Gene: CA4
Ensembl ID : ENSG00000167434
Description: carbonic anhydrase 4
Gene Synonyms: CAIV,CAR4,RP17
7 APIs:
334 Possible Orthologues:

Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Transport of small molecules R-HSA-382551
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
O2/CO2 exchange in erythrocytes R-HSA-1480926
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
O2/CO2 exchange in erythrocytes R-HSA-1480926
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Transport of small molecules R-HSA-382551
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Metabolism R-HSA-1430728
Transport of small molecules R-HSA-382551
O2/CO2 exchange in erythrocytes R-HSA-1480926
Reversible hydration of carbon dioxide R-HSA-1475029
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Transport of small molecules R-HSA-382551
O2/CO2 exchange in erythrocytes R-HSA-1480926
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
O2/CO2 exchange in erythrocytes R-HSA-1480926
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Transport of small molecules R-HSA-382551
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Reversible hydration of carbon dioxide R-HSA-1475029
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Transport of small molecules R-HSA-382551
O2/CO2 exchange in erythrocytes R-HSA-1480926
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Transport of small molecules R-HSA-382551
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
O2/CO2 exchange in erythrocytes R-HSA-1480926
Reversible hydration of carbon dioxide R-HSA-1475029
Transport of small molecules R-HSA-382551
Reversible hydration of carbon dioxide R-HSA-1475029
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
O2/CO2 exchange in erythrocytes R-HSA-1480926
Metabolism R-HSA-1430728
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Transport of small molecules R-HSA-382551
O2/CO2 exchange in erythrocytes R-HSA-1480926
Metabolism R-HSA-1430728
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Reversible hydration of carbon dioxide R-HSA-1475029
Erythrocytes take up carbon dioxide and release oxygen R-HSA-1237044
Erythrocytes take up oxygen and release carbon dioxide R-HSA-1247673
Metabolism R-HSA-1430728
O2/CO2 exchange in erythrocytes R-HSA-1480926
Transport of small molecules R-HSA-382551
Reversible hydration of carbon dioxide R-HSA-1475029

Expression Atlas ENSG00000167434
NCBI gene (formerly Entrezgene) 762
GeneCards 1375
HGNC Symbol HGNC:1375
MIM gene 114760
UniProtKB Gene Name P22748
WikiGene 762
Gene: BCR
Ensembl ID : ENSG00000186716
Description: BCR activator of RhoGEF and GTPase
Gene Synonyms: ALL,BCR1,CML,D22S11,D22S662,PHL
8 APIs:
285 Possible Orthologues:

Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOC GTPase cycle R-HSA-9013106
RAC1 GTPase cycle R-HSA-9013149
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RHOA GTPase cycle R-HSA-8980692
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
FGFR1 mutant receptor activation R-HSA-1839124
RAC2 GTPase cycle R-HSA-9013404
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
RHOB GTPase cycle R-HSA-9013026
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOA GTPase cycle R-HSA-8980692
Signaling by Rho GTPases R-HSA-194315
RHOC GTPase cycle R-HSA-9013106
RHOB GTPase cycle R-HSA-9013026
CDC42 GTPase cycle R-HSA-9013148
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
FGFR1 mutant receptor activation R-HSA-1839124
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR1 in disease R-HSA-5655302
RHO GTPase cycle R-HSA-9012999
RAC2 GTPase cycle R-HSA-9013404
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOB GTPase cycle R-HSA-9013026
RAC2 GTPase cycle R-HSA-9013404
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR in disease R-HSA-1226099
RHOA GTPase cycle R-HSA-8980692
RHOC GTPase cycle R-HSA-9013106
CDC42 GTPase cycle R-HSA-9013148
RAC1 GTPase cycle R-HSA-9013149
Signaling by Rho GTPases R-HSA-194315
RAC3 GTPase cycle R-HSA-9013423
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR1 in disease R-HSA-5655302
RAC3 GTPase cycle R-HSA-9013423
RHOB GTPase cycle R-HSA-9013026
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
CDC42 GTPase cycle R-HSA-9013148
RHOA GTPase cycle R-HSA-8980692
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by FGFR1 in disease R-HSA-5655302
Signal Transduction R-HSA-162582
RAC1 GTPase cycle R-HSA-9013149
RHOC GTPase cycle R-HSA-9013106
RAC2 GTPase cycle R-HSA-9013404
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
RAC2 GTPase cycle R-HSA-9013404
RHOA GTPase cycle R-HSA-8980692
Signal Transduction R-HSA-162582
Signaling by Rho GTPases R-HSA-194315
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
RHOC GTPase cycle R-HSA-9013106
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
RAC1 GTPase cycle R-HSA-9013149
FGFR1 mutant receptor activation R-HSA-1839124
RAC3 GTPase cycle R-HSA-9013423
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by Rho GTPases R-HSA-194315
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
CDC42 GTPase cycle R-HSA-9013148
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHO GTPase cycle R-HSA-9012999
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOA GTPase cycle R-HSA-8980692
RHOB GTPase cycle R-HSA-9013026
RHOC GTPase cycle R-HSA-9013106
RAC2 GTPase cycle R-HSA-9013404
Disease R-HSA-1643685
RAC1 GTPase cycle R-HSA-9013149
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases R-HSA-194315
RHOA GTPase cycle R-HSA-8980692
RHOC GTPase cycle R-HSA-9013106
Signaling by FGFR1 in disease R-HSA-5655302
RHOB GTPase cycle R-HSA-9013026
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Signaling by FGFR in disease R-HSA-1226099
RHO GTPase cycle R-HSA-9012999
RAC2 GTPase cycle R-HSA-9013404
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Disease R-HSA-1643685
FGFR1 mutant receptor activation R-HSA-1839124
RHOA GTPase cycle R-HSA-8980692
RHO GTPase cycle R-HSA-9012999
Signal Transduction R-HSA-162582
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC3 GTPase cycle R-HSA-9013423
CDC42 GTPase cycle R-HSA-9013148
RHOC GTPase cycle R-HSA-9013106
Signaling by FGFR in disease R-HSA-1226099
RAC2 GTPase cycle R-HSA-9013404
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
Signaling by Rho GTPases R-HSA-194315
CDC42 GTPase cycle R-HSA-9013148
Disease R-HSA-1643685
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
RAC1 GTPase cycle R-HSA-9013149
Signaling by Rho GTPases R-HSA-194315
Signal Transduction R-HSA-162582
Signaling by FGFR in disease R-HSA-1226099
RHOC GTPase cycle R-HSA-9013106
FGFR1 mutant receptor activation R-HSA-1839124
Signaling by FGFR1 in disease R-HSA-5655302
RAC2 GTPase cycle R-HSA-9013404
RHOA GTPase cycle R-HSA-8980692
RAC3 GTPase cycle R-HSA-9013423
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOB GTPase cycle R-HSA-9013026
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RAC2 GTPase cycle R-HSA-9013404
RHOC GTPase cycle R-HSA-9013106
RHOA GTPase cycle R-HSA-8980692
Signaling by FGFR1 in disease R-HSA-5655302
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Signaling by FGFR in disease R-HSA-1226099
FGFR1 mutant receptor activation R-HSA-1839124
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
RHOB GTPase cycle R-HSA-9013026
RAC1 GTPase cycle R-HSA-9013149
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHO GTPase cycle R-HSA-9012999
RHO GTPase cycle R-HSA-9012999
RHOC GTPase cycle R-HSA-9013106
FGFR1 mutant receptor activation R-HSA-1839124
RAC2 GTPase cycle R-HSA-9013404
Signaling by cytosolic FGFR1 fusion mutants R-HSA-1839117
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR1 in disease R-HSA-5655302
RAC1 GTPase cycle R-HSA-9013149
Signaling by FGFR in disease R-HSA-1226099
Signal Transduction R-HSA-162582
RHOB GTPase cycle R-HSA-9013026
Disease R-HSA-1643685
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOA GTPase cycle R-HSA-8980692

