Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication in presence of 25 ug/mL quassinoid nigakilactone B measured 48 hr after compound exposure by leaf-disk method
|
Tobacco mosaic virus
|
129000.0
nM
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication measured 48 hr after compound exposure by leaf-disk method
|
Tobacco mosaic virus
|
135000.0
nM
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral infection at 50 ug/mL using compound pre-treated virus suspension measured 5 to 6 days after compound exposure
|
Tobacco mosaic virus
|
60.0
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral infection at 50 ug/mL using compound pre-treated virus suspension in presence of 25 ug/mL quassinoid nigakilactone B measured 5 to 6 days after compound exposure
|
Tobacco mosaic virus
|
55.6
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication at 50 ug/mL in presence of 25 ug/mL quassinoid nigakilactone B measured 48 hr after compound exposure by leaf-disk method
|
Tobacco mosaic virus
|
52.6
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana tabacum cv. K326 leaves assessed as inhibition of viral replication at 50 ug/mL measured 48 hr after compound exposure by leaf-disk method
|
Tobacco mosaic virus
|
51.0
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral replication at 50 ug/mL in presence of 25 ug/mL quassinoid nigakilactone B measured 48 hr after compound exposure by half leaf method
|
Tobacco mosaic virus
|
53.8
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
Antiviral activity against Tobacco mosaic virus U1 (TMV) infected Nicotiana glutinosa leaves assessed as inhibition of viral replication at 50 ug/mL measured 48 hr after compound exposure by half leaf method
|
Tobacco mosaic virus
|
54.5
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 15
First Page : 6590
Last Page : 6595
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect by decreasing local lesion number at 500 mg/l co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
96.0
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2730
Last Page : 2735
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as curative effect by decreasing local lesion number at 500 mg/l treated after viral inoculation measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
58.9
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2730
Last Page : 2735
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as protective effect by decreasing local lesion number at 500 mg/l treated 12 hr before viral inoculation measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
57.7
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2730
Last Page : 2735
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 125 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method
|
Tobacco mosaic virus
|
27.0
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 250 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method
|
Tobacco mosaic virus
|
42.1
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 500 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method
|
Tobacco mosaic virus
|
59.3
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 500 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
23.0
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 500 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
50.5
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 500 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
51.3
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution for 20 min and measured 72 hr post compound treatment by half-leaf method
|
Tobacco mosaic virus
|
440.0
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on fresh tobacco leaves followed by dipping into compound solution at 25 ug/mL for 20 min and measured 72 hr post compound treatment by half-leaf method
|
Tobacco mosaic virus
|
28.2
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 5
First Page : 2703
Last Page : 2709
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 100 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
39.0
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 23
First Page : 12337
Last Page : 12342
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 500 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
47.9
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 23
First Page : 12337
Last Page : 12342
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 100 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
48.0
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 23
First Page : 12337
Last Page : 12342
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 500 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
68.4
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 23
First Page : 12337
Last Page : 12342
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 100 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
47.5
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 23
First Page : 12337
Last Page : 12342
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 500 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
48.7
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 23
First Page : 12337
Last Page : 12342
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
55.6
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 62.5 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
69.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 125 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
78.4
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 250 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
100.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
245.9
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 125 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
40.9
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 250 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
51.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 500 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
55.4
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 500 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
100.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 500 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
60.2
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 3
First Page : 998
Last Page : 1001
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
50.9
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 30.7 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
42.1
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 62.5 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
60.1
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 125 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
70.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 250 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
80.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on whole Nicotiana tabacum leaves followed by smearing with 500 ug/mL compound solution on left side of leaves assessed as viral infection curative effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
