Gene: APP
Ensembl ID : ENSG00000142192
Description: amyloid beta precursor protein
Gene Synonyms: AD1,ALPHA-SAPP
11 APIs:
279 Possible Orthologues:

Hemostasis R-HSA-109582
Signaling by Interleukins R-HSA-449147
Metabolism of proteins R-HSA-392499
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
MyD88 dependent cascade initiated on endosome R-HSA-975155
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Signal Transduction R-HSA-162582
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Post-translational protein modification R-HSA-597592
Protein localization R-HSA-9609507
Inflammasomes R-HSA-622312
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Platelet degranulation R-HSA-114608
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
The NLRP3 inflammasome R-HSA-844456
Peptide ligand-binding receptors R-HSA-375276
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Cytokine Signaling in Immune system R-HSA-1280215
GPCR ligand binding R-HSA-500792
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Interleukin-1 signaling R-HSA-9020702
Post-translational protein phosphorylation R-HSA-8957275
Diseases of programmed cell death R-HSA-9645723
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Membrane Trafficking R-HSA-199991
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
trans-Golgi Network Vesicle Budding R-HSA-199992
Interleukin-1 family signaling R-HSA-446652
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
Infectious disease R-HSA-5663205
Leishmania infection R-HSA-9658195
Neurodegenerative Diseases R-HSA-8863678
MyD88-independent TLR4 cascade R-HSA-166166
Vesicle-mediated transport R-HSA-5653656
Platelet activation, signaling and aggregation R-HSA-76002
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Lysosome Vesicle Biogenesis R-HSA-432720
Immune System R-HSA-168256
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Extracellular matrix organization R-HSA-1474244
Innate Immune System R-HSA-168249
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Amyloid fiber formation R-HSA-977225
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
ECM proteoglycans R-HSA-3000178
Disease R-HSA-1643685
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
TRAF6 mediated NF-kB activation R-HSA-933542
G alpha (i) signalling events R-HSA-418594
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
trans-Golgi Network Vesicle Budding R-HSA-199992
GPCR ligand binding R-HSA-500792
Interleukin-1 family signaling R-HSA-446652
Signaling by Interleukins R-HSA-449147
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
The NLRP3 inflammasome R-HSA-844456
Cytokine Signaling in Immune system R-HSA-1280215
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Extracellular matrix organization R-HSA-1474244
Membrane Trafficking R-HSA-199991
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Infectious disease R-HSA-5663205
Signaling by GPCR R-HSA-372790
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Neurodegenerative Diseases R-HSA-8863678
Innate Immune System R-HSA-168249
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Toll-like Receptor Cascades R-HSA-168898
Post-translational protein modification R-HSA-597592
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
ECM proteoglycans R-HSA-3000178
Lysosome Vesicle Biogenesis R-HSA-432720
Platelet activation, signaling and aggregation R-HSA-76002
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Platelet degranulation R-HSA-114608
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
GPCR downstream signalling R-HSA-388396
G alpha (q) signalling events R-HSA-416476
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
MyD88 dependent cascade initiated on endosome R-HSA-975155
Amyloid fiber formation R-HSA-977225
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Inflammasomes R-HSA-622312
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Post-translational protein phosphorylation R-HSA-8957275
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
G alpha (i) signalling events R-HSA-418594
MyD88 cascade initiated on plasma membrane R-HSA-975871
Protein localization R-HSA-9609507
Immune System R-HSA-168256
Diseases of programmed cell death R-HSA-9645723
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signal Transduction R-HSA-162582
Vesicle-mediated transport R-HSA-5653656
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
Hemostasis R-HSA-109582
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Peptide ligand-binding receptors R-HSA-375276
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Interleukin-1 signaling R-HSA-9020702
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Purinergic signaling in leishmaniasis infection R-HSA-9660826
TRAF6 mediated NF-kB activation R-HSA-933542
Metabolism of proteins R-HSA-392499
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88-independent TLR4 cascade R-HSA-166166
Platelet activation, signaling and aggregation R-HSA-76002
G alpha (q) signalling events R-HSA-416476
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Signaling by Interleukins R-HSA-449147
G alpha (i) signalling events R-HSA-418594
ECM proteoglycans R-HSA-3000178
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Interleukin-1 signaling R-HSA-9020702
