK1,PRKMK1
20 APIs:
203 Possible Orthologues:

Oncogenic MAPK signaling R-HSA-6802957
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Disease R-HSA-1643685
Signalling to ERKs R-HSA-187687
Axon guidance R-HSA-422475
MAP2K and MAPK activation R-HSA-5674135
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
L1CAM interactions R-HSA-373760
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll-like Receptor Cascades R-HSA-168898
Signaling downstream of RAS mutants R-HSA-9649948
Innate Immune System R-HSA-168249
RAF activation R-HSA-5673000
Signaling by NTRKs R-HSA-166520
MAPK3 (ERK1) activation R-HSA-110056
Uptake and function of anthrax toxins R-HSA-5210891
MyD88 cascade initiated on plasma membrane R-HSA-975871
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Nervous system development R-HSA-9675108
Prolonged ERK activation events R-HSA-169893
MAPK family signaling cascades R-HSA-5683057
Immune System R-HSA-168256
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative feedback regulation of MAPK pathway R-HSA-5674499
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Developmental Biology R-HSA-1266738
RAF-independent MAPK1/3 activation R-HSA-112409
Signal transduction by L1 R-HSA-445144
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Negative regulation of MAPK pathway R-HSA-5675221
Signal Transduction R-HSA-162582
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Infectious disease R-HSA-5663205
Cytokine Signaling in Immune system R-HSA-1280215
MyD88-independent TLR4 cascade R-HSA-166166
RAF/MAP kinase cascade R-HSA-5673001
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Uptake and actions of bacterial toxins R-HSA-5339562
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Frs2-mediated activation R-HSA-170968
Signaling by MAP2K mutants R-HSA-9652169
Interleukin-1 signaling R-HSA-9020702
Signaling by RAF1 mutants R-HSA-9656223
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Oncogenic MAPK signaling R-HSA-6802957
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
MAP kinase activation R-HSA-450294
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by RAS mutants R-HSA-6802949
MyD88 dependent cascade initiated on endosome R-HSA-975155
Uptake and function of anthrax toxins R-HSA-5210891
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Infectious disease R-HSA-5663205
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of MAPK pathway R-HSA-5675221
Axon guidance R-HSA-422475
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MyD88 cascade initiated on plasma membrane R-HSA-975871
L1CAM interactions R-HSA-373760
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signal transduction by L1 R-HSA-445144
Signalling to ERKs R-HSA-187687
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by RAF1 mutants R-HSA-9656223
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MAPK family signaling cascades R-HSA-5683057
MAPK3 (ERK1) activation R-HSA-110056
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signal Transduction R-HSA-162582
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Interleukin-1 family signaling R-HSA-446652
Interleukin-17 signaling R-HSA-448424
Cytokine Signaling in Immune system R-HSA-1280215
MyD88-independent TLR4 cascade R-HSA-166166
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Frs2-mediated activation R-HSA-170968
Negative feedback regulation of MAPK pathway R-HSA-5674499
Developmental Biology R-HSA-1266738
Interleukin-1 signaling R-HSA-9020702
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Nervous system development R-HSA-9675108
Prolonged ERK activation events R-HSA-169893
RAF activation R-HSA-5673000
Immune System R-HSA-168256
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Toll-like Receptor Cascades R-HSA-168898
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
RAF-independent MAPK1/3 activation R-HSA-112409
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling downstream of RAS mutants R-HSA-9649948
Innate Immune System R-HSA-168249
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by MAP2K mutants R-HSA-9652169
MAP kinase activation R-HSA-450294
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Immune System R-HSA-168256
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Prolonged ERK activation events R-HSA-169893
Signal transduction by L1 R-HSA-445144
Infectious disease R-HSA-5663205
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Interleukins R-HSA-449147
RAF/MAP kinase cascade R-HSA-5673001
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Axon guidance R-HSA-422475
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
Negative regulation of MAPK pathway R-HSA-5675221
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
L1CAM interactions R-HSA-373760
Nervous system development R-HSA-9675108
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAPK3 (ERK1) activation R-HSA-110056
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MAPK family signaling cascades R-HSA-5683057
Signal Transduction R-HSA-162582
Uptake and actions of bacterial toxins R-HSA-5339562
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
Disease R-HSA-1643685
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Cytokine Signaling in Immune system R-HSA-1280215
RAF-independent MAPK1/3 activation R-HSA-112409
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAP kinase activation R-HSA-450294
Toll-like Receptor Cascades R-HSA-168898
MAPK1/MAPK3 signaling R-HSA-5684996
Interleukin-17 signaling R-HSA-448424
Frs2-mediated activation R-HSA-170968
Developmental Biology R-HSA-1266738
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling downstream of RAS mutants R-HSA-9649948
Innate Immune System R-HSA-168249
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Interleukin-1 family signaling R-HSA-446652
MAP2K and MAPK activation R-HSA-5674135
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by MAP2K mutants R-HSA-9652169
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
Developmental Biology R-HSA-1266738
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
RAF-independent MAPK1/3 activation R-HSA-112409
Signal transduction by L1 R-HSA-445144
Infectious disease R-HSA-5663205
Signaling by Interleukins R-HSA-449147
Signaling by NTRKs R-HSA-166520
Signal Transduction R-HSA-162582
RAF/MAP kinase cascade R-HSA-5673001
L1CAM interactions R-HSA-373760
RAF activation R-HSA-5673000
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by NTRK1 (TRKA) R-HSA-187037
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Cytokine Signaling in Immune system R-HSA-1280215
Signaling downstream of RAS mutants R-HSA-9649948
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signalling to ERKs R-HSA-187687
MAP kinase activation R-HSA-450294
Interleukin-1 family signaling R-HSA-446652
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK family signaling cascades R-HSA-5683057
Immune System R-HSA-168256
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
Interleukin-17 signaling R-HSA-448424
Negative regulation of MAPK pathway R-HSA-5675221
MyD88 dependent cascade initiated on endosome R-HSA-975155
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by RAS mutants R-HSA-6802949
Nervous system development R-HSA-9675108
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Innate Immune System R-HSA-168249
Signaling by MAP2K mutants R-HSA-9652169
MAPK3 (ERK1) activation R-HSA-110056
Prolonged ERK activation events R-HSA-169893
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by RAF1 mutants R-HSA-9656223
Uptake and actions of bacterial toxins R-HSA-5339562
MAP2K and MAPK activation R-HSA-5674135
Interleukin-1 signaling R-HSA-9020702
Axon guidance R-HSA-422475
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Cytokine Signaling in Immune system R-HSA-1280215
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Interleukin-17 signaling R-HSA-448424
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
MAP kinase activation R-HSA-450294
Immune System R-HSA-168256
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MAPK3 (ERK1) activation R-HSA-110056
Uptake and function of anthrax toxins R-HSA-5210891
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRK1 (TRKA) R-HSA-187037
Axon guidance R-HSA-422475
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Nervous system development R-HSA-9675108
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK1/MAPK3 signaling R-HSA-5684996
Prolonged ERK activation events R-HSA-169893
L1CAM interactions R-HSA-373760
Oncogenic MAPK signaling R-HSA-6802957
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAPK family signaling cascades R-HSA-5683057
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by RAS mutants R-HSA-6802949
RAF-independent MAPK1/3 activation R-HSA-112409
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
MyD88 dependent cascade initiated on endosome R-HSA-975155
Developmental Biology R-HSA-1266738
Frs2-mediated activation R-HSA-170968
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signalling to ERKs R-HSA-187687
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative feedback regulation of MAPK pathway R-HSA-5674499
Uptake and actions of bacterial toxins R-HSA-5339562