55.8
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) pre-treated with 500 ug/mL compound for 30 min followed by inoculation on left side of Nicotiana tabacum leaves assessed as virus inactivation effect measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
99.5
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Antiviral activity against Tobacco mosaic virus (TMV) inoculated on 500 ug/mL compound smeared Nicotiana tabacum leaves assessed as protective effect against viral infection measured 3 to 4 days post viral infection
|
Tobacco mosaic virus
|
59.9
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 13
First Page : 5242
Last Page : 5246
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa at 200 ug/ml after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
42.1
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana tabacum cv. K326 at 30 ug/ml by DAS-ELISA method
|
Tobacco mosaic virus
|
56.5
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa assessed as infection inhibition rate at 30 ug/ml after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
42.6
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa assessed as infection inhibition rate at 25 ug/ml after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
38.3
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa assessed as infection inhibition rate at 20 ug/ml after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
32.1
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa assessed as infection inhibition rate at 15 ug/ml after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
30.3
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa assessed as infection inhibition rate at 10 ug/ml after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
25.0
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
Inhibition of Tobacco mosaic virus (TMV) infection in Nicotiana glutinosa after 3 to 4 days by half-leaf method
|
Tobacco mosaic virus
|
52.1
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 17
First Page : 4289
Last Page : 4295
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated right side of Nicotiana. tabacum L. leaves assessed as protection effect at 100 ug/mL preincubated 12 hr before viral challenge measured after 3 to 4 days
|
Tobacco mosaic virus
|
25.2
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
52.7
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect at 62.5 ug/ml co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
59.9
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect at 31.8 ug/ml co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
44.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect at 125 ug/ml co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
72.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect at 250 ug/ml co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
81.1
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as inactivation effect at 500 ug/ml co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
98.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as protective effect at 500 ug/ml treated 12 hr before viral inoculation measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
57.0
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus (TMV) infected left side of tobacco leaves assessed as curative effect at 500 ug/ml treated after viral inoculation measured at 3-4 days after viral challenge
|
Tobacco mosaic virus
|
54.8
%
|
|
Journal : J Agric Food Chem
Year : 2008
Volume : 56
Issue : 21
First Page : 10160
Last Page : 10167
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
|
Tobacco mosaic virus
|
117300.0
nM
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 3
First Page : 1572
Last Page : 1577
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 10 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
|
Tobacco mosaic virus
|
67.5
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 3
First Page : 1572
Last Page : 1577
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 5 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
|
Tobacco mosaic virus
|
46.6
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 3
First Page : 1572
Last Page : 1577
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 2.5 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
|
Tobacco mosaic virus
|
37.9
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 3
First Page : 1572
Last Page : 1577
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 1.25 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
|
Tobacco mosaic virus
|
28.0
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 3
First Page : 1572
Last Page : 1577
In vivo antiviral activity against Tobacco mosaic virus strain U1 (TMV) infected left side of Nicotiana glutinosa leaves assessed as decrease in local lesion numbers at 20 uM co-incubated with virus for 30 min before inoculation onto leaves measured at 3-4 days after viral challenge by half-leaf method
|
Tobacco mosaic virus
|
25.3
%
|
|
Journal : J Agric Food Chem
Year : 2010
Volume : 58
Issue : 3
First Page : 1572
Last Page : 1577
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated right side of Nicotiana. tabacum L. leaves assessed as protection effect at 500 ug/mL preincubated 12 hr before viral challenge measured after 3 to 4 days
|
Tobacco mosaic virus
|
66.6
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
In vivo antiviral activity against Tobacco mosaic virus (TMV) pre-inoculated Nicotiana. tabacum L. leaves assessed as curative effect at 100 ug/mL measured after 3 to 4 days
|
Tobacco mosaic virus
|
18.9
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
In vivo antiviral activity against Tobacco mosaic virus (TMV) pre-inoculated Nicotiana. tabacum L. leaves assessed as curative effect at 500 ug/mL measured after 3 to 4 days
|
Tobacco mosaic virus
|
56.0
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated left side of Nicotiana. tabacum L. leaves assessed as inactivation effect at 100 ug/mL co-incubated with virus measured after 3 to 4 days
|
Tobacco mosaic virus
|
37.7
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated left side of Nicotiana. tabacum L. leaves assessed as inactivation effect at 500 ug/mL co-incubated with virus measured after 3 to 4 days
|
Tobacco mosaic virus
|
68.5
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
Antiviral activity against Tobacco mosaic virus (TMV) inoculated in 5-6 growth stage leaf assessed as inhibition effect at 100 ug/mL at 25 degC after 72 hr by half-leaf method
|
Tobacco mosaic virus
|
23.9
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
Antiviral activity against Tobacco mosaic virus (TMV) inoculated in 5-6 growth stage leaf assessed as inhibition effect at 500 ug/mL at 25 degC after 72 hr by half-leaf method
|
Tobacco mosaic virus
|
70.2
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines.
