|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation measured after 36 days by leaf-dipping method
|
Mythimna separata
|
40.7
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 17
First Page : 7919
Last Page : 7923
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation measured after 24 days by leaf-dipping method
|
Mythimna separata
|
35.7
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 17
First Page : 7919
Last Page : 7923
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation measured after 12 days by leaf-dipping method
|
Mythimna separata
|
21.4
%
|
|
Journal : J Agric Food Chem
Year : 2009
Volume : 57
Issue : 17
First Page : 7919
Last Page : 7923
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in wheat leaves at 1 mg/mL after 33 days by leaf-dipping method
|
Mythimna separata
|
44.8
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and quantitative structure-activity relationship (QSAR) study of novel isoxazoline and oxime derivatives of podophyllotoxin as insecticidal agents.
Year : 2012
Volume : 60
Issue : 34
First Page : 8435
Last Page : 8443
Authors : Wang Y, Shao Y, Wang Y, Fan L, Yu X, Zhi X, Yang C, Qu H, Yao X, Xu H.
Abstract : In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, 33 isoxazoline and oxime derivatives of podophyllotoxin modified in the C and D rings were synthesized and their structures were characterized by Proton nuclear magnetic resonance ((1)H NMR), high-resolution mass spectrometry (HRMS), electrospray ionization-mass spectrometry (ESI-MS), optical rotation, melting point (mp), and infrared (IR) spectroscopy. The stereochemical configurations of compounds 5e, 5f, and 9f were unambiguously determined by X-ray crystallography. Their insecticidal activity was evaluated against the pre-third-instar larvae of northern armyworm, Mythimna separata (Walker), in vivo. Compounds 5e, 9c, 11g, and 11h especially exhibited more promising insecticidal activity than toosendanin, a commercial botanical insecticide extracted from Melia azedarach . A genetic algorithm combined with multiple linear regression (GA-MLR) calculation is performed by the MOBY DIGS package. Five selected descriptors are as follows: one two-dimensional (2D) autocorrelation descriptor (GATS4e), one edge adjacency indice (EEig06x), one RDF descriptor (RDF080v), one three-dimensional (3D) MoRSE descriptor (Mor09v), and one atom-centered fragment (H-052) descriptor. Quantitative structure-activity relationship studies demonstrated that the insecticidal activity of these compounds was mainly influenced by many factors, such as electronic distribution, steric factors, etc. For this model, the standard deviation error in prediction (SDEP) is 0.0592, the correlation coefficient (R(2)) is 0.861, and the leave-one-out cross-validation correlation coefficient (Q(2)loo) is 0.797.
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in wheat leaves at 1 mg/mL after 20 days by leaf-dipping method
|
Mythimna separata
|
13.8
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and quantitative structure-activity relationship (QSAR) study of novel isoxazoline and oxime derivatives of podophyllotoxin as insecticidal agents.
Year : 2012
Volume : 60
Issue : 34
First Page : 8435
Last Page : 8443
Authors : Wang Y, Shao Y, Wang Y, Fan L, Yu X, Zhi X, Yang C, Qu H, Yao X, Xu H.
Abstract : In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, 33 isoxazoline and oxime derivatives of podophyllotoxin modified in the C and D rings were synthesized and their structures were characterized by Proton nuclear magnetic resonance ((1)H NMR), high-resolution mass spectrometry (HRMS), electrospray ionization-mass spectrometry (ESI-MS), optical rotation, melting point (mp), and infrared (IR) spectroscopy. The stereochemical configurations of compounds 5e, 5f, and 9f were unambiguously determined by X-ray crystallography. Their insecticidal activity was evaluated against the pre-third-instar larvae of northern armyworm, Mythimna separata (Walker), in vivo. Compounds 5e, 9c, 11g, and 11h especially exhibited more promising insecticidal activity than toosendanin, a commercial botanical insecticide extracted from Melia azedarach . A genetic algorithm combined with multiple linear regression (GA-MLR) calculation is performed by the MOBY DIGS package. Five selected descriptors are as follows: one two-dimensional (2D) autocorrelation descriptor (GATS4e), one edge adjacency indice (EEig06x), one RDF descriptor (RDF080v), one three-dimensional (3D) MoRSE descriptor (Mor09v), and one atom-centered fragment (H-052) descriptor. Quantitative structure-activity relationship studies demonstrated that the insecticidal activity of these compounds was mainly influenced by many factors, such as electronic distribution, steric factors, etc. For this model, the standard deviation error in prediction (SDEP) is 0.0592, the correlation coefficient (R(2)) is 0.861, and the leave-one-out cross-validation correlation coefficient (Q(2)loo) is 0.797.