RAF activation R-HSA-5673000
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by RAF1 mutants R-HSA-9656223
Interleukin-1 signaling R-HSA-9020702
Toll-like Receptor Cascades R-HSA-168898
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Infectious disease R-HSA-5663205
Signal Transduction R-HSA-162582
MAP2K and MAPK activation R-HSA-5674135
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
RAF/MAP kinase cascade R-HSA-5673001
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by NTRKs R-HSA-166520
Signaling by MAP2K mutants R-HSA-9652169
Signal transduction by L1 R-HSA-445144
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Cytokine Signaling in Immune system R-HSA-1280215
Toll-like Receptor Cascades R-HSA-168898
MAPK3 (ERK1) activation R-HSA-110056
Axon guidance R-HSA-422475
Uptake and function of anthrax toxins R-HSA-5210891
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Interleukin-1 signaling R-HSA-9020702
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
MAPK1/MAPK3 signaling R-HSA-5684996
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
L1CAM interactions R-HSA-373760
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Nervous system development R-HSA-9675108
Prolonged ERK activation events R-HSA-169893
MyD88 cascade initiated on plasma membrane R-HSA-975871
Infectious disease R-HSA-5663205
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Developmental Biology R-HSA-1266738
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by RAF1 mutants R-HSA-9656223
Signaling by NTRKs R-HSA-166520
Signaling by RAS mutants R-HSA-6802949
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAPK family signaling cascades R-HSA-5683057
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
RAF-independent MAPK1/3 activation R-HSA-112409
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP2K and MAPK activation R-HSA-5674135
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Frs2-mediated activation R-HSA-170968
MAP kinase activation R-HSA-450294
Interleukin-1 family signaling R-HSA-446652
Oncogenic MAPK signaling R-HSA-6802957
Immune System R-HSA-168256
Signal transduction by L1 R-HSA-445144
RAF activation R-HSA-5673000
Disease R-HSA-1643685
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MAP2K mutants R-HSA-9652169
Innate Immune System R-HSA-168249
MyD88 dependent cascade initiated on endosome R-HSA-975155
Signaling by Interleukins R-HSA-449147
MyD88-independent TLR4 cascade R-HSA-166166
Negative regulation of MAPK pathway R-HSA-5675221
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MAPK family signaling cascades R-HSA-5683057
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRK1 (TRKA) R-HSA-187037
Signal transduction by L1 R-HSA-445144
L1CAM interactions R-HSA-373760
Signaling by NTRKs R-HSA-166520
Negative regulation of MAPK pathway R-HSA-5675221
Interleukin-17 signaling R-HSA-448424
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Nervous system development R-HSA-9675108
Signaling downstream of RAS mutants R-HSA-9649948
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MyD88 cascade initiated on plasma membrane R-HSA-975871
RAF-independent MAPK1/3 activation R-HSA-112409
Developmental Biology R-HSA-1266738
Innate Immune System R-HSA-168249
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAP2K and MAPK activation R-HSA-5674135
Uptake and function of anthrax toxins R-HSA-5210891
Prolonged ERK activation events R-HSA-169893
Signaling by RAS mutants R-HSA-6802949
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by Interleukins R-HSA-449147
Signalling to ERKs R-HSA-187687
Immune System R-HSA-168256
Signaling by RAF1 mutants R-HSA-9656223
Infectious disease R-HSA-5663205
MAPK1/MAPK3 signaling R-HSA-5684996
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by MAP2K mutants R-HSA-9652169
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MAPK3 (ERK1) activation R-HSA-110056
MAP kinase activation R-HSA-450294
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Frs2-mediated activation R-HSA-170968
Axon guidance R-HSA-422475
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Disease R-HSA-1643685
Uptake and actions of bacterial toxins R-HSA-5339562
RAF activation R-HSA-5673000
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MAP2K and MAPK activation R-HSA-5674135
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MAPK3 (ERK1) activation R-HSA-110056
Axon guidance R-HSA-422475
Nervous system development R-HSA-9675108
Negative regulation of MAPK pathway R-HSA-5675221
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signaling by RAF1 mutants R-HSA-9656223
Infectious disease R-HSA-5663205
Signaling by MAP2K mutants R-HSA-9652169
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
RAF-independent MAPK1/3 activation R-HSA-112409
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
MyD88 dependent cascade initiated on endosome R-HSA-975155
RAF activation R-HSA-5673000
Toll-like Receptor Cascades R-HSA-168898
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by RAS mutants R-HSA-6802949
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling downstream of RAS mutants R-HSA-9649948
Prolonged ERK activation events R-HSA-169893
Oncogenic MAPK signaling R-HSA-6802957
MAPK1/MAPK3 signaling R-HSA-5684996
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
MyD88 cascade initiated on plasma membrane R-HSA-975871
L1CAM interactions R-HSA-373760
Innate Immune System R-HSA-168249
MAP kinase activation R-HSA-450294
Signal transduction by L1 R-HSA-445144
Developmental Biology R-HSA-1266738
Interleukin-17 signaling R-HSA-448424
Negative feedback regulation of MAPK pathway R-HSA-5674499
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Uptake and actions of bacterial toxins R-HSA-5339562
Immune System R-HSA-168256
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF/MAP kinase cascade R-HSA-5673001
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRKs R-HSA-166520
Cytokine Signaling in Immune system R-HSA-1280215
Uptake and function of anthrax toxins R-HSA-5210891
Interleukin-1 family signaling R-HSA-446652
Signaling by NTRK1 (TRKA) R-HSA-187037
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Frs2-mediated activation R-HSA-170968
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Interleukins R-HSA-449147
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Immune System R-HSA-168256
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by Interleukins R-HSA-449147
Nervous system development R-HSA-9675108
MyD88 cascade initiated on plasma membrane R-HSA-975871
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
Negative feedback regulation of MAPK pathway R-HSA-5674499
Infectious disease R-HSA-5663205
Interleukin-1 family signaling R-HSA-446652
Signaling by NTRKs R-HSA-166520
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAPK3 (ERK1) activation R-HSA-110056
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Uptake and actions of bacterial toxins R-HSA-5339562
Frs2-mediated activation R-HSA-170968
Signaling by MAP2K mutants R-HSA-9652169
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Innate Immune System R-HSA-168249
Oncogenic MAPK signaling R-HSA-6802957
Interleukin-17 signaling R-HSA-448424
L1CAM interactions R-HSA-373760
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Negative regulation of MAPK pathway R-HSA-5675221
RAF activation R-HSA-5673000
Disease R-HSA-1643685
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP kinase activation R-HSA-450294
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by RAF1 mutants R-HSA-9656223
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MAPK family signaling cascades R-HSA-5683057
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Interleukin-1 signaling R-HSA-9020702
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Signal transduction by L1 R-HSA-445144
Cytokine Signaling in Immune system R-HSA-1280215
Signaling downstream of RAS mutants R-HSA-9649948
Axon guidance R-HSA-422475
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Prolonged ERK activation events R-HSA-169893
MAP2K and MAPK activation R-HSA-5674135
RAF-independent MAPK1/3 activation R-HSA-112409
Developmental Biology R-HSA-1266738
Uptake and function of anthrax toxins R-HSA-5210891
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MAPK3 (ERK1) activation R-HSA-110056
Axon guidance R-HSA-422475
MAP2K and MAPK activation R-HSA-5674135
Immune System R-HSA-168256
Interleukin-1 family signaling R-HSA-446652
Toll-like Receptor Cascades R-HSA-168898
L1CAM interactions R-HSA-373760
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Disease R-HSA-1643685
RAF activation R-HSA-5673000
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Signaling by NTRKs R-HSA-166520
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by NTRK1 (TRKA) R-HSA-187037
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Interleukin-1 signaling R-HSA-9020702
Nervous system development R-HSA-9675108
MAP kinase activation R-HSA-450294
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Developmental Biology R-HSA-1266738
RAF/MAP kinase cascade R-HSA-5673001
Signal Transduction R-HSA-162582
Signaling by MAP2K mutants R-HSA-9652169