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Amyloid fiber formation R-HSA-977225
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Neurodegenerative Diseases R-HSA-8863678
Lysosome Vesicle Biogenesis R-HSA-432720
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
trans-Golgi Network Vesicle Budding R-HSA-199992
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Post-translational protein modification R-HSA-597592
Inflammasomes R-HSA-622312
Signaling by GPCR R-HSA-372790
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet degranulation R-HSA-114608
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Post-translational protein phosphorylation R-HSA-8957275
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Immune System R-HSA-168256
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
Vesicle-mediated transport R-HSA-5653656
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Interleukin-1 family signaling R-HSA-446652
Infectious disease R-HSA-5663205
MyD88 cascade initiated on plasma membrane R-HSA-975871
Protein localization R-HSA-9609507
Peptide ligand-binding receptors R-HSA-375276
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Leishmania infection R-HSA-9658195
MyD88-independent TLR4 cascade R-HSA-166166
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
GPCR ligand binding R-HSA-500792
Hemostasis R-HSA-109582
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Disease R-HSA-1643685
TRAF6 mediated NF-kB activation R-HSA-933542
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Innate Immune System R-HSA-168249
The NLRP3 inflammasome R-HSA-844456
Membrane Trafficking R-HSA-199991
Metabolism of proteins R-HSA-392499
Extracellular matrix organization R-HSA-1474244
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
Cytokine Signaling in Immune system R-HSA-1280215
Diseases of programmed cell death R-HSA-9645723
MyD88 dependent cascade initiated on endosome R-HSA-975155
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Disease R-HSA-1643685
Neurodegenerative Diseases R-HSA-8863678
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by Interleukins R-HSA-449147
Extracellular matrix organization R-HSA-1474244
Amyloid fiber formation R-HSA-977225
Toll-like Receptor Cascades R-HSA-168898
Immune System R-HSA-168256
G alpha (q) signalling events R-HSA-416476
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
Membrane Trafficking R-HSA-199991
Leishmania infection R-HSA-9658195
GPCR downstream signalling R-HSA-388396
Interleukin-1 signaling R-HSA-9020702
MyD88 cascade initiated on plasma membrane R-HSA-975871
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Platelet activation, signaling and aggregation R-HSA-76002
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TRAF6 mediated NF-kB activation R-HSA-933542
Signaling by GPCR R-HSA-372790
Interleukin-1 family signaling R-HSA-446652
Platelet degranulation R-HSA-114608
Cytokine Signaling in Immune system R-HSA-1280215
Hemostasis R-HSA-109582
Diseases of programmed cell death R-HSA-9645723
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Peptide ligand-binding receptors R-HSA-375276
Metabolism of proteins R-HSA-392499
GPCR ligand binding R-HSA-500792
Vesicle-mediated transport R-HSA-5653656
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
G alpha (i) signalling events R-HSA-418594
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Purinergic signaling in leishmaniasis infection R-HSA-9660826
ECM proteoglycans R-HSA-3000178
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Innate Immune System R-HSA-168249
Inflammasomes R-HSA-622312
Post-translational protein modification R-HSA-597592
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Protein localization R-HSA-9609507
Infectious disease R-HSA-5663205
trans-Golgi Network Vesicle Budding R-HSA-199992
MyD88-independent TLR4 cascade R-HSA-166166
The NLRP3 inflammasome R-HSA-844456
Post-translational protein phosphorylation R-HSA-8957275
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signal Transduction R-HSA-162582
MyD88 dependent cascade initiated on endosome R-HSA-975155
Lysosome Vesicle Biogenesis R-HSA-432720
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
Inflammasomes R-HSA-622312
Leishmania infection R-HSA-9658195
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Cytokine Signaling in Immune system R-HSA-1280215
GPCR downstream signalling R-HSA-388396
Neurodegenerative Diseases R-HSA-8863678
Post-translational protein phosphorylation R-HSA-8957275
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Hemostasis R-HSA-109582
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll-like Receptor Cascades R-HSA-168898
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
Signaling by GPCR R-HSA-372790
Infectious disease R-HSA-5663205
MyD88 dependent cascade initiated on endosome R-HSA-975155
ECM proteoglycans R-HSA-3000178
Protein localization R-HSA-9609507
Innate Immune System R-HSA-168249
G alpha (i) signalling events R-HSA-418594
Peptide ligand-binding receptors R-HSA-375276
Extracellular matrix organization R-HSA-1474244
Vesicle-mediated transport R-HSA-5653656
