Gene: SEM1
Ensembl ID : ENSG00000127922
Description: SEM1 26S proteasome subunit
Gene Synonyms: C7ORF76,DSS1,ECD,FLJ42280,PSMD15,SHFD1,SHFDG1,SHFM1,SHSF1
5 APIs:
156 Possible Orthologues:

Synthesis of DNA R-HSA-69239
Degradation of AXIN R-HSA-4641257
Metabolism R-HSA-1430728
Signaling by NOTCH R-HSA-157118
PTEN Regulation R-HSA-6807070
Transcriptional regulation by RUNX3 R-HSA-8878159
NIK-->noncanonical NF-kB signaling R-HSA-5676590
Metabolism R-HSA-1430728
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Post-translational protein modification R-HSA-597592
Programmed Cell Death R-HSA-5357801
G2/M Transition R-HSA-69275
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
TCR signaling R-HSA-202403
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Signaling by ROBO receptors R-HSA-376176
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Hedgehog ligand biogenesis R-HSA-5358346
Degradation of GLI2 by the proteasome R-HSA-5610783
G1/S Transition R-HSA-69206
Mitotic Metaphase and Anaphase R-HSA-2555396
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Signaling by NOTCH R-HSA-157118
Signaling by WNT R-HSA-195721
Metabolism of RNA R-HSA-8953854
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Downstream TCR signaling R-HSA-202424
Homology Directed Repair R-HSA-5693538
Host Interactions of HIV factors R-HSA-162909
Regulation of RUNX3 expression and activity R-HSA-8941858
C-type lectin receptors (CLRs) R-HSA-5621481
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Degradation of GLI1 by the proteasome R-HSA-5610780
FCERI mediated NF-kB activation R-HSA-2871837
Antigen processing-Cross presentation R-HSA-1236975
Metabolism of amino acids and derivatives R-HSA-71291
S Phase R-HSA-69242
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Hh mutants are degraded by ERAD R-HSA-5362768
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
Regulation of expression of SLITs and ROBOs R-HSA-9010553
RNA Polymerase II Transcription R-HSA-73857
Cell Cycle, Mitotic R-HSA-69278
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Asymmetric localization of PCP proteins R-HSA-4608870
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Neddylation R-HSA-8951664
TCF dependent signaling in response to WNT R-HSA-201681
DNA Replication R-HSA-69306
PTEN Regulation R-HSA-6807070
CLEC7A (Dectin-1) signaling R-HSA-5607764
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
RAF/MAP kinase cascade R-HSA-5673001
p53-Independent DNA Damage Response R-HSA-69610
DNA Double-Strand Break Repair R-HSA-5693532
Developmental Biology R-HSA-1266738
Degradation of DVL R-HSA-4641258
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Separation of Sister Chromatids R-HSA-2467813
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Assembly of the pre-replicative complex R-HSA-68867
G1/S DNA Damage Checkpoints R-HSA-69615
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
UCH proteinases R-HSA-5689603
Beta-catenin independent WNT signaling R-HSA-3858494
Cellular responses to stress R-HSA-2262752
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular response to hypoxia R-HSA-1234174
Hedgehog 'off' state R-HSA-5610787
ABC transporter disorders R-HSA-5619084
Cellular responses to stimuli R-HSA-8953897
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Mitotic G1 phase and G1/S transition R-HSA-453279
Gene expression (Transcription) R-HSA-74160
MAPK1/MAPK3 signaling R-HSA-5684996
Defective CFTR causes cystic fibrosis R-HSA-5678895
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
HDR through Homologous Recombination (HRR) R-HSA-5685942
Intracellular signaling by second messengers R-HSA-9006925
Vif-mediated degradation of APOBEC3G R-HSA-180585
Transport of small molecules R-HSA-382551
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Degradation of beta-catenin by the destruction complex R-HSA-195253
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Interleukin-1 family signaling R-HSA-446652
Interleukin-1 signaling R-HSA-9020702
Hh mutants abrogate ligand secretion R-HSA-5387390
Switching of origins to a post-replicative state R-HSA-69052
Apoptosis R-HSA-109581
Mitotic G2-G2/M phases R-HSA-453274
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Transcriptional regulation by RUNX1 R-HSA-8878171
Signaling by NOTCH4 R-HSA-9013694
Axon guidance R-HSA-422475
Transcriptional regulation by RUNX2 R-HSA-8878166
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Cell Cycle R-HSA-1640170
Degradation of AXIN R-HSA-4641257
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
Regulation of RUNX2 expression and activity R-HSA-8939902
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
PIP3 activates AKT signaling R-HSA-1257604
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Signaling by Interleukins R-HSA-449147
Infectious disease R-HSA-5663205
Ub-specific processing proteases R-HSA-5689880
Nervous system development R-HSA-9675108
Nuclear events mediated by NFE2L2 R-HSA-9759194
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
ABC-family proteins mediated transport R-HSA-382556
Regulation of Apoptosis R-HSA-169911
Regulation of RAS by GAPs R-HSA-5658442
Class I MHC mediated antigen processing & presentation R-HSA-983169
Disease R-HSA-1643685
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
M Phase R-HSA-68886
Negative regulation of NOTCH4 signaling R-HSA-9604323
Vpu mediated degradation of CD4 R-HSA-180534
Regulation of mitotic cell cycle R-HSA-453276
Adaptive Immune System R-HSA-1280218
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Metabolism of polyamines R-HSA-351202
DNA Repair R-HSA-73894
ER-Phagosome pathway R-HSA-1236974
Stabilization of p53 R-HSA-69541
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
PCP/CE pathway R-HSA-4086400
Regulation of PTEN stability and activity R-HSA-8948751
Immune System R-HSA-168256
Deubiquitination R-HSA-5688426
Hedgehog 'on' state R-HSA-5632684
MAPK6/MAPK4 signaling R-HSA-5687128
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Metabolism of proteins R-HSA-392499
Innate Immune System R-HSA-168249
DNA Replication Pre-Initiation R-HSA-69002
Resolution of D-Loop Structures R-HSA-5693537
G2/M Checkpoints R-HSA-69481
MAPK family signaling cascades R-HSA-5683057
Signaling by Hedgehog R-HSA-5358351
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
Generic Transcription Pathway R-HSA-212436
Cell Cycle Checkpoints R-HSA-69620
Disorders of transmembrane transporters R-HSA-5619115
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Signal Transduction R-HSA-162582
KEAP1-NFE2L2 pathway R-HSA-9755511
Cellular response to chemical stress R-HSA-9711123
Cyclin E associated events during G1/S transition R-HSA-69202
Orc1 removal from chromatin R-HSA-68949
HIV Infection R-HSA-162906
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Activation of NF-kappaB in B cells R-HSA-1169091
Diseases of DNA repair R-HSA-9675135
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Mitotic Anaphase R-HSA-68882
Cytokine Signaling in Immune system R-HSA-1280215
p53-Dependent G1 DNA Damage Response R-HSA-69563
Assembly of the pre-replicative complex R-HSA-68867
Disorders of transmembrane transporters R-HSA-5619115
NIK-->noncanonical NF-kB signaling R-HSA-5676590
Hh mutants abrogate ligand secretion R-HSA-5387390
KEAP1-NFE2L2 pathway R-HSA-9755511
Mitotic G2-G2/M phases R-HSA-453274
Cellular responses to stress R-HSA-2262752
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
Signaling by Hedgehog R-HSA-5358351
DNA Replication R-HSA-69306
S Phase R-HSA-69242
Regulation of RAS by GAPs R-HSA-5658442
Degradation of DVL R-HSA-4641258
Cell Cycle R-HSA-1640170
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Neddylation R-HSA-8951664
DNA Replication Pre-Initiation R-HSA-69002
p53-Independent DNA Damage Response R-HSA-69610
Programmed Cell Death R-HSA-5357801
Metabolism of polyamines R-HSA-351202
Generic Transcription Pathway R-HSA-212436
RAF/MAP kinase cascade R-HSA-5673001
PCP/CE pathway R-HSA-4086400
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Apoptosis R-HSA-109581
Signaling by the B Cell Receptor (BCR) R-HSA-983705
MAPK6/MAPK4 signaling R-HSA-5687128
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Cytokine Signaling in Immune system R-HSA-1280215
Degradation of beta-catenin by the destruction complex R-HSA-195253
HIV Infection R-HSA-162906
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Cyclin E associated events during G1/S transition R-HSA-69202
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
Signal Transduction R-HSA-162582
Homology Directed Repair R-HSA-5693538
Interleukin-1 family signaling R-HSA-446652
M Phase R-HSA-68886
Vpu mediated degradation of CD4 R-HSA-180534
Developmental Biology R-HSA-1266738
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
UCH proteinases R-HSA-5689603
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
G2/M Transition R-HSA-69275
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Interleukin-1 signaling R-HSA-9020702
Degradation of GLI1 by the proteasome R-HSA-5610780
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Cellular response to hypoxia R-HSA-1234174
Innate Immune System R-HSA-168249
Axon guidance R-HSA-422475
Regulation of RUNX3 expression and activity R-HSA-8941858
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
TCR signaling R-HSA-202403
Cell Cycle, Mitotic R-HSA-69278
Metabolism of RNA R-HSA-8953854
Cellular response to chemical stress R-HSA-9711123
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
CLEC7A (Dectin-1) signaling R-HSA-5607764
Deubiquitination R-HSA-5688426
Orc1 removal from chromatin R-HSA-68949
Signaling by ROBO receptors R-HSA-376176
p53-Dependent G1 DNA Damage Response R-HSA-69563
Regulation of mitotic cell cycle R-HSA-453276
Disease R-HSA-1643685
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Separation of Sister Chromatids R-HSA-2467813
G1/S DNA Damage Checkpoints R-HSA-69615
Nervous system development R-HSA-9675108
Cell Cycle Checkpoints R-HSA-69620
MAPK1/MAPK3 signaling R-HSA-5684996
Transcriptional regulation by RUNX1 R-HSA-8878171
Signaling by NOTCH4 R-HSA-9013694
Signaling by NOTCH R-HSA-157118
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Negative regulation of NOTCH4 signaling R-HSA-9604323
FCERI mediated NF-kB activation R-HSA-2871837
Stabilization of p53 R-HSA-69541
HDR through Homologous Recombination (HRR) R-HSA-5685942
TCF dependent signaling in response to WNT R-HSA-201681
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
PIP3 activates AKT signaling R-HSA-1257604
Transcriptional regulation by RUNX2 R-HSA-8878166
Hedgehog ligand biogenesis R-HSA-5358346
Diseases of DNA repair R-HSA-9675135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
DNA Double-Strand Break Repair R-HSA-5693532
G1/S Transition R-HSA-69206
Hh mutants are degraded by ERAD R-HSA-5362768
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
DNA Repair R-HSA-73894
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Activation of NF-kappaB in B cells R-HSA-1169091
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Resolution of D-Loop Structures R-HSA-5693537
Signaling by Interleukins R-HSA-449147
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Metabolism R-HSA-1430728
Regulation of PTEN stability and activity R-HSA-8948751
Nuclear events mediated by NFE2L2 R-HSA-9759194
RNA Polymerase II Transcription R-HSA-73857
Antigen processing-Cross presentation R-HSA-1236975
Mitotic G1 phase and G1/S transition R-HSA-453279
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
Downstream TCR signaling R-HSA-202424
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Degradation of GLI2 by the proteasome R-HSA-5610783
Gene expression (Transcription) R-HSA-74160
ABC-family proteins mediated transport R-HSA-382556
Synthesis of DNA R-HSA-69239
Metabolism of proteins R-HSA-392499
Beta-catenin independent WNT signaling R-HSA-3858494
Mitotic Metaphase and Anaphase R-HSA-2555396
Metabolism of amino acids and derivatives R-HSA-71291
Hedgehog 'on' state R-HSA-5632684
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
ABC transporter disorders R-HSA-5619084
Cellular responses to stimuli R-HSA-8953897
Class I MHC mediated antigen processing & presentation R-HSA-983169
Transport of small molecules R-HSA-382551
PTEN Regulation R-HSA-6807070
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Vif-mediated degradation of APOBEC3G R-HSA-180585
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Immune System R-HSA-168256
MAPK family signaling cascades R-HSA-5683057
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Infectious disease R-HSA-5663205
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
G2/M Checkpoints R-HSA-69481
ER-Phagosome pathway R-HSA-1236974
Regulation of Apoptosis R-HSA-169911
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Switching of origins to a post-replicative state R-HSA-69052
Intracellular signaling by second messengers R-HSA-9006925
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Post-translational protein modification R-HSA-597592
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Hedgehog 'off' state R-HSA-5610787
C-type lectin receptors (CLRs) R-HSA-5621481
Adaptive Immune System R-HSA-1280218
Defective CFTR causes cystic fibrosis R-HSA-5678895
Mitotic Anaphase R-HSA-68882
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
Ub-specific processing proteases R-HSA-5689880
Host Interactions of HIV factors R-HSA-162909
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Asymmetric localization of PCP proteins R-HSA-4608870
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Signaling by WNT R-HSA-195721
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Transcriptional regulation by RUNX3 R-HSA-8878159
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Regulation of RUNX2 expression and activity R-HSA-8939902
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Orc1 removal from chromatin R-HSA-68949
Developmental Biology R-HSA-1266738
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
G1/S Transition R-HSA-69206
Metabolism of amino acids and derivatives R-HSA-71291
Activation of NF-kappaB in B cells R-HSA-1169091
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Regulation of Apoptosis R-HSA-169911
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
Signaling by WNT R-HSA-195721
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Gene expression (Transcription) R-HSA-74160
Cellular response to hypoxia R-HSA-1234174
HDR through Homologous Recombination (HRR) R-HSA-5685942
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
RAF/MAP kinase cascade R-HSA-5673001
MAPK family signaling cascades R-HSA-5683057
Hedgehog ligand biogenesis R-HSA-5358346
PTEN Regulation R-HSA-6807070
Assembly of the pre-replicative complex R-HSA-68867
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
G2/M Transition R-HSA-69275
Cyclin E associated events during G1/S transition R-HSA-69202
G2/M Checkpoints R-HSA-69481
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NOTCH R-HSA-157118
FCERI mediated NF-kB activation R-HSA-2871837
Cell Cycle Checkpoints R-HSA-69620
TCF dependent signaling in response to WNT R-HSA-201681
Cytokine Signaling in Immune system R-HSA-1280215
NIK-->noncanonical NF-kB signaling R-HSA-5676590
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
HIV Infection R-HSA-162906
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Transcriptional regulation by RUNX2 R-HSA-8878166
Metabolism of RNA R-HSA-8953854
TCR signaling R-HSA-202403
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Cell Cycle R-HSA-1640170
DNA Double-Strand Break Repair R-HSA-5693532
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Diseases of DNA repair R-HSA-9675135
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Disease R-HSA-1643685
Antigen processing-Cross presentation R-HSA-1236975
MAPK6/MAPK4 signaling R-HSA-5687128
Post-translational protein modification R-HSA-597592
Class I MHC mediated antigen processing & presentation R-HSA-983169
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Interleukin-1 family signaling R-HSA-446652
Generic Transcription Pathway R-HSA-212436
Transport of small molecules R-HSA-382551
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Intracellular signaling by second messengers R-HSA-9006925
ER-Phagosome pathway R-HSA-1236974
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
CLEC7A (Dectin-1) signaling R-HSA-5607764
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Mitotic G1 phase and G1/S transition R-HSA-453279
Innate Immune System R-HSA-168249
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Downstream TCR signaling R-HSA-202424
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
ABC-family proteins mediated transport R-HSA-382556
Metabolism of polyamines R-HSA-351202
Adaptive Immune System R-HSA-1280218
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Negative regulation of NOTCH4 signaling R-HSA-9604323
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Switching of origins to a post-replicative state R-HSA-69052
Cell Cycle, Mitotic R-HSA-69278
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Cellular responses to stimuli R-HSA-8953897
Regulation of mitotic cell cycle R-HSA-453276
G1/S DNA Damage Checkpoints R-HSA-69615