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative feedback regulation of MAPK pathway R-HSA-5674499
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling downstream of RAS mutants R-HSA-9649948
MyD88-independent TLR4 cascade R-HSA-166166
Signal transduction by L1 R-HSA-445144
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Signaling by Interleukins R-HSA-449147
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Frs2-mediated activation R-HSA-170968
Prolonged ERK activation events R-HSA-169893
Interleukin-17 signaling R-HSA-448424
Signaling by RAF1 mutants R-HSA-9656223
Negative regulation of MAPK pathway R-HSA-5675221
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signalling to ERKs R-HSA-187687
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF-independent MAPK1/3 activation R-HSA-112409
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Uptake and actions of bacterial toxins R-HSA-5339562
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
Signaling by RAS mutants R-HSA-6802949
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by NTRKs R-HSA-166520
Axon guidance R-HSA-422475
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Interleukin-17 signaling R-HSA-448424
Negative feedback regulation of MAPK pathway R-HSA-5674499
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Negative regulation of MAPK pathway R-HSA-5675221
Oncogenic MAPK signaling R-HSA-6802957
Signal Transduction R-HSA-162582
Uptake and actions of bacterial toxins R-HSA-5339562
MAP kinase activation R-HSA-450294
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF activation R-HSA-5673000
MyD88 dependent cascade initiated on endosome R-HSA-975155
Interleukin-1 signaling R-HSA-9020702
Prolonged ERK activation events R-HSA-169893
MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-5684264
Immune System R-HSA-168256
MyD88-independent TLR4 cascade R-HSA-166166
RAF-independent MAPK1/3 activation R-HSA-112409
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Signaling by RAS mutants R-HSA-6802949
Infectious disease R-HSA-5663205
MAPK3 (ERK1) activation R-HSA-110056
Developmental Biology R-HSA-1266738
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Toll-like Receptor Cascades R-HSA-168898
MAP2K and MAPK activation R-HSA-5674135
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Cytokine Signaling in Immune system R-HSA-1280215
Innate Immune System R-HSA-168249
MAPK family signaling cascades R-HSA-5683057
MyD88 cascade initiated on plasma membrane R-HSA-975871
Signaling by MAP2K mutants R-HSA-9652169
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Nervous system development R-HSA-9675108
Interleukin-1 family signaling R-HSA-446652
Disease R-HSA-1643685
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by Interleukins R-HSA-449147
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Uptake and function of anthrax toxins R-HSA-5210891
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Signal transduction by L1 R-HSA-445144
Frs2-mediated activation R-HSA-170968
Signalling to ERKs R-HSA-187687
L1CAM interactions R-HSA-373760
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by RAF1 mutants R-HSA-9656223

Expression Atlas ENSG00000169032
LRG display in Ensembl gene LRG_725
NCBI gene (formerly Entrezgene) 5604
GeneCards 6840
HGNC Symbol HGNC:6840
MIM gene 176872
MIM morbid 615279
UniProtKB Gene Name Q02750
WikiGene 5604
Gene: CDK6
Ensembl ID : ENSG00000105810
Description: cyclin dependent kinase 6
Gene Synonyms: PLSTIRE
9 APIs:
201 Possible Orthologues:

Cell Cycle, Mitotic R-HSA-69278
Cellular Senescence R-HSA-2559583
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Transcriptional regulation by RUNX1 R-HSA-8878171
Diseases of mitotic cell cycle R-HSA-9675126
Cell Cycle R-HSA-1640170
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
Oncogene Induced Senescence R-HSA-2559585
RNA Polymerase II Transcription R-HSA-73857
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Diseases of Cellular Senescence R-HSA-9630747
Cellular responses to stress R-HSA-2262752
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Cyclin D associated events in G1 R-HSA-69231
Disease R-HSA-1643685
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Generic Transcription Pathway R-HSA-212436
Cellular responses to stimuli R-HSA-8953897
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
G1 Phase R-HSA-69236
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Diseases of cellular response to stress R-HSA-9675132
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Mitotic G1 phase and G1/S transition R-HSA-453279
Cellular responses to stress R-HSA-2262752
Disease R-HSA-1643685
Cell Cycle, Mitotic R-HSA-69278
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Cellular responses to stimuli R-HSA-8953897
Cyclin D associated events in G1 R-HSA-69231
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Gene expression (Transcription) R-HSA-74160
Diseases of Cellular Senescence R-HSA-9630747
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle R-HSA-1640170
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Diseases of mitotic cell cycle R-HSA-9675126
RNA Polymerase II Transcription R-HSA-73857
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Diseases of cellular response to stress R-HSA-9675132
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Transcriptional regulation by RUNX1 R-HSA-8878171
Oxidative Stress Induced Senescence R-HSA-2559580
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
G1 Phase R-HSA-69236
Generic Transcription Pathway R-HSA-212436
Cellular Senescence R-HSA-2559583
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Oncogene Induced Senescence R-HSA-2559585
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Oncogene Induced Senescence R-HSA-2559585
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cellular responses to stimuli R-HSA-8953897
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Mitotic G1 phase and G1/S transition R-HSA-453279
Oxidative Stress Induced Senescence R-HSA-2559580
G1 Phase R-HSA-69236
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Diseases of mitotic cell cycle R-HSA-9675126
Disease R-HSA-1643685
Cellular responses to stress R-HSA-2262752
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
RNA Polymerase II Transcription R-HSA-73857
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Transcriptional regulation by RUNX1 R-HSA-8878171
Cellular Senescence R-HSA-2559583
Diseases of Cellular Senescence R-HSA-9630747
Generic Transcription Pathway R-HSA-212436
Diseases of cellular response to stress R-HSA-9675132
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Gene expression (Transcription) R-HSA-74160
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cyclin D associated events in G1 R-HSA-69231
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
G1 Phase R-HSA-69236
Cyclin D associated events in G1 R-HSA-69231
Generic Transcription Pathway R-HSA-212436
Cell Cycle, Mitotic R-HSA-69278
RNA Polymerase II Transcription R-HSA-73857
Cellular Senescence R-HSA-2559583
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Transcriptional regulation by RUNX1 R-HSA-8878171
Cellular responses to stress R-HSA-2262752
Cell Cycle R-HSA-1640170
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Diseases of cellular response to stress R-HSA-9675132
Diseases of Cellular Senescence R-HSA-9630747
Oncogene Induced Senescence R-HSA-2559585
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cellular responses to stimuli R-HSA-8953897
Disease R-HSA-1643685
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Mitotic G1 phase and G1/S transition R-HSA-453279
Diseases of mitotic cell cycle R-HSA-9675126
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
RNA Polymerase II Transcription R-HSA-73857
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
G1 Phase R-HSA-69236
Generic Transcription Pathway R-HSA-212436
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Diseases of Cellular Senescence R-HSA-9630747
Cellular responses to stress R-HSA-2262752
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Cellular Senescence R-HSA-2559583
Oxidative Stress Induced Senescence R-HSA-2559580
Diseases of mitotic cell cycle R-HSA-9675126
Cyclin D associated events in G1 R-HSA-69231
Cellular responses to stimuli R-HSA-8953897
Diseases of cellular response to stress R-HSA-9675132
Cell Cycle R-HSA-1640170
Transcriptional regulation by RUNX1 R-HSA-8878171
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Disease R-HSA-1643685
Gene expression (Transcription) R-HSA-74160
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Oncogene Induced Senescence R-HSA-2559585
Cell Cycle, Mitotic R-HSA-69278
Mitotic G1 phase and G1/S transition R-HSA-453279
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
RNA Polymerase II Transcription R-HSA-73857
Oncogene Induced Senescence R-HSA-2559585
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Transcriptional regulation by RUNX1 R-HSA-8878171
Oxidative Stress Induced Senescence R-HSA-2559580
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Diseases of Cellular Senescence R-HSA-9630747
Gene expression (Transcription) R-HSA-74160