Expression Atlas ENSG00000186716
LRG display in Ensembl gene LRG_1112
NCBI gene (formerly Entrezgene) 613
GeneCards 1014
HGNC Symbol HGNC:1014
MIM gene 151410
MIM morbid 613065
UniProtKB Gene Name P11274
WikiGene 613
Gene: CASP8
Ensembl ID : ENSG00000064012
Description: caspase 8
Gene Synonyms: CASP-8,FLICE,MACH,MCH5
1 APIs:
132 Possible Orthologues:

CLEC7A/inflammasome pathway R-HSA-5660668
Diseases of programmed cell death R-HSA-9645723
NOD1/2 Signaling Pathway R-HSA-168638
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Intrinsic Pathway for Apoptosis R-HSA-109606
Regulation of necroptotic cell death R-HSA-5675482
TRAIL signaling R-HSA-75158
Programmed Cell Death R-HSA-5357801
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Cytokine Signaling in Immune system R-HSA-1280215
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signal Transduction R-HSA-162582
MyD88 cascade initiated on plasma membrane R-HSA-975871
Death Receptor Signaling R-HSA-73887
TRIF-mediated programmed cell death R-HSA-2562578
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TNF signaling R-HSA-75893
FasL/ CD95L signaling R-HSA-75157
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Disease R-HSA-1643685
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Regulated Necrosis R-HSA-5218859
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
Signaling by Interleukins R-HSA-449147
Toll-like Receptor Cascades R-HSA-168898
RIPK1-mediated regulated necrosis R-HSA-5213460
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Regulation of TNFR1 signaling R-HSA-5357905
CASP8 activity is inhibited R-HSA-5218900
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TNFR1-induced proapoptotic signaling R-HSA-5357786
Dimerization of procaspase-8 R-HSA-69416
Apoptotic execution phase R-HSA-75153
Regulation of NF-kappa B signaling R-HSA-9758274
MyD88 dependent cascade initiated on endosome R-HSA-975155
CLEC7A (Dectin-1) signaling R-HSA-5607764
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Interleukin-1 family signaling R-HSA-446652
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
Innate Immune System R-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Apoptotic cleavage of cellular proteins R-HSA-111465
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Immune System R-HSA-168256
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Interleukin-1 signaling R-HSA-9020702
C-type lectin receptors (CLRs) R-HSA-5621481
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Regulation by c-FLIP R-HSA-3371378
Apoptosis R-HSA-109581
TRIF-mediated programmed cell death R-HSA-2562578
Regulation by c-FLIP R-HSA-3371378
Toll-like Receptor Cascades R-HSA-168898
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
Regulation of TNFR1 signaling R-HSA-5357905
Diseases of programmed cell death R-HSA-9645723
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
CASP8 activity is inhibited R-HSA-5218900
CLEC7A/inflammasome pathway R-HSA-5660668
Death Receptor Signaling R-HSA-73887
Innate Immune System R-HSA-168249
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
Immune System R-HSA-168256
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Apoptotic execution phase R-HSA-75153
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Cytokine Signaling in Immune system R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Regulation of NF-kappa B signaling R-HSA-9758274
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
CLEC7A (Dectin-1) signaling R-HSA-5607764
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Interleukin-1 family signaling R-HSA-446652
Apoptotic cleavage of cellular proteins R-HSA-111465
NOD1/2 Signaling Pathway R-HSA-168638
Signal Transduction R-HSA-162582
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Interleukin-1 signaling R-HSA-9020702
TNFR1-induced proapoptotic signaling R-HSA-5357786
FasL/ CD95L signaling R-HSA-75157
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
MyD88 cascade initiated on plasma membrane R-HSA-975871
Regulated Necrosis R-HSA-5218859
Apoptosis R-HSA-109581
Signaling by Interleukins R-HSA-449147
Regulation of necroptotic cell death R-HSA-5675482
C-type lectin receptors (CLRs) R-HSA-5621481
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
RIPK1-mediated regulated necrosis R-HSA-5213460
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
TNF signaling R-HSA-75893
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
TRAIL signaling R-HSA-75158
Intrinsic Pathway for Apoptosis R-HSA-109606
Programmed Cell Death R-HSA-5357801
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88 dependent cascade initiated on endosome R-HSA-975155
Dimerization of procaspase-8 R-HSA-69416
Disease R-HSA-1643685
FasL/ CD95L signaling R-HSA-75157
TNFR1-induced proapoptotic signaling R-HSA-5357786
C-type lectin receptors (CLRs) R-HSA-5621481
Regulation of TNFR1 signaling R-HSA-5357905
MyD88 dependent cascade initiated on endosome R-HSA-975155
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Innate Immune System R-HSA-168249
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
RIPK1-mediated regulated necrosis R-HSA-5213460
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TNF signaling R-HSA-75893
CLEC7A (Dectin-1) signaling R-HSA-5607764
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Death Receptor Signaling R-HSA-73887
MyD88 cascade initiated on plasma membrane R-HSA-975871
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Regulation by c-FLIP R-HSA-3371378
Immune System R-HSA-168256
Diseases of programmed cell death R-HSA-9645723
Apoptotic execution phase R-HSA-75153
Regulation of NF-kappa B signaling R-HSA-9758274
Programmed Cell Death R-HSA-5357801
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
CASP8 activity is inhibited R-HSA-5218900
Apoptosis R-HSA-109581
TRIF-mediated programmed cell death R-HSA-2562578
CLEC7A/inflammasome pathway R-HSA-5660668
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Disease R-HSA-1643685
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAIL signaling R-HSA-75158
Regulated Necrosis R-HSA-5218859
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Interleukin-1 signaling R-HSA-9020702
Intrinsic Pathway for Apoptosis R-HSA-109606
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Cytokine Signaling in Immune system R-HSA-1280215
Signal Transduction R-HSA-162582
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Apoptotic cleavage of cellular proteins R-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Regulation of necroptotic cell death R-HSA-5675482
NOD1/2 Signaling Pathway R-HSA-168638
Dimerization of procaspase-8 R-HSA-69416
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
MyD88-independent TLR4 cascade R-HSA-166166
Interleukin-1 family signaling R-HSA-446652
CASP8 activity is inhibited R-HSA-5218900
CLEC7A (Dectin-1) signaling R-HSA-5607764
TRIF-mediated programmed cell death R-HSA-2562578
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Apoptotic cleavage of cellular proteins R-HSA-111465
TNFR1-induced proapoptotic signaling R-HSA-5357786
Programmed Cell Death R-HSA-5357801
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Regulation by c-FLIP R-HSA-3371378
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
C-type lectin receptors (CLRs) R-HSA-5621481
TRAIL signaling R-HSA-75158
Innate Immune System R-HSA-168249