Host Interactions of HIV factors R-HSA-162909
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Neddylation R-HSA-8951664
Signaling by Interleukins R-HSA-449147
Deubiquitination R-HSA-5688426
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
DNA Replication Pre-Initiation R-HSA-69002
Degradation of GLI1 by the proteasome R-HSA-5610780
Regulation of RUNX3 expression and activity R-HSA-8941858
Regulation of RAS by GAPs R-HSA-5658442
Signaling by ROBO receptors R-HSA-376176
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
p53-Dependent G1 DNA Damage Response R-HSA-69563
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Vpu mediated degradation of CD4 R-HSA-180534
DNA Repair R-HSA-73894
Cellular response to chemical stress R-HSA-9711123
Signal Transduction R-HSA-162582
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Apoptosis R-HSA-109581
Signaling by Hedgehog R-HSA-5358351
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
KEAP1-NFE2L2 pathway R-HSA-9755511
Mitotic G2-G2/M phases R-HSA-453274
Axon guidance R-HSA-422475
Transcriptional regulation by RUNX3 R-HSA-8878159
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
PCP/CE pathway R-HSA-4086400
Degradation of DVL R-HSA-4641258
Degradation of AXIN R-HSA-4641257
Asymmetric localization of PCP proteins R-HSA-4608870
Synthesis of DNA R-HSA-69239
Mitotic Metaphase and Anaphase R-HSA-2555396
Hh mutants are degraded by ERAD R-HSA-5362768
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
DNA Replication R-HSA-69306
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Degradation of GLI2 by the proteasome R-HSA-5610783
C-type lectin receptors (CLRs) R-HSA-5621481
Infectious disease R-HSA-5663205
Resolution of D-Loop Structures R-HSA-5693537
Mitotic Anaphase R-HSA-68882
Transcriptional regulation by RUNX1 R-HSA-8878171
UCH proteinases R-HSA-5689603
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
p53-Independent DNA Damage Response R-HSA-69610
Hh mutants abrogate ligand secretion R-HSA-5387390
RNA Polymerase II Transcription R-HSA-73857
Nuclear events mediated by NFE2L2 R-HSA-9759194
Degradation of beta-catenin by the destruction complex R-HSA-195253
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Homology Directed Repair R-HSA-5693538
Defective CFTR causes cystic fibrosis R-HSA-5678895
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Immune System R-HSA-168256
Regulation of RUNX2 expression and activity R-HSA-8939902
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Hedgehog 'off' state R-HSA-5610787
Disorders of transmembrane transporters R-HSA-5619115
Regulation of PTEN stability and activity R-HSA-8948751
Signaling by NOTCH4 R-HSA-9013694
M Phase R-HSA-68886
Cellular responses to stress R-HSA-2262752
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Programmed Cell Death R-HSA-5357801
Nervous system development R-HSA-9675108
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Beta-catenin independent WNT signaling R-HSA-3858494
Metabolism of proteins R-HSA-392499
Ub-specific processing proteases R-HSA-5689880
Stabilization of p53 R-HSA-69541
ABC transporter disorders R-HSA-5619084
Interleukin-1 signaling R-HSA-9020702
Metabolism R-HSA-1430728
Separation of Sister Chromatids R-HSA-2467813
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
PIP3 activates AKT signaling R-HSA-1257604
Hedgehog 'on' state R-HSA-5632684
S Phase R-HSA-69242
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Vif-mediated degradation of APOBEC3G R-HSA-180585
G2/M Checkpoints R-HSA-69481
PCP/CE pathway R-HSA-4086400
p53-Independent DNA Damage Response R-HSA-69610
Metabolism R-HSA-1430728
Diseases of DNA repair R-HSA-9675135
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Interleukin-1 signaling R-HSA-9020702
DNA Replication Pre-Initiation R-HSA-69002
MAPK1/MAPK3 signaling R-HSA-5684996
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Gene expression (Transcription) R-HSA-74160
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Interleukin-1 family signaling R-HSA-446652
DNA Double-Strand Break Repair R-HSA-5693532
Signaling by Interleukins R-HSA-449147
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Degradation of GLI1 by the proteasome R-HSA-5610780
Adaptive Immune System R-HSA-1280218
Mitotic Anaphase R-HSA-68882
Signaling by Hedgehog R-HSA-5358351
Cellular response to chemical stress R-HSA-9711123
Signal Transduction R-HSA-162582
Post-translational protein modification R-HSA-597592
Degradation of GLI2 by the proteasome R-HSA-5610783
Antigen processing-Cross presentation R-HSA-1236975
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Infectious disease R-HSA-5663205
Regulation of Apoptosis R-HSA-169911
FCERI mediated NF-kB activation R-HSA-2871837
Hedgehog 'on' state R-HSA-5632684
Hedgehog 'off' state R-HSA-5610787
HIV Infection R-HSA-162906
p53-Dependent G1 DNA Damage Response R-HSA-69563
Disorders of transmembrane transporters R-HSA-5619115
Neddylation R-HSA-8951664
Regulation of RUNX3 expression and activity R-HSA-8941858
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Cell Cycle R-HSA-1640170
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
Mitotic G1 phase and G1/S transition R-HSA-453279
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Transcriptional regulation by RUNX2 R-HSA-8878166
PTEN Regulation R-HSA-6807070
Axon guidance R-HSA-422475
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Host Interactions of HIV factors R-HSA-162909
Separation of Sister Chromatids R-HSA-2467813
Cyclin E associated events during G1/S transition R-HSA-69202
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
KEAP1-NFE2L2 pathway R-HSA-9755511
Class I MHC mediated antigen processing & presentation R-HSA-983169
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Signaling by the B Cell Receptor (BCR) R-HSA-983705
G1/S DNA Damage Checkpoints R-HSA-69615
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Synthesis of DNA R-HSA-69239
UCH proteinases R-HSA-5689603
TCF dependent signaling in response to WNT R-HSA-201681
Downstream TCR signaling R-HSA-202424
Apoptosis R-HSA-109581
Disease R-HSA-1643685
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Innate Immune System R-HSA-168249
Activation of NF-kappaB in B cells R-HSA-1169091
Cellular responses to stress R-HSA-2262752
Nervous system development R-HSA-9675108
Transport of small molecules R-HSA-382551
Degradation of DVL R-HSA-4641258
Nuclear events mediated by NFE2L2 R-HSA-9759194
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Mitotic G2-G2/M phases R-HSA-453274
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Vpu mediated degradation of CD4 R-HSA-180534
Assembly of the pre-replicative complex R-HSA-68867
DNA Replication R-HSA-69306
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
RNA Polymerase II Transcription R-HSA-73857
Resolution of D-Loop Structures R-HSA-5693537
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Regulation of RAS by GAPs R-HSA-5658442
Metabolism of polyamines R-HSA-351202
Hh mutants abrogate ligand secretion R-HSA-5387390
Degradation of beta-catenin by the destruction complex R-HSA-195253
Generic Transcription Pathway R-HSA-212436
HDR through Homologous Recombination (HRR) R-HSA-5685942
G1/S Transition R-HSA-69206
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Asymmetric localization of PCP proteins R-HSA-4608870
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Metabolism of amino acids and derivatives R-HSA-71291
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Homology Directed Repair R-HSA-5693538
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
ABC-family proteins mediated transport R-HSA-382556
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Metabolism of proteins R-HSA-392499
Programmed Cell Death R-HSA-5357801
Vif-mediated degradation of APOBEC3G R-HSA-180585
Cell Cycle, Mitotic R-HSA-69278
Regulation of mitotic cell cycle R-HSA-453276
ABC transporter disorders R-HSA-5619084
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Hedgehog ligand biogenesis R-HSA-5358346
MAPK6/MAPK4 signaling R-HSA-5687128
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Defective CFTR causes cystic fibrosis R-HSA-5678895
Cellular responses to stimuli R-HSA-8953897
C-type lectin receptors (CLRs) R-HSA-5621481
Cytokine Signaling in Immune system R-HSA-1280215
ER-Phagosome pathway R-HSA-1236974
MAPK family signaling cascades R-HSA-5683057
Negative regulation of NOTCH4 signaling R-HSA-9604323
Deubiquitination R-HSA-5688426
Stabilization of p53 R-HSA-69541
Mitotic Metaphase and Anaphase R-HSA-2555396
CLEC7A (Dectin-1) signaling R-HSA-5607764
PIP3 activates AKT signaling R-HSA-1257604
Hh mutants are degraded by ERAD R-HSA-5362768
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Intracellular signaling by second messengers R-HSA-9006925
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Signaling by NOTCH4 R-HSA-9013694
Signaling by ROBO receptors R-HSA-376176
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
M Phase R-HSA-68886
Cell Cycle Checkpoints R-HSA-69620
Regulation of RUNX2 expression and activity R-HSA-8939902
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Metabolism of RNA R-HSA-8953854
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Developmental Biology R-HSA-1266738
Transcriptional regulation by RUNX3 R-HSA-8878159
Immune System R-HSA-168256
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
Degradation of AXIN R-HSA-4641257
S Phase R-HSA-69242
Ub-specific processing proteases R-HSA-5689880
DNA Repair R-HSA-73894
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
NIK-->noncanonical NF-kB signaling R-HSA-5676590
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
Signaling by WNT R-HSA-195721
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
RAF/MAP kinase cascade R-HSA-5673001
Switching of origins to a post-replicative state R-HSA-69052
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
G2/M Transition R-HSA-69275
TCR signaling R-HSA-202403
Cellular response to hypoxia R-HSA-1234174
Signaling by NOTCH R-HSA-157118
Regulation of PTEN stability and activity R-HSA-8948751
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Beta-catenin independent WNT signaling R-HSA-3858494
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Orc1 removal from chromatin R-HSA-68949
Transcriptional regulation by RUNX1 R-HSA-8878171
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
PTEN Regulation R-HSA-6807070
Apoptosis R-HSA-109581
Cytokine Signaling in Immune system R-HSA-1280215
Mitotic G1 phase and G1/S transition R-HSA-453279
C-type lectin receptors (CLRs) R-HSA-5621481
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Separation of Sister Chromatids R-HSA-2467813
Activation of NF-kappaB in B cells R-HSA-1169091
Innate Immune System R-HSA-168249
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Interleukin-1 signaling R-HSA-9020702
Gene expression (Transcription) R-HSA-74160
G2/M Transition R-HSA-69275
HIV Infection R-HSA-162906
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Transport of small molecules R-HSA-382551
Cellular response to hypoxia R-HSA-1234174
DNA Replication Pre-Initiation R-HSA-69002
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Host Interactions of HIV factors R-HSA-162909
Stabilization of p53 R-HSA-69541
Cellular response to chemical stress R-HSA-9711123
Metabolism of RNA R-HSA-8953854
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Deubiquitination R-HSA-5688426
Infectious disease R-HSA-5663205
FCERI mediated NF-kB activation R-HSA-2871837
KEAP1-NFE2L2 pathway R-HSA-9755511
Ub-specific processing proteases R-HSA-5689880
DNA Double-Strand Break Repair R-HSA-5693532
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Vif-mediated degradation of APOBEC3G R-HSA-180585
Signaling by Interleukins R-HSA-449147
Cellular responses to stress R-HSA-2262752
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Post-translational protein modification R-HSA-597592
CLEC7A (Dectin-1) signaling R-HSA-5607764
Orc1 removal from chromatin R-HSA-68949
Homology Directed Repair R-HSA-5693538
PCP/CE pathway R-HSA-4086400
Vpu mediated degradation of CD4 R-HSA-180534
Class I MHC mediated antigen processing & presentation R-HSA-983169
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Mitotic Metaphase and Anaphase R-HSA-2555396
p53-Dependent G1 DNA Damage Response R-HSA-69563
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
ABC transporter disorders R-HSA-5619084
Signaling by NOTCH R-HSA-157118
Signaling by NOTCH4 R-HSA-9013694
Disease R-HSA-1643685
Immune System R-HSA-168256
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Metabolism of amino acids and derivatives R-HSA-71291
Regulation of RUNX2 expression and activity R-HSA-8939902
Transcriptional regulation by RUNX2 R-HSA-8878166
Degradation of DVL R-HSA-4641258
Degradation of AXIN R-HSA-4641257
Downstream TCR signaling R-HSA-202424
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Developmental Biology R-HSA-1266738
Signaling by WNT R-HSA-195721
M Phase R-HSA-68886
Mitotic G2-G2/M phases R-HSA-453274
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Generic Transcription Pathway R-HSA-212436
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Cell Cycle Checkpoints R-HSA-69620
TCF dependent signaling in response to WNT R-HSA-201681
Hh mutants are degraded by ERAD R-HSA-5362768
Hedgehog 'on' state R-HSA-5632684
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Disorders of transmembrane transporters R-HSA-5619115
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Synthesis of DNA R-HSA-69239
Resolution of D-Loop Structures R-HSA-5693537
Axon guidance R-HSA-422475
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
Cell Cycle, Mitotic R-HSA-69278
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
MAPK family signaling cascades R-HSA-5683057
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Intracellular signaling by second messengers R-HSA-9006925
G2/M Checkpoints R-HSA-69481
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Mitotic Anaphase R-HSA-68882
p53-Independent DNA Damage Response R-HSA-69610
Degradation of GLI1 by the proteasome R-HSA-5610780
Regulation of PTEN stability and activity R-HSA-8948751
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
Programmed Cell Death R-HSA-5357801
Degradation of GLI2 by the proteasome R-HSA-5610783
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Transcriptional regulation by RUNX3 R-HSA-8878159
DNA Repair R-HSA-73894
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Nuclear events mediated by NFE2L2 R-HSA-9759194
Hh mutants abrogate ligand secretion R-HSA-5387390
Regulation of RUNX3 expression and activity R-HSA-8941858
Signal Transduction R-HSA-162582
G1/S Transition R-HSA-69206
Beta-catenin independent WNT signaling R-HSA-3858494
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Switching of origins to a post-replicative state R-HSA-69052
ER-Phagosome pathway R-HSA-1236974
Antigen processing-Cross presentation R-HSA-1236975
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
NIK-->noncanonical NF-kB signaling R-HSA-5676590
PIP3 activates AKT signaling R-HSA-1257604
Regulation of Apoptosis R-HSA-169911
Metabolism of proteins R-HSA-392499
Signaling by Hedgehog R-HSA-5358351
S Phase R-HSA-69242
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Metabolism of polyamines R-HSA-351202
Diseases of DNA repair R-HSA-9675135
Cyclin E associated events during G1/S transition R-HSA-69202
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
DNA Replication R-HSA-69306
MAPK6/MAPK4 signaling R-HSA-5687128
MAPK1/MAPK3 signaling R-HSA-5684996
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Neddylation R-HSA-8951664
UCH proteinases R-HSA-5689603
G1/S DNA Damage Checkpoints R-HSA-69615
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
TCR signaling R-HSA-202403
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Cellular responses to stimuli R-HSA-8953897
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
Assembly of the pre-replicative complex R-HSA-68867
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Degradation of beta-catenin by the destruction complex R-HSA-195253
Regulation of mitotic cell cycle R-HSA-453276
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Signaling by ROBO receptors R-HSA-376176
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
RAF/MAP kinase cascade R-HSA-5673001
Regulation of RAS by GAPs R-HSA-5658442
Defective CFTR causes cystic fibrosis R-HSA-5678895
Transcriptional regulation by RUNX1 R-HSA-8878171
Hedgehog 'off' state R-HSA-5610787
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Negative regulation of NOTCH4 signaling R-HSA-9604323
HDR through Homologous Recombination (HRR) R-HSA-5685942
Asymmetric localization of PCP proteins R-HSA-4608870
Interleukin-1 family signaling R-HSA-446652
Cell Cycle R-HSA-1640170
ABC-family proteins mediated transport R-HSA-382556
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Adaptive Immune System R-HSA-1280218
Hedgehog ligand biogenesis R-HSA-5358346
Nervous system development R-HSA-9675108
RNA Polymerase II Transcription R-HSA-73857
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Mitotic Metaphase and Anaphase R-HSA-2555396
G2/M Checkpoints R-HSA-69481
PTEN Regulation R-HSA-6807070
Mitotic G2-G2/M phases R-HSA-453274