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in wheat leaves at 1 mg/mL after 5 days by leaf-dipping method
|
Mythimna separata
|
6.7
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and quantitative structure-activity relationship (QSAR) study of novel isoxazoline and oxime derivatives of podophyllotoxin as insecticidal agents.
Year : 2012
Volume : 60
Issue : 34
First Page : 8435
Last Page : 8443
Authors : Wang Y, Shao Y, Wang Y, Fan L, Yu X, Zhi X, Yang C, Qu H, Yao X, Xu H.
Abstract : In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, 33 isoxazoline and oxime derivatives of podophyllotoxin modified in the C and D rings were synthesized and their structures were characterized by Proton nuclear magnetic resonance ((1)H NMR), high-resolution mass spectrometry (HRMS), electrospray ionization-mass spectrometry (ESI-MS), optical rotation, melting point (mp), and infrared (IR) spectroscopy. The stereochemical configurations of compounds 5e, 5f, and 9f were unambiguously determined by X-ray crystallography. Their insecticidal activity was evaluated against the pre-third-instar larvae of northern armyworm, Mythimna separata (Walker), in vivo. Compounds 5e, 9c, 11g, and 11h especially exhibited more promising insecticidal activity than toosendanin, a commercial botanical insecticide extracted from Melia azedarach . A genetic algorithm combined with multiple linear regression (GA-MLR) calculation is performed by the MOBY DIGS package. Five selected descriptors are as follows: one two-dimensional (2D) autocorrelation descriptor (GATS4e), one edge adjacency indice (EEig06x), one RDF descriptor (RDF080v), one three-dimensional (3D) MoRSE descriptor (Mor09v), and one atom-centered fragment (H-052) descriptor. Quantitative structure-activity relationship studies demonstrated that the insecticidal activity of these compounds was mainly influenced by many factors, such as electronic distribution, steric factors, etc. For this model, the standard deviation error in prediction (SDEP) is 0.0592, the correlation coefficient (R(2)) is 0.861, and the leave-one-out cross-validation correlation coefficient (Q(2)loo) is 0.797.
|
Toxicity in Artemia salina (brine shrimp) at 28 degC after 48 hr
|
Artemia salina
|
1.0
ug.mL-1
|
|
Journal : J Agric Food Chem
Title : Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
Year : 2012
Volume : 60
Issue : 13
First Page : 3424
Last Page : 3431
Authors : Li XJ, Zhang Q, Zhang AL, Gao JM.
Abstract : Thirty-nine fungal metabolites 1-39, including two new alkaloids, 12β-hydroxy-13α-methoxyverruculogen TR-2 (6) and 3-hydroxyfumiquinazoline A (16), were isolated from the fermentation broth of Aspergillus fumigatus LN-4, an endophytic fungus isolated from the stem bark of Melia azedarach. Their structures were elucidated on the basis of detailed spectroscopic analysis (mass spectrometry and one- and two-dimensional NMR experiments) and by comparison of their NMR data with those reported in the literature. These isolated compounds were evaluated for in vitro antifungal activities against some phytopathogenic fungi, toxicity against brine shrimps, and antifeedant activities against armyworm larvae (Mythimna separata Walker). Among them, sixteen compounds showed potent antifungal activities against phytopathogenic fungi (Botrytis cinerea, Alternaria solani, Alternaria alternata, Colletotrichum gloeosporioides, Fusarium solani, Fusarium oxysporum f. sp. niveum, Fusarium oxysporum f. sp. vasinfectum, and Gibberella saubinettii), and four of them, 12β-hydroxy-13α-methoxyverruculogen TR-2 (6), fumitremorgin B (7), verruculogen (8), and helvolic acid (39), exhibited antifungal activities with MIC values of 6.25-50 μg/mL, which were comparable to the two positive controls carbendazim and hymexazol. In addition, of eighteen that exerted moderate lethality toward brine shrimps, compounds 7 and 8 both showed significant toxicities with median lethal concentration (LC(50)) values of 13.6 and 15.8 μg/mL, respectively. Furthermore, among nine metabolites that were found to possess antifeedant activity against armyworm larvae, compounds 7 and 8 gave the best activity with antifeedant indexes (AFI) of 50.0% and 55.0%, respectively. Structure-activity relationships of the metabolites were also discussed.
|
Antifeedant activity against Mythimna separata (Oriental armyworm) larvae assessed as antifeedant index by area of the leaf consumed
|
Mythimna separata
|
97.5
%
|
|
Journal : J Agric Food Chem
Title : Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
Year : 2012
Volume : 60
Issue : 13
First Page : 3424
Last Page : 3431
Authors : Li XJ, Zhang Q, Zhang AL, Gao JM.