Year : 2012
Volume : 60
Issue : 23
First Page : 5825
Last Page : 5831
Authors : Wang Z, Wang L, Ma S, Liu Y, Wang L, Wang Q.
Abstract : Based on our previous structure-activity relationship and antiviral mechanism studies, a series of 14-aminophenanthroindolizidines (1a-i, 2, and 3) were designed, targeting tobacco mosaic virus (TMV) RNA, and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 1d and 1h displayed significantly higher activity than commercial ningnanmycin, and thus emerged as potential inhibitors of plant virus. The introduction of amino groups at the 14-position of phenanthroindolizidines, which is proposed to interact with arginine residues around the TMV RNA, increased anti-TMV activity.
Antiviral activity against Tobacco mosaic virus (TMV) in compound treated Nicotiana tabacum L.leaves assessed as curative effect
|
Tobacco mosaic virus
|
227.0
ug.mL-1
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 4
First Page : 1383
Last Page : 1388
Antiviral activity against Tobacco mosaic virus (TMV) in compound treated Nicotiana tabacum L.leaves assessed as curative effect at 250 ug/ml
|
Tobacco mosaic virus
|
50.7
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 4
First Page : 1383
Last Page : 1388
Antiviral activity against Tobacco mosaic virus (TMV) in compound treated Nicotiana tabacum L.leaves assessed as curative effect at 125 ug/ml
|
Tobacco mosaic virus
|
41.9
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 4
First Page : 1383
Last Page : 1388
Antiviral activity against Tobacco mosaic virus (TMV) in compound treated Nicotiana tabacum L.leaves assessed as curative effect at 500 ug/ml
|
Tobacco mosaic virus
|
56.2
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 4
First Page : 1383
Last Page : 1388
Antiviral activity against Tobacco mosaic virus (TMV) in compound treated Nicotiana tabacum L.leaves assessed as curative effect from local lesions at 500 ug/ml measured after 3 to 4 days
|
Tobacco mosaic virus
|
56.2
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 4
First Page : 1383
Last Page : 1388
Antiviral activity against Tobacco mosaic virus (TMV) in compound treated Nicotiana tabacum L.leaves assessed as protective effect from local lesions at 500 ug/ml measured after 3 to 4 days
|
Tobacco mosaic virus
|
60.6
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 4
First Page : 1383
Last Page : 1388
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated right side of Nicotiana tabacum L. leaves assessed as protection effect at 100 ug/mL preincubated 12 hr before viral challenge measured after 3 to 4 days
|
Tobacco mosaic virus
|
25.2
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated right side of Nicotiana tabacum L. leaves assessed as protection effect at 500 ug/mL preincubated 12 hr before viral challenge measured after 3 to 4 days
|
Tobacco mosaic virus
|
66.6
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
In vivo antiviral activity against Tobacco mosaic virus (TMV) pre-inoculated Nicotiana tabacum L. leaves assessed as curative effect at 100 ug/mL measured after 3 to 4 days
|
Tobacco mosaic virus
|
18.9
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
In vivo antiviral activity against Tobacco mosaic virus (TMV) pre-inoculated Nicotiana tabacum L. leaves assessed as curative effect at 500 ug/mL measured after 3 to 4 days
|
Tobacco mosaic virus
|
56.0
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated left side of Nicotiana tabacum L. leaves assessed as inactivation effect at 100 ug/mL co-incubated with virus measured after 3 to 4 days
|
Tobacco mosaic virus
|
37.7
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
In vivo antiviral activity against Tobacco mosaic virus (TMV) inoculated left side of Nicotiana tabacum L. leaves assessed as inactivation effect at 500 ug/mL co-incubated with virus measured after 3 to 4 days
|
Tobacco mosaic virus
|
68.5
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
Antiviral activity against Tobacco mosaic virus (TMV) inoculated in 5-6 growth stage leaf assessed as inhibition effect at 100 ug/mL at 25 degC after 72 hr by half-leaf method
|
Tobacco mosaic virus
|
30.4
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
Antiviral activity against Tobacco mosaic virus (TMV) inoculated in 5-6 growth stage leaf assessed as inhibition effect at 500 ug/mL at 25 degC after 72 hr by half-leaf method
|
Tobacco mosaic virus
|
71.4
%
|
|
Journal : J Agric Food Chem
Title : Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues.
Year : 2012
Volume : 60
Issue : 41
First Page : 10212
Last Page : 10219
Authors : Wang Z, Wei P, Wang L, Wang Q.