Separation of Sister Chromatids R-HSA-2467813
Hedgehog 'off' state R-HSA-5610787
Regulation of PTEN stability and activity R-HSA-8948751
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Innate Immune System R-HSA-168249
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Degradation of AXIN R-HSA-4641257
Beta-catenin independent WNT signaling R-HSA-3858494
Signaling by NOTCH4 R-HSA-9013694
MAPK family signaling cascades R-HSA-5683057
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
G1/S Transition R-HSA-69206
Nuclear events mediated by NFE2L2 R-HSA-9759194
UCH proteinases R-HSA-5689603
G1/S DNA Damage Checkpoints R-HSA-69615
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
Ub-specific processing proteases R-HSA-5689880
PIP3 activates AKT signaling R-HSA-1257604
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Cellular responses to stress R-HSA-2262752
Activation of NF-kappaB in B cells R-HSA-1169091
Interleukin-1 signaling R-HSA-9020702
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Transport of small molecules R-HSA-382551
Regulation of Apoptosis R-HSA-169911
Signaling by Interleukins R-HSA-449147
Mitotic G1 phase and G1/S transition R-HSA-453279
Degradation of beta-catenin by the destruction complex R-HSA-195253
Negative regulation of NOTCH4 signaling R-HSA-9604323
MAPK6/MAPK4 signaling R-HSA-5687128
Axon guidance R-HSA-422475
Gene expression (Transcription) R-HSA-74160
Immune System R-HSA-168256
Vpu mediated degradation of CD4 R-HSA-180534
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Impaired BRCA2 binding to RAD51 R-HSA-9709570
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
ABC-family proteins mediated transport R-HSA-382556
G2/M Transition R-HSA-69275
Cellular responses to stimuli R-HSA-8953897
Degradation of GLI1 by the proteasome R-HSA-5610780
Nervous system development R-HSA-9675108
Cellular response to chemical stress R-HSA-9711123
S Phase R-HSA-69242
Hedgehog 'on' state R-HSA-5632684
Class I MHC mediated antigen processing & presentation R-HSA-983169
Signaling by NOTCH R-HSA-157118
ABC transporter disorders R-HSA-5619084
Synthesis of DNA R-HSA-69239
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Stabilization of p53 R-HSA-69541
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Metabolism of RNA R-HSA-8953854
Downstream TCR signaling R-HSA-202424
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
KEAP1-NFE2L2 pathway R-HSA-9755511
Transcriptional regulation by RUNX3 R-HSA-8878159
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
RAF/MAP kinase cascade R-HSA-5673001
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Signaling by ROBO receptors R-HSA-376176
Programmed Cell Death R-HSA-5357801
Regulation of RAS by GAPs R-HSA-5658442
Intracellular signaling by second messengers R-HSA-9006925
Regulation of expression of SLITs and ROBOs R-HSA-9010553
MAPK1/MAPK3 signaling R-HSA-5684996
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Cellular response to hypoxia R-HSA-1234174
HIV Infection R-HSA-162906
CLEC7A (Dectin-1) signaling R-HSA-5607764
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
DNA Double-Strand Break Repair R-HSA-5693532
Deubiquitination R-HSA-5688426
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Defective CFTR causes cystic fibrosis R-HSA-5678895
Adaptive Immune System R-HSA-1280218
Resolution of D-Loop Structures R-HSA-5693537
Regulation of mitotic cell cycle R-HSA-453276
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Degradation of DVL R-HSA-4641258
Disorders of transmembrane transporters R-HSA-5619115
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Transcriptional regulation by RUNX2 R-HSA-8878166
Generic Transcription Pathway R-HSA-212436
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Asymmetric localization of PCP proteins R-HSA-4608870
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Interleukin-1 family signaling R-HSA-446652
DNA Replication R-HSA-69306
Orc1 removal from chromatin R-HSA-68949
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
FCERI mediated NF-kB activation R-HSA-2871837
HDR through Homologous Recombination (HRR) R-HSA-5685942
TCF dependent signaling in response to WNT R-HSA-201681
Vif-mediated degradation of APOBEC3G R-HSA-180585
DNA Replication Pre-Initiation R-HSA-69002
Host Interactions of HIV factors R-HSA-162909
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
PCP/CE pathway R-HSA-4086400
Hh mutants abrogate ligand secretion R-HSA-5387390
M Phase R-HSA-68886
Diseases of DNA repair R-HSA-9675135
Regulation of RUNX2 expression and activity R-HSA-8939902
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Metabolism of polyamines R-HSA-351202
Cytokine Signaling in Immune system R-HSA-1280215
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Metabolism of amino acids and derivatives R-HSA-71291
Hh mutants are degraded by ERAD R-HSA-5362768
Apoptosis R-HSA-109581
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Degradation of GLI2 by the proteasome R-HSA-5610783
Cell Cycle Checkpoints R-HSA-69620
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
C-type lectin receptors (CLRs) R-HSA-5621481
Neddylation R-HSA-8951664
Cell Cycle, Mitotic R-HSA-69278
TCR signaling R-HSA-202403
Infectious disease R-HSA-5663205
NIK-->noncanonical NF-kB signaling R-HSA-5676590
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Metabolism R-HSA-1430728
Mitotic Anaphase R-HSA-68882
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
ER-Phagosome pathway R-HSA-1236974
Regulation of RUNX3 expression and activity R-HSA-8941858
Transcriptional regulation by RUNX1 R-HSA-8878171
DNA Repair R-HSA-73894
Metabolism of proteins R-HSA-392499
Signaling by WNT R-HSA-195721
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Signaling by Hedgehog R-HSA-5358351
Post-translational protein modification R-HSA-597592
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
RNA Polymerase II Transcription R-HSA-73857
Assembly of the pre-replicative complex R-HSA-68867
Switching of origins to a post-replicative state R-HSA-69052
Homology Directed Repair R-HSA-5693538
Cyclin E associated events during G1/S transition R-HSA-69202
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Disease R-HSA-1643685
p53-Dependent G1 DNA Damage Response R-HSA-69563
p53-Independent DNA Damage Response R-HSA-69610
Antigen processing-Cross presentation R-HSA-1236975
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Hedgehog ligand biogenesis R-HSA-5358346
Cell Cycle R-HSA-1640170
Nervous system development R-HSA-9675108
Regulation of RUNX2 expression and activity R-HSA-8939902
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Diseases of DNA repair R-HSA-9675135
Separation of Sister Chromatids R-HSA-2467813
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
G2/M Checkpoints R-HSA-69481
Impaired BRCA2 binding to RAD51 R-HSA-9709570
ER-Phagosome pathway R-HSA-1236974
Degradation of beta-catenin by the destruction complex R-HSA-195253
Disorders of transmembrane transporters R-HSA-5619115
Regulation of RAS by GAPs R-HSA-5658442
Beta-catenin independent WNT signaling R-HSA-3858494
Deubiquitination R-HSA-5688426
HDR through Homologous Recombination (HRR) R-HSA-5685942
MAPK family signaling cascades R-HSA-5683057
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Mitotic G1 phase and G1/S transition R-HSA-453279
Hedgehog 'on' state R-HSA-5632684
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Cell Cycle Checkpoints R-HSA-69620
Signaling by WNT R-HSA-195721
M Phase R-HSA-68886
TCF dependent signaling in response to WNT R-HSA-201681
Cyclin E associated events during G1/S transition R-HSA-69202
Signaling by ROBO receptors R-HSA-376176
Ub-specific processing proteases R-HSA-5689880
Interleukin-1 family signaling R-HSA-446652
Signaling by NOTCH R-HSA-157118
Defective CFTR causes cystic fibrosis R-HSA-5678895
Mitotic Metaphase and Anaphase R-HSA-2555396
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Intracellular signaling by second messengers R-HSA-9006925
Immune System R-HSA-168256
C-type lectin receptors (CLRs) R-HSA-5621481
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Host Interactions of HIV factors R-HSA-162909
p53-Dependent G1 DNA Damage Response R-HSA-69563
Metabolism of proteins R-HSA-392499
Resolution of D-Loop Structures R-HSA-5693537
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
KEAP1-NFE2L2 pathway R-HSA-9755511
Mitotic G2-G2/M phases R-HSA-453274
Asymmetric localization of PCP proteins R-HSA-4608870
PTEN Regulation R-HSA-6807070
Generic Transcription Pathway R-HSA-212436
Degradation of GLI1 by the proteasome R-HSA-5610780
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Axon guidance R-HSA-422475
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Vpu mediated degradation of CD4 R-HSA-180534
Switching of origins to a post-replicative state R-HSA-69052
Hedgehog ligand biogenesis R-HSA-5358346
Regulation of Apoptosis R-HSA-169911
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
Downstream TCR signaling R-HSA-202424
Cellular response to hypoxia R-HSA-1234174
Cell Cycle, Mitotic R-HSA-69278
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
G1/S Transition R-HSA-69206
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
MAPK6/MAPK4 signaling R-HSA-5687128
Cellular response to chemical stress R-HSA-9711123
MAPK1/MAPK3 signaling R-HSA-5684996
Mitotic Anaphase R-HSA-68882
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
UCH proteinases R-HSA-5689603
Synthesis of DNA R-HSA-69239
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Hedgehog 'off' state R-HSA-5610787
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Regulation of mitotic cell cycle R-HSA-453276
DNA Replication R-HSA-69306
Regulation of PTEN stability and activity R-HSA-8948751
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
Antigen processing-Cross presentation R-HSA-1236975
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Metabolism of amino acids and derivatives R-HSA-71291
ABC transporter disorders R-HSA-5619084
G2/M Transition R-HSA-69275
Metabolism of polyamines R-HSA-351202
Activation of NF-kappaB in B cells R-HSA-1169091
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
Degradation of DVL R-HSA-4641258
p53-Independent DNA Damage Response R-HSA-69610
Programmed Cell Death R-HSA-5357801
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Vif-mediated degradation of APOBEC3G R-HSA-180585
Cellular responses to stress R-HSA-2262752
NIK-->noncanonical NF-kB signaling R-HSA-5676590
S Phase R-HSA-69242
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Cytokine Signaling in Immune system R-HSA-1280215
ABC-family proteins mediated transport R-HSA-382556
Metabolism R-HSA-1430728
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Signaling by Hedgehog R-HSA-5358351
Innate Immune System R-HSA-168249
Gene expression (Transcription) R-HSA-74160
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Assembly of the pre-replicative complex R-HSA-68867
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
HIV Infection R-HSA-162906
Degradation of AXIN R-HSA-4641257
CLEC7A (Dectin-1) signaling R-HSA-5607764
DNA Repair R-HSA-73894
PCP/CE pathway R-HSA-4086400
Cellular responses to stimuli R-HSA-8953897
Class I MHC mediated antigen processing & presentation R-HSA-983169
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Regulation of RUNX3 expression and activity R-HSA-8941858
RAF/MAP kinase cascade R-HSA-5673001
Signaling by Interleukins R-HSA-449147
Homology Directed Repair R-HSA-5693538
Disease R-HSA-1643685
TCR signaling R-HSA-202403
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Developmental Biology R-HSA-1266738
Infectious disease R-HSA-5663205
DNA Double-Strand Break Repair R-HSA-5693532
Hh mutants abrogate ligand secretion R-HSA-5387390
Transcriptional regulation by RUNX1 R-HSA-8878171
Transcriptional regulation by RUNX2 R-HSA-8878166
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Orc1 removal from chromatin R-HSA-68949
Adaptive Immune System R-HSA-1280218
Negative regulation of NOTCH4 signaling R-HSA-9604323
PIP3 activates AKT signaling R-HSA-1257604
Stabilization of p53 R-HSA-69541
Metabolism of RNA R-HSA-8953854
Apoptosis R-HSA-109581
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Transport of small molecules R-HSA-382551
Post-translational protein modification R-HSA-597592
DNA Replication Pre-Initiation R-HSA-69002
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
Transcriptional regulation by RUNX3 R-HSA-8878159
Degradation of GLI2 by the proteasome R-HSA-5610783
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
Neddylation R-HSA-8951664
FCERI mediated NF-kB activation R-HSA-2871837
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Interleukin-1 signaling R-HSA-9020702
G1/S DNA Damage Checkpoints R-HSA-69615
Signal Transduction R-HSA-162582
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Hh mutants are degraded by ERAD R-HSA-5362768
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Signaling by NOTCH4 R-HSA-9013694
Nuclear events mediated by NFE2L2 R-HSA-9759194
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
p53-Independent DNA Damage Response R-HSA-69610
Metabolism of polyamines R-HSA-351202
Activation of NF-kappaB in B cells R-HSA-1169091
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Hh mutants abrogate ligand secretion R-HSA-5387390
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
Cell Cycle R-HSA-1640170
Vif-mediated degradation of APOBEC3G R-HSA-180585
Post-translational protein modification R-HSA-597592
NIK-->noncanonical NF-kB signaling R-HSA-5676590
Host Interactions of HIV factors R-HSA-162909
Cell Cycle Checkpoints R-HSA-69620
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Transcriptional regulation by RUNX1 R-HSA-8878171
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Transport of small molecules R-HSA-382551
Neddylation R-HSA-8951664
Cellular responses to stimuli R-HSA-8953897
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Metabolism of proteins R-HSA-392499
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
Programmed Cell Death R-HSA-5357801
Transcriptional regulation by RUNX3 R-HSA-8878159
Generic Transcription Pathway R-HSA-212436
PCP/CE pathway R-HSA-4086400
Cyclin E associated events during G1/S transition R-HSA-69202
Defective CFTR causes cystic fibrosis R-HSA-5678895
Apoptosis R-HSA-109581
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Resolution of D-Loop Structures R-HSA-5693537
Hedgehog ligand biogenesis R-HSA-5358346
G2/M Checkpoints R-HSA-69481
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Hedgehog 'on' state R-HSA-5632684
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Orc1 removal from chromatin R-HSA-68949
Regulation of mitotic cell cycle R-HSA-453276
Innate Immune System R-HSA-168249
MAPK6/MAPK4 signaling R-HSA-5687128
Negative regulation of NOTCH4 signaling R-HSA-9604323
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Assembly of the pre-replicative complex R-HSA-68867
Degradation of GLI1 by the proteasome R-HSA-5610780
Cellular response to chemical stress R-HSA-9711123
Metabolism of amino acids and derivatives R-HSA-71291
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
Degradation of DVL R-HSA-4641258
Antigen processing-Cross presentation R-HSA-1236975
HDR through Homologous Recombination (HRR) R-HSA-5685942
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Signaling by Interleukins R-HSA-449147
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Nuclear events mediated by NFE2L2 R-HSA-9759194
PTEN Regulation R-HSA-6807070
KEAP1-NFE2L2 pathway R-HSA-9755511
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
UCH proteinases R-HSA-5689603
G1/S Transition R-HSA-69206
Regulation of Apoptosis R-HSA-169911
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
DNA Replication R-HSA-69306
RNA Polymerase II Transcription R-HSA-73857
G1/S DNA Damage Checkpoints R-HSA-69615
Deubiquitination R-HSA-5688426
Intracellular signaling by second messengers R-HSA-9006925
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Regulation of PTEN stability and activity R-HSA-8948751
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of RUNX2 expression and activity R-HSA-8939902
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Cellular responses to stress R-HSA-2262752
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Immune System R-HSA-168256
HIV Infection R-HSA-162906
Cell Cycle, Mitotic R-HSA-69278
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
DNA Double-Strand Break Repair R-HSA-5693532
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
Interleukin-1 signaling R-HSA-9020702
MAPK family signaling cascades R-HSA-5683057
Adaptive Immune System R-HSA-1280218
Mitotic G1 phase and G1/S transition R-HSA-453279
Ub-specific processing proteases R-HSA-5689880
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Regulation of RUNX3 expression and activity R-HSA-8941858
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Developmental Biology R-HSA-1266738
Mitotic Anaphase R-HSA-68882
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Disease R-HSA-1643685
RAF/MAP kinase cascade R-HSA-5673001
Beta-catenin independent WNT signaling R-HSA-3858494
DNA Replication Pre-Initiation R-HSA-69002
