Gene: KRAS
Ensembl ID : ENSG00000133703
Description: KRAS proto-oncogene, GTPase
Gene Synonyms: K-RAS4B,KRAS1,KRAS2
2 APIs:
204 Possible Orthologues:

Signaling by EGFR R-HSA-177929
p38MAPK events R-HSA-171007
Signaling by WNT R-HSA-195721
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by RAS GTPase mutants R-HSA-9753512
Signaling downstream of RAS mutants R-HSA-9649948
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Downstream signaling of activated FGFR2 R-HSA-5654696
Insulin receptor signalling cascade R-HSA-74751
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Immune System R-HSA-168256
FCERI mediated MAPK activation R-HSA-2871796
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Signaling by ERBB4 R-HSA-1236394
Signaling by FGFR2 in disease R-HSA-5655253
Signaling by FGFR2 R-HSA-5654738
SHC-mediated cascade:FGFR3 R-HSA-5654704
SOS-mediated signalling R-HSA-112412
SHC-mediated cascade:FGFR1 R-HSA-5654688
Axon guidance R-HSA-422475
Signaling by ERBB2 R-HSA-1227986
DAP12 interactions R-HSA-2172127
Tie2 Signaling R-HSA-210993
SHC1 events in ERBB2 signaling R-HSA-1250196
G alpha (q) signalling events R-HSA-416476
Signaling by NTRKs R-HSA-166520
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by FLT3 fusion proteins R-HSA-9703465
Disease R-HSA-1643685
Extra-nuclear estrogen signaling R-HSA-9009391
ESR-mediated signaling R-HSA-8939211
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by FGFR4 R-HSA-5654743
Signaling by PDGF R-HSA-186797
RAS GTPase cycle mutants R-HSA-9649913
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by WNT R-HSA-195721
IGF1R signaling cascade R-HSA-2428924
Signaling by FGFR3 in disease R-HSA-5655332
Signaling by SCF-KIT R-HSA-1433557
Regulation of RAS by GAPs R-HSA-5658442
Hemostasis R-HSA-109582
IRS-mediated signalling R-HSA-112399
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by GPCR R-HSA-372790
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by EGFRvIII in Cancer R-HSA-5637812
CD209 (DC-SIGN) signaling R-HSA-5621575
SHC-mediated cascade:FGFR4 R-HSA-5654719
Downstream signal transduction R-HSA-186763
Signaling by Erythropoietin R-HSA-9006335
FLT3 Signaling R-HSA-9607240
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by CSF3 (G-CSF) R-HSA-9674555
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by PTK6 R-HSA-8848021
Downstream signaling of activated FGFR3 R-HSA-5654708
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
RAS processing R-HSA-9648002
Ca2+ pathway R-HSA-4086398
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Innate Immune System R-HSA-168249
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
SHC-mediated cascade:FGFR2 R-HSA-5654699
Signaling by FGFR in disease R-HSA-1226099
Activation of RAS in B cells R-HSA-1169092
Signaling by FGFR1 R-HSA-5654736
RUNX3 regulates p14-ARF R-HSA-8951936
Neuronal System R-HSA-112316
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
IRS-related events triggered by IGF1R R-HSA-2428928
Activated NTRK2 signals through RAS R-HSA-9026519
Signaling by KIT in disease R-HSA-9669938
Signaling by VEGF R-HSA-194138
Erythropoietin activates RAS R-HSA-9027284
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by RAF1 mutants R-HSA-9656223
Signaling by RAS mutants R-HSA-6802949
Beta-catenin independent WNT signaling R-HSA-3858494
Oncogenic MAPK signaling R-HSA-6802957
Signaling by NTRK2 (TRKB) R-HSA-9006115
FLT3 signaling in disease R-HSA-9682385
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
RNA Polymerase II Transcription R-HSA-73857
Signaling by FGFR R-HSA-190236
p38MAPK events R-HSA-171007
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Adaptive Immune System R-HSA-1280218
Signaling by RAS GAP mutants R-HSA-9753510
MET activates RAS signaling R-HSA-8851805
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
SHC-related events triggered by IGF1R R-HSA-2428933
Signalling to RAS R-HSA-167044
VEGFA-VEGFR2 Pathway R-HSA-4420097
FRS-mediated FGFR4 signaling R-HSA-5654712
MAPK1/MAPK3 signaling R-HSA-5684996
Signal Transduction R-HSA-162582
Signaling by FGFR1 in disease R-HSA-5655302
GRB2 events in ERBB2 signaling R-HSA-1963640
GRB2 events in EGFR signaling R-HSA-179812
MAP2K and MAPK activation R-HSA-5674135
Activated NTRK3 signals through RAS R-HSA-9034864
Generic Transcription Pathway R-HSA-212436
Cell surface interactions at the vascular wall R-HSA-202733
Negative regulation of MAPK pathway R-HSA-5675221
NCAM signaling for neurite out-growth R-HSA-375165
DAP12 signaling R-HSA-2424491
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Transcriptional regulation by RUNX3 R-HSA-8878159
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
FRS-mediated FGFR1 signaling R-HSA-5654693
RAF activation R-HSA-5673000
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by PDGFR in disease R-HSA-9671555
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR3 R-HSA-5654741
Post NMDA receptor activation events R-HSA-438064
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signalling to ERKs R-HSA-187687
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by Nuclear Receptors R-HSA-9006931
Gene expression (Transcription) R-HSA-74160
Signaling by EGFR in Cancer R-HSA-1643713
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by the B Cell Receptor (BCR) R-HSA-983705
VEGFR2 mediated cell proliferation R-HSA-5218921
GPCR downstream signalling R-HSA-388396
Developmental Biology R-HSA-1266738
Signaling by MET R-HSA-6806834
Nervous system development R-HSA-9675108
Signaling by EGFR R-HSA-177929
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transmission across Chemical Synapses R-HSA-112315
Constitutive Signaling by EGFRvIII R-HSA-5637810
SHC1 events in EGFR signaling R-HSA-180336
Signaling by Insulin receptor R-HSA-74752
RAF/MAP kinase cascade R-HSA-5673001
Signaling by EGFR R-HSA-177929
EGFR Transactivation by Gastrin R-HSA-2179392
DAP12 signaling R-HSA-2424491
Insulin receptor signalling cascade R-HSA-74751
Signaling by PTK6 R-HSA-8848021
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Downstream signaling of activated FGFR4 R-HSA-5654716
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by ERBB2 in Cancer R-HSA-1227990
RAF/MAP kinase cascade R-HSA-5673001
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by WNT R-HSA-195721
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by RAS GTPase mutants R-HSA-9753512
G alpha (q) signalling events R-HSA-416476
Signaling by PDGFR in disease R-HSA-9671555
ESR-mediated signaling R-HSA-8939211
Signal Transduction R-HSA-162582
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Nervous system development R-HSA-9675108
RUNX3 regulates p14-ARF R-HSA-8951936
Signaling by FGFR4 in disease R-HSA-5655291
Post NMDA receptor activation events R-HSA-438064
Signaling by ERBB4 R-HSA-1236394
IGF1R signaling cascade R-HSA-2428924
Signaling by Nuclear Receptors R-HSA-9006931
Ca2+ pathway R-HSA-4086398
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
VEGFA-VEGFR2 Pathway R-HSA-4420097
Adaptive Immune System R-HSA-1280218
Signaling by FGFR R-HSA-190236
Signaling by Insulin receptor R-HSA-74752
FCERI mediated MAPK activation R-HSA-2871796
FLT3 Signaling R-HSA-9607240
Neuronal System R-HSA-112316
Disease R-HSA-1643685
SOS-mediated signalling R-HSA-112412
CD209 (DC-SIGN) signaling R-HSA-5621575
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by KIT in disease R-HSA-9669938
RAF activation R-HSA-5673000
RNA Polymerase II Transcription R-HSA-73857
Signaling by FGFR in disease R-HSA-1226099
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Regulation of RAS by GAPs R-HSA-5658442
Tie2 Signaling R-HSA-210993
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
Innate Immune System R-HSA-168249
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by FGFR2 R-HSA-5654738
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by PDGF R-HSA-186797
Transmission across Chemical Synapses R-HSA-112315
Hemostasis R-HSA-109582
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by GPCR R-HSA-372790
SHC1 events in ERBB2 signaling R-HSA-1250196
Erythropoietin activates RAS R-HSA-9027284
Signaling by ERBB2 KD Mutants R-HSA-9664565
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
FRS-mediated FGFR3 signaling R-HSA-5654706
FRS-mediated FGFR4 signaling R-HSA-5654712
Axon guidance R-HSA-422475
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by EGFRvIII in Cancer R-HSA-5637812
p38MAPK events R-HSA-171007
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by ERBB2 ECD mutants R-HSA-9665348
SHC-mediated cascade:FGFR2 R-HSA-5654699
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by FGFR4 R-HSA-5654743
Downstream signaling of activated FGFR2 R-HSA-5654696
Activated NTRK2 signals through RAS R-HSA-9026519
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
SHC-mediated cascade:FGFR4 R-HSA-5654719
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by SCF-KIT R-HSA-1433557
Signaling by FGFR3 R-HSA-5654741
IRS-mediated signalling R-HSA-112399
Immune System R-HSA-168256
Developmental Biology R-HSA-1266738
Signaling by MET R-HSA-6806834
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by ERBB2 R-HSA-1227986
Signaling by NTRK2 (TRKB) R-HSA-9006115
Downstream signaling of activated FGFR1 R-HSA-5654687
MET activates RAS signaling R-HSA-8851805
GRB2 events in EGFR signaling R-HSA-179812
SHC-mediated cascade:FGFR3 R-HSA-5654704
Cytokine Signaling in Immune system R-HSA-1280215
FRS-mediated FGFR2 signaling R-HSA-5654700
MAPK family signaling cascades R-HSA-5683057
Signaling by RAS mutants R-HSA-6802949
Gene expression (Transcription) R-HSA-74160
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
FLT3 signaling in disease R-HSA-9682385
Signaling by RAF1 mutants R-HSA-9656223
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by FGFR2 in disease R-HSA-5655253
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
SHC-mediated cascade:FGFR1 R-HSA-5654688
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by VEGF R-HSA-194138
Signaling by FGFR1 in disease R-HSA-5655302
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by FGFR1 R-HSA-5654736
Generic Transcription Pathway R-HSA-212436
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by Erythropoietin R-HSA-9006335
MAP2K and MAPK activation R-HSA-5674135
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by EGFR in Cancer R-HSA-1643713
DAP12 interactions R-HSA-2172127
GPCR downstream signalling R-HSA-388396
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Activated NTRK3 signals through RAS R-HSA-9034864
SHC1 events in EGFR signaling R-HSA-180336
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by the B Cell Receptor (BCR) R-HSA-983705
RAS GTPase cycle mutants R-HSA-9649913
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
C-type lectin receptors (CLRs) R-HSA-5621481
Transcriptional regulation by RUNX3 R-HSA-8878159
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by FGFR3 in disease R-HSA-5655332
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signalling to RAS R-HSA-167044
Beta-catenin independent WNT signaling R-HSA-3858494
Oncogenic MAPK signaling R-HSA-6802957
Signaling by CSF3 (G-CSF) R-HSA-9674555
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Activation of RAS in B cells R-HSA-1169092
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Downstream signal transduction R-HSA-186763
RAS processing R-HSA-9648002
Signaling by NTRKs R-HSA-166520
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by RAS GAP mutants R-HSA-9753510
VEGFR2 mediated cell proliferation R-HSA-5218921
Downstream signaling of activated FGFR3 R-HSA-5654708
