Gene: EGFR
Ensembl ID : ENSG00000146648
Description: epidermal growth factor receptor
Gene Synonyms: ERBB,ERBB1,ERRP
73 APIs:
286 Possible Orthologues:

Disease R-HSA-1643685
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
Downregulation of ERBB2 signaling R-HSA-8863795
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
Signaling by ERBB2 ECD mutants R-HSA-9665348
L1CAM interactions R-HSA-373760
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
HCMV Early Events R-HSA-9609690
GRB2 events in EGFR signaling R-HSA-179812
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PIP3 activates AKT signaling R-HSA-1257604
Membrane Trafficking R-HSA-199991
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
PI3K events in ERBB2 signaling R-HSA-1963642
Gene expression (Transcription) R-HSA-74160
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by Nuclear Receptors R-HSA-9006931
ESR-mediated signaling R-HSA-8939211
Developmental Biology R-HSA-1266738
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Intracellular signaling by second messengers R-HSA-9006925
Signal transduction by L1 R-HSA-445144
Extra-nuclear estrogen signaling R-HSA-9009391
Nervous system development R-HSA-9675108
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Signaling by PTK6 R-HSA-8848021
EGFR Transactivation by Gastrin R-HSA-2179392
G alpha (q) signalling events R-HSA-416476
Axon guidance R-HSA-422475
HCMV Infection R-HSA-9609646
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by EGFRvIII in Cancer R-HSA-5637812
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by GPCR R-HSA-372790
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Signal Transduction R-HSA-162582
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by ERBB2 in Cancer R-HSA-1227990
ERBB2 Regulates Cell Motility R-HSA-6785631
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by ERBB4 R-HSA-1236394
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR in Cancer R-HSA-1643713
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 KD Mutants R-HSA-9664565
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by NOTCH3 R-HSA-9012852
PTK6 promotes HIF1A stabilization R-HSA-8857538
GPCR downstream signalling R-HSA-388396
Infectious disease R-HSA-5663205
SHC1 events in ERBB2 signaling R-HSA-1250196
SHC1 events in EGFR signaling R-HSA-180336
Vesicle-mediated transport R-HSA-5653656
GAB1 signalosome R-HSA-180292
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K/AKT Signaling in Cancer R-HSA-2219528
PLCG1 events in ERBB2 signaling R-HSA-1251932
EGFR downregulation R-HSA-182971
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB2 R-HSA-1227986
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by EGFR R-HSA-177929
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by NOTCH R-HSA-157118
Generic Transcription Pathway R-HSA-212436
Negative regulation of the PI3K/AKT network R-HSA-199418
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
SHC1 events in ERBB2 signaling R-HSA-1250196
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by ERBB2 R-HSA-1227986
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by PTK6 R-HSA-8848021
GPCR downstream signalling R-HSA-388396
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
PI3K/AKT Signaling in Cancer R-HSA-2219528
Developmental Biology R-HSA-1266738
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by NOTCH R-HSA-157118
PIP3 activates AKT signaling R-HSA-1257604
Signal transduction by L1 R-HSA-445144
Membrane Trafficking R-HSA-199991
Signaling by ERBB4 R-HSA-1236394
Signaling by EGFRvIII in Cancer R-HSA-5637812
Vesicle-mediated transport R-HSA-5653656
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
L1CAM interactions R-HSA-373760
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by Nuclear Receptors R-HSA-9006931
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
ESR-mediated signaling R-HSA-8939211
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
HCMV Infection R-HSA-9609646
Signaling by ERBB2 in Cancer R-HSA-1227990
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR R-HSA-177929
Signaling by GPCR R-HSA-372790
Axon guidance R-HSA-422475
GRB2 events in ERBB2 signaling R-HSA-1963640
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Infectious disease R-HSA-5663205
Signaling by NOTCH3 R-HSA-9012852
G alpha (q) signalling events R-HSA-416476
MAPK1/MAPK3 signaling R-HSA-5684996
Clathrin-mediated endocytosis R-HSA-8856828
Constitutive Signaling by EGFRvIII R-HSA-5637810
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
EGFR downregulation R-HSA-182971
GAB1 signalosome R-HSA-180292
GRB2 events in EGFR signaling R-HSA-179812
Downregulation of ERBB2 signaling R-HSA-8863795
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Nervous system development R-HSA-9675108
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
RAF/MAP kinase cascade R-HSA-5673001
MAPK family signaling cascades R-HSA-5683057
Extra-nuclear estrogen signaling R-HSA-9009391
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ERBB2 ECD mutants R-HSA-9665348
PTK6 promotes HIF1A stabilization R-HSA-8857538
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
HCMV Early Events R-HSA-9609690
SHC1 events in EGFR signaling R-HSA-180336
PLCG1 events in ERBB2 signaling R-HSA-1251932
Signaling by ERBB2 KD Mutants R-HSA-9664565
Constitutive Signaling by EGFRvIII R-HSA-5637810
Infectious disease R-HSA-5663205
Signaling by Nuclear Receptors R-HSA-9006931
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
SHC1 events in ERBB2 signaling R-HSA-1250196
Signal Transduction R-HSA-162582
PIP3 activates AKT signaling R-HSA-1257604
Nervous system development R-HSA-9675108
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PLCG1 events in ERBB2 signaling R-HSA-1251932
L1CAM interactions R-HSA-373760
EGFR downregulation R-HSA-182971
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by EGFR R-HSA-177929
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by EGFRvIII in Cancer R-HSA-5637812
Axon guidance R-HSA-422475
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
GRB2 events in EGFR signaling R-HSA-179812
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
ESR-mediated signaling R-HSA-8939211
RNA Polymerase II Transcription R-HSA-73857
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by EGFR in Cancer R-HSA-1643713
Negative regulation of the PI3K/AKT network R-HSA-199418
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by ERBB4 R-HSA-1236394
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Downregulation of ERBB2 signaling R-HSA-8863795
Vesicle-mediated transport R-HSA-5653656
GPCR downstream signalling R-HSA-388396
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
Signaling by PTK6 R-HSA-8848021
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
ERBB2 Regulates Cell Motility R-HSA-6785631
Generic Transcription Pathway R-HSA-212436
HCMV Early Events R-HSA-9609690
Signaling by NOTCH R-HSA-157118
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Developmental Biology R-HSA-1266738
Signal transduction by L1 R-HSA-445144
GRB2 events in ERBB2 signaling R-HSA-1963640
MAPK family signaling cascades R-HSA-5683057
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by GPCR R-HSA-372790
G alpha (q) signalling events R-HSA-416476
RAF/MAP kinase cascade R-HSA-5673001
Signaling by ERBB2 ECD mutants R-HSA-9665348
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI3K events in ERBB2 signaling R-HSA-1963642
Gene expression (Transcription) R-HSA-74160
Membrane Trafficking R-HSA-199991
GAB1 signalosome R-HSA-180292
SHC1 events in EGFR signaling R-HSA-180336
Signaling by ERBB2 R-HSA-1227986
EGFR interacts with phospholipase C-gamma R-HSA-212718
Extra-nuclear estrogen signaling R-HSA-9009391
HCMV Infection R-HSA-9609646
MAPK1/MAPK3 signaling R-HSA-5684996
PTK6 promotes HIF1A stabilization R-HSA-8857538
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by NOTCH3 R-HSA-9012852
Developmental Biology R-HSA-1266738
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by EGFR in Cancer R-HSA-1643713
Constitutive Signaling by EGFRvIII R-HSA-5637810
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Infectious disease R-HSA-5663205
Signaling by GPCR R-HSA-372790
Signaling by ERBB2 KD Mutants R-HSA-9664565
RNA Polymerase II Transcription R-HSA-73857
Nervous system development R-HSA-9675108
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by EGFRvIII in Cancer R-HSA-5637812
G alpha (q) signalling events R-HSA-416476
Axon guidance R-HSA-422475
Vesicle-mediated transport R-HSA-5653656
HCMV Early Events R-HSA-9609690
Signaling by ERBB4 R-HSA-1236394
Signaling by EGFR R-HSA-177929
L1CAM interactions R-HSA-373760
GRB2 events in EGFR signaling R-HSA-179812
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signal Transduction R-HSA-162582
MAPK family signaling cascades R-HSA-5683057
Signaling by NOTCH3 R-HSA-9012852
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
GAB1 signalosome R-HSA-180292
SHC1 events in EGFR signaling R-HSA-180336
Signaling by PTK6 R-HSA-8848021
PLCG1 events in ERBB2 signaling R-HSA-1251932
PTK6 promotes HIF1A stabilization R-HSA-8857538
PIP3 activates AKT signaling R-HSA-1257604
Gene expression (Transcription) R-HSA-74160
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
RAF/MAP kinase cascade R-HSA-5673001
Signaling by NOTCH R-HSA-157118
Signal transduction by L1 R-HSA-445144
SHC1 events in ERBB2 signaling R-HSA-1250196
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by ERBB2 ECD mutants R-HSA-9665348
Intracellular signaling by second messengers R-HSA-9006925
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Membrane Trafficking R-HSA-199991
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
ERBB2 Regulates Cell Motility R-HSA-6785631
Generic Transcription Pathway R-HSA-212436
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by ERBB2 R-HSA-1227986
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Extra-nuclear estrogen signaling R-HSA-9009391
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Downregulation of ERBB2 signaling R-HSA-8863795
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EGFR downregulation R-HSA-182971
PI3K/AKT Signaling in Cancer R-HSA-2219528
PI3K events in ERBB2 signaling R-HSA-1963642
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by Nuclear Receptors R-HSA-9006931
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
GPCR downstream signalling R-HSA-388396
ESR-mediated signaling R-HSA-8939211
EGFR Transactivation by Gastrin R-HSA-2179392
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
HCMV Infection R-HSA-9609646
Signaling by ERBB2 in Cancer R-HSA-1227990
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Vesicle-mediated transport R-HSA-5653656
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
RAF/MAP kinase cascade R-HSA-5673001
Nervous system development R-HSA-9675108
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SHC1 events in EGFR signaling R-HSA-180336
ERBB2 Regulates Cell Motility R-HSA-6785631
RNA Polymerase II Transcription R-HSA-73857
PI3K/AKT Signaling in Cancer R-HSA-2219528
Generic Transcription Pathway R-HSA-212436
Signaling by ERBB2 ECD mutants R-HSA-9665348
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Signal Transduction R-HSA-162582
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
PLCG1 events in ERBB2 signaling R-HSA-1251932
GAB1 signalosome R-HSA-180292
HCMV Early Events R-HSA-9609690
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by Nuclear Receptors R-HSA-9006931
SHC1 events in ERBB2 signaling R-HSA-1250196
G alpha (q) signalling events R-HSA-416476
Signaling by PTK6 R-HSA-8848021
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signal transduction by L1 R-HSA-445144
Signaling by GPCR R-HSA-372790
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
PTK6 promotes HIF1A stabilization R-HSA-8857538
L1CAM interactions R-HSA-373760
Signaling by NOTCH R-HSA-157118
PI3K events in ERBB2 signaling R-HSA-1963642
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Infectious disease R-HSA-5663205
Signaling by EGFR in Cancer R-HSA-1643713
Disease R-HSA-1643685
ESR-mediated signaling R-HSA-8939211
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by EGFR R-HSA-177929
EGFR downregulation R-HSA-182971
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Developmental Biology R-HSA-1266738
EGFR Transactivation by Gastrin R-HSA-2179392
Intracellular signaling by second messengers R-HSA-9006925
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB2 KD Mutants R-HSA-9664565
Membrane Trafficking R-HSA-199991
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Extra-nuclear estrogen signaling R-HSA-9009391
MAPK family signaling cascades R-HSA-5683057
Negative regulation of the PI3K/AKT network R-HSA-199418
GRB2 events in EGFR signaling R-HSA-179812
Signaling by ERBB4 R-HSA-1236394
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by EGFRvIII in Cancer R-HSA-5637812
Gene expression (Transcription) R-HSA-74160
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB2 R-HSA-1227986
EGFR interacts with phospholipase C-gamma R-HSA-212718
HCMV Infection R-HSA-9609646
GPCR downstream signalling R-HSA-388396
Constitutive Signaling by EGFRvIII R-HSA-5637810
Axon guidance R-HSA-422475
EGFR interacts with phospholipase C-gamma R-HSA-212718