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Diseases of programmed cell death R-HSA-9645723
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Signal Transduction R-HSA-162582
Cytokine Signaling in Immune system R-HSA-1280215
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
TNF signaling R-HSA-75893
Interleukin-1 family signaling R-HSA-446652
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Disease R-HSA-1643685
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Death Receptor Signaling R-HSA-73887
RIPK1-mediated regulated necrosis R-HSA-5213460
Apoptotic execution phase R-HSA-75153
Regulation of TNFR1 signaling R-HSA-5357905
MyD88 cascade initiated on plasma membrane R-HSA-975871
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
Toll-like Receptor Cascades R-HSA-168898
Dimerization of procaspase-8 R-HSA-69416
NOD1/2 Signaling Pathway R-HSA-168638
Immune System R-HSA-168256
Signaling by Interleukins R-HSA-449147
Regulation of NF-kappa B signaling R-HSA-9758274
Intrinsic Pathway for Apoptosis R-HSA-109606
Regulated Necrosis R-HSA-5218859
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Regulation of necroptotic cell death R-HSA-5675482
MyD88-independent TLR4 cascade R-HSA-166166
FasL/ CD95L signaling R-HSA-75157
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
CLEC7A/inflammasome pathway R-HSA-5660668
Apoptosis R-HSA-109581
C-type lectin receptors (CLRs) R-HSA-5621481
Death Receptor Signaling R-HSA-73887
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TNFR1-induced proapoptotic signaling R-HSA-5357786
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
CLEC7A (Dectin-1) signaling R-HSA-5607764
MyD88 dependent cascade initiated on endosome R-HSA-975155
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Apoptotic cleavage of cellular proteins R-HSA-111465
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
RIPK1-mediated regulated necrosis R-HSA-5213460
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Immune System R-HSA-168256
Programmed Cell Death R-HSA-5357801
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
NOD1/2 Signaling Pathway R-HSA-168638
Cytokine Signaling in Immune system R-HSA-1280215
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Interleukin-1 family signaling R-HSA-446652
TNF signaling R-HSA-75893
Regulation by c-FLIP R-HSA-3371378
CLEC7A/inflammasome pathway R-HSA-5660668
MyD88-independent TLR4 cascade R-HSA-166166
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
CASP8 activity is inhibited R-HSA-5218900
Apoptotic execution phase R-HSA-75153
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Innate Immune System R-HSA-168249
Regulation of necroptotic cell death R-HSA-5675482
Regulation of NF-kappa B signaling R-HSA-9758274
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Dimerization of procaspase-8 R-HSA-69416
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Regulated Necrosis R-HSA-5218859
Intrinsic Pathway for Apoptosis R-HSA-109606
Apoptosis R-HSA-109581
FasL/ CD95L signaling R-HSA-75157
TRAIL signaling R-HSA-75158
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll-like Receptor Cascades R-HSA-168898
MyD88 cascade initiated on plasma membrane R-HSA-975871
TRIF-mediated programmed cell death R-HSA-2562578
Signaling by Interleukins R-HSA-449147
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Interleukin-1 signaling R-HSA-9020702
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Diseases of programmed cell death R-HSA-9645723
Regulation of TNFR1 signaling R-HSA-5357905
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Regulation of TNFR1 signaling R-HSA-5357905
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by Interleukins R-HSA-449147
CLEC7A/inflammasome pathway R-HSA-5660668
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Regulation of NF-kappa B signaling R-HSA-9758274
CLEC7A (Dectin-1) signaling R-HSA-5607764
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
TRIF-mediated programmed cell death R-HSA-2562578
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88 cascade initiated on plasma membrane R-HSA-975871
MyD88-independent TLR4 cascade R-HSA-166166
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Regulation by c-FLIP R-HSA-3371378
Signal Transduction R-HSA-162582
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
NOD1/2 Signaling Pathway R-HSA-168638
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
RIPK1-mediated regulated necrosis R-HSA-5213460
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TNF signaling R-HSA-75893
TNFR1-induced proapoptotic signaling R-HSA-5357786
MyD88 dependent cascade initiated on endosome R-HSA-975155
Disease R-HSA-1643685
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Apoptosis R-HSA-109581
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
Toll-like Receptor Cascades R-HSA-168898
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Regulation of necroptotic cell death R-HSA-5675482
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Apoptotic execution phase R-HSA-75153
Programmed Cell Death R-HSA-5357801
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRAIL signaling R-HSA-75158
FasL/ CD95L signaling R-HSA-75157
CASP8 activity is inhibited R-HSA-5218900
Innate Immune System R-HSA-168249
Dimerization of procaspase-8 R-HSA-69416
Death Receptor Signaling R-HSA-73887
Interleukin-1 signaling R-HSA-9020702
Diseases of programmed cell death R-HSA-9645723
Immune System R-HSA-168256
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Cytokine Signaling in Immune system R-HSA-1280215
Apoptotic cleavage of cellular proteins R-HSA-111465
Regulated Necrosis R-HSA-5218859
Intrinsic Pathway for Apoptosis R-HSA-109606
Interleukin-1 family signaling R-HSA-446652
C-type lectin receptors (CLRs) R-HSA-5621481
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
TNFR1-induced proapoptotic signaling R-HSA-5357786
MyD88-independent TLR4 cascade R-HSA-166166
Regulation by c-FLIP R-HSA-3371378
Regulated Necrosis R-HSA-5218859
FasL/ CD95L signaling R-HSA-75157
Death Receptor Signaling R-HSA-73887
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Signal Transduction R-HSA-162582
Cytokine Signaling in Immune system R-HSA-1280215
Regulation of NF-kappa B signaling R-HSA-9758274
Diseases of programmed cell death R-HSA-9645723
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Immune System R-HSA-168256
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Interleukin-1 family signaling R-HSA-446652
CASP8 activity is inhibited R-HSA-5218900
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Regulation of TNFR1 signaling R-HSA-5357905
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Apoptosis R-HSA-109581
Regulation of necroptotic cell death R-HSA-5675482
Programmed Cell Death R-HSA-5357801
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Interleukin-1 signaling R-HSA-9020702
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Innate Immune System R-HSA-168249
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
CLEC7A (Dectin-1) signaling R-HSA-5607764
Disease R-HSA-1643685
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Apoptotic execution phase R-HSA-75153
NOD1/2 Signaling Pathway R-HSA-168638
TNF signaling R-HSA-75893
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
CLEC7A/inflammasome pathway R-HSA-5660668
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
RIPK1-mediated regulated necrosis R-HSA-5213460