Signalling to ERKs R-HSA-187687
Signaling by FGFR1 R-HSA-5654736
SHC1 events in EGFR signaling R-HSA-180336
Signaling by NTRK3 (TRKC) R-HSA-9034015
Post NMDA receptor activation events R-HSA-438064
Erythropoietin activates RAS R-HSA-9027284
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Hemostasis R-HSA-109582
RAS GTPase cycle mutants R-HSA-9649913
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by the B Cell Receptor (BCR) R-HSA-983705
VEGFA-VEGFR2 Pathway R-HSA-4420097
VEGFR2 mediated cell proliferation R-HSA-5218921
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by FGFR in disease R-HSA-1226099
Signaling by NTRK1 (TRKA) R-HSA-187037
ESR-mediated signaling R-HSA-8939211
SHC-mediated cascade:FGFR4 R-HSA-5654719
Signaling by EGFRvIII in Cancer R-HSA-5637812
Regulation of RAS by GAPs R-HSA-5658442
GRB2 events in EGFR signaling R-HSA-179812
Signaling by ERBB2 in Cancer R-HSA-1227990
Axon guidance R-HSA-422475
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by KIT in disease R-HSA-9669938
Signaling by PTK6 R-HSA-8848021
DAP12 interactions R-HSA-2172127
Insulin receptor signalling cascade R-HSA-74751
GPCR downstream signalling R-HSA-388396
Activated NTRK2 signals through RAS R-HSA-9026519
Constitutive Signaling by EGFRvIII R-HSA-5637810
MET activates RAS signaling R-HSA-8851805
Signaling by PDGFR in disease R-HSA-9671555
Signaling by RAS GAP mutants R-HSA-9753510
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Gene expression (Transcription) R-HSA-74160
Cytokine Signaling in Immune system R-HSA-1280215
MAP2K and MAPK activation R-HSA-5674135
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
SHC-mediated cascade:FGFR1 R-HSA-5654688
Beta-catenin independent WNT signaling R-HSA-3858494
IGF1R signaling cascade R-HSA-2428924
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
GRB2 events in ERBB2 signaling R-HSA-1963640
SHC1 events in ERBB4 signaling R-HSA-1250347
Signalling to ERKs R-HSA-187687
Oncogenic MAPK signaling R-HSA-6802957
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Activated NTRK3 signals through RAS R-HSA-9034864
Signaling by ERBB2 R-HSA-1227986
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by SCF-KIT R-HSA-1433557
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by FGFR2 in disease R-HSA-5655253
Signaling by FGFR4 R-HSA-5654743
Ca2+ pathway R-HSA-4086398
Downstream signaling of activated FGFR2 R-HSA-5654696
SHC-mediated cascade:FGFR2 R-HSA-5654699
Signaling by RAS mutants R-HSA-6802949
Signalling to RAS R-HSA-167044
Signaling by EGFR in Cancer R-HSA-1643713
Tie2 Signaling R-HSA-210993
Transmission across Chemical Synapses R-HSA-112315
Signaling by MET R-HSA-6806834
Signaling by FLT3 fusion proteins R-HSA-9703465
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
RUNX3 regulates p14-ARF R-HSA-8951936
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Downstream signaling of activated FGFR1 R-HSA-5654687
Transcriptional regulation by RUNX3 R-HSA-8878159
SHC-mediated cascade:FGFR3 R-HSA-5654704
Signal Transduction R-HSA-162582
p38MAPK events R-HSA-171007
Immune System R-HSA-168256
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by NTRKs R-HSA-166520
G alpha (q) signalling events R-HSA-416476
Negative regulation of MAPK pathway R-HSA-5675221
Extra-nuclear estrogen signaling R-HSA-9009391
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by FGFR3 R-HSA-5654741
DAP12 signaling R-HSA-2424491
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by RAS GTPase mutants R-HSA-9753512
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Signaling by NTRK2 (TRKB) R-HSA-9006115
FRS-mediated FGFR4 signaling R-HSA-5654712
Generic Transcription Pathway R-HSA-212436
Disease R-HSA-1643685
FCERI mediated MAPK activation R-HSA-2871796
SHC1 events in ERBB2 signaling R-HSA-1250196
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by FGFR R-HSA-190236
C-type lectin receptors (CLRs) R-HSA-5621481
Activation of RAS in B cells R-HSA-1169092
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ERBB4 R-HSA-1236394
NCAM signaling for neurite out-growth R-HSA-375165
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by FGFR2 R-HSA-5654738
Signaling by Erythropoietin R-HSA-9006335
Nervous system development R-HSA-9675108
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by BRAF and RAF1 fusions R-HSA-6802952
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK family signaling cascades R-HSA-5683057
FLT3 signaling in disease R-HSA-9682385
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by PDGF R-HSA-186797
Signaling by FGFR3 in disease R-HSA-5655332
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Developmental Biology R-HSA-1266738
Signaling by VEGF R-HSA-194138
Signaling by FGFR1 in disease R-HSA-5655302
RAF/MAP kinase cascade R-HSA-5673001
Innate Immune System R-HSA-168249
Signaling by RAF1 mutants R-HSA-9656223
Signaling by WNT R-HSA-195721
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by ERBB2 KD Mutants R-HSA-9664565
RAS processing R-HSA-9648002
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
IRS-mediated signalling R-HSA-112399
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by Insulin receptor R-HSA-74752
Downstream signal transduction R-HSA-186763
SOS-mediated signalling R-HSA-112412
Downstream signaling of activated FGFR3 R-HSA-5654708
RNA Polymerase II Transcription R-HSA-73857
Signaling by GPCR R-HSA-372790
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Neuronal System R-HSA-112316
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Adaptive Immune System R-HSA-1280218
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by CSF3 (G-CSF) R-HSA-9674555
FLT3 Signaling R-HSA-9607240
RAF activation R-HSA-5673000
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
SHC-mediated cascade:FGFR3 R-HSA-5654704
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Oncogenic MAPK signaling R-HSA-6802957
Activated NTRK2 signals through RAS R-HSA-9026519
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by VEGF R-HSA-194138
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by WNT R-HSA-195721
Signal Transduction R-HSA-162582
Signaling downstream of RAS mutants R-HSA-9649948
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by FGFR2 in disease R-HSA-5655253
VEGFA-VEGFR2 Pathway R-HSA-4420097
FRS-mediated FGFR4 signaling R-HSA-5654712
Signaling by FGFR in disease R-HSA-1226099
Extra-nuclear estrogen signaling R-HSA-9009391
Innate Immune System R-HSA-168249
SHC1 events in EGFR signaling R-HSA-180336
DAP12 interactions R-HSA-2172127
Erythropoietin activates RAS R-HSA-9027284
MAP2K and MAPK activation R-HSA-5674135
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by MET R-HSA-6806834
MAPK1/MAPK3 signaling R-HSA-5684996
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Signaling by the B Cell Receptor (BCR) R-HSA-983705
RAS processing R-HSA-9648002
RUNX3 regulates p14-ARF R-HSA-8951936
Gene expression (Transcription) R-HSA-74160
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
DAP12 signaling R-HSA-2424491
GPCR downstream signalling R-HSA-388396
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAS GTPase cycle mutants R-HSA-9649913
SOS-mediated signalling R-HSA-112412
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Axon guidance R-HSA-422475
Signalling to RAS R-HSA-167044
RAF/MAP kinase cascade R-HSA-5673001
SHC1 events in ERBB2 signaling R-HSA-1250196
GRB2 events in EGFR signaling R-HSA-179812
Tie2 Signaling R-HSA-210993
Insulin receptor signalling cascade R-HSA-74751
Signalling to ERKs R-HSA-187687
Signaling by FGFR1 in disease R-HSA-5655302
Adaptive Immune System R-HSA-1280218
Signaling by Nuclear Receptors R-HSA-9006931
IRS-related events triggered by IGF1R R-HSA-2428928
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by FGFR4 R-HSA-5654743
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
p38MAPK events R-HSA-171007
SHC1 events in ERBB4 signaling R-HSA-1250347
SHC-mediated cascade:FGFR2 R-HSA-5654699
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Downstream signaling of activated FGFR2 R-HSA-5654696
VEGFR2 mediated cell proliferation R-HSA-5218921
Activation of RAS in B cells R-HSA-1169092
Developmental Biology R-HSA-1266738
Disease R-HSA-1643685
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
RAF activation R-HSA-5673000
FRS-mediated FGFR1 signaling R-HSA-5654693
Generic Transcription Pathway R-HSA-212436
Transmission across Chemical Synapses R-HSA-112315
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by PTK6 R-HSA-8848021
Negative regulation of MAPK pathway R-HSA-5675221
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by RAS GAP mutants R-HSA-9753510
Signaling by SCF-KIT R-HSA-1433557
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by NTRKs R-HSA-166520
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by RAS mutants R-HSA-6802949
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by GPCR R-HSA-372790
Signaling by CSF3 (G-CSF) R-HSA-9674555
SHC-mediated cascade:FGFR4 R-HSA-5654719
Signaling by ERBB2 R-HSA-1227986
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
SHC-related events triggered by IGF1R R-HSA-2428933
RNA Polymerase II Transcription R-HSA-73857
Signaling by NTRK3 (TRKC) R-HSA-9034015
Beta-catenin independent WNT signaling R-HSA-3858494
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Downstream signaling of activated FGFR4 R-HSA-5654716
MET activates RAS signaling R-HSA-8851805
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by Insulin receptor R-HSA-74752
FRS-mediated FGFR2 signaling R-HSA-5654700
MAPK family signaling cascades R-HSA-5683057
Activated NTRK3 signals through RAS R-HSA-9034864
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
NCAM signaling for neurite out-growth R-HSA-375165
C-type lectin receptors (CLRs) R-HSA-5621481
G alpha (q) signalling events R-HSA-416476
IRS-mediated signalling R-HSA-112399
FCERI mediated MAPK activation R-HSA-2871796
Transcriptional regulation by RUNX3 R-HSA-8878159
EGFR Transactivation by Gastrin R-HSA-2179392
FRS-mediated FGFR3 signaling R-HSA-5654706
FLT3 Signaling R-HSA-9607240
Signaling by PDGF R-HSA-186797
Signaling by RAF1 mutants R-HSA-9656223
GRB2 events in ERBB2 signaling R-HSA-1963640
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
ESR-mediated signaling R-HSA-8939211
Neuronal System R-HSA-112316
Signaling by FGFR R-HSA-190236
Hemostasis R-HSA-109582
Signaling by PDGFR in disease R-HSA-9671555
Ca2+ pathway R-HSA-4086398
Signaling by Erythropoietin R-HSA-9006335
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by EGFR R-HSA-177929
Signaling by ERBB4 R-HSA-1236394
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by FGFR3 in disease R-HSA-5655332
Downstream signaling of activated FGFR3 R-HSA-5654708
Downstream signal transduction R-HSA-186763
Immune System R-HSA-168256
Signaling by FGFR2 R-HSA-5654738
Nervous system development R-HSA-9675108
Signaling by RAS GTPase mutants R-HSA-9753512
SHC-mediated cascade:FGFR1 R-HSA-5654688
FLT3 signaling in disease R-HSA-9682385
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Post NMDA receptor activation events R-HSA-438064
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by FGFR3 R-HSA-5654741
Regulation of RAS by GAPs R-HSA-5658442
IGF1R signaling cascade R-HSA-2428924
Signaling by KIT in disease R-HSA-9669938
Signaling by FGFR1 R-HSA-5654736
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by NTRK1 (TRKA) R-HSA-187037
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
SHC1 events in ERBB2 signaling R-HSA-1250196
Gene expression (Transcription) R-HSA-74160
Signaling by FLT3 fusion proteins R-HSA-9703465