Abstract : Thirty-nine fungal metabolites 1-39, including two new alkaloids, 12β-hydroxy-13α-methoxyverruculogen TR-2 (6) and 3-hydroxyfumiquinazoline A (16), were isolated from the fermentation broth of Aspergillus fumigatus LN-4, an endophytic fungus isolated from the stem bark of Melia azedarach. Their structures were elucidated on the basis of detailed spectroscopic analysis (mass spectrometry and one- and two-dimensional NMR experiments) and by comparison of their NMR data with those reported in the literature. These isolated compounds were evaluated for in vitro antifungal activities against some phytopathogenic fungi, toxicity against brine shrimps, and antifeedant activities against armyworm larvae (Mythimna separata Walker). Among them, sixteen compounds showed potent antifungal activities against phytopathogenic fungi (Botrytis cinerea, Alternaria solani, Alternaria alternata, Colletotrichum gloeosporioides, Fusarium solani, Fusarium oxysporum f. sp. niveum, Fusarium oxysporum f. sp. vasinfectum, and Gibberella saubinettii), and four of them, 12β-hydroxy-13α-methoxyverruculogen TR-2 (6), fumitremorgin B (7), verruculogen (8), and helvolic acid (39), exhibited antifungal activities with MIC values of 6.25-50 μg/mL, which were comparable to the two positive controls carbendazim and hymexazol. In addition, of eighteen that exerted moderate lethality toward brine shrimps, compounds 7 and 8 both showed significant toxicities with median lethal concentration (LC(50)) values of 13.6 and 15.8 μg/mL, respectively. Furthermore, among nine metabolites that were found to possess antifeedant activity against armyworm larvae, compounds 7 and 8 gave the best activity with antifeedant indexes (AFI) of 50.0% and 55.0%, respectively. Structure-activity relationships of the metabolites were also discussed.
|
Feeding deterrent activity against Tribolium castaneum (red flour beetle) adults using wheat flour assessed as inhibition of insect feeding measured after 3 days
|
Tribolium castaneum
|
94.3
ppm
|
|
Journal : J Agric Food Chem
Year : 2011
Volume : 59
Issue : 8
First Page : 3701
Last Page : 3706
|
Insecticidal activity against Mythimna separata (Oriental armyworm) in wheat leaves assessed as mortality rate at 1 mg/mL at 25 degC measured after 35 days by leaf-dipping method relative to control
|
Mythimna separata
|
48.1
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 28
First Page : 7016
Last Page : 7021
|
Insecticidal activity against Mythimna separata (Oriental armyworm) in wheat leaves assessed as mortality rate at 1 mg/mL at 25 degC measured after 25 days by leaf-dipping method relative to control
|
Mythimna separata
|
33.3
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 28
First Page : 7016
Last Page : 7021
|
Insecticidal activity against Mythimna separata (Oriental armyworm) in wheat leaves assessed as mortality rate at 1 mg/mL at 25 degC measured after 10 days by leaf-dipping method relative to control
|
Mythimna separata
|
27.6
%
|
|
Journal : J Agric Food Chem
Year : 2012
Volume : 60
Issue : 28
First Page : 7016
Last Page : 7021
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 30 days by leaf-dipping method
|
Mythimna separata
|
46.4
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Year : 2010
Volume : 20
Issue : 8
First Page : 2500
Last Page : 2502
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 20 days by leaf-dipping method
|
Mythimna separata
|
34.5
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Year : 2010
Volume : 20
Issue : 8
First Page : 2500
Last Page : 2502
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 10 days by leaf-dipping method
|
Mythimna separata
|
30.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Year : 2010
Volume : 20
Issue : 8
First Page : 2500
Last Page : 2502
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 33 days by leaf-dipping method
|
Mythimna separata
|
50.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo.
Year : 2010
Volume : 20
Issue : 15
First Page : 4503
Last Page : 4506
Authors : Xu H, He XQ.
Abstract : To discover the more potent analogs, 12 novel monomethyl phthalate derivatives of podophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1mg/mL. Compounds 8e-i showed the higher insecticidal activity than podophyllotoxin. Especially 8g exhibited the most potent insecticidal activity compared with toosendanin, a commercially available insecticide derived from Melia azedarach. The structure-activity relationships demonstrated that trans-lactone, 4beta-substitution, 2beta-chlorine substitution, and 4'-methoxy group were the important structural properties of podophyllotoxins for good insecticidal activity.
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 20 days by leaf-dipping method
|
Mythimna separata
|
31.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo.
Year : 2010
Volume : 20
Issue : 15
First Page : 4503
Last Page : 4506
Authors : Xu H, He XQ.
Abstract : To discover the more potent analogs, 12 novel monomethyl phthalate derivatives of podophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1mg/mL. Compounds 8e-i showed the higher insecticidal activity than podophyllotoxin. Especially 8g exhibited the most potent insecticidal activity compared with toosendanin, a commercially available insecticide derived from Melia azedarach. The structure-activity relationships demonstrated that trans-lactone, 4beta-substitution, 2beta-chlorine substitution, and 4'-methoxy group were the important structural properties of podophyllotoxins for good insecticidal activity.