G alpha (q) signalling events R-HSA-416476
Signaling by ERBB4 R-HSA-1236394
SHC1 events in ERBB2 signaling R-HSA-1250196
Gene expression (Transcription) R-HSA-74160
Nervous system development R-HSA-9675108
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by Nuclear Receptors R-HSA-9006931
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Signaling by ERBB2 ECD mutants R-HSA-9665348
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by EGFR R-HSA-177929
Signaling by ERBB2 KD Mutants R-HSA-9664565
RAF/MAP kinase cascade R-HSA-5673001
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
GRB2 events in ERBB2 signaling R-HSA-1963640
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by ERBB2 R-HSA-1227986
ERBB2 Activates PTK6 Signaling R-HSA-8847993
PLCG1 events in ERBB2 signaling R-HSA-1251932
HCMV Early Events R-HSA-9609690
Negative regulation of the PI3K/AKT network R-HSA-199418
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PTK6 promotes HIF1A stabilization R-HSA-8857538
Signaling by ERBB2 in Cancer R-HSA-1227990
Signal transduction by L1 R-HSA-445144
ERBB2 Regulates Cell Motility R-HSA-6785631
MAPK family signaling cascades R-HSA-5683057
Intracellular signaling by second messengers R-HSA-9006925
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
GRB2 events in EGFR signaling R-HSA-179812
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Generic Transcription Pathway R-HSA-212436
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Axon guidance R-HSA-422475
PIP3 activates AKT signaling R-HSA-1257604
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
ESR-mediated signaling R-HSA-8939211
Signaling by NOTCH R-HSA-157118
Signaling by EGFRvIII in Cancer R-HSA-5637812
Developmental Biology R-HSA-1266738
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Clathrin-mediated endocytosis R-HSA-8856828
Signaling by GPCR R-HSA-372790
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by PTK6 R-HSA-8848021
PI3K events in ERBB2 signaling R-HSA-1963642
Infectious disease R-HSA-5663205
L1CAM interactions R-HSA-373760
EGFR downregulation R-HSA-182971
EGFR Transactivation by Gastrin R-HSA-2179392
SHC1 events in EGFR signaling R-HSA-180336
Membrane Trafficking R-HSA-199991
Vesicle-mediated transport R-HSA-5653656
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Constitutive Signaling by EGFRvIII R-HSA-5637810
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Signaling by NOTCH3 R-HSA-9012852
Downregulation of ERBB2 signaling R-HSA-8863795
GAB1 signalosome R-HSA-180292
GPCR downstream signalling R-HSA-388396
HCMV Infection R-HSA-9609646
Signaling by Nuclear Receptors R-HSA-9006931
MAPK family signaling cascades R-HSA-5683057
ESR-mediated signaling R-HSA-8939211
Intracellular signaling by second messengers R-HSA-9006925
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 R-HSA-1227986
Signaling by NOTCH3 R-HSA-9012852
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by EGFR in Cancer R-HSA-1643713
HCMV Infection R-HSA-9609646
Membrane Trafficking R-HSA-199991
ERBB2 Regulates Cell Motility R-HSA-6785631
PI3K/AKT Signaling in Cancer R-HSA-2219528
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
SHC1 events in ERBB2 signaling R-HSA-1250196
PTK6 promotes HIF1A stabilization R-HSA-8857538
Signaling by NOTCH R-HSA-157118
GRB2 events in EGFR signaling R-HSA-179812
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Developmental Biology R-HSA-1266738
RAF/MAP kinase cascade R-HSA-5673001
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Vesicle-mediated transport R-HSA-5653656
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by ERBB2 in Cancer R-HSA-1227990
Constitutive Signaling by EGFRvIII R-HSA-5637810
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Infectious disease R-HSA-5663205
Nervous system development R-HSA-9675108
G alpha (q) signalling events R-HSA-416476
Generic Transcription Pathway R-HSA-212436
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Signal Transduction R-HSA-162582
L1CAM interactions R-HSA-373760
EGFR downregulation R-HSA-182971
Extra-nuclear estrogen signaling R-HSA-9009391
PI3K events in ERBB2 signaling R-HSA-1963642
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by EGFRvIII in Cancer R-HSA-5637812
Disease R-HSA-1643685
SHC1 events in EGFR signaling R-HSA-180336
Signaling by GPCR R-HSA-372790
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
EGFR interacts with phospholipase C-gamma R-HSA-212718
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by PTK6 R-HSA-8848021
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
GRB2 events in ERBB2 signaling R-HSA-1963640
Clathrin-mediated endocytosis R-HSA-8856828
GAB1 signalosome R-HSA-180292
Downregulation of ERBB2 signaling R-HSA-8863795
PLCG1 events in ERBB2 signaling R-HSA-1251932
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by EGFR R-HSA-177929
GPCR downstream signalling R-HSA-388396
EGFR Transactivation by Gastrin R-HSA-2179392
PIP3 activates AKT signaling R-HSA-1257604
Gene expression (Transcription) R-HSA-74160
Axon guidance R-HSA-422475
Signal transduction by L1 R-HSA-445144
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
HCMV Early Events R-HSA-9609690
Signaling by ERBB4 R-HSA-1236394
Negative regulation of the PI3K/AKT network R-HSA-199418
Downregulation of ERBB2 signaling R-HSA-8863795
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PI3K events in ERBB2 signaling R-HSA-1963642
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by EGFR R-HSA-177929
PTK6 promotes HIF1A stabilization R-HSA-8857538
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Developmental Biology R-HSA-1266738
Infectious disease R-HSA-5663205
GAB1 signalosome R-HSA-180292
RNA Polymerase II Transcription R-HSA-73857
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by ERBB4 R-HSA-1236394
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by GPCR R-HSA-372790
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
GPCR downstream signalling R-HSA-388396
Signaling by EGFR in Cancer R-HSA-1643713
PIP3 activates AKT signaling R-HSA-1257604
Gene expression (Transcription) R-HSA-74160
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Signaling by NOTCH3 R-HSA-9012852
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by ERBB2 in Cancer R-HSA-1227990
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal Transduction R-HSA-162582
Signaling by ERBB2 R-HSA-1227986
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
Extra-nuclear estrogen signaling R-HSA-9009391
Generic Transcription Pathway R-HSA-212436
L1CAM interactions R-HSA-373760
Signaling by ERBB2 KD Mutants R-HSA-9664565
Nervous system development R-HSA-9675108
MAPK1/MAPK3 signaling R-HSA-5684996
EGFR downregulation R-HSA-182971
G alpha (q) signalling events R-HSA-416476
Signal transduction by L1 R-HSA-445144
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
GRB2 events in ERBB2 signaling R-HSA-1963640
Intracellular signaling by second messengers R-HSA-9006925
EGFR interacts with phospholipase C-gamma R-HSA-212718
RAF/MAP kinase cascade R-HSA-5673001
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
ERBB2 Regulates Cell Motility R-HSA-6785631
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PLCG1 events in ERBB2 signaling R-HSA-1251932
GRB2 events in EGFR signaling R-HSA-179812
EGFR Transactivation by Gastrin R-HSA-2179392
HCMV Early Events R-HSA-9609690
SHC1 events in EGFR signaling R-HSA-180336
Signaling by NOTCH R-HSA-157118
MAPK family signaling cascades R-HSA-5683057
Signaling by PTK6 R-HSA-8848021
Clathrin-mediated endocytosis R-HSA-8856828
Disease R-HSA-1643685
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Membrane Trafficking R-HSA-199991
Axon guidance R-HSA-422475
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Vesicle-mediated transport R-HSA-5653656
HCMV Infection R-HSA-9609646
ESR-mediated signaling R-HSA-8939211
Intracellular signaling by second messengers R-HSA-9006925
Nervous system development R-HSA-9675108
EGFR Transactivation by Gastrin R-HSA-2179392
PLCG1 events in ERBB2 signaling R-HSA-1251932
Signal transduction by L1 R-HSA-445144
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
GPCR downstream signalling R-HSA-388396
HCMV Infection R-HSA-9609646
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
MAPK1/MAPK3 signaling R-HSA-5684996
PIP3 activates AKT signaling R-HSA-1257604
Signaling by PTK6 R-HSA-8848021
EGFR interacts with phospholipase C-gamma R-HSA-212718
HCMV Early Events R-HSA-9609690
EGFR downregulation R-HSA-182971
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by ERBB4 R-HSA-1236394
Axon guidance R-HSA-422475
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
PTK6 promotes HIF1A stabilization R-HSA-8857538
GRB2 events in EGFR signaling R-HSA-179812
MAPK family signaling cascades R-HSA-5683057
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
RNA Polymerase II Transcription R-HSA-73857
Clathrin-mediated endocytosis R-HSA-8856828
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Downregulation of ERBB2 signaling R-HSA-8863795
Signaling by EGFR R-HSA-177929
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Nuclear Receptors R-HSA-9006931
Generic Transcription Pathway R-HSA-212436
SHC1 events in EGFR signaling R-HSA-180336
Vesicle-mediated transport R-HSA-5653656
Signaling by EGFR in Cancer R-HSA-1643713
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by NOTCH R-HSA-157118
PI3K/AKT Signaling in Cancer R-HSA-2219528
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by ERBB2 in Cancer R-HSA-1227990
ERBB2 Regulates Cell Motility R-HSA-6785631
ESR-mediated signaling R-HSA-8939211
L1CAM interactions R-HSA-373760
RAF/MAP kinase cascade R-HSA-5673001
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Signaling by NOTCH3 R-HSA-9012852
Signal Transduction R-HSA-162582
G alpha (q) signalling events R-HSA-416476
GAB1 signalosome R-HSA-180292
Signaling by GPCR R-HSA-372790
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
PI3K events in ERBB2 signaling R-HSA-1963642
Signaling by ERBB2 R-HSA-1227986
Signaling by ERBB2 KD Mutants R-HSA-9664565
Disease R-HSA-1643685
SHC1 events in ERBB2 signaling R-HSA-1250196
Gene expression (Transcription) R-HSA-74160
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Membrane Trafficking R-HSA-199991
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by EGFRvIII in Cancer R-HSA-5637812
Extra-nuclear estrogen signaling R-HSA-9009391
Constitutive Signaling by EGFRvIII R-HSA-5637810
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Infectious disease R-HSA-5663205
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by EGFR in Cancer R-HSA-1643713
Intracellular signaling by second messengers R-HSA-9006925
Downregulation of ERBB2 signaling R-HSA-8863795
PI3K/AKT Signaling in Cancer R-HSA-2219528
Signaling by NOTCH R-HSA-157118
EGFR downregulation R-HSA-182971
GRB2 events in ERBB2 signaling R-HSA-1963640
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by ERBB2 in Cancer R-HSA-1227990
Infectious disease R-HSA-5663205
Signaling by ERBB2 R-HSA-1227986
Generic Transcription Pathway R-HSA-212436
Clathrin-mediated endocytosis R-HSA-8856828
RNA Polymerase II Transcription R-HSA-73857
Signaling by ERBB4 R-HSA-1236394
PTK6 promotes HIF1A stabilization R-HSA-8857538
SHC1 events in ERBB2 signaling R-HSA-1250196
Disease R-HSA-1643685
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
ERBB2 Regulates Cell Motility R-HSA-6785631
Gene expression (Transcription) R-HSA-74160
Vesicle-mediated transport R-HSA-5653656
Axon guidance R-HSA-422475
Signaling by PTK6 R-HSA-8848021
HCMV Infection R-HSA-9609646
MAPK family signaling cascades R-HSA-5683057
NOTCH3 Activation and Transmission of Signal to the Nucleus R-HSA-9013507
Cargo recognition for clathrin-mediated endocytosis R-HSA-8856825
HCMV Early Events R-HSA-9609690
RAF/MAP kinase cascade R-HSA-5673001
EGFR interacts with phospholipase C-gamma R-HSA-212718
Membrane Trafficking R-HSA-199991
Constitutive Signaling by EGFRvIII R-HSA-5637810
PI3K events in ERBB2 signaling R-HSA-1963642
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
GAB1 signalosome R-HSA-180292
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signal transduction by L1 R-HSA-445144
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by GPCR R-HSA-372790
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8864260
GPCR downstream signalling R-HSA-388396
Signaling by NOTCH3 R-HSA-9012852
Signal Transduction R-HSA-162582
EGFR Transactivation by Gastrin R-HSA-2179392
Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303
L1CAM interactions R-HSA-373760
Signaling by EGFR R-HSA-177929
G alpha (q) signalling events R-HSA-416476
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9634638
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Negative regulation of the PI3K/AKT network R-HSA-199418
PLCG1 events in ERBB2 signaling R-HSA-1251932
PIP3 activates AKT signaling R-HSA-1257604
Nervous system development R-HSA-9675108
ERBB2 Activates PTK6 Signaling R-HSA-8847993
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
GRB2 events in EGFR signaling R-HSA-179812
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866910
ESR-mediated signaling R-HSA-8939211
Developmental Biology R-HSA-1266738
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
SHC1 events in EGFR signaling R-HSA-180336

