PROPARGITE

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Search structure


Source	Gaulton A, Kale N, van Westen GJ, Bellis LJ, Bento AP, Davies M, Hersey A, Papadatos G, Forster M, Wege P, Overington JP. A large-scale crop protection bioassay data set. Sci Data. 2015 Jul 7;2:150032. Read more ...


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	ZYHMJXZULPZUED-UHFFFAOYSA-N
Smiles	CC(C)(C)c1ccc(OC2CCCCC2OS(=O)OCC#C)cc1
InChI	InChI=1S/C19H26O4S/c1-5-14-21-24(20)23-18-9-7-6-8-17(18)22-16-12-10-15(11-13-16)19(2,3)4/h1,10-13,17-18H,6-9,14H2,2-4H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C19H26O4S
Molecular Weight	350.47
AlogP	5.53
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	7.0
Polar Surface Area	63.97
Molecular species	None
Aromatic Rings	1.0
Heavy Atoms	24.0

Assay Description	Organism	Bioactivity	Reference
Resistant ratio, LC50 for Tetranychus urticae FPY 14 (two-spotted spider mite) to LC50 for Tetranychus urticae GSS	Tetranychus urticae	6.43
Insecticidal activity against Tetranychus urticae FPY 14 (two-spotted spider mite) assessed as mortality at 26 +/- 2 degC with 60 +/- 5% RH for first 24 hr	Tetranychus urticae	482.52 mgAi/L
Insecticidal activity against Tetranychus urticae GSS (two-spotted spider mite) assessed as mortality at 26 +/- 2 degC with 60 +/- 5% RH for first 24 hr	Tetranychus urticae	75.0 mgAi/L

Cross References

Resources	Reference
ChEMBL	CHEMBL1416084
PubChem	4936
SureChEMBL	SCHEMBL15358

CONTENTS

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).