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 10 days by leaf-dipping method
|
Mythimna separata
|
30.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo.
Year : 2010
Volume : 20
Issue : 15
First Page : 4503
Last Page : 4506
Authors : Xu H, He XQ.
Abstract : To discover the more potent analogs, 12 novel monomethyl phthalate derivatives of podophyllotoxin were synthesized and preliminarily tested against the pre-third-instar larvae of Mythimna separata Walker in vivo at the concentration of 1mg/mL. Compounds 8e-i showed the higher insecticidal activity than podophyllotoxin. Especially 8g exhibited the most potent insecticidal activity compared with toosendanin, a commercially available insecticide derived from Melia azedarach. The structure-activity relationships demonstrated that trans-lactone, 4beta-substitution, 2beta-chlorine substitution, and 4'-methoxy group were the important structural properties of podophyllotoxins for good insecticidal activity.
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 35 days by leaf-dipping method
|
Mythimna separata
|
48.0
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo.
Year : 2011
Volume : 21
Issue : 18
First Page : 5177
Last Page : 5180
Authors : Xu H, Zhang JL.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, 14 novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives were stereoselectively semisynthesized from podophyllotoxin, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Especially compounds 9c' and 9g' exhibited the most promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach at 1mg/mL. Generally, it was preliminarily demonstrated that arylsulfonyloxy groups at the C-2 position of benzyloxy moiety and the length of the side chain on the benzenesulfonyloxy group of 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxins might be important for the insecticidal activity.
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 20 days by leaf-dipping method
|
Mythimna separata
|
34.6
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo.
Year : 2011
Volume : 21
Issue : 18
First Page : 5177
Last Page : 5180
Authors : Xu H, Zhang JL.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, 14 novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives were stereoselectively semisynthesized from podophyllotoxin, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Especially compounds 9c' and 9g' exhibited the most promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach at 1mg/mL. Generally, it was preliminarily demonstrated that arylsulfonyloxy groups at the C-2 position of benzyloxy moiety and the length of the side chain on the benzenesulfonyloxy group of 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxins might be important for the insecticidal activity.
|
In vivo insecticidal activity against pre-third-instar larval stage of Mythimna separata (Oriental armyworm) in corn leaves assessed as corrected mortality rate at 1 mg/ml treated for 3 secs before larval infestation on corn leaves measured after 10 days by leaf-dipping method
|
Mythimna separata
|
17.9
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Title : Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo.
Year : 2011
Volume : 21
Issue : 18
First Page : 5177
Last Page : 5180
Authors : Xu H, Zhang JL.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, 14 novel 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxin derivatives were stereoselectively semisynthesized from podophyllotoxin, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Especially compounds 9c' and 9g' exhibited the most promising and pronounced insecticidal activity than toosendanin, a commercial insecticide derived from Melia azedarach at 1mg/mL. Generally, it was preliminarily demonstrated that arylsulfonyloxy groups at the C-2 position of benzyloxy moiety and the length of the side chain on the benzenesulfonyloxy group of 4α-arylsulfonyloxybenzyloxy-2β-chloropodophyllotoxins might be important for the insecticidal activity.
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in compound treated fresh corn leaves assessed as corrected mortality at 1 mg/ml measured after 35 days by leaf-dipping method
|
Mythimna separata
|
53.8
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Year : 2012
Volume : 22
Issue : 17
First Page : 5384
Last Page : 5387
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in compound treated fresh corn leaves assessed as corrected mortality at 1 mg/ml measured after 20 days by leaf-dipping method
|
Mythimna separata
|
33.3
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Year : 2012
Volume : 22
Issue : 17
First Page : 5384
Last Page : 5387
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) in compound treated fresh corn leaves assessed as corrected mortality at 1 mg/ml measured after 10 days by leaf-dipping method
|
Mythimna separata
|
24.1
%
|
|
Journal : Bioorg. Med. Chem. Lett.