Developmental Biology R-HSA-1266738
Signalling to ERKs R-HSA-187687
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Beta-catenin independent WNT signaling R-HSA-3858494
Downstream signaling of activated FGFR3 R-HSA-5654708
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
SHC-mediated cascade:FGFR1 R-HSA-5654688
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
FRS-mediated FGFR4 signaling R-HSA-5654712
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by NTRKs R-HSA-166520
Signaling by EGFR in Cancer R-HSA-1643713
G alpha (q) signalling events R-HSA-416476
Signaling by CSF3 (G-CSF) R-HSA-9674555
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Innate Immune System R-HSA-168249
MAP2K and MAPK activation R-HSA-5674135
Signaling by EGFR R-HSA-177929
DAP12 signaling R-HSA-2424491
Signaling by VEGF R-HSA-194138
Post NMDA receptor activation events R-HSA-438064
RAS GTPase cycle mutants R-HSA-9649913
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by FGFR in disease R-HSA-1226099
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signal Transduction R-HSA-162582
Signaling by Insulin receptor R-HSA-74752
Activation of RAS in B cells R-HSA-1169092
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by FGFR1 in disease R-HSA-5655302
FCERI mediated MAPK activation R-HSA-2871796
Transmission across Chemical Synapses R-HSA-112315
FLT3 Signaling R-HSA-9607240
Signaling by FGFR4 R-HSA-5654743
MAPK1/MAPK3 signaling R-HSA-5684996
FRS-mediated FGFR3 signaling R-HSA-5654706
EGFR Transactivation by Gastrin R-HSA-2179392
Axon guidance R-HSA-422475
ESR-mediated signaling R-HSA-8939211
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Disease R-HSA-1643685
p38MAPK events R-HSA-171007
Extra-nuclear estrogen signaling R-HSA-9009391
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by FGFR4 in disease R-HSA-5655291
SHC-mediated cascade:FGFR4 R-HSA-5654719
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signalling to RAS R-HSA-167044
RUNX3 regulates p14-ARF R-HSA-8951936
Insulin receptor signalling cascade R-HSA-74751
IRS-mediated signalling R-HSA-112399
Adaptive Immune System R-HSA-1280218
Ca2+ pathway R-HSA-4086398
Regulation of RAS by GAPs R-HSA-5658442
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by RAF1 mutants R-HSA-9656223
VEGFR2 mediated cell proliferation R-HSA-5218921
Neuronal System R-HSA-112316
Signaling by ERBB2 R-HSA-1227986
MET activates RAS signaling R-HSA-8851805
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by MET R-HSA-6806834
VEGFA-VEGFR2 Pathway R-HSA-4420097
Signaling by KIT in disease R-HSA-9669938
Signaling by PDGFR in disease R-HSA-9671555
IGF1R signaling cascade R-HSA-2428924
Signaling by ERBB4 R-HSA-1236394
RAS processing R-HSA-9648002
Signaling by ERBB2 ECD mutants R-HSA-9665348
Immune System R-HSA-168256
Activated NTRK3 signals through RAS R-HSA-9034864
Activated NTRK2 signals through RAS R-HSA-9026519
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by FGFR2 in disease R-HSA-5655253
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by FGFR3 in disease R-HSA-5655332
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
SHC1 events in ERBB4 signaling R-HSA-1250347
FLT3 signaling in disease R-HSA-9682385
FRS-mediated FGFR1 signaling R-HSA-5654693
Nervous system development R-HSA-9675108
Signaling by RAS mutants R-HSA-6802949
Signaling by PDGF R-HSA-186797
Signaling by RAS GTPase mutants R-HSA-9753512
RNA Polymerase II Transcription R-HSA-73857
Signaling by SCF-KIT R-HSA-1433557
Downstream signaling of activated FGFR4 R-HSA-5654716
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
SHC-mediated cascade:FGFR3 R-HSA-5654704
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by GPCR R-HSA-372790
Transcriptional regulation by RUNX3 R-HSA-8878159
SOS-mediated signalling R-HSA-112412
Signaling by Erythropoietin R-HSA-9006335
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by FGFR2 R-HSA-5654738
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by the B Cell Receptor (BCR) R-HSA-983705
GRB2 events in EGFR signaling R-HSA-179812
Tie2 Signaling R-HSA-210993
Cytokine Signaling in Immune system R-HSA-1280215
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by WNT R-HSA-195721
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by FGFR1 R-HSA-5654736
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF/MAP kinase cascade R-HSA-5673001
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
IRS-related events triggered by IGF1R R-HSA-2428928
SHC-mediated cascade:FGFR2 R-HSA-5654699
GPCR downstream signalling R-HSA-388396
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by NTRK2 (TRKB) R-HSA-9006115
DAP12 interactions R-HSA-2172127
Signaling by PTK6 R-HSA-8848021
NCAM signaling for neurite out-growth R-HSA-375165
FRS-mediated FGFR2 signaling R-HSA-5654700
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by FGFR3 R-HSA-5654741
Downstream signaling of activated FGFR1 R-HSA-5654687
GRB2 events in ERBB2 signaling R-HSA-1963640
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by ERBB2 KD Mutants R-HSA-9664565
MAPK family signaling cascades R-HSA-5683057
Signaling downstream of RAS mutants R-HSA-9649948
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by EGFRvIII in Cancer R-HSA-5637812
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Hemostasis R-HSA-109582
RAF activation R-HSA-5673000
Erythropoietin activates RAS R-HSA-9027284
Downstream signal transduction R-HSA-186763
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
SHC1 events in EGFR signaling R-HSA-180336
Signaling by RAS GAP mutants R-HSA-9753510
Generic Transcription Pathway R-HSA-212436
Signaling by FGFR R-HSA-190236
Signaling by FGFR4 R-HSA-5654743
FCERI mediated MAPK activation R-HSA-2871796
Signaling by FGFR R-HSA-190236
Activated NTRK2 signals through RAS R-HSA-9026519
Signaling by PDGFR in disease R-HSA-9671555
C-type lectin receptors (CLRs) R-HSA-5621481
IGF1R signaling cascade R-HSA-2428924
Signaling by WNT R-HSA-195721
SHC-mediated cascade:FGFR2 R-HSA-5654699
Signaling by PDGF R-HSA-186797
Developmental Biology R-HSA-1266738
Cell surface interactions at the vascular wall R-HSA-202733
Axon guidance R-HSA-422475
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR R-HSA-177929
Activated NTRK3 signals through RAS R-HSA-9034864
SHC-mediated cascade:FGFR4 R-HSA-5654719
Hemostasis R-HSA-109582
Transmission across Chemical Synapses R-HSA-112315
Ca2+ pathway R-HSA-4086398
VEGFR2 mediated cell proliferation R-HSA-5218921
Nervous system development R-HSA-9675108
Signaling by EGFRvIII in Cancer R-HSA-5637812
MAPK1/MAPK3 signaling R-HSA-5684996
FRS-mediated FGFR3 signaling R-HSA-5654706
Disease R-HSA-1643685
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAS processing R-HSA-9648002
Immune System R-HSA-168256
DAP12 signaling R-HSA-2424491
Signaling by ERBB4 R-HSA-1236394
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signalling to RAS R-HSA-167044
RAF activation R-HSA-5673000
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Oncogenic MAPK signaling R-HSA-6802957
Signaling by GPCR R-HSA-372790
p38MAPK events R-HSA-171007
Signalling to ERKs R-HSA-187687
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by NTRKs R-HSA-166520
FRS-mediated FGFR4 signaling R-HSA-5654712
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by ERBB2 R-HSA-1227986
GRB2 events in ERBB2 signaling R-HSA-1963640
Transcriptional regulation by RUNX3 R-HSA-8878159
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by FGFR2 R-HSA-5654738
MAP2K and MAPK activation R-HSA-5674135
GPCR downstream signalling R-HSA-388396
Neuronal System R-HSA-112316
FLT3 Signaling R-HSA-9607240
Regulation of RAS by GAPs R-HSA-5658442
Gene expression (Transcription) R-HSA-74160
Signaling by ERBB2 in Cancer R-HSA-1227990
FRS-mediated FGFR2 signaling R-HSA-5654700
Tie2 Signaling R-HSA-210993
Post NMDA receptor activation events R-HSA-438064
Signaling by FGFR2 in disease R-HSA-5655253
RAS GTPase cycle mutants R-HSA-9649913
Downstream signal transduction R-HSA-186763
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by Erythropoietin R-HSA-9006335
ESR-mediated signaling R-HSA-8939211
FRS-mediated FGFR1 signaling R-HSA-5654693
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by ERBB2 KD Mutants R-HSA-9664565
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by CSF3 (G-CSF) R-HSA-9674555
MAPK family signaling cascades R-HSA-5683057
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by RAS GAP mutants R-HSA-9753510
SHC1 events in EGFR signaling R-HSA-180336
GRB2 events in EGFR signaling R-HSA-179812
G alpha (q) signalling events R-HSA-416476
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by KIT in disease R-HSA-9669938
SOS-mediated signalling R-HSA-112412
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
VEGFA-VEGFR2 Pathway R-HSA-4420097
EGFR Transactivation by Gastrin R-HSA-2179392
CD209 (DC-SIGN) signaling R-HSA-5621575
SHC-related events triggered by IGF1R R-HSA-2428933
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Insulin receptor signalling cascade R-HSA-74751
NCAM signaling for neurite out-growth R-HSA-375165
Erythropoietin activates RAS R-HSA-9027284
Innate Immune System R-HSA-168249
SHC-mediated cascade:FGFR1 R-HSA-5654688
Downstream signaling of activated FGFR1 R-HSA-5654687
Generic Transcription Pathway R-HSA-212436
Signaling by RAS GTPase mutants R-HSA-9753512
IRS-mediated signalling R-HSA-112399
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by FGFR1 in disease R-HSA-5655302
Signal Transduction R-HSA-162582
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
MET activates RAS signaling R-HSA-8851805
Signaling by FGFR3 R-HSA-5654741
IRS-related events triggered by IGF1R R-HSA-2428928
RUNX3 regulates p14-ARF R-HSA-8951936
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
Signaling by FGFR3 in disease R-HSA-5655332
Adaptive Immune System R-HSA-1280218
Activation of RAS in B cells R-HSA-1169092
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
SHC-mediated cascade:FGFR3 R-HSA-5654704
RAF/MAP kinase cascade R-HSA-5673001
Signaling by VEGF R-HSA-194138
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
FLT3 signaling in disease R-HSA-9682385
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by PTK6 R-HSA-8848021
Signaling by NTRK1 (TRKA) R-HSA-187037
Cytokine Signaling in Immune system R-HSA-1280215
Signaling by Insulin receptor R-HSA-74752
Signaling by MET R-HSA-6806834
DAP12 interactions R-HSA-2172127
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by FGFR in disease R-HSA-1226099
Signaling by FGFR1 R-HSA-5654736
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by RAS mutants R-HSA-6802949
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by SCF-KIT R-HSA-1433557
Signaling by RAF1 mutants R-HSA-9656223
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Beta-catenin independent WNT signaling R-HSA-3858494
Signaling by FGFR4 in disease R-HSA-5655291
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by ERBB2 ECD mutants R-HSA-9665348
Negative regulation of MAPK pathway R-HSA-5675221
IGF1R signaling cascade R-HSA-2428924
FRS-mediated FGFR2 signaling R-HSA-5654700
Cell surface interactions at the vascular wall R-HSA-202733
CD209 (DC-SIGN) signaling R-HSA-5621575
Transmission across Chemical Synapses R-HSA-112315
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Hemostasis R-HSA-109582
Signaling by Insulin receptor R-HSA-74752
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
SHC-mediated cascade:FGFR4 R-HSA-5654719
FRS-mediated FGFR3 signaling R-HSA-5654706
Generic Transcription Pathway R-HSA-212436
Signaling by NTRK2 (TRKB) R-HSA-9006115