Cellular responses to stimuli R-HSA-8953897
Generic Transcription Pathway R-HSA-212436
Regulation of RUNX1 Expression and Activity R-HSA-8934593
G1 Phase R-HSA-69236
Cellular responses to stress R-HSA-2262752
Mitotic G1 phase and G1/S transition R-HSA-453279
Diseases of mitotic cell cycle R-HSA-9675126
Disease R-HSA-1643685
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Cellular Senescence R-HSA-2559583
Cell Cycle, Mitotic R-HSA-69278
Diseases of cellular response to stress R-HSA-9675132
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cyclin D associated events in G1 R-HSA-69231
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Cell Cycle R-HSA-1640170
Cyclin D associated events in G1 R-HSA-69231
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Disease R-HSA-1643685
Cell Cycle R-HSA-1640170
Oxidative Stress Induced Senescence R-HSA-2559580
G1 Phase R-HSA-69236
Diseases of cellular response to stress R-HSA-9675132
Oncogene Induced Senescence R-HSA-2559585
Transcriptional regulation by RUNX1 R-HSA-8878171
Generic Transcription Pathway R-HSA-212436
Cellular Senescence R-HSA-2559583
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
RNA Polymerase II Transcription R-HSA-73857
Gene expression (Transcription) R-HSA-74160
Cellular responses to stimuli R-HSA-8953897
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Cell Cycle, Mitotic R-HSA-69278
Cellular responses to stress R-HSA-2262752
Diseases of mitotic cell cycle R-HSA-9675126
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Diseases of Cellular Senescence R-HSA-9630747
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Mitotic G1 phase and G1/S transition R-HSA-453279
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Diseases of mitotic cell cycle R-HSA-9675126
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Generic Transcription Pathway R-HSA-212436
Cellular responses to stimuli R-HSA-8953897
Cell Cycle R-HSA-1640170
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Cellular responses to stress R-HSA-2262752
Mitotic G1 phase and G1/S transition R-HSA-453279
Gene expression (Transcription) R-HSA-74160
Cyclin D associated events in G1 R-HSA-69231
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
G1 Phase R-HSA-69236
Cellular Senescence R-HSA-2559583
Transcriptional regulation by RUNX1 R-HSA-8878171
Diseases of cellular response to stress R-HSA-9675132
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle, Mitotic R-HSA-69278
Oncogene Induced Senescence R-HSA-2559585
Oxidative Stress Induced Senescence R-HSA-2559580
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Disease R-HSA-1643685
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Diseases of Cellular Senescence R-HSA-9630747
Cellular responses to stress R-HSA-2262752
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Diseases of cellular response to stress R-HSA-9675132
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
G1 Phase R-HSA-69236
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
Cellular Senescence R-HSA-2559583
Cell Cycle, Mitotic R-HSA-69278
Mitotic G1 phase and G1/S transition R-HSA-453279
Oxidative Stress Induced Senescence R-HSA-2559580
Oncogene Induced Senescence R-HSA-2559585
Diseases of Cellular Senescence R-HSA-9630747
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Generic Transcription Pathway R-HSA-212436
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Cyclin D associated events in G1 R-HSA-69231
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Cell Cycle R-HSA-1640170
Transcriptional regulation by RUNX1 R-HSA-8878171
Disease R-HSA-1643685
Diseases of mitotic cell cycle R-HSA-9675126
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cellular responses to stimuli R-HSA-8953897
G1 Phase R-HSA-69236
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Cellular Senescence R-HSA-2559583
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Cyclin D associated events in G1 R-HSA-69231
Diseases of mitotic cell cycle R-HSA-9675126
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Oxidative Stress Induced Senescence R-HSA-2559580
Mitotic G1 phase and G1/S transition R-HSA-453279
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
RNA Polymerase II Transcription R-HSA-73857
Diseases of cellular response to stress R-HSA-9675132
Disease R-HSA-1643685
Regulation of RUNX1 Expression and Activity R-HSA-8934593
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Oncogene Induced Senescence R-HSA-2559585
Cell Cycle R-HSA-1640170
Cell Cycle, Mitotic R-HSA-69278
Diseases of Cellular Senescence R-HSA-9630747
Transcriptional regulation by RUNX1 R-HSA-8878171
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897

Expression Atlas ENSG00000105810
LRG display in Ensembl gene LRG_991
NCBI gene (formerly Entrezgene) 1021
GeneCards 1777
HGNC Symbol HGNC:1777
MIM gene 603368
MIM morbid 616080
UniProtKB Gene Name Q00534
WikiGene 1021
Gene: NTRK2
Ensembl ID : ENSG00000148053
Description: neurotrophic receptor tyrosine kinase 2
Gene Synonyms: TRKB
3 APIs:
288 Possible Orthologues:

NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NGF-independant TRKA activation R-HSA-187024
Activation of TRKA receptors R-HSA-187015
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
Activated NTRK2 signals through PLCG1 R-HSA-9026527
NTRK2 activates RAC1 R-HSA-9032759
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Signaling by NTRKs R-HSA-166520
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activated NTRK2 signals through FYN R-HSA-9032500
Signaling by NTRK1 (TRKA) R-HSA-187037
Signal Transduction R-HSA-162582
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Activated NTRK2 signals through RAS R-HSA-9026519
Activated NTRK2 signals through CDK5 R-HSA-9032845
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Activated NTRK2 signals through CDK5 R-HSA-9032845
NGF-independant TRKA activation R-HSA-187024
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by NTRKs R-HSA-166520
NTRK2 activates RAC1 R-HSA-9032759
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Activated NTRK2 signals through RAS R-HSA-9026519
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Signal Transduction R-HSA-162582
Activated NTRK2 signals through FYN R-HSA-9032500
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Activation of TRKA receptors R-HSA-187015
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by NTRK2 (TRKB) R-HSA-9006115
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
Activated NTRK2 signals through CDK5 R-HSA-9032845
Activated NTRK2 signals through RAS R-HSA-9026519
Activation of TRKA receptors R-HSA-187015
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Signaling by NTRKs R-HSA-166520
Activated NTRK2 signals through PI3K R-HSA-9028335
NGF-independant TRKA activation R-HSA-187024
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activated NTRK2 signals through FYN R-HSA-9032500
NTRK2 activates RAC1 R-HSA-9032759
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by NTRK1 (TRKA) R-HSA-187037
NGF-independant TRKA activation R-HSA-187024
Signaling by NTRK1 (TRKA) R-HSA-187037
NTRK2 activates RAC1 R-HSA-9032759
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Activated NTRK2 signals through CDK5 R-HSA-9032845
Activated NTRK2 signals through FYN R-HSA-9032500
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Signaling by NTRKs R-HSA-166520
Activated NTRK2 signals through RAS R-HSA-9026519
Activation of TRKA receptors R-HSA-187015
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
Signal Transduction R-HSA-162582
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signal Transduction R-HSA-162582
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Signaling by NTRK2 (TRKB) R-HSA-9006115
NTRK2 activates RAC1 R-HSA-9032759
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Activated NTRK2 signals through RAS R-HSA-9026519
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by NTRKs R-HSA-166520
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Activated NTRK2 signals through FYN R-HSA-9032500
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Activation of TRKA receptors R-HSA-187015
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
NGF-independant TRKA activation R-HSA-187024
Activated NTRK2 signals through CDK5 R-HSA-9032845
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Signaling by NTRKs R-HSA-166520
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Activated NTRK2 signals through CDK5 R-HSA-9032845
NTRK2 activates RAC1 R-HSA-9032759
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
Activated NTRK2 signals through RAS R-HSA-9026519
Activation of TRKA receptors R-HSA-187015
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activated NTRK2 signals through FYN R-HSA-9032500
NGF-independant TRKA activation R-HSA-187024
Signaling by NTRK1 (TRKA) R-HSA-187037
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by NTRK2 (TRKB) R-HSA-9006115
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Activated NTRK2 signals through CDK5 R-HSA-9032845
Activated NTRK2 signals through PI3K R-HSA-9028335
Signaling by NTRKs R-HSA-166520
Activated NTRK2 signals through FYN R-HSA-9032500
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