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Interleukin-1 signaling R-HSA-9020702
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Immune System R-HSA-168256
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
GPCR ligand binding R-HSA-500792
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet activation, signaling and aggregation R-HSA-76002
Post-translational protein modification R-HSA-597592
MyD88 cascade initiated on plasma membrane R-HSA-975871
G alpha (q) signalling events R-HSA-416476
MyD88-independent TLR4 cascade R-HSA-166166
Advanced glycosylation endproduct receptor signaling R-HSA-879415
The NLRP3 inflammasome R-HSA-844456
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Membrane Trafficking R-HSA-199991
Signaling by Interleukins R-HSA-449147
Interleukin-1 family signaling R-HSA-446652
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
TRAF6 mediated NF-kB activation R-HSA-933542
Metabolism of proteins R-HSA-392499
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Lysosome Vesicle Biogenesis R-HSA-432720
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
trans-Golgi Network Vesicle Budding R-HSA-199992
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Platelet degranulation R-HSA-114608
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Diseases of programmed cell death R-HSA-9645723
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Amyloid fiber formation R-HSA-977225
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Metabolism of proteins R-HSA-392499
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Post-translational protein modification R-HSA-597592
Signaling by GPCR R-HSA-372790
Immune System R-HSA-168256
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Protein localization R-HSA-9609507
MyD88 cascade initiated on plasma membrane R-HSA-975871
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
ECM proteoglycans R-HSA-3000178
Lysosome Vesicle Biogenesis R-HSA-432720
Inflammasomes R-HSA-622312
MyD88 dependent cascade initiated on endosome R-HSA-975155
Extracellular matrix organization R-HSA-1474244
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
G alpha (i) signalling events R-HSA-418594
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Leishmania infection R-HSA-9658195
Disease R-HSA-1643685
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Signal Transduction R-HSA-162582
Hemostasis R-HSA-109582
Innate Immune System R-HSA-168249
Amyloid fiber formation R-HSA-977225
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Infectious disease R-HSA-5663205
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
G alpha (q) signalling events R-HSA-416476
Toll-like Receptor Cascades R-HSA-168898
GPCR ligand binding R-HSA-500792
Membrane Trafficking R-HSA-199991
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Interleukin-1 signaling R-HSA-9020702
Neurodegenerative Diseases R-HSA-8863678
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
Vesicle-mediated transport R-HSA-5653656
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
trans-Golgi Network Vesicle Budding R-HSA-199992
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
Post-translational protein phosphorylation R-HSA-8957275
MyD88-independent TLR4 cascade R-HSA-166166
Signaling by Interleukins R-HSA-449147
The NLRP3 inflammasome R-HSA-844456
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Diseases of programmed cell death R-HSA-9645723
TRAF6 mediated NF-kB activation R-HSA-933542
Interleukin-1 family signaling R-HSA-446652
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet degranulation R-HSA-114608
Advanced glycosylation endproduct receptor signaling R-HSA-879415
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Platelet activation, signaling and aggregation R-HSA-76002
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Disease R-HSA-1643685
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Interleukin-1 family signaling R-HSA-446652
Neurodegenerative Diseases R-HSA-8863678
Inflammasomes R-HSA-622312
GPCR downstream signalling R-HSA-388396
Amyloid fiber formation R-HSA-977225
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Extracellular matrix organization R-HSA-1474244
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
G alpha (q) signalling events R-HSA-416476
Protein localization R-HSA-9609507
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Platelet degranulation R-HSA-114608
Post-translational protein modification R-HSA-597592
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
GPCR ligand binding R-HSA-500792
MyD88-independent TLR4 cascade R-HSA-166166
Metabolism of proteins R-HSA-392499
TRAF6 mediated NF-kB activation R-HSA-933542
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
G alpha (i) signalling events R-HSA-418594
Leishmania infection R-HSA-9658195
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Signaling by Interleukins R-HSA-449147
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Immune System R-HSA-168256
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Membrane Trafficking R-HSA-199991
Cytokine Signaling in Immune system R-HSA-1280215
Vesicle-mediated transport R-HSA-5653656
Toll-like Receptor Cascades R-HSA-168898
Peptide ligand-binding receptors R-HSA-375276