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by FGFR1 R-HSA-5654736
Erythropoietin activates RAS R-HSA-9027284
Signaling by CSF3 (G-CSF) R-HSA-9674555
Signaling by FGFR R-HSA-190236
Signaling by PDGF R-HSA-186797
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
SHC1 events in EGFR signaling R-HSA-180336
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
DAP12 interactions R-HSA-2172127
Signaling by ERBB2 ECD mutants R-HSA-9665348
IRS-related events triggered by IGF1R R-HSA-2428928
SHC-mediated cascade:FGFR3 R-HSA-5654704
Oncogenic MAPK signaling R-HSA-6802957
SHC-mediated cascade:FGFR2 R-HSA-5654699
Signaling by FGFR2 R-HSA-5654738
Downstream signaling of activated FGFR3 R-HSA-5654708
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Transcriptional regulation by RUNX3 R-HSA-8878159
Signaling by RAS GAP mutants R-HSA-9753510
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Constitutive Signaling by EGFRvIII R-HSA-5637810
MET activates RAS signaling R-HSA-8851805
Signaling by GPCR R-HSA-372790
Signaling by ERBB2 KD Mutants R-HSA-9664565
Neuronal System R-HSA-112316
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by FGFR2 in disease R-HSA-5655253
Signal Transduction R-HSA-162582
Signaling by MET R-HSA-6806834
RUNX3 regulates p14-ARF R-HSA-8951936
Signaling by KIT in disease R-HSA-9669938
SHC-related events triggered by IGF1R R-HSA-2428933
Beta-catenin independent WNT signaling R-HSA-3858494
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
RAF activation R-HSA-5673000
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
Cytokine Signaling in Immune system R-HSA-1280215
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by PDGFR in disease R-HSA-9671555
Signaling by ERBB2 in Cancer R-HSA-1227990
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NTRK3 (TRKC) R-HSA-9034015
MAP2K and MAPK activation R-HSA-5674135
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Tie2 Signaling R-HSA-210993
Activation of RAS in B cells R-HSA-1169092
Signalling to RAS R-HSA-167044
Signaling by SCF-KIT R-HSA-1433557
Activated NTRK2 signals through RAS R-HSA-9026519
Innate Immune System R-HSA-168249
Signaling by NTRK1 (TRKA) R-HSA-187037
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Signaling by Nuclear Receptors R-HSA-9006931
IRS-mediated signalling R-HSA-112399
FRS-mediated FGFR1 signaling R-HSA-5654693
Immune System R-HSA-168256
Signalling to ERKs R-HSA-187687
RAS processing R-HSA-9648002
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by EGFR in Cancer R-HSA-1643713
Signaling by VEGF R-HSA-194138
Post NMDA receptor activation events R-HSA-438064
Signaling by FGFR3 in disease R-HSA-5655332
Downstream signal transduction R-HSA-186763
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Erythropoietin R-HSA-9006335
GRB2 events in ERBB2 signaling R-HSA-1963640
RNA Polymerase II Transcription R-HSA-73857
Signaling by RAS GTPase mutants R-HSA-9753512
MAPK family signaling cascades R-HSA-5683057
Signaling by FGFR4 R-HSA-5654743
Activated NTRK3 signals through RAS R-HSA-9034864
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Insulin receptor signalling cascade R-HSA-74751
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by EGFR R-HSA-177929
SHC1 events in ERBB4 signaling R-HSA-1250347
Gene expression (Transcription) R-HSA-74160
Signaling by FGFR in disease R-HSA-1226099
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
FCERI mediated MAPK activation R-HSA-2871796
FLT3 Signaling R-HSA-9607240
GRB2 events in EGFR signaling R-HSA-179812
Downstream signaling of activated FGFR2 R-HSA-5654696
Signaling by FLT3 fusion proteins R-HSA-9703465
FLT3 signaling in disease R-HSA-9682385
Signaling by RAS mutants R-HSA-6802949
DAP12 signaling R-HSA-2424491
Adaptive Immune System R-HSA-1280218
ESR-mediated signaling R-HSA-8939211
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
GPCR downstream signalling R-HSA-388396
Disease R-HSA-1643685
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
FRS-mediated FGFR4 signaling R-HSA-5654712
SOS-mediated signalling R-HSA-112412
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
EGFR Transactivation by Gastrin R-HSA-2179392
Axon guidance R-HSA-422475
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by NTRKs R-HSA-166520
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by WNT R-HSA-195721
Regulation of RAS by GAPs R-HSA-5658442
Downstream signaling of activated FGFR4 R-HSA-5654716
Ca2+ pathway R-HSA-4086398
Signaling by FGFR3 R-HSA-5654741
SHC-mediated cascade:FGFR1 R-HSA-5654688
Signaling by EGFRvIII in Cancer R-HSA-5637812
VEGFA-VEGFR2 Pathway R-HSA-4420097
RAS GTPase cycle mutants R-HSA-9649913
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
RAF/MAP kinase cascade R-HSA-5673001
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by FGFR1 in disease R-HSA-5655302
VEGFR2 mediated cell proliferation R-HSA-5218921
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by ERBB2 R-HSA-1227986
G alpha (q) signalling events R-HSA-416476
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by PTK6 R-HSA-8848021
Developmental Biology R-HSA-1266738
Signaling by ERBB4 R-HSA-1236394
Nervous system development R-HSA-9675108
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Tie2 Signaling R-HSA-210993
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by ERBB2 R-HSA-1227986
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by RAF1 mutants R-HSA-9656223
Signalling to RAS R-HSA-167044
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Activation of RAS in B cells R-HSA-1169092
Signaling by KIT in disease R-HSA-9669938
Nervous system development R-HSA-9675108
EGFR Transactivation by Gastrin R-HSA-2179392
Signaling by FGFR4 R-HSA-5654743
IRS-related events triggered by IGF1R R-HSA-2428928
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Transcriptional regulation by RUNX3 R-HSA-8878159
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by PDGFR in disease R-HSA-9671555
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Signaling by FGFR2 R-HSA-5654738
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Neuronal System R-HSA-112316
SHC-mediated cascade:FGFR1 R-HSA-5654688
GRB2 events in EGFR signaling R-HSA-179812
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
MAPK1/MAPK3 signaling R-HSA-5684996
Activated NTRK3 signals through RAS R-HSA-9034864
Post NMDA receptor activation events R-HSA-438064
Developmental Biology R-HSA-1266738
Negative regulation of MAPK pathway R-HSA-5675221
Insulin receptor signalling cascade R-HSA-74751
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
DAP12 signaling R-HSA-2424491
RAF activation R-HSA-5673000
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Activated NTRK2 signals through RAS R-HSA-9026519
SHC-mediated cascade:FGFR3 R-HSA-5654704
SHC-related events triggered by IGF1R R-HSA-2428933
Signaling by ERBB2 ECD mutants R-HSA-9665348
Downstream signaling of activated FGFR2 R-HSA-5654696
FLT3 signaling in disease R-HSA-9682385
Adaptive Immune System R-HSA-1280218
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
SOS-mediated signalling R-HSA-112412
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Innate Immune System R-HSA-168249
RAS processing R-HSA-9648002
Signaling by the B Cell Receptor (BCR) R-HSA-983705
p38MAPK events R-HSA-171007
Erythropoietin activates RAS R-HSA-9027284
Signaling by RAS mutants R-HSA-6802949
Signaling by NTRKs R-HSA-166520
Regulation of RAS by GAPs R-HSA-5658442
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
SHC-mediated cascade:FGFR2 R-HSA-5654699
Signaling by FGFR3 R-HSA-5654741
Signaling by FGFR1 in disease R-HSA-5655302
Signaling by SCF-KIT R-HSA-1433557
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by NTRK1 (TRKA) R-HSA-187037
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
Signaling by RAS GAP mutants R-HSA-9753510
Cytokine Signaling in Immune system R-HSA-1280215
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Signaling by FGFR R-HSA-190236
Ca2+ pathway R-HSA-4086398
ESR-mediated signaling R-HSA-8939211
SHC-mediated cascade:FGFR4 R-HSA-5654719
Signaling by FLT3 fusion proteins R-HSA-9703465
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Axon guidance R-HSA-422475
Signaling by EGFR in Cancer R-HSA-1643713
Signal Transduction R-HSA-162582
VEGFA-VEGFR2 Pathway R-HSA-4420097
Generic Transcription Pathway R-HSA-212436
Extra-nuclear estrogen signaling R-HSA-9009391
FCERI mediated MAPK activation R-HSA-2871796
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by FGFR in disease R-HSA-1226099
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
MAPK family signaling cascades R-HSA-5683057
RAS GTPase cycle mutants R-HSA-9649913
Signaling by CSF3 (G-CSF) R-HSA-9674555
Signaling by NTRK2 (TRKB) R-HSA-9006115
Disease R-HSA-1643685
SHC1 events in EGFR signaling R-HSA-180336
Downstream signal transduction R-HSA-186763
Signalling to ERKs R-HSA-187687
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by MET R-HSA-6806834
VEGFR2 mediated cell proliferation R-HSA-5218921
Downstream signaling of activated FGFR1 R-HSA-5654687
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by PTK6 R-HSA-8848021
Signaling by EGFR R-HSA-177929
IRS-mediated signalling R-HSA-112399
Oncogenic MAPK signaling R-HSA-6802957
Signaling by Erythropoietin R-HSA-9006335
MAP2K and MAPK activation R-HSA-5674135
Signaling by Nuclear Receptors R-HSA-9006931
SHC1 events in ERBB2 signaling R-HSA-1250196
Signaling by RAS GTPase mutants R-HSA-9753512
RNA Polymerase II Transcription R-HSA-73857
Signaling by GPCR R-HSA-372790
Cell surface interactions at the vascular wall R-HSA-202733
Signaling by EGFRvIII in Cancer R-HSA-5637812
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
DAP12 interactions R-HSA-2172127
Gene expression (Transcription) R-HSA-74160
Signaling by Insulin receptor R-HSA-74752
Signaling by ERBB2 KD Mutants R-HSA-9664565
G alpha (q) signalling events R-HSA-416476
IGF1R signaling cascade R-HSA-2428924
Signaling by FGFR2 in disease R-HSA-5655253
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by FGFR1 R-HSA-5654736
Signaling by WNT R-HSA-195721
GRB2 events in ERBB2 signaling R-HSA-1963640
Immune System R-HSA-168256
Beta-catenin independent WNT signaling R-HSA-3858494
Signaling by VEGF R-HSA-194138
GPCR downstream signalling R-HSA-388396
RAF/MAP kinase cascade R-HSA-5673001
RUNX3 regulates p14-ARF R-HSA-8951936
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
FRS-mediated FGFR4 signaling R-HSA-5654712
Transmission across Chemical Synapses R-HSA-112315
Signaling by FGFR3 in disease R-HSA-5655332
FRS-mediated FGFR1 signaling R-HSA-5654693
MET activates RAS signaling R-HSA-8851805
Signaling by PDGF R-HSA-186797
Signaling by ERBB4 R-HSA-1236394
Signaling by FGFR4 in disease R-HSA-5655291
Signaling downstream of RAS mutants R-HSA-9649948
Hemostasis R-HSA-109582
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by ERBB2 in Cancer R-HSA-1227990
FLT3 Signaling R-HSA-9607240
Activation of RAS in B cells R-HSA-1169092
Signaling by PDGFR in disease R-HSA-9671555
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
Disease R-HSA-1643685
Signalling to RAS R-HSA-167044
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by RAS mutants R-HSA-6802949
SOS-mediated signalling R-HSA-112412
Tie2 Signaling R-HSA-210993
Signaling by FGFR R-HSA-190236
GPCR downstream signalling R-HSA-388396
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
Hemostasis R-HSA-109582
Generic Transcription Pathway R-HSA-212436
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Axon guidance R-HSA-422475