Diseases of DNA repair R-HSA-9675135
Signaling by ROBO receptors R-HSA-376176
Cellular response to hypoxia R-HSA-1234174
Vpu mediated degradation of CD4 R-HSA-180534
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Homology Directed Repair R-HSA-5693538
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PIP3 activates AKT signaling R-HSA-1257604
Regulation of RAS by GAPs R-HSA-5658442
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by NOTCH R-HSA-157118
Degradation of beta-catenin by the destruction complex R-HSA-195253
FCERI mediated NF-kB activation R-HSA-2871837
ER-Phagosome pathway R-HSA-1236974
Degradation of AXIN R-HSA-4641257
C-type lectin receptors (CLRs) R-HSA-5621481
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Infectious disease R-HSA-5663205
TCR signaling R-HSA-202403
Mitotic Metaphase and Anaphase R-HSA-2555396
S Phase R-HSA-69242
Class I MHC mediated antigen processing & presentation R-HSA-983169
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
DNA Repair R-HSA-73894
Transcriptional regulation by RUNX2 R-HSA-8878166
Signaling by NOTCH4 R-HSA-9013694
Hedgehog 'off' state R-HSA-5610787
Downstream TCR signaling R-HSA-202424
Gene expression (Transcription) R-HSA-74160
ABC-family proteins mediated transport R-HSA-382556
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Nervous system development R-HSA-9675108
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
CLEC7A (Dectin-1) signaling R-HSA-5607764
Stabilization of p53 R-HSA-69541
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
Disorders of transmembrane transporters R-HSA-5619115
Mitotic G2-G2/M phases R-HSA-453274
Signaling by WNT R-HSA-195721
TCF dependent signaling in response to WNT R-HSA-201681
Interleukin-1 family signaling R-HSA-446652
MAPK1/MAPK3 signaling R-HSA-5684996
Metabolism R-HSA-1430728
M Phase R-HSA-68886
G2/M Transition R-HSA-69275
Signaling by Hedgehog R-HSA-5358351
Axon guidance R-HSA-422475
Synthesis of DNA R-HSA-69239
ABC transporter disorders R-HSA-5619084
Hh mutants are degraded by ERAD R-HSA-5362768
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Metabolism of RNA R-HSA-8953854
Switching of origins to a post-replicative state R-HSA-69052
Signal Transduction R-HSA-162582
Asymmetric localization of PCP proteins R-HSA-4608870
Separation of Sister Chromatids R-HSA-2467813
p53-Dependent G1 DNA Damage Response R-HSA-69563
Cytokine Signaling in Immune system R-HSA-1280215
Degradation of GLI2 by the proteasome R-HSA-5610783
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Programmed Cell Death R-HSA-5357801
DNA Repair R-HSA-73894
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
CLEC7A (Dectin-1) signaling R-HSA-5607764
G1/S DNA Damage Checkpoints R-HSA-69615
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
Apoptosis R-HSA-109581
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
TCF dependent signaling in response to WNT R-HSA-201681
MAPK family signaling cascades R-HSA-5683057
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Post-translational protein modification R-HSA-597592
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Regulation of PTEN stability and activity R-HSA-8948751
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Cellular responses to stimuli R-HSA-8953897
Hh mutants abrogate ligand secretion R-HSA-5387390
Interleukin-1 signaling R-HSA-9020702
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Antigen processing-Cross presentation R-HSA-1236975
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
M Phase R-HSA-68886
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Regulation of RAS by GAPs R-HSA-5658442
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
Deubiquitination R-HSA-5688426
ER-Phagosome pathway R-HSA-1236974
Class I MHC mediated antigen processing & presentation R-HSA-983169
Vpu mediated degradation of CD4 R-HSA-180534
Cellular response to hypoxia R-HSA-1234174
MAPK1/MAPK3 signaling R-HSA-5684996
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Signaling by Interleukins R-HSA-449147
Degradation of AXIN R-HSA-4641257
Axon guidance R-HSA-422475
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Regulation of RUNX2 expression and activity R-HSA-8939902
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Cell Cycle R-HSA-1640170
Negative regulation of NOTCH4 signaling R-HSA-9604323
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
Degradation of GLI2 by the proteasome R-HSA-5610783
Innate Immune System R-HSA-168249
Transcriptional regulation by RUNX1 R-HSA-8878171
Transport of small molecules R-HSA-382551
Mitotic G2-G2/M phases R-HSA-453274
Diseases of DNA repair R-HSA-9675135
Infectious disease R-HSA-5663205
Regulation of expression of SLITs and ROBOs R-HSA-9010553
Transcriptional regulation by RUNX3 R-HSA-8878159
Developmental Biology R-HSA-1266738
Cellular response to chemical stress R-HSA-9711123
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
Disorders of transmembrane transporters R-HSA-5619115
C-type lectin receptors (CLRs) R-HSA-5621481
Defective CFTR causes cystic fibrosis R-HSA-5678895
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
TCR signaling R-HSA-202403
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Nuclear events mediated by NFE2L2 R-HSA-9759194
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Ub-specific processing proteases R-HSA-5689880
Signal Transduction R-HSA-162582
Switching of origins to a post-replicative state R-HSA-69052
S Phase R-HSA-69242
Metabolism of amino acids and derivatives R-HSA-71291
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
Hedgehog ligand biogenesis R-HSA-5358346
DNA Double-Strand Break Repair R-HSA-5693532
DNA Replication Pre-Initiation R-HSA-69002
NIK-->noncanonical NF-kB signaling R-HSA-5676590
HIV Infection R-HSA-162906
Generic Transcription Pathway R-HSA-212436
Metabolism of RNA R-HSA-8953854
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
Mitotic Metaphase and Anaphase R-HSA-2555396
Regulation of mitotic cell cycle R-HSA-453276
Hedgehog 'on' state R-HSA-5632684
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Intracellular signaling by second messengers R-HSA-9006925
Downstream TCR signaling R-HSA-202424
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Orc1 removal from chromatin R-HSA-68949
RAF/MAP kinase cascade R-HSA-5673001
Metabolism R-HSA-1430728
Stabilization of p53 R-HSA-69541
p53-Independent DNA Damage Response R-HSA-69610
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
PTEN Regulation R-HSA-6807070
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
G2/M Checkpoints R-HSA-69481
G2/M Transition R-HSA-69275
Mitotic G1 phase and G1/S transition R-HSA-453279
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
Signaling by the B Cell Receptor (BCR) R-HSA-983705
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
Transcriptional regulation by RUNX2 R-HSA-8878166
Assembly of the pre-replicative complex R-HSA-68867
MAPK6/MAPK4 signaling R-HSA-5687128
DNA Replication R-HSA-69306
Degradation of beta-catenin by the destruction complex R-HSA-195253
Hh mutants are degraded by ERAD R-HSA-5362768
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
Neddylation R-HSA-8951664
Degradation of DVL R-HSA-4641258
Host Interactions of HIV factors R-HSA-162909
Homology Directed Repair R-HSA-5693538
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Disease R-HSA-1643685
Interleukin-1 family signaling R-HSA-446652
Signaling by Hedgehog R-HSA-5358351
G1/S Transition R-HSA-69206
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Metabolism of proteins R-HSA-392499
Signaling by NOTCH4 R-HSA-9013694
Regulation of RUNX3 expression and activity R-HSA-8941858
PCP/CE pathway R-HSA-4086400
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Adaptive Immune System R-HSA-1280218
Activation of NF-kappaB in B cells R-HSA-1169091
p53-Dependent G1 DNA Damage Response R-HSA-69563
Cyclin E associated events during G1/S transition R-HSA-69202
Cytokine Signaling in Immune system R-HSA-1280215
Degradation of GLI1 by the proteasome R-HSA-5610780
Hedgehog 'off' state R-HSA-5610787
Cellular responses to stress R-HSA-2262752
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
UCH proteinases R-HSA-5689603
Resolution of D-Loop Structures R-HSA-5693537
Signaling by ROBO receptors R-HSA-376176
Cell Cycle Checkpoints R-HSA-69620
Signaling by WNT R-HSA-195721
Cell Cycle, Mitotic R-HSA-69278
HDR through Homologous Recombination (HRR) R-HSA-5685942
Regulation of Apoptosis R-HSA-169911
Gene expression (Transcription) R-HSA-74160
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Asymmetric localization of PCP proteins R-HSA-4608870
KEAP1-NFE2L2 pathway R-HSA-9755511
Separation of Sister Chromatids R-HSA-2467813
Immune System R-HSA-168256
Metabolism of polyamines R-HSA-351202
ABC-family proteins mediated transport R-HSA-382556
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Beta-catenin independent WNT signaling R-HSA-3858494
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
FCERI mediated NF-kB activation R-HSA-2871837
Nervous system development R-HSA-9675108
Vif-mediated degradation of APOBEC3G R-HSA-180585
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Synthesis of DNA R-HSA-69239
PIP3 activates AKT signaling R-HSA-1257604
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
ABC transporter disorders R-HSA-5619084
RNA Polymerase II Transcription R-HSA-73857
Mitotic Anaphase R-HSA-68882
Nuclear events mediated by NFE2L2 R-HSA-9759194
Signaling by Interleukins R-HSA-449147
Regulation of RAS by GAPs R-HSA-5658442
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) R-HSA-5693567
Asymmetric localization of PCP proteins R-HSA-4608870
Hedgehog 'on' state R-HSA-5632684
Metabolism of amino acids and derivatives R-HSA-71291
Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656
Defective homologous recombination repair (HRR) due to PALB2 loss of function R-HSA-9701193
Regulation of mitotic cell cycle R-HSA-453276
Disease R-HSA-1643685
Signaling by NOTCH R-HSA-157118
Cellular response to hypoxia R-HSA-1234174
DNA Replication Pre-Initiation R-HSA-69002
G1/S DNA Damage Checkpoints R-HSA-69615
Adaptive Immune System R-HSA-1280218
Generic Transcription Pathway R-HSA-212436
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 R-HSA-9762114
Separation of Sister Chromatids R-HSA-2467813
RNA Polymerase II Transcription R-HSA-73857
Homology Directed Repair R-HSA-5693538
G2/M Transition R-HSA-69275
Vif-mediated degradation of APOBEC3G R-HSA-180585
Antigen processing-Cross presentation R-HSA-1236975
Activation of NF-kappaB in B cells R-HSA-1169091
Interleukin-1 signaling R-HSA-9020702
DNA Double-Strand Break Repair R-HSA-5693532
Neddylation R-HSA-8951664
Impaired BRCA2 translocation to the nucleus R-HSA-9709275
Cellular responses to stimuli R-HSA-8953897
Signaling by WNT R-HSA-195721
Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-211733
DNA Repair R-HSA-73894
Immune System R-HSA-168256
C-type lectin receptors (CLRs) R-HSA-5621481
Diseases of DNA Double-Strand Break Repair R-HSA-9675136
Cell Cycle Checkpoints R-HSA-69620
Ub-specific processing proteases R-HSA-5689880
FCERI mediated NF-kB activation R-HSA-2871837
p53-Independent DNA Damage Response R-HSA-69610
p53-Dependent G1 DNA Damage Response R-HSA-69563
Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184
Gene expression (Transcription) R-HSA-74160
Synthesis of DNA R-HSA-69239
Degradation of GLI1 by the proteasome R-HSA-5610780
Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168
ABC-family proteins mediated transport R-HSA-382556
MAPK1/MAPK3 signaling R-HSA-5684996
Metabolism of RNA R-HSA-8953854
Resolution of D-Loop Structures R-HSA-5693537
Signaling by NOTCH4 R-HSA-9013694
Regulation of PTEN stability and activity R-HSA-8948751
MAPK family signaling cascades R-HSA-5683057
Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607761
Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693616
Regulation of RUNX2 expression and activity R-HSA-8939902
G1/S Transition R-HSA-69206
Hh mutants abrogate ligand secretion R-HSA-5387390
Impaired BRCA2 binding to SEM1 (DSS1) R-HSA-9763198
Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174084
Switching of origins to a post-replicative state R-HSA-69052
NIK-->noncanonical NF-kB signaling R-HSA-5676590
Downstream TCR signaling R-HSA-202424
The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8852276
Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693568
Transport of small molecules R-HSA-382551
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
RAF/MAP kinase cascade R-HSA-5673001
PIP3 activates AKT signaling R-HSA-1257604
Host Interactions of HIV factors R-HSA-162909
Mitotic G2-G2/M phases R-HSA-453274
Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408
APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409
Intracellular signaling by second messengers R-HSA-9006925
Transcriptional regulation by RUNX2 R-HSA-8878166
Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-349425
Regulation of RUNX3 expression and activity R-HSA-8941858
Degradation of GLI2 by the proteasome R-HSA-5610783
Regulation of Apoptosis R-HSA-169911
G2/M Checkpoints R-HSA-69481
ABC transporter disorders R-HSA-5619084
Defective homologous recombination repair (HRR) due to BRCA1 loss of function R-HSA-9701192
Cytokine Signaling in Immune system R-HSA-1280215
Class I MHC mediated antigen processing & presentation R-HSA-983169
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Beta-catenin independent WNT signaling R-HSA-3858494
Metabolism R-HSA-1430728
Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-1236978
Diseases of DNA repair R-HSA-9675135
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
S Phase R-HSA-69242
Impaired BRCA2 binding to RAD51 R-HSA-9709570
Mitotic G1 phase and G1/S transition R-HSA-453279
SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174113
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419
Cell Cycle, Mitotic R-HSA-69278
Assembly of the pre-replicative complex R-HSA-68867
Defective CFTR causes cystic fibrosis R-HSA-5678895
Disorders of transmembrane transporters R-HSA-5619115
Apoptosis R-HSA-109581
Degradation of DVL R-HSA-4641258
Orc1 removal from chromatin R-HSA-68949
RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939236
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function R-HSA-9704331
Ubiquitin-dependent degradation of Cyclin D R-HSA-75815
Hedgehog ligand biogenesis R-HSA-5358346
p53-Dependent G1/S DNA damage checkpoint R-HSA-69580
Metabolism of proteins R-HSA-392499
Cyclin E associated events during G1/S transition R-HSA-69202
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function R-HSA-9704646
Mitotic Anaphase R-HSA-68882
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814
Cellular responses to stress R-HSA-2262752
Signaling by Hedgehog R-HSA-5358351
Mitotic Metaphase and Anaphase R-HSA-2555396
Programmed Cell Death R-HSA-5357801
Axon guidance R-HSA-422475
Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531
Post-translational protein modification R-HSA-597592
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601
Signaling by the B Cell Receptor (BCR) R-HSA-983705
M Phase R-HSA-68886
CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69017
CLEC7A (Dectin-1) signaling R-HSA-5607764
TNFR2 non-canonical NF-kB pathway R-HSA-5668541
UCH proteinases R-HSA-5689603
MAPK6/MAPK4 signaling R-HSA-5687128
Degradation of AXIN R-HSA-4641257
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5693554
Cellular response to chemical stress R-HSA-9711123
Transcriptional regulation by RUNX1 R-HSA-8878171
HIV Infection R-HSA-162906
GLI3 is processed to GLI3R by the proteasome R-HSA-5610785
HDR through Homologous Recombination (HRR) R-HSA-5685942
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
KEAP1-NFE2L2 pathway R-HSA-9755511
PCP/CE pathway R-HSA-4086400
Stabilization of p53 R-HSA-69541
SCF(Skp2)-mediated degradation of p27/p21 R-HSA-187577
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Transcriptional regulation by RUNX3 R-HSA-8878159
Developmental Biology R-HSA-1266738
Hedgehog 'off' state R-HSA-5610787
DNA Replication R-HSA-69306
Hh mutants are degraded by ERAD R-HSA-5362768
Signal Transduction R-HSA-162582
Deubiquitination R-HSA-5688426
Metabolism of polyamines R-HSA-351202
Innate Immune System R-HSA-168249
TCR signaling R-HSA-202403
Degradation of beta-catenin by the destruction complex R-HSA-195253
Homologous DNA Pairing and Strand Exchange R-HSA-5693579
Regulation of ornithine decarboxylase (ODC) R-HSA-350562
ER-Phagosome pathway R-HSA-1236974
Signaling by ROBO receptors R-HSA-376176
Negative regulation of NOTCH4 signaling R-HSA-9604323
Defective homologous recombination repair (HRR) due to BRCA2 loss of function R-HSA-9701190
TCF dependent signaling in response to WNT R-HSA-201681
Vpu mediated degradation of CD4 R-HSA-180534
AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-450408
p53-Independent G1/S DNA damage checkpoint R-HSA-69613
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Cell Cycle R-HSA-1640170
Nervous system development R-HSA-9675108
Infectious disease R-HSA-5663205
Regulation of expression of SLITs and ROBOs R-HSA-9010553
APC/C:Cdc20 mediated degradation of Securin R-HSA-174154
Interleukin-1 family signaling R-HSA-446652