Expression Atlas ENSG00000146648
LRG display in Ensembl gene LRG_304
NCBI gene (formerly Entrezgene) 1956
GeneCards 3236
HGNC Symbol HGNC:3236
MIM gene 131550
MIM morbid 616069
UniProtKB Gene Name Q504U8
WikiGene 1956
Gene: BRAF
Ensembl ID : ENSG00000157764
Description: B-Raf proto-oncogene, serine/threonine kinase
Gene Synonyms: BRAF-1,BRAF1
14 APIs:
211 Possible Orthologues:

Oncogenic MAPK signaling R-HSA-6802957
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF activation R-HSA-5673000
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by FGFR4 R-HSA-5654743
Negative feedback regulation of MAPK pathway R-HSA-5674499
Disease R-HSA-1643685
Negative regulation of MAPK pathway R-HSA-5675221
MAPK family signaling cascades R-HSA-5683057
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by NTRK1 (TRKA) R-HSA-187037
Negative regulation of FGFR1 signaling R-HSA-5654726
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
ARMS-mediated activation R-HSA-170984
Signaling downstream of RAS mutants R-HSA-9649948
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR2 signaling R-HSA-5654727
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by FGFR1 R-HSA-5654736
Frs2-mediated activation R-HSA-170968
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by FGFR R-HSA-190236
Signalling to ERKs R-HSA-187687
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAP2K and MAPK activation R-HSA-5674135
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR2 R-HSA-5654738
Signaling by NTRKs R-HSA-166520
Signal Transduction R-HSA-162582
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
Prolonged ERK activation events R-HSA-169893
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR2 R-HSA-5654738
Signaling by RAS mutants R-HSA-6802949
RAF activation R-HSA-5673000
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by FGFR1 R-HSA-5654736
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAF1 mutants R-HSA-9656223
Negative feedback regulation of MAPK pathway R-HSA-5674499
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by NTRK1 (TRKA) R-HSA-187037
Frs2-mediated activation R-HSA-170968
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signalling to p38 via RIT and RIN R-HSA-187706
Signalling to ERKs R-HSA-187687
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by FGFR4 R-HSA-5654743
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by FGFR R-HSA-190236
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR4 signaling R-HSA-5654733
ARMS-mediated activation R-HSA-170984
Negative regulation of FGFR1 signaling R-HSA-5654726
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAP2K and MAPK activation R-HSA-5674135
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling downstream of RAS mutants R-HSA-9649948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
ARMS-mediated activation R-HSA-170984
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR R-HSA-190236
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
RAF activation R-HSA-5673000
Signaling by RAS mutants R-HSA-6802949
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by FGFR4 R-HSA-5654743
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by FGFR3 R-HSA-5654741
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAPK family signaling cascades R-HSA-5683057
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by NTRK1 (TRKA) R-HSA-187037
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR1 R-HSA-5654736
Signaling by NTRKs R-HSA-166520
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative regulation of FGFR4 signaling R-HSA-5654733
Prolonged ERK activation events R-HSA-169893
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR2 R-HSA-5654738
Oncogenic MAPK signaling R-HSA-6802957
Signalling to p38 via RIT and RIN R-HSA-187706
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
Negative regulation of FGFR2 signaling R-HSA-5654727
RAF activation R-HSA-5673000
Signaling by FGFR2 R-HSA-5654738
Signaling by FGFR4 R-HSA-5654743
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signalling to ERKs R-HSA-187687
ARMS-mediated activation R-HSA-170984
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAF1 mutants R-HSA-9656223
Signaling by NTRKs R-HSA-166520
Signaling by FGFR3 R-HSA-5654741
Oncogenic MAPK signaling R-HSA-6802957
MAPK family signaling cascades R-HSA-5683057
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative regulation of FGFR2 signaling R-HSA-5654727
Frs2-mediated activation R-HSA-170968
Disease R-HSA-1643685
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Spry regulation of FGF signaling R-HSA-1295596
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by FGFR1 R-HSA-5654736
Signal Transduction R-HSA-162582
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling downstream of RAS mutants R-HSA-9649948
Prolonged ERK activation events R-HSA-169893
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by RAS mutants R-HSA-6802949
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR2 signaling R-HSA-5654727
Negative regulation of FGFR3 signaling R-HSA-5654732
RAF/MAP kinase cascade R-HSA-5673001
Negative feedback regulation of MAPK pathway R-HSA-5674499
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
ARMS-mediated activation R-HSA-170984
RAF activation R-HSA-5673000
Signaling by FGFR1 R-HSA-5654736
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Spry regulation of FGF signaling R-HSA-1295596
Prolonged ERK activation events R-HSA-169893
Signalling to ERKs R-HSA-187687
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAS mutants R-HSA-6802949
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by NTRKs R-HSA-166520
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
Signaling downstream of RAS mutants R-HSA-9649948
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR R-HSA-190236
Signaling by NTRK1 (TRKA) R-HSA-187037
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Oncogenic MAPK signaling R-HSA-6802957
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
Signaling by FGFR3 R-HSA-5654741
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by MRAS-complex mutants R-HSA-9660537
Negative regulation of FGFR4 signaling R-HSA-5654733
RAF/MAP kinase cascade R-HSA-5673001
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
Signaling by FGFR1 R-HSA-5654736
Signaling downstream of RAS mutants R-HSA-9649948
Spry regulation of FGF signaling R-HSA-1295596
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR4 signaling R-HSA-5654733
ARMS-mediated activation R-HSA-170984
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by RAS mutants R-HSA-6802949
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Disease R-HSA-1643685
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
MAP2K and MAPK activation R-HSA-5674135
Signalling to p38 via RIT and RIN R-HSA-187706
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR3 R-HSA-5654741
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR R-HSA-190236
Signaling by NTRK1 (TRKA) R-HSA-187037
Negative regulation of FGFR3 signaling R-HSA-5654732
Negative feedback regulation of MAPK pathway R-HSA-5674499
Frs2-mediated activation R-HSA-170968
Signaling by FGFR4 R-HSA-5654743
Signaling by MRAS-complex mutants R-HSA-9660537
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
RAF activation R-HSA-5673000
Signaling by RAF1 mutants R-HSA-9656223
Oncogenic MAPK signaling R-HSA-6802957
Signalling to ERKs R-HSA-187687
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of FGFR4 signaling R-HSA-5654733
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by FGFR1 R-HSA-5654736
ARMS-mediated activation R-HSA-170984
Negative regulation of MAPK pathway R-HSA-5675221
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by FGFR R-HSA-190236
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR3 signaling R-HSA-5654732
Frs2-mediated activation R-HSA-170968
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Disease R-HSA-1643685
Signaling by FGFR2 R-HSA-5654738
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR1 signaling R-HSA-5654726
RAF activation R-HSA-5673000
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR2 signaling R-HSA-5654727
RAF/MAP kinase cascade R-HSA-5673001
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling downstream of RAS mutants R-HSA-9649948
MAP2K and MAPK activation R-HSA-5674135
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Spry regulation of FGF signaling R-HSA-1295596
Signaling by NTRK1 (TRKA) R-HSA-187037
Prolonged ERK activation events R-HSA-169893
Signaling by RAS mutants R-HSA-6802949
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by MRAS-complex mutants R-HSA-9660537
Signaling by RAF1 mutants R-HSA-9656223
MAPK family signaling cascades R-HSA-5683057
RAF activation R-HSA-5673000
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Negative regulation of FGFR1 signaling R-HSA-5654726
Oncogenic MAPK signaling R-HSA-6802957
Signaling by NTRK1 (TRKA) R-HSA-187037
MAPK family signaling cascades R-HSA-5683057
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Signaling by FGFR3 R-HSA-5654741
Signaling by RAF1 mutants R-HSA-9656223
Signaling by NTRKs R-HSA-166520
Signalling to p38 via RIT and RIN R-HSA-187706
Prolonged ERK activation events R-HSA-169893
Signalling to ERKs R-HSA-187687
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling downstream of RAS mutants R-HSA-9649948
Frs2-mediated activation R-HSA-170968
RAF/MAP kinase cascade R-HSA-5673001
Signaling by BRAF and RAF1 fusions R-HSA-6802952
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signaling by FGFR2 R-HSA-5654738
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by MRAS-complex mutants R-HSA-9660537
ARMS-mediated activation R-HSA-170984
Negative regulation of FGFR4 signaling R-HSA-5654733
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by RAS mutants R-HSA-6802949
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Disease R-HSA-1643685
Signaling by FGFR1 R-HSA-5654736
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR3 signaling R-HSA-5654732
Spry regulation of FGF signaling R-HSA-1295596
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by RAF1 mutants R-HSA-9656223
Signaling by FGFR R-HSA-190236
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
ARMS-mediated activation R-HSA-170984
MAPK1/MAPK3 signaling R-HSA-5684996
Negative regulation of FGFR2 signaling R-HSA-5654727
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK family signaling cascades R-HSA-5683057
Signaling by NTRKs R-HSA-166520
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by RAS mutants R-HSA-6802949
Signaling by FGFR2 R-HSA-5654738
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
Frs2-mediated activation R-HSA-170968
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by FGFR3 R-HSA-5654741
Disease R-HSA-1643685
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by NTRK1 (TRKA) R-HSA-187037
RAF activation R-HSA-5673000
Negative feedback regulation of MAPK pathway R-HSA-5674499
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Signalling to ERKs R-HSA-187687
Negative regulation of FGFR3 signaling R-HSA-5654732
MAP2K and MAPK activation R-HSA-5674135
Signaling by FGFR1 R-HSA-5654736
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by MRAS-complex mutants R-HSA-9660537
Oncogenic MAPK signaling R-HSA-6802957
Negative regulation of MAPK pathway R-HSA-5675221
RAF/MAP kinase cascade R-HSA-5673001
Spry regulation of FGF signaling R-HSA-1295596
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signal Transduction R-HSA-162582
Negative regulation of FGFR1 signaling R-HSA-5654726
Prolonged ERK activation events R-HSA-169893
Signaling by FGFR4 R-HSA-5654743
Disease R-HSA-1643685
Signaling by RAS mutants R-HSA-6802949
Signaling by FGFR4 R-HSA-5654743
Signalling to p38 via RIT and RIN R-HSA-187706
Signaling by FGFR2 R-HSA-5654738
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR1 R-HSA-5654736
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAF1 mutants R-HSA-9656223
Gain-of-function MRAS complexes activate RAF signaling R-HSA-9726842
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Prolonged ERK activation events R-HSA-169893
MAPK family signaling cascades R-HSA-5683057
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR R-HSA-190236
SHOC2 M1731 mutant abolishes MRAS complex function R-HSA-9726840
Negative regulation of MAPK pathway R-HSA-5675221
ARMS-mediated activation R-HSA-170984
Signalling to ERKs R-HSA-187687
Signaling by MRAS-complex mutants R-HSA-9660537
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling downstream of RAS mutants R-HSA-9649948
RAF activation R-HSA-5673000
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by NTRKs R-HSA-166520
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative regulation of FGFR3 signaling R-HSA-5654732
Frs2-mediated activation R-HSA-170968
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAP2K and MAPK activation R-HSA-5674135
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946