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by MET R-HSA-6806834
RUNX3 regulates p14-ARF R-HSA-8951936
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by FGFR4 in disease R-HSA-5655291
Signaling by VEGF R-HSA-194138
SHC1 events in ERBB2 signaling R-HSA-1250196
MAP2K and MAPK activation R-HSA-5674135
RAF/MAP kinase cascade R-HSA-5673001
Signaling by RAS GAP mutants R-HSA-9753510
GRB2 events in ERBB2 signaling R-HSA-1963640
Signaling by Erythropoietin R-HSA-9006335
Signaling by BRAF and RAF1 fusions R-HSA-6802952
SHC-mediated cascade:FGFR2 R-HSA-5654699
Downstream signaling of activated FGFR2 R-HSA-5654696
MET activates RAS signaling R-HSA-8851805
DAP12 signaling R-HSA-2424491
FRS-mediated FGFR1 signaling R-HSA-5654693
Signal Transduction R-HSA-162582
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by ERBB4 R-HSA-1236394
SHC1 events in EGFR signaling R-HSA-180336
ESR-mediated signaling R-HSA-8939211
Transmission across Chemical Synapses R-HSA-112315
Cytokine Signaling in Immune system R-HSA-1280215
p38MAPK events R-HSA-171007
Regulation of RAS by GAPs R-HSA-5658442
FLT3 signaling in disease R-HSA-9682385
Signaling by PDGF R-HSA-186797
Ca2+ pathway R-HSA-4086398
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by CSF3 (G-CSF) R-HSA-9674555
Oncogenic MAPK signaling R-HSA-6802957
Downstream signal transduction R-HSA-186763
EGFR Transactivation by Gastrin R-HSA-2179392
Adaptive Immune System R-HSA-1280218
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
SHC-related events triggered by IGF1R R-HSA-2428933
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
FCERI mediated MAPK activation R-HSA-2871796
SHC-mediated cascade:FGFR1 R-HSA-5654688
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
FLT3 Signaling R-HSA-9607240
Signaling by NTRK3 (TRKC) R-HSA-9034015
SHC1 events in ERBB4 signaling R-HSA-1250347
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
Activation of NMDA receptors and postsynaptic events R-HSA-442755
VEGFA-VEGFR2 Pathway R-HSA-4420097
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Post NMDA receptor activation events R-HSA-438064
NCAM signaling for neurite out-growth R-HSA-375165
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by SCF-KIT R-HSA-1433557
Signaling by Insulin receptor R-HSA-74752
VEGFR2 mediated cell proliferation R-HSA-5218921
FRS-mediated FGFR3 signaling R-HSA-5654706
Signaling by PTK6 R-HSA-8848021
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Activated NTRK3 signals through RAS R-HSA-9034864
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
MAPK family signaling cascades R-HSA-5683057
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Developmental Biology R-HSA-1266738
Signaling by KIT in disease R-HSA-9669938
Insulin receptor signalling cascade R-HSA-74751
Downstream signaling of activated FGFR1 R-HSA-5654687
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
Signaling by RAS GTPase mutants R-HSA-9753512
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
SHC-mediated cascade:FGFR4 R-HSA-5654719
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
RAF activation R-HSA-5673000
Signaling by FGFR2 in disease R-HSA-5655253
Signaling by NTRK2 (TRKB) R-HSA-9006115
Immune System R-HSA-168256
Signaling by FGFR3 R-HSA-5654741
Erythropoietin activates RAS R-HSA-9027284
Cell surface interactions at the vascular wall R-HSA-202733
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by RAF1 mutants R-HSA-9656223
RAS GTPase cycle mutants R-HSA-9649913
Signaling by ERBB2 ECD mutants R-HSA-9665348
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
DAP12 interactions R-HSA-2172127
Signaling by NTRK1 (TRKA) R-HSA-187037
Transcriptional regulation by RUNX3 R-HSA-8878159
Signalling to ERKs R-HSA-187687
Signaling by EGFR in Cancer R-HSA-1643713
CD209 (DC-SIGN) signaling R-HSA-5621575
G alpha (q) signalling events R-HSA-416476
Innate Immune System R-HSA-168249
Signaling by FLT3 fusion proteins R-HSA-9703465
RNA Polymerase II Transcription R-HSA-73857
Signaling by ERBB2 R-HSA-1227986
Neuronal System R-HSA-112316
IRS-mediated signalling R-HSA-112399
SHC-mediated cascade:FGFR3 R-HSA-5654704
Gene expression (Transcription) R-HSA-74160
IGF1R signaling cascade R-HSA-2428924
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Signaling by FGFR in disease R-HSA-1226099
Nervous system development R-HSA-9675108
Signaling by NTRKs R-HSA-166520
GRB2 events in EGFR signaling R-HSA-179812
IRS-related events triggered by IGF1R R-HSA-2428928
RAS processing R-HSA-9648002
Signaling by EGFRvIII in Cancer R-HSA-5637812
Signaling by FGFR1 in disease R-HSA-5655302
Downstream signaling of activated FGFR4 R-HSA-5654716
Signaling by WNT R-HSA-195721
Signaling by FGFR3 in disease R-HSA-5655332
Constitutive Signaling by EGFRvIII R-HSA-5637810
Signaling by FGFR2 R-HSA-5654738
Beta-catenin independent WNT signaling R-HSA-3858494
Activated NTRK2 signals through RAS R-HSA-9026519
Signaling by FGFR1 R-HSA-5654736
FRS-mediated FGFR4 signaling R-HSA-5654712
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by ERBB2 KD Mutants R-HSA-9664565
Signaling by EGFR R-HSA-177929
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
Signaling by FGFR4 R-HSA-5654743
Signaling by GPCR R-HSA-372790
NCAM signaling for neurite out-growth R-HSA-375165
Signaling by FGFR3 in disease R-HSA-5655332
Signalling to RAS R-HSA-167044
Signaling by FGFR4 R-HSA-5654743
Signaling by EGFRvIII in Cancer R-HSA-5637812
C-type lectin receptors (CLRs) R-HSA-5621481
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372
SHC-related events triggered by IGF1R R-HSA-2428933
CD209 (DC-SIGN) signaling R-HSA-5621575
Signaling by PTK6 R-HSA-8848021
Immune System R-HSA-168256
Signaling by FGFR4 in disease R-HSA-5655291
Signalling to ERKs R-HSA-187687
Signaling by ERBB2 R-HSA-1227986
FLT3 signaling in disease R-HSA-9682385
Cytokine Signaling in Immune system R-HSA-1280215
Gene expression (Transcription) R-HSA-74160
SHC1 events in EGFR signaling R-HSA-180336
RAF/MAP kinase cascade R-HSA-5673001
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Neuronal System R-HSA-112316
Signaling by RAF1 mutants R-HSA-9656223
Signaling by Non-Receptor Tyrosine Kinases R-HSA-9006927
Downstream signaling of activated FGFR1 R-HSA-5654687
Signaling by FGFR1 in disease R-HSA-5655302
IGF1R signaling cascade R-HSA-2428924
RAS signaling downstream of NF1 loss-of-function variants R-HSA-6802953
GRB2 events in ERBB2 signaling R-HSA-1963640
RAF activation R-HSA-5673000
Signaling by RAS GAP mutants R-HSA-9753510
Adaptive Immune System R-HSA-1280218
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by ERBB2 in Cancer R-HSA-1227990
Signaling by NTRKs R-HSA-166520
Oncogenic MAPK signaling R-HSA-6802957
Signaling by MET R-HSA-6806834
MET activates RAS signaling R-HSA-8851805
Tie2 Signaling R-HSA-210993
SHC-mediated cascade:FGFR1 R-HSA-5654688
Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849471
SHC-mediated cascade:FGFR2 R-HSA-5654699
FLT3 Signaling R-HSA-9607240
FRS-mediated FGFR1 signaling R-HSA-5654693
Signaling by FGFR2 R-HSA-5654738
Signaling by SCF-KIT R-HSA-1433557
Generic Transcription Pathway R-HSA-212436
Downstream signaling of activated FGFR4 R-HSA-5654716
EGFR Transactivation by Gastrin R-HSA-2179392
IRS-mediated signalling R-HSA-112399
Activation of RAS in B cells R-HSA-1169092
FRS-mediated FGFR4 signaling R-HSA-5654712
Signaling by PDGFRA extracellular domain mutants R-HSA-9673770
Signaling by Insulin receptor R-HSA-74752
RAS GTPase cycle mutants R-HSA-9649913
RUNX3 regulates p14-ARF R-HSA-8951936
Signaling by PDGF R-HSA-186797
Constitutive Signaling by EGFRvIII R-HSA-5637810
Downstream signaling of activated FGFR2 R-HSA-5654696
IRS-related events triggered by IGF1R R-HSA-2428928
VEGFR2 mediated cell proliferation R-HSA-5218921
FRS-mediated FGFR3 signaling R-HSA-5654706
Axon guidance R-HSA-422475
Regulation of RAS by GAPs R-HSA-5658442
Signaling by the B Cell Receptor (BCR) R-HSA-983705
Extra-nuclear estrogen signaling R-HSA-9009391
Signaling by FLT3 fusion proteins R-HSA-9703465
Signaling by Erythropoietin R-HSA-9006335
Signaling by ERBB4 R-HSA-1236394
p38MAPK events R-HSA-171007
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
G alpha (q) signalling events R-HSA-416476
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Downstream signaling of activated FGFR3 R-HSA-5654708
Signaling by FGFR R-HSA-190236
Nervous system development R-HSA-9675108
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382
MAPK1/MAPK3 signaling R-HSA-5684996
Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907
Transcriptional regulation by RUNX3 R-HSA-8878159
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants R-HSA-9673767
Erythropoietin activates RAS R-HSA-9027284
Hemostasis R-HSA-109582
SOS-mediated signalling R-HSA-112412
VEGFA-VEGFR2 Pathway R-HSA-4420097
Innate Immune System R-HSA-168249
Signaling by FLT3 ITD and TKD mutants R-HSA-9703648
Signaling by NTRK2 (TRKB) R-HSA-9006115
Signaling by FGFR in disease R-HSA-1226099
Signaling by EGFR in Cancer R-HSA-1643713
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-442742
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
ESR-mediated signaling R-HSA-8939211
Constitutive Signaling by Overexpressed ERBB2 R-HSA-9634285
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
GRB2 events in EGFR signaling R-HSA-179812
Developmental Biology R-HSA-1266738
Signaling by FGFR1 R-HSA-5654736
Downstream signal transduction R-HSA-186763
Signaling by Nuclear Receptors R-HSA-9006931
Signaling by FGFR2 in disease R-HSA-5655253
SHC-mediated cascade:FGFR3 R-HSA-5654704
SHC1 events in ERBB2 signaling R-HSA-1250196
Transmission across Chemical Synapses R-HSA-112315
Activated NTRK3 signals through RAS R-HSA-9034864
Beta-catenin independent WNT signaling R-HSA-3858494
FRS-mediated FGFR2 signaling R-HSA-5654700
Signaling by KIT in disease R-HSA-9669938
Activated NTRK2 signals through FRS2 and FRS3 R-HSA-9028731
Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112314
Signaling by CSF3 (G-CSF) R-HSA-9674555
Ras activation upon Ca2+ influx through NMDA receptor R-HSA-442982
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-9670439
Signaling by CSF1 (M-CSF) in myeloid cells R-HSA-9680350
SHC-mediated cascade:FGFR4 R-HSA-5654719
Ca2+ pathway R-HSA-4086398
Cell surface interactions at the vascular wall R-HSA-202733
DAP12 signaling R-HSA-2424491
Activation of NMDA receptors and postsynaptic events R-HSA-442755
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by FGFR3 R-HSA-5654741
Signaling by VEGF R-HSA-194138
Signal Transduction R-HSA-162582
GPCR downstream signalling R-HSA-388396
Signaling by PDGFR in disease R-HSA-9671555
MAP2K and MAPK activation R-HSA-5674135
SHC1 events in ERBB4 signaling R-HSA-1250347
Signaling downstream of RAS mutants R-HSA-9649948
Activated NTRK2 signals through RAS R-HSA-9026519
RAS processing R-HSA-9648002
Signaling by ERBB2 ECD mutants R-HSA-9665348
Post NMDA receptor activation events R-HSA-438064
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by ERBB2 TMD/JMD mutants R-HSA-9665686
Signaling by NTRK3 (TRKC) R-HSA-9034015
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192
Signaling by RAS GTPase mutants R-HSA-9753512
Estrogen-stimulated signaling through PRKCZ R-HSA-9634635
DAP12 interactions R-HSA-2172127
Fc epsilon receptor (FCERI) signaling R-HSA-2454202
Signaling by ERBB2 KD Mutants R-HSA-9664565
FCERI mediated MAPK activation R-HSA-2871796
Insulin receptor signalling cascade R-HSA-74751
MAPK family signaling cascades R-HSA-5683057
Signaling by GPCR R-HSA-372790
RNA Polymerase II Transcription R-HSA-73857
Signaling by EGFR R-HSA-177929