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Lysosome Vesicle Biogenesis R-HSA-432720
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Diseases of programmed cell death R-HSA-9645723
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Cell recruitment (pro-inflammatory response) R-HSA-9664424
ECM proteoglycans R-HSA-3000178
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Hemostasis R-HSA-109582
Interleukin-1 signaling R-HSA-9020702
Post-translational protein phosphorylation R-HSA-8957275
MyD88 cascade initiated on plasma membrane R-HSA-975871
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
trans-Golgi Network Vesicle Budding R-HSA-199992
The NLRP3 inflammasome R-HSA-844456
Platelet activation, signaling and aggregation R-HSA-76002
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
The NLRP3 inflammasome R-HSA-844456
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Infectious disease R-HSA-5663205
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Vesicle-mediated transport R-HSA-5653656
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
GPCR downstream signalling R-HSA-388396
Purinergic signaling in leishmaniasis infection R-HSA-9660826
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Lysosome Vesicle Biogenesis R-HSA-432720
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Membrane Trafficking R-HSA-199991
Amyloid fiber formation R-HSA-977225
Immune System R-HSA-168256
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Cytokine Signaling in Immune system R-HSA-1280215
Inflammasomes R-HSA-622312
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
MyD88 cascade initiated on plasma membrane R-HSA-975871
GPCR ligand binding R-HSA-500792
Leishmania infection R-HSA-9658195
Interleukin-1 signaling R-HSA-9020702
Signal Transduction R-HSA-162582
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
Protein localization R-HSA-9609507
Interleukin-1 family signaling R-HSA-446652
Disease R-HSA-1643685
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Peptide ligand-binding receptors R-HSA-375276
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
TRAF6 mediated NF-kB activation R-HSA-933542
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Platelet degranulation R-HSA-114608
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Platelet activation, signaling and aggregation R-HSA-76002
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Post-translational protein modification R-HSA-597592
ECM proteoglycans R-HSA-3000178
G alpha (q) signalling events R-HSA-416476
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Neurodegenerative Diseases R-HSA-8863678
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Hemostasis R-HSA-109582
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
trans-Golgi Network Vesicle Budding R-HSA-199992
Extracellular matrix organization R-HSA-1474244
Metabolism of proteins R-HSA-392499
Innate Immune System R-HSA-168249
Diseases of programmed cell death R-HSA-9645723
Post-translational protein phosphorylation R-HSA-8957275
Vesicle-mediated transport R-HSA-5653656
Hemostasis R-HSA-109582
Peptide ligand-binding receptors R-HSA-375276
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Lysosome Vesicle Biogenesis R-HSA-432720
Membrane Trafficking R-HSA-199991
Post-translational protein phosphorylation R-HSA-8957275
Interleukin-1 family signaling R-HSA-446652
Toll-like Receptor Cascades R-HSA-168898
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Signaling by Interleukins R-HSA-449147
Signal Transduction R-HSA-162582
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Innate Immune System R-HSA-168249
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
The NLRP3 inflammasome R-HSA-844456
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Inflammasomes R-HSA-622312
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Diseases of programmed cell death R-HSA-9645723
GPCR downstream signalling R-HSA-388396
Purinergic signaling in leishmaniasis infection R-HSA-9660826
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Extracellular matrix organization R-HSA-1474244
Advanced glycosylation endproduct receptor signaling R-HSA-879415
G alpha (i) signalling events R-HSA-418594
Amyloid fiber formation R-HSA-977225
MyD88-independent TLR4 cascade R-HSA-166166
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Protein localization R-HSA-9609507
Immune System R-HSA-168256
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Interleukin-1 signaling R-HSA-9020702
Leishmania infection R-HSA-9658195
MyD88 dependent cascade initiated on endosome R-HSA-975155
Neurodegenerative Diseases R-HSA-8863678
Post-translational protein modification R-HSA-597592
MyD88 cascade initiated on plasma membrane R-HSA-975871
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Platelet activation, signaling and aggregation R-HSA-76002
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Platelet degranulation R-HSA-114608
Signaling by GPCR R-HSA-372790
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
trans-Golgi Network Vesicle Budding R-HSA-199992
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
GPCR ligand binding R-HSA-500792
TRAF6 mediated NF-kB activation R-HSA-933542