Expression Atlas ENSG00000157764
LRG display in Ensembl gene LRG_299
NCBI gene (formerly Entrezgene) 673
GeneCards 1097
HGNC Symbol HGNC:1097
MIM gene 164757
MIM morbid 613707
UniProtKB Gene Name P15056
WikiGene 673
Gene: PDE4C
Ensembl ID : ENSG00000105650
Description: phosphodiesterase 4C
Gene Synonyms: DPDE1
23 APIs:
88 Possible Orthologues:

GPCR downstream signalling R-HSA-388396
Opioid Signalling R-HSA-111885
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
DARPP-32 events R-HSA-180024
Signal Transduction R-HSA-162582
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
G alpha (s) signalling events R-HSA-418555
DARPP-32 events R-HSA-180024
GPCR downstream signalling R-HSA-388396
Opioid Signalling R-HSA-111885
Opioid Signalling R-HSA-111885
DARPP-32 events R-HSA-180024
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
DARPP-32 events R-HSA-180024
Opioid Signalling R-HSA-111885
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
DARPP-32 events R-HSA-180024
G alpha (i) signalling events R-HSA-418594
Signaling by GPCR R-HSA-372790
Opioid Signalling R-HSA-111885
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
DARPP-32 events R-HSA-180024
G alpha (i) signalling events R-HSA-418594
Signal Transduction R-HSA-162582
G alpha (s) signalling events R-HSA-418555
Opioid Signalling R-HSA-111885
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (i) signalling events R-HSA-418594
DARPP-32 events R-HSA-180024
G alpha (s) signalling events R-HSA-418555
Opioid Signalling R-HSA-111885
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
DARPP-32 events R-HSA-180024
G alpha (i) signalling events R-HSA-418594
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Opioid Signalling R-HSA-111885
G alpha (s) signalling events R-HSA-418555

Expression Atlas ENSG00000105650
NCBI gene (formerly Entrezgene) 5143
GeneCards 8782
HGNC Symbol HGNC:8782
MIM gene 600128
UniProtKB Gene Name V9GYP2
WikiGene 5143
Gene: CA12
Ensembl ID : ENSG00000074410
Description: carbonic anhydrase 12
Gene Synonyms: HST18816
5 APIs:
215 Possible Orthologues:

Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029

Expression Atlas ENSG00000074410
NCBI gene (formerly Entrezgene) 771
GeneCards 1371
HGNC Symbol HGNC:1371
MIM gene 603263
MIM morbid 143860
UniProtKB Gene Name O43570
WikiGene 771
Gene: CA7
Ensembl ID : ENSG00000168748
Description: carbonic anhydrase 7
Gene Synonyms:
3 APIs:
221 Possible Orthologues:

Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728

Expression Atlas ENSG00000168748
NCBI gene (formerly Entrezgene) 766
GeneCards 1381
HGNC Symbol HGNC:1381
MIM gene 114770
UniProtKB Gene Name P43166
WikiGene 766
Gene: PDE7B
Ensembl ID : ENSG00000171408
Description: phosphodiesterase 7B
Gene Synonyms:
1 APIs:
174 Possible Orthologues:

Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
Signaling by GPCR R-HSA-372790
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
G alpha (s) signalling events R-HSA-418555
GPCR downstream signalling R-HSA-388396
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signal Transduction R-HSA-162582
G alpha (s) signalling events R-HSA-418555
Signaling by GPCR R-HSA-372790

Expression Atlas ENSG00000171408
NCBI gene (formerly Entrezgene) 27115
GeneCards 8792
HGNC Symbol HGNC:8792
MIM gene 604645
UniProtKB Gene Name Q9NP56
WikiGene 27115
Gene: CDK2
Ensembl ID : ENSG00000123374
Description: cyclin dependent kinase 2
Gene Synonyms:
11 APIs:
203 Possible Orthologues:

G2/M Transition R-HSA-69275
G2 Phase R-HSA-68911
Regulation of mitotic cell cycle R-HSA-453276
PTK6 Regulates Cell Cycle R-HSA-8849470
RNA Polymerase II Transcription R-HSA-73857
S Phase R-HSA-69242
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cellular responses to stimuli R-HSA-8953897
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Generic Transcription Pathway R-HSA-212436
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Hemostasis R-HSA-109582
Signal Transduction R-HSA-162582
Synthesis of DNA R-HSA-69239
DNA Replication R-HSA-69306
Activation of the pre-replicative complex R-HSA-68962
Chromosome Maintenance R-HSA-73886
G1/S DNA Damage Checkpoints R-HSA-69615
DNA Double-Strand Break Repair R-HSA-5693532
DNA Replication Pre-Initiation R-HSA-69002
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
DNA Repair R-HSA-73894
p53-Dependent G1 DNA Damage Response R-HSA-69563
Cellular responses to stress R-HSA-2262752
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
Cyclin E associated events during G1/S transition R-HSA-69202
Regulation of TP53 Degradation R-HSA-6804757
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Mitotic G1 phase and G1/S transition R-HSA-453279
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Switching of origins to a post-replicative state R-HSA-69052
Factors involved in megakaryocyte development and platelet production R-HSA-983231
G2/M Transition R-HSA-69275
G0 and Early G1 R-HSA-1538133
Diseases of mitotic cell cycle R-HSA-9675126
Cyclin D associated events in G1 R-HSA-69231
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Developmental Biology R-HSA-1266738
Transcriptional regulation of granulopoiesis R-HSA-9616222
G1/S Transition R-HSA-69206
Meiosis R-HSA-1500620
Mitotic G2-G2/M phases R-HSA-453274
Regulation of TP53 Activity R-HSA-5633007
Telomere Maintenance R-HSA-157579
Meiotic recombination R-HSA-912446
Cellular Senescence R-HSA-2559583
Cell Cycle Checkpoints R-HSA-69620
Telomere Extension By Telomerase R-HSA-171319
Orc1 removal from chromatin R-HSA-68949
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Disease R-HSA-1643685
G2 Phase R-HSA-68911
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Signaling by PTK6 R-HSA-8848021
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Processing of DNA double-strand break ends R-HSA-5693607
Regulation of TP53 Expression and Degradation R-HSA-6806003
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Reproduction R-HSA-1474165
G1 Phase R-HSA-69236
G2/M Checkpoints R-HSA-69481
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Cell Cycle R-HSA-1640170
Homology Directed Repair R-HSA-5693538
Cell Cycle, Mitotic R-HSA-69278
Activation of ATR in response to replication stress R-HSA-176187
Gene expression (Transcription) R-HSA-74160
Extension of Telomeres R-HSA-180786
Telomere Maintenance R-HSA-157579
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Reproduction R-HSA-1474165
Mitotic G1 phase and G1/S transition R-HSA-453279
Cell Cycle R-HSA-1640170
Regulation of TP53 Expression and Degradation R-HSA-6806003
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by PTK6 R-HSA-8848021
Cellular responses to stimuli R-HSA-8953897
Regulation of TP53 Degradation R-HSA-6804757
Cyclin D associated events in G1 R-HSA-69231
G0 and Early G1 R-HSA-1538133
Factors involved in megakaryocyte development and platelet production R-HSA-983231
G1/S DNA Damage Checkpoints R-HSA-69615
Extension of Telomeres R-HSA-180786
Synthesis of DNA R-HSA-69239
DNA Repair R-HSA-73894
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
DNA Replication R-HSA-69306
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
p53-Dependent G1 DNA Damage Response R-HSA-69563
Developmental Biology R-HSA-1266738
Diseases of mitotic cell cycle R-HSA-9675126
Disease R-HSA-1643685
Regulation of mitotic cell cycle R-HSA-453276
Mitotic G2-G2/M phases R-HSA-453274
G2/M Checkpoints R-HSA-69481
Generic Transcription Pathway R-HSA-212436
Cellular responses to stress R-HSA-2262752
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Meiotic recombination R-HSA-912446
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Regulation of TP53 Activity R-HSA-5633007
Transcriptional regulation of granulopoiesis R-HSA-9616222
PTK6 Regulates Cell Cycle R-HSA-8849470
Cyclin E associated events during G1/S transition R-HSA-69202
Processing of DNA double-strand break ends R-HSA-5693607
Orc1 removal from chromatin R-HSA-68949
Switching of origins to a post-replicative state R-HSA-69052
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Meiosis R-HSA-1500620
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Homology Directed Repair R-HSA-5693538
Activation of the pre-replicative complex R-HSA-68962
G2 Phase R-HSA-68911
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
RNA Polymerase II Transcription R-HSA-73857
Telomere Extension By Telomerase R-HSA-171319
DNA Double-Strand Break Repair R-HSA-5693532
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
S Phase R-HSA-69242
Cell Cycle, Mitotic R-HSA-69278
Activation of ATR in response to replication stress R-HSA-176187
Cellular Senescence R-HSA-2559583
Chromosome Maintenance R-HSA-73886
G1/S Transition R-HSA-69206
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
DNA Replication Pre-Initiation R-HSA-69002
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Hemostasis R-HSA-109582
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
G1 Phase R-HSA-69236
Gene expression (Transcription) R-HSA-74160
Signal Transduction R-HSA-162582
Cell Cycle Checkpoints R-HSA-69620
G0 and Early G1 R-HSA-1538133
Meiotic recombination R-HSA-912446
G2/M Checkpoints R-HSA-69481
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
Developmental Biology R-HSA-1266738
Hemostasis R-HSA-109582
Generic Transcription Pathway R-HSA-212436
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Cyclin E associated events during G1/S transition R-HSA-69202
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Mitotic G2-G2/M phases R-HSA-453274
PTK6 Regulates Cell Cycle R-HSA-8849470
G1 Phase R-HSA-69236
Signal Transduction R-HSA-162582
Orc1 removal from chromatin R-HSA-68949
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Regulation of mitotic cell cycle R-HSA-453276
S Phase R-HSA-69242
Telomere Extension By Telomerase R-HSA-171319
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
Signaling by PTK6 R-HSA-8848021
DNA Replication R-HSA-69306
G1/S Transition R-HSA-69206
Mitotic G1 phase and G1/S transition R-HSA-453279
Activation of ATR in response to replication stress R-HSA-176187
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cell Cycle Checkpoints R-HSA-69620
Processing of DNA double-strand break ends R-HSA-5693607
Gene expression (Transcription) R-HSA-74160
DNA Replication Pre-Initiation R-HSA-69002
Transcriptional Regulation by TP53 R-HSA-3700989
Meiosis R-HSA-1500620
Disease R-HSA-1643685
Switching of origins to a post-replicative state R-HSA-69052
Cyclin D associated events in G1 R-HSA-69231
p53-Dependent G1 DNA Damage Response R-HSA-69563
G1/S DNA Damage Checkpoints R-HSA-69615
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
G2/M Transition R-HSA-69275
Activation of the pre-replicative complex R-HSA-68962
Regulation of TP53 Degradation R-HSA-6804757
DNA Repair R-HSA-73894
RNA Polymerase II Transcription R-HSA-73857
Telomere Maintenance R-HSA-157579
Diseases of mitotic cell cycle R-HSA-9675126
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cellular responses to stimuli R-HSA-8953897
Chromosome Maintenance R-HSA-73886
Extension of Telomeres R-HSA-180786
Homology Directed Repair R-HSA-5693538
Cell Cycle, Mitotic R-HSA-69278
Cellular Senescence R-HSA-2559583
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
DNA Double-Strand Break Repair R-HSA-5693532
Reproduction R-HSA-1474165
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Regulation of TP53 Activity R-HSA-5633007
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Transcriptional regulation of granulopoiesis R-HSA-9616222
Cell Cycle R-HSA-1640170
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Cellular responses to stress R-HSA-2262752
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Synthesis of DNA R-HSA-69239
Regulation of TP53 Expression and Degradation R-HSA-6806003
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Diseases of mitotic cell cycle R-HSA-9675126
DNA Double-Strand Break Repair R-HSA-5693532
Cellular responses to stimuli R-HSA-8953897
Reproduction R-HSA-1474165
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Signal Transduction R-HSA-162582
Cyclin D associated events in G1 R-HSA-69231
Transcriptional regulation of granulopoiesis R-HSA-9616222
DNA Repair R-HSA-73894
Gene expression (Transcription) R-HSA-74160
G2/M Checkpoints R-HSA-69481
Cell Cycle, Mitotic R-HSA-69278
Extension of Telomeres R-HSA-180786
G0 and Early G1 R-HSA-1538133
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
G1/S Transition R-HSA-69206
G2 Phase R-HSA-68911
Cell Cycle R-HSA-1640170
Meiotic recombination R-HSA-912446
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Mitotic G1 phase and G1/S transition R-HSA-453279
G1 Phase R-HSA-69236
Developmental Biology R-HSA-1266738
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
G1/S DNA Damage Checkpoints R-HSA-69615