Expression Atlas ENSG00000127922
NCBI gene (formerly Entrezgene) 7979
GeneCards 10845
HGNC Symbol HGNC:10845
MIM gene 601285
UniProtKB Gene Name Q6ZVN7
WikiGene 7979
Gene: CA13
Ensembl ID : ENSG00000185015
Description: carbonic anhydrase 13
Gene Synonyms: CAXIII,FLJ37995,MGC59868
2 APIs:
291 Possible Orthologues:

Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029
Metabolism R-HSA-1430728
Metabolism R-HSA-1430728
Reversible hydration of carbon dioxide R-HSA-1475029

Expression Atlas ENSG00000185015
NCBI gene (formerly Entrezgene) 377677
GeneCards 14914
HGNC Symbol HGNC:14914
MIM gene 611436
UniProtKB Gene Name Q8N1Q1
WikiGene 377677
Gene: GSTP1
Ensembl ID : ENSG00000084207
Description: glutathione S-transferase pi 1
Gene Synonyms: FAEES3,GST3,GSTP
1 APIs:
172 Possible Orthologues:

Drug ADME R-HSA-9748784
Neutrophil degranulation R-HSA-6798695
Cellular response to chemical stress R-HSA-9711123
Phase II - Conjugation of compounds R-HSA-156580
Glutathione conjugation R-HSA-156590
Paracetamol ADME R-HSA-9753281
Cellular responses to stress R-HSA-2262752
Immune System R-HSA-168256
Biological oxidations R-HSA-211859
Metabolism R-HSA-1430728
Cellular responses to stimuli R-HSA-8953897
Innate Immune System R-HSA-168249
Detoxification of Reactive Oxygen Species R-HSA-3299685
Paracetamol ADME R-HSA-9753281
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Detoxification of Reactive Oxygen Species R-HSA-3299685
Phase II - Conjugation of compounds R-HSA-156580
Cellular responses to stress R-HSA-2262752
Cellular response to chemical stress R-HSA-9711123
Neutrophil degranulation R-HSA-6798695
Cellular responses to stimuli R-HSA-8953897
Biological oxidations R-HSA-211859
Metabolism R-HSA-1430728
Glutathione conjugation R-HSA-156590
Drug ADME R-HSA-9748784
Metabolism R-HSA-1430728
Detoxification of Reactive Oxygen Species R-HSA-3299685
Paracetamol ADME R-HSA-9753281
Cellular responses to stimuli R-HSA-8953897
Immune System R-HSA-168256
Drug ADME R-HSA-9748784
Neutrophil degranulation R-HSA-6798695
Cellular responses to stress R-HSA-2262752
Cellular response to chemical stress R-HSA-9711123
Innate Immune System R-HSA-168249
Phase II - Conjugation of compounds R-HSA-156580
Biological oxidations R-HSA-211859
Glutathione conjugation R-HSA-156590
Metabolism R-HSA-1430728
Detoxification of Reactive Oxygen Species R-HSA-3299685
Neutrophil degranulation R-HSA-6798695
Immune System R-HSA-168256
Phase II - Conjugation of compounds R-HSA-156580
Cellular responses to stimuli R-HSA-8953897
Glutathione conjugation R-HSA-156590
Biological oxidations R-HSA-211859
Innate Immune System R-HSA-168249
Drug ADME R-HSA-9748784
Cellular response to chemical stress R-HSA-9711123
Cellular responses to stress R-HSA-2262752
Paracetamol ADME R-HSA-9753281
Detoxification of Reactive Oxygen Species R-HSA-3299685
Phase II - Conjugation of compounds R-HSA-156580
Glutathione conjugation R-HSA-156590
Drug ADME R-HSA-9748784
Neutrophil degranulation R-HSA-6798695
Cellular responses to stimuli R-HSA-8953897
Immune System R-HSA-168256
Cellular responses to stress R-HSA-2262752
Biological oxidations R-HSA-211859
Paracetamol ADME R-HSA-9753281
Cellular response to chemical stress R-HSA-9711123
Innate Immune System R-HSA-168249
Metabolism R-HSA-1430728
Innate Immune System R-HSA-168249
Biological oxidations R-HSA-211859
Cellular responses to stress R-HSA-2262752
Immune System R-HSA-168256
Glutathione conjugation R-HSA-156590
Drug ADME R-HSA-9748784
Paracetamol ADME R-HSA-9753281
Detoxification of Reactive Oxygen Species R-HSA-3299685
Cellular responses to stimuli R-HSA-8953897
Metabolism R-HSA-1430728
Cellular response to chemical stress R-HSA-9711123
Phase II - Conjugation of compounds R-HSA-156580
Neutrophil degranulation R-HSA-6798695
Detoxification of Reactive Oxygen Species R-HSA-3299685
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249
Cellular response to chemical stress R-HSA-9711123
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Drug ADME R-HSA-9748784
Biological oxidations R-HSA-211859
Immune System R-HSA-168256
Metabolism R-HSA-1430728
Glutathione conjugation R-HSA-156590
Paracetamol ADME R-HSA-9753281
Phase II - Conjugation of compounds R-HSA-156580
Paracetamol ADME R-HSA-9753281
Glutathione conjugation R-HSA-156590
Detoxification of Reactive Oxygen Species R-HSA-3299685
Cellular responses to stress R-HSA-2262752
Cellular response to chemical stress R-HSA-9711123
Phase II - Conjugation of compounds R-HSA-156580
Biological oxidations R-HSA-211859
Innate Immune System R-HSA-168249
Cellular responses to stimuli R-HSA-8953897
Drug ADME R-HSA-9748784
Metabolism R-HSA-1430728
Immune System R-HSA-168256
Neutrophil degranulation R-HSA-6798695
Phase II - Conjugation of compounds R-HSA-156580
Detoxification of Reactive Oxygen Species R-HSA-3299685
Paracetamol ADME R-HSA-9753281
Glutathione conjugation R-HSA-156590
Biological oxidations R-HSA-211859
Drug ADME R-HSA-9748784
Immune System R-HSA-168256
Cellular responses to stress R-HSA-2262752
Cellular response to chemical stress R-HSA-9711123
Metabolism R-HSA-1430728
Cellular responses to stimuli R-HSA-8953897
Neutrophil degranulation R-HSA-6798695
Innate Immune System R-HSA-168249