Apoptotic cleavage of cellular proteins R-HSA-111465
MyD88 cascade initiated on plasma membrane R-HSA-975871
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
TRAIL signaling R-HSA-75158
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MyD88 dependent cascade initiated on endosome R-HSA-975155
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Intrinsic Pathway for Apoptosis R-HSA-109606
Signaling by Interleukins R-HSA-449147
Dimerization of procaspase-8 R-HSA-69416
TRIF-mediated programmed cell death R-HSA-2562578
C-type lectin receptors (CLRs) R-HSA-5621481
Toll-like Receptor Cascades R-HSA-168898
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88 dependent cascade initiated on endosome R-HSA-975155
Immune System R-HSA-168256
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
TRAIL signaling R-HSA-75158
CLEC7A (Dectin-1) signaling R-HSA-5607764
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
Signal Transduction R-HSA-162582
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Innate Immune System R-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
RIPK1-mediated regulated necrosis R-HSA-5213460
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Disease R-HSA-1643685
Regulated Necrosis R-HSA-5218859
TNFR1-induced proapoptotic signaling R-HSA-5357786
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Regulation of NF-kappa B signaling R-HSA-9758274
Apoptotic execution phase R-HSA-75153
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
Dimerization of procaspase-8 R-HSA-69416
Regulation of necroptotic cell death R-HSA-5675482
Regulation of TNFR1 signaling R-HSA-5357905
Interleukin-1 signaling R-HSA-9020702
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
C-type lectin receptors (CLRs) R-HSA-5621481
TNF signaling R-HSA-75893
Regulation by c-FLIP R-HSA-3371378
Toll-like Receptor Cascades R-HSA-168898
FasL/ CD95L signaling R-HSA-75157
NOD1/2 Signaling Pathway R-HSA-168638
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
CASP8 activity is inhibited R-HSA-5218900
Apoptosis R-HSA-109581
Intrinsic Pathway for Apoptosis R-HSA-109606
CLEC7A/inflammasome pathway R-HSA-5660668
Death Receptor Signaling R-HSA-73887
Apoptotic cleavage of cellular proteins R-HSA-111465
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Diseases of programmed cell death R-HSA-9645723
Interleukin-1 family signaling R-HSA-446652
TRIF-mediated programmed cell death R-HSA-2562578
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Programmed Cell Death R-HSA-5357801
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Regulated Necrosis R-HSA-5218859
Dimerization of procaspase-8 R-HSA-69416
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Toll-like Receptor Cascades R-HSA-168898
FasL/ CD95L signaling R-HSA-75157
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Regulation of TNFR1 signaling R-HSA-5357905
Disease R-HSA-1643685
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
TNF signaling R-HSA-75893
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signal Transduction R-HSA-162582
MyD88-independent TLR4 cascade R-HSA-166166
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
TRIF-mediated programmed cell death R-HSA-2562578
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
Regulation of NF-kappa B signaling R-HSA-9758274
CASP8 activity is inhibited R-HSA-5218900
NOD1/2 Signaling Pathway R-HSA-168638
Death Receptor Signaling R-HSA-73887
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Regulation by c-FLIP R-HSA-3371378
TRAIL signaling R-HSA-75158
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
Cytokine Signaling in Immune system R-HSA-1280215
Immune System R-HSA-168256
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88 cascade initiated on plasma membrane R-HSA-975871
Apoptotic cleavage of cellular proteins R-HSA-111465
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Signaling by Interleukins R-HSA-449147
Intrinsic Pathway for Apoptosis R-HSA-109606
Interleukin-1 family signaling R-HSA-446652
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Programmed Cell Death R-HSA-5357801
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
Apoptotic execution phase R-HSA-75153
RIPK1-mediated regulated necrosis R-HSA-5213460
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
Apoptosis R-HSA-109581
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
Regulation of necroptotic cell death R-HSA-5675482
CLEC7A (Dectin-1) signaling R-HSA-5607764
Interleukin-1 signaling R-HSA-9020702
CLEC7A/inflammasome pathway R-HSA-5660668
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Innate Immune System R-HSA-168249
C-type lectin receptors (CLRs) R-HSA-5621481
Diseases of programmed cell death R-HSA-9645723
TNFR1-induced proapoptotic signaling R-HSA-5357786
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Regulation by c-FLIP R-HSA-3371378
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Dimerization of procaspase-8 R-HSA-69416
Diseases of programmed cell death R-HSA-9645723
TLR3-mediated TICAM1-dependent programmed cell death R-HSA-9013957
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
C-type lectin receptors (CLRs) R-HSA-5621481
Regulated Necrosis R-HSA-5218859
Interleukin-1 family signaling R-HSA-446652
Programmed Cell Death R-HSA-5357801
Death Receptor Signaling R-HSA-73887
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TAK1-dependent IKK and NF-kappa-B activation R-HSA-445989
DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-168928
RIPK1-mediated regulated necrosis R-HSA-5213460
Caspase activation via Death Receptors in the presence of ligand R-HSA-140534
Innate Immune System R-HSA-168249
Signal Transduction R-HSA-162582
Regulation of TNFR1 signaling R-HSA-5357905
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Signaling by Interleukins R-HSA-449147
Apoptotic execution phase R-HSA-75153
Cytokine Signaling in Immune system R-HSA-1280215
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
NOD1/2 Signaling Pathway R-HSA-168638
Apoptotic cleavage of cellular proteins R-HSA-111465
MyD88 dependent cascade initiated on endosome R-HSA-975155
TRAIL signaling R-HSA-75158
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643
Interleukin-1 signaling R-HSA-9020702
Intrinsic Pathway for Apoptosis R-HSA-109606
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Immune System R-HSA-168256
CASP8 activity is inhibited R-HSA-5218900
Caspase-mediated cleavage of cytoskeletal proteins R-HSA-264870
Defective RIPK1-mediated regulated necrosis R-HSA-9693928
FasL/ CD95L signaling R-HSA-75157
CLEC7A/inflammasome pathway R-HSA-5660668
TNFR1-induced proapoptotic signaling R-HSA-5357786
Disease R-HSA-1643685
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
TRIF-mediated programmed cell death R-HSA-2562578
TNF signaling R-HSA-75893
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Activation, myristolyation of BID and translocation to mitochondria R-HSA-75108
CLEC7A (Dectin-1) signaling R-HSA-5607764
Caspase activation via extrinsic apoptotic signalling pathway R-HSA-5357769
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-933543
Regulation of NF-kappa B signaling R-HSA-9758274
Microbial modulation of RIPK1-mediated regulated necrosis R-HSA-9686347
MyD88-independent TLR4 cascade R-HSA-166166
Regulation of necroptotic cell death R-HSA-5675482
Apoptosis R-HSA-109581
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061