Processing of DNA double-strand break ends R-HSA-5693607
Telomere Maintenance R-HSA-157579
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Chromosome Maintenance R-HSA-73886
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Signaling by PTK6 R-HSA-8848021
Cellular Senescence R-HSA-2559583
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Synthesis of DNA R-HSA-69239
Cell Cycle Checkpoints R-HSA-69620
Regulation of TP53 Degradation R-HSA-6804757
Cyclin E associated events during G1/S transition R-HSA-69202
Hemostasis R-HSA-109582
p53-Dependent G1 DNA Damage Response R-HSA-69563
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
Meiosis R-HSA-1500620
Telomere Extension By Telomerase R-HSA-171319
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Activation of ATR in response to replication stress R-HSA-176187
Orc1 removal from chromatin R-HSA-68949
Activation of the pre-replicative complex R-HSA-68962
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
PTK6 Regulates Cell Cycle R-HSA-8849470
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
S Phase R-HSA-69242
DNA Replication Pre-Initiation R-HSA-69002
Disease R-HSA-1643685
Regulation of mitotic cell cycle R-HSA-453276
Generic Transcription Pathway R-HSA-212436
Regulation of TP53 Activity R-HSA-5633007
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
G2/M Transition R-HSA-69275
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Switching of origins to a post-replicative state R-HSA-69052
RNA Polymerase II Transcription R-HSA-73857
Mitotic G2-G2/M phases R-HSA-453274
DNA Replication R-HSA-69306
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Homology Directed Repair R-HSA-5693538
Cellular responses to stress R-HSA-2262752
Activation of the pre-replicative complex R-HSA-68962
Cyclin D associated events in G1 R-HSA-69231
Developmental Biology R-HSA-1266738
Cell Cycle R-HSA-1640170
Gene expression (Transcription) R-HSA-74160
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Mitotic G1 phase and G1/S transition R-HSA-453279
G2 Phase R-HSA-68911
DNA Repair R-HSA-73894
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cellular Senescence R-HSA-2559583
Meiotic recombination R-HSA-912446
Processing of DNA double-strand break ends R-HSA-5693607
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Extension of Telomeres R-HSA-180786
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
S Phase R-HSA-69242
Meiosis R-HSA-1500620
DNA Double-Strand Break Repair R-HSA-5693532
Transcriptional Regulation by TP53 R-HSA-3700989
G1/S DNA Damage Checkpoints R-HSA-69615
Telomere Extension By Telomerase R-HSA-171319
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Switching of origins to a post-replicative state R-HSA-69052
Regulation of TP53 Expression and Degradation R-HSA-6806003
Cell Cycle, Mitotic R-HSA-69278
Synthesis of DNA R-HSA-69239
Generic Transcription Pathway R-HSA-212436
DNA Replication Pre-Initiation R-HSA-69002
Orc1 removal from chromatin R-HSA-68949
Cellular responses to stress R-HSA-2262752
Reproduction R-HSA-1474165
Cell Cycle Checkpoints R-HSA-69620
Signaling by PTK6 R-HSA-8848021
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Activation of ATR in response to replication stress R-HSA-176187
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
DNA Replication R-HSA-69306
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Telomere Maintenance R-HSA-157579
Chromosome Maintenance R-HSA-73886
G1 Phase R-HSA-69236
Regulation of TP53 Degradation R-HSA-6804757
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Disease R-HSA-1643685
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
G2/M Transition R-HSA-69275
PTK6 Regulates Cell Cycle R-HSA-8849470
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Hemostasis R-HSA-109582
G2/M Checkpoints R-HSA-69481
Mitotic G2-G2/M phases R-HSA-453274
Cellular responses to stimuli R-HSA-8953897
Homology Directed Repair R-HSA-5693538
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Regulation of mitotic cell cycle R-HSA-453276
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Diseases of mitotic cell cycle R-HSA-9675126
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
G1/S Transition R-HSA-69206
RNA Polymerase II Transcription R-HSA-73857
p53-Dependent G1 DNA Damage Response R-HSA-69563
Regulation of TP53 Activity R-HSA-5633007
Transcriptional regulation of granulopoiesis R-HSA-9616222
Cyclin E associated events during G1/S transition R-HSA-69202
G0 and Early G1 R-HSA-1538133
Signal Transduction R-HSA-162582
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Orc1 removal from chromatin R-HSA-68949
Cyclin E associated events during G1/S transition R-HSA-69202
Meiosis R-HSA-1500620
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Cell Cycle R-HSA-1640170
Telomere Maintenance R-HSA-157579
Reproduction R-HSA-1474165
DNA Double-Strand Break Repair R-HSA-5693532
G2/M Transition R-HSA-69275
Switching of origins to a post-replicative state R-HSA-69052
p53-Dependent G1 DNA Damage Response R-HSA-69563
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Disease R-HSA-1643685
G1 Phase R-HSA-69236
S Phase R-HSA-69242
Developmental Biology R-HSA-1266738
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Diseases of mitotic cell cycle R-HSA-9675126
Cell Cycle Checkpoints R-HSA-69620
Mitotic G1 phase and G1/S transition R-HSA-453279
PTK6 Regulates Cell Cycle R-HSA-8849470
Hemostasis R-HSA-109582
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Transcriptional Regulation by TP53 R-HSA-3700989
Cellular responses to stimuli R-HSA-8953897
Telomere Extension By Telomerase R-HSA-171319
G2/M Checkpoints R-HSA-69481
Synthesis of DNA R-HSA-69239
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
DNA Replication R-HSA-69306
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
Chromosome Maintenance R-HSA-73886
DNA Replication Pre-Initiation R-HSA-69002
G1/S DNA Damage Checkpoints R-HSA-69615
Transcriptional regulation of granulopoiesis R-HSA-9616222
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Extension of Telomeres R-HSA-180786
Processing of DNA double-strand break ends R-HSA-5693607
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Homology Directed Repair R-HSA-5693538
Signal Transduction R-HSA-162582
G0 and Early G1 R-HSA-1538133
Cellular Senescence R-HSA-2559583
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
Regulation of mitotic cell cycle R-HSA-453276
Regulation of TP53 Degradation R-HSA-6804757
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Meiotic recombination R-HSA-912446
DNA Repair R-HSA-73894
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Cyclin D associated events in G1 R-HSA-69231
Mitotic G2-G2/M phases R-HSA-453274
Generic Transcription Pathway R-HSA-212436
Cell Cycle, Mitotic R-HSA-69278
G1/S Transition R-HSA-69206
G2 Phase R-HSA-68911
Activation of ATR in response to replication stress R-HSA-176187
Signaling by PTK6 R-HSA-8848021
Regulation of TP53 Activity R-HSA-5633007
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Cellular responses to stress R-HSA-2262752
Activation of the pre-replicative complex R-HSA-68962
Regulation of TP53 Expression and Degradation R-HSA-6806003
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
G1/S DNA Damage Checkpoints R-HSA-69615
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Diseases of mitotic cell cycle R-HSA-9675126
Activation of ATR in response to replication stress R-HSA-176187
Chromosome Maintenance R-HSA-73886
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
Cellular Senescence R-HSA-2559583
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Cyclin E associated events during G1/S transition R-HSA-69202
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle Checkpoints R-HSA-69620
DNA Repair R-HSA-73894
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
G0 and Early G1 R-HSA-1538133
PTK6 Regulates Cell Cycle R-HSA-8849470
Orc1 removal from chromatin R-HSA-68949
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Cellular responses to stress R-HSA-2262752
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
Disease R-HSA-1643685
Regulation of TP53 Degradation R-HSA-6804757
S Phase R-HSA-69242
Generic Transcription Pathway R-HSA-212436
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription R-HSA-73857
G1/S Transition R-HSA-69206
Processing of DNA double-strand break ends R-HSA-5693607
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cyclin D associated events in G1 R-HSA-69231
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
DNA Replication R-HSA-69306
Synthesis of DNA R-HSA-69239
Regulation of TP53 Activity R-HSA-5633007
G1 Phase R-HSA-69236
Telomere Maintenance R-HSA-157579
DNA Double-Strand Break Repair R-HSA-5693532
Regulation of mitotic cell cycle R-HSA-453276
Meiosis R-HSA-1500620
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Meiotic recombination R-HSA-912446
Activation of the pre-replicative complex R-HSA-68962
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
Cell Cycle R-HSA-1640170
Hemostasis R-HSA-109582
DNA Replication Pre-Initiation R-HSA-69002
G2 Phase R-HSA-68911
G2/M Transition R-HSA-69275
Transcriptional regulation of granulopoiesis R-HSA-9616222
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Mitotic G2-G2/M phases R-HSA-453274