NTRK2 activates RAC1 R-HSA-9032759
Signal Transduction R-HSA-162582
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Activated NTRK2 signals through RAS R-HSA-9026519
Activation of TRKA receptors R-HSA-187015
Signaling by NTRK1 (TRKA) R-HSA-187037
NGF-independant TRKA activation R-HSA-187024
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activated NTRK2 signals through FYN R-HSA-9032500
Activated NTRK2 signals through CDK5 R-HSA-9032845
Signaling by NTRK1 (TRKA) R-HSA-187037
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
NTRK2 activates RAC1 R-HSA-9032759
Signal Transduction R-HSA-162582
Activated NTRK2 signals through PI3K R-HSA-9028335
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Activation of TRKA receptors R-HSA-187015
Activated NTRK2 signals through RAS R-HSA-9026519
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
NGF-independant TRKA activation R-HSA-187024
Signaling by NTRKs R-HSA-166520
Activated NTRK2 signals through PLCG1 R-HSA-9026527
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Activated NTRK2 signals through FYN R-HSA-9032500
Signaling by NTRKs R-HSA-166520
Signaling by NTRK1 (TRKA) R-HSA-187037
Activated NTRK2 signals through CDK5 R-HSA-9032845
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activated NTRK2 signals through RAS R-HSA-9026519
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Activated NTRK2 signals through PI3K R-HSA-9028335
Signal Transduction R-HSA-162582
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Activation of TRKA receptors R-HSA-187015
NGF-independant TRKA activation R-HSA-187024
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Activated NTRK2 signals through PLCG1 R-HSA-9026527
NTRK2 activates RAC1 R-HSA-9032759
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
NGF-independant TRKA activation R-HSA-187024
Activated NTRK2 signals through PLCG1 R-HSA-9026527
Signaling by NTRKs R-HSA-166520
Activated NTRK2 signals through CDK5 R-HSA-9032845
Signal Transduction R-HSA-162582
NTF4 activates NTRK2 (TRKB) signaling R-HSA-9026357
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
NTRK2 activates RAC1 R-HSA-9032759
BDNF activates NTRK2 (TRKB) signaling R-HSA-9024909
Activated NTRK2 signals through FYN R-HSA-9032500
NTF3 activates NTRK2 (TRKB) signaling R-HSA-9025046
Activated NTRK2 signals through RAS R-HSA-9026519
Signaling by NTRK2 (TRKB) R-HSA-9006115
Activation of TRKA receptors R-HSA-187015
Activated NTRK2 signals through PI3K R-HSA-9028335

Expression Atlas ENSG00000148053
NCBI gene (formerly Entrezgene) 4915
GeneCards 8032
HGNC Symbol HGNC:8032
MIM gene 600456
MIM morbid 617830
UniProtKB Gene Name Q5VWE5
WikiGene 4915
Gene: CDK4
Ensembl ID : ENSG00000135446
Description: cyclin dependent kinase 4
Gene Synonyms: PSK-J3
15 APIs:
227 Possible Orthologues:

Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Developmental Biology R-HSA-1266738
PTK6 Regulates Cell Cycle R-HSA-8849470
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
RMTs methylate histone arginines R-HSA-3214858
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Meiotic recombination R-HSA-912446
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Cellular responses to stimuli R-HSA-8953897
G1/S Transition R-HSA-69206
Disease R-HSA-1643685
Cell Cycle, Mitotic R-HSA-69278
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Transcriptional regulation of granulopoiesis R-HSA-9616222
Chromatin modifying enzymes R-HSA-3247509
Cell Cycle R-HSA-1640170
Cyclin E associated events during G1/S transition R-HSA-69202
Signal Transduction R-HSA-162582
G1 Phase R-HSA-69236
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Diseases of cellular response to stress R-HSA-9675132
Cellular responses to stress R-HSA-2262752
Oncogene Induced Senescence R-HSA-2559585
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Reproduction R-HSA-1474165
Diseases of mitotic cell cycle R-HSA-9675126
S Phase R-HSA-69242
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
RNA Polymerase II Transcription R-HSA-73857
Chromatin organization R-HSA-4839726
Diseases of Cellular Senescence R-HSA-9630747
Cyclin D associated events in G1 R-HSA-69231
Signaling by PTK6 R-HSA-8848021
Meiosis R-HSA-1500620
Oxidative Stress Induced Senescence R-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Cellular Senescence R-HSA-2559583
Generic Transcription Pathway R-HSA-212436
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Transcriptional regulation by RUNX2 R-HSA-8878166
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Gene expression (Transcription) R-HSA-74160
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Mitotic G1 phase and G1/S transition R-HSA-453279
Transcriptional regulation by RUNX2 R-HSA-8878166
Diseases of mitotic cell cycle R-HSA-9675126
Signal Transduction R-HSA-162582
Cyclin E associated events during G1/S transition R-HSA-69202
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
G1 Phase R-HSA-69236
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cellular responses to stimuli R-HSA-8953897
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Cell Cycle, Mitotic R-HSA-69278
Signaling by PTK6 R-HSA-8848021
Cell Cycle R-HSA-1640170
Oxidative Stress Induced Senescence R-HSA-2559580
G1/S Transition R-HSA-69206
Generic Transcription Pathway R-HSA-212436
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cyclin D associated events in G1 R-HSA-69231
Cellular Senescence R-HSA-2559583
Cellular responses to stress R-HSA-2262752
Developmental Biology R-HSA-1266738
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
PTK6 Regulates Cell Cycle R-HSA-8849470
Meiotic recombination R-HSA-912446
Transcriptional regulation of granulopoiesis R-HSA-9616222
Meiosis R-HSA-1500620
Mitotic G1 phase and G1/S transition R-HSA-453279
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
RMTs methylate histone arginines R-HSA-3214858
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Gene expression (Transcription) R-HSA-74160
Oncogene Induced Senescence R-HSA-2559585
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Disease R-HSA-1643685
S Phase R-HSA-69242
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Chromatin modifying enzymes R-HSA-3247509
Diseases of Cellular Senescence R-HSA-9630747
Chromatin organization R-HSA-4839726
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
RNA Polymerase II Transcription R-HSA-73857
Reproduction R-HSA-1474165
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Diseases of cellular response to stress R-HSA-9675132
Oxidative Stress Induced Senescence R-HSA-2559580
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Diseases of mitotic cell cycle R-HSA-9675126
Mitotic G1 phase and G1/S transition R-HSA-453279
Generic Transcription Pathway R-HSA-212436
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Disease R-HSA-1643685
Chromatin modifying enzymes R-HSA-3247509
Cyclin E associated events during G1/S transition R-HSA-69202
PTK6 Regulates Cell Cycle R-HSA-8849470
G1/S Transition R-HSA-69206
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cellular Senescence R-HSA-2559583
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Transcriptional regulation by RUNX2 R-HSA-8878166
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Chromatin organization R-HSA-4839726
Signal Transduction R-HSA-162582
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Diseases of cellular response to stress R-HSA-9675132
RMTs methylate histone arginines R-HSA-3214858
G1 Phase R-HSA-69236
Meiosis R-HSA-1500620
RNA Polymerase II Transcription R-HSA-73857
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Gene expression (Transcription) R-HSA-74160
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Signaling by PTK6 R-HSA-8848021
Cellular responses to stimuli R-HSA-8953897
Developmental Biology R-HSA-1266738
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Meiotic recombination R-HSA-912446
Reproduction R-HSA-1474165
Cyclin D associated events in G1 R-HSA-69231
Cell Cycle R-HSA-1640170
Transcriptional regulation of granulopoiesis R-HSA-9616222
Oncogene Induced Senescence R-HSA-2559585
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Diseases of Cellular Senescence R-HSA-9630747
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
S Phase R-HSA-69242
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Cell Cycle, Mitotic R-HSA-69278
Cellular responses to stress R-HSA-2262752
Reproduction R-HSA-1474165
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Gene expression (Transcription) R-HSA-74160
Diseases of mitotic cell cycle R-HSA-9675126
Mitotic G1 phase and G1/S transition R-HSA-453279
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
PTK6 Regulates Cell Cycle R-HSA-8849470
Signal Transduction R-HSA-162582
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Disease R-HSA-1643685
Oncogene Induced Senescence R-HSA-2559585
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Diseases of cellular response to stress R-HSA-9675132
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Diseases of Cellular Senescence R-HSA-9630747
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Chromatin organization R-HSA-4839726