Disease R-HSA-1643685
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Cytokine Signaling in Immune system R-HSA-1280215
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
G alpha (q) signalling events R-HSA-416476
ECM proteoglycans R-HSA-3000178
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Metabolism of proteins R-HSA-392499
Infectious disease R-HSA-5663205
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
Extracellular matrix organization R-HSA-1474244
Platelet degranulation R-HSA-114608
Infectious disease R-HSA-5663205
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Post-translational protein phosphorylation R-HSA-8957275
Metabolism of proteins R-HSA-392499
Vesicle-mediated transport R-HSA-5653656
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Toll-like Receptor Cascades R-HSA-168898
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Lysosome Vesicle Biogenesis R-HSA-432720
Amyloid fiber formation R-HSA-977225
ECM proteoglycans R-HSA-3000178
Interleukin-1 family signaling R-HSA-446652
TRAF6 mediated NF-kB activation R-HSA-933542
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Interleukin-1 signaling R-HSA-9020702
Neurodegenerative Diseases R-HSA-8863678
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by Interleukins R-HSA-449147
G alpha (i) signalling events R-HSA-418594
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Protein localization R-HSA-9609507
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Membrane Trafficking R-HSA-199991
MyD88 dependent cascade initiated on endosome R-HSA-975155
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Inflammasomes R-HSA-622312
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
MyD88 cascade initiated on plasma membrane R-HSA-975871
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
The NLRP3 inflammasome R-HSA-844456
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Disease R-HSA-1643685
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
GPCR ligand binding R-HSA-500792
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
Leishmania infection R-HSA-9658195
Diseases of programmed cell death R-HSA-9645723
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Purinergic signaling in leishmaniasis infection R-HSA-9660826
GPCR downstream signalling R-HSA-388396
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Hemostasis R-HSA-109582
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
trans-Golgi Network Vesicle Budding R-HSA-199992
MyD88-independent TLR4 cascade R-HSA-166166
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Post-translational protein modification R-HSA-597592
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Immune System R-HSA-168256
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
trans-Golgi Network Vesicle Budding R-HSA-199992
Metabolism of proteins R-HSA-392499
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Cell recruitment (pro-inflammatory response) R-HSA-9664424
Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473
Advanced glycosylation endproduct receptor signaling R-HSA-879415
Purinergic signaling in leishmaniasis infection R-HSA-9660826
G alpha (q) signalling events R-HSA-416476
Interleukin-1 signaling R-HSA-9020702
Lysosome Vesicle Biogenesis R-HSA-432720
Platelet degranulation R-HSA-114608
Protein localization R-HSA-9609507
Disease R-HSA-1643685
Platelet activation, signaling and aggregation R-HSA-76002
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MyD88 dependent cascade initiated on endosome R-HSA-975155
Cytokine Signaling in Immune system R-HSA-1280215
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Post-translational protein modification R-HSA-597592
Infectious disease R-HSA-5663205
GPCR downstream signalling R-HSA-388396
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signaling by Interleukins R-HSA-449147
Vesicle-mediated transport R-HSA-5653656
Amyloid fiber formation R-HSA-977225
Innate Immune System R-HSA-168249
MyD88-independent TLR4 cascade R-HSA-166166
Neurodegenerative Diseases R-HSA-8863678
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Leishmania infection R-HSA-9658195
Signaling by GPCR R-HSA-372790
ECM proteoglycans R-HSA-3000178
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll-like Receptor Cascades R-HSA-168898
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane R-HSA-9609523
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8862803
Response to elevated platelet cytosolic Ca2+ R-HSA-76005
Membrane Trafficking R-HSA-199991
The NLRP3 inflammasome R-HSA-844456
MyD88 cascade initiated on plasma membrane R-HSA-975871
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426
Interleukin-1 family signaling R-HSA-446652
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Inflammasomes R-HSA-622312
TRAF6 mediated NF-kB activation R-HSA-933542
Post-translational protein phosphorylation R-HSA-8957275
Defective Intrinsic Pathway for Apoptosis R-HSA-9734009
Extracellular matrix organization R-HSA-1474244
Hemostasis R-HSA-109582
GPCR ligand binding R-HSA-500792
Peptide ligand-binding receptors R-HSA-375276
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Diseases of programmed cell death R-HSA-9645723