Expression Atlas ENSG00000133703
LRG display in Ensembl gene LRG_344
NCBI gene (formerly Entrezgene) 3845
GeneCards 6407
HGNC Symbol HGNC:6407
MIM gene 190070
MIM morbid 615278
UniProtKB Gene Name P01116
WikiGene 3845
Gene: MAP2K2
Ensembl ID : ENSG00000126934
Description: mitogen-activated protein kinase kinase 2
Gene Synonyms: MEK2,PRKMK2
19 APIs:
266 Possible Orthologues:

MAPK family signaling cascades R-HSA-5683057
Signalling to ERKs R-HSA-187687
RAF/MAP kinase cascade R-HSA-5673001
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Oncogenic MAPK signaling R-HSA-6802957
Prolonged ERK activation events R-HSA-169893
Infectious disease R-HSA-5663205
Developmental Biology R-HSA-1266738
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
L1CAM interactions R-HSA-373760
Negative regulation of MAPK pathway R-HSA-5675221
Frs2-mediated activation R-HSA-170968
MAPK1/MAPK3 signaling R-HSA-5684996
RAF activation R-HSA-5673000
Signal transduction by L1 R-HSA-445144
Signaling by NTRKs R-HSA-166520
MAPK1 (ERK2) activation R-HSA-112411
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by MAP2K mutants R-HSA-9652169
Uptake and actions of bacterial toxins R-HSA-5339562
MAP2K and MAPK activation R-HSA-5674135
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by RAS mutants R-HSA-6802949
Signaling by RAF1 mutants R-HSA-9656223
Signaling downstream of RAS mutants R-HSA-9649948
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
RAF-independent MAPK1/3 activation R-HSA-112409
Signal Transduction R-HSA-162582
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAPK family signaling cascades R-HSA-5683057
Axon guidance R-HSA-422475
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by NTRKs R-HSA-166520
Axon guidance R-HSA-422475
Prolonged ERK activation events R-HSA-169893
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Nervous system development R-HSA-9675108
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF activation R-HSA-5673000
MAPK1 (ERK2) activation R-HSA-112411
Infectious disease R-HSA-5663205
Negative regulation of MAPK pathway R-HSA-5675221
Disease R-HSA-1643685
Oncogenic MAPK signaling R-HSA-6802957
Signalling to ERKs R-HSA-187687
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
RAF-independent MAPK1/3 activation R-HSA-112409
L1CAM interactions R-HSA-373760
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by RAS mutants R-HSA-6802949
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Developmental Biology R-HSA-1266738
Signal Transduction R-HSA-162582
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling downstream of RAS mutants R-HSA-9649948
MAPK family signaling cascades R-HSA-5683057
Signal transduction by L1 R-HSA-445144
Signaling by MAP2K mutants R-HSA-9652169
Uptake and actions of bacterial toxins R-HSA-5339562
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Frs2-mediated activation R-HSA-170968
Negative feedback regulation of MAPK pathway R-HSA-5674499
RAF activation R-HSA-5673000
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signal Transduction R-HSA-162582
Axon guidance R-HSA-422475
Infectious disease R-HSA-5663205
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
Frs2-mediated activation R-HSA-170968
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAPK family signaling cascades R-HSA-5683057
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Developmental Biology R-HSA-1266738
RAF/MAP kinase cascade R-HSA-5673001
Disease R-HSA-1643685
Signalling to ERKs R-HSA-187687
Signaling by RAF1 mutants R-HSA-9656223
L1CAM interactions R-HSA-373760
MAP2K and MAPK activation R-HSA-5674135
Uptake and function of anthrax toxins R-HSA-5210891
Prolonged ERK activation events R-HSA-169893
Uptake and actions of bacterial toxins R-HSA-5339562
Oncogenic MAPK signaling R-HSA-6802957
Signaling by NTRK1 (TRKA) R-HSA-187037
RAF-independent MAPK1/3 activation R-HSA-112409
Signal transduction by L1 R-HSA-445144
Signaling by NTRKs R-HSA-166520
Signaling by MAP2K mutants R-HSA-9652169
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Nervous system development R-HSA-9675108
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by RAS mutants R-HSA-6802949
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Uptake and function of anthrax toxins R-HSA-5210891
Disease R-HSA-1643685
Nervous system development R-HSA-9675108
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
Infectious disease R-HSA-5663205
Frs2-mediated activation R-HSA-170968
Signal transduction by L1 R-HSA-445144
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF/MAP kinase cascade R-HSA-5673001
Axon guidance R-HSA-422475
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
Signaling by RAS mutants R-HSA-6802949
Prolonged ERK activation events R-HSA-169893
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of MAPK pathway R-HSA-5675221
Signal Transduction R-HSA-162582
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by NTRKs R-HSA-166520
RAF activation R-HSA-5673000
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling downstream of RAS mutants R-HSA-9649948
Oncogenic MAPK signaling R-HSA-6802957
MAPK1 (ERK2) activation R-HSA-112411
Developmental Biology R-HSA-1266738
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by MAP2K mutants R-HSA-9652169
L1CAM interactions R-HSA-373760
Signal Transduction R-HSA-162582
Negative feedback regulation of MAPK pathway R-HSA-5674499
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by RAF1 mutants R-HSA-9656223
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Uptake and function of anthrax toxins R-HSA-5210891
RAF activation R-HSA-5673000
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Negative regulation of MAPK pathway R-HSA-5675221
Developmental Biology R-HSA-1266738
Signal transduction by L1 R-HSA-445144
Uptake and actions of bacterial toxins R-HSA-5339562
MAP2K and MAPK activation R-HSA-5674135
Nervous system development R-HSA-9675108
MAPK1 (ERK2) activation R-HSA-112411
L1CAM interactions R-HSA-373760
Frs2-mediated activation R-HSA-170968
Signaling by RAS mutants R-HSA-6802949
RAF-independent MAPK1/3 activation R-HSA-112409
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Disease R-HSA-1643685
Prolonged ERK activation events R-HSA-169893
Infectious disease R-HSA-5663205
Oncogenic MAPK signaling R-HSA-6802957
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
RAF/MAP kinase cascade R-HSA-5673001
Axon guidance R-HSA-422475
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by NTRKs R-HSA-166520
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by MAP2K mutants R-HSA-9652169
Signaling by RAS mutants R-HSA-6802949
Uptake and actions of bacterial toxins R-HSA-5339562
Infectious disease R-HSA-5663205
Signaling by RAF1 mutants R-HSA-9656223
Disease R-HSA-1643685
Negative feedback regulation of MAPK pathway R-HSA-5674499
Axon guidance R-HSA-422475
Prolonged ERK activation events R-HSA-169893
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
L1CAM interactions R-HSA-373760
Signalling to ERKs R-HSA-187687
Signal Transduction R-HSA-162582
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by MAP2K mutants R-HSA-9652169
Signaling by NTRKs R-HSA-166520
Oncogenic MAPK signaling R-HSA-6802957
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
MAP2K and MAPK activation R-HSA-5674135
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Negative regulation of MAPK pathway R-HSA-5675221
Signal transduction by L1 R-HSA-445144
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Nervous system development R-HSA-9675108
Uptake and function of anthrax toxins R-HSA-5210891
MAPK1/MAPK3 signaling R-HSA-5684996
MAPK1 (ERK2) activation R-HSA-112411
MAPK family signaling cascades R-HSA-5683057
RAF activation R-HSA-5673000
Frs2-mediated activation R-HSA-170968
Developmental Biology R-HSA-1266738
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by NTRK1 (TRKA) R-HSA-187037
RAF/MAP kinase cascade R-HSA-5673001
Negative regulation of MAPK pathway R-HSA-5675221
Nervous system development R-HSA-9675108
Disease R-HSA-1643685
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling by MAP2K mutants R-HSA-9652169
Axon guidance R-HSA-422475
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling downstream of RAS mutants R-HSA-9649948
L1CAM interactions R-HSA-373760
Oncogenic MAPK signaling R-HSA-6802957
Frs2-mediated activation R-HSA-170968
Signal transduction by L1 R-HSA-445144
Signaling by RAS mutants R-HSA-6802949
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by NTRKs R-HSA-166520
MAPK1 (ERK2) activation R-HSA-112411
Signaling by BRAF and RAF1 fusions R-HSA-6802952
RAF activation R-HSA-5673000
Uptake and function of anthrax toxins R-HSA-5210891
Prolonged ERK activation events R-HSA-169893
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
Infectious disease R-HSA-5663205
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAP2K and MAPK activation R-HSA-5674135
Developmental Biology R-HSA-1266738
Signaling by RAF1 mutants R-HSA-9656223
Signal Transduction R-HSA-162582
Signalling to ERKs R-HSA-187687
Negative feedback regulation of MAPK pathway R-HSA-5674499
MAPK1 (ERK2) activation R-HSA-112411
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
L1CAM interactions R-HSA-373760
Signal Transduction R-HSA-162582
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Developmental Biology R-HSA-1266738
Prolonged ERK activation events R-HSA-169893
RAF-independent MAPK1/3 activation R-HSA-112409
Uptake and function of anthrax toxins R-HSA-5210891
Signaling by RAF1 mutants R-HSA-9656223
RAF/MAP kinase cascade R-HSA-5673001
Uptake and actions of bacterial toxins R-HSA-5339562
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
MAP2K and MAPK activation R-HSA-5674135
Infectious disease R-HSA-5663205
Signaling by MAP2K mutants R-HSA-9652169
Signaling by RAS mutants R-HSA-6802949
Oncogenic MAPK signaling R-HSA-6802957
Signalling to ERKs R-HSA-187687
MAPK family signaling cascades R-HSA-5683057
Axon guidance R-HSA-422475
Signaling downstream of RAS mutants R-HSA-9649948
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by NTRKs R-HSA-166520
Disease R-HSA-1643685
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Frs2-mediated activation R-HSA-170968
Nervous system development R-HSA-9675108
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Signal transduction by L1 R-HSA-445144
RAF activation R-HSA-5673000
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955
Signaling by NTRKs R-HSA-166520
Nervous system development R-HSA-9675108
Signaling downstream of RAS mutants R-HSA-9649948
MAPK family signaling cascades R-HSA-5683057
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signalling to ERKs R-HSA-187687
Signal Transduction R-HSA-162582
Signal transduction by L1 R-HSA-445144
Oncogenic MAPK signaling R-HSA-6802957
Prolonged ERK activation events R-HSA-169893
Uptake and function of anthrax toxins R-HSA-5210891
RAF/MAP kinase cascade R-HSA-5673001
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK1 (ERK2) activation R-HSA-112411
MAPK1/MAPK3 signaling R-HSA-5684996
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Developmental Biology R-HSA-1266738
Signaling by RAS mutants R-HSA-6802949
Disease R-HSA-1643685
Frs2-mediated activation R-HSA-170968
Infectious disease R-HSA-5663205
Signaling by NTRK1 (TRKA) R-HSA-187037
Axon guidance R-HSA-422475
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Signaling by MAP2K mutants R-HSA-9652169
Negative feedback regulation of MAPK pathway R-HSA-5674499
Negative regulation of MAPK pathway R-HSA-5675221
RAF activation R-HSA-5673000
L1CAM interactions R-HSA-373760
RAF-independent MAPK1/3 activation R-HSA-112409
Uptake and actions of bacterial toxins R-HSA-5339562
Signaling by RAF1 mutants R-HSA-9656223
MAP2K and MAPK activation R-HSA-5674135
MAPK1/MAPK3 signaling R-HSA-5684996
RAF/MAP kinase cascade R-HSA-5673001
L1CAM interactions R-HSA-373760
Signaling by moderate kinase activity BRAF mutants R-HSA-6802946
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
Signaling by RAS mutants R-HSA-6802949
Infectious disease R-HSA-5663205
Negative feedback regulation of MAPK pathway R-HSA-5674499
RAF activation R-HSA-5673000
Signaling by high-kinase activity BRAF mutants R-HSA-6802948
Signal transduction by L1 R-HSA-445144
Uptake and actions of bacterial toxins R-HSA-5339562
Nervous system development R-HSA-9675108
MAPK1 (ERK2) activation R-HSA-112411
MAP2K and MAPK activation R-HSA-5674135
Signaling by BRAF and RAF1 fusions R-HSA-6802952
Oncogenic MAPK signaling R-HSA-6802957
Signaling downstream of RAS mutants R-HSA-9649948
Signaling by Receptor Tyrosine Kinases R-HSA-9006934
Diseases of signal transduction by growth factor receptors and second messengers R-HSA-5663202
MAPK family signaling cascades R-HSA-5683057
Negative regulation of MAPK pathway R-HSA-5675221
Signaling by NTRKs R-HSA-166520
Signalling to ERKs R-HSA-187687
Disease R-HSA-1643685
Signaling by NTRK1 (TRKA) R-HSA-187037
Signaling by RAF1 mutants R-HSA-9656223
Prolonged ERK activation events R-HSA-169893
Frs2-mediated activation R-HSA-170968
RAF-independent MAPK1/3 activation R-HSA-112409
Signaling by MAP2K mutants R-HSA-9652169
Uptake and function of anthrax toxins R-HSA-5210891
Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6802955