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Cyclin D associated events in G1 R-HSA-69231
Meiosis R-HSA-1500620
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Transcriptional regulation of granulopoiesis R-HSA-9616222
RNA Polymerase II Transcription R-HSA-73857
Meiotic recombination R-HSA-912446
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
G1/S Transition R-HSA-69206
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
S Phase R-HSA-69242
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
RMTs methylate histone arginines R-HSA-3214858
Cell Cycle R-HSA-1640170
G1 Phase R-HSA-69236
Cellular Senescence R-HSA-2559583
Chromatin modifying enzymes R-HSA-3247509
Transcriptional regulation by RUNX2 R-HSA-8878166
Cyclin E associated events during G1/S transition R-HSA-69202
Cell Cycle, Mitotic R-HSA-69278
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Signaling by PTK6 R-HSA-8848021
Cellular responses to stress R-HSA-2262752
Developmental Biology R-HSA-1266738
Generic Transcription Pathway R-HSA-212436
Cyclin E associated events during G1/S transition R-HSA-69202
Developmental Biology R-HSA-1266738
S Phase R-HSA-69242
Reproduction R-HSA-1474165
Cyclin D associated events in G1 R-HSA-69231
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cell Cycle, Mitotic R-HSA-69278
Meiotic recombination R-HSA-912446
Diseases of cellular response to stress R-HSA-9675132
Transcriptional regulation of granulopoiesis R-HSA-9616222
Cellular responses to stress R-HSA-2262752
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Oncogene Induced Senescence R-HSA-2559585
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Cell Cycle R-HSA-1640170
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Diseases of Cellular Senescence R-HSA-9630747
Chromatin modifying enzymes R-HSA-3247509
Mitotic G1 phase and G1/S transition R-HSA-453279
Cellular Senescence R-HSA-2559583
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
G1 Phase R-HSA-69236
RMTs methylate histone arginines R-HSA-3214858
Signal Transduction R-HSA-162582
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
PTK6 Regulates Cell Cycle R-HSA-8849470
Transcriptional regulation by RUNX2 R-HSA-8878166
G1/S Transition R-HSA-69206
Diseases of mitotic cell cycle R-HSA-9675126
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Signaling by PTK6 R-HSA-8848021
Meiosis R-HSA-1500620
Cellular responses to stimuli R-HSA-8953897
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Chromatin organization R-HSA-4839726
Oxidative Stress Induced Senescence R-HSA-2559580
Gene expression (Transcription) R-HSA-74160
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Cyclin E associated events during G1/S transition R-HSA-69202
G1/S Transition R-HSA-69206
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cellular Senescence R-HSA-2559583
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
Reproduction R-HSA-1474165
Generic Transcription Pathway R-HSA-212436
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Meiosis R-HSA-1500620
Cell Cycle R-HSA-1640170
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Chromatin organization R-HSA-4839726
Cellular responses to stimuli R-HSA-8953897
G1 Phase R-HSA-69236
Diseases of mitotic cell cycle R-HSA-9675126
Diseases of cellular response to stress R-HSA-9675132
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Developmental Biology R-HSA-1266738
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Diseases of Cellular Senescence R-HSA-9630747
Cellular responses to stress R-HSA-2262752
Signaling by PTK6 R-HSA-8848021
Mitotic G1 phase and G1/S transition R-HSA-453279
Transcriptional regulation by RUNX2 R-HSA-8878166
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Oncogene Induced Senescence R-HSA-2559585
Transcriptional regulation of granulopoiesis R-HSA-9616222
Meiotic recombination R-HSA-912446
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Disease R-HSA-1643685
Chromatin modifying enzymes R-HSA-3247509
Oxidative Stress Induced Senescence R-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Cyclin D associated events in G1 R-HSA-69231
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cell Cycle, Mitotic R-HSA-69278
S Phase R-HSA-69242
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
PTK6 Regulates Cell Cycle R-HSA-8849470
RNA Polymerase II Transcription R-HSA-73857
RMTs methylate histone arginines R-HSA-3214858
Transcriptional regulation by RUNX2 R-HSA-8878166
G1/S Transition R-HSA-69206
Oncogene Induced Senescence R-HSA-2559585
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Gene expression (Transcription) R-HSA-74160
Mitotic G1 phase and G1/S transition R-HSA-453279
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
RMTs methylate histone arginines R-HSA-3214858
Reproduction R-HSA-1474165
Signal Transduction R-HSA-162582
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
Cellular responses to stress R-HSA-2262752
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cyclin E associated events during G1/S transition R-HSA-69202
Cyclin D associated events in G1 R-HSA-69231
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Chromatin organization R-HSA-4839726
PTK6 Regulates Cell Cycle R-HSA-8849470
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Diseases of cellular response to stress R-HSA-9675132
Developmental Biology R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Cellular Senescence R-HSA-2559583
Meiotic recombination R-HSA-912446
Cellular responses to stimuli R-HSA-8953897
Chromatin modifying enzymes R-HSA-3247509
Transcriptional regulation of granulopoiesis R-HSA-9616222
Meiosis R-HSA-1500620
Diseases of mitotic cell cycle R-HSA-9675126
Diseases of Cellular Senescence R-HSA-9630747
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Disease R-HSA-1643685
S Phase R-HSA-69242
Signaling by PTK6 R-HSA-8848021
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
G1 Phase R-HSA-69236
Oxidative Stress Induced Senescence R-HSA-2559580
Oxidative Stress Induced Senescence R-HSA-2559580
Diseases of cellular response to stress R-HSA-9675132
Cell Cycle, Mitotic R-HSA-69278
Meiosis R-HSA-1500620
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Diseases of Cellular Senescence R-HSA-9630747
S Phase R-HSA-69242
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by PTK6 R-HSA-8848021
G1/S Transition R-HSA-69206
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cellular Senescence R-HSA-2559583
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Mitotic G1 phase and G1/S transition R-HSA-453279
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Cell Cycle R-HSA-1640170
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Disease R-HSA-1643685
Cellular responses to stress R-HSA-2262752
Oncogene Induced Senescence R-HSA-2559585
Transcriptional regulation of granulopoiesis R-HSA-9616222
Chromatin organization R-HSA-4839726
Cyclin E associated events during G1/S transition R-HSA-69202
G1 Phase R-HSA-69236
Reproduction R-HSA-1474165
PTK6 Regulates Cell Cycle R-HSA-8849470
Chromatin modifying enzymes R-HSA-3247509
Meiotic recombination R-HSA-912446
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Cyclin D associated events in G1 R-HSA-69231
Developmental Biology R-HSA-1266738
RMTs methylate histone arginines R-HSA-3214858
RNA Polymerase II Transcription R-HSA-73857
Transcriptional regulation by RUNX2 R-HSA-8878166
Generic Transcription Pathway R-HSA-212436
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cellular responses to stimuli R-HSA-8953897
Diseases of mitotic cell cycle R-HSA-9675126
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Gene expression (Transcription) R-HSA-74160
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Signaling by PTK6 R-HSA-8848021
Developmental Biology R-HSA-1266738
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
PTK6 Regulates Cell Cycle R-HSA-8849470
Cyclin E associated events during G1/S transition R-HSA-69202
Meiotic recombination R-HSA-912446
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle, Mitotic R-HSA-69278
Oxidative Stress Induced Senescence R-HSA-2559580
Chromatin modifying enzymes R-HSA-3247509
Reproduction R-HSA-1474165
Diseases of Cellular Senescence R-HSA-9630747
S Phase R-HSA-69242
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
G1 Phase R-HSA-69236
Cellular responses to stimuli R-HSA-8953897
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Transcriptional regulation of granulopoiesis R-HSA-9616222
RNA Polymerase II Transcription R-HSA-73857
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Cellular Senescence R-HSA-2559583
Diseases of mitotic cell cycle R-HSA-9675126
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cell Cycle R-HSA-1640170
Cellular responses to stress R-HSA-2262752
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
Meiosis R-HSA-1500620
RMTs methylate histone arginines R-HSA-3214858
Chromatin organization R-HSA-4839726
Signal Transduction R-HSA-162582
Oncogene Induced Senescence R-HSA-2559585
Diseases of cellular response to stress R-HSA-9675132
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
G1/S Transition R-HSA-69206
Cyclin D associated events in G1 R-HSA-69231
Transcriptional regulation by RUNX2 R-HSA-8878166