Year : 2012
Volume : 22
Issue : 17
First Page : 5384
Last Page : 5387
|
Insecticidal activity against Mythimna separata (Oriental armyworm) pre-third-instar larvae fed on 1 mg/ml compound pre-treated wheat leaves assessed as insect mortality by leaf-dipping method
|
Mythimna separata
|
None
|
|
Journal : Ind Crops Prod
Title : Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna separata Walker in vivo
Year : 2013
Volume : 42
First Page : 520
Last Page : 526
Authors : Zhi Xy, Chun Yang, Hui Xu, Rui Zhang, Ya-zhen Ke, Ying Hu.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, a series of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring were synthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Among all the derivatives, compounds 7b, 7g, 7h and 7j exhibited more pronounced insecticidal activity than or comparable to toosendanin. Especially compounds 7h and 7j displayed the best promising insecticidal activity. Meanwhile, the relationships between their structures and the insecticidal activity were also described.
|
Insecticidal activity against Mythimna separata (Oriental armyworm) pre-third-instar larvae fed on 1 mg/ml compound pre-treated wheat leaves assessed as insect mortality measured after 34 days by leaf-dipping method
|
Mythimna separata
|
51.7
%
|
|
Journal : Ind Crops Prod
Title : Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna separata Walker in vivo
Year : 2013
Volume : 42
First Page : 520
Last Page : 526
Authors : Zhi Xy, Chun Yang, Hui Xu, Rui Zhang, Ya-zhen Ke, Ying Hu.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, a series of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring were synthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Among all the derivatives, compounds 7b, 7g, 7h and 7j exhibited more pronounced insecticidal activity than or comparable to toosendanin. Especially compounds 7h and 7j displayed the best promising insecticidal activity. Meanwhile, the relationships between their structures and the insecticidal activity were also described.
|
Insecticidal activity against Mythimna separata (Oriental armyworm) pre-third-instar larvae fed on 1 mg/ml compound pre-treated wheat leaves assessed as insect mortality measured after 20 days by leaf-dipping method
|
Mythimna separata
|
27.6
%
|
|
Journal : Ind Crops Prod
Title : Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna separata Walker in vivo
Year : 2013
Volume : 42
First Page : 520
Last Page : 526
Authors : Zhi Xy, Chun Yang, Hui Xu, Rui Zhang, Ya-zhen Ke, Ying Hu.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, a series of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring were synthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Among all the derivatives, compounds 7b, 7g, 7h and 7j exhibited more pronounced insecticidal activity than or comparable to toosendanin. Especially compounds 7h and 7j displayed the best promising insecticidal activity. Meanwhile, the relationships between their structures and the insecticidal activity were also described.
|
Insecticidal activity against Mythimna separata (Oriental armyworm) pre-third-instar larvae fed on 1 mg/ml compound pre-treated wheat leaves assessed as insect mortality measured after 10 days by leaf-dipping method
|
Mythimna separata
|
10.0
%
|
|
Journal : Ind Crops Prod
Title : Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna separata Walker in vivo
Year : 2013
Volume : 42
First Page : 520
Last Page : 526
Authors : Zhi Xy, Chun Yang, Hui Xu, Rui Zhang, Ya-zhen Ke, Ying Hu.
Abstract : In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, a series of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring were synthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Among all the derivatives, compounds 7b, 7g, 7h and 7j exhibited more pronounced insecticidal activity than or comparable to toosendanin. Especially compounds 7h and 7j displayed the best promising insecticidal activity. Meanwhile, the relationships between their structures and the insecticidal activity were also described.
|
Insecticidal activity against Spodoptera litura third-instar larvae fed on compound pre-treated Ricinus communis L. leaves assessed as insect mortality at 1 mg/ml measured 12 days after compound treatment
|
Spodoptera litura
|
100.0
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Antifeedant activity against Spodoptera litura third-instar larvae fed on compound pre-treated castor-oil plant leaves assessed as antifeedant rate at 1 mg/ml after 48 hr
|
Spodoptera litura
|
90.6
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Antifeedant activity against Spodoptera litura third-instar larvae fed on compound pre-treated castor-oil plant leaves assessed as antifeedant rate at 1 mg/ml after 24 hr
|
Spodoptera litura
|
87.1
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima fourth-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 72 hr after compound treatment
|
Brontispa longissima
|
73.33
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima fourth-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 48 hr after compound treatment
|
Brontispa longissima
|
66.67
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima fourth-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 24 hr after compound treatment
|
Brontispa longissima
|
60.0
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima fourth-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 12 hr after compound treatment
|
Brontispa longissima
|
53.33