Expression Atlas ENSG00000064012
LRG display in Ensembl gene LRG_34
NCBI gene (formerly Entrezgene) 841
GeneCards 1509
HGNC Symbol HGNC:1509
MIM gene 601763
MIM morbid 607271
UniProtKB Gene Name Q14790
WikiGene 841
Gene: MAPK9
Ensembl ID : ENSG00000050748
Description: mitogen-activated protein kinase 9
Gene Synonyms: JNK2,P54A,PRKM9,SAPK
3 APIs:
219 Possible Orthologues:

Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Activation of the AP-1 family of transcription factors R-HSA-450341
MyD88-independent TLR4 cascade R-HSA-166166
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Immune System R-HSA-168256
Oxidative Stress Induced Senescence R-HSA-2559580
Cytokine Signaling in Immune system R-HSA-1280215
Interleukin-17 signaling R-HSA-448424
MyD88 cascade initiated on plasma membrane R-HSA-975871
Innate Immune System R-HSA-168249
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by Interleukins R-HSA-449147
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Cellular Senescence R-HSA-2559583
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
FCERI mediated MAPK activation R-HSA-2871796
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll-like Receptor Cascades R-HSA-168898
MAP kinase activation R-HSA-450294
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Signaling by Interleukins R-HSA-449147
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
FCERI mediated MAPK activation R-HSA-2871796
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MAP kinase activation R-HSA-450294
Toll-like Receptor Cascades R-HSA-168898
Cytokine Signaling in Immune system R-HSA-1280215
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Activation of the AP-1 family of transcription factors R-HSA-450341
MyD88 dependent cascade initiated on endosome R-HSA-975155
Oxidative Stress Induced Senescence R-HSA-2559580
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Cellular responses to stress R-HSA-2262752
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
MyD88 cascade initiated on plasma membrane R-HSA-975871
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Interleukin-17 signaling R-HSA-448424
Cellular responses to stimuli R-HSA-8953897
Cellular Senescence R-HSA-2559583
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Cellular responses to stress R-HSA-2262752
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88 dependent cascade initiated on endosome R-HSA-975155
MyD88-independent TLR4 cascade R-HSA-166166
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Interleukin-17 signaling R-HSA-448424
Cellular Senescence R-HSA-2559583
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MyD88 cascade initiated on plasma membrane R-HSA-975871
Cytokine Signaling in Immune system R-HSA-1280215
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular responses to stimuli R-HSA-8953897
FCERI mediated MAPK activation R-HSA-2871796
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll-like Receptor Cascades R-HSA-168898
Innate Immune System R-HSA-168249
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
MAP kinase activation R-HSA-450294
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Activation of the AP-1 family of transcription factors R-HSA-450341
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
MyD88 cascade initiated on plasma membrane R-HSA-975871
Cytokine Signaling in Immune system R-HSA-1280215
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Interleukin-17 signaling R-HSA-448424
Oxidative Stress Induced Senescence R-HSA-2559580
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MyD88 dependent cascade initiated on endosome R-HSA-975155
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
MyD88-independent TLR4 cascade R-HSA-166166
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
FCERI mediated MAPK activation R-HSA-2871796
Activation of the AP-1 family of transcription factors R-HSA-450341
Cellular responses to stress R-HSA-2262752
Cellular Senescence R-HSA-2559583
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Cellular responses to stimuli R-HSA-8953897
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Toll-like Receptor Cascades R-HSA-168898
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Immune System R-HSA-168256
Innate Immune System R-HSA-168249
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
MAP kinase activation R-HSA-450294
Signaling by Interleukins R-HSA-449147
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Cellular responses to stress R-HSA-2262752
MAP kinase activation R-HSA-450294
Innate Immune System R-HSA-168249
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Cellular Senescence R-HSA-2559583
FCERI mediated MAPK activation R-HSA-2871796
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Immune System R-HSA-168256
Activation of the AP-1 family of transcription factors R-HSA-450341
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MyD88 cascade initiated on plasma membrane R-HSA-975871
Oxidative Stress Induced Senescence R-HSA-2559580
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Interleukin-17 signaling R-HSA-448424
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Signaling by Interleukins R-HSA-449147
Cellular responses to stimuli R-HSA-8953897
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Cytokine Signaling in Immune system R-HSA-1280215
MyD88-independent TLR4 cascade R-HSA-166166
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Oxidative Stress Induced Senescence R-HSA-2559580
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
FCERI mediated MAPK activation R-HSA-2871796
Activation of the AP-1 family of transcription factors R-HSA-450341
Signaling by Interleukins R-HSA-449147
Immune System R-HSA-168256
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Interleukin-17 signaling R-HSA-448424
Cellular responses to stress R-HSA-2262752
Innate Immune System R-HSA-168249
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Cellular responses to stimuli R-HSA-8953897
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Toll-like Receptor Cascades R-HSA-168898
MyD88 dependent cascade initiated on endosome R-HSA-975155
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Cytokine Signaling in Immune system R-HSA-1280215
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MAP kinase activation R-HSA-450294
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MyD88-independent TLR4 cascade R-HSA-166166
Cellular Senescence R-HSA-2559583
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Cellular responses to stress R-HSA-2262752
MAP kinase activation R-HSA-450294
MyD88 cascade initiated on plasma membrane R-HSA-975871
Activation of the AP-1 family of transcription factors R-HSA-450341
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Immune System R-HSA-168256
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88 dependent cascade initiated on endosome R-HSA-975155
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Interleukin-17 signaling R-HSA-448424
Cellular responses to stimuli R-HSA-8953897
FCERI mediated MAPK activation R-HSA-2871796
Signaling by Interleukins R-HSA-449147
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
MyD88-independent TLR4 cascade R-HSA-166166
Toll-like Receptor Cascades R-HSA-168898
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Oxidative Stress Induced Senescence R-HSA-2559580
Cellular Senescence R-HSA-2559583
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Innate Immune System R-HSA-168249
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
MyD88 cascade initiated on plasma membrane R-HSA-975871
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Activation of the AP-1 family of transcription factors R-HSA-450341
Interleukin-17 signaling R-HSA-448424
Cytokine Signaling in Immune system R-HSA-1280215
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
Cellular responses to stress R-HSA-2262752
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
FCERI mediated MAPK activation R-HSA-2871796
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
MyD88-independent TLR4 cascade R-HSA-166166
Immune System R-HSA-168256
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Signaling by Interleukins R-HSA-449147
Oxidative Stress Induced Senescence R-HSA-2559580
MyD88 dependent cascade initiated on endosome R-HSA-975155
Cellular Senescence R-HSA-2559583
MAP kinase activation R-HSA-450294
Toll-like Receptor Cascades R-HSA-168898
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
Cellular responses to stimuli R-HSA-8953897
Innate Immune System R-HSA-168249
MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166058
Innate Immune System R-HSA-168249
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138
Immune System R-HSA-168256
Oxidative Stress Induced Senescence R-HSA-2559580
Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438
Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176
FCERI mediated MAPK activation R-HSA-2871796
Cytokine Signaling in Immune system R-HSA-1280215
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321
Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181
Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164
Cellular Senescence R-HSA-2559583
Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016
MyD88 dependent cascade initiated on endosome R-HSA-975155
Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138
Interleukin-17 signaling R-HSA-448424
Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179
MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282
TRIF(TICAM1)-mediated TLR4 signaling R-HSA-937061
Cellular responses to stress R-HSA-2262752
Signaling by Interleukins R-HSA-449147
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Cellular responses to stimuli R-HSA-8953897
MyD88 cascade initiated on plasma membrane R-HSA-975871
Activation of the AP-1 family of transcription factors R-HSA-450341
MAP kinase activation R-HSA-450294
Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142
Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188
MyD88-independent TLR4 cascade R-HSA-166166
Toll-like Receptor Cascades R-HSA-168898