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cell Cycle R-HSA-1640170
Meiosis R-HSA-1500620
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Evasion of Oncogene Induced Senescence Due to p16INK4A Defects R-HSA-9630750
Diseases of Cellular Senescence R-HSA-9630747
Cell Cycle, Mitotic R-HSA-69278
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9630794
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cyclin D associated events in G1 R-HSA-69231
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9630791
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Oncogene Induced Senescence R-HSA-2559585
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 R-HSA-9632700
RNA Polymerase II Transcription R-HSA-73857
RMTs methylate histone arginines R-HSA-3214858
PTK6 Regulates Cell Cycle R-HSA-8849470
G1 Phase R-HSA-69236
Gene expression (Transcription) R-HSA-74160
Chromatin organization R-HSA-4839726
Drug-mediated inhibition of CDK4/CDK6 activity R-HSA-9754119
S Phase R-HSA-69242
Meiotic recombination R-HSA-912446
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Transcriptional regulation by RUNX2 R-HSA-8878166
G1/S Transition R-HSA-69206
Transcriptional regulation of white adipocyte differentiation R-HSA-381340
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Transcriptional regulation of granulopoiesis R-HSA-9616222
Chromatin modifying enzymes R-HSA-3247509
Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects R-HSA-9632693
Reproduction R-HSA-1474165
Developmental Biology R-HSA-1266738
Signaling by PTK6 R-HSA-8848021
Cellular Senescence R-HSA-2559583
Diseases of cellular response to stress R-HSA-9675132
Cellular responses to stress R-HSA-2262752
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 R-HSA-9632697
Signal Transduction R-HSA-162582
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Mitotic G1 phase and G1/S transition R-HSA-453279
Oxidative Stress Induced Senescence R-HSA-2559580
Generic Transcription Pathway R-HSA-212436
Cyclin E associated events during G1/S transition R-HSA-69202
Cellular responses to stimuli R-HSA-8953897
Diseases of mitotic cell cycle R-HSA-9675126
Disease R-HSA-1643685

Expression Atlas ENSG00000135446
LRG display in Ensembl gene LRG_490
NCBI gene (formerly Entrezgene) 1019
GeneCards 1773
HGNC Symbol HGNC:1773
MIM gene 123829
MIM morbid 609048
UniProtKB Gene Name Q96BE9
WikiGene 1019
Gene: LCK
Ensembl ID : ENSG00000182866
Description: LCK proto-oncogene, Src family tyrosine kinase
Gene Synonyms:
2 APIs:
120 Possible Orthologues:

Generation of second messenger molecules R-HSA-202433
Negative regulation of the PI3K/AKT network R-HSA-199418
Cell surface interactions at the vascular wall R-HSA-202733
Infectious disease R-HSA-5663205
Adaptive Immune System R-HSA-1280218
GPVI-mediated activation cascade R-HSA-114604
CD28 co-stimulation R-HSA-389356
Intracellular signaling by second messengers R-HSA-9006925
Platelet activation, signaling and aggregation R-HSA-76002
FLT3 signaling through SRC family kinases R-HSA-9706374
Interleukin-2 signaling R-HSA-9020558
Immune System R-HSA-168256
CD28 dependent PI3K/Akt signaling R-HSA-389357
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Host Interactions of HIV factors R-HSA-162909
RHOH GTPase cycle R-HSA-9013407
TCR signaling R-HSA-202403
Costimulation by the CD28 family R-HSA-388841
Signaling by KIT in disease R-HSA-9669938
DAP12 interactions R-HSA-2172127
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cytokine Signaling in Immune system R-HSA-1280215
Nef and signal transduction R-HSA-164944
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
RHO GTPase cycle R-HSA-9012999
Interleukin-2 family signaling R-HSA-451927
Nef Mediated CD4 Down-regulation R-HSA-167590
Signaling by Rho GTPases R-HSA-194315
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
HIV Infection R-HSA-162906
Signal Transduction R-HSA-162582
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
PD-1 signaling R-HSA-389948
PIP3 activates AKT signaling R-HSA-1257604
Regulation of KIT signaling R-HSA-1433559
Hemostasis R-HSA-109582
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Downstream TCR signaling R-HSA-202424
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
CD28 dependent Vav1 pathway R-HSA-389359
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by SCF-KIT R-HSA-1433557
FLT3 Signaling R-HSA-9607240
DAP12 signaling R-HSA-2424491
CTLA4 inhibitory signaling R-HSA-389513
PECAM1 interactions R-HSA-210990
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
RHO GTPase cycle R-HSA-9012999
Nef Mediated CD4 Down-regulation R-HSA-167590
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Infectious disease R-HSA-5663205
Signaling by SCF-KIT R-HSA-1433557
PIP3 activates AKT signaling R-HSA-1257604
Immune System R-HSA-168256
Signaling by Rho GTPases R-HSA-194315
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Negative regulation of the PI3K/AKT network R-HSA-199418
PECAM1 interactions R-HSA-210990
FLT3 Signaling R-HSA-9607240
Intracellular signaling by second messengers R-HSA-9006925
Costimulation by the CD28 family R-HSA-388841
PD-1 signaling R-HSA-389948
Generation of second messenger molecules R-HSA-202433
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
RHOH GTPase cycle R-HSA-9013407
Adaptive Immune System R-HSA-1280218
Signaling by KIT in disease R-HSA-9669938
TCR signaling R-HSA-202403
DAP12 signaling R-HSA-2424491
Interleukin-2 family signaling R-HSA-451927
Innate Immune System R-HSA-168249
GPVI-mediated activation cascade R-HSA-114604
Signal Transduction R-HSA-162582
Downstream TCR signaling R-HSA-202424
CD28 dependent Vav1 pathway R-HSA-389359
Interleukin-2 signaling R-HSA-9020558
PI3K/AKT Signaling in Cancer R-HSA-2219528
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Platelet activation, signaling and aggregation R-HSA-76002
CD28 dependent PI3K/Akt signaling R-HSA-389357
CD28 co-stimulation R-HSA-389356
Hemostasis R-HSA-109582
Host Interactions of HIV factors R-HSA-162909
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cell surface interactions at the vascular wall R-HSA-202733
Disease R-HSA-1643685
Signaling by Interleukins R-HSA-449147
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Regulation of KIT signaling R-HSA-1433559
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
HIV Infection R-HSA-162906
Nef and signal transduction R-HSA-164944
FLT3 signaling through SRC family kinases R-HSA-9706374
CTLA4 inhibitory signaling R-HSA-389513
DAP12 interactions R-HSA-2172127
CTLA4 inhibitory signaling R-HSA-389513
CD28 dependent Vav1 pathway R-HSA-389359
Host Interactions of HIV factors R-HSA-162909
GPVI-mediated activation cascade R-HSA-114604
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
DAP12 interactions R-HSA-2172127
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by KIT in disease R-HSA-9669938
Nef Mediated CD4 Down-regulation R-HSA-167590
Hemostasis R-HSA-109582
RHOH GTPase cycle R-HSA-9013407
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Signal Transduction R-HSA-162582
DAP12 signaling R-HSA-2424491
Interleukin-2 family signaling R-HSA-451927
Intracellular signaling by second messengers R-HSA-9006925
PECAM1 interactions R-HSA-210990
PD-1 signaling R-HSA-389948
Interleukin-2 signaling R-HSA-9020558
Generation of second messenger molecules R-HSA-202433
FLT3 Signaling R-HSA-9607240
RHO GTPase cycle R-HSA-9012999
Adaptive Immune System R-HSA-1280218
Nef and signal transduction R-HSA-164944
CD28 dependent PI3K/Akt signaling R-HSA-389357
Regulation of KIT signaling R-HSA-1433559
HIV Infection R-HSA-162906
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
PI3K/AKT Signaling in Cancer R-HSA-2219528
Infectious disease R-HSA-5663205
TCR signaling R-HSA-202403
Cell surface interactions at the vascular wall R-HSA-202733
Innate Immune System R-HSA-168249
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream TCR signaling R-HSA-202424
Signaling by SCF-KIT R-HSA-1433557
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Costimulation by the CD28 family R-HSA-388841
Immune System R-HSA-168256
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Interleukins R-HSA-449147
FLT3 signaling through SRC family kinases R-HSA-9706374
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Disease R-HSA-1643685
Signaling by Rho GTPases R-HSA-194315
CD28 co-stimulation R-HSA-389356
Hemostasis R-HSA-109582
Interleukin-2 signaling R-HSA-9020558
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nef and signal transduction R-HSA-164944
CD28 co-stimulation R-HSA-389356
PIP3 activates AKT signaling R-HSA-1257604
PI3K/AKT Signaling in Cancer R-HSA-2219528
Adaptive Immune System R-HSA-1280218
FLT3 signaling through SRC family kinases R-HSA-9706374
Signaling by SCF-KIT R-HSA-1433557
CTLA4 inhibitory signaling R-HSA-389513
Cell surface interactions at the vascular wall R-HSA-202733
HIV Infection R-HSA-162906
Platelet activation, signaling and aggregation R-HSA-76002
RHO GTPase cycle R-HSA-9012999
Costimulation by the CD28 family R-HSA-388841
Signaling by Interleukins R-HSA-449147
RHOH GTPase cycle R-HSA-9013407
GPVI-mediated activation cascade R-HSA-114604
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Immune System R-HSA-168256
