TRIAZOPHOS

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Molecule Category Free-form
UNII 6099J8L0EE
Source Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Sci Data. 2015 Jul 7;2:150032. Read more ...

Structure

InChI Key AMFGTOFWMRQMEM-UHFFFAOYSA-N
Smiles CCOP(=S)(OCC)Oc1ncn(n1)c2ccccc2
InChI
InChI=1S/C12H16N3O3PS/c1-3-16-19(20,17-4-2)18-12-13-10-15(14-12)11-8-6-5-7-9-11/h5-10H,3-4H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C12H16N3O3PS
Molecular Weight 313.31
AlogP 3.07
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 7.0
Polar Surface Area 100.3
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 20.0
Assay Description Organism Bioactivity Reference
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.38 to 2.11 nematode population/cm3 soil) Rotylenchulus reniformis 2.0 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.38 to 2.11 nematode population/cm3 soil) Rotylenchulus reniformis 2.5 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 2.24 to 3.51 J2 population/cm3 soil) Meloidogyne incognita 2.01 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 2.24 to 3.51 J2 population/cm3 soil) Meloidogyne incognita 3.24 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.38 to 2.11 nematode population/cm3 soil) Rotylenchulus reniformis 2.59 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.38 to 2.11 nematode population/cm3 soil) Rotylenchulus reniformis 3.67 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 2.24 to 3.51 J2 population/cm3 soil) Meloidogyne incognita 1.64 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 2.24 to 3.51 J2 population/cm3 soil) Meloidogyne incognita 2.11 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested tomato plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredient/hectare Rotylenchulus reniformis 31.0 %
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested in tomato plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredient/hectare Rotylenchulus reniformis 30.0 %
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredient/hectare Rotylenchulus reniformis 30.0 %
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredient/hectare Rotylenchulus reniformis 38.0 %
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredient/hectare Meloidogyne incognita 38.0 %
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as reduction in nematode population measured 110 days post dose following field application at 1 to 2 kg of active ingredient/hectare Meloidogyne incognita 44.0 %
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested tomato plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredient/hectare Meloidogyne incognita 55.0 %
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as reduction in nematode population measured 55 days post dose following field application at 1 to 2 kg of active ingredient/hectare Meloidogyne incognita 63.0 %
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.8 to 3.15 nematode population/cm3 soil) Rotylenchulus reniformis 1.25 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.8 to 3.15 nematode population/cm3 soil) Rotylenchulus reniformis 2.25 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 2.45 to 4.3 J2 population/cm3 soil) Meloidogyne incognita 1.5 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 110 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 2.45 to 4.3 J2 population/cm3 soil) Meloidogyne incognita 2.25 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 1.8 to 3.15 nematode population/cm3 soil) Rotylenchulus reniformis 1.4 /cm3
Nematicidal activity against Rotylenchulus reniformis (reniform nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 1.8 to 3.15 nematode population/cm3 soil) Rotylenchulus reniformis 2.6 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 2 kg of active ingredient/hectare (Rvb = 2.45 to 4.3 J2 population/cm3 soil) Meloidogyne incognita 1.1 /cm3
Nematicidal activity against root-knot nematode Meloidogyne incognita J2 (root-knot nematode) infested chickpea plants plots assessed as nematode population per cm3 soil measured 55 days post dose following field application at 1 kg of active ingredient/hectare (Rvb = 2.45 to 4.3 J2 population/cm3 soil) Meloidogyne incognita 1.7 /cm3
Drug level in Solanum lycopersicum (tomato) green seeds measured 120 days post dose following field application at 2 kg of active ingredient/hectare Solanum lycopersicum None