Expression Atlas ENSG00000050748
NCBI gene (formerly Entrezgene) 5601
GeneCards 6886
HGNC Symbol HGNC:6886
MIM gene 602896
UniProtKB Gene Name P45984
WikiGene 5601
Gene: MAP3K12
Ensembl ID : ENSG00000139625
Description: mitogen-activated protein kinase kinase kinase 12
Gene Synonyms: DLK,MEKK12,MUK,ZPK,ZPKP1
1 APIs:
254 Possible Orthologues:

Expression Atlas ENSG00000139625
NCBI gene (formerly Entrezgene) 7786
GeneCards 6851
HGNC Symbol HGNC:6851
MIM gene 600447
UniProtKB Gene Name Q12852
WikiGene 7786
Gene: MKNK1
Ensembl ID : ENSG00000079277
Description: MAPK interacting serine/threonine kinase 1
Gene Synonyms: MNK1
1 APIs:
168 Possible Orthologues:

Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR4 R-HSA-5654743
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR4 signaling R-HSA-5654733
Negative regulation of FGFR2 signaling R-HSA-5654727
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR1 R-HSA-5654736
Signaling by FGFR2 R-HSA-5654738
Signaling by FGFR R-HSA-190236
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR1 R-HSA-5654736
Signal Transduction R-HSA-162582
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR3 signaling R-HSA-5654732
Spry regulation of FGF signaling R-HSA-1295596
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Signal Transduction R-HSA-162582
Signaling by FGFR2 R-HSA-5654738
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR2 signaling R-HSA-5654727
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR4 R-HSA-5654743
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR1 R-HSA-5654736
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR3 signaling R-HSA-5654732
Spry regulation of FGF signaling R-HSA-1295596
Signaling by FGFR R-HSA-190236
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR1 signaling R-HSA-5654726
Negative regulation of FGFR2 signaling R-HSA-5654727
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR4 R-HSA-5654743
Signaling by FGFR R-HSA-190236
Signal Transduction R-HSA-162582
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR R-HSA-190236
Signaling by FGFR1 R-HSA-5654736
Signaling by FGFR3 R-HSA-5654741
Negative regulation of FGFR2 signaling R-HSA-5654727
Signal Transduction R-HSA-162582
Signaling by FGFR4 R-HSA-5654743
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR1 signaling R-HSA-5654726
Signaling by FGFR2 R-HSA-5654738
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR R-HSA-190236
Negative regulation of FGFR1 signaling R-HSA-5654726
Signal Transduction R-HSA-162582
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR4 R-HSA-5654743
Spry regulation of FGF signaling R-HSA-1295596
Spry regulation of FGF signaling R-HSA-1295596
Negative regulation of FGFR2 signaling R-HSA-5654727
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR2 R-HSA-5654738
Signal Transduction R-HSA-162582
Signaling by FGFR1 R-HSA-5654736
Negative regulation of FGFR3 signaling R-HSA-5654732
Signaling by FGFR R-HSA-190236
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of FGFR4 signaling R-HSA-5654733
Signaling by FGFR4 R-HSA-5654743
Negative regulation of FGFR1 signaling R-HSA-5654726

Expression Atlas ENSG00000079277
NCBI gene (formerly Entrezgene) 8569
GeneCards 7110
HGNC Symbol HGNC:7110
MIM gene 606724
UniProtKB Gene Name Q9BUB5
WikiGene 8569
Gene: KDR
Ensembl ID : ENSG00000128052
Description: kinase insert domain receptor
Gene Synonyms: CD309,FLK1,VEGFR,VEGFR2
71 APIs:
199 Possible Orthologues:

VEGFR2 mediated cell proliferation R-HSA-5218921
Signaling by VEGF R-HSA-194138
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
VEGF ligand-receptor interactions R-HSA-194313
Extracellular matrix organization R-HSA-1474244
VEGFA-VEGFR2 Pathway R-HSA-4420097
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
Integrin cell surface interactions R-HSA-216083
Signaling by PDGFR in disease R-HSA-9671555
Integrin cell surface interactions R-HSA-216083
VEGFR2 mediated cell proliferation R-HSA-5218921
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
VEGFA-VEGFR2 Pathway R-HSA-4420097
Disease R-HSA-1643685
Extracellular matrix organization R-HSA-1474244
VEGF ligand-receptor interactions R-HSA-194313
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by VEGF R-HSA-194138
Signaling by PDGFR in disease R-HSA-9671555
Signal Transduction R-HSA-162582