Expression Atlas ENSG00000084207
LRG display in Ensembl gene LRG_723
NCBI gene (formerly Entrezgene) 2950
GeneCards 4638
HGNC Symbol HGNC:4638
MIM gene 134660
UniProtKB Gene Name V9HWE9
WikiGene 2950
Gene: EGLN2
Ensembl ID : ENSG00000269858
Description: egl-9 family hypoxia inducible factor 2
Gene Synonyms: HIFPH1,PHD1
1 APIs:
193 Possible Orthologues:

Cellular response to hypoxia R-HSA-1234174
Cellular responses to stress R-HSA-2262752
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular response to hypoxia R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular responses to stimuli R-HSA-8953897
Cellular response to hypoxia R-HSA-1234174
Cellular responses to stress R-HSA-2262752
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular responses to stimuli R-HSA-8953897
Cellular response to hypoxia R-HSA-1234174
Cellular responses to stress R-HSA-2262752
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752
Cellular response to hypoxia R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular responses to stimuli R-HSA-8953897
Cellular response to hypoxia R-HSA-1234174
Cellular responses to stress R-HSA-2262752
Cellular response to hypoxia R-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Cellular response to hypoxia R-HSA-1234174
Cellular responses to stress R-HSA-2262752
Cellular responses to stimuli R-HSA-8953897
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1234176
Cellular response to hypoxia R-HSA-1234174
Cellular responses to stimuli R-HSA-8953897
Cellular responses to stress R-HSA-2262752

Expression Atlas ENSG00000269858
NCBI gene (formerly Entrezgene) 112398
GeneCards 14660
HGNC Symbol HGNC:14660
MIM gene 606424
UniProtKB Gene Name Q96KS0
WikiGene 112398
Gene: CDK9
Ensembl ID : ENSG00000136807
Description: cyclin dependent kinase 9
Gene Synonyms: C-2K,CDC2L4,PITALRE,TAK
7 APIs:
207 Possible Orthologues:

HIV elongation arrest and recovery R-HSA-167287
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Gene expression (Transcription) R-HSA-74160
HIV Life Cycle R-HSA-162587
RNA polymerase II transcribes snRNA genes R-HSA-6807505
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
Transcriptional Regulation by TP53 R-HSA-3700989
Estrogen-dependent gene expression R-HSA-9018519
Pausing and recovery of HIV elongation R-HSA-167290
RNA Polymerase II Transcription Elongation R-HSA-75955
Late Phase of HIV Life Cycle R-HSA-162599
HIV Transcription Elongation R-HSA-167169
RNA Polymerase II Transcription R-HSA-73857
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Generic Transcription Pathway R-HSA-212436
HIV Infection R-HSA-162906
Signaling by TGF-beta Receptor Complex R-HSA-170834
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Disease R-HSA-1643685
RNA Polymerase II Pre-transcription Events R-HSA-674695
Formation of RNA Pol II elongation complex R-HSA-112382
ESR-mediated signaling R-HSA-8939211
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
Infectious disease R-HSA-5663205
Interactions of Tat with host cellular proteins R-HSA-176034
Host Interactions of HIV factors R-HSA-162909
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
Transcription of the HIV genome R-HSA-167172
Signaling by Nuclear Receptors R-HSA-9006931
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Transcriptional Regulation by TP53 R-HSA-3700989
HIV Transcription Elongation R-HSA-167169
Infectious disease R-HSA-5663205
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
HIV Infection R-HSA-162906
Signaling by TGF-beta Receptor Complex R-HSA-170834
Transcription of the HIV genome R-HSA-167172
RNA Polymerase II Transcription Elongation R-HSA-75955
Generic Transcription Pathway R-HSA-212436
ESR-mediated signaling R-HSA-8939211
HIV Life Cycle R-HSA-162587
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Estrogen-dependent gene expression R-HSA-9018519
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
Late Phase of HIV Life Cycle R-HSA-162599
RNA Polymerase II Transcription R-HSA-73857
RNA polymerase II transcribes snRNA genes R-HSA-6807505
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Formation of RNA Pol II elongation complex R-HSA-112382
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by TGFB family members R-HSA-9006936
Interactions of Tat with host cellular proteins R-HSA-176034
Pausing and recovery of HIV elongation R-HSA-167290
Disease R-HSA-1643685
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Pre-transcription Events R-HSA-674695
Signal Transduction R-HSA-162582
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
HIV elongation arrest and recovery R-HSA-167287
Host Interactions of HIV factors R-HSA-162909
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
RNA polymerase II transcribes snRNA genes R-HSA-6807505
HIV Transcription Elongation R-HSA-167169
Infectious disease R-HSA-5663205
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Gene expression (Transcription) R-HSA-74160
Transcriptional Regulation by TP53 R-HSA-3700989
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Formation of RNA Pol II elongation complex R-HSA-112382
HIV Life Cycle R-HSA-162587
Late Phase of HIV Life Cycle R-HSA-162599
Disease R-HSA-1643685
Signaling by Nuclear Receptors R-HSA-9006931
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
RNA Polymerase II Transcription R-HSA-73857
ESR-mediated signaling R-HSA-8939211
Signaling by TGFB family members R-HSA-9006936
Host Interactions of HIV factors R-HSA-162909
HIV Infection R-HSA-162906
Pausing and recovery of HIV elongation R-HSA-167290
Transcription of the HIV genome R-HSA-167172
Estrogen-dependent gene expression R-HSA-9018519
HIV elongation arrest and recovery R-HSA-167287
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Interactions of Tat with host cellular proteins R-HSA-176034
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
RNA Polymerase II Pre-transcription Events R-HSA-674695
Signaling by TGF-beta Receptor Complex R-HSA-170834
RNA Polymerase II Transcription Elongation R-HSA-75955
Generic Transcription Pathway R-HSA-212436
Signal Transduction R-HSA-162582
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
HIV Infection R-HSA-162906
Disease R-HSA-1643685
RNA Polymerase II Transcription R-HSA-73857
Interactions of Tat with host cellular proteins R-HSA-176034
HIV Transcription Elongation R-HSA-167169
HIV Life Cycle R-HSA-162587
Formation of RNA Pol II elongation complex R-HSA-112382
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Estrogen-dependent gene expression R-HSA-9018519
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
Late Phase of HIV Life Cycle R-HSA-162599
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
HIV elongation arrest and recovery R-HSA-167287
Signaling by TGFB family members R-HSA-9006936
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
RNA Polymerase II Pre-transcription Events R-HSA-674695
ESR-mediated signaling R-HSA-8939211
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Signal Transduction R-HSA-162582
Pausing and recovery of HIV elongation R-HSA-167290
RNA Polymerase II Transcription Elongation R-HSA-75955
Signaling by TGF-beta Receptor Complex R-HSA-170834
Transcriptional Regulation by TP53 R-HSA-3700989
Signaling by Nuclear Receptors R-HSA-9006931
Transcription of the HIV genome R-HSA-167172
Infectious disease R-HSA-5663205
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Host Interactions of HIV factors R-HSA-162909
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Pausing and recovery of HIV elongation R-HSA-167290
Interactions of Tat with host cellular proteins R-HSA-176034
HIV Transcription Elongation R-HSA-167169
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
HIV Life Cycle R-HSA-162587
Signaling by Nuclear Receptors R-HSA-9006931
HIV Infection R-HSA-162906
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
RNA Polymerase II Pre-transcription Events R-HSA-674695
RNA Polymerase II Transcription Elongation R-HSA-75955
Gene expression (Transcription) R-HSA-74160
Host Interactions of HIV factors R-HSA-162909
Disease R-HSA-1643685
Estrogen-dependent gene expression R-HSA-9018519
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Transcriptional Regulation by TP53 R-HSA-3700989
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
Signaling by TGF-beta Receptor Complex R-HSA-170834
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Transcription of the HIV genome R-HSA-167172
Formation of RNA Pol II elongation complex R-HSA-112382
Signaling by TGFB family members R-HSA-9006936
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
Infectious disease R-HSA-5663205
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
HIV elongation arrest and recovery R-HSA-167287
ESR-mediated signaling R-HSA-8939211
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Late Phase of HIV Life Cycle R-HSA-162599
Signal Transduction R-HSA-162582
HIV Transcription Elongation R-HSA-167169
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
Interactions of Tat with host cellular proteins R-HSA-176034
Formation of RNA Pol II elongation complex R-HSA-112382
Signaling by Nuclear Receptors R-HSA-9006931
Late Phase of HIV Life Cycle R-HSA-162599
ESR-mediated signaling R-HSA-8939211
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Signaling by TGFB family members R-HSA-9006936
Generic Transcription Pathway R-HSA-212436
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Disease R-HSA-1643685
Transcription of the HIV genome R-HSA-167172
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
RNA Polymerase II Transcription R-HSA-73857
HIV Infection R-HSA-162906
Pausing and recovery of HIV elongation R-HSA-167290
Transcriptional Regulation by TP53 R-HSA-3700989
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription Elongation R-HSA-75955
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Signal Transduction R-HSA-162582
Infectious disease R-HSA-5663205
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Estrogen-dependent gene expression R-HSA-9018519
HIV Life Cycle R-HSA-162587
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Host Interactions of HIV factors R-HSA-162909
Signaling by TGF-beta Receptor Complex R-HSA-170834
HIV elongation arrest and recovery R-HSA-167287
RNA Polymerase II Pre-transcription Events R-HSA-674695
Transcription of the HIV genome R-HSA-167172
Generic Transcription Pathway R-HSA-212436
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Transcriptional Regulation by TP53 R-HSA-3700989
Disease R-HSA-1643685
RNA Polymerase II Pre-transcription Events R-HSA-674695
Signaling by Nuclear Receptors R-HSA-9006931
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
Signal Transduction R-HSA-162582
ESR-mediated signaling R-HSA-8939211
Formation of RNA Pol II elongation complex R-HSA-112382
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Late Phase of HIV Life Cycle R-HSA-162599
RNA Polymerase II Transcription Elongation R-HSA-75955
Pausing and recovery of HIV elongation R-HSA-167290
HIV elongation arrest and recovery R-HSA-167287
Signaling by TGF-beta Receptor Complex R-HSA-170834
HIV Life Cycle R-HSA-162587
HIV Infection R-HSA-162906
Interactions of Tat with host cellular proteins R-HSA-176034
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Host Interactions of HIV factors R-HSA-162909
RNA Polymerase II Transcription R-HSA-73857
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
Estrogen-dependent gene expression R-HSA-9018519
Infectious disease R-HSA-5663205
Signaling by TGFB family members R-HSA-9006936
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
HIV Transcription Elongation R-HSA-167169
Gene expression (Transcription) R-HSA-74160
Generic Transcription Pathway R-HSA-212436
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
RNA Polymerase II Pre-transcription Events R-HSA-674695
Signaling by TGFB family members R-HSA-9006936
HIV Infection R-HSA-162906
Host Interactions of HIV factors R-HSA-162909
Signal Transduction R-HSA-162582
Formation of RNA Pol II elongation complex R-HSA-112382
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Transcriptional Regulation by TP53 R-HSA-3700989
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Estrogen-dependent gene expression R-HSA-9018519
Signaling by TGF-beta Receptor Complex R-HSA-170834
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Infectious disease R-HSA-5663205
HIV Life Cycle R-HSA-162587
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
RNA Polymerase II Transcription Elongation R-HSA-75955
RNA Polymerase II Transcription R-HSA-73857
Disease R-HSA-1643685
HIV elongation arrest and recovery R-HSA-167287
Pausing and recovery of HIV elongation R-HSA-167290
Gene expression (Transcription) R-HSA-74160
Signaling by Nuclear Receptors R-HSA-9006931
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
ESR-mediated signaling R-HSA-8939211
Transcription of the HIV genome R-HSA-167172
Interactions of Tat with host cellular proteins R-HSA-176034
HIV Transcription Elongation R-HSA-167169
Late Phase of HIV Life Cycle R-HSA-162599
Pausing and recovery of HIV elongation R-HSA-167290
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by TGFB family members R-HSA-9006936
Transcription of the HIV genome R-HSA-167172
Signaling by TGF-beta Receptor Complex R-HSA-170834
HIV Life Cycle R-HSA-162587
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
ESR-mediated signaling R-HSA-8939211
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Signal Transduction R-HSA-162582
Interactions of Tat with host cellular proteins R-HSA-176034
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
HIV Transcription Elongation R-HSA-167169
Estrogen-dependent gene expression R-HSA-9018519
RNA Polymerase II Pre-transcription Events R-HSA-674695
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Disease R-HSA-1643685
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Host Interactions of HIV factors R-HSA-162909
RNA Polymerase II Transcription R-HSA-73857
Infectious disease R-HSA-5663205
Transcriptional Regulation by TP53 R-HSA-3700989
Gene expression (Transcription) R-HSA-74160
RNA Polymerase II Transcription Elongation R-HSA-75955
Generic Transcription Pathway R-HSA-212436
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Formation of RNA Pol II elongation complex R-HSA-112382
HIV Infection R-HSA-162906
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
HIV elongation arrest and recovery R-HSA-167287
Late Phase of HIV Life Cycle R-HSA-162599
Formation of RNA Pol II elongation complex R-HSA-112382
ESR-mediated signaling R-HSA-8939211
Disease R-HSA-1643685
Pausing and recovery of HIV elongation R-HSA-167290
Generic Transcription Pathway R-HSA-212436
Signaling by TGF-beta Receptor Complex R-HSA-170834
Infectious disease R-HSA-5663205
Gene expression (Transcription) R-HSA-74160
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Signaling by Nuclear Receptors R-HSA-9006931
Late Phase of HIV Life Cycle R-HSA-162599
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
HIV Infection R-HSA-162906
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
Signaling by TGFB family members R-HSA-9006936
RNA Polymerase II Transcription R-HSA-73857
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
Transcription of the HIV genome R-HSA-167172
Estrogen-dependent gene expression R-HSA-9018519
Signal Transduction R-HSA-162582
Host Interactions of HIV factors R-HSA-162909
HIV elongation arrest and recovery R-HSA-167287
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
HIV Life Cycle R-HSA-162587
Transcriptional Regulation by TP53 R-HSA-3700989
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
RNA Polymerase II Transcription Elongation R-HSA-75955
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
HIV Transcription Elongation R-HSA-167169
Interactions of Tat with host cellular proteins R-HSA-176034
RNA Polymerase II Pre-transcription Events R-HSA-674695
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Transcriptional Regulation by TP53 R-HSA-3700989
Estrogen-dependent gene expression R-HSA-9018519
RNA Polymerase II Pre-transcription Events R-HSA-674695
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2173796
Transcription of the HIV genome R-HSA-167172
Pausing and recovery of HIV elongation R-HSA-167290
Tat-mediated HIV elongation arrest and recovery R-HSA-167243
Gene expression (Transcription) R-HSA-74160
Disease R-HSA-1643685
Generic Transcription Pathway R-HSA-212436
Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200
Host Interactions of HIV factors R-HSA-162909
Late Phase of HIV Life Cycle R-HSA-162599
Tat-mediated elongation of the HIV-1 transcript R-HSA-167246
ESR-mediated signaling R-HSA-8939211
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793
Signal Transduction R-HSA-162582
RNA polymerase II transcribes snRNA genes R-HSA-6807505
Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152
HIV elongation arrest and recovery R-HSA-167287
HIV Infection R-HSA-162906
Signaling by TGFB family members R-HSA-9006936
Pausing and recovery of Tat-mediated HIV elongation R-HSA-167238
Formation of RNA Pol II elongation complex R-HSA-112382
Signaling by TGF-beta Receptor Complex R-HSA-170834
RNA Polymerase II Transcription Elongation R-HSA-75955
RNA Polymerase II Transcription R-HSA-73857
HIV Transcription Elongation R-HSA-167169
Signaling by Nuclear Receptors R-HSA-9006931
Interactions of Tat with host cellular proteins R-HSA-176034
HIV Life Cycle R-HSA-162587
TP53 Regulates Transcription of DNA Repair Genes R-HSA-6796648
Infectious disease R-HSA-5663205