CD28 dependent Vav1 pathway R-HSA-389359
Negative regulation of the PI3K/AKT network R-HSA-199418
DAP12 signaling R-HSA-2424491
PECAM1 interactions R-HSA-210990
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream TCR signaling R-HSA-202424
Generation of second messenger molecules R-HSA-202433
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
TCR signaling R-HSA-202403
Regulation of KIT signaling R-HSA-1433559
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Intracellular signaling by second messengers R-HSA-9006925
Signaling by KIT in disease R-HSA-9669938
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
FLT3 Signaling R-HSA-9607240
Signaling by Rho GTPases R-HSA-194315
Host Interactions of HIV factors R-HSA-162909
Infectious disease R-HSA-5663205
Interleukin-2 family signaling R-HSA-451927
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Nef Mediated CD4 Down-regulation R-HSA-167590
PD-1 signaling R-HSA-389948
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Innate Immune System R-HSA-168249
DAP12 interactions R-HSA-2172127
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
CD28 dependent Vav1 pathway R-HSA-389359
DAP12 interactions R-HSA-2172127
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Infectious disease R-HSA-5663205
Host Interactions of HIV factors R-HSA-162909
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHO GTPase cycle R-HSA-9012999
Interleukin-2 family signaling R-HSA-451927
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Intracellular signaling by second messengers R-HSA-9006925
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Nef and signal transduction R-HSA-164944
Cell surface interactions at the vascular wall R-HSA-202733
Nef Mediated CD4 Down-regulation R-HSA-167590
PD-1 signaling R-HSA-389948
Signaling by SCF-KIT R-HSA-1433557
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Signaling by KIT in disease R-HSA-9669938
GPVI-mediated activation cascade R-HSA-114604
HIV Infection R-HSA-162906
RHOH GTPase cycle R-HSA-9013407
Adaptive Immune System R-HSA-1280218
Downstream TCR signaling R-HSA-202424
PIP3 activates AKT signaling R-HSA-1257604
Regulation of KIT signaling R-HSA-1433559
FLT3 signaling through SRC family kinases R-HSA-9706374
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
PI3K/AKT Signaling in Cancer R-HSA-2219528
FLT3 Signaling R-HSA-9607240
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Costimulation by the CD28 family R-HSA-388841
Platelet activation, signaling and aggregation R-HSA-76002
Hemostasis R-HSA-109582
Signaling by Interleukins R-HSA-449147
Signaling by Rho GTPases R-HSA-194315
Interleukin-2 signaling R-HSA-9020558
CTLA4 inhibitory signaling R-HSA-389513
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
CD28 dependent PI3K/Akt signaling R-HSA-389357
TCR signaling R-HSA-202403
Signal Transduction R-HSA-162582
PECAM1 interactions R-HSA-210990
Generation of second messenger molecules R-HSA-202433
Cytokine Signaling in Immune system R-HSA-1280215
DAP12 signaling R-HSA-2424491
CD28 co-stimulation R-HSA-389356
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nef Mediated CD4 Down-regulation R-HSA-167590
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Cytokine Signaling in Immune system R-HSA-1280215
DAP12 interactions R-HSA-2172127
Nef and signal transduction R-HSA-164944
Negative regulation of the PI3K/AKT network R-HSA-199418
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
CD28 dependent PI3K/Akt signaling R-HSA-389357
GPVI-mediated activation cascade R-HSA-114604
RHO GTPase cycle R-HSA-9012999
DAP12 signaling R-HSA-2424491
TCR signaling R-HSA-202403
Signaling by Interleukins R-HSA-449147
FLT3 Signaling R-HSA-9607240
Cell surface interactions at the vascular wall R-HSA-202733
FLT3 signaling through SRC family kinases R-HSA-9706374
Adaptive Immune System R-HSA-1280218
Hemostasis R-HSA-109582
Signaling by Rho GTPases R-HSA-194315
Interleukin-2 family signaling R-HSA-451927
CD28 dependent Vav1 pathway R-HSA-389359
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
HIV Infection R-HSA-162906
Signaling by KIT in disease R-HSA-9669938
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Interleukin-2 signaling R-HSA-9020558
PD-1 signaling R-HSA-389948
Generation of second messenger molecules R-HSA-202433
CD28 co-stimulation R-HSA-389356
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
PECAM1 interactions R-HSA-210990
RHOH GTPase cycle R-HSA-9013407
Downstream TCR signaling R-HSA-202424
Host Interactions of HIV factors R-HSA-162909
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Signaling by SCF-KIT R-HSA-1433557
Disease R-HSA-1643685
Costimulation by the CD28 family R-HSA-388841
CTLA4 inhibitory signaling R-HSA-389513
Immune System R-HSA-168256
Platelet activation, signaling and aggregation R-HSA-76002
Regulation of KIT signaling R-HSA-1433559
DAP12 interactions R-HSA-2172127
Costimulation by the CD28 family R-HSA-388841
Cell surface interactions at the vascular wall R-HSA-202733
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
RHO GTPase cycle R-HSA-9012999
CTLA4 inhibitory signaling R-HSA-389513
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Nef and signal transduction R-HSA-164944
Signaling by KIT in disease R-HSA-9669938
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Rho GTPases R-HSA-194315
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
PD-1 signaling R-HSA-389948
Platelet activation, signaling and aggregation R-HSA-76002
Immune System R-HSA-168256
Signaling by SCF-KIT R-HSA-1433557
TCR signaling R-HSA-202403
Adaptive Immune System R-HSA-1280218
Regulation of KIT signaling R-HSA-1433559
Cytokine Signaling in Immune system R-HSA-1280215
Disease R-HSA-1643685
PI3K/AKT Signaling in Cancer R-HSA-2219528
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Infectious disease R-HSA-5663205
Signaling by Interleukins R-HSA-449147
Interleukin-2 signaling R-HSA-9020558
Signal Transduction R-HSA-162582
HIV Infection R-HSA-162906
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Hemostasis R-HSA-109582
Generation of second messenger molecules R-HSA-202433
Intracellular signaling by second messengers R-HSA-9006925
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Interleukin-2 family signaling R-HSA-451927
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
CD28 dependent Vav1 pathway R-HSA-389359
RHOH GTPase cycle R-HSA-9013407
Innate Immune System R-HSA-168249
FLT3 Signaling R-HSA-9607240
FLT3 signaling through SRC family kinases R-HSA-9706374
GPVI-mediated activation cascade R-HSA-114604
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Downstream TCR signaling R-HSA-202424
Nef Mediated CD4 Down-regulation R-HSA-167590
Host Interactions of HIV factors R-HSA-162909
CD28 co-stimulation R-HSA-389356
DAP12 signaling R-HSA-2424491
PECAM1 interactions R-HSA-210990
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Downstream TCR signaling R-HSA-202424
GPVI-mediated activation cascade R-HSA-114604
Negative regulation of the PI3K/AKT network R-HSA-199418
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Signaling by SCF-KIT R-HSA-1433557
Signal Transduction R-HSA-162582
Innate Immune System R-HSA-168249
Hemostasis R-HSA-109582
Infectious disease R-HSA-5663205
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Generation of second messenger molecules R-HSA-202433
CD28 dependent Vav1 pathway R-HSA-389359
Interleukin-2 family signaling R-HSA-451927
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by KIT in disease R-HSA-9669938
Cytokine Signaling in Immune system R-HSA-1280215
PI3K/AKT Signaling in Cancer R-HSA-2219528
DAP12 interactions R-HSA-2172127
Intracellular signaling by second messengers R-HSA-9006925
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Immune System R-HSA-168256
FLT3 signaling through SRC family kinases R-HSA-9706374
Interleukin-2 signaling R-HSA-9020558
CTLA4 inhibitory signaling R-HSA-389513
PECAM1 interactions R-HSA-210990
PIP3 activates AKT signaling R-HSA-1257604
Host Interactions of HIV factors R-HSA-162909
Adaptive Immune System R-HSA-1280218
CD28 co-stimulation R-HSA-389356
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Cell surface interactions at the vascular wall R-HSA-202733
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HIV Infection R-HSA-162906
Signaling by Rho GTPases R-HSA-194315
Nef and signal transduction R-HSA-164944
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by Interleukins R-HSA-449147
Costimulation by the CD28 family R-HSA-388841
Disease R-HSA-1643685
CD28 dependent PI3K/Akt signaling R-HSA-389357
Nef Mediated CD4 Down-regulation R-HSA-167590
FLT3 Signaling R-HSA-9607240
Regulation of KIT signaling R-HSA-1433559
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
RHO GTPase cycle R-HSA-9012999
PD-1 signaling R-HSA-389948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOH GTPase cycle R-HSA-9013407
TCR signaling R-HSA-202403
DAP12 signaling R-HSA-2424491

Expression Atlas ENSG00000182866
LRG display in Ensembl gene LRG_153
NCBI gene (formerly Entrezgene) 3932
GeneCards 6524
HGNC Symbol HGNC:6524
MIM gene 153390
MIM morbid 615758
UniProtKB Gene Name P06239
WikiGene 3932