p53-Dependent G1 DNA Damage Response R-HSA-69563
Reproduction R-HSA-1474165
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Regulation of TP53 Expression and Degradation R-HSA-6806003
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
Transcriptional Regulation by TP53 R-HSA-3700989
Telomere Extension By Telomerase R-HSA-171319
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Switching of origins to a post-replicative state R-HSA-69052
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Mitotic G1 phase and G1/S transition R-HSA-453279
Homology Directed Repair R-HSA-5693538
G2/M Checkpoints R-HSA-69481
Extension of Telomeres R-HSA-180786
Cellular responses to stimuli R-HSA-8953897
Signaling by PTK6 R-HSA-8848021
PTK6 Regulates Cell Cycle R-HSA-8849470
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
Mitotic G1 phase and G1/S transition R-HSA-453279
p53-Dependent G1 DNA Damage Response R-HSA-69563
Extension of Telomeres R-HSA-180786
Cyclin D associated events in G1 R-HSA-69231
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
Orc1 removal from chromatin R-HSA-68949
Cellular responses to stimuli R-HSA-8953897
Regulation of mitotic cell cycle R-HSA-453276
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle, Mitotic R-HSA-69278
G0 and Early G1 R-HSA-1538133
Mitotic G2-G2/M phases R-HSA-453274
Activation of ATR in response to replication stress R-HSA-176187
Homology Directed Repair R-HSA-5693538
Meiosis R-HSA-1500620
Synthesis of DNA R-HSA-69239
Cyclin E associated events during G1/S transition R-HSA-69202
G1 Phase R-HSA-69236
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Regulation of TP53 Expression and Degradation R-HSA-6806003
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Transcriptional regulation of granulopoiesis R-HSA-9616222
Regulation of TP53 Degradation R-HSA-6804757
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
DNA Replication R-HSA-69306
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Switching of origins to a post-replicative state R-HSA-69052
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Hemostasis R-HSA-109582
Cell Cycle R-HSA-1640170
G2/M Transition R-HSA-69275
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
DNA Double-Strand Break Repair R-HSA-5693532
Chromosome Maintenance R-HSA-73886
Signal Transduction R-HSA-162582
Diseases of mitotic cell cycle R-HSA-9675126
Reproduction R-HSA-1474165
Signaling by PTK6 R-HSA-8848021
Telomere Maintenance R-HSA-157579
S Phase R-HSA-69242
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
DNA Repair R-HSA-73894
G2 Phase R-HSA-68911
Cellular Senescence R-HSA-2559583
G1/S Transition R-HSA-69206
Telomere Extension By Telomerase R-HSA-171319
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Meiotic recombination R-HSA-912446
Cell Cycle Checkpoints R-HSA-69620
Cellular responses to stress R-HSA-2262752
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
RNA Polymerase II Transcription R-HSA-73857
Processing of DNA double-strand break ends R-HSA-5693607
G1/S DNA Damage Checkpoints R-HSA-69615
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Activation of the pre-replicative complex R-HSA-68962
G2/M Checkpoints R-HSA-69481
Regulation of TP53 Activity R-HSA-5633007
DNA Replication Pre-Initiation R-HSA-69002
Gene expression (Transcription) R-HSA-74160
G2/M Transition R-HSA-69275
Mitotic G1 phase and G1/S transition R-HSA-453279
Hemostasis R-HSA-109582
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
G2/M Checkpoints R-HSA-69481
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
S Phase R-HSA-69242
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle Checkpoints R-HSA-69620
Diseases of mitotic cell cycle R-HSA-9675126
Cell Cycle, Mitotic R-HSA-69278
Reproduction R-HSA-1474165
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
Synthesis of DNA R-HSA-69239
DNA Replication R-HSA-69306
Gene expression (Transcription) R-HSA-74160
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Activation of ATR in response to replication stress R-HSA-176187
Cyclin E associated events during G1/S transition R-HSA-69202
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of TP53 Expression and Degradation R-HSA-6806003
Regulation of TP53 Degradation R-HSA-6804757
G0 and Early G1 R-HSA-1538133
Transcriptional regulation of granulopoiesis R-HSA-9616222
DNA Repair R-HSA-73894
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
G1 Phase R-HSA-69236
Regulation of TP53 Activity R-HSA-5633007
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Chromosome Maintenance R-HSA-73886
Orc1 removal from chromatin R-HSA-68949
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Extension of Telomeres R-HSA-180786
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Regulation of mitotic cell cycle R-HSA-453276
Activation of the pre-replicative complex R-HSA-68962
Transcriptional Regulation by TP53 R-HSA-3700989
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Cell Cycle R-HSA-1640170
Signaling by PTK6 R-HSA-8848021
Developmental Biology R-HSA-1266738
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Cellular Senescence R-HSA-2559583
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Switching of origins to a post-replicative state R-HSA-69052
Disease R-HSA-1643685
p53-Dependent G1 DNA Damage Response R-HSA-69563
Mitotic G2-G2/M phases R-HSA-453274
Meiosis R-HSA-1500620
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
DNA Double-Strand Break Repair R-HSA-5693532
Telomere Maintenance R-HSA-157579
Cyclin D associated events in G1 R-HSA-69231
Homology Directed Repair R-HSA-5693538
G2 Phase R-HSA-68911
G1/S Transition R-HSA-69206
PTK6 Regulates Cell Cycle R-HSA-8849470
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Signal Transduction R-HSA-162582
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
DNA Replication Pre-Initiation R-HSA-69002
Generic Transcription Pathway R-HSA-212436
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Cellular responses to stress R-HSA-2262752
Telomere Extension By Telomerase R-HSA-171319
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Cellular responses to stimuli R-HSA-8953897
Meiotic recombination R-HSA-912446
Processing of DNA double-strand break ends R-HSA-5693607
G1/S DNA Damage Checkpoints R-HSA-69615
G1 Phase R-HSA-69236
Cellular responses to stress R-HSA-2262752
G2/M Transition R-HSA-69275
Orc1 removal from chromatin R-HSA-68949
Diseases of mitotic cell cycle R-HSA-9675126
Regulation of TP53 Degradation R-HSA-6804757
Cyclin D associated events in G1 R-HSA-69231
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
PTK6 Regulates Cell Cycle R-HSA-8849470
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of mitotic cell cycle R-HSA-453276
Factors involved in megakaryocyte development and platelet production R-HSA-983231
Reproduction R-HSA-1474165
Extension of Telomeres R-HSA-180786
DNA Damage/Telomere Stress Induced Senescence R-HSA-2559586
Mitotic G1 phase and G1/S transition R-HSA-453279
Cellular Senescence R-HSA-2559583
Switching of origins to a post-replicative state R-HSA-69052
Hemostasis R-HSA-109582
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Cell Cycle Checkpoints R-HSA-69620
Activation of the pre-replicative complex R-HSA-68962
p53-Dependent G1 DNA Damage Response R-HSA-69563
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Signal Transduction R-HSA-162582
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
G1/S DNA Damage Checkpoints R-HSA-69615
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
DNA Repair R-HSA-73894
Regulation of TP53 Expression and Degradation R-HSA-6806003
G0 and Early G1 R-HSA-1538133
Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) R-HSA-9661069
DNA Double-Strand Break Repair R-HSA-5693532
Meiosis R-HSA-1500620
G2 Phase R-HSA-68911
Homology Directed Repair R-HSA-5693538
Aberrant regulation of mitotic cell cycle due to RB1 defects R-HSA-9687139
Cell Cycle R-HSA-1640170
Meiotic recombination R-HSA-912446
Telomere Extension By Telomerase R-HSA-171319
RNA Polymerase II Transcription R-HSA-73857
Cyclin E associated events during G1/S transition R-HSA-69202
G1/S Transition R-HSA-69206
Activation of ATR in response to replication stress R-HSA-176187
DNA Replication R-HSA-69306
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest R-HSA-6804116
Mitotic G2-G2/M phases R-HSA-453274
Telomere Maintenance R-HSA-157579
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Developmental Biology R-HSA-1266738
Signaling by PTK6 R-HSA-8848021
Generic Transcription Pathway R-HSA-212436
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69200
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects R-HSA-9659787
Disease R-HSA-1643685
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Synthesis of DNA R-HSA-69239
Chromosome Maintenance R-HSA-73886
Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69273
G2/M Checkpoints R-HSA-69481
Transcriptional Regulation by TP53 R-HSA-3700989
Cellular responses to stimuli R-HSA-8953897
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity R-HSA-5633007
DNA Replication Pre-Initiation R-HSA-69002
S Phase R-HSA-69242
Transcriptional regulation of granulopoiesis R-HSA-9616222
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Processing of DNA double-strand break ends R-HSA-5693607
Cell Cycle, Mitotic R-HSA-69278