Expression Atlas ENSG00000136807
NCBI gene (formerly Entrezgene) 1025
GeneCards 1780
HGNC Symbol HGNC:1780
MIM gene 603251
UniProtKB Gene Name X6RE90
WikiGene 1025
Gene: LCK
Ensembl ID : ENSG00000182866
Description: LCK proto-oncogene, Src family tyrosine kinase
Gene Synonyms:
2 APIs:
120 Possible Orthologues:

Generation of second messenger molecules R-HSA-202433
Negative regulation of the PI3K/AKT network R-HSA-199418
Cell surface interactions at the vascular wall R-HSA-202733
Infectious disease R-HSA-5663205
Adaptive Immune System R-HSA-1280218
GPVI-mediated activation cascade R-HSA-114604
CD28 co-stimulation R-HSA-389356
Intracellular signaling by second messengers R-HSA-9006925
Platelet activation, signaling and aggregation R-HSA-76002
FLT3 signaling through SRC family kinases R-HSA-9706374
Interleukin-2 signaling R-HSA-9020558
Immune System R-HSA-168256
CD28 dependent PI3K/Akt signaling R-HSA-389357
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Host Interactions of HIV factors R-HSA-162909
RHOH GTPase cycle R-HSA-9013407
TCR signaling R-HSA-202403
Costimulation by the CD28 family R-HSA-388841
Signaling by KIT in disease R-HSA-9669938
DAP12 interactions R-HSA-2172127
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
PI3K/AKT Signaling in Cancer R-HSA-2219528
Cytokine Signaling in Immune system R-HSA-1280215
Nef and signal transduction R-HSA-164944
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
RHO GTPase cycle R-HSA-9012999
Interleukin-2 family signaling R-HSA-451927
Nef Mediated CD4 Down-regulation R-HSA-167590
Signaling by Rho GTPases R-HSA-194315
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
HIV Infection R-HSA-162906
Signal Transduction R-HSA-162582
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Interleukins R-HSA-449147
Innate Immune System R-HSA-168249
PD-1 signaling R-HSA-389948
PIP3 activates AKT signaling R-HSA-1257604
Regulation of KIT signaling R-HSA-1433559
Hemostasis R-HSA-109582
Disease R-HSA-1643685
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Downstream TCR signaling R-HSA-202424
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
CD28 dependent Vav1 pathway R-HSA-389359
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by SCF-KIT R-HSA-1433557
FLT3 Signaling R-HSA-9607240
DAP12 signaling R-HSA-2424491
CTLA4 inhibitory signaling R-HSA-389513
PECAM1 interactions R-HSA-210990
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
RHO GTPase cycle R-HSA-9012999
Nef Mediated CD4 Down-regulation R-HSA-167590
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Infectious disease R-HSA-5663205
Signaling by SCF-KIT R-HSA-1433557
PIP3 activates AKT signaling R-HSA-1257604
Immune System R-HSA-168256
Signaling by Rho GTPases R-HSA-194315
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Negative regulation of the PI3K/AKT network R-HSA-199418
PECAM1 interactions R-HSA-210990
FLT3 Signaling R-HSA-9607240
Intracellular signaling by second messengers R-HSA-9006925
Costimulation by the CD28 family R-HSA-388841
PD-1 signaling R-HSA-389948
Generation of second messenger molecules R-HSA-202433
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
RHOH GTPase cycle R-HSA-9013407
Adaptive Immune System R-HSA-1280218
Signaling by KIT in disease R-HSA-9669938
TCR signaling R-HSA-202403
DAP12 signaling R-HSA-2424491
Interleukin-2 family signaling R-HSA-451927
Innate Immune System R-HSA-168249
GPVI-mediated activation cascade R-HSA-114604
Signal Transduction R-HSA-162582
Downstream TCR signaling R-HSA-202424
CD28 dependent Vav1 pathway R-HSA-389359
Interleukin-2 signaling R-HSA-9020558
PI3K/AKT Signaling in Cancer R-HSA-2219528
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Platelet activation, signaling and aggregation R-HSA-76002
CD28 dependent PI3K/Akt signaling R-HSA-389357
CD28 co-stimulation R-HSA-389356
Hemostasis R-HSA-109582
Host Interactions of HIV factors R-HSA-162909
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Cell surface interactions at the vascular wall R-HSA-202733
Disease R-HSA-1643685
Signaling by Interleukins R-HSA-449147
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Regulation of KIT signaling R-HSA-1433559
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
HIV Infection R-HSA-162906
Nef and signal transduction R-HSA-164944
FLT3 signaling through SRC family kinases R-HSA-9706374
CTLA4 inhibitory signaling R-HSA-389513
DAP12 interactions R-HSA-2172127
CTLA4 inhibitory signaling R-HSA-389513
CD28 dependent Vav1 pathway R-HSA-389359
Host Interactions of HIV factors R-HSA-162909
GPVI-mediated activation cascade R-HSA-114604
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
DAP12 interactions R-HSA-2172127
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by KIT in disease R-HSA-9669938
Nef Mediated CD4 Down-regulation R-HSA-167590
Hemostasis R-HSA-109582
RHOH GTPase cycle R-HSA-9013407
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Signal Transduction R-HSA-162582
DAP12 signaling R-HSA-2424491
Interleukin-2 family signaling R-HSA-451927
Intracellular signaling by second messengers R-HSA-9006925
PECAM1 interactions R-HSA-210990
PD-1 signaling R-HSA-389948
Interleukin-2 signaling R-HSA-9020558
Generation of second messenger molecules R-HSA-202433
FLT3 Signaling R-HSA-9607240
RHO GTPase cycle R-HSA-9012999
Adaptive Immune System R-HSA-1280218
Nef and signal transduction R-HSA-164944
CD28 dependent PI3K/Akt signaling R-HSA-389357
Regulation of KIT signaling R-HSA-1433559
HIV Infection R-HSA-162906
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
PI3K/AKT Signaling in Cancer R-HSA-2219528
Infectious disease R-HSA-5663205
TCR signaling R-HSA-202403
Cell surface interactions at the vascular wall R-HSA-202733
Innate Immune System R-HSA-168249
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream TCR signaling R-HSA-202424
Signaling by SCF-KIT R-HSA-1433557
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PIP3 activates AKT signaling R-HSA-1257604
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Costimulation by the CD28 family R-HSA-388841
Immune System R-HSA-168256
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Interleukins R-HSA-449147
FLT3 signaling through SRC family kinases R-HSA-9706374
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Disease R-HSA-1643685
Signaling by Rho GTPases R-HSA-194315
CD28 co-stimulation R-HSA-389356
Hemostasis R-HSA-109582
Interleukin-2 signaling R-HSA-9020558
Disease R-HSA-1643685
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Nef and signal transduction R-HSA-164944
CD28 co-stimulation R-HSA-389356
PIP3 activates AKT signaling R-HSA-1257604
PI3K/AKT Signaling in Cancer R-HSA-2219528
Adaptive Immune System R-HSA-1280218
FLT3 signaling through SRC family kinases R-HSA-9706374
Signaling by SCF-KIT R-HSA-1433557
CTLA4 inhibitory signaling R-HSA-389513
Cell surface interactions at the vascular wall R-HSA-202733
HIV Infection R-HSA-162906
Platelet activation, signaling and aggregation R-HSA-76002
RHO GTPase cycle R-HSA-9012999
Costimulation by the CD28 family R-HSA-388841
Signaling by Interleukins R-HSA-449147
RHOH GTPase cycle R-HSA-9013407
GPVI-mediated activation cascade R-HSA-114604
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Immune System R-HSA-168256
CD28 dependent Vav1 pathway R-HSA-389359
Negative regulation of the PI3K/AKT network R-HSA-199418
DAP12 signaling R-HSA-2424491
PECAM1 interactions R-HSA-210990
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Downstream TCR signaling R-HSA-202424
Generation of second messenger molecules R-HSA-202433
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
TCR signaling R-HSA-202403
Regulation of KIT signaling R-HSA-1433559
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Intracellular signaling by second messengers R-HSA-9006925
Signaling by KIT in disease R-HSA-9669938
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
FLT3 Signaling R-HSA-9607240
Signaling by Rho GTPases R-HSA-194315
Host Interactions of HIV factors R-HSA-162909
Infectious disease R-HSA-5663205
Interleukin-2 family signaling R-HSA-451927
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Nef Mediated CD4 Down-regulation R-HSA-167590
PD-1 signaling R-HSA-389948
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Innate Immune System R-HSA-168249
DAP12 interactions R-HSA-2172127
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
CD28 dependent Vav1 pathway R-HSA-389359
DAP12 interactions R-HSA-2172127
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Infectious disease R-HSA-5663205
Host Interactions of HIV factors R-HSA-162909
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHO GTPase cycle R-HSA-9012999
Interleukin-2 family signaling R-HSA-451927
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Intracellular signaling by second messengers R-HSA-9006925
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Nef and signal transduction R-HSA-164944
Cell surface interactions at the vascular wall R-HSA-202733
Nef Mediated CD4 Down-regulation R-HSA-167590
PD-1 signaling R-HSA-389948
Signaling by SCF-KIT R-HSA-1433557
Innate Immune System R-HSA-168249
Immune System R-HSA-168256
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Disease R-HSA-1643685
Signaling by KIT in disease R-HSA-9669938
GPVI-mediated activation cascade R-HSA-114604
HIV Infection R-HSA-162906
RHOH GTPase cycle R-HSA-9013407
Adaptive Immune System R-HSA-1280218
Downstream TCR signaling R-HSA-202424
PIP3 activates AKT signaling R-HSA-1257604
Regulation of KIT signaling R-HSA-1433559
FLT3 signaling through SRC family kinases R-HSA-9706374
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
PI3K/AKT Signaling in Cancer R-HSA-2219528
FLT3 Signaling R-HSA-9607240
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Costimulation by the CD28 family R-HSA-388841
Platelet activation, signaling and aggregation R-HSA-76002
Hemostasis R-HSA-109582
Signaling by Interleukins R-HSA-449147
Signaling by Rho GTPases R-HSA-194315
Interleukin-2 signaling R-HSA-9020558
CTLA4 inhibitory signaling R-HSA-389513
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
CD28 dependent PI3K/Akt signaling R-HSA-389357
TCR signaling R-HSA-202403
Signal Transduction R-HSA-162582
PECAM1 interactions R-HSA-210990
Generation of second messenger molecules R-HSA-202433
Cytokine Signaling in Immune system R-HSA-1280215
DAP12 signaling R-HSA-2424491
CD28 co-stimulation R-HSA-389356
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Nef Mediated CD4 Down-regulation R-HSA-167590
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Cytokine Signaling in Immune system R-HSA-1280215
DAP12 interactions R-HSA-2172127
Nef and signal transduction R-HSA-164944
Negative regulation of the PI3K/AKT network R-HSA-199418
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
CD28 dependent PI3K/Akt signaling R-HSA-389357
GPVI-mediated activation cascade R-HSA-114604
RHO GTPase cycle R-HSA-9012999
DAP12 signaling R-HSA-2424491
TCR signaling R-HSA-202403
Signaling by Interleukins R-HSA-449147
FLT3 Signaling R-HSA-9607240
Cell surface interactions at the vascular wall R-HSA-202733
FLT3 signaling through SRC family kinases R-HSA-9706374
Adaptive Immune System R-HSA-1280218
Hemostasis R-HSA-109582
Signaling by Rho GTPases R-HSA-194315
Interleukin-2 family signaling R-HSA-451927
CD28 dependent Vav1 pathway R-HSA-389359
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
HIV Infection R-HSA-162906
Signaling by KIT in disease R-HSA-9669938
PIP3 activates AKT signaling R-HSA-1257604
Intracellular signaling by second messengers R-HSA-9006925
PI3K/AKT Signaling in Cancer R-HSA-2219528
Interleukin-2 signaling R-HSA-9020558
PD-1 signaling R-HSA-389948
Generation of second messenger molecules R-HSA-202433
CD28 co-stimulation R-HSA-389356
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
PECAM1 interactions R-HSA-210990
RHOH GTPase cycle R-HSA-9013407
Downstream TCR signaling R-HSA-202424
Host Interactions of HIV factors R-HSA-162909
Innate Immune System R-HSA-168249
Infectious disease R-HSA-5663205
Signaling by SCF-KIT R-HSA-1433557
Disease R-HSA-1643685
Costimulation by the CD28 family R-HSA-388841
CTLA4 inhibitory signaling R-HSA-389513
Immune System R-HSA-168256
Platelet activation, signaling and aggregation R-HSA-76002
Regulation of KIT signaling R-HSA-1433559
DAP12 interactions R-HSA-2172127
Costimulation by the CD28 family R-HSA-388841
Cell surface interactions at the vascular wall R-HSA-202733
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
RHO GTPase cycle R-HSA-9012999
CTLA4 inhibitory signaling R-HSA-389513
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Nef and signal transduction R-HSA-164944
Signaling by KIT in disease R-HSA-9669938
CD28 dependent PI3K/Akt signaling R-HSA-389357
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Rho GTPases R-HSA-194315
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
PD-1 signaling R-HSA-389948
Platelet activation, signaling and aggregation R-HSA-76002
Immune System R-HSA-168256
Signaling by SCF-KIT R-HSA-1433557
TCR signaling R-HSA-202403
Adaptive Immune System R-HSA-1280218
Regulation of KIT signaling R-HSA-1433559
Cytokine Signaling in Immune system R-HSA-1280215
Disease R-HSA-1643685
PI3K/AKT Signaling in Cancer R-HSA-2219528
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Infectious disease R-HSA-5663205
Signaling by Interleukins R-HSA-449147
Interleukin-2 signaling R-HSA-9020558
Signal Transduction R-HSA-162582
HIV Infection R-HSA-162906
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Hemostasis R-HSA-109582
Generation of second messenger molecules R-HSA-202433
Intracellular signaling by second messengers R-HSA-9006925
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
Interleukin-2 family signaling R-HSA-451927
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
CD28 dependent Vav1 pathway R-HSA-389359
RHOH GTPase cycle R-HSA-9013407
Innate Immune System R-HSA-168249
FLT3 Signaling R-HSA-9607240
FLT3 signaling through SRC family kinases R-HSA-9706374
GPVI-mediated activation cascade R-HSA-114604
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Downstream TCR signaling R-HSA-202424
Nef Mediated CD4 Down-regulation R-HSA-167590
Host Interactions of HIV factors R-HSA-162909
CD28 co-stimulation R-HSA-389356
DAP12 signaling R-HSA-2424491
PECAM1 interactions R-HSA-210990
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Downstream TCR signaling R-HSA-202424
GPVI-mediated activation cascade R-HSA-114604
Negative regulation of the PI3K/AKT network R-HSA-199418
Translocation of ZAP-70 to Immunological synapse R-HSA-202430
Signaling by SCF-KIT R-HSA-1433557
Signal Transduction R-HSA-162582
Innate Immune System R-HSA-168249
Hemostasis R-HSA-109582
Infectious disease R-HSA-5663205
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Generation of second messenger molecules R-HSA-202433
CD28 dependent Vav1 pathway R-HSA-389359
Interleukin-2 family signaling R-HSA-451927
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164938
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by KIT in disease R-HSA-9669938
Cytokine Signaling in Immune system R-HSA-1280215
PI3K/AKT Signaling in Cancer R-HSA-2219528
DAP12 interactions R-HSA-2172127
Intracellular signaling by second messengers R-HSA-9006925
Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530
Immune System R-HSA-168256
FLT3 signaling through SRC family kinases R-HSA-9706374
Interleukin-2 signaling R-HSA-9020558
CTLA4 inhibitory signaling R-HSA-389513
PECAM1 interactions R-HSA-210990
PIP3 activates AKT signaling R-HSA-1257604
Host Interactions of HIV factors R-HSA-162909
Adaptive Immune System R-HSA-1280218
CD28 co-stimulation R-HSA-389356
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Cell surface interactions at the vascular wall R-HSA-202733
Phosphorylation of CD3 and TCR zeta chains R-HSA-202427
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
HIV Infection R-HSA-162906
Signaling by Rho GTPases R-HSA-194315
Nef and signal transduction R-HSA-164944
Platelet activation, signaling and aggregation R-HSA-76002
Signaling by Interleukins R-HSA-449147
Costimulation by the CD28 family R-HSA-388841
Disease R-HSA-1643685
CD28 dependent PI3K/Akt signaling R-HSA-389357
Nef Mediated CD4 Down-regulation R-HSA-167590
FLT3 Signaling R-HSA-9607240
Regulation of KIT signaling R-HSA-1433559
The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-164952
RHO GTPase cycle R-HSA-9012999
PD-1 signaling R-HSA-389948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RHOH GTPase cycle R-HSA-9013407
TCR signaling R-HSA-202403
DAP12 signaling R-HSA-2424491