Drug level in Solanum lycopersicum (tomato) green seeds measured 100 days post dose following field application at 2 kg of active ingredient/hectare Solanum lycopersicum None
Drug level in Solanum lycopersicum (tomato) green seeds measured 90 days post dose following field application at 2 kg of active ingredient/hectare Solanum lycopersicum 0.004 ug/g
Drug level in Solanum lycopersicum (tomato) green seeds measured 120 days post dose following field application at 1 kg of active ingredient/hectare Solanum lycopersicum None
Drug level in Solanum lycopersicum (tomato) green seeds measured 100 days post dose following field application at 1 kg of active ingredient/hectare Solanum lycopersicum None
Drug level in Solanum lycopersicum (tomato) green seeds measured 90 days post dose following field application at 1 kg of active ingredient/hectare Solanum lycopersicum 0.002 ug/g
Drug level in Cicer arietinum (chickpea) green seeds measured 120 days post dose following field application at 2 kg of active ingredient/hectare Cicer arietinum None
Drug level in Cicer arietinum (chickpea) green seeds measured 100 days post dose following field application at 2 kg of active ingredient/hectare Cicer arietinum 0.007 ug/g
Drug level in Cicer arietinum (chickpea) green seeds measured 90 days post dose following field application at 2 kg of active ingredient/hectare Cicer arietinum 0.018 ug/g
Drug level in Cicer arietinum (chickpea) green seeds measured 120 days post dose following field application at 1 kg of active ingredient/hectare Cicer arietinum None
Drug level in Cicer arietinum (chickpea) green seeds measured 100 days post dose following field application at 1 kg of active ingredient/hectare Cicer arietinum 0.004 ug/g
Drug level in Cicer arietinum (chickpea) green seeds measured 90 days post dose following field application at 1 kg of active ingredient/hectare Cicer arietinum 0.011 ug/g
Solubility in water None 30.0 ug.mL-1
Drug level in Triticum aestivum (wheat) plant roots measured post dose following field application Triticum aestivum 44.5 ug/g
Drug level in Solanum lycopersicum (tomato) roots measured post dose following field application at 1 and 2 kg of active ingredient/hectare Solanum lycopersicum 7.22 ug/g
Cmax in Cicer arietinum (chickpea) shoots measured 30 days post dose following field application at 1 and 2 kg of active ingredient/hectare Cicer arietinum 0.25 ug/g
Cmax in Solanum lycopersicum (tomato) shoots measured 45 days post dose following field application at 1 and 2 kg of active ingredient/hectare Solanum lycopersicum 0.63 ug/g
Drug translocation in Solanum lycopersicum (tomato) roots assessed as mean drug level measured post dose following field application at 1 and 2 kg of active ingredient/hectare Solanum lycopersicum 0.14 ug/g
Drug absorption in Solanum lycopersicum (tomato) roots assessed as mean drug level measured post dose following field application at 1 and 2 kg of active ingredient/hectare Solanum lycopersicum 2.77 ug/g
Drug absorption in Cicer arietinum (chickpea) roots measured 45 days post dose following field application at 1 and 2 kg of active ingredient/hectare Cicer arietinum 1.72 ug/g
Drug absorption in Solanum lycopersicum (tomato) roots measured 30 days post dose following field application at 1 and 2 kg of active ingredient/hectare Solanum lycopersicum 7.22 ug/g
Toxicity in Rattus norvegicus (rat) Rattus norvegicus 68.0 mg.kg-1
Residual toxicity against compound treated rice leaves-fed adult Anagrus nilaparvatae assessed as mortality measured on day 7 post insecticide treatment to plant Anagrus 54.6 %
Acute oral toxicity against female adult Anagrus nilaparvatae in petridish under laboratory conditions assessed as mortality compound treated as emulsible concentrate with acetone and Triton X-100 measured after 8 hr Anagrus 100.0 %
Acute contact toxicity against adult Anagrus nilaparvatae assessed as dead parasitoid wasps compound treated for 1 hr measured after 8 hr wash-out period Anagrus 1.25 mgAi/L
Risk quotient, recommended field rate (g/ha) to LC50 for Trichogramma nubilale (mg/L) Trichogramma nubilale 331.5
Contact toxicity against Trichogramma nubilale assessed as mortality after 24 hr by modified slight dry film method Trichogramma nubilale 21.65 mgAi/L Contact toxicity against Trichogramma nubilale assessed as mortality after 24 hr by modified slight dry film method Trichogramma nubilale 1.81 mgAi/L

Cross References

Resources Reference
ChEMBL CHEMBL1553726
FDA SRS 6099J8L0EE
PDB WYW
PubChem 32184
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