Abstract : On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent). Especially, (S)-deoxytylophorinine (5) with excellent anti-TMV activity (inactivation activity, 59.8%/500 μg mL(-1) and 40.3%/100 μg mL(-1); curative activity, 65.1%/500 μg mL(-1) and 43.7%/100 μg mL(-1); and protection activity, 70.2%/500 μg mL(-1) and 51.3%/100 μg mL(-1)) emerged as a potential inhibitor of the plant virus. Compound 20 exhibited a strong in vivo protection effect against TMV at 100 μg mL(-1), which indicated that phenanthroindolizidine analogues with a seven-membered D ring have a new and interesting structural scaffold and have great potential for further development as tobacco protection agents.
Antiviral activity against Tobacco mosaic virus (TMV) inoculated in whole leaves of Nicotiana tabacum L. assessed as curative effect measured as local lesion number at 500 mg/l after 3 to 4 days
|
Tobacco mosaic virus
|
28.9
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and antiviral activity of novel chiral cyanoacrylate derivatives.
Year : 2005
Volume : 53
Issue : 20
First Page : 7886
Last Page : 7891
Authors : Song B, Zhang H, Wang H, Yang S, Jin L, Hu D, Pang L, Xue W.
Abstract : 2-Cyanoacrylate is an important kind of herbicide targeted in photosystem II. Starting from cyano ethyl acetate, the chiral title compounds were synthesized under microwave irradiation, which has the advantages of shorter reaction time, higher yield, and simpler procedure. A half-leaf method was used to determine the inhibition and curative efficacies of the eight chiral products against tobacco mosaic virus in vivo. It was found that chiral compound IIc-R possesses moderate inhibition and curative effect in vivo with rates of 89.1 and 43.1%, respectively. In the MTT test, these new chiral compounds were found to possess weak antiproliferation activities to PC3 and A431 cells.
Antiviral activity against Tobacco mosaic virus (TMV) inoculated in left side of Nicotiana tabacum L. leaves assessed as inhibition of local lesion number at 500 mg/l measured after 3 to 4 days
|
Tobacco mosaic virus
|
88.9
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and antiviral activity of novel chiral cyanoacrylate derivatives.
Year : 2005
Volume : 53
Issue : 20
First Page : 7886
Last Page : 7891
Authors : Song B, Zhang H, Wang H, Yang S, Jin L, Hu D, Pang L, Xue W.
Abstract : 2-Cyanoacrylate is an important kind of herbicide targeted in photosystem II. Starting from cyano ethyl acetate, the chiral title compounds were synthesized under microwave irradiation, which has the advantages of shorter reaction time, higher yield, and simpler procedure. A half-leaf method was used to determine the inhibition and curative efficacies of the eight chiral products against tobacco mosaic virus in vivo. It was found that chiral compound IIc-R possesses moderate inhibition and curative effect in vivo with rates of 89.1 and 43.1%, respectively. In the MTT test, these new chiral compounds were found to possess weak antiproliferation activities to PC3 and A431 cells.
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco plant leaf assessed as curative effect at 100 ug/ml after 3 to 4 days
|
Tobacco mosaic virus
|
23.1
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco plant leaf assessed as curative effect at 500 ug/ml after 3 to 4 days
|
Tobacco mosaic virus
|
58.7
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco plant leaf assessed as inactivation effect at 100 ug/ml after 3 to 4 days
|
Tobacco mosaic virus
|
25.0
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco plant leaf assessed as inactivation effect at 500 ug/ml after 3 to 4 days
|
Tobacco mosaic virus
|
54.2
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco plant leaf assessed as protection effect at 500 ug/ml after 3 to 4 days
|
Tobacco mosaic virus
|
57.9
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco plant leaf assessed as protection effect at 100 ug/ml after 3 to 4 days
|
Tobacco mosaic virus
|
38.4
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco leaf juice at 100 ug/ml after 72 hr by half-leaf method
|
Tobacco mosaic virus
|
26.8
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035
Antiviral activity against Tobacco mosaic virus (TMV) in tobacco leaf juice at 500 ug/ml after 72 hr by half-leaf method
|
Tobacco mosaic virus
|
69.3
%
|
|
Journal : J Agric Food Chem
Year : 2013
Volume : 61
Issue : 5
First Page : 1030
Last Page : 1035