Expression Atlas ENSG00000142192
NCBI gene (formerly Entrezgene) 351
GeneCards 620
HGNC Symbol HGNC:620
MIM gene 104760
MIM morbid 605714
UniProtKB Gene Name P05067
WikiGene 351
Gene: OPRL1
Ensembl ID : ENSG00000125510
Description: opioid related nociceptin receptor 1
Gene Synonyms: KOR-3,NOCIR,NOPR,OOR,ORL1,PNOCR
4 APIs:
202 Possible Orthologues:

Peptide ligand-binding receptors R-HSA-375276
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
GPCR ligand binding R-HSA-500792
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Peptide ligand-binding receptors R-HSA-375276
G alpha (i) signalling events R-HSA-418594
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
Peptide ligand-binding receptors R-HSA-375276
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790

Expression Atlas ENSG00000125510
NCBI gene (formerly Entrezgene) 4987
GeneCards 8155
HGNC Symbol HGNC:8155
MIM gene 602548
UniProtKB Gene Name P41146
WikiGene 4987
Gene: MC3R
Ensembl ID : ENSG00000124089
Description: melanocortin 3 receptor
Gene Synonyms: MC3
1 APIs:
139 Possible Orthologues:

Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Peptide ligand-binding receptors R-HSA-375276
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Peptide ligand-binding receptors R-HSA-375276
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
G alpha (s) signalling events R-HSA-418555
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Peptide ligand-binding receptors R-HSA-375276
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076

Expression Atlas ENSG00000124089
NCBI gene (formerly Entrezgene) 4159
GeneCards 6931
HGNC Symbol HGNC:6931
MIM gene 155540
MIM morbid 602025
UniProtKB Gene Name P41968
WikiGene 4159
Gene: GNRHR
Ensembl ID : ENSG00000109163
Description: gonadotropin releasing hormone receptor
Gene Synonyms: GRHR,LHRHR
23 APIs:
242 Possible Orthologues:

Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Hormone ligand-binding receptors R-HSA-375281
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Hormone ligand-binding receptors R-HSA-375281
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
GPCR ligand binding R-HSA-500792
Hormone ligand-binding receptors R-HSA-375281
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
G alpha (q) signalling events R-HSA-416476
Signaling by GPCR R-HSA-372790
Hormone ligand-binding receptors R-HSA-375281
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Hormone ligand-binding receptors R-HSA-375281
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Hormone ligand-binding receptors R-HSA-375281
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Hormone ligand-binding receptors R-HSA-375281
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Hormone ligand-binding receptors R-HSA-375281
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (q) signalling events R-HSA-416476
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Hormone ligand-binding receptors R-HSA-375281
G alpha (q) signalling events R-HSA-416476
GPCR ligand binding R-HSA-500792
Hormone ligand-binding receptors R-HSA-375281
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (q) signalling events R-HSA-416476
Hormone ligand-binding receptors R-HSA-375281
Class A/1 (Rhodopsin-like receptors) R-HSA-373076

Expression Atlas ENSG00000109163
NCBI gene (formerly Entrezgene) 2798
GeneCards 4421
HGNC Symbol HGNC:4421
MIM gene 138850
MIM morbid 146110
UniProtKB Gene Name P30968
WikiGene 2798
Gene: HCRTR1
Ensembl ID : ENSG00000121764
Description: hypocretin receptor 1
Gene Synonyms: ORXR1,OX1R,OXR1
2 APIs:
95 Possible Orthologues:

Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
G alpha (q) signalling events R-HSA-416476
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
Peptide ligand-binding receptors R-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
G alpha (q) signalling events R-HSA-416476
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
Signal Transduction R-HSA-162582
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
G alpha (q) signalling events R-HSA-416476
G alpha (q) signalling events R-HSA-416476
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Peptide ligand-binding receptors R-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
GPCR ligand binding R-HSA-500792
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Peptide ligand-binding receptors R-HSA-375276
GPCR ligand binding R-HSA-500792
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (q) signalling events R-HSA-416476
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
G alpha (q) signalling events R-HSA-416476
Signal Transduction R-HSA-162582
Peptide ligand-binding receptors R-HSA-375276
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Peptide ligand-binding receptors R-HSA-375276
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Peptide ligand-binding receptors R-HSA-375276
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (q) signalling events R-HSA-416476

Expression Atlas ENSG00000121764
NCBI gene (formerly Entrezgene) 3061
GeneCards 4848
HGNC Symbol HGNC:4848
MIM gene 602392
UniProtKB Gene Name O43613
WikiGene 3061
Gene: CRHR1
Ensembl ID : ENSG00000120088
Description: corticotropin releasing hormone receptor 1
Gene Synonyms: CRF-R,CRF1,CRHR
5 APIs:
208 Possible Orthologues:

Class B/2 (Secretin family receptors) R-HSA-373080
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
Class B/2 (Secretin family receptors) R-HSA-373080
Class B/2 (Secretin family receptors) R-HSA-373080
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Class B/2 (Secretin family receptors) R-HSA-373080
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Class B/2 (Secretin family receptors) R-HSA-373080
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Class B/2 (Secretin family receptors) R-HSA-373080
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Class B/2 (Secretin family receptors) R-HSA-373080
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Class B/2 (Secretin family receptors) R-HSA-373080
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Class B/2 (Secretin family receptors) R-HSA-373080
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
Class B/2 (Secretin family receptors) R-HSA-373080
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Class B/2 (Secretin family receptors) R-HSA-373080
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396

Expression Atlas ENSG00000120088
NCBI gene (formerly Entrezgene) 1394
GeneCards 2357
HGNC Symbol HGNC:2357
MIM gene 122561
UniProtKB Gene Name P34998
WikiGene 1394
Gene: HTR7
Ensembl ID : ENSG00000148680
Description: 5-hydroxytryptamine receptor 7
Gene Synonyms: 5-HT7
5 APIs:
220 Possible Orthologues:

Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Serotonin receptors R-HSA-390666
RHOBTB3 ATPase cycle R-HSA-9706019
Amine ligand-binding receptors R-HSA-375280
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Serotonin receptors R-HSA-390666
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
RHOBTB3 ATPase cycle R-HSA-9706019
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Amine ligand-binding receptors R-HSA-375280
GPCR downstream signalling R-HSA-388396
RHOBTB3 ATPase cycle R-HSA-9706019
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Serotonin receptors R-HSA-390666
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
RHOBTB3 ATPase cycle R-HSA-9706019
GPCR downstream signalling R-HSA-388396
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Serotonin receptors R-HSA-390666
Signal Transduction R-HSA-162582
Amine ligand-binding receptors R-HSA-375280
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (s) signalling events R-HSA-418555
Serotonin receptors R-HSA-390666
Signaling by GPCR R-HSA-372790
RHOBTB3 ATPase cycle R-HSA-9706019
Amine ligand-binding receptors R-HSA-375280
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
RHOBTB3 ATPase cycle R-HSA-9706019
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
GPCR ligand binding R-HSA-500792
Serotonin receptors R-HSA-390666
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOBTB3 ATPase cycle R-HSA-9706019
GPCR downstream signalling R-HSA-388396
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
GPCR ligand binding R-HSA-500792
Serotonin receptors R-HSA-390666
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (s) signalling events R-HSA-418555
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
RHOBTB3 ATPase cycle R-HSA-9706019
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Serotonin receptors R-HSA-390666
Signal Transduction R-HSA-162582
Amine ligand-binding receptors R-HSA-375280
Signaling by GPCR R-HSA-372790
RHOBTB3 ATPase cycle R-HSA-9706019
Serotonin receptors R-HSA-390666
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
GPCR downstream signalling R-HSA-388396
Amine ligand-binding receptors R-HSA-375280
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
RHOBTB3 ATPase cycle R-HSA-9706019
G alpha (s) signalling events R-HSA-418555
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Amine ligand-binding receptors R-HSA-375280
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Serotonin receptors R-HSA-390666
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by GPCR R-HSA-372790
RHOBTB3 ATPase cycle R-HSA-9706019
GPCR ligand binding R-HSA-500792
Serotonin receptors R-HSA-390666

Expression Atlas ENSG00000148680
NCBI gene (formerly Entrezgene) 3363
GeneCards 5302
HGNC Symbol HGNC:5302
MIM gene 182137
UniProtKB Gene Name P34969
WikiGene 3363
Gene: DRD1
Ensembl ID : ENSG00000184845
Description: dopamine receptor D1
Gene Synonyms:
9 APIs:
262 Possible Orthologues:

Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Dopamine receptors R-HSA-390651
GPCR ligand binding R-HSA-500792
Amine ligand-binding receptors R-HSA-375280
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR ligand binding R-HSA-500792
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Amine ligand-binding receptors R-HSA-375280
G alpha (s) signalling events R-HSA-418555
Dopamine receptors R-HSA-390651
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Dopamine receptors R-HSA-390651
GPCR downstream signalling R-HSA-388396
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Amine ligand-binding receptors R-HSA-375280
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Dopamine receptors R-HSA-390651
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
GPCR ligand binding R-HSA-500792
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
Dopamine receptors R-HSA-390651
Signaling by GPCR R-HSA-372790
Amine ligand-binding receptors R-HSA-375280
Dopamine receptors R-HSA-390651
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Amine ligand-binding receptors R-HSA-375280
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Dopamine receptors R-HSA-390651
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
GPCR ligand binding R-HSA-500792
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Amine ligand-binding receptors R-HSA-375280
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Dopamine receptors R-HSA-390651
GPCR downstream signalling R-HSA-388396
Dopamine receptors R-HSA-390651
GPCR ligand binding R-HSA-500792
Signal Transduction R-HSA-162582
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
G alpha (s) signalling events R-HSA-418555
Amine ligand-binding receptors R-HSA-375280
Signaling by GPCR R-HSA-372790
Class A/1 (Rhodopsin-like receptors) R-HSA-373076
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Dopamine receptors R-HSA-390651
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
Amine ligand-binding receptors R-HSA-375280
GPCR ligand binding R-HSA-500792

Expression Atlas ENSG00000184845
NCBI gene (formerly Entrezgene) 1812
GeneCards 3020
HGNC Symbol HGNC:3020
MIM gene 126449
UniProtKB Gene Name P21728
WikiGene 1812