Expression Atlas ENSG00000126934
LRG display in Ensembl gene LRG_750
NCBI gene (formerly Entrezgene) 5605
GeneCards 6842
HGNC Symbol HGNC:6842
MIM gene 601263
MIM morbid 615280
UniProtKB Gene Name P36507
WikiGene 5605
Gene: CCDC6
Ensembl ID : ENSG00000108091
Description: coiled-coil domain containing 6
Gene Synonyms: D10S170,H4,PTC,PTC1,TPC,TST1
2 APIs:
223 Possible Orthologues:

Expression Atlas ENSG00000108091
NCBI gene (formerly Entrezgene) 8030
GeneCards 18782
HGNC Symbol HGNC:18782
MIM gene 601985
UniProtKB Gene Name Q16204
WikiGene 8030
Gene: ACVRL1
Ensembl ID : ENSG00000139567
Description: activin A receptor like type 1
Gene Synonyms: ACVRLK1,ALK1,HHT,HHT2,ORW2
2 APIs:
358 Possible Orthologues:

Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signal Transduction R-HSA-162582
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signaling by TGFB family members R-HSA-9006936
Signaling by BMP R-HSA-201451
Signal Transduction R-HSA-162582

Expression Atlas ENSG00000139567
LRG display in Ensembl gene LRG_543
NCBI gene (formerly Entrezgene) 94
GeneCards 175
HGNC Symbol HGNC:175
MIM gene 601284
MIM morbid 600376
UniProtKB Gene Name P37023
WikiGene 94
Gene: SI
Ensembl ID : ENSG00000090402
Description: sucrase-isomaltase
Gene Synonyms:
2 APIs:
201 Possible Orthologues:

Digestion and absorption R-HSA-8963743
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Diseases of metabolism R-HSA-5668914
Diseases of carbohydrate metabolism R-HSA-5663084
Disease R-HSA-1643685
Intestinal saccharidase deficiencies R-HSA-5659898
Digestion and absorption R-HSA-8963743
Intestinal saccharidase deficiencies R-HSA-5659898
Disease R-HSA-1643685
Diseases of carbohydrate metabolism R-HSA-5663084
Diseases of metabolism R-HSA-5668914
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Digestion of dietary carbohydrate R-HSA-189085
Disease R-HSA-1643685
Diseases of carbohydrate metabolism R-HSA-5663084
Digestion R-HSA-8935690
Intestinal saccharidase deficiencies R-HSA-5659898
Digestion and absorption R-HSA-8963743
Diseases of metabolism R-HSA-5668914
Digestion and absorption R-HSA-8963743
Intestinal saccharidase deficiencies R-HSA-5659898
Digestion R-HSA-8935690
Diseases of carbohydrate metabolism R-HSA-5663084
Diseases of metabolism R-HSA-5668914
Digestion of dietary carbohydrate R-HSA-189085
Disease R-HSA-1643685
Intestinal saccharidase deficiencies R-HSA-5659898
Disease R-HSA-1643685
Digestion and absorption R-HSA-8963743
Diseases of carbohydrate metabolism R-HSA-5663084
Diseases of metabolism R-HSA-5668914
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Digestion of dietary carbohydrate R-HSA-189085
Digestion R-HSA-8935690
Intestinal saccharidase deficiencies R-HSA-5659898
Diseases of carbohydrate metabolism R-HSA-5663084
Disease R-HSA-1643685
Digestion and absorption R-HSA-8963743
Diseases of metabolism R-HSA-5668914
Disease R-HSA-1643685
Diseases of metabolism R-HSA-5668914
Digestion R-HSA-8935690
Digestion of dietary carbohydrate R-HSA-189085
Digestion and absorption R-HSA-8963743
Diseases of carbohydrate metabolism R-HSA-5663084
Intestinal saccharidase deficiencies R-HSA-5659898

Expression Atlas ENSG00000090402
NCBI gene (formerly Entrezgene) 6476
GeneCards 10856
HGNC Symbol HGNC:10856
MIM gene 609845
MIM morbid 222900
UniProtKB Gene Name P14410
WikiGene 6476
Gene: F7
Ensembl ID : ENSG00000057593
Description: coagulation factor VII
Gene Synonyms:
1 APIs:
203 Possible Orthologues:

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Hemostasis R-HSA-109582
Gamma-carboxylation of protein precursors R-HSA-159740
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Circadian Clock R-HSA-400253
Metabolism of proteins R-HSA-392499
Post-translational protein modification R-HSA-597592
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Gamma-carboxylation of protein precursors R-HSA-159740
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Circadian Clock R-HSA-400253
Hemostasis R-HSA-109582
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Metabolism of proteins R-HSA-392499
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Post-translational protein modification R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Gamma-carboxylation of protein precursors R-HSA-159740
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Circadian Clock R-HSA-400253
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Post-translational protein modification R-HSA-597592
Hemostasis R-HSA-109582
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Metabolism of proteins R-HSA-392499
Gamma-carboxylation of protein precursors R-HSA-159740
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Hemostasis R-HSA-109582
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Post-translational protein modification R-HSA-597592
Circadian Clock R-HSA-400253
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Metabolism of proteins R-HSA-392499
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Post-translational protein modification R-HSA-597592
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Gamma-carboxylation of protein precursors R-HSA-159740
Circadian Clock R-HSA-400253
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Hemostasis R-HSA-109582
Metabolism of proteins R-HSA-392499
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Post-translational protein modification R-HSA-597592
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Hemostasis R-HSA-109582
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Circadian Clock R-HSA-400253
Gamma-carboxylation of protein precursors R-HSA-159740
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Metabolism of proteins R-HSA-392499
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
Metabolism of proteins R-HSA-392499
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Post-translational protein modification R-HSA-597592
Circadian Clock R-HSA-400253
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Hemostasis R-HSA-109582
Gamma-carboxylation of protein precursors R-HSA-159740
Hemostasis R-HSA-109582
Post-translational protein modification R-HSA-597592
Metabolism of proteins R-HSA-392499
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Circadian Clock R-HSA-400253
Gamma-carboxylation of protein precursors R-HSA-159740
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Circadian Clock R-HSA-400253
Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159782
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-HSA-159763
Hemostasis R-HSA-109582
Post-translational protein modification R-HSA-597592
Metabolism of proteins R-HSA-392499
BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108
Gamma-carboxylation of protein precursors R-HSA-159740
Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841
Extrinsic Pathway of Fibrin Clot Formation R-HSA-140834
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-159854
Formation of Fibrin Clot (Clotting Cascade) R-HSA-140877

Expression Atlas ENSG00000057593
LRG display in Ensembl gene LRG_554
NCBI gene (formerly Entrezgene) 2155
GeneCards 3544
HGNC Symbol HGNC:3544
MIM gene 613878
MIM morbid 608446
UniProtKB Gene Name P08709
WikiGene 2155
Gene: AURKA
Ensembl ID : ENSG00000087586
Description: aurora kinase A
Gene Synonyms: AIK,ARK1,AURA,BTAK,PPP1R47,STK15,STK6,STK7
10 APIs:
229 Possible Orthologues:

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
G2/M Transition R-HSA-69275
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Generic Transcription Pathway R-HSA-212436
Mitotic G2-G2/M phases R-HSA-453274
Interaction between PHLDA1 and AURKA R-HSA-8854521
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
Metabolism of proteins R-HSA-392499
SUMOylation R-HSA-2990846
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Regulation of TP53 Activity R-HSA-5633007
Gene expression (Transcription) R-HSA-74160
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
AURKA Activation by TPX2 R-HSA-8854518
Post-translational protein modification R-HSA-597592
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of mitotic cell cycle R-HSA-453276
RNA Polymerase II Transcription R-HSA-73857
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Interaction between PHLDA1 and AURKA R-HSA-8854521
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Transcriptional Regulation by TP53 R-HSA-3700989
Cell Cycle, Mitotic R-HSA-69278
AURKA Activation by TPX2 R-HSA-8854518
Regulation of TP53 Activity R-HSA-5633007
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
Regulation of mitotic cell cycle R-HSA-453276
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Metabolism of proteins R-HSA-392499
SUMOylation R-HSA-2990846
Mitotic G2-G2/M phases R-HSA-453274
Gene expression (Transcription) R-HSA-74160
SUMOylation of DNA replication proteins R-HSA-4615885
Post-translational protein modification R-HSA-597592
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
G2/M Transition R-HSA-69275
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
G2/M Transition R-HSA-69275
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Interaction between PHLDA1 and AURKA R-HSA-8854521
Generic Transcription Pathway R-HSA-212436
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Transcriptional Regulation by TP53 R-HSA-3700989
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Cell Cycle R-HSA-1640170
SUMOylation of DNA replication proteins R-HSA-4615885
Gene expression (Transcription) R-HSA-74160
Metabolism of proteins R-HSA-392499
Regulation of mitotic cell cycle R-HSA-453276
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Mitotic G2-G2/M phases R-HSA-453274
SUMOylation R-HSA-2990846
AURKA Activation by TPX2 R-HSA-8854518
RNA Polymerase II Transcription R-HSA-73857
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Cell Cycle, Mitotic R-HSA-69278
Regulation of TP53 Activity R-HSA-5633007
Regulation of mitotic cell cycle R-HSA-453276
AURKA Activation by TPX2 R-HSA-8854518
Interaction between PHLDA1 and AURKA R-HSA-8854521
Cell Cycle R-HSA-1640170
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
SUMOylation of DNA replication proteins R-HSA-4615885
Post-translational protein modification R-HSA-597592
Regulation of TP53 Activity R-HSA-5633007
Mitotic G2-G2/M phases R-HSA-453274
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
Cell Cycle, Mitotic R-HSA-69278
Metabolism of proteins R-HSA-392499
G2/M Transition R-HSA-69275
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
SUMOylation R-HSA-2990846
Gene expression (Transcription) R-HSA-74160
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
RNA Polymerase II Transcription R-HSA-73857
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
Regulation of TP53 Activity R-HSA-5633007
AURKA Activation by TPX2 R-HSA-8854518
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Post-translational protein modification R-HSA-597592
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of mitotic cell cycle R-HSA-453276
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Cell Cycle R-HSA-1640170
Metabolism of proteins R-HSA-392499
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Generic Transcription Pathway R-HSA-212436
RNA Polymerase II Transcription R-HSA-73857
Mitotic G2-G2/M phases R-HSA-453274
G2/M Transition R-HSA-69275
Gene expression (Transcription) R-HSA-74160
Cell Cycle, Mitotic R-HSA-69278
SUMOylation R-HSA-2990846
Interaction between PHLDA1 and AURKA R-HSA-8854521
Transcriptional Regulation by TP53 R-HSA-3700989
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Transcriptional Regulation by TP53 R-HSA-3700989
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Metabolism of proteins R-HSA-392499
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Interaction between PHLDA1 and AURKA R-HSA-8854521
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Post-translational protein modification R-HSA-597592
SUMOylation of DNA replication proteins R-HSA-4615885
AURKA Activation by TPX2 R-HSA-8854518
Regulation of mitotic cell cycle R-HSA-453276
G2/M Transition R-HSA-69275
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
SUMOylation R-HSA-2990846
Cell Cycle, Mitotic R-HSA-69278
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Gene expression (Transcription) R-HSA-74160
Regulation of TP53 Activity R-HSA-5633007
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
Mitotic G2-G2/M phases R-HSA-453274
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
AURKA Activation by TPX2 R-HSA-8854518
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Gene expression (Transcription) R-HSA-74160
Post-translational protein modification R-HSA-597592
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Generic Transcription Pathway R-HSA-212436
Cell Cycle, Mitotic R-HSA-69278
Mitotic G2-G2/M phases R-HSA-453274
SUMOylation R-HSA-2990846
Transcriptional Regulation by TP53 R-HSA-3700989
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of TP53 Activity R-HSA-5633007
Metabolism of proteins R-HSA-392499
Cell Cycle R-HSA-1640170
RNA Polymerase II Transcription R-HSA-73857
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Regulation of mitotic cell cycle R-HSA-453276
Interaction between PHLDA1 and AURKA R-HSA-8854521
G2/M Transition R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
Metabolism of proteins R-HSA-392499
Interaction between PHLDA1 and AURKA R-HSA-8854521
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Post-translational protein modification R-HSA-597592
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Generic Transcription Pathway R-HSA-212436
Cell Cycle R-HSA-1640170
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of TP53 Activity R-HSA-5633007
G2/M Transition R-HSA-69275
Regulation of mitotic cell cycle R-HSA-453276
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
RNA Polymerase II Transcription R-HSA-73857
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
Cell Cycle, Mitotic R-HSA-69278
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
AURKA Activation by TPX2 R-HSA-8854518
Transcriptional Regulation by TP53 R-HSA-3700989
Gene expression (Transcription) R-HSA-74160
SUMOylation R-HSA-2990846
Mitotic G2-G2/M phases R-HSA-453274
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
Mitotic G2-G2/M phases R-HSA-453274
Cell Cycle, Mitotic R-HSA-69278
Cell Cycle R-HSA-1640170
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
AURKA Activation by TPX2 R-HSA-8854518
RNA Polymerase II Transcription R-HSA-73857
Regulation of mitotic cell cycle R-HSA-453276
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
G2/M Transition R-HSA-69275
Transcriptional Regulation by TP53 R-HSA-3700989
Generic Transcription Pathway R-HSA-212436
Gene expression (Transcription) R-HSA-74160
SUMOylation R-HSA-2990846
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Metabolism of proteins R-HSA-392499
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of TP53 Activity R-HSA-5633007
Interaction between PHLDA1 and AURKA R-HSA-8854521
Post-translational protein modification R-HSA-597592
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cell Cycle, Mitotic R-HSA-69278
Generic Transcription Pathway R-HSA-212436
Transcriptional Regulation by TP53 R-HSA-3700989
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
Cell Cycle R-HSA-1640170
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
G2/M Transition R-HSA-69275
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
Regulation of TP53 Activity R-HSA-5633007
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
RNA Polymerase II Transcription R-HSA-73857
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
AURKA Activation by TPX2 R-HSA-8854518
Interaction between PHLDA1 and AURKA R-HSA-8854521
SUMOylation R-HSA-2990846
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
Metabolism of proteins R-HSA-392499
Regulation of mitotic cell cycle R-HSA-453276
Post-translational protein modification R-HSA-597592
Gene expression (Transcription) R-HSA-74160
Mitotic G2-G2/M phases R-HSA-453274
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
Regulation of TP53 Activity through Phosphorylation R-HSA-6804756
Cell Cycle R-HSA-1640170
Post-translational protein modification R-HSA-597592
Gene expression (Transcription) R-HSA-74160
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804114
Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942
SUMOylation of DNA replication proteins R-HSA-4615885
Regulation of TP53 Activity R-HSA-5633007
Interaction between PHLDA1 and AURKA R-HSA-8854521
APC/C-mediated degradation of cell cycle proteins R-HSA-174143
Mitotic G2-G2/M phases R-HSA-453274
RNA Polymerase II Transcription R-HSA-73857
Regulation of mitotic cell cycle R-HSA-453276
Cell Cycle, Mitotic R-HSA-69278
Transcriptional Regulation by TP53 R-HSA-3700989
Metabolism of proteins R-HSA-392499
TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6791312
G2/M Transition R-HSA-69275
Generic Transcription Pathway R-HSA-212436
SUMOylation R-HSA-2990846
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854050
SUMO E3 ligases SUMOylate target proteins R-HSA-3108232
AURKA Activation by TPX2 R-HSA-8854518

Expression Atlas ENSG00000087586
NCBI gene (formerly Entrezgene) 6790
GeneCards 11393
HGNC Symbol HGNC:11393
MIM gene 603072
MIM morbid 114500
UniProtKB Gene Name Q5QPD4
WikiGene 6790
Gene: PAK4
Ensembl ID : ENSG00000130669
Description: p21 (RAC1) activated kinase 4
Gene Synonyms:
1 APIs:
160 Possible Orthologues:

RHOV GTPase cycle R-HSA-9013424
RHOH GTPase cycle R-HSA-9013407
Developmental Biology R-HSA-1266738
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
Activation of RAC1 R-HSA-428540
RAC2 GTPase cycle R-HSA-9013404
RHO GTPase cycle R-HSA-9012999
Nervous system development R-HSA-9675108
RHOJ GTPase cycle R-HSA-9013409
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
RHOQ GTPase cycle R-HSA-9013406
Signal Transduction R-HSA-162582
CDC42 GTPase cycle R-HSA-9013148
RAC3 GTPase cycle R-HSA-9013423
RHOG GTPase cycle R-HSA-9013408
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC2 GTPase cycle R-HSA-9013404
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
Signal Transduction R-HSA-162582
RHOV GTPase cycle R-HSA-9013424
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
Developmental Biology R-HSA-1266738
Activation of RAC1 R-HSA-428540
CDC42 GTPase cycle R-HSA-9013148
RHOU GTPase cycle R-HSA-9013420
RAC1 GTPase cycle R-HSA-9013149
RHOJ GTPase cycle R-HSA-9013409
Signaling by ROBO receptors R-HSA-376176
RHOH GTPase cycle R-HSA-9013407
RHOQ GTPase cycle R-HSA-9013406
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
RHOJ GTPase cycle R-HSA-9013409
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC3 GTPase cycle R-HSA-9013423
Signaling by Rho GTPases R-HSA-194315
RHOG GTPase cycle R-HSA-9013408
RHOV GTPase cycle R-HSA-9013424
CDC42 GTPase cycle R-HSA-9013148
Signal Transduction R-HSA-162582
RAC2 GTPase cycle R-HSA-9013404
RHO GTPase cycle R-HSA-9012999
Nervous system development R-HSA-9675108
RHOQ GTPase cycle R-HSA-9013406
RHOU GTPase cycle R-HSA-9013420
Activation of RAC1 R-HSA-428540
Signaling by ROBO receptors R-HSA-376176
RHOH GTPase cycle R-HSA-9013407
Axon guidance R-HSA-422475
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
RHOJ GTPase cycle R-HSA-9013409
RHO GTPase cycle R-HSA-9012999
Activation of RAC1 R-HSA-428540
RAC1 GTPase cycle R-HSA-9013149
RAC3 GTPase cycle R-HSA-9013423
RHOG GTPase cycle R-HSA-9013408
RHOH GTPase cycle R-HSA-9013407
Signaling by Rho GTPases R-HSA-194315
Nervous system development R-HSA-9675108
RAC2 GTPase cycle R-HSA-9013404
Signal Transduction R-HSA-162582
Signaling by ROBO receptors R-HSA-376176
Developmental Biology R-HSA-1266738
RHOV GTPase cycle R-HSA-9013424
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOU GTPase cycle R-HSA-9013420
RHOQ GTPase cycle R-HSA-9013406
Signal Transduction R-HSA-162582
CDC42 GTPase cycle R-HSA-9013148
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RAC2 GTPase cycle R-HSA-9013404
RHOH GTPase cycle R-HSA-9013407
Activation of RAC1 R-HSA-428540
Signaling by Rho GTPases R-HSA-194315
RAC1 GTPase cycle R-HSA-9013149
RHOG GTPase cycle R-HSA-9013408
RHOV GTPase cycle R-HSA-9013424
RHOU GTPase cycle R-HSA-9013420
RHOJ GTPase cycle R-HSA-9013409
RAC3 GTPase cycle R-HSA-9013423
RHO GTPase cycle R-HSA-9012999
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
RHOQ GTPase cycle R-HSA-9013406
RAC3 GTPase cycle R-HSA-9013423
Signaling by ROBO receptors R-HSA-376176
Nervous system development R-HSA-9675108
Axon guidance R-HSA-422475
Signaling by Rho GTPases R-HSA-194315
CDC42 GTPase cycle R-HSA-9013148
RAC1 GTPase cycle R-HSA-9013149
RHOJ GTPase cycle R-HSA-9013409
RHOU GTPase cycle R-HSA-9013420
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Activation of RAC1 R-HSA-428540
Signal Transduction R-HSA-162582
Developmental Biology R-HSA-1266738
RHOV GTPase cycle R-HSA-9013424
RHOQ GTPase cycle R-HSA-9013406
RAC2 GTPase cycle R-HSA-9013404
RHOH GTPase cycle R-HSA-9013407
RHO GTPase cycle R-HSA-9012999
RHOG GTPase cycle R-HSA-9013408
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RHOQ GTPase cycle R-HSA-9013406
Activation of RAC1 R-HSA-428540
RHOG GTPase cycle R-HSA-9013408
RHOH GTPase cycle R-HSA-9013407
RHOU GTPase cycle R-HSA-9013420
Signal Transduction R-HSA-162582
RAC2 GTPase cycle R-HSA-9013404
RAC1 GTPase cycle R-HSA-9013149
Axon guidance R-HSA-422475
Developmental Biology R-HSA-1266738
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases R-HSA-194315
Nervous system development R-HSA-9675108
RHOJ GTPase cycle R-HSA-9013409
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHOV GTPase cycle R-HSA-9013424
RAC3 GTPase cycle R-HSA-9013423
Axon guidance R-HSA-422475
RHOQ GTPase cycle R-HSA-9013406
RHOH GTPase cycle R-HSA-9013407
CDC42 GTPase cycle R-HSA-9013148
Nervous system development R-HSA-9675108
Activation of RAC1 R-HSA-428540
RAC3 GTPase cycle R-HSA-9013423
Signal Transduction R-HSA-162582
Signaling by ROBO receptors R-HSA-376176
RHOV GTPase cycle R-HSA-9013424
RHOG GTPase cycle R-HSA-9013408
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
RHO GTPase cycle R-HSA-9012999
RHOJ GTPase cycle R-HSA-9013409
Developmental Biology R-HSA-1266738
Signaling by Rho GTPases R-HSA-194315
RAC1 GTPase cycle R-HSA-9013149
RHOU GTPase cycle R-HSA-9013420
RAC2 GTPase cycle R-HSA-9013404
Axon guidance R-HSA-422475
RHOU GTPase cycle R-HSA-9013420
RAC1 GTPase cycle R-HSA-9013149
Signaling by ROBO receptors R-HSA-376176
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 R-HSA-9716542
Signaling by Rho GTPases R-HSA-194315
Developmental Biology R-HSA-1266738
RHOJ GTPase cycle R-HSA-9013409
Activation of RAC1 R-HSA-428540
Signal Transduction R-HSA-162582
RHOH GTPase cycle R-HSA-9013407
RHOQ GTPase cycle R-HSA-9013406
RAC2 GTPase cycle R-HSA-9013404
RHOG GTPase cycle R-HSA-9013408
RAC3 GTPase cycle R-HSA-9013423
RHO GTPase cycle R-HSA-9012999
CDC42 GTPase cycle R-HSA-9013148
RHOV GTPase cycle R-HSA-9013424
Nervous system development R-HSA-9675108

Expression Atlas ENSG00000130669
NCBI gene (formerly Entrezgene) 10298
GeneCards 16059
HGNC Symbol HGNC:16059
MIM gene 605451
UniProtKB Gene Name O96013
WikiGene 10298