Expression Atlas ENSG00000123374
NCBI gene (formerly Entrezgene) 1017
GeneCards 1771
HGNC Symbol HGNC:1771
MIM gene 116953
UniProtKB Gene Name P24941
WikiGene 1017
Gene: PTGS1
Ensembl ID : ENSG00000095303
Description: prostaglandin-endoperoxide synthase 1
Gene Synonyms: COX1,PGHS-1,PTGHS
58 APIs:
256 Possible Orthologues:

COX reactions R-HSA-140180
Arachidonic acid metabolism R-HSA-2142753
Fatty acid metabolism R-HSA-8978868
Biological oxidations R-HSA-211859
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Phase I - Functionalization of compounds R-HSA-211945
COX reactions R-HSA-140180
Metabolism R-HSA-1430728
Fatty acid metabolism R-HSA-8978868
Phase I - Functionalization of compounds R-HSA-211945
Metabolism of lipids R-HSA-556833
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Arachidonic acid metabolism R-HSA-2142753
Biological oxidations R-HSA-211859
Metabolism R-HSA-1430728
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Metabolism of lipids R-HSA-556833
COX reactions R-HSA-140180
Fatty acid metabolism R-HSA-8978868
Phase I - Functionalization of compounds R-HSA-211945
Arachidonic acid metabolism R-HSA-2142753
Biological oxidations R-HSA-211859
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Arachidonic acid metabolism R-HSA-2142753
Metabolism of lipids R-HSA-556833
Phase I - Functionalization of compounds R-HSA-211945
Fatty acid metabolism R-HSA-8978868
COX reactions R-HSA-140180
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Phase I - Functionalization of compounds R-HSA-211945
Biological oxidations R-HSA-211859
Arachidonic acid metabolism R-HSA-2142753
Metabolism of lipids R-HSA-556833
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
COX reactions R-HSA-140180
Fatty acid metabolism R-HSA-8978868
Metabolism R-HSA-1430728
Phase I - Functionalization of compounds R-HSA-211945
Fatty acid metabolism R-HSA-8978868
Metabolism R-HSA-1430728
Arachidonic acid metabolism R-HSA-2142753
Biological oxidations R-HSA-211859
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Metabolism of lipids R-HSA-556833
COX reactions R-HSA-140180
Biological oxidations R-HSA-211859
Fatty acid metabolism R-HSA-8978868
Arachidonic acid metabolism R-HSA-2142753
Phase I - Functionalization of compounds R-HSA-211945
Metabolism of lipids R-HSA-556833
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Metabolism R-HSA-1430728
COX reactions R-HSA-140180
Metabolism R-HSA-1430728
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Biological oxidations R-HSA-211859
Arachidonic acid metabolism R-HSA-2142753
Fatty acid metabolism R-HSA-8978868
Phase I - Functionalization of compounds R-HSA-211945
Metabolism of lipids R-HSA-556833
COX reactions R-HSA-140180
Phase I - Functionalization of compounds R-HSA-211945
Arachidonic acid metabolism R-HSA-2142753
COX reactions R-HSA-140180
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Biological oxidations R-HSA-211859
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123
Metabolism R-HSA-1430728
Fatty acid metabolism R-HSA-8978868
Biological oxidations R-HSA-211859
COX reactions R-HSA-140180
Metabolism R-HSA-1430728
Metabolism of lipids R-HSA-556833
Arachidonic acid metabolism R-HSA-2142753
Phase I - Functionalization of compounds R-HSA-211945
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123

Expression Atlas ENSG00000095303
LRG display in Ensembl gene LRG_639
NCBI gene (formerly Entrezgene) 5742
GeneCards 9604
HGNC Symbol HGNC:9604
MIM gene 176805
UniProtKB Gene Name X6RJD6
WikiGene 5742