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima third-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 72 hr after compound treatment
|
Brontispa longissima
|
83.33
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima third-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 48 hr after compound treatment
|
Brontispa longissima
|
73.33
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima third-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 24 hr after compound treatment
|
Brontispa longissima
|
63.33
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima third-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 12 hr after compound treatment
|
Brontispa longissima
|
53.33
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima second-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 72 hr after compound treatment
|
Brontispa longissima
|
100.0
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima second-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 48 hr after compound treatment
|
Brontispa longissima
|
100.0
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima second-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 24 hr after compound treatment
|
Brontispa longissima
|
100.0
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Brontispa longissima second-instar larvae fed on compound pre-treated Cocos nucifera L. leaves assessed as insect mortality at 50 ug/ml measured 12 hr after compound treatment
|
Brontispa longissima
|
96.67
%
|
|
Journal : J Pesticide Sci
Year : 2011
Volume : 36
Issue : 1
First Page : 22
Last Page : 26
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean emergence at 25 ug/ml in artificial diet (Rvb = 83.3 %)
|
Spodoptera frugiperda
|
4.17
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean emergence at 52 ug/ml in artificial diet (Rvb = 83.3 %)
|
Spodoptera frugiperda
|
0.0
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean pupation at 25 ug/ml in artificial diet (Rvb = 87.5 %)
|
Spodoptera frugiperda
|
4.17
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean pupation at 52 ug/ml in artificial diet (Rvb = 87.5 %)
|
Spodoptera frugiperda
|
4.17
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean emergence days at 5 ug/ml in artificial diet (Rvb = 33 days)
|
Spodoptera frugiperda
|
36.0
day
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean emergence days at 25 ug/ml in artificial diet (Rvb = 33 days)
|
Spodoptera frugiperda
|
36.0
day
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean emergence at 5 ug/ml in artificial diet (Rvb = 83.3 %)
|
Spodoptera frugiperda
|
16.7
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean time to pupation at 5 ug/ml in artificial diet (Rvb = 22 days)
|
Spodoptera frugiperda
|
23.5
day
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean time to pupation at 25 ug/ml in artificial diet (Rvb = 22 days)
|
Spodoptera frugiperda
|
24.0
day
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean time to pupation at 52 ug/ml in artificial diet (Rvb = 22 days)
|
Spodoptera frugiperda
|
24.0
day
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Antifeedant activity against adult of Tribolium castaneum (red flour beetle) after 3 days
|
Tribolium castaneum
|
66.0
ppm
|
|
Journal : J Agric Food Chem
Year : 2002
Volume : 50
Issue : 6
First Page : 1447
Last Page : 1450
|
Antifeedant activity against larvae of Tribolium castaneum (red flour beetle) after 3 days
|
Tribolium castaneum
|
48.0
ppm
|
|
Journal : J Agric Food Chem
Year : 2002
Volume : 50
Issue : 6
First Page : 1447
Last Page : 1450
|
Antifeedant activity against adult of Sitophilus zeamais after 3 days
|
Sitophilus zeamais
|
100.0
ppm
|
|
Journal : J Agric Food Chem
Year : 2002
Volume : 50
Issue : 6
First Page : 1447
Last Page : 1450
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight of pupae at 5 ug/ml in artificial diet (Rvb = 281.5 +/- 10.3 mg)
|
Spodoptera frugiperda
|
95.0
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight of pupae at 25 ug/ml in artificial diet (Rvb = 281.5 +/- 10.3 mg)
|
Spodoptera frugiperda
|
45.1
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight of pupae at 52 ug/ml in artificial diet (Rvb = 281.5 +/- 10.3 mg)
|
Spodoptera frugiperda
|
38.0
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean pupation at 5 ug/ml in artificial diet (Rvb = 87.5 %)
|
Spodoptera frugiperda
|
17.9
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean length at 52 ug/ml in artificial diet measured after 7 days (Rvb = 28 +/- 4.1 mg)
|
Spodoptera frugiperda
|
2.8
mm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean length at 5 ug/ml in artificial diet measured after 7 days (Rvb = 28 +/- 4.1 mg)
|
Spodoptera frugiperda
|
7.0
mm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean length at 25 ug/ml in artificial diet measured after 7 days (Rvb = 28 +/- 4.1 mg)
|
Spodoptera frugiperda
|
6.1
mm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight gain at 5 ug/ml in artificial diet measured after 7 days (Rvb = 469.5 +/- 6.59 mg)
|
Spodoptera frugiperda
|
21.5
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight gain at 25 ug/ml in artificial diet measured after 7 days (Rvb = 469.5 +/- 6.59 mg)
|
Spodoptera frugiperda
|
17.0
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight gain at 52 ug/ml in artificial diet measured after 7 days (Rvb = 469.5 +/- 6.59 mg)
|
Spodoptera frugiperda
|
11.2
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mortality measured after 7 days
|