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGFA-VEGFR2 Pathway R-HSA-4420097
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by VEGF R-HSA-194138
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
VEGF ligand-receptor interactions R-HSA-194313
Signaling by PDGFR in disease R-HSA-9671555
Signal Transduction R-HSA-162582
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
VEGFR2 mediated cell proliferation R-HSA-5218921
Integrin cell surface interactions R-HSA-216083
Extracellular matrix organization R-HSA-1474244
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGFR2 mediated cell proliferation R-HSA-5218921
Signaling by VEGF R-HSA-194138
VEGFA-VEGFR2 Pathway R-HSA-4420097
Integrin cell surface interactions R-HSA-216083
VEGF ligand-receptor interactions R-HSA-194313
Extracellular matrix organization R-HSA-1474244
Disease R-HSA-1643685
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signal Transduction R-HSA-162582
Signaling by PDGFR in disease R-HSA-9671555
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
Signal Transduction R-HSA-162582
VEGFA-VEGFR2 Pathway R-HSA-4420097
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Integrin cell surface interactions R-HSA-216083
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by PDGFR in disease R-HSA-9671555
VEGF ligand-receptor interactions R-HSA-194313
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
VEGFR2 mediated cell proliferation R-HSA-5218921
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signaling by VEGF R-HSA-194138
Extracellular matrix organization R-HSA-1474244
Signaling by VEGF R-HSA-194138
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGF ligand-receptor interactions R-HSA-194313
Signal Transduction R-HSA-162582
VEGFR2 mediated cell proliferation R-HSA-5218921
Integrin cell surface interactions R-HSA-216083
Signaling by PDGFR in disease R-HSA-9671555
Extracellular matrix organization R-HSA-1474244
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
VEGFA-VEGFR2 Pathway R-HSA-4420097
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Disease R-HSA-1643685
Integrin cell surface interactions R-HSA-216083
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
VEGFR2 mediated cell proliferation R-HSA-5218921
Extracellular matrix organization R-HSA-1474244
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signaling by VEGF R-HSA-194138
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by PDGFR in disease R-HSA-9671555
VEGF ligand-receptor interactions R-HSA-194313
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
VEGFA-VEGFR2 Pathway R-HSA-4420097
Integrin cell surface interactions R-HSA-216083
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by PDGFR in disease R-HSA-9671555
VEGF ligand-receptor interactions R-HSA-194313
Signaling by VEGF R-HSA-194138
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
VEGFR2 mediated cell proliferation R-HSA-5218921
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
VEGFA-VEGFR2 Pathway R-HSA-4420097
Extracellular matrix organization R-HSA-1474244
Signal Transduction R-HSA-162582
Disease R-HSA-1643685
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
VEGF ligand-receptor interactions R-HSA-194313
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
VEGFR2 mediated cell proliferation R-HSA-5218921
Integrin cell surface interactions R-HSA-216083
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Signal Transduction R-HSA-162582
Signaling by VEGF R-HSA-194138
Extracellular matrix organization R-HSA-1474244
Signaling by PDGFR in disease R-HSA-9671555
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signal Transduction R-HSA-162582
VEGFA-VEGFR2 Pathway R-HSA-4420097
VEGF binds to VEGFR leading to receptor dimerization R-HSA-195399
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
VEGFR2 mediated cell proliferation R-HSA-5218921
Neurophilin interactions with VEGF and VEGFR R-HSA-194306
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB R-HSA-9673768
Signaling by PDGFR in disease R-HSA-9671555
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by VEGF R-HSA-194138
Integrin cell surface interactions R-HSA-216083
VEGF ligand-receptor interactions R-HSA-194313
Extracellular matrix organization R-HSA-1474244
Disease R-HSA-1643685