Expression Atlas ENSG00000182866
LRG display in Ensembl gene LRG_153
NCBI gene (formerly Entrezgene) 3932
GeneCards 6524
HGNC Symbol HGNC:6524
MIM gene 153390
MIM morbid 615758
UniProtKB Gene Name P06239
WikiGene 3932
Gene: INSR
Ensembl ID : ENSG00000171105
Description: insulin receptor
Gene Synonyms: CD220
36 APIs:
290 Possible Orthologues:

Signaling by Insulin receptor R-HSA-74752
PIP3 activates AKT signaling R-HSA-1257604
IRS activation R-HSA-74713
Signal attenuation R-HSA-74749
Insulin receptor recycling R-HSA-77387
Insulin receptor signalling cascade R-HSA-74751
Signal Transduction R-HSA-162582
Negative regulation of the PI3K/AKT network R-HSA-199418
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor recycling R-HSA-77387
IRS activation R-HSA-74713
Signaling by Insulin receptor R-HSA-74752
Intracellular signaling by second messengers R-HSA-9006925
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
Negative regulation of the PI3K/AKT network R-HSA-199418
PIP3 activates AKT signaling R-HSA-1257604
Signal attenuation R-HSA-74749
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Insulin receptor signalling cascade R-HSA-74751
Signaling by Insulin receptor R-HSA-74752
Signal Transduction R-HSA-162582
Insulin receptor recycling R-HSA-77387
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal attenuation R-HSA-74749
Intracellular signaling by second messengers R-HSA-9006925
PIP3 activates AKT signaling R-HSA-1257604
Negative regulation of the PI3K/AKT network R-HSA-199418
IRS activation R-HSA-74713
Insulin receptor signalling cascade R-HSA-74751
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
Signaling by Insulin receptor R-HSA-74752
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor signalling cascade R-HSA-74751
IRS activation R-HSA-74713
Negative regulation of the PI3K/AKT network R-HSA-199418
Insulin receptor recycling R-HSA-77387
Signal attenuation R-HSA-74749
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
PIP3 activates AKT signaling R-HSA-1257604
Insulin receptor recycling R-HSA-77387
Signal attenuation R-HSA-74749
Insulin receptor signalling cascade R-HSA-74751
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by Insulin receptor R-HSA-74752
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal Transduction R-HSA-162582
Intracellular signaling by second messengers R-HSA-9006925
Negative regulation of the PI3K/AKT network R-HSA-199418
PIP3 activates AKT signaling R-HSA-1257604
IRS activation R-HSA-74713
IRS activation R-HSA-74713
Signal Transduction R-HSA-162582
Insulin receptor signalling cascade R-HSA-74751
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Intracellular signaling by second messengers R-HSA-9006925
Signaling by Insulin receptor R-HSA-74752
Insulin receptor recycling R-HSA-77387
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal attenuation R-HSA-74749
PIP3 activates AKT signaling R-HSA-1257604
Insulin receptor signalling cascade R-HSA-74751
Signal attenuation R-HSA-74749
Negative regulation of the PI3K/AKT network R-HSA-199418
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signal Transduction R-HSA-162582
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
IRS activation R-HSA-74713
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Insulin receptor R-HSA-74752
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor recycling R-HSA-77387
Negative regulation of the PI3K/AKT network R-HSA-199418
Intracellular signaling by second messengers R-HSA-9006925
Insulin receptor signalling cascade R-HSA-74751
Signal Transduction R-HSA-162582
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
Signal attenuation R-HSA-74749
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
IRS activation R-HSA-74713
PIP3 activates AKT signaling R-HSA-1257604
Signaling by Insulin receptor R-HSA-74752
Insulin receptor recycling R-HSA-77387
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of the PI3K/AKT network R-HSA-199418
Signal attenuation R-HSA-74749
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-6811558
PIP3 activates AKT signaling R-HSA-1257604
Insulin receptor signalling cascade R-HSA-74751
Intracellular signaling by second messengers R-HSA-9006925
Signal Transduction R-HSA-162582
Insulin receptor recycling R-HSA-77387
IRS activation R-HSA-74713
Signaling by Insulin receptor R-HSA-74752

Expression Atlas ENSG00000171105
NCBI gene (formerly Entrezgene) 3643
GeneCards 6091
HGNC Symbol HGNC:6091
MIM gene 147670
MIM morbid 610549
UniProtKB Gene Name P06213
WikiGene 3643
Gene: SI
Ensembl ID : ENSG00000090402
Description: sucrase-isomaltase
Gene Synonyms:
2 APIs:
201 Possible Orthologues:

Digestion and absorption R-HSA-8963743
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Diseases of metabolism R-HSA-5668914
Diseases of carbohydrate metabolism R-HSA-5663084
Disease R-HSA-1643685
Intestinal saccharidase deficiencies R-HSA-5659898
Digestion and absorption R-HSA-8963743
Intestinal saccharidase deficiencies R-HSA-5659898
Disease R-HSA-1643685
Diseases of carbohydrate metabolism R-HSA-5663084
Diseases of metabolism R-HSA-5668914
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Digestion of dietary carbohydrate R-HSA-189085
Disease R-HSA-1643685
Diseases of carbohydrate metabolism R-HSA-5663084
Digestion R-HSA-8935690
Intestinal saccharidase deficiencies R-HSA-5659898
Digestion and absorption R-HSA-8963743
Diseases of metabolism R-HSA-5668914
Digestion and absorption R-HSA-8963743
Intestinal saccharidase deficiencies R-HSA-5659898
Digestion R-HSA-8935690
Diseases of carbohydrate metabolism R-HSA-5663084
Diseases of metabolism R-HSA-5668914
Digestion of dietary carbohydrate R-HSA-189085
Disease R-HSA-1643685
Intestinal saccharidase deficiencies R-HSA-5659898
Disease R-HSA-1643685
Digestion and absorption R-HSA-8963743
Diseases of carbohydrate metabolism R-HSA-5663084
Diseases of metabolism R-HSA-5668914
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Intestinal saccharidase deficiencies R-HSA-5659898
Diseases of carbohydrate metabolism R-HSA-5663084
Disease R-HSA-1643685
Digestion and absorption R-HSA-8963743
Diseases of metabolism R-HSA-5668914
Disease R-HSA-1643685
Diseases of metabolism R-HSA-5668914
Digestion R-HSA-8935690
Digestion of dietary carbohydrate R-HSA-189085
Digestion and absorption R-HSA-8963743
Diseases of carbohydrate metabolism R-HSA-5663084
Intestinal saccharidase deficiencies R-HSA-5659898

Expression Atlas ENSG00000090402
NCBI gene (formerly Entrezgene) 6476
GeneCards 10856
HGNC Symbol HGNC:10856
MIM gene 609845
MIM morbid 222900
UniProtKB Gene Name P14410
WikiGene 6476