Spodoptera frugiperda
|
7.0
ppm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mortality at 52 ug/ml in artificial diet measured after 7 days (Rvb = 8.33%)
|
Spodoptera frugiperda
|
89.0
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mortality at 25 ug/ml in artificial diet measured after 7 days (Rvb = 8.33%)
|
Spodoptera frugiperda
|
70.0
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean length at 25 ug/ml in artificial diet measured after 7 days (Rvb = 0.95 +/- 0.2 cm)
|
Spodoptera frugiperda
|
0.77
cm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean length at 5 ug/ml in artificial diet measured after 7 days (Rvb = 0.95 +/- 0.2 cm)
|
Spodoptera frugiperda
|
0.98
cm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight gain at 52 ug/ml in artificial diet measured after 7 days (Rvb = 75.5 +/- 8.24 mg)
|
Spodoptera frugiperda
|
1.0
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight gain at 25 ug/ml in artificial diet measured after 7 days (Rvb = 75.5 +/- 8.24 mg)
|
Spodoptera frugiperda
|
2.3
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean weight gain at 5 ug/ml in artificial diet measured after 7 days (Rvb = 75.5 +/- 8.24 mg)
|
Spodoptera frugiperda
|
5.1
mg
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mean length at 52 ug/ml in artificial diet measured after 7 days (Rvb = 0.95 +/- 0.2 cm)
|
Spodoptera frugiperda
|
0.57
cm
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Insecticidal activity against Spodoptera frugiperda (fall armyworm) assessed as mortality at 5 ug/ml in artificial diet measured after 7 days (Rvb = 8.33%)
|
Spodoptera frugiperda
|
40.0
%
|
|
Journal : J Agric Food Chem
Year : 2000
Volume : 48
Issue : 5
First Page : 1903
Last Page : 1908
|
Antifeedant activity against larvae of Spodoptera eridania in Cucurbita maxima leaves at 0.25 ug/cm2 after 24 hr by leaf disk choice test
|
Spodoptera eridania
|
45.8
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Spodoptera eridania in Cucurbita maxima leaves at 0.5 ug/cm2 after 24 hr by leaf disk choice test
|
Spodoptera eridania
|
58.7
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Spodoptera eridania in Cucurbita maxima leaves at 1 ug/cm2 after 24 hr by leaf disk choice test
|
Spodoptera eridania
|
65.1
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Spodoptera eridania in Cucurbita maxima leaves at 4 ug/cm2 after 24 hr by leaf disk choice test
|
Spodoptera eridania
|
71.8
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Spodoptera eridania in Cucurbita maxima leaves at 10 ug/cm2 after 24 hr by leaf disk choice test
|
Spodoptera eridania
|
79.3
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Spodoptera eridania in Cucurbita maxima leaves at 14 ug/cm2 after 24 hr by leaf disk choice test
|
Spodoptera eridania
|
87.8
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Epilachna paenulata in Cucurbita maxima leaves at 4 ug/cm2 after 24 hr by leaf disc choice test
|
Epilachna
|
54.8
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Epilachna paenulata in Cucurbita maxima leaves at 8 ug/cm2 after 24 hr by leaf disc choice test
|
Epilachna
|
78.2
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against larvae of Epilachna paenulata in Cucurbita maxima leaves at 10 ug/cm2 after 24 hr by leaf disc choice test
|
Epilachna
|
90.7
%
|
|
Journal : Biosci. Biotechnol. Biochem.
Year : 2002
Volume : 66
Issue : 8
First Page : 1731
Last Page : 1736
|
Antifeedant activity against third-instar larval stage of Epilachna paenulata infested cucurbita maxima leaves assessed as feeding reduction after 24 hr by leaf disk choice assay
|
Epilachna
|
3.69
microg/cm2
|
|
Journal : J Agric Food Chem
Year : 2003
Volume : 51
Issue : 2
First Page : 369
Last Page : 374
|
Antifeedant activity against Tribolium castaneum (red flour beetle) assessed as reduction of food consumption after 3 days by flour disk bioassay relative to control
|
Tribolium castaneum
|
66.0
ppm
|
|
Journal : Molecules
Year : 2011
Volume : 16
Issue : 7
First Page : 6060
Last Page : 6067
|
Antifeedant activity against third-instar Epilachna paenulata measured assessed per cm2 leaf disk
|
Epilachna
|
3.69
ug
|
|
Journal : Bioresour Technol
Title : Antifeedant activity of ethanolic extract from Flourensia oolepis and isolation of pinocembrin as its active principle compound.
Year : 2009
Volume : 100
Issue : 14
First Page : 3669
Last Page : 3673
Authors : Diaz Napal GN, Carpinella MC, Palacios SM.
Abstract : The ethanolic extract from Flourensia oolepis aerial parts showed strong antifeedant activity against the pest larvae, Epilachna paenulata, with an antifeedant index (AI%) of 99.1% at 100 microg/cm(2). Based on chromatographic fractionation of the extract, guided by bioassays on E. paenulata, the flavanone pinocembrin (1) was isolated as the most active principle. In a choice assay, compound 1 showed strong antifeedant activity against E. paenulata, Xanthogaleruca luteola and Spodoptera frugiperda with an AI% of 90, 94 and 91% (p<0.01) respectively, at 50 microg/cm(2). The dosages necessary for 50% feeding inhibition of the insects (ED(50)) were 7.98, 6.13 and 8.86 microg/cm(2), respectively. The feeding inhibitory activity of 1 against E. paenulata was compared with the activity of other structurally related flavonoids like naringenin, which was inactive up to 100 microg/cm(2), catechin which was nearly 6 times less active than 1, and quercetin which was equally active as 1. The effect of these on the feeding behavior of E. paenulata was also studied.