Expression Atlas ENSG00000128052
LRG display in Ensembl gene LRG_1198
NCBI gene (formerly Entrezgene) 3791
GeneCards 6307
HGNC Symbol HGNC:6307
MIM gene 191306
MIM morbid 602089
UniProtKB Gene Name P35968
WikiGene 3791
Gene: LTA4H
Ensembl ID : ENSG00000111144
Description: leukotriene A4 hydrolase
Gene Synonyms:
1 APIs:
207 Possible Orthologues:

Biosynthesis of DHA-derived SPMs R-HSA-9018677
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Metabolism R-HSA-1430728
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Metabolism of lipids R-HSA-556833
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Biosynthesis of D-series resolvins R-HSA-9018676
Biosynthesis of protectins R-HSA-9018681
Fatty acid metabolism R-HSA-8978868
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Metabolism of lipids R-HSA-556833
Biosynthesis of protectins R-HSA-9018681
Neutrophil degranulation R-HSA-6798695
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Fatty acid metabolism R-HSA-8978868
Biosynthesis of D-series resolvins R-HSA-9018676
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Metabolism R-HSA-1430728
Innate Immune System R-HSA-168249
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Arachidonic acid metabolism R-HSA-2142753
Fatty acid metabolism R-HSA-8978868
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of D-series resolvins R-HSA-9018676
Immune System R-HSA-168256
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Neutrophil degranulation R-HSA-6798695
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of protectins R-HSA-9018681
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Innate Immune System R-HSA-168249
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of protectins R-HSA-9018681
Metabolism R-HSA-1430728
Biosynthesis of D-series resolvins R-HSA-9018676
Metabolism of lipids R-HSA-556833
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Fatty acid metabolism R-HSA-8978868
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Innate Immune System R-HSA-168249
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of D-series resolvins R-HSA-9018676
Neutrophil degranulation R-HSA-6798695
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Biosynthesis of protectins R-HSA-9018681
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Metabolism of lipids R-HSA-556833
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Fatty acid metabolism R-HSA-8978868
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Metabolism R-HSA-1430728
Immune System R-HSA-168256
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Fatty acid metabolism R-HSA-8978868
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Metabolism R-HSA-1430728
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Immune System R-HSA-168256
Biosynthesis of D-series resolvins R-HSA-9018676
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Innate Immune System R-HSA-168249
Biosynthesis of protectins R-HSA-9018681
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Neutrophil degranulation R-HSA-6798695
Metabolism of lipids R-HSA-556833
Arachidonic acid metabolism R-HSA-2142753
Fatty acid metabolism R-HSA-8978868
Immune System R-HSA-168256
Metabolism of lipids R-HSA-556833
Metabolism R-HSA-1430728
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of protectins R-HSA-9018681
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Biosynthesis of D-series resolvins R-HSA-9018676
Innate Immune System R-HSA-168249
Neutrophil degranulation R-HSA-6798695
Biosynthesis of protectins R-HSA-9018681
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Metabolism of lipids R-HSA-556833
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Innate Immune System R-HSA-168249
Biosynthesis of D-series resolvins R-HSA-9018676
Neutrophil degranulation R-HSA-6798695
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Arachidonic acid metabolism R-HSA-2142753
Immune System R-HSA-168256
Metabolism R-HSA-1430728
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Fatty acid metabolism R-HSA-8978868
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of D-series resolvins R-HSA-9018676
Metabolism R-HSA-1430728
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Fatty acid metabolism R-HSA-8978868
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Metabolism of lipids R-HSA-556833
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Immune System R-HSA-168256
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Neutrophil degranulation R-HSA-6798695
Biosynthesis of protectins R-HSA-9018681
Innate Immune System R-HSA-168249
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Fatty acid metabolism R-HSA-8978868
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Neutrophil degranulation R-HSA-6798695
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Immune System R-HSA-168256
Biosynthesis of D-series resolvins R-HSA-9018676
Metabolism R-HSA-1430728
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Metabolism of lipids R-HSA-556833
Innate Immune System R-HSA-168249
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Biosynthesis of protectins R-HSA-9018681
Arachidonic acid metabolism R-HSA-2142753
Fatty acid metabolism R-HSA-8978868
Biosynthesis of EPA-derived SPMs R-HSA-9018679
Arachidonic acid metabolism R-HSA-2142753
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Innate Immune System R-HSA-168249
Biosynthesis of E-series 18(S)-resolvins R-HSA-9018896
Biosynthesis of aspirin-triggered D-series resolvins R-HSA-9020265
Biosynthesis of protectins R-HSA-9018681
Metabolism R-HSA-1430728
Biosynthesis of E-series 18(R)-resolvins R-HSA-9023661
Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Metabolism of lipids R-HSA-556833
Biosynthesis of D-series resolvins R-HSA-9018676

Expression Atlas ENSG00000111144
NCBI gene (formerly Entrezgene) 4048
GeneCards 6710
HGNC Symbol HGNC:6710
MIM gene 151570
UniProtKB Gene Name P09960
WikiGene 4048