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) assessed as corrected mortality rate at 1 mg/ml measured after 35 days by the leaf-dipping method
|
Mythimna separata
|
50.0
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents.
Year : 2013
Volume : 61
Issue : 3
First Page : 618
Last Page : 625
Authors : He S, Shao Y, Fan L, Che Z, Xu H, Zhi X, Wang J, Yao X, Qu H.
Abstract : In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, we have synthesized three series of novel 4-acyloxy compounds derived from podophyllotoxin modified in the A and C rings, which is isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum hexandrum . Their insecticidal activity was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata in vivo. Compound 9g displayed the best promising insecticidal activity. It revealed that cleavage of the 6,7-methylenedioxy group of podophyllotoxin will lead to a less active compound and that the C-4 position of podophyllotoxin was the important modification location. A quantitative structure-activity relationship (QSAR) model was developed by genetic algorithm combined with multiple linear regression (GA-MLR). For this model, the squared correlation coefficient (R(2)) is 0.914, the leave-one-out cross-validation correlation coefficient (Q(2)(LOO)) is 0.881, and the root-mean-square error (RMSE) is 0.024. Five descriptors, BEHm2, Mor14v, Wap, G1v, and RDF020e, are likely to influence the biological activity of these compounds. Among them, two important ones are BEHm2 and Mor14v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents.
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) assessed as corrected mortality rate at 1 mg/ml measured after 20 days by the leaf-dipping method
|
Mythimna separata
|
20.0
%
|
|
Journal : J Agric Food Chem
Title : Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents.
Year : 2013
Volume : 61
Issue : 3
First Page : 618
Last Page : 625
Authors : He S, Shao Y, Fan L, Che Z, Xu H, Zhi X, Wang J, Yao X, Qu H.
Abstract : In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, we have synthesized three series of novel 4-acyloxy compounds derived from podophyllotoxin modified in the A and C rings, which is isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum hexandrum . Their insecticidal activity was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata in vivo. Compound 9g displayed the best promising insecticidal activity. It revealed that cleavage of the 6,7-methylenedioxy group of podophyllotoxin will lead to a less active compound and that the C-4 position of podophyllotoxin was the important modification location. A quantitative structure-activity relationship (QSAR) model was developed by genetic algorithm combined with multiple linear regression (GA-MLR). For this model, the squared correlation coefficient (R(2)) is 0.914, the leave-one-out cross-validation correlation coefficient (Q(2)(LOO)) is 0.881, and the root-mean-square error (RMSE) is 0.024. Five descriptors, BEHm2, Mor14v, Wap, G1v, and RDF020e, are likely to influence the biological activity of these compounds. Among them, two important ones are BEHm2 and Mor14v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents.
|
Insecticidal activity against pre-third-instar larvae of Mythimna separata (Oriental armyworm) assessed as corrected mortality rate at 1 mg/ml measured after 10 days by the leaf-dipping method
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Mythimna separata
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10.0
%
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Journal : J Agric Food Chem
Title : Synthesis and quantitative structure-activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents.
Year : 2013
Volume : 61
Issue : 3
First Page : 618
Last Page : 625
Authors : He S, Shao Y, Fan L, Che Z, Xu H, Zhi X, Wang J, Yao X, Qu H.
Abstract : In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, we have synthesized three series of novel 4-acyloxy compounds derived from podophyllotoxin modified in the A and C rings, which is isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum hexandrum . Their insecticidal activity was preliminarily evaluated against the pre-third-instar larvae of Mythimna separata in vivo. Compound 9g displayed the best promising insecticidal activity. It revealed that cleavage of the 6,7-methylenedioxy group of podophyllotoxin will lead to a less active compound and that the C-4 position of podophyllotoxin was the important modification location. A quantitative structure-activity relationship (QSAR) model was developed by genetic algorithm combined with multiple linear regression (GA-MLR). For this model, the squared correlation coefficient (R(2)) is 0.914, the leave-one-out cross-validation correlation coefficient (Q(2)(LOO)) is 0.881, and the root-mean-square error (RMSE) is 0.024. Five descriptors, BEHm2, Mor14v, Wap, G1v, and RDF020e, are likely to influence the biological activity of these compounds. Among them, two important ones are BEHm2 and Mor14v. This study will pave the way for further design, structural modification, and development of podophyllotoxin derivatives as insecticidal agents.
